Drosophila melanogaster

25 known processes

Npc2e (Dmel_CG31410)

Niemann-Pick type C-2e

(Aliases: CG31410,npc2e,CG3928,Dmel\CG31410)

Npc2e biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
organonitrogen compound metabolic processGO:19015643180.045
small molecule metabolic processGO:00442813050.043
Fly
cell cell signaling involved in cell fate commitmentGO:00451682100.036
response to abiotic stimulusGO:00096283410.035
catabolic processGO:00090564090.035
body morphogenesisGO:001017120.032
cellular catabolic processGO:00442483720.032
appendage developmentGO:00487364010.030
vesicle mediated transportGO:00161923810.030
regionalizationGO:00030024160.030
carboxylic acid metabolic processGO:0019752920.029
appendage morphogenesisGO:00351073970.029
oxoacid metabolic processGO:00434361030.029
organic substance catabolic processGO:19015753080.029
wing disc morphogenesisGO:00074723440.029
lateral inhibitionGO:00463312060.029
imaginal disc derived appendage morphogenesisGO:00351143950.028
protein modification processGO:00362114380.028
defense responseGO:00069523000.028
imaginal disc derived appendage developmentGO:00487373990.028
single organism biosynthetic processGO:00447112060.028
Fly
organic acid metabolic processGO:00060821030.028
post embryonic appendage morphogenesisGO:00351203850.028
positive regulation of response to stimulusGO:00485843230.027
imaginal disc derived wing morphogenesisGO:00074763370.026
cellular amino acid metabolic processGO:0006520610.026
neurological system processGO:00508773580.026
phagocytosisGO:00069092150.026
negative regulation of gene expressionGO:00106293870.025
negative regulation of cellular metabolic processGO:00313243820.025
camera type eye developmentGO:004301040.025
response to lipopolysaccharideGO:003249640.025
single organism behaviorGO:00447083910.025
regulation of multicellular organismal developmentGO:20000264140.025
benzene containing compound metabolic processGO:004253730.025
xenobiotic catabolic processGO:004217810.024
cellular protein modification processGO:00064644380.024
endocytosisGO:00068973100.024
single organism catabolic processGO:00447122280.024
nuclear divisionGO:00002803320.024
response to other organismGO:00517072930.023
intracellular signal transductionGO:00355563000.023
positive regulation of nitrogen compound metabolic processGO:00511733540.023
epithelial cell developmentGO:00020642740.023
forebrain developmentGO:003090020.023
regulation of cellular amine metabolic processGO:003323830.023
positive regulation of cell communicationGO:00106472500.022
regulation of localizationGO:00328792750.022
negative regulation of nitrogen compound metabolic processGO:00511722650.022
activation of innate immune responseGO:000221840.022
carbohydrate derivative metabolic processGO:19011352170.022
response to biotic stimulusGO:00096072940.022
growthGO:00400073590.022
hormone catabolic processGO:004244730.022
positive regulation of macromolecule metabolic processGO:00106044050.022
positive regulation of cellular biosynthetic processGO:00313283160.022
gland developmentGO:00487321910.021
transcription from rna polymerase ii promoterGO:00063663680.021
l amino acid importGO:004309220.021
steroid catabolic processGO:000670610.021
response to organic substanceGO:00100332840.021
organelle fissionGO:00482853400.021
positive regulation of nucleobase containing compound metabolic processGO:00459353320.021
epithelial cell differentiationGO:00308553220.021
immune system processGO:00023763470.020
Fly
compound eye developmentGO:00487493070.020
proteolysisGO:00065081920.020
positive regulation of signal transductionGO:00099672230.020
establishment of localization in cellGO:00516494020.020
regulation of cellular ketone metabolic processGO:001056530.020
taxisGO:00423303040.020
positive regulation of signalingGO:00230562430.020
cell deathGO:00082192790.020
adult behaviorGO:00305341370.020
developmental growthGO:00485892800.020
phosphorylationGO:00163102940.020
salivary gland developmentGO:00074311620.020
cellular response to ethanolGO:007136140.020
eye developmentGO:00016543230.020
sterol homeostasisGO:005509240.020
Fly
regulation of cell cycleGO:00517262910.020
