IMP: Integrative Multi-species Prediction

Drosophila melanogaster

15 known processes

l(2)37Cb (Dmel_CG10689)

lethal (2) 37Cb

(Aliases: Cb,CG10689,cg10689,Dmel\CG10689,l(2)E104)

Entrez: 35192
FLYBASE: FBgn0086444
UniProtKB: Q9VIZ3

Process Predictions
Disease Predictions

l(2)37Cb biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.787
dna metabolic process	GO:0006259	227	0.593
embryo development ending in birth or egg hatching	GO:0009792	152	0.354	Worm
pigmentation	GO:0043473	75	0.224
positive regulation of transcription dna templated	GO:0045893	266	0.223
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.190	Yeast
positive regulation of macromolecule metabolic process	GO:0010604	405	0.187
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.176
cellular macromolecular complex assembly	GO:0034622	153	0.172	Yeast
regionalization	GO:0003002	416	0.161
chromosome organization	GO:0051276	360	0.153
protein acetylation	GO:0006473	39	0.136
mrna processing	GO:0006397	104	0.133	Yeast
rna processing	GO:0006396	147	0.131	Yeast
ncrna 3 end processing	GO:0043628	17	0.131
regulation of dna metabolic process	GO:0051052	34	0.124
mrna metabolic process	GO:0016071	124	0.123	Yeast
larval development	GO:0002164	104	0.120	Worm
positive regulation of biosynthetic process	GO:0009891	316	0.119
internal protein amino acid acetylation	GO:0006475	38	0.117
peptidyl lysine modification	GO:0018205	57	0.116
positive regulation of cellular biosynthetic process	GO:0031328	316	0.115
regulation of programmed cell death	GO:0043067	152	0.114
cell proliferation	GO:0008283	299	0.111	Worm
endocytosis	GO:0006897	310	0.107
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.104
snrna 3 end processing	GO:0034472	14	0.103
positive regulation of gene expression	GO:0010628	290	0.102
cellular protein modification process	GO:0006464	438	0.099
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.095
protein dna complex subunit organization	GO:0071824	86	0.093
developmental pigmentation	GO:0048066	68	0.092
nucleobase containing compound catabolic process	GO:0034655	165	0.090	Yeast
small molecule metabolic process	GO:0044281	305	0.089	Yeast
death	GO:0016265	284	0.085
organonitrogen compound metabolic process	GO:1901564	318	0.085	Yeast
snrna metabolic process	GO:0016073	14	0.083
protein acylation	GO:0043543	42	0.082
positive regulation of rna metabolic process	GO:0051254	271	0.080
regulation of dna templated transcription elongation	GO:0032784	17	0.078
rna splicing via transesterification reactions	GO:0000375	73	0.078	Yeast
apoptotic process	GO:0006915	159	0.076
regulation of organelle organization	GO:0033043	196	0.072	Worm
immune system process	GO:0002376	347	0.071
macromolecular complex assembly	GO:0065003	256	0.070	Yeast
cellular catabolic process	GO:0044248	372	0.067	Yeast
meiotic cell cycle	GO:0051321	171	0.067	Worm
negative regulation of gene expression	GO:0010629	387	0.065
regulation of cell cycle	GO:0051726	291	0.065	Worm
positive regulation of molecular function	GO:0044093	136	0.064
protein dna complex assembly	GO:0065004	63	0.063
embryonic morphogenesis	GO:0048598	206	0.062	Zebrafish Worm
cellular nitrogen compound catabolic process	GO:0044270	165	0.059	Yeast
meiotic nuclear division	GO:0007126	151	0.058	Worm
heterocycle catabolic process	GO:0046700	166	0.058	Yeast
histone modification	GO:0016570	106	0.053
chromatin modification	GO:0016568	147	0.053
exocrine system development	GO:0035272	162	0.052
programmed cell death	GO:0012501	257	0.052
positive regulation of rna biosynthetic process	GO:1902680	266	0.052
chromatin organization	GO:0006325	207	0.051
dendrite morphogenesis	GO:0048813	199	0.051
ncrna metabolic process	GO:0034660	43	0.051	Yeast
organophosphate metabolic process	GO:0019637	195	0.051	Yeast
carbohydrate derivative metabolic process	GO:1901135	217	0.049	Yeast
response to other organism	GO:0051707	293	0.049
cell maturation	GO:0048469	144	0.048
aromatic compound catabolic process	GO:0019439	166	0.048	Yeast
negative regulation of cellular metabolic process	GO:0031324	382	0.047
dna replication	GO:0006260	48	0.047
regulation of protein metabolic process	GO:0051246	256	0.046
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.044
stem cell maintenance	GO:0019827	67	0.044
gene silencing	GO:0016458	138	0.044
snrna processing	GO:0016180	14	0.044
nucleotide metabolic process	GO:0009117	161	0.043	Yeast
internal peptidyl lysine acetylation	GO:0018393	38	0.043
response to abiotic stimulus	GO:0009628	341	0.042
imaginal disc derived wing morphogenesis	GO:0007476	337	0.041
intracellular signal transduction	GO:0035556	300	0.040
negative regulation of rna metabolic process	GO:0051253	251	0.039
