Drosophila melanogaster

87 known processes

l(2)NC136 (Dmel_CG8426)

lethal (2) NC136

(Aliases: not3,NOT3/5,CG8426,not3/5,Dmel\CG8426,CNOT3)

l(2)NC136 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
mitotic g2 m transition checkpointGO:0044818700.738
mitotic dna integrity checkpointGO:0044774750.490
mitotic g2 dna damage checkpointGO:0007095690.336
regulation of mitotic cell cycleGO:00073461900.259
mitotic dna damage checkpointGO:0044773740.233
mitotic cell cycle checkpointGO:0007093880.225
g2 dna damage checkpointGO:0031572690.221
cell cycle phase transitionGO:00447701400.199
centrosome organizationGO:00512971630.182
mitotic cell cycle phase transitionGO:00447721380.169
regulation of mitotic cell cycle phase transitionGO:19019901300.144
negative regulation of mitotic cell cycle phase transitionGO:19019911030.139
embryo development ending in birth or egg hatchingGO:00097921520.130
Worm
body morphogenesisGO:001017120.126
heterocycle catabolic processGO:00467001660.126
cellular response to dna damage stimulusGO:00069742230.110
cellular macromolecule catabolic processGO:00442651360.102
regulation of cell cycle processGO:00105641810.095
regulation of cell cycle phase transitionGO:19019871300.093
immune system developmentGO:0002520570.085
regulation of organelle organizationGO:00330431960.085
cell cycle checkpointGO:0000075950.084
dendrite developmentGO:00163582040.084
negative regulation of cell cycleGO:00457861160.074
ribonucleoprotein complex disassemblyGO:003298810.073
catabolic processGO:00090564090.072
negative regulation of cell cycle processGO:00109481090.072
rna processingGO:00063961470.069
regulation of transcription from rna polymerase ii promoterGO:00063573780.068
posttranscriptional regulation of gene expressionGO:00106081450.065
regulation of cell cycleGO:00517262910.064
organic substance catabolic processGO:19015753080.063
dna damage checkpointGO:0000077780.060
dna integrity checkpointGO:0031570810.059
photoreceptor cell differentiationGO:00465301700.058
regulation of mrna splicing via spliceosomeGO:0048024640.058
cellular catabolic processGO:00442483720.056
macromolecule catabolic processGO:00090571610.055
regulation of intracellular transportGO:0032386640.053
multi multicellular organism processGO:00447061230.051
regulation of intracellular protein transportGO:0033157460.050
multicellular organismal reproductive behaviorGO:00330571100.047
organophosphate metabolic processGO:00196371950.045
positive regulation of response to stimulusGO:00485843230.045
proteolysisGO:00065081920.045
regulation of growthGO:00400082330.045
actin cytoskeleton organizationGO:00300362060.044
regulation of localizationGO:00328792750.042
chromatin modificationGO:00165681470.041
nucleobase containing compound catabolic processGO:00346551650.040
alternative mrna splicing via spliceosomeGO:0000380600.040
response to light stimulusGO:00094161240.040
single organism biosynthetic processGO:00447112060.040
regulation of nucleocytoplasmic transportGO:0046822350.039
hematopoietic or lymphoid organ developmentGO:0048534570.039
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.039
nuclear transportGO:0051169720.039
regulation of molecular functionGO:00650092170.038
single organism nuclear importGO:1902593510.038
hemopoiesisGO:0030097460.037
regulation of mrna processingGO:0050684710.037
developmental growthGO:00485892800.035
agingGO:00075681430.034
Worm
adult behaviorGO:00305341370.034
compound eye photoreceptor cell differentiationGO:00017511400.034
positive regulation of molecular functionGO:00440931360.033
endocytosisGO:00068973100.033
cellular nitrogen compound catabolic processGO:00442701650.033
larval developmentGO:00021641040.032
Worm
cellular macromolecular complex assemblyGO:00346221530.032
vesicle mediated transportGO:00161923810.032
enzyme linked receptor protein signaling pathwayGO:00071671790.032
positive regulation of cellular biosynthetic processGO:00313283160.031
positive regulation of ras protein signal transductionGO:0046579430.031
modification dependent macromolecule catabolic processGO:0043632790.030
reproductive behaviorGO:00190981220.030
small molecule metabolic processGO:00442813050.030
stem cell maintenanceGO:0019827670.029
dendrite morphogenesisGO:00488131990.029
positive regulation of signalingGO:00230562430.029
regulation of protein metabolic processGO:00512462560.028
regulation of protein transportGO:0051223570.027
aromatic compound catabolic processGO:00194391660.027
phagocytosisGO:00069092150.026
adult locomotory behaviorGO:0008344760.026
regulation of cellular protein metabolic processGO:00322682430.025
regulation of catabolic processGO:00098941700.024
negative regulation of biosynthetic processGO:00098902770.023
multi organism behaviorGO:00517051750.023
positive regulation of macromolecule metabolic processGO:00106044050.022
microtubule organizing center organizationGO:00310231680.022
regulation of mrna metabolic processGO:1903311720.021
multi organism reproductive behaviorGO:00447051210.021
regulation of establishment of protein localizationGO:0070201610.021
rna splicingGO:0008380830.021
organic substance transportGO:00717022570.021
regulation of translationGO:0006417560.021
positive regulation of macromolecule biosynthetic processGO:00105572830.021
regulation of catalytic activityGO:00507901850.021
negative regulation of gene expressionGO:00106293870.021
positive regulation of mapk cascadeGO:0043410630.020
positive regulation of intracellular signal transductionGO:19025331160.020
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.020
spermatid developmentGO:0007286980.020
