IMP: Integrative Multi-species Prediction

Drosophila melanogaster

83 known processes

Irk2 (Dmel_CG4370)

Inwardly rectifying potassium channel 2

(Aliases: Dmel\CG4370,CG4370,irk2,CG10180,dKirII)

Entrez: 42770
FLYBASE: FBgn0039081
UniProtKB: Q8IMY7
UniProtKB: E1JIU5
UniProtKB: Q9VCL9

Process Predictions
Disease Predictions

Irk2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.684
response to light stimulus	GO:0009416	124	0.616	Rat
appendage development	GO:0048736	401	0.606
heart process	GO:0003015	37	0.523	Human Rat
kidney development	GO:0001822	3	0.434	Rat
negative regulation of signal transduction	GO:0009968	206	0.417
appendage morphogenesis	GO:0035107	397	0.404
negative regulation of signaling	GO:0023057	219	0.398
sensory perception	GO:0007600	196	0.370	Rat
bmp signaling pathway	GO:0030509	27	0.363
imaginal disc derived wing vein specification	GO:0007474	48	0.356
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.344
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.322
wing disc morphogenesis	GO:0007472	344	0.284
transcription from rna polymerase ii promoter	GO:0006366	368	0.246
circadian behavior	GO:0048512	76	0.243	Fly
circadian rhythm	GO:0007623	105	0.227	Fly
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.210
immune response regulating signaling pathway	GO:0002764	2	0.207
defense response	GO:0006952	300	0.203	Rat
response to monosaccharide	GO:0034284	4	0.201	Rat
imaginal disc derived appendage development	GO:0048737	399	0.198
response to abiotic stimulus	GO:0009628	341	0.187	Rat
response to glucose	GO:0009749	2	0.184	Rat
cellular response to organic substance	GO:0071310	132	0.184	Rat
cation transport	GO:0006812	110	0.183
negative regulation of insulin secretion	GO:0046676	1	0.183	Human
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.171
heart contraction	GO:0060047	26	0.169	Human Rat
regulation of mapk cascade	GO:0043408	92	0.166
regionalization	GO:0003002	416	0.154
imaginal disc derived wing morphogenesis	GO:0007476	337	0.153
negative regulation of cell communication	GO:0010648	223	0.147
regulation of system process	GO:0044057	36	0.138	Human Rat
locomotory behavior	GO:0007626	176	0.132	Fly
urogenital system development	GO:0001655	72	0.129	Rat
protein modification process	GO:0036211	438	0.126
regulation of bmp signaling pathway	GO:0030510	23	0.122
regulation of cell death	GO:0010941	173	0.118
regulation of transport	GO:0051049	181	0.116
detection of stimulus	GO:0051606	156	0.114
cation transmembrane transport	GO:0098655	88	0.111
ion transport	GO:0006811	145	0.110
response to radiation	GO:0009314	155	0.109	Rat
rhythmic process	GO:0048511	106	0.109	Fly
l amino acid import	GO:0043092	2	0.109	Rat
response to hexose	GO:0009746	3	0.104	Rat
mapk cascade	GO:0000165	107	0.101
negative regulation of response to stimulus	GO:0048585	258	0.099
regulation of cellular response to growth factor stimulus	GO:0090287	13	0.099
regulation of protein metabolic process	GO:0051246	256	0.098
organic anion transport	GO:0015711	28	0.097	Rat
phosphorylation	GO:0016310	294	0.096
cellular homeostasis	GO:0019725	80	0.093	Rat
organic acid transport	GO:0015849	18	0.092	Rat
response to organic substance	GO:0010033	284	0.092	Human Rat
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.089
organic substance transport	GO:0071702	257	0.087	Human Rat
positive regulation of protein metabolic process	GO:0051247	128	0.083
circulatory system process	GO:0003013	37	0.083	Human Rat
intracellular signal transduction	GO:0035556	300	0.082
regulation of multicellular organismal development	GO:2000026	414	0.082
post embryonic appendage morphogenesis	GO:0035120	385	0.080
regulation of phosphorus metabolic process	GO:0051174	210	0.079
circulatory system development	GO:0072359	82	0.077
response to endogenous stimulus	GO:0009719	119	0.076	Human Rat
cellular response to chemical stimulus	GO:0070887	199	0.076	Rat
