IMP: Integrative Multi-species Prediction

Drosophila melanogaster

178 known processes

Atg1 (Dmel_CG10967)

Autophagy-specific gene 1

(Aliases: l(3)00305,DmATG1,anon-WO0118547.287,Unc-51,atg1,unc-51,DK-4,ATG1,CG10967,UNC 51-like,unc51,Dmel\CG10967)

FLYBASE: FBgn0260945
Entrez: 39454
UniProtKB: Q9VU14
UniProtKB: Q8MQJ7

Process Predictions
Disease Predictions

Atg1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
larval midgut histolysis	GO:0035069	22	1.000
autophagic vacuole assembly	GO:0000045	2	1.000
macroautophagy	GO:0016236	42	0.999
striated muscle cell differentiation	GO:0051146	90	0.993
axonogenesis	GO:0007409	290	0.993
autophagy	GO:0006914	108	0.989
regulation of autophagy	GO:0010506	62	0.988
cell death	GO:0008219	279	0.987
protein modification process	GO:0036211	438	0.984
axon development	GO:0061564	297	0.983
neurological system process	GO:0050877	358	0.982
phosphorylation	GO:0016310	294	0.979
larval midgut cell programmed cell death	GO:0035096	19	0.977
muscle cell differentiation	GO:0042692	103	0.975
apoptotic process	GO:0006915	159	0.974
multicellular organismal aging	GO:0010259	140	0.971
programmed cell death	GO:0012501	257	0.971
actomyosin structure organization	GO:0031032	56	0.964
single organism behavior	GO:0044708	391	0.963
death	GO:0016265	284	0.962
regulation of phosphorylation	GO:0042325	147	0.961
regulation of protein phosphorylation	GO:0001932	64	0.952
determination of adult lifespan	GO:0008340	137	0.952
immune system process	GO:0002376	347	0.950
response to extracellular stimulus	GO:0009991	116	0.948
cellular response to chemical stimulus	GO:0070887	199	0.944
neuromuscular junction development	GO:0007528	149	0.942
gland development	GO:0048732	191	0.942
synapse organization	GO:0050808	196	0.939
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.937
response to abiotic stimulus	GO:0009628	341	0.936
regulation of cell death	GO:0010941	173	0.935
cell motility	GO:0048870	251	0.933
negative regulation of cell communication	GO:0010648	223	0.921
actin cytoskeleton organization	GO:0030036	206	0.911
positive regulation of autophagy	GO:0010508	21	0.909
positive regulation of signaling	GO:0023056	243	0.905
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.895
synaptic growth at neuromuscular junction	GO:0051124	119	0.895
muscle structure development	GO:0061061	224	0.892
regulation of protein metabolic process	GO:0051246	256	0.891
chemotaxis	GO:0006935	249	0.891
intracellular signal transduction	GO:0035556	300	0.886
regulation of immune system process	GO:0002682	176	0.882
regulation of response to stress	GO:0080134	200	0.876
response to nutrient levels	GO:0031667	114	0.874
positive regulation of signal transduction	GO:0009967	223	0.873
positive regulation of cell communication	GO:0010647	250	0.872
immune response	GO:0006955	246	0.865
cellular protein modification process	GO:0006464	438	0.863
regulation of programmed cell death	GO:0043067	152	0.857
positive regulation of macromolecule metabolic process	GO:0010604	405	0.854
growth	GO:0040007	359	0.853
axon guidance	GO:0007411	233	0.850
cellular response to extracellular stimulus	GO:0031668	64	0.847
heart development	GO:0007507	82	0.843
catabolic process	GO:0009056	409	0.841
protein modification by small protein conjugation or removal	GO:0070647	106	0.841
lipid metabolic process	GO:0006629	121	0.837
protein phosphorylation	GO:0006468	169	0.834
regulation of defense response	GO:0031347	102	0.828
regulation of intracellular signal transduction	GO:1902531	236	0.826
positive regulation of macroautophagy	GO:0016239	8	0.821
regulation of macroautophagy	GO:0016241	15	0.813
cellular response to starvation	GO:0009267	61	0.809
histolysis	GO:0007559	102	0.806
regulation of cellular protein metabolic process	GO:0032268	243	0.805
regulation of cellular amino acid metabolic process	GO:0006521	0	0.805
