IMP: Integrative Multi-species Prediction

Drosophila melanogaster

98 known processes

scrt (Dmel_CG1130)

scratch

(Aliases: Scrt,anon-EST:Liang-1.31,Dmel\CG1130,BcDNA:RH71479,clone 1.67,CG1130,anon-EST:Liang-1.67,anon-WO02059370.57,clone 1.31)

Entrez: 38469
FLYBASE: FBgn0004880
UniProtKB: Q9VZK2

Process Predictions
Disease Predictions

scrt biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
eye development	GO:0001654	323	0.469	Fly
regulation of multicellular organismal development	GO:2000026	414	0.337	Mouse
photoreceptor cell differentiation	GO:0046530	170	0.274
post embryonic appendage morphogenesis	GO:0035120	385	0.264
respiratory system development	GO:0060541	213	0.258	Fly
compound eye development	GO:0048749	307	0.253	Fly
microtubule based transport	GO:0010970	42	0.251
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.243
imaginal disc derived appendage development	GO:0048737	399	0.226
dendrite development	GO:0016358	204	0.207
negative regulation of cell differentiation	GO:0045596	143	0.204	Fly
positive regulation of signal transduction	GO:0009967	223	0.164
appendage development	GO:0048736	401	0.154
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.152
positive regulation of cell communication	GO:0010647	250	0.152
positive regulation of response to stimulus	GO:0048584	323	0.144
regionalization	GO:0003002	416	0.141
appendage morphogenesis	GO:0035107	397	0.137
negative regulation of multicellular organismal process	GO:0051241	142	0.134
immune response	GO:0006955	246	0.132
positive regulation of signaling	GO:0023056	243	0.131
wing disc morphogenesis	GO:0007472	344	0.127
single organism intracellular transport	GO:1902582	207	0.126
sensory organ morphogenesis	GO:0090596	260	0.123
body morphogenesis	GO:0010171	2	0.122
dendrite morphogenesis	GO:0048813	199	0.119
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.112
cell proliferation	GO:0008283	299	0.109	Fly
eye photoreceptor cell fate commitment	GO:0042706	37	0.107
gland development	GO:0048732	191	0.104
regulation of embryonic development	GO:0045995	68	0.099
cell fate specification	GO:0001708	71	0.098	Fly
olfactory behavior	GO:0042048	97	0.095	Fly
intracellular signal transduction	GO:0035556	300	0.093
establishment or maintenance of cell polarity	GO:0007163	167	0.092
associative learning	GO:0008306	65	0.088
chemosensory behavior	GO:0007635	106	0.085	Fly
axis specification	GO:0009798	167	0.085
cytokinesis	GO:0000910	90	0.082
establishment of organelle localization	GO:0051656	122	0.080
imaginal disc derived wing morphogenesis	GO:0007476	337	0.080
regulation of cell differentiation	GO:0045595	302	0.079	Mouse Fly
oocyte construction	GO:0007308	112	0.078
regulation of phosphate metabolic process	GO:0019220	210	0.073
compound eye morphogenesis	GO:0001745	249	0.072
immune system process	GO:0002376	347	0.072
microtubule based movement	GO:0007018	51	0.071
compound eye photoreceptor fate commitment	GO:0001752	36	0.068
intracellular transport	GO:0046907	228	0.067
death	GO:0016265	284	0.067	Worm
cellular nitrogen compound catabolic process	GO:0044270	165	0.066
regulation of cellular catabolic process	GO:0031329	157	0.066
ras protein signal transduction	GO:0007265	88	0.065
glycosyl compound catabolic process	GO:1901658	112	0.064
regulation of cell proliferation	GO:0042127	163	0.064
neuron projection guidance	GO:0097485	241	0.064
regulation of cellular protein metabolic process	GO:0032268	243	0.062	Fly
olfactory learning	GO:0008355	56	0.059
axon guidance	GO:0007411	233	0.059
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.058	Fly
regulation of cellular amino acid metabolic process	GO:0006521	0	0.057
autophagy	GO:0006914	108	0.057