germ line stem cell division	GO:0042078	25	0.074
blood circulation	GO:0008015	26	0.070	Human Rat
renal system development	GO:0072001	72	0.070	Rat
amino acid transport	GO:0006865	12	0.069	Rat
cellular response to radiation	GO:0071478	52	0.069
regulation of cellular ketone metabolic process	GO:0010565	3	0.069
positive regulation of cell communication	GO:0010647	250	0.069
neurological system process	GO:0050877	358	0.069	Human Rat
protein complex assembly	GO:0006461	200	0.068	Human Rat
response to organophosphorus	GO:0046683	2	0.068	Human
protein complex biogenesis	GO:0070271	201	0.067	Human Rat
protein phosphorylation	GO:0006468	169	0.064
cellular response to abiotic stimulus	GO:0071214	58	0.063	Rat
establishment of localization in cell	GO:0051649	402	0.062	Human
regulation of immune system process	GO:0002682	176	0.062
regulation of cellular amino acid metabolic process	GO:0006521	0	0.060
biological adhesion	GO:0022610	138	0.060
immune response activating signal transduction	GO:0002757	2	0.060
response to nitrogen compound	GO:1901698	90	0.058	Human Rat
negative regulation of cellular metabolic process	GO:0031324	382	0.058
regulation of phosphorylation	GO:0042325	147	0.057
cellular potassium ion transport	GO:0071804	18	0.056
cellular protein modification process	GO:0006464	438	0.056
cellular response to mechanical stimulus	GO:0071260	2	0.056	Rat
endocytosis	GO:0006897	310	0.055
proteolysis	GO:0006508	192	0.055
axis specification	GO:0009798	167	0.054
muscle contraction	GO:0006936	13	0.054	Human Rat
signal transduction by phosphorylation	GO:0023014	107	0.053
homeostatic process	GO:0042592	199	0.053	Rat
cranial nerve development	GO:0021545	1	0.053	Rat
response to alcohol	GO:0097305	95	0.053	Rat
cellular ion homeostasis	GO:0006873	39	0.053
regulation of apoptotic process	GO:0042981	130	0.052
regulation of heart contraction	GO:0008016	21	0.051	Human Rat
positive regulation of response to stimulus	GO:0048584	323	0.051
tissue migration	GO:0090130	155	0.050
actin mediated cell contraction	GO:0070252	21	0.049	Rat
muscle system process	GO:0003012	21	0.049	Human Rat
organonitrogen compound metabolic process	GO:1901564	318	0.049
immune response	GO:0006955	246	0.048
muscle structure development	GO:0061061	224	0.048
rhythmic behavior	GO:0007622	76	0.048	Fly
small molecule metabolic process	GO:0044281	305	0.047
regulation of transmembrane transport	GO:0034762	27	0.046
epithelial cell development	GO:0002064	274	0.046
developmental growth	GO:0048589	280	0.046
positive regulation of macromolecule metabolic process	GO:0010604	405	0.045
positive regulation of molecular function	GO:0044093	136	0.044	Rat
cell proliferation	GO:0008283	299	0.043
oxoacid metabolic process	GO:0043436	103	0.043
response to lipopolysaccharide	GO:0032496	4	0.043
cytokinesis	GO:0000910	90	0.042
detection of external stimulus	GO:0009581	66	0.041
detection of light stimulus	GO:0009583	58	0.041
cellular response to nitrogen compound	GO:1901699	51	0.041	Rat
positive regulation of transport	GO:0051050	92	0.041	Rat
cell death	GO:0008219	279	0.041
cellular ketone metabolic process	GO:0042180	24	0.041
positive regulation of cell migration	GO:0030335	2	0.040
cellular response to lipopolysaccharide	GO:0071222	3	0.040
ion transmembrane transport	GO:0034220	122	0.040
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.040
regulation of phosphate metabolic process	GO:0019220	210	0.040
negative regulation of peptide secretion	GO:0002792	1	0.040	Human
endodermal cell fate commitment	GO:0001711	3	0.039
locomotor rhythm	GO:0045475	56	0.039	Fly
regulation of cell proliferation	GO:0042127	163	0.039
growth	GO:0040007	359	0.039
cellular response to molecule of bacterial origin	GO:0071219	3	0.039
chemical homeostasis	GO:0048878	92	0.039	Rat
ovarian follicle cell development	GO:0030707	248	0.038
negative regulation of smoothened signaling pathway	GO:0045879	16	0.038
