Drosophila melanogaster

43 known processes

Gclc (Dmel_CG2259)

Glutamate-cysteine ligase catalytic subunit

(Aliases: Dmel\CG2259,DmGCLC,Gcsh,GCL,CG2259,GCLc,Gcs,DmGCSh,2259,DmGCS,GCSh)

Gclc biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
organophosphate metabolic processGO:00196371950.151
multicellular organismal agingGO:00102591400.127
single organism catabolic processGO:00447122280.109
determination of adult lifespanGO:00083401370.105
small molecule metabolic processGO:00442813050.105
agingGO:00075681430.097
response to organic substanceGO:00100332840.094
regulation of intracellular signal transductionGO:19025312360.079
response to oxygen containing compoundGO:19017002000.077
organonitrogen compound metabolic processGO:19015643180.076
intracellular signal transductionGO:00355563000.074
behavioral response to ethanolGO:0048149490.073
response to alcoholGO:0097305950.071
purine ribonucleoside triphosphate metabolic processGO:00092051190.070
regulation of transcription from rna polymerase ii promoterGO:00063573780.070
metal ion transportGO:0030001740.069
catabolic processGO:00090564090.068
cation transportGO:00068121100.063
organonitrogen compound catabolic processGO:19015651280.062
purine nucleotide catabolic processGO:00061951090.061
phosphorylationGO:00163102940.061
organic substance catabolic processGO:19015753080.059
ribonucleoside metabolic processGO:00091191270.058
cellular amino acid metabolic processGO:0006520610.057
adult behaviorGO:00305341370.057
regulation of phosphate metabolic processGO:00192202100.056
response to lipopolysaccharideGO:003249640.052
regulation of phosphorus metabolic processGO:00511742100.051
response to mercury ionGO:004668930.051
anion homeostasisGO:005508130.051
cellular lipid metabolic processGO:0044255830.050
ribose phosphate metabolic processGO:00196931450.050
response to abiotic stimulusGO:00096283410.049
ribonucleotide metabolic processGO:00092591450.049
purine ribonucleoside metabolic processGO:00461281270.048
purine containing compound metabolic processGO:00725211550.047
negative regulation of cellular metabolic processGO:00313243820.046
carbohydrate derivative catabolic processGO:19011361180.046
response to oxidative stressGO:0006979860.046
steroid catabolic processGO:000670610.046
purine ribonucleotide catabolic processGO:00091541090.045
nucleotide metabolic processGO:00091171610.044
glycosyl compound metabolic processGO:19016571270.044
carbohydrate derivative metabolic processGO:19011352170.043
ion transportGO:00068111450.043
negative regulation of cell communicationGO:00106482230.043
vesicle mediated transportGO:00161923810.043
nucleoside catabolic processGO:00091641120.043
positive regulation of response to stimulusGO:00485843230.043
ribonucleoside triphosphate catabolic processGO:00092031080.043
cellular catabolic processGO:00442483720.042
nucleobase containing compound catabolic processGO:00346551650.042
lipid metabolic processGO:00066291210.041
purine nucleoside metabolic processGO:00422781270.041
nucleobase containing small molecule metabolic processGO:00550861740.040
single organism behaviorGO:00447083910.040
insecticide metabolic processGO:001714320.040
ribonucleoside triphosphate metabolic processGO:00091991190.040
negative regulation of response to stimulusGO:00485852580.039
regulation of phosphorylationGO:00423251470.039
ras protein signal transductionGO:0007265880.038
response to insulinGO:0032868290.038
signal transduction by phosphorylationGO:00230141070.038
activation of innate immune responseGO:000221840.037
defense responseGO:00069523000.037
wing disc morphogenesisGO:00074723440.037
transcription from rna polymerase ii promoterGO:00063663680.037
immune response regulating signaling pathwayGO:000276420.037
response to organonitrogen compoundGO:0010243750.036
regulation of catalytic activityGO:00507901850.036
peptide metabolic processGO:0006518800.035
regionalizationGO:00030024160.035
lipopolysaccharide mediated signaling pathwayGO:003166310.035
organic acid metabolic processGO:00060821030.035
establishment of localization in cellGO:00516494020.035
purine ribonucleoside triphosphate catabolic processGO:00092071080.035
regulation of cellular catabolic processGO:00313291570.035
jnk cascadeGO:0007254500.035
aromatic compound catabolic processGO:00194391660.035
