IMP: Integrative Multi-species Prediction

Drosophila melanogaster

64 known processes

Traf6 (Dmel_CG10961)

TNF-receptor-associated factor 6

(Aliases: TRAF2,TRAF,TRAF6,dtraf2,Traf2,dTRAF6,dTraf2,DTRAF2,Dmel\CG10961,CG10961,dTRAF2)

FLYBASE: FBgn0026318
Entrez: 31746
UniProtKB: Q9W3I9

Process Predictions
Disease Predictions

Traf6 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
immune system process	GO:0002376	347	0.620
catabolic process	GO:0009056	409	0.386
establishment of localization in cell	GO:0051649	402	0.359
immune response	GO:0006955	246	0.317
defense response	GO:0006952	300	0.265
cellular response to extracellular stimulus	GO:0031668	64	0.255
defense response to other organism	GO:0098542	225	0.240
immune effector process	GO:0002252	98	0.237
regulation of transport	GO:0051049	181	0.232
mucosal immune response	GO:0002385	10	0.230
cellular response to chemical stimulus	GO:0070887	199	0.209
cytoplasmic transport	GO:0016482	130	0.208
regulation of response to external stimulus	GO:0032101	115	0.206
response to abiotic stimulus	GO:0009628	341	0.201
response to biotic stimulus	GO:0009607	294	0.196
response to external biotic stimulus	GO:0043207	293	0.196
humoral immune response	GO:0006959	117	0.195
negative regulation of cellular metabolic process	GO:0031324	382	0.191
autophagy	GO:0006914	108	0.189
regulation of immune response	GO:0050776	118	0.189
regulation of multi organism process	GO:0043900	131	0.187
regulation of cell death	GO:0010941	173	0.182	Fly
response to other organism	GO:0051707	293	0.180
cellular catabolic process	GO:0044248	372	0.175
antimicrobial humoral response	GO:0019730	99	0.174
histone modification	GO:0016570	106	0.166
innate immune response	GO:0045087	144	0.159
covalent chromatin modification	GO:0016569	106	0.157
regulation of defense response	GO:0031347	102	0.156
embryonic morphogenesis	GO:0048598	206	0.155	Fly
negative regulation of cellular biosynthetic process	GO:0031327	277	0.154
regulation of intracellular signal transduction	GO:1902531	236	0.150
taxis	GO:0042330	304	0.145
membrane organization	GO:0061024	112	0.144
regulation of apoptotic process	GO:0042981	130	0.139	Fly
regulation of immune effector process	GO:0002697	52	0.132
chromatin modification	GO:0016568	147	0.129
cellular protein modification process	GO:0006464	438	0.129
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.128
regulation of programmed cell death	GO:0043067	152	0.126	Fly
aging	GO:0007568	143	0.118
positive regulation of developmental process	GO:0051094	143	0.117
protein localization	GO:0008104	284	0.115	Fly
regulation of cellular response to stress	GO:0080135	89	0.112	Fly
regulation of antimicrobial humoral response	GO:0002759	50	0.108
defense response to bacterium	GO:0042742	178	0.108	Fly
epithelial cell development	GO:0002064	274	0.105	Fly
positive regulation of response to stimulus	GO:0048584	323	0.104	Fly
positive regulation of immune response	GO:0050778	63	0.100
intracellular signal transduction	GO:0035556	300	0.099
striated muscle cell differentiation	GO:0051146	90	0.096
epithelial cell differentiation	GO:0030855	322	0.094	Fly
regulation of cell cycle	GO:0051726	291	0.094
positive regulation of molecular function	GO:0044093	136	0.093
negative regulation of rna biosynthetic process	GO:1902679	240	0.093
nucleocytoplasmic transport	GO:0006913	72	0.093
imaginal disc derived appendage development	GO:0048737	399	0.093
muscle cell differentiation	GO:0042692	103	0.091
regulation of molecular function	GO:0065009	217	0.090
negative regulation of biosynthetic process	GO:0009890	277	0.089
regulation of response to stress	GO:0080134	200	0.089
cell motility	GO:0048870	251	0.087
regulation of cell differentiation	GO:0045595	302	0.087
digestive system development	GO:0055123	149	0.086	Fly
dorsal appendage formation	GO:0046843	47	0.086
histone acetylation	GO:0016573	38	0.084