organelle assembly	GO:0070925	198	0.798
response to starvation	GO:0042594	97	0.792
actin filament based process	GO:0030029	220	0.772
organelle fission	GO:0048285	340	0.771
developmental programmed cell death	GO:0010623	138	0.768
positive regulation of cell death	GO:0010942	69	0.760
response to external biotic stimulus	GO:0043207	293	0.759
forebrain development	GO:0030900	2	0.759
aging	GO:0007568	143	0.757
gland morphogenesis	GO:0022612	145	0.757
negative regulation of signaling	GO:0023057	219	0.755
positive regulation of response to stimulus	GO:0048584	323	0.754
negative regulation of response to stimulus	GO:0048585	258	0.745
regulation of immune response	GO:0050776	118	0.744
regulation of protein modification process	GO:0031399	112	0.742
cell fate specification	GO:0001708	71	0.739
mitochondrion organization	GO:0007005	65	0.734
synapse assembly	GO:0007416	143	0.716
larval development	GO:0002164	104	0.714
regulation of cell growth	GO:0001558	43	0.711
negative regulation of apoptotic process	GO:0043066	63	0.707
regulation of multicellular organismal development	GO:2000026	414	0.704
syncytium formation	GO:0006949	43	0.691
mapk cascade	GO:0000165	107	0.686
neuron projection guidance	GO:0097485	241	0.667
regulation of kinase activity	GO:0043549	53	0.664
salivary gland morphogenesis	GO:0007435	145	0.656
localization of cell	GO:0051674	257	0.655
cell migration	GO:0016477	238	0.654
regulation of protein kinase activity	GO:0045859	51	0.652
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	11	0.642
striated muscle cell development	GO:0055002	50	0.636
negative regulation of intracellular signal transduction	GO:1902532	57	0.633
defense response	GO:0006952	300	0.630
meiotic cell cycle	GO:0051321	171	0.620
regulation of catabolic process	GO:0009894	170	0.616
endocytosis	GO:0006897	310	0.616
regulation of response to nutrient levels	GO:0032107	18	0.616
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.610
apoptotic cell clearance	GO:0043277	14	0.604
chromatin organization	GO:0006325	207	0.604
muscle cell development	GO:0055001	50	0.604
defense response to other organism	GO:0098542	225	0.601
regulation of developmental growth	GO:0048638	174	0.585
response to biotic stimulus	GO:0009607	294	0.584
positive regulation of cellular protein metabolic process	GO:0032270	118	0.570
secretion	GO:0046903	109	0.568
hindbrain development	GO:0030902	2	0.566
ovarian follicle cell development	GO:0030707	248	0.566
protein localization to organelle	GO:0033365	82	0.564
regulation of synapse organization	GO:0050807	110	0.556
nuclear division	GO:0000280	332	0.555
negative regulation of programmed cell death	GO:0043069	72	0.554
negative regulation of growth	GO:0045926	84	0.549
negative regulation of cellular metabolic process	GO:0031324	382	0.545
regulation of anatomical structure size	GO:0090066	163	0.539
appendage development	GO:0048736	401	0.535
regulation of nurse cell apoptotic process	GO:0045477	9	0.526
regulation of phosphate metabolic process	GO:0019220	210	0.509
protein modification by small protein conjugation	GO:0032446	79	0.503
regulation of transferase activity	GO:0051338	58	0.501
apoptotic signaling pathway	GO:0097190	27	0.498
regulation of nervous system development	GO:0051960	248	0.493
regulation of response to wounding	GO:1903034	19	0.484
cellular catabolic process	GO:0044248	372	0.484
regulation of phosphorus metabolic process	GO:0051174	210	0.484
positive regulation of protein metabolic process	GO:0051247	128	0.483
regulation of catalytic activity	GO:0050790	185	0.481
cellular macromolecule localization	GO:0070727	220	0.471
hemopoiesis	GO:0030097	46	0.461
oxoacid metabolic process	GO:0043436	103	0.456
carboxylic acid metabolic process	GO:0019752	92	0.456
cell growth	GO:0016049	108	0.450
small molecule metabolic process	GO:0044281	305	0.445
