Drosophila melanogaster

141 known processes

slik (Dmel_CG4527)

Sterile20-like kinase

(Aliases: slk,Dmel\CG4527,PLKK1,Plkk/Slik,Slk,CG4527,Slik,Slik1,DPlkk1,Plkk1,SLK,dPlkk/Slik)

slik biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
growthGO:00400073590.714
compound eye photoreceptor developmentGO:0042051780.648
compound eye photoreceptor cell differentiationGO:00017511400.630
tor signalingGO:0031929320.596
imaginal disc derived wing morphogenesisGO:00074763370.454
regulation of growthGO:00400082330.448
eye photoreceptor cell developmentGO:0042462810.396
imaginal disc derived appendage developmentGO:00487373990.392
photoreceptor cell differentiationGO:00465301700.331
compound eye developmentGO:00487493070.306
imaginal disc derived appendage morphogenesisGO:00351143950.254
homeostatic processGO:00425921990.235
regulation of tor signalingGO:0032006210.225
regulation of cell sizeGO:0008361630.219
imaginal disc derived leg morphogenesisGO:0007480800.216
wing disc morphogenesisGO:00074723440.212
eye photoreceptor cell differentiationGO:00017541450.188
eye developmentGO:00016543230.185
post embryonic appendage morphogenesisGO:00351203850.184
multi organism behaviorGO:00517051750.183
regulation of developmental growthGO:00486381740.169
agingGO:00075681430.168
programmed cell deathGO:00125012570.153
Rat
developmental pigmentationGO:0048066680.144
endosome transport via multivesicular body sorting pathwayGO:0032509120.142
ras protein signal transductionGO:0007265880.137
negative regulation of cell communicationGO:00106482230.127
positive regulation of tor signalingGO:0032008130.125
regulation of notch signaling pathwayGO:00085931000.125
long chain fatty acid biosynthetic processGO:004275910.118
apoptotic processGO:00069151590.117
Rat
appendage developmentGO:00487364010.114
leg disc morphogenesisGO:0007478800.111
photoreceptor cell developmentGO:0042461960.110
cell motilityGO:00488702510.103
Human Mouse
positive regulation of developmental growthGO:0048639620.102
sensory organ morphogenesisGO:00905962600.101
regulation of cell differentiationGO:00455953020.100
protein complex assemblyGO:00064612000.093
regulation of epidermal growth factor receptor signaling pathwayGO:0042058420.087
columnar cuboidal epithelial cell developmentGO:00020662490.087
response to oxygen containing compoundGO:19017002000.086
eye morphogenesisGO:00485922600.084
positive regulation of phosphate metabolic processGO:00459371390.082
nuclear divisionGO:00002803320.076
regulation of phosphorylationGO:00423251470.075
ocellus pigmentationGO:0033060190.075
negative regulation of signal transductionGO:00099682060.073
chemical homeostasisGO:0048878920.073
cholesterol homeostasisGO:004263230.071
guanosine containing compound metabolic processGO:1901068740.070
negative regulation of signalingGO:00230572190.069
cell deathGO:00082192790.069
Rat
positive regulation of multicellular organism growthGO:0040018210.068
appendage morphogenesisGO:00351073970.067
regulation of ras protein signal transductionGO:0046578930.066
regulation of mitotic cell cycleGO:00073461900.065
positive regulation of growthGO:0045927750.065
regulation of multi organism processGO:00439001310.064
compound eye morphogenesisGO:00017452490.063
regulation of phosphatase activityGO:001092130.061
positive regulation of protein metabolic processGO:00512471280.061
positive regulation of phosphorus metabolic processGO:00105621390.061
carboxylic acid metabolic processGO:0019752920.061
developmental programmed cell deathGO:00106231380.060
epithelial cell developmentGO:00020642740.060
cardiovascular system developmentGO:0072358820.060
protein complex biogenesisGO:00702712010.059
rho protein signal transductionGO:0007266140.059
vesicle mediated transportGO:00161923810.059
regulation of protein transportGO:0051223570.058
cellular macromolecular complex assemblyGO:00346221530.057
regulation of intracellular signal transductionGO:19025312360.057
small gtpase mediated signal transductionGO:0007264880.057
developmental growthGO:00485892800.056
embryonic development via the syncytial blastodermGO:00017001480.055
erbb signaling pathwayGO:0038127580.055
regulation of cellular component sizeGO:0032535980.054
regulation of organ growthGO:0046620420.054
positive regulation of cell communicationGO:00106472500.053
regulation of multicellular organism growthGO:0040014400.052
actin cytoskeleton organizationGO:00300362060.051
small molecule metabolic processGO:00442813050.051
lipid homeostasisGO:0055088330.050
positive regulation of signal transductionGO:00099672230.050
dna packagingGO:0006323910.050
regulation of localizationGO:00328792750.050
