Drosophila melanogaster

42 known processes

Upf2 (Dmel_CG2253)

CG2253 gene product from transcript CG2253-RA

(Aliases: upf2,UPF2,CG2253,Dmel\CG2253)

Upf2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
eggshell formationGO:00307031050.618
epithelial cell developmentGO:00020642740.567
ovarian follicle cell developmentGO:00307072480.470
nuclear transcribed mrna catabolic process nonsense mediated decayGO:000018480.424
cellular component assembly involved in morphogenesisGO:00109271510.364
chorion containing eggshell formationGO:00073041050.303
axon developmentGO:00615642970.295
compound eye morphogenesisGO:00017452490.267
chemotaxisGO:00069352490.247
pole plasm rna localizationGO:0007316520.243
taxisGO:00423303040.241
mrna metabolic processGO:00160711240.225
cell projection assemblyGO:0030031940.223
positive regulation of biosynthetic processGO:00098913160.216
cilium organizationGO:0044782410.196
epithelial cell differentiationGO:00308553220.187
response to abiotic stimulusGO:00096283410.183
neuron projection guidanceGO:00974852410.179
positive regulation of macromolecule metabolic processGO:00106044050.173
cellular catabolic processGO:00442483720.173
eye morphogenesisGO:00485922600.168
rna localizationGO:00064031150.167
columnar cuboidal epithelial cell differentiationGO:00020652560.166
regulation of catabolic processGO:00098941700.154
catabolic processGO:00090564090.149
photoreceptor cell developmentGO:0042461960.146
axon guidanceGO:00074112330.143
oocyte constructionGO:00073081120.141
immune responseGO:00069552460.139
protein modification processGO:00362114380.137
transcription from rna polymerase ii promoterGO:00063663680.128
positive regulation of nitrogen compound metabolic processGO:00511733540.127
negative regulation of gene expressionGO:00106293870.126
eye developmentGO:00016543230.123
columnar cuboidal epithelial cell developmentGO:00020662490.123
positive regulation of protein metabolic processGO:00512471280.113
oocyte developmentGO:00485991240.113
oocyte differentiationGO:00099941450.106
meiotic cell cycleGO:00513211710.106
positive regulation of nucleobase containing compound metabolic processGO:00459353320.106
organic substance catabolic processGO:19015753080.102
dorsal appendage formationGO:0046843470.101
regionalizationGO:00030024160.100
nuclear divisionGO:00002803320.098
eye photoreceptor cell developmentGO:0042462810.097
regulation of protein metabolic processGO:00512462560.097
embryonic pattern specificationGO:00098801740.096
positive regulation of rna metabolic processGO:00512542710.095
axonogenesisGO:00074092900.095
negative regulation of biosynthetic processGO:00098902770.093
nucleobase containing compound catabolic processGO:00346551650.091
positive regulation of cellular catabolic processGO:0031331950.089
dna metabolic processGO:00062592270.089
aromatic compound catabolic processGO:00194391660.088
phosphorylationGO:00163102940.088
regulation of apoptotic processGO:00429811300.087
regulation of growthGO:00400082330.086
regulation of transcription from rna polymerase ii promoterGO:00063573780.086
compound eye photoreceptor cell differentiationGO:00017511400.086
tissue morphogenesisGO:00487292970.086
compound eye developmentGO:00487493070.084
pole plasm mrna localizationGO:0019094490.083
reproductive behaviorGO:00190981220.083
negative regulation of cellular biosynthetic processGO:00313272770.083
tube developmentGO:00352952440.083
developmental growth involved in morphogenesisGO:0060560650.082
positive regulation of transcription dna templatedGO:00458932660.082
programmed cell deathGO:00125012570.075
nucleocytoplasmic transportGO:0006913720.073
positive regulation of cellular protein metabolic processGO:00322701180.073
intracellular signal transductionGO:00355563000.072
cellular ion homeostasisGO:0006873390.072
meiotic cell cycle processGO:19030461320.071
rna catabolic processGO:0006401370.071
regulation of cellular protein metabolic processGO:00322682430.070
establishment or maintenance of cytoskeleton polarityGO:0030952440.070
morphogenesis of an epitheliumGO:00020092760.069
covalent chromatin modificationGO:00165691060.069
heterocycle catabolic processGO:00467001660.068
reproductive structure developmentGO:0048608740.068