regulation of response to stress	GO:0080134	200	0.038
positive regulation of cellular protein metabolic process	GO:0032270	118	0.038
carboxylic acid transport	GO:0046942	18	0.038	Rat
detection of stimulus involved in sensory perception	GO:0050906	92	0.037
positive regulation of cell motility	GO:2000147	3	0.036
nephron development	GO:0072006	3	0.036
cellular chemical homeostasis	GO:0055082	40	0.036	Rat
organic acid metabolic process	GO:0006082	103	0.036
connective tissue development	GO:0061448	3	0.035
regulation of pathway restricted smad protein phosphorylation	GO:0060393	1	0.034
negative regulation of phosphate metabolic process	GO:0045936	45	0.034
regulation of muscle contraction	GO:0006937	5	0.034	Human Rat
regulation of protein modification process	GO:0031399	112	0.034
epithelial cell migration	GO:0010631	148	0.034
positive regulation of ion transmembrane transporter activity	GO:0032414	4	0.033	Rat
endoderm formation	GO:0001706	3	0.033
cellular response to monosaccharide stimulus	GO:0071326	2	0.033	Rat
positive regulation of cellular biosynthetic process	GO:0031328	316	0.033
anterior posterior axis specification embryo	GO:0008595	103	0.033
cellular response to organic cyclic compound	GO:0071407	32	0.032	Rat
dorsal ventral pattern formation	GO:0009953	133	0.032
positive regulation of signal transduction	GO:0009967	223	0.032
single organism biosynthetic process	GO:0044711	206	0.032
body morphogenesis	GO:0010171	2	0.032
response to oxygen containing compound	GO:1901700	200	0.031	Human Rat
embryonic axis specification	GO:0000578	107	0.031
vesicle mediated transport	GO:0016192	381	0.031
localization of cell	GO:0051674	257	0.031
embryonic morphogenesis	GO:0048598	206	0.031
peptidyl threonine phosphorylation	GO:0018107	2	0.031
anterior posterior axis specification	GO:0009948	109	0.030
regulation of programmed cell death	GO:0043067	152	0.030
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.030
sensory perception of chemical stimulus	GO:0007606	116	0.029
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.029
potassium ion transport	GO:0006813	20	0.029
positive regulation of cellular amine metabolic process	GO:0033240	0	0.029
regulation of cellular component movement	GO:0051270	42	0.029	Human Rat
macromolecular complex assembly	GO:0065003	256	0.029	Human Rat
regulation of membrane potential	GO:0042391	35	0.028
determination of ventral identity	GO:0048264	1	0.028
regulation of blood circulation	GO:1903522	21	0.028	Human Rat
regulation of map kinase activity	GO:0043405	17	0.028
inorganic ion transmembrane transport	GO:0098660	73	0.028
negative regulation of multicellular organismal process	GO:0051241	142	0.028
response to external biotic stimulus	GO:0043207	293	0.028
smoothened signaling pathway	GO:0007224	49	0.028
regulation of mitotic cell cycle	GO:0007346	190	0.028
embryonic pattern specification	GO:0009880	174	0.027
pigmentation	GO:0043473	75	0.027
regulation of localization	GO:0032879	275	0.027
eggshell formation	GO:0030703	105	0.027
eye development	GO:0001654	323	0.027
cellular metal ion homeostasis	GO:0006875	31	0.026
single organism carbohydrate metabolic process	GO:0044723	72	0.026	Human
positive regulation of immune response	GO:0050778	63	0.026
aging	GO:0007568	143	0.026
positive regulation of developmental process	GO:0051094	143	0.026
negative regulation of peptide hormone secretion	GO:0090278	1	0.026	Human
death	GO:0016265	284	0.025
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.025
positive regulation of immune system process	GO:0002684	68	0.025
negative regulation of gene expression	GO:0010629	387	0.025
regulation of epithelial cell proliferation	GO:0050678	4	0.025
anatomical structure homeostasis	GO:0060249	97	0.025
establishment of protein localization	GO:0045184	163	0.025
cellular amino acid metabolic process	GO:0006520	61	0.025
carbohydrate derivative metabolic process	GO:1901135	217	0.025