single organism biosynthetic process	GO:0044711	206	0.039
rna 3 end processing	GO:0031123	45	0.039
organic acid metabolic process	GO:0006082	103	0.038
positive regulation of cellular component organization	GO:0051130	156	0.037
transcription from rna polymerase ii promoter	GO:0006366	368	0.037
protein modification process	GO:0036211	438	0.036
response to external biotic stimulus	GO:0043207	293	0.035
regulation of mrna splicing via spliceosome	GO:0048024	64	0.034
catabolic process	GO:0009056	409	0.034	Yeast
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.034
cell death	GO:0008219	279	0.034
cellular response to dna damage stimulus	GO:0006974	223	0.033
regulation of molecular function	GO:0065009	217	0.033
positive regulation of cell communication	GO:0010647	250	0.033
axon development	GO:0061564	297	0.033
organelle assembly	GO:0070925	198	0.033
histone acetylation	GO:0016573	38	0.032
positive regulation of catalytic activity	GO:0043085	118	0.032
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.032
rna splicing	GO:0008380	83	0.032	Yeast
peptidyl lysine acetylation	GO:0018394	39	0.031
response to bacterium	GO:0009617	198	0.031
brain development	GO:0007420	120	0.031
cellular amino acid metabolic process	GO:0006520	61	0.031
response to lipopolysaccharide	GO:0032496	4	0.031
vesicle mediated transport	GO:0016192	381	0.030
regulation of mrna processing	GO:0050684	71	0.030
homeostatic process	GO:0042592	199	0.030
carboxylic acid metabolic process	GO:0019752	92	0.029
positive regulation of cellular protein metabolic process	GO:0032270	118	0.029
central nervous system development	GO:0007417	201	0.029
taxis	GO:0042330	304	0.029
response to biotic stimulus	GO:0009607	294	0.028
nucleoside phosphate metabolic process	GO:0006753	162	0.028	Yeast
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.028
oxoacid metabolic process	GO:0043436	103	0.028
regulation of apoptotic process	GO:0042981	130	0.028
peptidyl amino acid modification	GO:0018193	105	0.027
organic substance catabolic process	GO:1901575	308	0.027	Yeast
rna transport	GO:0050658	46	0.027
dna packaging	GO:0006323	91	0.027
rna localization	GO:0006403	115	0.026
dna repair	GO:0006281	54	0.026
regulation of chromosome organization	GO:0033044	64	0.026
antimicrobial humoral response	GO:0019730	99	0.025
intracellular transport	GO:0046907	228	0.025
innate immune response	GO:0045087	144	0.025
purine ribonucleotide metabolic process	GO:0009150	145	0.025	Yeast
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.025
phagocytosis	GO:0006909	215	0.025
glycosyl compound metabolic process	GO:1901657	127	0.025	Yeast
dna templated transcription elongation	GO:0006354	18	0.025
neuron projection guidance	GO:0097485	241	0.024
imaginal disc derived appendage development	GO:0048737	399	0.024
tube morphogenesis	GO:0035239	191	0.024	Zebrafish
immune response	GO:0006955	246	0.024
positive regulation of hydrolase activity	GO:0051345	78	0.024
regulation of anatomical structure morphogenesis	GO:0022603	242	0.024
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.023
post embryonic appendage morphogenesis	GO:0035120	385	0.023
regulation of intracellular signal transduction	GO:1902531	236	0.023
regulation of developmental pigmentation	GO:0048070	24	0.023
axon guidance	GO:0007411	233	0.023
hindbrain development	GO:0030902	2	0.022
response to temperature stimulus	GO:0009266	106	0.022
rna polyadenylation	GO:0043631	12	0.022
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.022
histone h2a acetylation	GO:0043968	1	0.022
regulation of transcription elongation from rna polymerase ii promoter	GO:0034243	15	0.022
organic cyclic compound catabolic process	GO:1901361	168	0.022	Yeast
chromatin assembly or disassembly	GO:0006333	52	0.022
axonogenesis	GO:0007409	290	0.022
regulation of hydrolase activity	GO:0051336	97	0.021
positive regulation of protein modification process	GO:0031401	58	0.021
small gtpase mediated signal transduction	GO:0007264	88	0.021
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.021
dendrite development	GO:0016358	204	0.021
gene silencing by rna	GO:0031047	57	0.020
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.020	Yeast
response to oxygen containing compound	GO:1901700	200	0.020
proteolysis	GO:0006508	192	0.020
defense response	GO:0006952	300	0.020
regulation of rna splicing	GO:0043484	69	0.020
purine nucleoside metabolic process	GO:0042278	127	0.019	Yeast
cellular macromolecule catabolic process	GO:0044265	136	0.019
humoral immune response	GO:0006959	117	0.019
negative regulation of gene expression epigenetic	GO:0045814	77	0.018
response to lipid	GO:0033993	38	0.018