secondary metabolic processGO:0019748750.066
apoptotic processGO:00069151590.065
embryonic development via the syncytial blastodermGO:00017001480.064
cell deathGO:00082192790.064
pigment metabolic processGO:0042440840.063
embryo development ending in birth or egg hatchingGO:00097921520.063
positive regulation of response to stimulusGO:00485843230.063
positive regulation of nucleic acid templated transcriptionGO:19035082660.062
single organism intracellular transportGO:19025822070.061
regulation of phosphorus metabolic processGO:00511742100.061
sensory organ morphogenesisGO:00905962600.060
macromolecule catabolic processGO:00090571610.059
maternal determination of anterior posterior axis embryoGO:0008358740.059
chromatin organizationGO:00063252070.059
male gamete generationGO:00482322010.058
negative regulation of rna biosynthetic processGO:19026792400.058
open tracheal system developmentGO:00074242040.058
positive regulation of gene expressionGO:00106282900.058
mrna catabolic processGO:0006402330.058
deathGO:00162652840.057
multicellular organismal homeostasisGO:0048871410.057
negative regulation of cell communicationGO:00106482230.057
regulation of cellular response to stressGO:0080135890.056
multi organism reproductive behaviorGO:00447051210.055
transmembrane transportGO:00550851390.055
positive regulation of rna biosynthetic processGO:19026802660.055
macromolecular complex assemblyGO:00650032560.054
centrosome organizationGO:00512971630.054
blastoderm segmentationGO:00073501590.054
negative regulation of macromolecule biosynthetic processGO:00105582700.054
regulation of developmental growthGO:00486381740.054
regulation of proteolysisGO:0030162870.054
immune system processGO:00023763470.053
single organism cellular localizationGO:19025801800.052
cell migrationGO:00164772380.052
chromosome organizationGO:00512763600.051
stem cell developmentGO:0048864790.051
synapse assemblyGO:00074161430.051
oocyte axis specificationGO:00073091080.051
multi organism behaviorGO:00517051750.050
oocyte dorsal ventral axis specificationGO:0007310340.050
negative regulation of rna metabolic processGO:00512532510.049
cellular macromolecule catabolic processGO:00442651360.048
cell motilityGO:00488702510.048
regulation of notch signaling pathwayGO:00085931000.047
chemical homeostasisGO:0048878920.047
proteolysisGO:00065081920.046
ion homeostasisGO:0050801550.046
regulation of transportGO:00510491810.045
neuron recognitionGO:00080381010.045
positive regulation of signal transductionGO:00099672230.045
cellular response to chemical stimulusGO:00708871990.045
exocrine system developmentGO:00352721620.045
cell maturationGO:00484691440.045
organelle fissionGO:00482853400.045
mrna processingGO:00063971040.044
cilium assemblyGO:0042384380.044
digestive tract developmentGO:00485651490.044
regulation of organelle organizationGO:00330431960.044
larval developmentGO:00021641040.044
establishment or maintenance of cell polarityGO:00071631670.044
regulation of mrna metabolic processGO:1903311720.044
respiratory system developmentGO:00605412130.043
rna processingGO:00063961470.043
developmental maturationGO:00217001720.043
regulation of multicellular organismal developmentGO:20000264140.043
developmental programmed cell deathGO:00106231380.043
body morphogenesisGO:001017120.042
compound eye photoreceptor developmentGO:0042051780.042
negative regulation of cellular metabolic processGO:00313243820.042
meiotic nuclear divisionGO:00071261510.041
regulation of response to stressGO:00801342000.041
organelle assemblyGO:00709251980.040
positive regulation of intracellular signal transductionGO:19025331160.040
negative regulation of developmental processGO:00510932010.040
cellular macromolecule localizationGO:00707272200.039
ras protein signal transductionGO:0007265880.038
positive regulation of developmental processGO:00510941430.038
spermatid developmentGO:0007286980.037
purine ribonucleotide catabolic processGO:00091541090.037
eggshell chorion assemblyGO:0007306660.037
protein complex assemblyGO:00064612000.037
regulation of nervous system developmentGO:00519602480.037
axis specificationGO:00097981670.037
regulation of molecular functionGO:00650092170.036