regulation of cell proliferation	GO:0042127	163	0.442
positive regulation of catabolic process	GO:0009896	105	0.438
single organism catabolic process	GO:0044712	228	0.437
epithelial cell development	GO:0002064	274	0.429
taxis	GO:0042330	304	0.429
positive regulation of apoptotic process	GO:0043065	47	0.424
regulation of molecular function	GO:0065009	217	0.411
cardiovascular system development	GO:0072358	82	0.399
reproductive structure development	GO:0048608	74	0.399
regulation of cellular component biogenesis	GO:0044087	201	0.390
positive regulation of cellular component biogenesis	GO:0044089	80	0.386
cellular response to external stimulus	GO:0071496	66	0.376
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.374
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.374
regulation of cell differentiation	GO:0045595	302	0.373
hematopoietic or lymphoid organ development	GO:0048534	57	0.362
innate immune response	GO:0045087	144	0.360
tube development	GO:0035295	244	0.353
response to organic substance	GO:0010033	284	0.352
positive regulation of response to wounding	GO:1903036	15	0.350
response to wounding	GO:0009611	94	0.344
female meiotic division	GO:0007143	70	0.343
inositol lipid mediated signaling	GO:0048017	4	0.343
regulation of organelle organization	GO:0033043	196	0.342
regulation of cell cycle	GO:0051726	291	0.339
positive regulation of cell migration	GO:0030335	2	0.339
single organism membrane fusion	GO:0044801	42	0.338
positive regulation of phosphorylation	GO:0042327	87	0.335
macromolecule catabolic process	GO:0009057	161	0.335
regulation of cellular catabolic process	GO:0031329	157	0.332
tor signaling	GO:0031929	32	0.332
dendrite morphogenesis	GO:0048813	199	0.330
positive regulation of gene expression	GO:0010628	290	0.326
regulation of map kinase activity	GO:0043405	17	0.325
cellular ketone metabolic process	GO:0042180	24	0.325
regulation of multi organism process	GO:0043900	131	0.320
regulation of bmp signaling pathway	GO:0030510	23	0.319
regulation of growth	GO:0040008	233	0.317
positive regulation of programmed cell death	GO:0043068	62	0.311
positive regulation of molecular function	GO:0044093	136	0.311
tissue morphogenesis	GO:0048729	297	0.310
salivary gland development	GO:0007431	162	0.304
columnar cuboidal epithelial cell development	GO:0002066	249	0.303
gliogenesis	GO:0042063	80	0.301
negative regulation of cell size	GO:0045792	19	0.299
positive regulation of defense response	GO:0031349	59	0.297
lipid localization	GO:0010876	54	0.295
developmental growth	GO:0048589	280	0.293
exocrine system development	GO:0035272	162	0.287
reactive oxygen species metabolic process	GO:0072593	22	0.283
chromatin modification	GO:0016568	147	0.280
stem cell development	GO:0048864	79	0.276
activation of protein kinase activity	GO:0032147	12	0.275
regulation of behavior	GO:0050795	75	0.273
establishment of vesicle localization	GO:0051650	51	0.266
actin filament organization	GO:0007015	126	0.265
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	26	0.261
salivary gland cell autophagic cell death	GO:0035071	83	0.258
positive regulation of phosphate metabolic process	GO:0045937	139	0.257
cellular lipid metabolic process	GO:0044255	83	0.252
protein ubiquitination	GO:0016567	70	0.250
positive regulation of multicellular organismal process	GO:0051240	143	0.241
response to other organism	GO:0051707	293	0.240
regulation of response to external stimulus	GO:0032101	115	0.229
regulation of innate immune response	GO:0045088	71	0.224
regulation of mapk cascade	GO:0043408	92	0.223
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.221
protein catabolic process	GO:0030163	101	0.221
morphogenesis of an epithelium	GO:0002009	276	0.219
regulation of phosphatidylinositol 3 kinase activity	GO:0043551	2	0.218
organelle localization	GO:0051640	148	0.217