positive regulation of phosphorylationGO:0042327870.049
rhabdomere developmentGO:0042052380.049
stress activated protein kinase signaling cascadeGO:0031098550.048
regulation of imaginal disc growthGO:0045570260.048
positive regulation of macromolecule metabolic processGO:00106044050.047
organic acid metabolic processGO:00060821030.047
ribonucleoside triphosphate catabolic processGO:00092031080.046
negative regulation of intracellular signal transductionGO:1902532570.046
determination of adult lifespanGO:00083401370.045
oxoacid metabolic processGO:00434361030.045
tissue homeostasisGO:0001894360.045
cellular response to peptideGO:1901653280.045
regulation of rho protein signal transductionGO:0035023200.044
regulation of multicellular organismal developmentGO:20000264140.043
organic substance catabolic processGO:19015753080.042
imaginal disc derived wing margin morphogenesisGO:0008587410.042
membrane biogenesisGO:004409180.042
positive regulation of nucleotide metabolic processGO:0045981550.042
regulation of anatomical structure sizeGO:00900661630.040
immune response regulating signaling pathwayGO:000276420.040
transcription from rna polymerase ii promoterGO:00063663680.039
intracellular protein transportGO:00068861040.039
organic substance transportGO:00717022570.038
organic cyclic compound catabolic processGO:19013611680.038
regulation of erbb signaling pathwayGO:1901184420.038
regulation of molecular functionGO:00650092170.038
regulation of anatomical structure morphogenesisGO:00226032420.038
regulation of ras gtpase activityGO:0032318380.037
positive regulation of purine nucleotide catabolic processGO:0033123460.036
actin filament organizationGO:00070151260.035
negative regulation of small gtpase mediated signal transductionGO:0051058130.035
lateral inhibitionGO:00463312060.034
positive regulation of response to stimulusGO:00485843230.034
notch signaling pathwayGO:00072191200.033
protein phosphorylationGO:00064681690.033
embryonic morphogenesisGO:00485982060.032
response to extracellular stimulusGO:00099911160.032
cell migrationGO:00164772380.032
Human Mouse
nucleoside phosphate catabolic processGO:19012921100.032
nucleoside catabolic processGO:00091641120.032
regulation of gtpase activityGO:0043087440.032
regulation of epithelial cell proliferationGO:005067840.031
endocytosisGO:00068973100.031
triglyceride homeostasisGO:0070328180.030
positive regulation of signalingGO:00230562430.030
positive regulation of developmental processGO:00510941430.030
reproductive behaviorGO:00190981220.030
cellular homeostasisGO:0019725800.029
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.029
positive regulation of rna metabolic processGO:00512542710.029
cellular response to organonitrogen compoundGO:0071417360.029
positive regulation of intracellular signal transductionGO:19025331160.028
regulation of nucleotide catabolic processGO:0030811480.028
eye pigmentationGO:0048069430.028
multicellular organism growthGO:0035264460.028
positive regulation of kinase activityGO:0033674250.028
chorion containing eggshell formationGO:00073041050.027
positive regulation of jun kinase activityGO:004350740.027
rubidium ion transportGO:003582610.027
deathGO:00162652840.027
Rat
negative regulation of developmental processGO:00510932010.027
positive regulation of nucleic acid templated transcriptionGO:19035082660.026
regulation of catalytic activityGO:00507901850.026
activation of jun kinase activityGO:000725730.026
immune response activating signal transductionGO:000275720.026
membrane organizationGO:00610241120.026
response to sterolGO:0036314340.026
single organism intracellular transportGO:19025822070.026
positive regulation of protein modification processGO:0031401580.026
jak stat cascadeGO:0007259490.025
regulation of protein kinase activityGO:0045859510.025
post golgi vesicle mediated transportGO:0006892110.025
positive regulation of mapk cascadeGO:0043410630.025
regulation of small gtpase mediated signal transductionGO:0051056930.025
enzyme linked receptor protein signaling pathwayGO:00071671790.025
positive regulation of mitotic cell cycleGO:0045931340.025
intracellular transportGO:00469072280.025
negative regulation of growthGO:0045926840.024
rac protein signal transductionGO:001660130.024
positive regulation of cellular response to insulin stimulusGO:190007840.024
protein localizationGO:00081042840.023
taxisGO:00423303040.023
histolysisGO:00075591020.023
establishment of localization in cellGO:00516494020.023
negative regulation of response to stimulusGO:00485852580.023
negative regulation of tor signalingGO:003200750.022
actin filament based processGO:00300292200.022