negative regulation of cell development	GO:0010721	62	0.057
purine nucleoside metabolic process	GO:0042278	127	0.056
kidney development	GO:0001822	3	0.056
phosphorylation	GO:0016310	294	0.055
axonogenesis	GO:0007409	290	0.054
regulation of bmp signaling pathway	GO:0030510	23	0.054
positive regulation of intracellular signal transduction	GO:1902533	116	0.054
regulation of intracellular signal transduction	GO:1902531	236	0.053
cytoskeleton dependent intracellular transport	GO:0030705	44	0.053
mitotic cytokinesis	GO:0000281	50	0.053
negative regulation of cellular metabolic process	GO:0031324	382	0.053
protein complex biogenesis	GO:0070271	201	0.053
nucleobase containing compound catabolic process	GO:0034655	165	0.051
aromatic compound catabolic process	GO:0019439	166	0.048
cell cell adhesion	GO:0098609	26	0.048
actin cytoskeleton organization	GO:0030036	206	0.047
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.047
oocyte differentiation	GO:0009994	145	0.047
central nervous system development	GO:0007417	201	0.047	Fly
regulation of phosphorus metabolic process	GO:0051174	210	0.047
eye morphogenesis	GO:0048592	260	0.046
response to external biotic stimulus	GO:0043207	293	0.046
dorsal ventral pattern formation	GO:0009953	133	0.046
organelle localization	GO:0051640	148	0.045
regulation of anatomical structure morphogenesis	GO:0022603	242	0.045
camera type eye development	GO:0043010	4	0.043
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.043	Fly
anterior posterior pattern specification	GO:0009952	136	0.043
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.043
imaginal disc derived leg morphogenesis	GO:0007480	80	0.042
positive regulation of cellular biosynthetic process	GO:0031328	316	0.042	Fly
ovarian follicle cell development	GO:0030707	248	0.041
oocyte axis specification	GO:0007309	108	0.041
negative regulation of developmental process	GO:0051093	201	0.041	Fly
gliogenesis	GO:0042063	80	0.040
negative regulation of response to stimulus	GO:0048585	258	0.040
neurological system process	GO:0050877	358	0.040
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.040
organophosphate catabolic process	GO:0046434	112	0.039
regulation of reproductive process	GO:2000241	54	0.038
heterocycle catabolic process	GO:0046700	166	0.037
regulation of protein metabolic process	GO:0051246	256	0.037	Fly
asymmetric cell division	GO:0008356	37	0.037
positive regulation of biosynthetic process	GO:0009891	316	0.036	Fly
establishment of localization in cell	GO:0051649	402	0.036
cytoskeleton dependent cytokinesis	GO:0061640	81	0.035
cellular catabolic process	GO:0044248	372	0.034
regulation of cellular ketone metabolic process	GO:0010565	3	0.034
purine ribonucleotide catabolic process	GO:0009154	109	0.034
head development	GO:0060322	135	0.033	Fly
regulation of notch signaling pathway	GO:0008593	100	0.033
ribonucleoside metabolic process	GO:0009119	127	0.033
response to gravity	GO:0009629	26	0.033	Fly
connective tissue development	GO:0061448	3	0.032
developmental maturation	GO:0021700	172	0.032
purine ribonucleotide metabolic process	GO:0009150	145	0.032
tube development	GO:0035295	244	0.032	Fly
organonitrogen compound metabolic process	GO:1901564	318	0.032
regulation of catalytic activity	GO:0050790	185	0.032
immune effector process	GO:0002252	98	0.032
negative regulation of cellular component organization	GO:0051129	108	0.032
protein phosphorylation	GO:0006468	169	0.031
regulation of peptidase activity	GO:0052547	39	0.031
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.031
eye photoreceptor cell differentiation	GO:0001754	145	0.031
regulation of proteolysis	GO:0030162	87	0.030
sensory perception of sound	GO:0007605	56	0.030
