Drosophila melanogaster

192 known processes

Ice (Dmel_CG7788)

CG7788 gene product from transcript CG7788-RA

(Aliases: caspase 3,crice,ice,drIce,ICE,drice,Drice,DRICE,DrIce,CG7788,DrICE,Dmel\CG7788,drICE)

Ice biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
activation of cysteine type endopeptidase activityGO:0097202170.652
Fly
regulation of endopeptidase activityGO:0052548360.575
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919160.509
Fly
positive regulation of apoptotic signaling pathwayGO:200123540.472
response to ionizing radiationGO:0010212320.467
regulation of retinal cell programmed cell deathGO:0046668180.449
defense response to virusGO:0051607230.439
Fly
positive regulation of proteolysisGO:0045862520.437
response to starvationGO:0042594970.394
Fly
autophagyGO:00069141080.332
Fly
regulation of cellular protein metabolic processGO:00322682430.299
positive regulation of endopeptidase activityGO:0010950260.287
gland morphogenesisGO:00226121450.264
gland developmentGO:00487321910.257
spermatid differentiationGO:00485151140.256
spermatid developmentGO:0007286980.253
Fly
regulation of response to external stimulusGO:00321011150.245
Fly
exocrine system developmentGO:00352721620.237
tissue deathGO:00162711020.233
regulation of cell differentiationGO:00455953020.227
cell cycle checkpointGO:0000075950.204
salivary gland morphogenesisGO:00074351450.199
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281250.198
organic hydroxy compound metabolic processGO:1901615830.196
Fly
positive regulation of cysteine type endopeptidase activityGO:2001056240.194
regulation of compound eye retinal cell programmed cell deathGO:0046669180.190
cellular amino acid metabolic processGO:0006520610.186
programmed cell deathGO:00125012570.186
cell deathGO:00082192790.185
response to organophosphorusGO:004668320.182
histolysisGO:00075591020.176
protein heterooligomerizationGO:005129140.175
Fly
positive regulation of autophagyGO:0010508210.174
Fly
developmental programmed cell deathGO:00106231380.171
peripheral nervous system developmentGO:0007422520.171
Fly
ovarian follicle cell developmentGO:00307072480.158
apoptotic processGO:00069151590.154
epithelial cell developmentGO:00020642740.153
regulation of protein metabolic processGO:00512462560.151
regulation of programmed cell deathGO:00430671520.148
regulation of cysteine type endopeptidase activityGO:2000116270.148
regulation of proteolysisGO:0030162870.144
response to abiotic stimulusGO:00096283410.143
regulation of cell deathGO:00109411730.142
compound eye developmentGO:00487493070.142
appendage morphogenesisGO:00351073970.135
sensory organ morphogenesisGO:00905962600.135
melanization defense responseGO:0035006450.134
Fly
neuron remodelingGO:0016322290.134
regulation of multicellular organismal developmentGO:20000264140.133
compound eye morphogenesisGO:00017452490.131
response to radiationGO:00093141550.131
retinal cell programmed cell deathGO:0046666250.130
dendrite developmentGO:00163582040.125
Fly
cellular response to extracellular stimulusGO:0031668640.125
Fly
regulation of response to stressGO:00801342000.124
Fly
regulation of organ morphogenesisGO:2000027780.120
regulation of anatomical structure morphogenesisGO:00226032420.119
spermatogenesisGO:00072832000.117
columnar cuboidal epithelial cell developmentGO:00020662490.114
catabolic processGO:00090564090.112
Fly
proteolysisGO:00065081920.111
carboxylic acid metabolic processGO:0019752920.111
imaginal disc derived appendage morphogenesisGO:00351143950.110
compound eye retinal cell programmed cell deathGO:0046667230.108
positive regulation of rna metabolic processGO:00512542710.107
oxoacid metabolic processGO:00434361030.106
growthGO:00400073590.105
regulation of anatomical structure sizeGO:00900661630.103
eye morphogenesisGO:00485922600.098
small molecule metabolic processGO:00442813050.098
organelle assemblyGO:00709251980.097
organic substance catabolic processGO:19015753080.096
deathGO:00162652840.096
regulation of transcription from rna polymerase ii promoterGO:00063573780.096
determination of adult lifespanGO:00083401370.095
Fly
columnar cuboidal epithelial cell differentiationGO:00020652560.095
cellular ketone metabolic processGO:0042180240.093
asymmetric cell divisionGO:0008356370.092
sperm individualizationGO:0007291480.090
Fly
protein complex assemblyGO:00064612000.088
Fly
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280230.088
positive regulation of multicellular organismal processGO:00512401430.087
regulation of cell cycleGO:00517262910.087