regulation of gene silencing	GO:0060968	63	0.018
regulation of cell division	GO:0051302	72	0.018	Worm
chromatin silencing	GO:0006342	76	0.018
establishment of localization in cell	GO:0051649	402	0.018
single organism catabolic process	GO:0044712	228	0.017	Yeast
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.017	Yeast
dna conformation change	GO:0071103	105	0.017
regulation of immune response	GO:0050776	118	0.017
nucleotide catabolic process	GO:0009166	109	0.017	Yeast
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.017	Yeast
ribose phosphate metabolic process	GO:0019693	145	0.016	Yeast
regulation of cell morphogenesis	GO:0022604	163	0.016
ribonucleotide metabolic process	GO:0009259	145	0.016	Yeast
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.016	Yeast
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.016
positive regulation of signaling	GO:0023056	243	0.016
muscle organ development	GO:0007517	127	0.016
transcription initiation from rna polymerase ii promoter	GO:0006367	25	0.016
appendage morphogenesis	GO:0035107	397	0.015
response to organic substance	GO:0010033	284	0.015
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.015
dna dependent dna replication	GO:0006261	17	0.015
purine ribonucleoside metabolic process	GO:0046128	127	0.015	Yeast
purine containing compound metabolic process	GO:0072521	155	0.015	Yeast
molting cycle process	GO:0022404	29	0.015
cellular response to organic substance	GO:0071310	132	0.015
cytoskeleton dependent intracellular transport	GO:0030705	44	0.015
rna interference	GO:0016246	27	0.014
regulation of cell death	GO:0010941	173	0.014
reproductive system development	GO:0061458	74	0.014	Worm
cell cycle dna replication	GO:0044786	23	0.014
localization of cell	GO:0051674	257	0.014
sensory organ morphogenesis	GO:0090596	260	0.014
morphogenesis of an epithelium	GO:0002009	276	0.014
dna biosynthetic process	GO:0071897	24	0.014
eye development	GO:0001654	323	0.013
posttranscriptional gene silencing	GO:0016441	46	0.013
covalent chromatin modification	GO:0016569	106	0.013
regulation of catalytic activity	GO:0050790	185	0.013
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.012
positive regulation of response to stimulus	GO:0048584	323	0.012
atp metabolic process	GO:0046034	49	0.012	Yeast
purine nucleotide catabolic process	GO:0006195	109	0.012	Yeast
nucleobase containing small molecule metabolic process	GO:0055086	174	0.012	Yeast
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.012
phosphorylation	GO:0016310	294	0.012
negative regulation of developmental process	GO:0051093	201	0.012
regulation of mrna metabolic process	GO:1903311	72	0.012
heart development	GO:0007507	82	0.012
chemotaxis	GO:0006935	249	0.012
negative regulation of cell communication	GO:0010648	223	0.012
regulation of cellular amino acid metabolic process	GO:0006521	0	0.012
single organism intracellular transport	GO:1902582	207	0.012
camera type eye development	GO:0043010	4	0.012
defense response to bacterium	GO:0042742	178	0.011
muscle structure development	GO:0061061	224	0.011
regulation of mitotic cell cycle	GO:0007346	190	0.011
gland development	GO:0048732	191	0.011
body morphogenesis	GO:0010171	2	0.011	Worm
regulation of neurogenesis	GO:0050767	158	0.011
mrna polyadenylation	GO:0006378	11	0.011
salivary gland morphogenesis	GO:0007435	145	0.011
cellular response to chemical stimulus	GO:0070887	199	0.011
cytoplasmic transport	GO:0016482	130	0.011
negative regulation of cell cycle process	GO:0010948	109	0.011
amine metabolic process	GO:0009308	12	0.011
cellular protein complex assembly	GO:0043623	71	0.011
stem cell differentiation	GO:0048863	117	0.011
mitotic sister chromatid segregation	GO:0000070	87	0.011
nucleoside monophosphate catabolic process	GO:0009125	39	0.011	Yeast
negative regulation of rna biosynthetic process	GO:1902679	240	0.011
response to heat	GO:0009408	63	0.011
sex differentiation	GO:0007548	81	0.010	Worm
alternative mrna splicing via spliceosome	GO:0000380	60	0.010
regulation of gene expression epigenetic	GO:0040029	128	0.010
negative regulation of cellular biosynthetic process	GO:0031327	277	0.010
oocyte differentiation	GO:0009994	145	0.010
positive regulation of intracellular signal transduction	GO:1902533	116	0.010
tube development	GO:0035295	244	0.010	Zebrafish
positive regulation of protein metabolic process	GO:0051247	128	0.010
oocyte development	GO:0048599	124	0.010
telomere organization	GO:0032200	21	0.010
carbohydrate derivative biosynthetic process	GO:1901137	85	0.010

l(2)37Cb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.020
	nervous system disease	DOID:863	0	0.011

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