regulation of anatomical structure size	GO:0090066	163	0.029
regulation of phosphorylation	GO:0042325	147	0.029
positive regulation of macromolecule metabolic process	GO:0010604	405	0.029	Fly
glycosyl compound metabolic process	GO:1901657	127	0.029
purine containing compound metabolic process	GO:0072521	155	0.028
epithelial cell migration	GO:0010631	148	0.028	Fly
segmentation	GO:0035282	207	0.028
hindbrain development	GO:0030902	2	0.028
embryonic morphogenesis	GO:0048598	206	0.027	Fly
nucleoside triphosphate metabolic process	GO:0009141	120	0.027
epithelial cell differentiation	GO:0030855	322	0.027
vesicle mediated transport	GO:0016192	381	0.026
organic cyclic compound catabolic process	GO:1901361	168	0.026
leg disc morphogenesis	GO:0007478	80	0.026
homeostatic process	GO:0042592	199	0.026
single organism catabolic process	GO:0044712	228	0.026
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.026
programmed cell death	GO:0012501	257	0.026	Worm
r7 cell differentiation	GO:0045466	43	0.025
regulation of cell death	GO:0010941	173	0.025	Worm
cytoplasmic microtubule organization	GO:0031122	22	0.025
morphogenesis of embryonic epithelium	GO:0016331	94	0.025
organic substance catabolic process	GO:1901575	308	0.025
compound eye photoreceptor cell differentiation	GO:0001751	140	0.025
branching involved in open tracheal system development	GO:0060446	45	0.025	Fly
negative regulation of signaling	GO:0023057	219	0.024
nucleoside phosphate metabolic process	GO:0006753	162	0.024
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.024
cellular protein modification process	GO:0006464	438	0.024	Fly
gravitaxis	GO:0042332	26	0.024	Fly
morphogenesis of an epithelium	GO:0002009	276	0.023	Fly
regulation of multi organism process	GO:0043900	131	0.023
gtp metabolic process	GO:0046039	72	0.023
axon development	GO:0061564	297	0.023
negative regulation of cellular protein metabolic process	GO:0032269	85	0.023
humoral immune response	GO:0006959	117	0.022
actin filament based process	GO:0030029	220	0.022
nucleoside metabolic process	GO:0009116	127	0.022
purine nucleotide metabolic process	GO:0006163	146	0.021
regulation of wnt signaling pathway	GO:0030111	68	0.021
cell death	GO:0008219	279	0.021	Worm
carboxylic acid metabolic process	GO:0019752	92	0.021
positive regulation of molecular function	GO:0044093	136	0.021
gland morphogenesis	GO:0022612	145	0.021
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.021
calcium ion homeostasis	GO:0055074	23	0.020
response to biotic stimulus	GO:0009607	294	0.020
negative regulation of molecular function	GO:0044092	51	0.020
notch signaling pathway	GO:0007219	120	0.020
response to alcohol	GO:0097305	95	0.020
retina development in camera type eye	GO:0060041	4	0.020
epithelial cell development	GO:0002064	274	0.020
macromolecular complex assembly	GO:0065003	256	0.020
mapk cascade	GO:0000165	107	0.020
cell adhesion	GO:0007155	136	0.020
cytoplasmic transport	GO:0016482	130	0.019
skin development	GO:0043588	65	0.019
regulation of neurogenesis	GO:0050767	158	0.019	Mouse
regulation of retinal cell programmed cell death	GO:0046668	18	0.019
organ growth	GO:0035265	56	0.019
positive regulation of mapk cascade	GO:0043410	63	0.019
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.019
erbb signaling pathway	GO:0038127	58	0.019
negative regulation of cell communication	GO:0010648	223	0.019
stem cell development	GO:0048864	79	0.018	Fly
catabolic process	GO:0009056	409	0.018
negative regulation of cell proliferation	GO:0008285	69	0.018
ion homeostasis	GO:0050801	55	0.018
dephosphorylation	GO:0016311	51	0.018
biological adhesion	GO:0022610	138	0.018