membrane protein proteolysisGO:003361960.086
regulation of peptidase activityGO:0052547390.086
male gamete generationGO:00482322010.084
appendage developmentGO:00487364010.083
heart developmentGO:0007507820.083
ovarian follicle cell migrationGO:00072971210.082
immune effector processGO:0002252980.081
Fly
epithelial cell differentiationGO:00308553220.080
regulation of response to nutrient levelsGO:0032107180.079
Fly
eye developmentGO:00016543230.079
regulation of cellular catabolic processGO:00313291570.078
Fly
autophagic cell deathGO:0048102830.078
Fly
positive regulation of peptidase activityGO:0010952290.076
ameboidal type cell migrationGO:00016671510.076
cell cell signaling involved in cell fate commitmentGO:00451682100.075
biosynthetic process of antibacterial peptides active against gram negative bacteriaGO:0002812140.074
Fly
positive regulation of programmed cell deathGO:0043068620.073
organic acid metabolic processGO:00060821030.073
imaginal disc derived appendage developmentGO:00487373990.073
protein transportGO:00150311550.071
positive regulation of cell deathGO:0010942690.071
organic substance transportGO:00717022570.069
central nervous system developmentGO:00074172010.069
Fly
negative regulation of cell differentiationGO:00455961430.067
actin filament organizationGO:00070151260.067
single organism catabolic processGO:00447122280.067
Fly
phenol containing compound metabolic processGO:0018958570.066
Fly
cellular catabolic processGO:00442483720.064
Fly
protein modification processGO:00362114380.064
regulation of cellular amino acid metabolic processGO:000652100.063
positive regulation of macromolecule metabolic processGO:00106044050.063
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.062
response to extracellular stimulusGO:00099911160.062
Fly
endocytosisGO:00068973100.062
developmental growthGO:00485892800.062
wnt signaling pathwayGO:0016055980.061
regulation of defense response to bacteriumGO:1900424300.061
Fly
synaptic transmissionGO:00072682880.059
Fly
epithelium migrationGO:00901321480.058
embryonic morphogenesisGO:00485982060.058
Fly
forebrain developmentGO:003090020.057
immune responseGO:00069552460.057
Fly
regulation of cell cycle processGO:00105641810.057
cellular response to dna damage stimulusGO:00069742230.056
execution phase of apoptosisGO:009719470.056
regulation of synapse structure and activityGO:00508031280.055
response to organic substanceGO:00100332840.055
imaginal disc derived wing morphogenesisGO:00074763370.054
tissue migrationGO:00901301550.054
response to lipopolysaccharideGO:003249640.054
negative regulation of multicellular organismal processGO:00512411420.052
positive regulation of protein metabolic processGO:00512471280.052
positive regulation of antimicrobial peptide productionGO:0002225280.052
Fly
pigment metabolic processGO:0042440840.050
Fly
apoptotic signaling pathwayGO:0097190270.050
immune system processGO:00023763470.050
Fly
regulation of synapse organizationGO:00508071100.049
regulation of response to biotic stimulusGO:0002831630.049
Fly
organelle fissionGO:00482853400.048
regulation of cellular ketone metabolic processGO:001056530.048
positive regulation of immune effector processGO:0002699280.047
Fly
digestive tract developmentGO:00485651490.047
organonitrogen compound metabolic processGO:19015643180.046
Fly
synaptic growth at neuromuscular junctionGO:00511241190.045
protein complex biogenesisGO:00702712010.044
Fly
protein catabolic processGO:00301631010.044
positive regulation of cellular protein metabolic processGO:00322701180.044
macromolecule catabolic processGO:00090571610.044
dendrite morphogenesisGO:00488131990.044
Fly
protein maturationGO:0051604710.044
nurse cell apoptotic processGO:0045476170.043
mitotic cytokinesisGO:0000281500.043
regulation of cell cycle phase transitionGO:19019871300.043
negative regulation of signalingGO:00230572190.043
Fly
response to bacteriumGO:00096171980.043
Fly
protein ubiquitinationGO:0016567700.042
positive regulation of transcription dna templatedGO:00458932660.042
positive regulation of signalingGO:00230562430.041
regulation of cellular component biogenesisGO:00440872010.041
salivary gland developmentGO:00074311620.040
cellular protein modification processGO:00064644380.040
protein modification by small protein conjugation or removalGO:00706471060.040
humoral immune responseGO:00069591170.040
Fly
regulation of apoptotic processGO:00429811300.040
multicellular organismal agingGO:00102591400.039
Fly
mitotic cell cycle phase transitionGO:00447721380.039