salivary gland developmentGO:00074311620.022
insulin receptor signaling pathwayGO:0008286250.022
regulation of synapse organizationGO:00508071100.022
activation of mapk activityGO:000018790.022
positive regulation of cellular biosynthetic processGO:00313283160.022
regulation of kinase activityGO:0043549530.022
negative regulation of insulin receptor signaling pathwayGO:0046627110.022
phagocytosisGO:00069092150.022
ribonucleoside metabolic processGO:00091191270.022
positive regulation of nucleotide catabolic processGO:0030813460.021
embryo development ending in birth or egg hatchingGO:00097921520.021
cellular response to oxygen containing compoundGO:1901701790.021
cellular protein complex assemblyGO:0043623710.021
immune responseGO:00069552460.021
lipid metabolic processGO:00066291210.021
ocellus pigment metabolic processGO:0046158190.021
membrane buddingGO:000690040.021
response to organonitrogen compoundGO:0010243750.021
aromatic compound catabolic processGO:00194391660.021
purine nucleoside triphosphate metabolic processGO:00091441190.021
larval developmentGO:00021641040.020
Worm
negative regulation of phosphorylationGO:0042326350.020
regulation of nucleoside metabolic processGO:0009118500.020
cytokinesisGO:0000910900.020
steroid metabolic processGO:0008202200.020
regulation of cell deathGO:00109411730.020
Rat
epithelial cell differentiationGO:00308553220.020
salivary gland histolysisGO:0035070880.020
nucleotide catabolic processGO:00091661090.020
golgi vesicle transportGO:0048193270.019
regulation of cell developmentGO:00602842150.019
regulation of transportGO:00510491810.019
cellular protein modification processGO:00064644380.019
regulation of establishment of protein localizationGO:0070201610.019
regulation of protein localizationGO:0032880760.019
proteolysis involved in cellular protein catabolic processGO:0051603830.019
phosphorylationGO:00163102940.019
hormone metabolic processGO:0042445330.019
regulation of cell growthGO:0001558430.019
regionalizationGO:00030024160.018
ion homeostasisGO:0050801550.018
regulation of hippo signalingGO:0035330140.018
localization of cellGO:00516742570.018
Human Mouse
signal transduction by phosphorylationGO:00230141070.018
cell proliferationGO:00082832990.018
mitotic cell cycle phase transitionGO:00447721380.017
regulation of transferase activityGO:0051338580.017
cellular response to insulin stimulusGO:0032869280.017
regulation of cellular localizationGO:00603411360.017
cytoplasmic transportGO:00164821300.017
positive regulation of multicellular organismal processGO:00512401430.017
cellular protein localizationGO:00346131600.017
negative regulation of catalytic activityGO:0043086420.017
regulation of rho gtpase activityGO:0032319200.017
ovarian follicle cell developmentGO:00307072480.017
developmental cell growthGO:0048588520.017
multicellular organismal homeostasisGO:0048871410.017
regulation of vesicle mediated transportGO:0060627590.016
ribonucleoside triphosphate metabolic processGO:00091991190.016
salivary gland cell autophagic cell deathGO:0035071830.016
response to nitrogen compoundGO:1901698900.016
catabolic processGO:00090564090.016
single organism catabolic processGO:00447122280.016
molting cycleGO:0042303560.016
glycosyl compound catabolic processGO:19016581120.016
regulation of phosphate metabolic processGO:00192202100.016
organonitrogen compound metabolic processGO:19015643180.016
dorsal ventral axis specificationGO:0009950660.016
secondary metabolite biosynthetic processGO:0044550240.016
regulation of cellular response to insulin stimulusGO:1900076170.016
protein transportGO:00150311550.015
regulation of protein metabolic processGO:00512462560.015
nucleoside metabolic processGO:00091161270.015
regulation of stress activated mapk cascadeGO:0032872410.015
macromolecular complex assemblyGO:00650032560.015
purine containing compound catabolic processGO:00725231120.015
negative regulation of organ growthGO:0046621150.015
cellular carbohydrate metabolic processGO:0044262220.015
regulation of transcription from rna polymerase ii promoterGO:00063573780.015
anatomical structure homeostasisGO:0060249970.015
negative regulation of nitrogen compound metabolic processGO:00511722650.015
epidermal growth factor receptor signaling pathwayGO:0007173580.015
organ growthGO:0035265560.015
regulation of hormone levelsGO:0010817400.014
regulation of gtp catabolic processGO:0033124440.014
instar larval developmentGO:0002168550.014
tissue deathGO:00162711020.014
establishment of organelle localizationGO:00516561220.014
positive regulation of gtpase activityGO:0043547430.014
chemotaxisGO:00069352490.014