nephron tubule development	GO:0072080	3	0.025
negative regulation of bmp signaling pathway	GO:0030514	12	0.025
cellular response to organonitrogen compound	GO:0071417	36	0.024	Rat
response to bacterium	GO:0009617	198	0.024
phototransduction	GO:0007602	52	0.024
regulation of immune response	GO:0050776	118	0.024
jnk cascade	GO:0007254	50	0.024
negative regulation of phosphorus metabolic process	GO:0010563	45	0.024
catabolic process	GO:0009056	409	0.024
skeletal muscle fiber development	GO:0048741	3	0.024
kidney epithelium development	GO:0072073	3	0.024
positive regulation of phosphorus metabolic process	GO:0010562	139	0.024
kidney morphogenesis	GO:0060993	3	0.024
positive regulation of multicellular organismal process	GO:0051240	143	0.024
epithelial cell differentiation	GO:0030855	322	0.024
response to purine containing compound	GO:0014074	12	0.023	Human
negative regulation of kinase activity	GO:0033673	16	0.023
cellular response to endogenous stimulus	GO:0071495	80	0.023	Rat
negative regulation of mapk cascade	GO:0043409	23	0.023
peptidyl amino acid modification	GO:0018193	105	0.023
cell adhesion	GO:0007155	136	0.023
regulation of cellular amine metabolic process	GO:0033238	3	0.023
cellular response to ionizing radiation	GO:0071479	15	0.022
regulation of transmembrane transporter activity	GO:0022898	6	0.022	Rat
chromatin organization	GO:0006325	207	0.022
positive regulation of phosphate metabolic process	GO:0045937	139	0.022
striated muscle contraction	GO:0006941	5	0.022	Human Rat
amine metabolic process	GO:0009308	12	0.022
regulation of developmental growth	GO:0048638	174	0.022
hematopoietic or lymphoid organ development	GO:0048534	57	0.022
eye antennal disc development	GO:0035214	60	0.022
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.022
regulation of cell cycle	GO:0051726	291	0.021
regulation of smoothened signaling pathway	GO:0008589	28	0.021
secretion by cell	GO:0032940	101	0.021	Human
hemopoiesis	GO:0030097	46	0.021
cellular response to biotic stimulus	GO:0071216	4	0.021
cellular response to oxygen containing compound	GO:1901701	79	0.021	Rat
regulation of anatomical structure morphogenesis	GO:0022603	242	0.021
regulation of synaptic transmission	GO:0050804	69	0.021
purine nucleotide metabolic process	GO:0006163	146	0.021
actin filament based movement	GO:0030048	26	0.021	Rat
terminal region determination	GO:0007362	25	0.021
regulation of organ morphogenesis	GO:2000027	78	0.021
regulation of intracellular signal transduction	GO:1902531	236	0.021
positive regulation of protein transport	GO:0051222	37	0.020
taxis	GO:0042330	304	0.020
regulation of reproductive process	GO:2000241	54	0.020
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	6	0.020
myotube cell development	GO:0014904	3	0.020
compound eye development	GO:0048749	307	0.020
programmed cell death	GO:0012501	257	0.020
carbohydrate homeostasis	GO:0033500	12	0.020	Rat
positive regulation of cell proliferation	GO:0008284	47	0.020
nerve development	GO:0021675	6	0.020	Rat
regulation of molecular function	GO:0065009	217	0.020	Rat
regulation of catalytic activity	GO:0050790	185	0.020
detection of visible light	GO:0009584	38	0.020
regulation of protein phosphorylation	GO:0001932	64	0.020
determination of dorsal ventral asymmetry	GO:0048262	3	0.019
apoptotic process	GO:0006915	159	0.019
regulation of defense response	GO:0031347	102	0.019
cellular response to growth factor stimulus	GO:0071363	30	0.019
forebrain development	GO:0030900	2	0.019
retina development in camera type eye	GO:0060041	4	0.019
response to organic cyclic compound	GO:0014070	89	0.019	Human Rat
oocyte development	GO:0048599	124	0.019
gland morphogenesis	GO:0022612	145	0.019
monocarboxylic acid transport	GO:0015718	3	0.019
erbb signaling pathway	GO:0038127	58	0.019
negative regulation of cell proliferation	GO:0008285	69	0.019
cellular amide metabolic process	GO:0043603	80	0.019