nucleoside triphosphate catabolic processGO:00091431080.035
regulation of ras protein signal transductionGO:0046578930.034
purine nucleoside triphosphate catabolic processGO:00091461080.034
organic cyclic compound catabolic processGO:19013611680.033
purine ribonucleotide metabolic processGO:00091501450.033
response to bacteriumGO:00096171980.033
purine nucleoside catabolic processGO:00061521120.033
purine nucleoside triphosphate metabolic processGO:00091441190.033
regulation of catabolic processGO:00098941700.032
ion transmembrane transportGO:00342201220.032
deathGO:00162652840.032
sulfur compound biosynthetic processGO:0044272160.032
transmembrane transportGO:00550851390.032
purine containing compound catabolic processGO:00725231120.032
endocytosisGO:00068973100.032
cellular nitrogen compound catabolic processGO:00442701650.032
positive regulation of signalingGO:00230562430.032
small gtpase mediated signal transductionGO:0007264880.032
positive regulation of nitrogen compound metabolic processGO:00511733540.032
fat soluble vitamin metabolic processGO:000677510.031
nucleoside triphosphate metabolic processGO:00091411200.031
positive regulation of signal transductionGO:00099672230.031
response to other organismGO:00517072930.030
regulation of molecular functionGO:00650092170.030
positive regulation of jun kinase activityGO:004350740.030
response to nitrogen compoundGO:1901698900.030
nucleoside phosphate metabolic processGO:00067531620.030
nucleoside metabolic processGO:00091161270.029
phagocytosisGO:00069092150.029
polyol biosynthetic processGO:004617330.029
response to external biotic stimulusGO:00432072930.029
regulation of cellular ketone metabolic processGO:001056530.029
appendage developmentGO:00487364010.029
cellular response to molecule of bacterial originGO:007121930.028
positive regulation of catalytic activityGO:00430851180.028
nucleotide catabolic processGO:00091661090.028
purine ribonucleoside catabolic processGO:00461301120.028
appendage morphogenesisGO:00351073970.028
hormone catabolic processGO:004244730.028
organic substance transportGO:00717022570.028
response to ethanolGO:0045471590.027
cell deathGO:00082192790.027
neurological system processGO:00508773580.027
macromolecule catabolic processGO:00090571610.027
positive regulation of cell communicationGO:00106472500.027
post embryonic appendage morphogenesisGO:00351203850.027
regulation of mapk cascadeGO:0043408920.027
immune response activating signal transductionGO:000275720.027
cellular response to peptide hormone stimulusGO:0071375280.027
cellular response to chemical stimulusGO:00708871990.027
positive regulation of molecular functionGO:00440931360.027
regulation of transportGO:00510491810.027
response to biotic stimulusGO:00096072940.027
secondary metabolic processGO:0019748750.027
negative regulation of signal transductionGO:00099682060.026
stress activated mapk cascadeGO:0051403520.026
negative regulation of nitrogen compound metabolic processGO:00511722650.026
carboxylic acid metabolic processGO:0019752920.026
oxoacid metabolic processGO:00434361030.026
regulation of cellular component biogenesisGO:00440872010.026
heterocycle catabolic processGO:00467001660.026
negative regulation of nucleic acid templated transcriptionGO:19035072400.025
cellular amine metabolic processGO:0044106120.025
positive regulation of nucleobase containing compound metabolic processGO:00459353320.025
positive regulation of phosphate metabolic processGO:00459371390.025
xenobiotic catabolic processGO:004217810.025
vitamin biosynthetic processGO:000911010.025
immune responseGO:00069552460.025
regulation of immune system processGO:00026821760.024
cellular protein modification processGO:00064644380.024
defense response to bacteriumGO:00427421780.024
growthGO:00400073590.024
organophosphate catabolic processGO:00464341120.024
defense response to other organismGO:00985422250.024
cellular response to organic substanceGO:00713101320.024
actin cytoskeleton organizationGO:00300362060.024
gtp catabolic processGO:0006184720.024
homeostatic processGO:00425921990.023
imaginal disc derived wing morphogenesisGO:00074763370.023
positive regulation of phosphorus metabolic processGO:00105621390.023
telencephalon developmentGO:002153720.023
nucleoside phosphate catabolic processGO:19012921100.023
mapk cascadeGO:00001651070.023