phosphorylation	GO:0016310	294	0.084	Fly
regulation of immune system process	GO:0002682	176	0.083
muscle structure development	GO:0061061	224	0.083
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.083
positive regulation of transcription dna templated	GO:0045893	266	0.079
intracellular transport	GO:0046907	228	0.079
immune response activating signal transduction	GO:0002757	2	0.078
defense response to virus	GO:0051607	23	0.077
single organism intracellular transport	GO:1902582	207	0.077
regulation of cell cycle process	GO:0010564	181	0.076
response to starvation	GO:0042594	97	0.075
regulation of autophagy	GO:0010506	62	0.075
cellular response to nutrient levels	GO:0031669	62	0.074
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.073
regulation of nervous system development	GO:0051960	248	0.073
cation transport	GO:0006812	110	0.072
cellular response to starvation	GO:0009267	61	0.072
cell death	GO:0008219	279	0.072
programmed cell death	GO:0012501	257	0.072	Fly
protein localization to organelle	GO:0033365	82	0.071
dendrite morphogenesis	GO:0048813	199	0.071
antimicrobial peptide production	GO:0002775	46	0.070
establishment of protein localization	GO:0045184	163	0.070
regulation of production of molecular mediator of immune response	GO:0002700	44	0.068
stress activated mapk cascade	GO:0051403	52	0.067	Fly
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.065
response to endogenous stimulus	GO:0009719	119	0.061
endocytosis	GO:0006897	310	0.061	Fly
mitotic nuclear division	GO:0007067	213	0.061
regulation of anatomical structure size	GO:0090066	163	0.061
morphogenesis of an epithelium	GO:0002009	276	0.061
developmental programmed cell death	GO:0010623	138	0.061	Fly
growth	GO:0040007	359	0.061
eye development	GO:0001654	323	0.060	Fly
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.059
nuclear transport	GO:0051169	72	0.058
chromatin organization	GO:0006325	207	0.057
positive regulation of cell proliferation	GO:0008284	47	0.057
positive regulation of defense response	GO:0031349	59	0.057
organic acid metabolic process	GO:0006082	103	0.056
response to bacterium	GO:0009617	198	0.056	Fly
regulation of cellular catabolic process	GO:0031329	157	0.056
regulation of cellular component size	GO:0032535	98	0.055
organic substance transport	GO:0071702	257	0.055
histone h4 acetylation	GO:0043967	13	0.054
positive regulation of signal transduction	GO:0009967	223	0.054	Fly
single organism membrane organization	GO:0044802	93	0.054
organelle membrane fusion	GO:0090174	16	0.054
regulation of chromosome organization	GO:0033044	64	0.052
regulation of cellular protein metabolic process	GO:0032268	243	0.051
regulation of wnt signaling pathway	GO:0030111	68	0.051
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.051
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.051
protein transport	GO:0015031	155	0.050
regulation of defense response to virus by host	GO:0050691	10	0.050
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.050
heart process	GO:0003015	37	0.050
positive regulation of catalytic activity	GO:0043085	118	0.050
response to oxygen containing compound	GO:1901700	200	0.049
regulation of localization	GO:0032879	275	0.049
developmental pigmentation	GO:0048066	68	0.049
mrna splicing via spliceosome	GO:0000398	73	0.049
chemical homeostasis	GO:0048878	92	0.049
rna splicing	GO:0008380	83	0.049
negative regulation of cell differentiation	GO:0045596	143	0.048
regulation of mitotic cell cycle	GO:0007346	190	0.048
actin filament based process	GO:0030029	220	0.047	Fly
chromosome organization	GO:0051276	360	0.047
response to temperature stimulus	GO:0009266	106	0.047
dendrite development	GO:0016358	204	0.047
single fertilization	GO:0007338	24	0.047
eggshell chorion assembly	GO:0007306	66	0.047
immune response regulating signaling pathway	GO:0002764	2	0.046
death	GO:0016265	284	0.046