negative regulation of cell differentiationGO:00455961430.036
border follicle cell migrationGO:00072981130.036
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.036
gene silencingGO:00164581380.036
endomembrane system organizationGO:00102561190.036
regulation of intracellular signal transductionGO:19025312360.036
innate immune responseGO:00450871440.036
protein modification by small protein conjugation or removalGO:00706471060.036
positive regulation of cell communicationGO:00106472500.035
regulation of synapse assemblyGO:0051963940.035
regulation of small gtpase mediated signal transductionGO:0051056930.035
regulation of phosphate metabolic processGO:00192202100.035
tube morphogenesisGO:00352391910.035
developmental growthGO:00485892800.034
regulation of anatomical structure sizeGO:00900661630.034
regulation of tube architecture open tracheal systemGO:0035152680.034
regulation of cell deathGO:00109411730.033
retina development in camera type eyeGO:006004140.033
homeostatic processGO:00425921990.033
response to sterolGO:0036314340.033
epithelial cell migrationGO:00106311480.033
localization of cellGO:00516742570.032
segmentationGO:00352822070.032
regulation of cell differentiationGO:00455953020.032
cellular protein modification processGO:00064644380.032
regulation of programmed cell deathGO:00430671520.032
dna packagingGO:0006323910.032
multicellular organism growthGO:0035264460.032
negative regulation of signalingGO:00230572190.032
regulation of gene silencingGO:0060968630.032
chromosome segregationGO:00070591570.032
negative regulation of nervous system developmentGO:0051961920.031
organonitrogen compound metabolic processGO:19015643180.031
response to organic cyclic compoundGO:0014070890.031
regulation of synapse structure and activityGO:00508031280.031
digestive system developmentGO:00551231490.031
negative regulation of nucleobase containing compound metabolic processGO:00459342610.031
ameboidal type cell migrationGO:00016671510.031
lipid metabolic processGO:00066291210.031
positive regulation of mrna catabolic processGO:006101450.030
cellular protein localizationGO:00346131600.030
male meiosisGO:0007140520.030
response to organic substanceGO:00100332840.030
positive regulation of proteolysisGO:0045862520.030
regulation of multi organism processGO:00439001310.030
chromatin modificationGO:00165681470.030
regulation of cell morphogenesisGO:00226041630.029
molting cycle processGO:0022404290.029
organic hydroxy compound metabolic processGO:1901615830.029
anterior posterior pattern specificationGO:00099521360.029
growthGO:00400073590.029
membrane organizationGO:00610241120.029
regulation of cellular catabolic processGO:00313291570.029
gland developmentGO:00487321910.029
negative regulation of response to stimulusGO:00485852580.029
regulation of cellular localizationGO:00603411360.028
regulation of protein modification processGO:00313991120.028
anterior posterior axis specificationGO:00099481090.028
negative regulation of signal transductionGO:00099682060.028
mapk cascadeGO:00001651070.028
hemopoiesisGO:0030097460.028
establishment or maintenance of microtubule cytoskeleton polarityGO:0030951410.028
regulation of cell developmentGO:00602842150.028
periodic partitioningGO:0007365290.028
regulation of organ morphogenesisGO:2000027780.027
regulation of cell proliferationGO:00421271630.027
developmental cell growthGO:0048588520.027
regulation of cellular component sizeGO:0032535980.027
gland morphogenesisGO:00226121450.026
response to hexoseGO:000974630.026
morphogenesis of follicular epitheliumGO:0016333360.026
protein transportGO:00150311550.026
stem cell differentiationGO:00488631170.026
establishment of localization in cellGO:00516494020.026
mitotic g2 dna damage checkpointGO:0007095690.026
positive regulation of growthGO:0045927750.026
endocytosisGO:00068973100.026
positive regulation of cellular biosynthetic processGO:00313283160.025
metal ion transportGO:0030001740.025
cell proliferationGO:00082832990.025
germarium derived oocyte fate determinationGO:0007294260.025
notch signaling pathwayGO:00072191200.025
positive regulation of phosphorylationGO:0042327870.025
spermatogenesisGO:00072832000.025
connective tissue developmentGO:006144830.025
protein localizationGO:00081042840.025