purine nucleotide metabolic processGO:00061631460.023
regulation of cellular response to stressGO:0080135890.023
single organism biosynthetic processGO:00447112060.023
ribonucleoside catabolic processGO:00424541120.023
enzyme linked receptor protein signaling pathwayGO:00071671790.023
response to glucoseGO:000974920.023
organonitrogen compound biosynthetic processGO:19015661170.023
regulation of cell cycleGO:00517262910.022
response to nutrient levelsGO:00316671140.022
response to hexoseGO:000974630.022
divalent inorganic cation transportGO:0072511300.022
toxin metabolic processGO:000940420.022
transition metal ion homeostasisGO:0055076170.022
chemical homeostasisGO:0048878920.022
regulation of cellular localizationGO:00603411360.022
glycosyl compound catabolic processGO:19016581120.022
regulation of small gtpase mediated signal transductionGO:0051056930.022
positive regulation of biosynthetic processGO:00098913160.022
cellular ketone metabolic processGO:0042180240.022
regulation of localizationGO:00328792750.022
cellular response to lipopolysaccharideGO:007122230.022
imaginal disc derived appendage developmentGO:00487373990.021
cation transmembrane transportGO:0098655880.021
negative regulation of gene expressionGO:00106293870.021
cellular response to biotic stimulusGO:007121640.021
ribonucleotide catabolic processGO:00092611090.021
protein modification processGO:00362114380.021
programmed cell deathGO:00125012570.021
purine ribonucleoside monophosphate metabolic processGO:0009167500.021
fat soluble vitamin biosynthetic processGO:004236210.021
phosphatidic acid metabolic processGO:004647310.021
regulation of developmental growthGO:00486381740.021
negative regulation of signalingGO:00230572190.021
amine metabolic processGO:0009308120.020
response to endogenous stimulusGO:00097191190.020
regulation of jnk cascadeGO:0046328400.020
lauric acid metabolic processGO:004825210.020
positive regulation of macromolecule metabolic processGO:00106044050.020
apoptotic processGO:00069151590.020
amide biosynthetic processGO:0043604420.020
regulation of response to stressGO:00801342000.019
negative regulation of biosynthetic processGO:00098902770.019
regulation of organelle organizationGO:00330431960.019
cellular response to oxygen containing compoundGO:1901701790.019
glutathione metabolic processGO:0006749370.019
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.019
actin filament based processGO:00300292200.019
positive regulation of intracellular signal transductionGO:19025331160.019
response to starvationGO:0042594970.019
cellular homeostasisGO:0019725800.019
regulation of epithelial cell proliferationGO:005067840.019
single organism carbohydrate metabolic processGO:0044723720.019
regulation of apoptotic processGO:00429811300.019
pattern recognition receptor signaling pathwayGO:000222120.018
leg disc developmentGO:0035218920.018
body morphogenesisGO:001017120.018
ameboidal type cell migrationGO:00016671510.018
regulation of anatomical structure sizeGO:00900661630.018
positive regulation of purine nucleotide metabolic processGO:1900544550.018
regulation of programmed cell deathGO:00430671520.018
response to radiationGO:00093141550.018
regulation of nucleotide catabolic processGO:0030811480.018
monocarboxylic acid transportGO:001571830.018
lipid biosynthetic processGO:0008610460.017
cellular modified amino acid metabolic processGO:0006575450.017
gtp metabolic processGO:0046039720.017
guanosine containing compound catabolic processGO:1901069740.017
camera type eye developmentGO:004301040.017
retina development in camera type eyeGO:006004140.017
regulation of immune responseGO:00507761180.017
carbohydrate metabolic processGO:0005975820.017
localization of cellGO:00516742570.017
sensory perception of smellGO:0007608800.017
atp metabolic processGO:0046034490.017
positive regulation of rna metabolic processGO:00512542710.017
immune system processGO:00023763470.017
regulation of insulin receptor signaling pathwayGO:0046626170.017
innate immune response activating signal transductionGO:000275820.017
regulation of cell differentiationGO:00455953020.017
metal ion homeostasisGO:0055065440.017
oxidation reduction processGO:00551141230.017
response to monosaccharideGO:003428440.017
forebrain developmentGO:003090020.017