epithelium migration	GO:0090132	148	0.045
negative regulation of apoptotic process	GO:0043066	63	0.045
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.045
positive regulation of autophagy	GO:0010508	21	0.045
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.044
response to lipopolysaccharide	GO:0032496	4	0.044
response to nutrient levels	GO:0031667	114	0.044
cellular response to abiotic stimulus	GO:0071214	58	0.044
divalent metal ion transport	GO:0070838	26	0.044
central nervous system development	GO:0007417	201	0.043
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.042
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.042
positive regulation of catabolic process	GO:0009896	105	0.041
cellular protein localization	GO:0034613	160	0.041
positive regulation of multicellular organismal process	GO:0051240	143	0.041
response to extracellular stimulus	GO:0009991	116	0.041
regulation of cellular amine metabolic process	GO:0033238	3	0.040
chemotaxis	GO:0006935	249	0.040
intracellular protein transport	GO:0006886	104	0.040
protein import into nucleus	GO:0006606	51	0.040
positive regulation of transport	GO:0051050	92	0.039
protein localization to nucleus	GO:0034504	55	0.039
connective tissue development	GO:0061448	3	0.039
organic substance catabolic process	GO:1901575	308	0.039
localization of cell	GO:0051674	257	0.039
negative regulation of rna metabolic process	GO:0051253	251	0.039
negative regulation of programmed cell death	GO:0043069	72	0.038
brain development	GO:0007420	120	0.038
regulation of developmental growth	GO:0048638	174	0.038
protein acylation	GO:0043543	42	0.038
protein phosphorylation	GO:0006468	169	0.038
peptidyl amino acid modification	GO:0018193	105	0.038
positive regulation of biosynthetic process	GO:0009891	316	0.038
positive regulation of jun kinase activity	GO:0043507	4	0.038
homeostatic process	GO:0042592	199	0.037
cation homeostasis	GO:0055080	51	0.037
stem cell proliferation	GO:0072089	88	0.037
activation of innate immune response	GO:0002218	4	0.037
mitotic spindle organization	GO:0007052	220	0.037
response to radiation	GO:0009314	155	0.036
regulation of catalytic activity	GO:0050790	185	0.036
regulation of humoral immune response	GO:0002920	51	0.036
response to organic substance	GO:0010033	284	0.036
positive regulation of cell differentiation	GO:0045597	64	0.036
regulation of cell development	GO:0060284	215	0.036
metal ion homeostasis	GO:0055065	44	0.036
nephron development	GO:0072006	3	0.036
positive regulation of response to external stimulus	GO:0032103	44	0.036
regulation of cellular ketone metabolic process	GO:0010565	3	0.036
negative regulation of transcription dna templated	GO:0045892	237	0.035
chromatin remodeling	GO:0006338	72	0.035
positive regulation of macromolecule metabolic process	GO:0010604	405	0.035
regulation of ion transport	GO:0043269	39	0.035
axon guidance	GO:0007411	233	0.035
positive regulation of humoral immune response	GO:0002922	28	0.034
phagocytosis	GO:0006909	215	0.034	Fly
mrna metabolic process	GO:0016071	124	0.034
positive regulation of cellular protein metabolic process	GO:0032270	118	0.034
neuron projection guidance	GO:0097485	241	0.034
positive regulation of rna biosynthetic process	GO:1902680	266	0.034
positive regulation of cellular biosynthetic process	GO:0031328	316	0.033
positive regulation of cell size	GO:0045793	21	0.033
actin cytoskeleton organization	GO:0030036	206	0.033
positive regulation of signaling	GO:0023056	243	0.033	Fly
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.033
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.033
regulation of phosphate metabolic process	GO:0019220	210	0.032	Fly
forebrain development	GO:0030900	2	0.032
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.032
regulation of phosphorus metabolic process	GO:0051174	210	0.032	Fly