positive regulation of nucleic acid templated transcriptionGO:19035082660.038
epithelial structure maintenanceGO:0010669170.038
intracellular signal transductionGO:00355563000.038
apoptotic process involved in developmentGO:1902742200.037
regulation of humoral immune responseGO:0002920510.037
Fly
cellular macromolecule catabolic processGO:00442651360.037
cell cycle phase transitionGO:00447701400.037
positive regulation of response to stimulusGO:00485843230.036
regulation of growthGO:00400082330.036
regulation of catabolic processGO:00098941700.036
Fly
dna damage checkpointGO:0000077780.036
vesicle mediated transportGO:00161923810.036
positive regulation of apoptotic processGO:0043065470.035
cellular homeostasisGO:0019725800.035
brain developmentGO:00074201200.035
cell cycle arrestGO:000705040.035
response to virusGO:0009615280.035
Fly
regulation of cell developmentGO:00602842150.034
regulation of response to extracellular stimulusGO:0032104180.034
Fly
positive regulation of protein transportGO:0051222370.034
positive regulation of rna biosynthetic processGO:19026802660.034
spindle organizationGO:00070512530.034
positive regulation of production of molecular mediator of immune responseGO:0002702280.033
Fly
negative regulation of cellular component organizationGO:00511291080.032
protein geranylgeranylationGO:001834430.032
positive regulation of cellular component organizationGO:00511301560.032
cell divisionGO:00513012480.032
establishment or maintenance of cell polarityGO:00071631670.032
cell growthGO:00160491080.031
organonitrogen compound biosynthetic processGO:19015661170.031
Fly
extrinsic apoptotic signaling pathwayGO:009719110.031
positive regulation of response to external stimulusGO:0032103440.031
Fly
respiratory system developmentGO:00605412130.031
regulation of synapse assemblyGO:0051963940.031
secondary metabolic processGO:0019748750.030
Fly
salivary gland cell autophagic cell deathGO:0035071830.030
Fly
cellular nitrogen compound catabolic processGO:00442701650.030
protein processingGO:0016485680.030
positive regulation of gene expressionGO:00106282900.030
tube morphogenesisGO:00352391910.029
aromatic compound catabolic processGO:00194391660.029
macromolecular complex assemblyGO:00650032560.029
Fly
negative regulation of cell cycleGO:00457861160.029
regulation of synaptic growth at neuromuscular junctionGO:0008582890.029
maintenance of epithelial integrity open tracheal systemGO:0035160120.029
notch signaling pathwayGO:00072191200.028
protein localizationGO:00081042840.028
negative regulation of programmed cell deathGO:0043069720.028
Fly
positive regulation of antibacterial peptide biosynthetic processGO:0006963200.027
Fly
muscle structure developmentGO:00610612240.027
morphogenesis of an epitheliumGO:00020092760.026
response to external biotic stimulusGO:00432072930.026
Fly
regulation of cell morphogenesisGO:00226041630.026
establishment of localization in cellGO:00516494020.026
cellular component disassemblyGO:0022411460.026
proteasomal protein catabolic processGO:0010498590.026
mitotic spindle organizationGO:00070522200.026
salivary gland histolysisGO:0035070880.026
positive regulation of cell cycle processGO:0090068280.026
post embryonic appendage morphogenesisGO:00351203850.025
positive regulation of hydrolase activityGO:0051345780.025
cellular response to abiotic stimulusGO:0071214580.025
protein k48 linked ubiquitinationGO:007093630.025
lateral inhibitionGO:00463312060.025
positive regulation of nitrogen compound metabolic processGO:00511733540.025
defense responseGO:00069523000.025
Fly
positive regulation of cell cycleGO:0045787430.025
regulation of immune responseGO:00507761180.025
Fly
open tracheal system developmentGO:00074242040.025
positive regulation of transportGO:0051050920.025
chorion containing eggshell formationGO:00073041050.024
negative regulation of cell cycle processGO:00109481090.024
regulation of synaptic transmissionGO:0050804690.024
Fly
establishment of protein localizationGO:00451841630.024
regulation of peptidyl lysine acetylationGO:200075670.024
homeostatic processGO:00425921990.024
cytokinesisGO:0000910900.024
regulation of cell proliferationGO:00421271630.024
Fly
peripheral nervous system neuron differentiationGO:004893480.024
Fly
negative regulation of developmental processGO:00510932010.024
regulation of tube sizeGO:0035150460.023
negative regulation of cell cycle phase transitionGO:19019881030.023
transcription from rna polymerase ii promoterGO:00063663680.023
nuclear divisionGO:00002803320.023