positive regulation of gtpase activityGO:0043547430.017
positive regulation of purine nucleotide catabolic processGO:0033123460.017
cellular response to insulin stimulusGO:0032869280.016
positive regulation of catabolic processGO:00098961050.016
organelle assemblyGO:00709251980.016
response to heatGO:0009408630.016
regulation of hydrolase activityGO:0051336970.016
ribonucleoside monophosphate metabolic processGO:0009161510.016
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.016
cellular macromolecule localizationGO:00707272200.016
nucleoside monophosphate metabolic processGO:0009123520.016
immune effector processGO:0002252980.016
organophosphate biosynthetic processGO:0090407460.016
regulation of cellular response to insulin stimulusGO:1900076170.016
positive regulation of cellular catabolic processGO:0031331950.015
compound eye morphogenesisGO:00017452490.015
negative regulation of rna metabolic processGO:00512532510.015
imaginal disc derived leg morphogenesisGO:0007480800.015
stress activated protein kinase signaling cascadeGO:0031098550.015
multi organism behaviorGO:00517051750.015
regulation of cellular amine metabolic processGO:003323830.015
regulation of nucleoside metabolic processGO:0009118500.015
response to copper ionGO:004668840.015
sterol homeostasisGO:005509240.015
response to organic cyclic compoundGO:0014070890.015
glycerolipid catabolic processGO:004650330.015
regulation of cellular amino acid metabolic processGO:000652100.015
regulation of steroid metabolic processGO:001921820.015
purine nucleoside monophosphate metabolic processGO:0009126500.015
regulation of protein metabolic processGO:00512462560.015
insulin receptor signaling pathwayGO:0008286250.015
response to organophosphorusGO:004668320.015
epithelial cell developmentGO:00020642740.015
spermatogenesisGO:00072832000.015
positive regulation of lipid metabolic processGO:004583440.015
sensory perceptionGO:00076001960.015
positive regulation of cellular biosynthetic processGO:00313283160.014
regulation of growthGO:00400082330.014
central nervous system developmentGO:00074172010.014
mitotic nuclear divisionGO:00070672130.014
positive regulation of macromolecule biosynthetic processGO:00105572830.014
defense response to gram negative bacteriumGO:0050829940.014
protein phosphorylationGO:00064681690.014
regulation of multi organism processGO:00439001310.014
developmental growthGO:00485892800.014
learningGO:0007612750.014
guanosine containing compound metabolic processGO:1901068740.014
regulation of defense responseGO:00313471020.014
negative regulation of protein metabolic processGO:0051248850.014
insecticide catabolic processGO:004670110.014
cellular response to dna damage stimulusGO:00069742230.014
regulation of cytoplasmic transportGO:1903649470.014
thioester metabolic processGO:003538330.014
response to temperature stimulusGO:00092661060.014
regulation of cellular protein metabolic processGO:00322682430.014
sulfur compound metabolic processGO:0006790590.014
negative regulation of phosphate metabolic processGO:0045936450.014
compound eye developmentGO:00487493070.014
negative regulation of immune system processGO:0002683500.014
medium chain fatty acid metabolic processGO:005179110.014
embryonic morphogenesisGO:00485982060.013
positive regulation of immune responseGO:0050778630.013
mrna metabolic processGO:00160711240.013
response to extracellular stimulusGO:00099911160.013
peptidyl amino acid modificationGO:00181931050.013
regulation of cell proliferationGO:00421271630.013
positive regulation of nucleoside metabolic processGO:0045979470.013
eye morphogenesisGO:00485922600.013
regulation of cell deathGO:00109411730.013
dephosphorylationGO:0016311510.013
organic hydroxy compound metabolic processGO:1901615830.013
negative regulation of developmental processGO:00510932010.013
connective tissue developmentGO:006144830.013
positive regulation of gene expressionGO:00106282900.013
positive regulation of hydrolase activityGO:0051345780.013
cell proliferationGO:00082832990.012
ion homeostasisGO:0050801550.012
humoral immune responseGO:00069591170.012
protein catabolic processGO:00301631010.012
nitrogen compound transportGO:0071705850.012
long term memoryGO:0007616620.012
cell migrationGO:00164772380.012
intracellular transportGO:00469072280.012
regulation of ras gtpase activityGO:0032318380.012
