IMP: Integrative Multi-species Prediction

Drosophila melanogaster

236 known processes

Ca-P60A (Dmel_CG3725)

Calcium ATPase at 60A

(Aliases: dSERCA,CG3725,SERCA2,l(2)k08308ab,CA-P60A,Ca-P60,CaP60A,Dmel\CG3725,Ca-p,Kum,Ca[2+]ATPase,Ca-ATPase,SERCA,l(2)k09025,Serca2a)

FLYBASE: FBgn0004551
Entrez: 49297
UniProtKB: P22700
UniProtKB: E8NHA8

Process Predictions
Disease Predictions

Ca-P60A biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cation transport	GO:0006812	110	0.947
cation transmembrane transport	GO:0098655	88	0.892
single organism intracellular transport	GO:1902582	207	0.743	Rat
ion transport	GO:0006811	145	0.713
striated muscle myosin thick filament assembly	GO:0071688	3	0.689	Worm
regulation of localization	GO:0032879	275	0.678
metal ion transport	GO:0030001	74	0.674
embryo development ending in birth or egg hatching	GO:0009792	152	0.617	Worm
cellular catabolic process	GO:0044248	372	0.561
oxoacid metabolic process	GO:0043436	103	0.551
response to abiotic stimulus	GO:0009628	341	0.530	Zebrafish
vesicle mediated transport	GO:0016192	381	0.521	Worm
actomyosin structure organization	GO:0031032	56	0.463	Worm
actin filament based process	GO:0030029	220	0.401	Worm
homeostatic process	GO:0042592	199	0.396
regulation of intracellular transport	GO:0032386	64	0.384
oxidation reduction process	GO:0055114	123	0.379
monovalent inorganic cation transport	GO:0015672	40	0.368
eye development	GO:0001654	323	0.350
regulation of ion transport	GO:0043269	39	0.321
catabolic process	GO:0009056	409	0.289
regulation of metal ion transport	GO:0010959	15	0.283
cytoplasmic transport	GO:0016482	130	0.282	Rat
response to oxidative stress	GO:0006979	86	0.282
actin cytoskeleton organization	GO:0030036	206	0.271	Worm
chemical homeostasis	GO:0048878	92	0.268
regulation of cell proliferation	GO:0042127	163	0.228
establishment of localization in cell	GO:0051649	402	0.225	Mouse Rat
metal ion homeostasis	GO:0055065	44	0.197
wing disc morphogenesis	GO:0007472	344	0.197
growth	GO:0040007	359	0.175
maintenance of location	GO:0051235	73	0.175
inorganic cation transmembrane transport	GO:0098662	61	0.174
myofibril assembly	GO:0030239	36	0.173	Worm
organic acid metabolic process	GO:0006082	103	0.170
neurotransmitter transport	GO:0006836	37	0.168	Mouse
nucleoside triphosphate metabolic process	GO:0009141	120	0.156
imaginal disc derived wing morphogenesis	GO:0007476	337	0.153
appendage morphogenesis	GO:0035107	397	0.146
endocytosis	GO:0006897	310	0.145	Worm
appendage development	GO:0048736	401	0.135
larval development	GO:0002164	104	0.134	Worm
cellular lipid metabolic process	GO:0044255	83	0.128
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.127
carboxylic acid metabolic process	GO:0019752	92	0.121
regulation of transport	GO:0051049	181	0.121
inorganic ion transmembrane transport	GO:0098660	73	0.120
death	GO:0016265	284	0.118	Worm
ion transmembrane transport	GO:0034220	122	0.113
cellular homeostasis	GO:0019725	80	0.112
striated muscle cell development	GO:0055002	50	0.109	Worm
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.108
organophosphate metabolic process	GO:0019637	195	0.107
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.107
post embryonic appendage morphogenesis	GO:0035120	385	0.106
atp metabolic process	GO:0046034	49	0.106
establishment of protein localization	GO:0045184	163	0.105
regulation of cell differentiation	GO:0045595	302	0.103
phagocytosis	GO:0006909	215	0.102
carbohydrate derivative catabolic process	GO:1901136	118	0.101
cell division	GO:0051301	248	0.091
positive regulation of transport	GO:0051050	92	0.091
endomembrane system organization	GO:0010256	119	0.091
cellular chemical homeostasis	GO:0055082	40	0.091
regulation of cytoplasmic transport	GO:1903649	47	0.090
lipid localization	GO:0010876	54	0.088
potassium ion transport	GO:0006813	20	0.086
negative regulation of mitotic cell cycle	GO:0045930	109	0.086
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.085
single organism biosynthetic process	GO:0044711	206	0.084