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.022
positive regulation of biosynthetic processGO:00098913160.022
regulation of developmental growthGO:00486381740.022
regulation of cytoskeleton organizationGO:0051493890.022
epithelial cell migrationGO:00106311480.022
cardiovascular system developmentGO:0072358820.022
regulation of mitotic cell cycleGO:00073461900.022
negative regulation of cell deathGO:0060548810.022
Fly
body morphogenesisGO:001017120.021
positive regulation of antimicrobial humoral responseGO:0002760280.021
Fly
synapse assemblyGO:00074161430.021
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.021
cellular response to radiationGO:0071478520.021
dna integrity checkpointGO:0031570810.021
stem cell differentiationGO:00488631170.021
peptide metabolic processGO:0006518800.021
Fly
organelle localizationGO:00516401480.021
cellular amine metabolic processGO:0044106120.020
negative regulation of organelle organizationGO:0010639560.020
positive regulation of humoral immune responseGO:0002922280.020
Fly
regulation of cellular amine metabolic processGO:003323830.020
defense response to other organismGO:00985422250.020
Fly
cellular response to chemical stimulusGO:00708871990.020
amine metabolic processGO:0009308120.020
response to nutrient levelsGO:00316671140.020
Fly
phagocytosisGO:00069092150.019
regulation of organelle organizationGO:00330431960.019
positive regulation of signal transductionGO:00099672230.019
establishment of tissue polarityGO:0007164870.019
mitotic nuclear divisionGO:00070672130.019
response to ethanolGO:0045471590.019
positive regulation of cell differentiationGO:0045597640.019
triglyceride homeostasisGO:0070328180.019
regulation of intracellular signal transductionGO:19025312360.019
regulation of mitotic cell cycle phase transitionGO:19019901300.019
nucleobase containing compound catabolic processGO:00346551650.019
g protein coupled receptor signaling pathwayGO:00071861360.019
negative regulation of nucleobase containing compound metabolic processGO:00459342610.019
mitotic cell cycle checkpointGO:0007093880.019
cell motilityGO:00488702510.019
cellular macromolecule localizationGO:00707272200.019
regulation of production of molecular mediator of immune responseGO:0002700440.018
Fly
cytoskeleton dependent cytokinesisGO:0061640810.018
developmental maturationGO:00217001720.018
antibacterial humoral responseGO:0019731440.018
Fly
cellularizationGO:0007349900.018
Fly
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.018
regulation of wnt signaling pathwayGO:0030111680.018
response to other organismGO:00517072930.018
Fly
negative regulation of rna biosynthetic processGO:19026792400.018
eggshell formationGO:00307031050.018
regulation of apoptotic signaling pathwayGO:2001233100.018
protein localization to nucleusGO:0034504550.017
regulation of autophagyGO:0010506620.017
Fly
regulation of protein transportGO:0051223570.017
maintenance of locationGO:0051235730.017
tube developmentGO:00352952440.017
wing disc morphogenesisGO:00074723440.017
amide biosynthetic processGO:0043604420.017
Fly
cellular component assembly involved in morphogenesisGO:00109271510.017
antimicrobial humoral responseGO:0019730990.017
Fly
intracellular protein transportGO:00068861040.016
regulation of cellular localizationGO:00603411360.016
regulation of intracellular protein transportGO:0033157460.016
positive regulation of compound eye retinal cell programmed cell deathGO:004667290.016
regulation of innate immune responseGO:0045088710.016
Fly
negative regulation of biosynthetic processGO:00098902770.016
regulation of transportGO:00510491810.016
digestive tract morphogenesisGO:00485461270.016
localization of cellGO:00516742570.016
photoreceptor cell differentiationGO:00465301700.016
regulation of catalytic activityGO:00507901850.016
peptide biosynthetic processGO:0043043420.016
Fly
regulation of protein ubiquitinationGO:0031396220.016
peptidoglycan recognition protein signaling pathwayGO:0061057160.016
Fly
posttranscriptional regulation of gene expressionGO:00106081450.015
regulation of rna polymerase ii transcriptional preinitiation complex assemblyGO:004589810.015
negative regulation of mitotic cell cycle phase transitionGO:19019911030.015
anatomical structure homeostasisGO:0060249970.015
positive regulation of catabolic processGO:00098961050.015
Fly
regulation of notch signaling pathwayGO:00085931000.015
regulation of protein localizationGO:0032880760.015
cytoplasmic transportGO:00164821300.015
striated muscle cell differentiationGO:0051146900.015