proteoglycan metabolic process	GO:0006029	10	0.018
response to lipid	GO:0033993	38	0.018	Rat
cell type specific apoptotic process	GO:0097285	38	0.018
compound eye morphogenesis	GO:0001745	249	0.018
nephron morphogenesis	GO:0072028	3	0.018
negative regulation of fibroblast growth factor receptor signaling pathway	GO:0040037	2	0.018
immune system development	GO:0002520	57	0.018
regulation of notch signaling pathway	GO:0008593	100	0.018
learning or memory	GO:0007611	141	0.017
regulation of decapentaplegic signaling pathway	GO:0090097	8	0.017
single organism behavior	GO:0044708	391	0.017	Fly
carboxylic acid metabolic process	GO:0019752	92	0.017
signal release	GO:0023061	49	0.017	Human
cellular cation homeostasis	GO:0030003	38	0.017
cellular response to hexose stimulus	GO:0071331	1	0.017	Rat
carbohydrate derivative biosynthetic process	GO:1901137	85	0.017
regulation of protein serine threonine kinase activity	GO:0071900	25	0.017
cytokinetic process	GO:0032506	27	0.017
sensory organ morphogenesis	GO:0090596	260	0.017
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.017
developmental pigmentation	GO:0048066	68	0.017
carbohydrate metabolic process	GO:0005975	82	0.017	Human
regulation of transferase activity	GO:0051338	58	0.017
endomembrane system organization	GO:0010256	119	0.017
organic substance catabolic process	GO:1901575	308	0.016
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.016
negative regulation of developmental process	GO:0051093	201	0.016
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.016
response to growth factor	GO:0070848	31	0.016
nephron epithelium development	GO:0072009	3	0.016
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.016
regulation of innate immune response	GO:0045088	71	0.016
eye photoreceptor cell differentiation	GO:0001754	145	0.016
brain development	GO:0007420	120	0.016
eye pigmentation	GO:0048069	43	0.016
purine containing compound metabolic process	GO:0072521	155	0.016
nitrogen compound transport	GO:0071705	85	0.016	Human Rat
lateral inhibition	GO:0046331	206	0.016
response to biotic stimulus	GO:0009607	294	0.016
inorganic cation transmembrane transport	GO:0098662	61	0.016
regulation of organ formation	GO:0003156	3	0.016
negative regulation of erbb signaling pathway	GO:1901185	29	0.016
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.016
stem cell development	GO:0048864	79	0.016
positive regulation of signaling	GO:0023056	243	0.016
positive regulation of protein modification process	GO:0031401	58	0.016
columnar cuboidal epithelial cell development	GO:0002066	249	0.016
covalent chromatin modification	GO:0016569	106	0.016
wnt signaling pathway	GO:0016055	98	0.016
positive regulation of pathway restricted smad protein phosphorylation	GO:0010862	1	0.015
negative regulation of rna metabolic process	GO:0051253	251	0.015
positive regulation of defense response	GO:0031349	59	0.015
eye morphogenesis	GO:0048592	260	0.015
metal ion homeostasis	GO:0055065	44	0.015
limb development	GO:0060173	1	0.015
purine ribonucleotide metabolic process	GO:0009150	145	0.015
cell migration	GO:0016477	238	0.015
regulation of multi organism process	GO:0043900	131	0.015
regulation of cell differentiation	GO:0045595	302	0.015
jak stat cascade	GO:0007259	49	0.015
posttranscriptional regulation of gene expression	GO:0010608	145	0.015
positive regulation of phosphorylation	GO:0042327	87	0.015
malpighian tubule development	GO:0072002	64	0.015
multicellular organismal aging	GO:0010259	140	0.015
cardiovascular system development	GO:0072358	82	0.015
cellular response to external stimulus	GO:0071496	66	0.015	Rat
cellular response to light stimulus	GO:0071482	37	0.015
response to organonitrogen compound	GO:0010243	75	0.015	Human Rat
wing disc pattern formation	GO:0035222	66	0.015
photoreceptor cell differentiation	GO:0046530	170	0.015
gland development	GO:0048732	191	0.015
positive regulation of cell projection organization	GO:0031346	29	0.015