columnar cuboidal epithelial cell developmentGO:00020662490.020
regulation of cellular amino acid metabolic processGO:000652100.020
tissue morphogenesisGO:00487292970.020
cellular ketone metabolic processGO:0042180240.019
Fly
columnar cuboidal epithelial cell differentiationGO:00020652560.019
kidney developmentGO:000182230.019
morphogenesis of an epitheliumGO:00020092760.019
defense response to other organismGO:00985422250.019
amine metabolic processGO:0009308120.019
organic substance transportGO:00717022570.019
Fly
cholesterol homeostasisGO:004263230.019
deathGO:00162652840.019
negative regulation of macromolecule biosynthetic processGO:00105582700.019
response to oxygen containing compoundGO:19017002000.019
negative regulation of signal transductionGO:00099682060.019
gland morphogenesisGO:00226121450.019
negative regulation of nucleic acid templated transcriptionGO:19035072400.019
response to external biotic stimulusGO:00432072930.019
regulation of intracellular signal transductionGO:19025312360.019
immune response activating signal transductionGO:000275720.019
positive regulation of nucleic acid templated transcriptionGO:19035082660.018
connective tissue developmentGO:006144830.018
regulation of cell differentiationGO:00455953020.018
homeostatic processGO:00425921990.018
Fly
negative regulation of cell communicationGO:00106482230.018
cellular amine metabolic processGO:0044106120.018
exocrine system developmentGO:00352721620.018
salivary gland morphogenesisGO:00074351450.018
cellular component assembly involved in morphogenesisGO:00109271510.018
negative regulation of biosynthetic processGO:00098902770.018
ovarian follicle cell developmentGO:00307072480.018
telencephalon developmentGO:002153720.018
compound eye morphogenesisGO:00017452490.018
negative regulation of cellular biosynthetic processGO:00313272770.018
regulation of molecular functionGO:00650092170.018
aromatic compound catabolic processGO:00194391660.018
positive regulation of rna biosynthetic processGO:19026802660.018
positive regulation of macromolecule biosynthetic processGO:00105572830.018
positive regulation of cell motilityGO:200014730.018
protein localizationGO:00081042840.018
l glutamate importGO:005193810.017
segmentationGO:00352822070.017
positive regulation of cell migrationGO:003033520.017
cell proliferationGO:00082832990.017
positive regulation of biosynthetic processGO:00098913160.017
macromolecule catabolic processGO:00090571610.017
regulation of transcription from rna polymerase ii promoterGO:00063573780.017
regulation of epithelial cell proliferationGO:005067840.017
ion transportGO:00068111450.017
heterocycle catabolic processGO:00467001660.017
regulation of phosphorus metabolic processGO:00511742100.017
negative regulation of signalingGO:00230572190.017
eye morphogenesisGO:00485922600.017
response to monosaccharideGO:003428440.017
positive regulation of gene expressionGO:00106282900.017
programmed cell deathGO:00125012570.017
regulation of immune system processGO:00026821760.017
androgen metabolic processGO:000820910.017
organophosphate metabolic processGO:00196371950.017
positive regulation of rna metabolic processGO:00512542710.017
sensory organ morphogenesisGO:00905962600.017
organic cyclic compound catabolic processGO:19013611680.017
developmental programmed cell deathGO:00106231380.017
sensory perceptionGO:00076001960.017
immune responseGO:00069552460.017
Fly
vitamin metabolic processGO:000676620.016
matingGO:00076181200.016
negative regulation of response to stimulusGO:00485852580.016
negative regulation of rna metabolic processGO:00512532510.016
positive regulation of transcription dna templatedGO:00458932660.016
tube developmentGO:00352952440.016
multi organism behaviorGO:00517051750.016
response to hexoseGO:000974630.016
negative regulation of rna biosynthetic processGO:19026792400.016
negative regulation of developmental processGO:00510932010.016
open tracheal system developmentGO:00074242040.016
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.016
response to organophosphorusGO:004668320.016
intracellular transportGO:00469072280.016
response to glucoseGO:000974920.016