organonitrogen compound catabolic processGO:19015651280.015
kidney developmentGO:000182230.015
response to alcoholGO:0097305950.015
muscle cell differentiationGO:00426921030.015
cellular protein localizationGO:00346131600.015
establishment of planar polarityGO:0001736870.014
positive regulation of cell growthGO:0030307190.014
cellular amide metabolic processGO:0043603800.014
Fly
regulation of chromatin organizationGO:1902275320.014
regulation of protein modification processGO:00313991120.014
cell proliferationGO:00082832990.014
Fly
limb developmentGO:006017310.014
mitochondrion organizationGO:0007005650.014
tissue morphogenesisGO:00487292970.014
mitotic dna integrity checkpointGO:0044774750.014
border follicle cell migrationGO:00072981130.014
positive regulation of cellular component biogenesisGO:0044089800.014
protein modification by small protein conjugationGO:0032446790.014
zymogen activationGO:0031638200.014
Fly
positive regulation of cell communicationGO:00106472500.014
cell migrationGO:00164772380.013
intrinsic apoptotic signaling pathwayGO:0097193160.013
positive regulation of intracellular signal transductionGO:19025331160.013
antibacterial peptide productionGO:0002778220.013
Fly
regulation of i kappab kinase nf kappab signalingGO:004312220.013
positive regulation of retinal cell programmed cell deathGO:004667090.013
single organism biosynthetic processGO:00447112060.013
regulation of cell shapeGO:00083601130.013
regulation of histone modificationGO:0031056200.013
single organism behaviorGO:00447083910.013
camera type eye developmentGO:004301040.013
actin filament based processGO:00300292200.013
chromosome segregationGO:00070591570.013
organic cyclic compound catabolic processGO:19013611680.013
regulation of chromosome organizationGO:0033044640.013
neurological system processGO:00508773580.013
regulation of protein acetylationGO:190198370.013
protein acetylationGO:0006473390.013
positive regulation of molecular functionGO:00440931360.012
cellular protein complex assemblyGO:0043623710.012
taxisGO:00423303040.012
cognitionGO:00508901410.012
positive regulation of antibacterial peptide productionGO:0002803200.012
Fly
defense response to gram negative bacteriumGO:0050829940.012
Fly
regulation of nervous system developmentGO:00519602480.012
negative regulation of cell developmentGO:0010721620.012
regulation of protein catabolic processGO:0042176550.012
response to hypoxiaGO:0001666530.012
regulation of antimicrobial peptide biosynthetic processGO:0002805380.012
Fly
antibacterial peptide biosynthetic processGO:0002780220.012
Fly
protein targetingGO:0006605640.012
regulation of macroautophagyGO:0016241150.012
Fly
regulation of protein stabilityGO:0031647430.012
prenylationGO:009735430.012
intracellular transportGO:00469072280.012
cellular macromolecular complex assemblyGO:00346221530.012
actin cytoskeleton organizationGO:00300362060.012
renal system developmentGO:0072001720.012
negative regulation of signal transductionGO:00099682060.012
olfactory behaviorGO:0042048970.012
regulation of establishment of protein localizationGO:0070201610.012
cell adhesionGO:00071551360.011
synapse organizationGO:00508081960.011
negative regulation of immune system processGO:0002683500.011
antimicrobial peptide biosynthetic processGO:0002777380.011
Fly
single organism cellular localizationGO:19025801800.011
regulation of immune effector processGO:0002697520.011
Fly
regulation of protein modification by small protein conjugation or removalGO:1903320250.011
response to nitrogen compoundGO:1901698900.011
regulation of proteasomal protein catabolic processGO:0061136390.011
positive regulation of catalytic activityGO:00430851180.011
positive regulation of protein localization to nucleusGO:1900182210.011
peripheral nervous system neuron developmentGO:004893580.011
Fly
regulation of molecular functionGO:00650092170.011
nucleotide metabolic processGO:00091171610.011
positive regulation of cell developmentGO:0010720610.011
regulation of antimicrobial peptide productionGO:0002784440.011
Fly
negative regulation of nervous system developmentGO:0051961920.010
regulation of defense responseGO:00313471020.010
Fly
cell cell junction assemblyGO:0007043380.010
cell cell adhesion via plasma membrane adhesion moleculesGO:0098742260.010
negative regulation of cell communicationGO:00106482230.010
Fly
regulation of tube architecture open tracheal systemGO:0035152680.010

Ice disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.177
musculoskeletal system diseaseDOID:1700.029