phagocytosisGO:00069092150.024
positive regulation of macromolecule biosynthetic processGO:00105572830.024
regulation of behaviorGO:0050795750.024
defense responseGO:00069523000.024
defense response to other organismGO:00985422250.024
establishment of protein localizationGO:00451841630.024
pole plasm oskar mrna localizationGO:0045451460.024
single organism biosynthetic processGO:00447112060.024
positive regulation of phosphate metabolic processGO:00459371390.024
cellular amide metabolic processGO:0043603800.024
multicellular organismal reproductive behaviorGO:00330571100.024
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.024
cellular cation homeostasisGO:0030003380.024
morphogenesis of embryonic epitheliumGO:0016331940.024
intracellular transportGO:00469072280.023
small gtpase mediated signal transductionGO:0007264880.023
dorsal ventral axis specificationGO:0009950660.023
regulation of cell cycle processGO:00105641810.023
mitotic g2 m transition checkpointGO:0044818700.023
posttranscriptional regulation of gene expressionGO:00106081450.023
negative regulation of nitrogen compound metabolic processGO:00511722650.023
cellular macromolecular complex assemblyGO:00346221530.023
extrinsic apoptotic signaling pathwayGO:009719110.023
g2 dna damage checkpointGO:0031572690.023
vesicle mediated transportGO:00161923810.023
positive regulation of cell deathGO:0010942690.022
photoreceptor cell differentiationGO:00465301700.022
organic substance transportGO:00717022570.022
positive regulation of multicellular organismal processGO:00512401430.022
neuromuscular junction developmentGO:00075281490.022
dna conformation changeGO:00711031050.022
regulation of catalytic activityGO:00507901850.022
regulation of epithelial cell differentiationGO:003085640.022
cell junction organizationGO:0034330570.022
regulation of chromatin silencingGO:0031935360.022
dorsal ventral pattern formationGO:00099531330.022
tripartite regional subdivisionGO:00073511030.022
anterior posterior axis specification embryoGO:00085951030.022
embryonic axis specificationGO:00005781070.022
locomotory behaviorGO:00076261760.022
matingGO:00076181200.021
autophagyGO:00069141080.021
positive regulation of purine nucleotide metabolic processGO:1900544550.021
establishment or maintenance of apical basal cell polarityGO:0035088340.021
cell recognitionGO:00080371020.021
microtubule organizing center organizationGO:00310231680.021
ion transmembrane transportGO:00342201220.021
embryonic organ developmentGO:0048568500.021
segment polarity determinationGO:0007367250.021
molting cycleGO:0042303560.021
protein complex biogenesisGO:00702712010.021
regulation of mrna catabolic processGO:006101350.021
positive regulation of signalingGO:00230562430.021
regulation of gene expression epigeneticGO:00400291280.021
pole plasm assemblyGO:0007315610.021
posttranscriptional gene silencingGO:0016441460.021
nucleoside metabolic processGO:00091161270.021
response to bacteriumGO:00096171980.021
anatomical structure homeostasisGO:0060249970.021
regulation of axon extension involved in axon guidanceGO:004884140.021
response to glucoseGO:000974920.020
regulation of multicellular organism growthGO:0040014400.020
negative regulation of cell deathGO:0060548810.020
cilium morphogenesisGO:0060271390.020
negative regulation of notch signaling pathwayGO:0045746410.020
regulation of dna metabolic processGO:0051052340.020
meiotic chromosome condensationGO:001003230.020
mitotic dna integrity checkpointGO:0044774750.020
sex differentiationGO:0007548810.020
cellular lipid metabolic processGO:0044255830.020
nuclear body organizationGO:003057560.020
cell growthGO:00160491080.020
purine containing compound metabolic processGO:00725211550.020
neuron projection extensionGO:1990138320.020
negative regulation of gene expression epigeneticGO:0045814770.019
cell cell junction organizationGO:0045216550.019
positive regulation of transportGO:0051050920.019
negative regulation of cell cycle processGO:00109481090.019
negative regulation of peptidyl tyrosine phosphorylationGO:005073260.019
salivary gland developmentGO:00074311620.019
dna damage checkpointGO:0000077780.019
regulation of embryonic pattern specificationGO:1902875270.019