negative regulation of nucleobase containing compound metabolic processGO:00459342610.016
detection of stimulusGO:00516061560.016
estrogen metabolic processGO:000821010.016
response to radiationGO:00093141550.016
fat soluble vitamin metabolic processGO:000677510.016
limb developmentGO:006017310.016
chromosome organizationGO:00512763600.016
regulation of cellular component biogenesisGO:00440872010.016
regulation of cellular protein metabolic processGO:00322682430.016
cellular response to chemical stimulusGO:00708871990.015
synaptic transmissionGO:00072682880.015
regulation of transportGO:00510491810.015
respiratory system developmentGO:00605412130.015
regulation of protein metabolic processGO:00512462560.015
regulation of phosphate metabolic processGO:00192202100.015
regulation of catalytic activityGO:00507901850.015
chemotaxisGO:00069352490.015
negative regulation of transcription dna templatedGO:00458922370.015
response to nutrient levelsGO:00316671140.015
mitotic nuclear divisionGO:00070672130.015
nucleobase containing small molecule metabolic processGO:00550861740.015
small gtpase mediated signal transductionGO:0007264880.015
pigmentationGO:0043473750.015
cellular macromolecule catabolic processGO:00442651360.015
immune response regulating signaling pathwayGO:000276420.015
cellular response to dna damage stimulusGO:00069742230.015
protein hydroxylationGO:001812610.015
cell cycle phase transitionGO:00447701400.015
mitotic cell cycle phase transitionGO:00447721380.015
cellular nitrogen compound catabolic processGO:00442701650.015
camera type eye morphogenesisGO:004859320.015
retina development in camera type eyeGO:006004140.015
response to bacteriumGO:00096171980.015
dorsal ventral pattern formationGO:00099531330.015
regulation of multi organism processGO:00439001310.015
regulation of response to stressGO:00801342000.015
hindbrain developmentGO:003090220.015
neuropeptide signaling pathwayGO:0007218450.015
regulation of catabolic processGO:00098941700.014
regulation of developmental growthGO:00486381740.014
regulation of mitotic cell cycleGO:00073461900.014
single organism intracellular transportGO:19025822070.014
regulation of cellular catabolic processGO:00313291570.014
negative regulation of multicellular organismal processGO:00512411420.014
lipid metabolic processGO:00066291210.014
Fly
regulation of cell developmentGO:00602842150.014
enzyme linked receptor protein signaling pathwayGO:00071671790.014
developmental maturationGO:00217001720.014
peptide metabolic processGO:0006518800.014
eggshell formationGO:00307031050.014
mesenchymal cell differentiationGO:004876210.014
nephron developmentGO:007200630.014
regulation of cell cycle phase transitionGO:19019871300.014
ras protein signal transductionGO:0007265880.014
neutral lipid biosynthetic processGO:004646020.014
defense response to bacteriumGO:00427421780.014
regulation of cell cycle processGO:00105641810.014
cellular amide metabolic processGO:0043603800.014
nucleoside phosphate metabolic processGO:00067531620.014
chromosome segregationGO:00070591570.014
tube morphogenesisGO:00352391910.014
blastoderm segmentationGO:00073501590.014
gene silencingGO:00164581380.014
mesenchymal cell developmentGO:001403110.014
embryonic pattern specificationGO:00098801740.014
regulation of mitotic cell cycle phase transitionGO:19019901300.014
neuron projection guidanceGO:00974852410.014
axis specificationGO:00097981670.014
organelle assemblyGO:00709251980.014
phosphate ion transportGO:000681740.013
vitamin biosynthetic processGO:000911010.013
organonitrogen compound biosynthetic processGO:19015661170.013
nucleobase containing compound catabolic processGO:00346551650.013
rna processingGO:00063961470.013
positive regulation of cellular amine metabolic processGO:003324000.013
regulation of epithelial cell differentiationGO:003085640.013
triglyceride catabolic processGO:001943330.013
regulation of cell deathGO:00109411730.013
developmental pigmentationGO:0048066680.013
cellular macromolecule localizationGO:00707272200.013
transmembrane transportGO:00550851390.013
cellular response to molecule of bacterial originGO:007121930.013
response to light stimulusGO:00094161240.013
leg disc developmentGO:0035218920.013