cellular amino acid metabolic process	GO:0006520	61	0.216
regulation of localization	GO:0032879	275	0.215
nucleocytoplasmic transport	GO:0006913	72	0.214
central nervous system development	GO:0007417	201	0.212
enteroendocrine cell differentiation	GO:0035883	1	0.211
tissue death	GO:0016271	102	0.209
regulation of cellular ketone metabolic process	GO:0010565	3	0.209
telencephalon development	GO:0021537	2	0.208
chemical homeostasis	GO:0048878	92	0.207
regulation of dendrite morphogenesis	GO:0048814	28	0.206
regulation of cellular amine metabolic process	GO:0033238	3	0.204
protein complex assembly	GO:0006461	200	0.204
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	16	0.200
regulation of secretion	GO:0051046	44	0.197
organic acid metabolic process	GO:0006082	103	0.196
dna metabolic process	GO:0006259	227	0.195
regulation of anatomical structure morphogenesis	GO:0022603	242	0.194
regulation of response to extracellular stimulus	GO:0032104	18	0.193
imaginal disc derived wing morphogenesis	GO:0007476	337	0.192
regulation of cellular response to stress	GO:0080135	89	0.188
respiratory system development	GO:0060541	213	0.186
regulation of apoptotic process	GO:0042981	130	0.185
tube morphogenesis	GO:0035239	191	0.184
immune system development	GO:0002520	57	0.182
response to radiation	GO:0009314	155	0.182
signal transduction by phosphorylation	GO:0023014	107	0.182
regulation of synapse structure and activity	GO:0050803	128	0.180
adult locomotory behavior	GO:0008344	76	0.179
cellularization	GO:0007349	90	0.176
germarium derived female germ line cyst formation	GO:0030727	42	0.173
covalent chromatin modification	GO:0016569	106	0.173
positive regulation of protein phosphorylation	GO:0001934	34	0.171
histone h4 acetylation	GO:0043967	13	0.170
vesicle mediated transport	GO:0016192	381	0.169
embryonic morphogenesis	GO:0048598	206	0.168
cellular amine metabolic process	GO:0044106	12	0.168
axon choice point recognition	GO:0016198	26	0.166
imaginal disc derived appendage development	GO:0048737	399	0.163
positive regulation of synapse assembly	GO:0051965	29	0.162
muscle fiber development	GO:0048747	12	0.162
single organism cellular localization	GO:1902580	180	0.161
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.161
regulation of protein serine threonine kinase activity	GO:0071900	25	0.161
positive regulation of developmental process	GO:0051094	143	0.161
actin filament bundle organization	GO:0061572	28	0.161
anatomical structure homeostasis	GO:0060249	97	0.159
cellular response to endogenous stimulus	GO:0071495	80	0.158
regulation of protein ubiquitination	GO:0031396	22	0.154
dendrite development	GO:0016358	204	0.153
cellular protein localization	GO:0034613	160	0.153
regulation of secretion by cell	GO:1903530	39	0.152
negative regulation of multicellular organismal process	GO:0051241	142	0.150
neuron death	GO:0070997	27	0.150
phagocytosis	GO:0006909	215	0.149
establishment of localization in cell	GO:0051649	402	0.148
positive regulation of cell size	GO:0045793	21	0.148
positive regulation of cellular component organization	GO:0051130	156	0.146
negative regulation of autophagy	GO:0010507	16	0.146
regulation of synapse assembly	GO:0051963	94	0.145
negative regulation of ras protein signal transduction	GO:0046580	13	0.144
axon midline choice point recognition	GO:0016199	26	0.144
regulation of peptidase activity	GO:0052547	39	0.144
regulation of pathway restricted smad protein phosphorylation	GO:0060393	1	0.143
melanin metabolic process	GO:0006582	47	0.142
cellular response to oxygen containing compound	GO:1901701	79	0.142
regulation of cell substrate adhesion	GO:0010810	2	0.141
negative regulation of cell cycle process	GO:0010948	109	0.140
open tracheal system development	GO:0007424	204	0.139
regulation of neuron differentiation	GO:0045664	103	0.138