cellular component assembly involved in morphogenesis	GO:0010927	151	0.081	Worm
regulation of notch signaling pathway	GO:0008593	100	0.076
divalent inorganic cation homeostasis	GO:0072507	29	0.073
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.071
myosin filament assembly	GO:0031034	5	0.071	Worm
single organism cellular localization	GO:1902580	180	0.071
response to extracellular stimulus	GO:0009991	116	0.070	Worm
single organism catabolic process	GO:0044712	228	0.069
cellular cation homeostasis	GO:0030003	38	0.067
nucleoside monophosphate metabolic process	GO:0009123	52	0.067
camera type eye development	GO:0043010	4	0.067
small molecule metabolic process	GO:0044281	305	0.067
myotube cell development	GO:0014904	3	0.064
nucleotide metabolic process	GO:0009117	161	0.063
positive regulation of protein import into nucleus	GO:0042307	21	0.063
negative regulation of epithelial cell proliferation	GO:0050680	4	0.063
energy derivation by oxidation of organic compounds	GO:0015980	32	0.061
purine ribonucleotide catabolic process	GO:0009154	109	0.061
response to decreased oxygen levels	GO:0036293	58	0.060
neuromuscular junction development	GO:0007528	149	0.058
muscle structure development	GO:0061061	224	0.057	Worm
regulation of system process	GO:0044057	36	0.056	Human Zebrafish Mouse Rat
glycosyl compound catabolic process	GO:1901658	112	0.056
protein transport	GO:0015031	155	0.056
regulation of mitotic cell cycle	GO:0007346	190	0.054
protein complex assembly	GO:0006461	200	0.054	Worm
cellular ion homeostasis	GO:0006873	39	0.053
cellular response to chemical stimulus	GO:0070887	199	0.053	Worm
organelle fission	GO:0048285	340	0.053
muscle contraction	GO:0006936	13	0.052	Human Zebrafish Rat
heart development	GO:0007507	82	0.052	Zebrafish
positive regulation of protein localization to nucleus	GO:1900182	21	0.052
aging	GO:0007568	143	0.052	Worm
multicellular organismal signaling	GO:0035637	12	0.051
nucleoside phosphate catabolic process	GO:1901292	110	0.050
muscle system process	GO:0003012	21	0.049	Human Zebrafish Mouse Rat
determination of adult lifespan	GO:0008340	137	0.049	Worm
nucleobase containing compound catabolic process	GO:0034655	165	0.048
body morphogenesis	GO:0010171	2	0.047
cation homeostasis	GO:0055080	51	0.047
flight behavior	GO:0007629	26	0.046
imaginal disc derived appendage development	GO:0048737	399	0.046
cell death	GO:0008219	279	0.046	Worm
organic substance transport	GO:0071702	257	0.045
fatty acid oxidation	GO:0019395	6	0.045
detection of light stimulus	GO:0009583	58	0.045
programmed cell death	GO:0012501	257	0.045	Worm
response to heat	GO:0009408	63	0.045
positive regulation of atp catabolic process	GO:1903291	3	0.044
synapse organization	GO:0050808	196	0.044
cell cycle phase transition	GO:0044770	140	0.044
single organism carbohydrate metabolic process	GO:0044723	72	0.043
regulation of nucleocytoplasmic transport	GO:0046822	35	0.043
cellular protein modification process	GO:0006464	438	0.043
regulation of cell cycle process	GO:0010564	181	0.042
response to nutrient levels	GO:0031667	114	0.042	Worm
nucleoside phosphate metabolic process	GO:0006753	162	0.040
intracellular protein transport	GO:0006886	104	0.040
regulation of growth	GO:0040008	233	0.040
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.039
multicellular organismal aging	GO:0010259	140	0.039	Worm
regionalization	GO:0003002	416	0.039
neuronal action potential	GO:0019228	10	0.039
circulatory system process	GO:0003013	37	0.039
organic substance catabolic process	GO:1901575	308	0.038
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.038
cell proliferation	GO:0008283	299	0.036
secretion	GO:0046903	109	0.035	Mouse
regulation of ion transmembrane transport	GO:0034765	27	0.035
eye morphogenesis	GO:0048592	260	0.035
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.035
regulation of protein complex disassembly	GO:0043244	29	0.035
regulation of cellular component movement	GO:0051270	42	0.034	Rat