positive regulation of phosphorylation	GO:0042327	87	0.018
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.018
positive regulation of phosphorus metabolic process	GO:0010562	139	0.018
regulation of erbb signaling pathway	GO:1901184	42	0.018
regulation of immune system process	GO:0002682	176	0.018
small molecule metabolic process	GO:0044281	305	0.018
peripheral nervous system development	GO:0007422	52	0.018
organophosphate metabolic process	GO:0019637	195	0.018
mitotic nuclear division	GO:0007067	213	0.017
imaginal disc pattern formation	GO:0007447	91	0.017
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.017
regulation of hydrolase activity	GO:0051336	97	0.017
chaeta development	GO:0022416	97	0.017
regulation of catabolic process	GO:0009894	170	0.017
protein localization	GO:0008104	284	0.017
single organism cell adhesion	GO:0098602	47	0.017
transcription from rna polymerase ii promoter	GO:0006366	368	0.017
peptidyl tyrosine modification	GO:0018212	24	0.017
nucleotide catabolic process	GO:0009166	109	0.017
brain development	GO:0007420	120	0.017	Fly
positive regulation of catabolic process	GO:0009896	105	0.017
dna metabolic process	GO:0006259	227	0.017	Fly
neural retina development	GO:0003407	4	0.017
regulation of immune response	GO:0050776	118	0.017
cell fate determination	GO:0001709	91	0.017	Fly
protein complex assembly	GO:0006461	200	0.017
salivary gland development	GO:0007431	162	0.016
regulation of cellular response to stress	GO:0080135	89	0.016
positive regulation of catalytic activity	GO:0043085	118	0.016
tripartite regional subdivision	GO:0007351	103	0.016
positive regulation of cell proliferation	GO:0008284	47	0.016
exocrine system development	GO:0035272	162	0.016
negative regulation of nervous system development	GO:0051961	92	0.016
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.016
cation transport	GO:0006812	110	0.016
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.016	Fly
endomembrane system organization	GO:0010256	119	0.016
regulation of response to biotic stimulus	GO:0002831	63	0.016
negative regulation of epithelial cell proliferation	GO:0050680	4	0.016
epidermis development	GO:0008544	65	0.016
forebrain development	GO:0030900	2	0.016
blastoderm segmentation	GO:0007350	159	0.016
cell division	GO:0051301	248	0.016	Fly
negative regulation of signal transduction	GO:0009968	206	0.016
muscle structure development	GO:0061061	224	0.016	Fly
apoptotic process	GO:0006915	159	0.016
protein modification process	GO:0036211	438	0.015	Fly
regulation of epithelial cell proliferation	GO:0050678	4	0.015
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.015	Fly
regulation of cellular component biogenesis	GO:0044087	201	0.015
positive regulation of phosphate metabolic process	GO:0045937	139	0.015
purine containing compound catabolic process	GO:0072523	112	0.015
guanosine containing compound catabolic process	GO:1901069	74	0.015
embryonic pattern specification	GO:0009880	174	0.015
negative regulation of programmed cell death	GO:0043069	72	0.015	Worm
negative regulation of rna biosynthetic process	GO:1902679	240	0.015
tissue morphogenesis	GO:0048729	297	0.015	Fly
regulation of epidermal growth factor activated receptor activity	GO:0007176	4	0.015
negative regulation of gene expression	GO:0010629	387	0.015
negative regulation of transcription dna templated	GO:0045892	237	0.014
organic substance transport	GO:0071702	257	0.014
guanosine containing compound metabolic process	GO:1901068	74	0.014
nucleotide metabolic process	GO:0009117	161	0.014
negative regulation of apoptotic process	GO:0043066	63	0.014
amine metabolic process	GO:0009308	12	0.014
nucleoside triphosphate catabolic process	GO:0009143	108	0.014