positive regulation of multicellular organism growthGO:0040018210.019
regulation of cell maturationGO:1903429270.019
purine nucleoside triphosphate catabolic processGO:00091461080.019
neurological system processGO:00508773580.018
regulation of synapse organizationGO:00508071100.018
cellular response to oxygen levelsGO:0071453300.018
negative regulation of cellular component organizationGO:00511291080.018
negative regulation of growthGO:0045926840.018
eye photoreceptor cell differentiationGO:00017541450.018
ribonucleoside catabolic processGO:00424541120.018
negative regulation of nucleic acid templated transcriptionGO:19035072400.018
cellular homeostasisGO:0019725800.018
oocyte anterior posterior axis specificationGO:0007314720.018
carbohydrate derivative catabolic processGO:19011361180.018
response to external biotic stimulusGO:00432072930.018
positive regulation of protein modification processGO:0031401580.018
defense response to bacteriumGO:00427421780.018
cation transportGO:00068121100.018
endoderm formationGO:000170630.018
melanin metabolic processGO:0006582470.017
positive regulation of apoptotic processGO:0043065470.017
response to alcoholGO:0097305950.017
regulation of cellular amine metabolic processGO:003323830.017
telencephalon developmentGO:002153720.017
cellular nitrogen compound catabolic processGO:00442701650.017
oxoacid metabolic processGO:00434361030.017
positive regulation of mapk cascadeGO:0043410630.017
forebrain developmentGO:003090020.017
protein phosphorylationGO:00064681690.017
positive regulation of cellular component organizationGO:00511301560.017
nitrogen compound transportGO:0071705850.017
maintenance of epithelial integrity open tracheal systemGO:0035160120.017
imaginal disc derived wing vein specificationGO:0007474480.017
mating behaviorGO:00076171060.017
response to ecdysoneGO:0035075340.017
regulation of nucleoside metabolic processGO:0009118500.017
limb developmentGO:006017310.017
myotube cell developmentGO:001490430.017
regulation of reproductive processGO:2000241540.017
female meiotic divisionGO:0007143700.016
ribose phosphate metabolic processGO:00196931450.016
regulation of neuron projection developmentGO:0010975690.016
positive regulation of nucleotide metabolic processGO:0045981550.016
rna transportGO:0050658460.016
skeletal muscle fiber developmentGO:004874130.016
regulation of immune system processGO:00026821760.016
organic cyclic compound catabolic processGO:19013611680.016
positive regulation of cell proliferationGO:0008284470.016
positive regulation of catabolic processGO:00098961050.016
sensory perception of soundGO:0007605560.016
cellular response to dna damage stimulusGO:00069742230.016
dorsal closureGO:0007391790.016
detection of stimulusGO:00516061560.016
organophosphate metabolic processGO:00196371950.016
cellular component disassemblyGO:0022411460.016
small molecule metabolic processGO:00442813050.016
asymmetric protein localizationGO:0008105330.016
instar larval developmentGO:0002168550.016
regulation of anatomical structure morphogenesisGO:00226032420.016
intracellular mrna localization involved in anterior posterior axis specificationGO:0060811530.015
salivary gland morphogenesisGO:00074351450.015
cation homeostasisGO:0055080510.015
purine ribonucleoside catabolic processGO:00461301120.015
regulation of localizationGO:00328792750.015
camera type eye developmentGO:004301040.015
purine ribonucleoside triphosphate catabolic processGO:00092071080.015
regulation of ras protein signal transductionGO:0046578930.015
oocyte microtubule cytoskeleton organizationGO:0016325350.015
germarium derived oocyte differentiationGO:0030706290.015
cellular ketone metabolic processGO:0042180240.015
regulation of autophagyGO:0010506620.015
response to biotic stimulusGO:00096072940.015
regulation of phosphorylationGO:00423251470.015
development of primary sexual characteristicsGO:0045137500.015
establishment of protein localization to plasma membraneGO:009000290.015
regulation of tube size open tracheal systemGO:0035151430.015
secondary metabolite biosynthetic processGO:0044550240.015
single organism catabolic processGO:00447122280.015
synapse organizationGO:00508081960.015
limb morphogenesisGO:003510810.015