response to oxygen levels	GO:0070482	59	0.015
activation of innate immune response	GO:0002218	4	0.015
cellular response to lipid	GO:0071396	20	0.014
protein processing	GO:0016485	68	0.014
negative regulation of phosphorylation	GO:0042326	35	0.014
negative regulation of protein metabolic process	GO:0051248	85	0.014
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	26	0.014
neuromuscular junction development	GO:0007528	149	0.014
developmental maturation	GO:0021700	172	0.014
nucleobase containing small molecule metabolic process	GO:0055086	174	0.014
cellular amine metabolic process	GO:0044106	12	0.014
ribose phosphate metabolic process	GO:0019693	145	0.014
adult behavior	GO:0030534	137	0.014
anterior posterior pattern specification	GO:0009952	136	0.014
negative regulation of cell death	GO:0060548	81	0.014
ion homeostasis	GO:0050801	55	0.013
amino acid import	GO:0043090	5	0.013	Rat
response to hormone	GO:0009725	45	0.013	Rat
proteasomal protein catabolic process	GO:0010498	59	0.013
cognition	GO:0050890	141	0.013
peptide metabolic process	GO:0006518	80	0.013
response to ketone	GO:1901654	34	0.013	Rat
ribonucleoside metabolic process	GO:0009119	127	0.013
protein catabolic process	GO:0030163	101	0.013
positive regulation of rna biosynthetic process	GO:1902680	266	0.013
peptidyl threonine modification	GO:0018210	3	0.013
mitotic nuclear division	GO:0007067	213	0.013
segmentation	GO:0035282	207	0.013
negative regulation of catalytic activity	GO:0043086	42	0.013
nephron tubule morphogenesis	GO:0072078	3	0.013
nephron epithelium morphogenesis	GO:0072088	3	0.013
muscle organ development	GO:0007517	127	0.013
regulation of ion transmembrane transporter activity	GO:0032412	6	0.013	Rat
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.013
single organism intracellular transport	GO:1902582	207	0.013
zygotic determination of anterior posterior axis embryo	GO:0007354	27	0.013
carbohydrate derivative catabolic process	GO:1901136	118	0.013
neuropeptide signaling pathway	GO:0007218	45	0.013
endodermal cell differentiation	GO:0035987	3	0.013
organic hydroxy compound metabolic process	GO:1901615	83	0.012
notch signaling pathway	GO:0007219	120	0.012
neuroblast proliferation	GO:0007405	74	0.012
chemotaxis	GO:0006935	249	0.012
negative regulation of epithelial cell proliferation	GO:0050680	4	0.012
chromosome separation	GO:0051304	42	0.012
regulation of cellular localization	GO:0060341	136	0.012	Human
organophosphate catabolic process	GO:0046434	112	0.012
molting cycle chitin based cuticle	GO:0007591	56	0.012
chorion containing eggshell formation	GO:0007304	105	0.012
regulation of ion transport	GO:0043269	39	0.012
negative regulation of catabolic process	GO:0009895	36	0.012
pigment metabolic process	GO:0042440	84	0.012
oocyte differentiation	GO:0009994	145	0.012
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.012
regulation of cellular response to oxidative stress	GO:1900407	4	0.012
positive regulation of catalytic activity	GO:0043085	118	0.012
positive regulation of programmed cell death	GO:0043068	62	0.012
negative regulation of hormone biosynthetic process	GO:0032353	1	0.012
smoothened signaling pathway involved in ventral spinal cord patterning	GO:0021910	0	0.012
sex differentiation	GO:0007548	81	0.012
cellular response to dna damage stimulus	GO:0006974	223	0.012
negative regulation of intracellular signal transduction	GO:1902532	57	0.012
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.012
regulation of cell adhesion	GO:0030155	27	0.012
oocyte axis specification	GO:0007309	108	0.012
chromosome organization	GO:0051276	360	0.012
response to alkaloid	GO:0043279	26	0.012	Rat
leg disc development	GO:0035218	92	0.012
negative regulation of cellular protein metabolic process	GO:0032269	85	0.012
regulation of cellular component biogenesis	GO:0044087	201	0.012