cell cycle phase transition	GO:0044770	140	0.134
peptidyl amino acid modification	GO:0018193	105	0.133
epidermal cell differentiation	GO:0009913	51	0.129
mitotic cell cycle phase transition	GO:0044772	138	0.129
positive regulation of pathway restricted smad protein phosphorylation	GO:0010862	1	0.128
positive regulation of protein modification process	GO:0031401	58	0.128
positive regulation of intracellular signal transduction	GO:1902533	116	0.127
jnk cascade	GO:0007254	50	0.126
cell proliferation involved in imaginal disc derived wing morphogenesis	GO:0090255	2	0.126
meiotic nuclear division	GO:0007126	151	0.124
regulation of cell size	GO:0008361	63	0.124
interspecies interaction between organisms	GO:0044419	16	0.124
heart contraction	GO:0060047	26	0.123
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.122
vacuole organization	GO:0007033	8	0.120
negative regulation of cell death	GO:0060548	81	0.120
protein targeting to nucleus	GO:0044744	51	0.119
regulation of cell motility	GO:2000145	23	0.119
cell junction assembly	GO:0034329	42	0.118
cellular component assembly involved in morphogenesis	GO:0010927	151	0.117
phosphatidylinositol mediated signaling	GO:0048015	4	0.116
multicellular organism growth	GO:0035264	46	0.116
positive regulation of mapk cascade	GO:0043410	63	0.115
biological adhesion	GO:0022610	138	0.115
regulation of neurogenesis	GO:0050767	158	0.114
negative regulation of signal transduction	GO:0009968	206	0.113
multicellular organismal homeostasis	GO:0048871	41	0.111
negative regulation of cell differentiation	GO:0045596	143	0.110
regulation of wound healing	GO:0061041	13	0.110
cellular response to organic substance	GO:0071310	132	0.109
positive regulation of protein serine threonine kinase activity	GO:0071902	15	0.109
protein maturation	GO:0051604	71	0.107
response to oxygen containing compound	GO:1901700	200	0.107
blood circulation	GO:0008015	26	0.106
response to light stimulus	GO:0009416	124	0.106
stress activated mapk cascade	GO:0051403	52	0.106
locomotory behavior	GO:0007626	176	0.105
myoblast fusion	GO:0007520	43	0.105
muscle system process	GO:0003012	21	0.104
regulation of stress activated mapk cascade	GO:0032872	41	0.101
sex differentiation	GO:0007548	81	0.101
regulation of transport	GO:0051049	181	0.100
defense response to bacterium	GO:0042742	178	0.099
positive regulation of phosphorus metabolic process	GO:0010562	139	0.099
positive regulation of kinase activity	GO:0033674	25	0.099
regulation of actin polymerization or depolymerization	GO:0008064	27	0.097
regulation of cellular localization	GO:0060341	136	0.097
cell adhesion	GO:0007155	136	0.096
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.094
negative regulation of transferase activity	GO:0051348	18	0.094
negative regulation of small gtpase mediated signal transduction	GO:0051058	13	0.091
extrinsic apoptotic signaling pathway	GO:0097191	1	0.090
cell type specific apoptotic process	GO:0097285	38	0.090
protein complex biogenesis	GO:0070271	201	0.090
peptidyl lysine modification	GO:0018205	57	0.089
actin filament bundle assembly	GO:0051017	26	0.089
embryo development ending in birth or egg hatching	GO:0009792	152	0.087
organic substance transport	GO:0071702	257	0.087
regulation of cell development	GO:0060284	215	0.086
pigment metabolic process	GO:0042440	84	0.086
positive regulation of rna biosynthetic process	GO:1902680	266	0.083
epithelial cell differentiation	GO:0030855	322	0.083
immune effector process	GO:0002252	98	0.083
skin development	GO:0043588	65	0.081
heart process	GO:0003015	37	0.081
neuromuscular synaptic transmission	GO:0007274	67	0.081
sensory perception	GO:0007600	196	0.079
salivary gland histolysis	GO:0035070	88	0.079
extracellular structure organization	GO:0043062	46	0.078
positive regulation of response to extracellular stimulus	GO:0032106	8	0.075
response to uv	GO:0009411	24	0.074