regulation of cellular localization	GO:0060341	136	0.034	Mouse
skeletal muscle fiber development	GO:0048741	3	0.034
atp catabolic process	GO:0006200	38	0.033
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.033
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.033
membrane organization	GO:0061024	112	0.033
positive regulation of molecular function	GO:0044093	136	0.033
single organism nuclear import	GO:1902593	51	0.032
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.032
striated muscle contraction	GO:0006941	5	0.032	Human Rat
protein localization to organelle	GO:0033365	82	0.031
regulation of protein transport	GO:0051223	57	0.031
response to alcohol	GO:0097305	95	0.030
ion homeostasis	GO:0050801	55	0.030
response to oxygen containing compound	GO:1901700	200	0.029	Rat
cellular calcium ion homeostasis	GO:0006874	21	0.029
cellular protein localization	GO:0034613	160	0.029
carbohydrate metabolic process	GO:0005975	82	0.029
organonitrogen compound catabolic process	GO:1901565	128	0.029
purine ribonucleoside catabolic process	GO:0046130	112	0.029
golgi to plasma membrane transport	GO:0006893	8	0.028
transcription from rna polymerase ii promoter	GO:0006366	368	0.028
inositol lipid mediated signaling	GO:0048017	4	0.028
protein import into nucleus	GO:0006606	51	0.028
chromosome organization	GO:0051276	360	0.027
purine ribonucleoside triphosphate biosynthetic process	GO:0009206	2	0.027
nucleobase containing small molecule metabolic process	GO:0055086	174	0.027
neurotransmitter receptor metabolic process	GO:0045213	3	0.026
protein targeting	GO:0006605	64	0.026
nuclear division	GO:0000280	332	0.026
mitotic nuclear division	GO:0007067	213	0.026
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.025
regulation of protein import into nucleus	GO:0042306	28	0.025
cytokinesis	GO:0000910	90	0.025
nuclear transport	GO:0051169	72	0.025
negative regulation of hormone biosynthetic process	GO:0032353	1	0.024
lipid metabolic process	GO:0006629	121	0.024
protein localization	GO:0008104	284	0.024
purine nucleoside metabolic process	GO:0042278	127	0.023
negative regulation of response to stimulus	GO:0048585	258	0.023
synaptic vesicle fusion to presynaptic membrane	GO:0031629	7	0.023
macromolecular complex assembly	GO:0065003	256	0.023	Worm
early endosome to late endosome transport	GO:0045022	3	0.022
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.022
purine nucleoside biosynthetic process	GO:0042451	3	0.022
purine ribonucleotide metabolic process	GO:0009150	145	0.022
glycosyl compound metabolic process	GO:1901657	127	0.022
regulation of multicellular organismal development	GO:2000026	414	0.022
protein complex biogenesis	GO:0070271	201	0.021	Worm
response to hypoxia	GO:0001666	53	0.021
positive regulation of intracellular transport	GO:0032388	42	0.021
transmembrane transport	GO:0055085	139	0.020
cellular respiration	GO:0045333	26	0.020
ribonucleoside triphosphate biosynthetic process	GO:0009201	2	0.020
regulation of vesicle mediated transport	GO:0060627	59	0.020
striated muscle cell differentiation	GO:0051146	90	0.019	Worm
embryonic morphogenesis	GO:0048598	206	0.019	Zebrafish
protein catabolic process	GO:0030163	101	0.019
hexose metabolic process	GO:0019318	8	0.019
purine nucleoside catabolic process	GO:0006152	112	0.019
cellular potassium ion transport	GO:0071804	18	0.019
positive regulation of developmental process	GO:0051094	143	0.019
divalent metal ion transport	GO:0070838	26	0.019
myosin filament organization	GO:0031033	5	0.018	Worm
negative regulation of cell communication	GO:0010648	223	0.018
regulation of cell death	GO:0010941	173	0.018
detection of stimulus involved in sensory perception	GO:0050906	92	0.018
organophosphate catabolic process	GO:0046434	112	0.018
regulation of protein localization	GO:0032880	76	0.018
notch signaling pathway	GO:0007219	120	0.018
regulation of organelle organization	GO:0033043	196	0.018
extrinsic apoptotic signaling pathway	GO:0097191	1	0.017
transmission of nerve impulse	GO:0019226	12	0.017