negative regulation of transferase activity	GO:0051348	18	0.012
potassium ion transmembrane transport	GO:0071805	18	0.012
mitotic cytokinesis	GO:0000281	50	0.012
regulation of protein transport	GO:0051223	57	0.012
reproductive system development	GO:0061458	74	0.011
pigment biosynthetic process	GO:0046148	36	0.011
limb morphogenesis	GO:0035108	1	0.011
regulation of protein kinase activity	GO:0045859	51	0.011
oocyte dorsal ventral axis specification	GO:0007310	34	0.011
retina morphogenesis in camera type eye	GO:0060042	2	0.011
nucleotide metabolic process	GO:0009117	161	0.011
detection of chemical stimulus	GO:0009593	93	0.011
extracellular structure organization	GO:0043062	46	0.011
regulation of purine nucleotide metabolic process	GO:1900542	62	0.011
positive regulation of response to external stimulus	GO:0032103	44	0.011
negative regulation of protein phosphorylation	GO:0001933	17	0.011
stem cell maintenance	GO:0019827	67	0.011
cellular response to carbohydrate stimulus	GO:0071322	4	0.011	Rat
negative regulation of cellular biosynthetic process	GO:0031327	277	0.011
spinal cord dorsal ventral patterning	GO:0021513	1	0.011
protein modification by small protein conjugation	GO:0032446	79	0.011
morphogenesis of a branching epithelium	GO:0061138	45	0.011
eye photoreceptor cell development	GO:0042462	81	0.011
positive regulation of rna metabolic process	GO:0051254	271	0.011
regulation of peptidyl tyrosine phosphorylation	GO:0050730	10	0.011
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.011
positive regulation of transcription dna templated	GO:0045893	266	0.011
negative regulation of rna biosynthetic process	GO:1902679	240	0.011
cell cycle arrest	GO:0007050	4	0.011
anion transport	GO:0006820	41	0.011	Rat
tissue homeostasis	GO:0001894	36	0.011
germ line stem cell maintenance	GO:0030718	50	0.011
regulation of establishment of protein localization	GO:0070201	61	0.011
regulation of cellular protein metabolic process	GO:0032268	243	0.011
regulation of intracellular transport	GO:0032386	64	0.011
extrinsic apoptotic signaling pathway	GO:0097191	1	0.011
glycosyl compound biosynthetic process	GO:1901659	3	0.011
stem cell division	GO:0017145	69	0.011
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.011
activation of protein kinase activity	GO:0032147	12	0.011
regulation of jnk cascade	GO:0046328	40	0.011
mitotic sister chromatid segregation	GO:0000070	87	0.011
response to carbohydrate	GO:0009743	15	0.011	Rat
stress activated mapk cascade	GO:0051403	52	0.011
regulation of secretion by cell	GO:1903530	39	0.011	Human
regulation of cellular catabolic process	GO:0031329	157	0.011

Irk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
urinary system disease	DOID:18	0.208	Human
kidney disease	DOID:557	0.208	Human
disease of anatomical entity	DOID:7	0.208	Human
renal tubular transport disease	DOID:447	0.208	Human
bartter disease	DOID:445	0.208	Human
cardiovascular system disease	DOID:1287	0.201	Human
heart conduction disease	DOID:10273	0.201	Human
nervous system disease	DOID:863	0.109	Human
disease of metabolism	DOID:0014667	0.095	Human
carbohydrate metabolism disease	DOID:0050013	0.095	Human
acquired metabolic disease	DOID:0060158	0.095	Human
glucose metabolism disease	DOID:4194	0.095	Human
diabetes mellitus	DOID:9351	0.075	Human
type 2 diabetes mellitus	DOID:9352	0.075	Human
inherited metabolic disorder	DOID:655	0.054	Human
sensory system disease	DOID:0050155	0.047	Human
eye and adnexa disease	DOID:1492	0.047	Human
eye disease	DOID:5614	0.047	Human
cancer	DOID:162	0.022
disease of cellular proliferation	DOID:14566	0.022
musculoskeletal system disease	DOID:17	0.014
vascular disease	DOID:178	0.013
artery disease	DOID:0050828	0.013
hypertension	DOID:10763	0.013
central nervous system disease	DOID:331	0.013
organ system cancer	DOID:0050686	0.012
auditory system disease	DOID:2742	0.011	Human

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