glycerolipid metabolic process	GO:0046486	34	0.074
proteolysis	GO:0006508	192	0.074
epithelial tube morphogenesis	GO:0060562	88	0.073
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.071
negative regulation of cellular component organization	GO:0051129	108	0.071
macromolecular complex assembly	GO:0065003	256	0.070
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.070
positive regulation of transcription dna templated	GO:0045893	266	0.070
single organism cell adhesion	GO:0098602	47	0.070
nuclear import	GO:0051170	51	0.070
positive regulation of growth	GO:0045927	75	0.069
eggshell formation	GO:0030703	105	0.069
aromatic compound catabolic process	GO:0019439	166	0.069
positive regulation of lipid metabolic process	GO:0045834	4	0.069
secretion by cell	GO:0032940	101	0.068
reproductive system development	GO:0061458	74	0.068
regulation of cell division	GO:0051302	72	0.068
regulation of mitosis	GO:0007088	56	0.067
protein localization to nucleus	GO:0034504	55	0.067
negative regulation of phosphatidylinositol 3 kinase signaling	GO:0014067	4	0.066
positive regulation of catalytic activity	GO:0043085	118	0.066
activation of mapk activity	GO:0000187	9	0.066
positive regulation of cell motility	GO:2000147	3	0.066
phagocytosis engulfment	GO:0006911	11	0.065
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.065
dorsal ventral axis specification	GO:0009950	66	0.065
defense response to virus	GO:0051607	23	0.065
wnt signaling pathway	GO:0016055	98	0.064
meiotic cell cycle process	GO:1903046	132	0.064
glycerophospholipid metabolic process	GO:0006650	23	0.062
regionalization	GO:0003002	416	0.060
positive regulation of jnk cascade	GO:0046330	16	0.058
regulation of cytoskeleton organization	GO:0051493	89	0.058
striated muscle myosin thick filament assembly	GO:0071688	3	0.058
negative regulation of protein metabolic process	GO:0051248	85	0.058
cell elongation involved in imaginal disc derived wing morphogenesis	GO:0090254	5	0.057
appendage morphogenesis	GO:0035107	397	0.057
regulation of system process	GO:0044057	36	0.057
circulatory system development	GO:0072359	82	0.056
positive regulation of nervous system development	GO:0051962	69	0.056
positive regulation of cell proliferation	GO:0008284	47	0.056
single organism intracellular transport	GO:1902582	207	0.056
brain development	GO:0007420	120	0.056
regulation of gene expression epigenetic	GO:0040029	128	0.056
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.056
regulation of mitotic cell cycle	GO:0007346	190	0.055
positive regulation of immune response	GO:0050778	63	0.055
regulation of jnk cascade	GO:0046328	40	0.055
insulin receptor signaling pathway	GO:0008286	25	0.055
metal ion homeostasis	GO:0055065	44	0.054
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.054
unidimensional cell growth	GO:0009826	15	0.054
regulation of cell migration	GO:0030334	22	0.054
negative regulation of developmental process	GO:0051093	201	0.054
positive regulation of response to nutrient levels	GO:0032109	8	0.053
organic substance catabolic process	GO:1901575	308	0.053
negative regulation of protein phosphorylation	GO:0001933	17	0.053
protein localization	GO:0008104	284	0.053
cognition	GO:0050890	141	0.053
cellular protein complex assembly	GO:0043623	71	0.052
collateral sprouting	GO:0048668	3	0.051
regulation of exocytosis	GO:0017157	6	0.051
homeostatic process	GO:0042592	199	0.051
glial cell migration	GO:0008347	31	0.051
protein transport	GO:0015031	155	0.051
negative regulation of cell development	GO:0010721	62	0.051
regulation of hemocyte differentiation	GO:0045610	22	0.051
intracellular transport	GO:0046907	228	0.051
positive regulation of protein catabolic process	GO:0045732	34	0.051
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.050
notch signaling pathway	GO:0007219	120	0.050