regulation of defense response to virus	GO:0050688	14	0.032
apoptotic process	GO:0006915	159	0.032	Fly
cell adhesion	GO:0007155	136	0.032
nuclear import	GO:0051170	51	0.032
negative regulation of signal transduction	GO:0009968	206	0.032
production of molecular mediator of immune response	GO:0002440	46	0.032
regulation of protein modification process	GO:0031399	112	0.032
digestive tract development	GO:0048565	149	0.031	Fly
protein targeting to nucleus	GO:0044744	51	0.031
positive regulation of cell communication	GO:0010647	250	0.031	Fly
negative regulation of developmental process	GO:0051093	201	0.031
positive regulation of gene expression	GO:0010628	290	0.031
axonogenesis	GO:0007409	290	0.031
regulation of intracellular transport	GO:0032386	64	0.031
regulation of mapk cascade	GO:0043408	92	0.030	Fly
negative regulation of cell cycle	GO:0045786	116	0.030
axon development	GO:0061564	297	0.030
regulation of cytoplasmic transport	GO:1903649	47	0.030
regulation of bmp signaling pathway	GO:0030510	23	0.029
protein catabolic process	GO:0030163	101	0.029
adult chitin containing cuticle pigmentation	GO:0048085	16	0.029
gastrulation	GO:0007369	70	0.029	Fly
cell cycle checkpoint	GO:0000075	95	0.029
regulation of stress activated mapk cascade	GO:0032872	41	0.029	Fly
response to wounding	GO:0009611	94	0.029
myotube cell development	GO:0014904	3	0.028
antibacterial humoral response	GO:0019731	44	0.028
dorsal closure	GO:0007391	79	0.028
regulation of protein metabolic process	GO:0051246	256	0.028
regulation of innate immune response	GO:0045088	71	0.028
cell cycle phase transition	GO:0044770	140	0.028
cellular response to oxygen containing compound	GO:1901701	79	0.028
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.028
protein modification process	GO:0036211	438	0.028
telencephalon development	GO:0021537	2	0.028
nuclear division	GO:0000280	332	0.028
positive regulation of protein import into nucleus	GO:0042307	21	0.028
wing disc morphogenesis	GO:0007472	344	0.028
lateral inhibition	GO:0046331	206	0.027
regulation of catabolic process	GO:0009894	170	0.027
spermatid development	GO:0007286	98	0.027
small molecule metabolic process	GO:0044281	305	0.027
histolysis	GO:0007559	102	0.027	Fly
cell migration	GO:0016477	238	0.027
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.027	Fly
cardiocyte differentiation	GO:0035051	29	0.027
head development	GO:0060322	135	0.027
cellular response to organic substance	GO:0071310	132	0.027
melanization defense response	GO:0035006	45	0.026
regulation of cell cycle phase transition	GO:1901987	130	0.026
neurological system process	GO:0050877	358	0.026
ribonucleoprotein complex biogenesis	GO:0022613	31	0.026
circulatory system development	GO:0072359	82	0.026
cell maturation	GO:0048469	144	0.026
positive regulation of protein metabolic process	GO:0051247	128	0.026
antibacterial peptide production	GO:0002778	22	0.026
cell proliferation	GO:0008283	299	0.026
response to organophosphorus	GO:0046683	2	0.026
regulation of defense response to bacterium	GO:1900424	30	0.026
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.026
columnar cuboidal epithelial cell development	GO:0002066	249	0.025
vesicle mediated transport	GO:0016192	381	0.025	Fly
positive regulation of hydrolase activity	GO:0051345	78	0.025
positive regulation of intracellular signal transduction	GO:1902533	116	0.025	Fly
positive regulation of defense response to virus by host	GO:0002230	10	0.025
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.025
organelle localization	GO:0051640	148	0.025
response to nitrogen compound	GO:1901698	90	0.025
ovarian follicle cell development	GO:0030707	248	0.025
detection of stimulus	GO:0051606	156	0.025
regulation of cellular amide metabolic process	GO:0034248	39	0.025
regulation of cellular amino acid metabolic process	GO:0006521	0	0.025
mrna processing	GO:0006397	104	0.025