digestive system development	GO:0055123	149	0.014	Fly
purine ribonucleoside catabolic process	GO:0046130	112	0.014
renal system development	GO:0072001	72	0.014	Fly
proteolysis	GO:0006508	192	0.014
regulation of cell development	GO:0060284	215	0.014	Mouse
cell maturation	GO:0048469	144	0.014
anterior posterior axis specification	GO:0009948	109	0.014
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.014
negative regulation of erk1 and erk2 cascade	GO:0070373	3	0.013
cellular amine metabolic process	GO:0044106	12	0.013
immune system development	GO:0002520	57	0.013
sister chromatid segregation	GO:0000819	92	0.013
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.013
regulation of cellular component size	GO:0032535	98	0.013
homophilic cell adhesion via plasma membrane adhesion molecules	GO:0007156	18	0.013
startle response	GO:0001964	16	0.013
single organism biosynthetic process	GO:0044711	206	0.013	Fly
digestive tract morphogenesis	GO:0048546	127	0.013	Fly
ribonucleotide catabolic process	GO:0009261	109	0.013
developmental growth involved in morphogenesis	GO:0060560	65	0.013
protein maturation	GO:0051604	71	0.013
endosomal transport	GO:0016197	44	0.013
small gtpase mediated signal transduction	GO:0007264	88	0.013
pole plasm mrna localization	GO:0019094	49	0.013
neuron fate commitment	GO:0048663	50	0.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.013
carbohydrate derivative catabolic process	GO:1901136	118	0.012
regulation of mitotic cell cycle	GO:0007346	190	0.012
nucleoside phosphate catabolic process	GO:1901292	110	0.012
positive regulation of protein metabolic process	GO:0051247	128	0.012	Fly
purine ribonucleoside metabolic process	GO:0046128	127	0.012
regulation of epithelial cell differentiation	GO:0030856	4	0.012
response to other organism	GO:0051707	293	0.012
salivary gland morphogenesis	GO:0007435	145	0.012
cell cycle arrest	GO:0007050	4	0.012
ribonucleoside catabolic process	GO:0042454	112	0.012
purine nucleoside catabolic process	GO:0006152	112	0.012
tube morphogenesis	GO:0035239	191	0.012	Fly
regulation of transferase activity	GO:0051338	58	0.011
neuron recognition	GO:0008038	101	0.011
regulation of mrna metabolic process	GO:1903311	72	0.011
larval development	GO:0002164	104	0.011
filopodium assembly	GO:0046847	33	0.011
response to organic substance	GO:0010033	284	0.011
learning	GO:0007612	75	0.011
anterior posterior axis specification embryo	GO:0008595	103	0.011
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.011
photoreceptor cell fate commitment	GO:0046552	41	0.011
rna splicing via transesterification reactions	GO:0000375	73	0.011
positive regulation of cell death	GO:0010942	69	0.011
nephron epithelium development	GO:0072009	3	0.011
hemopoiesis	GO:0030097	46	0.011
gene silencing	GO:0016458	138	0.011
regulation of gtp catabolic process	GO:0033124	44	0.011
protein processing	GO:0016485	68	0.011
ncrna metabolic process	GO:0034660	43	0.011
regulation of endopeptidase activity	GO:0052548	36	0.011
endocytosis	GO:0006897	310	0.011
positive regulation of immune system process	GO:0002684	68	0.010
regulation of mitosis	GO:0007088	56	0.010
regulation of nucleotide catabolic process	GO:0030811	48	0.010
nucleobase containing small molecule metabolic process	GO:0055086	174	0.010
signal transduction by phosphorylation	GO:0023014	107	0.010
regulation of cell projection assembly	GO:0060491	30	0.010
positive regulation of cellular catabolic process	GO:0031331	95	0.010

scrt disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	nervous system disease	DOID:863	0	0.010
	disease of anatomical entity	DOID:7	0	0.010

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