nucleotide metabolic processGO:00091171610.015
retina morphogenesis in camera type eyeGO:006004220.015
negative regulation of epithelial cell proliferationGO:005068040.015
regulation of protein catabolic processGO:0042176550.015
regulation of purine nucleotide metabolic processGO:1900542620.015
appendage morphogenesisGO:00351073970.015
adherens junction organizationGO:0034332270.015
regulation of response to external stimulusGO:00321011150.015
asymmetric cell divisionGO:0008356370.014
nucleus organizationGO:0006997450.014
protein modification by small protein conjugationGO:0032446790.014
synaptic growth at neuromuscular junctionGO:00511241190.014
multi multicellular organism processGO:00447061230.014
ethanolamine containing compound metabolic processGO:004243940.014
regulation of cellular amino acid metabolic processGO:000652100.014
chaeta developmentGO:0022416970.014
histone modificationGO:00165701060.014
positive regulation of developmental growthGO:0048639620.014
regulation of chromosome organizationGO:0033044640.014
purine nucleoside metabolic processGO:00422781270.014
positive regulation of phosphorus metabolic processGO:00105621390.014
apoptotic signaling pathwayGO:0097190270.014
cytoskeleton dependent intracellular transportGO:0030705440.014
regulation of heart rateGO:0002027110.014
learningGO:0007612750.014
ovarian follicle cell migrationGO:00072971210.014
cell migration involved in gastrulationGO:004207490.014
negative regulation of transcription dna templatedGO:00458922370.014
regulation of malpighian tubule diameterGO:003529730.014
negative regulation of apoptotic processGO:0043066630.014
jnk cascadeGO:0007254500.014
mitotic spindle organizationGO:00070522200.014
cellular response to hexose stimulusGO:007133110.014
positive regulation of protein transportGO:0051222370.013
single organism cell adhesionGO:0098602470.013
positive regulation of protein import into nucleusGO:0042307210.013
meiosis iGO:0007127590.013
organophosphate catabolic processGO:00464341120.013
regulation of immune responseGO:00507761180.013
salivary gland histolysisGO:0035070880.013
response to other organismGO:00517072930.013
morphogenesis of a branching epitheliumGO:0061138450.013
positive regulation of catalytic activityGO:00430851180.013
humoral immune responseGO:00069591170.013
response to oxygen levelsGO:0070482590.013
regulation of cell projection organizationGO:0031344920.013
regulation of intracellular transportGO:0032386640.013
purine nucleotide catabolic processGO:00061951090.013
regulation of cellular component biogenesisGO:00440872010.013
protein heterooligomerizationGO:005129140.013
amine metabolic processGO:0009308120.013
cellularizationGO:0007349900.013
reproductive system developmentGO:0061458740.013
cytoplasm organizationGO:0007028640.013
wnt signaling pathwayGO:0016055980.013
cellular chemical homeostasisGO:0055082400.013
mesenchymal cell developmentGO:001403110.013
purine ribonucleotide metabolic processGO:00091501450.013
multicellular organismal agingGO:00102591400.013
positive regulation of cellular component biogenesisGO:0044089800.013
gene silencing by rnaGO:0031047570.013
intracellular protein transportGO:00068861040.013
establishment of cell polarityGO:0030010400.013
centrosome cycleGO:00070981370.013
positive regulation of cysteine type endopeptidase activityGO:2001056240.012
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.012
positive regulation of cellular amino acid metabolic processGO:004576400.012
peptidyl threonine phosphorylationGO:001810720.012
negative regulation of cell developmentGO:0010721620.012
axon target recognitionGO:0007412160.012
response to decreased oxygen levelsGO:0036293580.012
single organismal cell cell adhesionGO:0016337450.012
regulation of protein phosphorylationGO:0001932640.012
cell junction assemblyGO:0034329420.012
positive regulation of hydrolase activityGO:0051345780.012

Upf2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.110
nervous system diseaseDOID:86300.030
sensory system diseaseDOID:005015500.025
organ system cancerDOID:005068600.021
disease of cellular proliferationDOID:1456600.021
cancerDOID:16200.021
musculoskeletal system diseaseDOID:1700.015
central nervous system diseaseDOID:33100.013