regulation of organelle organization	GO:0033043	196	0.025
dna damage checkpoint	GO:0000077	78	0.025
ion transport	GO:0006811	145	0.025
cellular component assembly involved in morphogenesis	GO:0010927	151	0.025
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.025
organonitrogen compound metabolic process	GO:1901564	318	0.025
positive regulation of protein localization to nucleus	GO:1900182	21	0.024
response to alkaloid	GO:0043279	26	0.024
positive regulation of protein modification process	GO:0031401	58	0.024
mapk cascade	GO:0000165	107	0.024	Fly
response to fungus	GO:0009620	50	0.024
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.024
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria	GO:0002816	3	0.024
positive regulation of mapk cascade	GO:0043410	63	0.023	Fly
positive regulation of immune effector process	GO:0002699	28	0.023
negative regulation of mitotic cell cycle	GO:0045930	109	0.023
negative regulation of cell cycle process	GO:0010948	109	0.023
response to hydrogen peroxide	GO:0042542	11	0.023
cellular response to radiation	GO:0071478	52	0.023
extrinsic apoptotic signaling pathway	GO:0097191	1	0.023
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.023
asymmetric protein localization involved in cell fate determination	GO:0045167	9	0.022	Fly
larval midgut histolysis	GO:0035069	22	0.022
molting cycle chitin based cuticle	GO:0007591	56	0.022
carboxylic acid metabolic process	GO:0019752	92	0.022
regulation of response to oxidative stress	GO:1902882	4	0.022
multicellular organismal reproductive behavior	GO:0033057	110	0.022
gastrulation involving germ band extension	GO:0010004	36	0.022	Fly
positive regulation of phosphorus metabolic process	GO:0010562	139	0.022	Fly
response to heat	GO:0009408	63	0.022
regionalization	GO:0003002	416	0.022
regulation of ras protein signal transduction	GO:0046578	93	0.021
regulation of response to biotic stimulus	GO:0002831	63	0.021
open tracheal system development	GO:0007424	204	0.021
cellular lipid metabolic process	GO:0044255	83	0.021
negative regulation of cell death	GO:0060548	81	0.021
tissue migration	GO:0090130	155	0.021
salivary gland morphogenesis	GO:0007435	145	0.021	Fly
regulation of nucleocytoplasmic transport	GO:0046822	35	0.021
imaginal disc derived wing morphogenesis	GO:0007476	337	0.021
nephron epithelium development	GO:0072009	3	0.021
post embryonic appendage morphogenesis	GO:0035120	385	0.021
organ or tissue specific immune response	GO:0002251	10	0.021
positive regulation of intracellular transport	GO:0032388	42	0.021
cellular macromolecule localization	GO:0070727	220	0.021
cellular divalent inorganic cation homeostasis	GO:0072503	23	0.021
regulation of mrna metabolic process	GO:1903311	72	0.020
peripheral nervous system development	GO:0007422	52	0.020
gland morphogenesis	GO:0022612	145	0.020	Fly
regulation of antimicrobial peptide production	GO:0002784	44	0.020
response to oxidative stress	GO:0006979	86	0.020
eye antennal disc development	GO:0035214	60	0.020
cardiovascular system development	GO:0072358	82	0.020
jnk cascade	GO:0007254	50	0.020	Fly
blood circulation	GO:0008015	26	0.020
positive regulation of phosphorylation	GO:0042327	87	0.020	Fly
positive regulation of cell death	GO:0010942	69	0.020	Fly
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.020
muscle organ development	GO:0007517	127	0.020
metal ion transport	GO:0030001	74	0.020
cuticle pigmentation	GO:0048067	22	0.020
pigmentation	GO:0043473	75	0.020
regulation of cell size	GO:0008361	63	0.020
cellular cation homeostasis	GO:0030003	38	0.020
negative regulation of cellular component organization	GO:0051129	108	0.020
oxoacid metabolic process	GO:0043436	103	0.020
cellular response to biotic stimulus	GO:0071216	4	0.020
positive regulation of programmed cell death	GO:0043068	62	0.020	Fly
response to lipid	GO:0033993	38	0.020