carbohydrate derivative metabolic process	GO:1901135	217	0.017
striated muscle tissue development	GO:0014706	27	0.017
regulation of phosphatase activity	GO:0010921	3	0.017
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.017
response to temperature stimulus	GO:0009266	106	0.017
organelle assembly	GO:0070925	198	0.017	Worm
regulation of establishment of protein localization	GO:0070201	61	0.017
nucleoside monophosphate catabolic process	GO:0009125	39	0.017
positive regulation of intracellular protein transport	GO:0090316	30	0.017
chemotaxis	GO:0006935	249	0.017
negative regulation of cell proliferation	GO:0008285	69	0.017
muscle organ development	GO:0007517	127	0.016
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.016
single organism membrane organization	GO:0044802	93	0.016
negative regulation of cell differentiation	GO:0045596	143	0.016
multicellular organismal homeostasis	GO:0048871	41	0.016
regulation of protein targeting	GO:1903533	29	0.016
regulation of transcription factor import into nucleus	GO:0042990	22	0.015
response to light stimulus	GO:0009416	124	0.015
nicotinamide nucleotide metabolic process	GO:0046496	2	0.015
regulation of membrane potential	GO:0042391	35	0.015
regulation of neurotransmitter levels	GO:0001505	38	0.015	Mouse
regulation of rac gtpase activity	GO:0032314	1	0.015
purine ribonucleoside monophosphate biosynthetic process	GO:0009168	3	0.014
purine ribonucleoside biosynthetic process	GO:0046129	3	0.014
ribose phosphate metabolic process	GO:0019693	145	0.014
lipid modification	GO:0030258	24	0.014
regulation of cell cycle phase transition	GO:1901987	130	0.014
actin filament based movement	GO:0030048	26	0.014
detection of visible light	GO:0009584	38	0.014
organophosphate biosynthetic process	GO:0090407	46	0.014
receptor mediated endocytosis	GO:0006898	21	0.014	Worm
modification dependent protein catabolic process	GO:0019941	78	0.014
negative regulation of cell cycle phase transition	GO:1901988	103	0.013
cellular protein complex assembly	GO:0043623	71	0.013	Worm
retina development in camera type eye	GO:0060041	4	0.013
sensory organ morphogenesis	GO:0090596	260	0.013
lipid storage	GO:0019915	38	0.013
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.013
mitochondrion organization	GO:0007005	65	0.013
anatomical structure homeostasis	GO:0060249	97	0.013
regulation of intracellular protein transport	GO:0033157	46	0.013
humoral immune response	GO:0006959	117	0.013
regulation of protein localization to nucleus	GO:1900180	29	0.013
organonitrogen compound biosynthetic process	GO:1901566	117	0.013
protein modification process	GO:0036211	438	0.013
nucleoside metabolic process	GO:0009116	127	0.012
secretion by cell	GO:0032940	101	0.012	Mouse
response to endogenous stimulus	GO:0009719	119	0.012	Rat
protein targeting to nucleus	GO:0044744	51	0.012
synaptic vesicle recycling	GO:0036465	28	0.012
establishment of protein localization to organelle	GO:0072594	62	0.011
calcium ion homeostasis	GO:0055074	23	0.011
response to radiation	GO:0009314	155	0.011
regulation of cell cycle	GO:0051726	291	0.011
regulation of programmed cell death	GO:0043067	152	0.011
meiotic nuclear division	GO:0007126	151	0.011
regulation of synaptic plasticity	GO:0048167	14	0.011
nuclear import	GO:0051170	51	0.011
positive regulation of cell communication	GO:0010647	250	0.011
positive regulation of organelle organization	GO:0010638	65	0.010
response to drug	GO:0042493	17	0.010
regulation of protein stability	GO:0031647	43	0.010
positive regulation of cellular biosynthetic process	GO:0031328	316	0.010
cardiovascular system development	GO:0072358	82	0.010	Zebrafish
nucleocytoplasmic transport	GO:0006913	72	0.010
regulation of blood circulation	GO:1903522	21	0.010	Human Zebrafish Mouse Rat

Ca-P60A disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.085	Human
musculoskeletal system disease	DOID:17	0.017
muscle tissue disease	DOID:66	0.013
muscular disease	DOID:0080000	0.013

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