transcription from rna polymerase ii promoter	GO:0006366	368	0.050
dorsal ventral pattern formation	GO:0009953	133	0.050
cellular homeostasis	GO:0019725	80	0.050
cellular response to nutrient levels	GO:0031669	62	0.050
response to virus	GO:0009615	28	0.050
regulation of phosphatidylinositol 3 kinase signaling	GO:0014066	4	0.049
positive regulation of protein kinase activity	GO:0045860	25	0.049
development of primary sexual characteristics	GO:0045137	50	0.049
positive regulation of jun kinase activity	GO:0043507	4	0.049
meiotic chromosome segregation	GO:0045132	59	0.048
maintenance of location	GO:0051235	73	0.048
spiracle morphogenesis open tracheal system	GO:0035277	22	0.048
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.048
epithelial cell migration open tracheal system	GO:0007427	32	0.047
mitotic nuclear division	GO:0007067	213	0.047
trunk segmentation	GO:0035290	8	0.047
single organism carbohydrate metabolic process	GO:0044723	72	0.047
cellular response to peptide	GO:1901653	28	0.047
oocyte differentiation	GO:0009994	145	0.047
peptidyl tyrosine phosphorylation	GO:0018108	24	0.047
adherens junction organization	GO:0034332	27	0.047
activation of jun kinase activity	GO:0007257	3	0.047
regulation of cell matrix adhesion	GO:0001952	1	0.047
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.046
feeding behavior	GO:0007631	50	0.046
regulation of apoptotic signaling pathway	GO:2001233	10	0.046
hemocyte migration	GO:0035099	19	0.046
cellular cation homeostasis	GO:0030003	38	0.046
regulation of epithelial cell proliferation	GO:0050678	4	0.046
regulation of cell cell adhesion	GO:0022407	21	0.045
negative regulation of erbb signaling pathway	GO:1901185	29	0.045
circulatory system process	GO:0003013	37	0.045
regulation of hydrolase activity	GO:0051336	97	0.044
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.044
cell competition in a multicellular organism	GO:0035212	10	0.044
negative regulation of phosphorus metabolic process	GO:0010563	45	0.044
regulation of erbb signaling pathway	GO:1901184	42	0.044
positive regulation of stress activated mapk cascade	GO:0032874	17	0.044
head involution	GO:0008258	35	0.044
nuclear transport	GO:0051169	72	0.043
cytoplasmic transport	GO:0016482	130	0.043
motor neuron axon guidance	GO:0008045	58	0.042
response to fungus	GO:0009620	50	0.042
vesicle localization	GO:0051648	55	0.042
positive regulation of organelle organization	GO:0010638	65	0.042
response to nitrogen compound	GO:1901698	90	0.042
regulation of cellular component size	GO:0032535	98	0.041
regulation of lipid kinase activity	GO:0043550	2	0.041
cellular response to insulin stimulus	GO:0032869	28	0.041
rho protein signal transduction	GO:0007266	14	0.041
protein autophosphorylation	GO:0046777	15	0.041
regulation of response to biotic stimulus	GO:0002831	63	0.041
cell matrix adhesion	GO:0007160	6	0.041
autophagic cell death	GO:0048102	83	0.041
regulation of tube size	GO:0035150	46	0.041
establishment of planar polarity	GO:0001736	87	0.040
humoral immune response	GO:0006959	117	0.040
positive regulation of cell adhesion	GO:0045785	10	0.040
negative regulation of cell proliferation	GO:0008285	69	0.040
regulation of proteolysis	GO:0030162	87	0.039
single organism nuclear import	GO:1902593	51	0.039
proteasomal protein catabolic process	GO:0010498	59	0.039
cellular protein catabolic process	GO:0044257	83	0.039

Atg1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
large intestine cancer	DOID:5672	0.183
gastrointestinal system cancer	DOID:3119	0.183
intestinal cancer	DOID:10155	0.183
cancer	DOID:162	0.183
disease of cellular proliferation	DOID:14566	0.183
organ system cancer	DOID:0050686	0.183
colorectal cancer	DOID:9256	0.183
disease of anatomical entity	DOID:7	0.041
nervous system disease	DOID:863	0.041

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