response to organic cyclic compound	GO:0014070	89	0.020
cell activation	GO:0001775	9	0.020
cellular response to lipopolysaccharide	GO:0071222	3	0.020
positive regulation of phosphate metabolic process	GO:0045937	139	0.020	Fly
cellular nitrogen compound catabolic process	GO:0044270	165	0.020
protein targeting	GO:0006605	64	0.019
tube morphogenesis	GO:0035239	191	0.019	Fly
negative regulation of cell communication	GO:0010648	223	0.019
blastoderm segmentation	GO:0007350	159	0.019
organelle assembly	GO:0070925	198	0.019
respiratory system development	GO:0060541	213	0.019
vesicle fusion	GO:0006906	19	0.019
autophagic cell death	GO:0048102	83	0.019	Fly
germ line stem cell maintenance	GO:0030718	50	0.019
gland development	GO:0048732	191	0.019	Fly
response to metal ion	GO:0010038	23	0.019
skeletal muscle fiber development	GO:0048741	3	0.019
positive regulation of ras gtpase activity	GO:0032320	36	0.019
positive regulation of rna metabolic process	GO:0051254	271	0.019
regulation of protein import into nucleus	GO:0042306	28	0.019
macromolecular complex assembly	GO:0065003	256	0.019
kidney epithelium development	GO:0072073	3	0.019
antibacterial peptide biosynthetic process	GO:0002780	22	0.018
response to growth factor	GO:0070848	31	0.018
antimicrobial peptide biosynthetic process	GO:0002777	38	0.018
regulation of developmental pigmentation	GO:0048070	24	0.018
exocrine system development	GO:0035272	162	0.018	Fly
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.018
cellular metal ion homeostasis	GO:0006875	31	0.018
cell recognition	GO:0008037	102	0.018
guanosine containing compound catabolic process	GO:1901069	74	0.018
cellular response to external stimulus	GO:0071496	66	0.018
positive regulation of protein transport	GO:0051222	37	0.018
nephron tubule morphogenesis	GO:0072078	3	0.018
cell fate determination	GO:0001709	91	0.018	Fly
regulation of embryonic cell shape	GO:0016476	30	0.018
ion homeostasis	GO:0050801	55	0.018
tube development	GO:0035295	244	0.018	Fly
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.018
tissue morphogenesis	GO:0048729	297	0.018
cellular amino acid metabolic process	GO:0006520	61	0.018
regulation of cell division	GO:0051302	72	0.018
positive regulation of antimicrobial humoral response	GO:0002760	28	0.018
digestive tract morphogenesis	GO:0048546	127	0.017	Fly
response to light stimulus	GO:0009416	124	0.017
negative regulation of response to stimulus	GO:0048585	258	0.017
positive regulation of developmental growth	GO:0048639	62	0.017
macroautophagy	GO:0016236	42	0.017
negative regulation of multicellular organismal process	GO:0051241	142	0.017
organic hydroxy compound metabolic process	GO:1901615	83	0.017
amide biosynthetic process	GO:0043604	42	0.017
response to organonitrogen compound	GO:0010243	75	0.017
single organism membrane fusion	GO:0044801	42	0.017
rna processing	GO:0006396	147	0.017
developmental maturation	GO:0021700	172	0.017
ubiquitin dependent protein catabolic process	GO:0006511	78	0.017
neuroblast proliferation	GO:0007405	74	0.017
internal peptidyl lysine acetylation	GO:0018393	38	0.017
regulation of mrna splicing via spliceosome	GO:0048024	64	0.017
regulation of cellular localization	GO:0060341	136	0.017
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.016
cellular amine metabolic process	GO:0044106	12	0.016
peptidoglycan recognition protein signaling pathway	GO:0061057	16	0.016
single organism behavior	GO:0044708	391	0.016
sensory organ morphogenesis	GO:0090596	260	0.016
positive regulation of growth	GO:0045927	75	0.016
regulation of cell substrate adhesion	GO:0010810	2	0.016
internal protein amino acid acetylation	GO:0006475	38	0.016
negative regulation of signaling	GO:0023057	219	0.016
ion transmembrane transport	GO:0034220	122	0.016
actin filament organization	GO:0007015	126	0.016
protein ubiquitination	GO:0016567	70	0.016
alternative mrna splicing via spliceosome	GO:0000380	60	0.016