metal ion homeostasisGO:0055065440.014
positive regulation of nucleobase containing compound metabolic processGO:00459353320.014
purine ribonucleoside metabolic processGO:00461281270.014
long chain fatty acid metabolic processGO:000167630.014
positive regulation of cellular component organizationGO:00511301560.014
Rat
imaginal disc derived wing vein morphogenesisGO:0008586440.013
cell growthGO:00160491080.013
cellular ketone metabolic processGO:0042180240.013
establishment of protein localizationGO:00451841630.013
sex differentiationGO:0007548810.013
hormone biosynthetic processGO:0042446200.013
intracellular signal transductionGO:00355563000.013
erk1 and erk2 cascadeGO:0070371390.013
locomotory behaviorGO:00076261760.013
single organism cellular localizationGO:19025801800.013
regulation of protein modification processGO:00313991120.013
cation transportGO:00068121100.013
negative regulation of phosphatidylinositol 3 kinase signalingGO:001406740.013
negative regulation of epidermal growth factor receptor signaling pathwayGO:0042059290.013
organophosphate catabolic processGO:00464341120.013
pigment metabolic process involved in developmental pigmentationGO:0043324330.013
regulation of apoptotic processGO:00429811300.013
Rat
regulation of cellular catabolic processGO:00313291570.013
negative regulation of protein metabolic processGO:0051248850.013
response to abiotic stimulusGO:00096283410.012
dna metabolic processGO:00062592270.012
regulation of cellular protein metabolic processGO:00322682430.012
monocarboxylic acid transportGO:001571830.012
positive regulation of lipid biosynthetic processGO:004688930.012
positive regulation of cellular protein metabolic processGO:00322701180.012
regulation of phospholipase activityGO:001051720.012
cellular response to hypoxiaGO:0071456280.012
regulation of reproductive processGO:2000241540.012
vacuolar transportGO:0007034130.012
cellular response to decreased oxygen levelsGO:0036294300.012
stress activated mapk cascadeGO:0051403520.012
single organism biosynthetic processGO:00447112060.012
positive regulation of biosynthetic processGO:00098913160.012
protein modification processGO:00362114380.012
cell cycle g2 m phase transitionGO:0044839220.012
regulation of neuron differentiationGO:00456641030.012
receptor clusteringGO:004311330.012
oocyte differentiationGO:00099941450.012
positive regulation of cell sizeGO:0045793210.012
purine nucleoside catabolic processGO:00061521120.012
adult behaviorGO:00305341370.012
negative regulation of notch signaling pathwayGO:0045746410.012
regulation of wnt signaling pathwayGO:0030111680.012
negative regulation of cytoskeleton organizationGO:0051494300.011
multicellular organismal agingGO:00102591400.011
regulation of establishment of protein localization to plasma membraneGO:009000370.011
response to alcoholGO:0097305950.011
response to endogenous stimulusGO:00097191190.011
carbohydrate derivative catabolic processGO:19011361180.011
regulation of insulin receptor signaling pathwayGO:0046626170.011
purine ribonucleoside triphosphate metabolic processGO:00092051190.011
negative regulation of epithelial cell proliferationGO:005068040.011
regulation of intracellular protein transportGO:0033157460.011
response to peptideGO:1901652290.011
immune system processGO:00023763470.011
Human Mouse
nucleobase containing compound catabolic processGO:00346551650.011
positive regulation of peptidyl tyrosine phosphorylationGO:005073140.011
regulation of neurogenesisGO:00507671580.011
response to unfolded proteinGO:000698690.011
compound eye photoreceptor fate commitmentGO:0001752360.011
inter male aggressive behaviorGO:0002121600.011
regulation of stress activated protein kinase signaling cascadeGO:0070302420.011
response to organic substanceGO:00100332840.011
Rat
regulation of phosphorus metabolic processGO:00511742100.010
positive regulation of bindingGO:005109940.010
response to nutrient levelsGO:00316671140.010
eggshell formationGO:00307031050.010
imaginal disc growthGO:0007446370.010
blastoderm segmentationGO:00073501590.010
regulation of intracellular transportGO:0032386640.010
cellular response to nitrogen compoundGO:1901699510.010
pigmentationGO:0043473750.010
hippo signalingGO:0035329200.010
regulation of cell cycleGO:00517262910.010
regulation of jnk cascadeGO:0046328400.010
positive regulation of cell growthGO:0030307190.010
regulation of rac protein signal transductionGO:003502030.010
peptidyl threonine modificationGO:001821030.010

slik disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
organ system cancerDOID:005068600.030
disease of cellular proliferationDOID:1456600.030
cancerDOID:16200.030