single organism intracellular transportGO:19025822070.012
rho protein signal transductionGO:0007266140.012
tube developmentGO:00352952440.012
secondary metabolite catabolic processGO:009048710.012
endomembrane system organizationGO:00102561190.012
regulation of purine nucleotide catabolic processGO:0033121480.012
skin developmentGO:0043588650.012
atp catabolic processGO:0006200380.012
inorganic ion transmembrane transportGO:0098660730.012
positive regulation of defense responseGO:0031349590.012
cellular metal ion homeostasisGO:0006875310.012
positive regulation of transcription dna templatedGO:00458932660.012
kidney developmentGO:000182230.012
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.012
negative regulation of phosphorus metabolic processGO:0010563450.012
positive regulation of nucleotide catabolic processGO:0030813460.012
eye developmentGO:00016543230.012
protein localizationGO:00081042840.012
positive regulation of cell migrationGO:003033520.012
biological adhesionGO:00226101380.012
regulation of stress activated mapk cascadeGO:0032872410.012
negative regulation of transcription dna templatedGO:00458922370.011
imaginal disc derived appendage morphogenesisGO:00351143950.011
extrinsic apoptotic signaling pathwayGO:009719110.011
rna processingGO:00063961470.011
cell motilityGO:00488702510.011
regulation of neuron projection developmentGO:0010975690.011
regulation of gtpase activityGO:0043087440.011
cellular response to starvationGO:0009267610.011
xenobiotic transportGO:004290810.011
nuclear divisionGO:00002803320.011
gland developmentGO:00487321910.011
positive regulation of phosphorylationGO:0042327870.011
lipid modificationGO:0030258240.011
negative regulation of cellular protein metabolic processGO:0032269850.011
phosphatidylinositol mediated signalingGO:004801540.011
innate immune responseGO:00450871440.011
regulation of multicellular organismal developmentGO:20000264140.011
proteolysisGO:00065081920.011
protein transportGO:00150311550.011
release of sequestered calcium ion into cytosolGO:005120910.011
peptidyl threonine phosphorylationGO:001810720.011
regulation of nucleotide metabolic processGO:0006140620.011
positive regulation of nucleotide metabolic processGO:0045981550.011
establishment of protein localizationGO:00451841630.011
negative regulation of homeostatic processGO:003284520.011
cellular response to nutrient levelsGO:0031669620.011
divalent metal ion transportGO:0070838260.011
antimicrobial humoral responseGO:0019730990.011
regulation of innate immune responseGO:0045088710.011
regulation of protein modification processGO:00313991120.011
negative regulation of cell deathGO:0060548810.011
acyl coa metabolic processGO:000663730.011
negative regulation of phosphorylationGO:0042326350.011
cation homeostasisGO:0055080510.010
peptidyl threonine modificationGO:001821030.010
positive regulation of cell motilityGO:200014730.010
protein import into nucleusGO:0006606510.010
spindle organizationGO:00070512530.010
cellular amide metabolic processGO:0043603800.010
glycerophospholipid metabolic processGO:0006650230.010
organic hydroxy compound biosynthetic processGO:1901617210.010
brain developmentGO:00074201200.010
purine nucleoside biosynthetic processGO:004245130.010
regulation of cellular component sizeGO:0032535980.010
mitochondrion organizationGO:0007005650.010
response to toxic substanceGO:0009636220.010
negative regulation of organelle organizationGO:0010639560.010
regulation of sequestering of calcium ionGO:005128230.010
acid secretionGO:004671710.010
negative regulation of intracellular signal transductionGO:1902532570.010
regulation of intracellular transportGO:0032386640.010
negative regulation of growthGO:0045926840.010
myotube cell developmentGO:001490430.010
spinal cord developmentGO:002151010.010
organelle fissionGO:00482853400.010

Gclc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.116
cardiovascular system diseaseDOID:128700.044
musculoskeletal system diseaseDOID:1700.022
nervous system diseaseDOID:86300.022
vascular diseaseDOID:17800.020
neurodegenerative diseaseDOID:128900.012
central nervous system diseaseDOID:33100.012
integumentary system diseaseDOID:1600.012
sensory system diseaseDOID:005015500.011
disease of cellular proliferationDOID:1456600.011
disease of metabolismDOID:001466700.010