positive regulation of cell migration	GO:0030335	2	0.016
membrane depolarization	GO:0051899	4	0.016
single organism catabolic process	GO:0044712	228	0.016
cellular response to heat	GO:0034605	24	0.016
innate immune response activating signal transduction	GO:0002758	2	0.015
negative regulation of cell cycle phase transition	GO:1901988	103	0.015
nephron tubule development	GO:0072080	3	0.015
regulation of chromatin modification	GO:1903308	28	0.015
regulation of protein catabolic process	GO:0042176	55	0.015
determination of adult lifespan	GO:0008340	137	0.015
spindle organization	GO:0007051	253	0.015
morphogenesis of embryonic epithelium	GO:0016331	94	0.015
dorsal ventral pattern formation	GO:0009953	133	0.015
regulation of intracellular protein transport	GO:0033157	46	0.015
regulation of chromatin organization	GO:1902275	32	0.015
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.015
cell aging	GO:0007569	2	0.015
protein k48 linked ubiquitination	GO:0070936	3	0.015
rho protein signal transduction	GO:0007266	14	0.015
pattern recognition receptor signaling pathway	GO:0002221	2	0.015
modification dependent protein catabolic process	GO:0019941	78	0.015
segmentation	GO:0035282	207	0.015
regulation of proteolysis	GO:0030162	87	0.015
kidney morphogenesis	GO:0060993	3	0.015
salivary gland cell autophagic cell death	GO:0035071	83	0.015	Fly
muscle cell development	GO:0055001	50	0.015
immune system development	GO:0002520	57	0.015
establishment of protein localization to organelle	GO:0072594	62	0.015
regulation of antibacterial peptide biosynthetic process	GO:0002808	22	0.015
apical constriction	GO:0003383	18	0.015	Fly
epithelial cell migration	GO:0010631	148	0.014
positive regulation of multi organism process	GO:0043902	40	0.014
heart contraction	GO:0060047	26	0.014
stress activated protein kinase signaling cascade	GO:0031098	55	0.014
salivary gland development	GO:0007431	162	0.014	Fly
stem cell development	GO:0048864	79	0.014
positive regulation of calcium ion transport	GO:0051928	4	0.014
positive regulation of immune system process	GO:0002684	68	0.014
cation transmembrane transport	GO:0098655	88	0.014
membrane fusion	GO:0061025	42	0.014
pigment metabolic process	GO:0042440	84	0.014
positive regulation of apoptotic process	GO:0043065	47	0.014	Fly
lipid metabolic process	GO:0006629	121	0.014
regulation of mrna processing	GO:0050684	71	0.014
hemopoiesis	GO:0030097	46	0.014
myotube differentiation	GO:0014902	46	0.014
muscle tissue development	GO:0060537	30	0.014
developmental growth	GO:0048589	280	0.014
positive regulation of defense response to bacterium	GO:1900426	23	0.014
cell junction assembly	GO:0034329	42	0.014
positive regulation of cell motility	GO:2000147	3	0.014
cell growth	GO:0016049	108	0.013
calcium ion transport	GO:0006816	24	0.013
male gamete generation	GO:0048232	201	0.013
negative regulation of gene expression	GO:0010629	387	0.013
heterocycle catabolic process	GO:0046700	166	0.013
limb development	GO:0060173	1	0.013
positive regulation of secretion by cell	GO:1903532	20	0.013
regulation of cell morphogenesis	GO:0022604	163	0.013
stem cell differentiation	GO:0048863	117	0.013
mitotic cell cycle phase transition	GO:0044772	138	0.013
myoblast fusion	GO:0007520	43	0.013
circulatory system process	GO:0003013	37	0.013
leg disc development	GO:0035218	92	0.013
regulation of system process	GO:0044057	36	0.013
regulation of rna splicing	GO:0043484	69	0.013
enteroendocrine cell differentiation	GO:0035883	1	0.013

Traf6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.058
disease of cellular proliferation	DOID:14566	0.022
organ system cancer	DOID:0050686	0.014
cancer	DOID:162	0.014
musculoskeletal system disease	DOID:17	0.013
muscle tissue disease	DOID:66	0.013
muscular disease	DOID:0080000	0.013

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