eye photoreceptor cell differentiationGO:00017541450.020
regulation of cytoplasmic transportGO:1903649470.020
posttranscriptional gene silencing by rnaGO:0035194450.020
terminal cell fate specification open tracheal systemGO:003515440.020
establishment of localization in cellGO:00516494020.020
positive regulation of phosphate metabolic processGO:00459371390.019
positive regulation of proteolysisGO:0045862520.019
positive regulation of cell communicationGO:00106472500.019
single organism catabolic processGO:00447122280.019
regulation of cellular catabolic processGO:00313291570.019
organic cyclic compound catabolic processGO:19013611680.019
regulation of protein localizationGO:0032880760.019
regulation of cytoskeleton organizationGO:0051493890.019
compound eye developmentGO:00487493070.018
protein localizationGO:00081042840.018
negative regulation of cellular metabolic processGO:00313243820.018
negative regulation of phosphatase activityGO:001092330.018
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.018
positive regulation of epidermal growth factor activated receptor activityGO:004574110.018
mitotic sister chromatid segregationGO:0000070870.018
negative regulation of nucleobase containing compound metabolic processGO:00459342610.018
brain developmentGO:00074201200.018
mrna metabolic processGO:00160711240.017
regulation of protein catabolic processGO:0042176550.017
negative regulation of nucleic acid templated transcriptionGO:19035072400.017
eye developmentGO:00016543230.016
positive regulation of cellular component biogenesisGO:0044089800.016
mrna polyadenylationGO:0006378110.016
regulation of neuron differentiationGO:00456641030.016
negative regulation of protein bindingGO:003209110.016
negative regulation of developmental processGO:00510932010.016
mitotic nuclear divisionGO:00070672130.015
positive regulation of phosphorus metabolic processGO:00105621390.015
positive regulation of rna metabolic processGO:00512542710.015
positive regulation of signal transductionGO:00099672230.015
cellular response to chemical stimulusGO:00708871990.015
positive regulation of catalytic activityGO:00430851180.015
negative regulation of necrotic cell deathGO:006054710.014
positive regulation of protein complex assemblyGO:0031334220.014
cell recognitionGO:00080371020.014
regulation of transportGO:00510491810.014
nucleoside catabolic processGO:00091641120.014
cellular macromolecule localizationGO:00707272200.014
renal tubule developmentGO:0061326640.014
regulation of proteolysisGO:0030162870.014
nucleoside metabolic processGO:00091161270.014
sister chromatid segregationGO:0000819920.014
negative regulation of cellular biosynthetic processGO:00313272770.013
transcription from rna polymerase ii promoterGO:00063663680.013
cellular protein localizationGO:00346131600.013
rna splicing via transesterification reactionsGO:0000375730.013
cell fate specificationGO:0001708710.013
regulation of cellular component biogenesisGO:00440872010.013
dephosphorylationGO:0016311510.013
appendage morphogenesisGO:00351073970.013
regulation of meiosisGO:004002030.013
positive regulation of nucleobase containing compound metabolic processGO:00459353320.013
positive regulation of catabolic processGO:00098961050.013
protein catabolic processGO:00301631010.013
cellular protein complex assemblyGO:0043623710.013
ovipositionGO:0018991190.013
nucleobase containing small molecule metabolic processGO:00550861740.012
regulation of intracellular signal transductionGO:19025312360.012
regulation of hydrolase activityGO:0051336970.012
phosphorylation of rna polymerase ii c terminal domainGO:007081610.012
negative regulation of cellular protein metabolic processGO:0032269850.012
negative regulation of cell differentiationGO:00455961430.012
organelle inheritanceGO:004830820.012
ubiquitin dependent protein catabolic processGO:0006511780.012
mitochondrial membrane organizationGO:000700630.012
photoreceptor cell developmentGO:0042461960.012
negative regulation of mitotic cell cycleGO:00459301090.012
regulation of rna splicingGO:0043484690.012
positive regulation of gene expressionGO:00106282900.012
response to organic substanceGO:00100332840.012
posttranscriptional gene silencingGO:0016441460.012
spermatid differentiationGO:00485151140.011
response to radiationGO:00093141550.011
ras protein signal transductionGO:0007265880.011
axon developmentGO:00615642970.011
smoothened signaling pathwayGO:0007224490.011
rhythmic processGO:00485111060.011
regulation of hemocyte proliferationGO:0035206370.011
gonad developmentGO:0008406500.011
Worm
protein targetingGO:0006605640.011
negative regulation of intrinsic apoptotic signaling pathwayGO:200124310.011
negative regulation of nitrogen compound metabolic processGO:00511722650.011
regulation of alternative mrna splicing via spliceosomeGO:0000381600.010
positive regulation of hydrolase activityGO:0051345780.010
gland developmentGO:00487321910.010
ribonucleotide catabolic processGO:00092611090.010
gene silencing by rnaGO:0031047570.010
spindle organizationGO:00070512530.010
regulation of developmental growthGO:00486381740.010
regulation of phosphate metabolic processGO:00192202100.010
regulation of cell shapeGO:00083601130.010
axis specificationGO:00097981670.010
regulation of phosphorus metabolic processGO:00511742100.010
single organism intracellular transportGO:19025822070.010
regulation of protein export from nucleusGO:004682530.010
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377730.010

l(2)NC136 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.011
benign neoplasmDOID:006007200.011