spermatogenesisGO:00072832000.013
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.013
kidney epithelium developmentGO:007207330.013
multicellular organismal agingGO:00102591400.013
chorion containing eggshell formationGO:00073041050.013
regulation of synapse structure and activityGO:00508031280.013
acylglycerol biosynthetic processGO:004646320.013
male gamete generationGO:00482322010.013
cell divisionGO:00513012480.013
regulation of nervous system developmentGO:00519602480.013
anion homeostasisGO:005508130.013
macromolecular complex assemblyGO:00650032560.013
negative regulation of cell differentiationGO:00455961430.013
carbohydrate metabolic processGO:0005975820.013
humoral immune responseGO:00069591170.013
Fly
antimicrobial humoral responseGO:0019730990.013
glycerolipid catabolic processGO:004650330.013
cell motilityGO:00488702510.013
sensory perception of chemical stimulusGO:00076061160.013
regulation of anatomical structure morphogenesisGO:00226032420.013
actin cytoskeleton organizationGO:00300362060.013
triglyceride biosynthetic processGO:001943220.013
positive regulation of cellular amino acid metabolic processGO:004576400.013
locomotory behaviorGO:00076261760.013
purine nucleotide metabolic processGO:00061631460.013
ion transmembrane transportGO:00342201220.013
response to copper ionGO:004668840.013
nephron epithelium developmentGO:007200930.013
posttranscriptional regulation of gene expressionGO:00106081450.013
cellular response to lipopolysaccharideGO:007122230.013
chaeta developmentGO:0022416970.013
skeletal muscle fiber developmentGO:004874130.013
innate immune responseGO:00450871440.013
Fly
nucleotide metabolic processGO:00091171610.013
actin filament based processGO:00300292200.013
fat soluble vitamin biosynthetic processGO:004236210.013
limb morphogenesisGO:003510810.012
purine ribonucleotide metabolic processGO:00091501450.012
protein transportGO:00150311550.012
negative regulation of cell cycle processGO:00109481090.012
regulation of gene expression epigeneticGO:00400291280.012
kidney morphogenesisGO:006099330.012
purine containing compound metabolic processGO:00725211550.012
regulation of notch signaling pathwayGO:00085931000.012
axon developmentGO:00615642970.012
nephron tubule developmentGO:007208030.012
regulation of immune responseGO:00507761180.012
monocarboxylic acid transportGO:001571830.012
axon guidanceGO:00074112330.012
spindle organizationGO:00070512530.012
pattern recognition receptor signaling pathwayGO:000222120.012
apoptotic processGO:00069151590.012
salivary gland cell autophagic cell deathGO:0035071830.012
regulation of programmed cell deathGO:00430671520.012
sodium dependent phosphate transportGO:004434120.012
photoreceptor cell differentiationGO:00465301700.012
dendrite developmentGO:00163582040.012
regulation of response to external stimulusGO:00321011150.012
tissue deathGO:00162711020.012
chromatin organizationGO:00063252070.012
cellular protein localizationGO:00346131600.012
single organism cellular localizationGO:19025801800.012
pigment metabolic processGO:0042440840.012
histolysisGO:00075591020.012
establishment of protein localizationGO:00451841630.012
ethanolamine containing compound metabolic processGO:004243940.012
organonitrogen compound catabolic processGO:19015651280.012
positive regulation of catabolic processGO:00098961050.012
purine ribonucleoside metabolic processGO:00461281270.012
detection of abiotic stimulusGO:0009582660.012
notch signaling pathwayGO:00072191200.012
signal transduction by phosphorylationGO:00230141070.012
peptidyl amino acid modificationGO:00181931050.012
regulation of organelle organizationGO:00330431960.012
cation transportGO:00068121100.012
synapse organizationGO:00508081960.012
imaginal disc pattern formationGO:0007447910.012
autophagic cell deathGO:0048102830.012
sensory perception of salty tasteGO:005091430.012
cell migrationGO:00164772380.012
ribonucleotide metabolic processGO:00092591450.012
sister chromatid segregationGO:0000819920.012
protein phosphorylationGO:00064681690.012
positive regulation of phosphorus metabolic processGO:00105621390.012
cytoplasmic transportGO:00164821300.012
mrna metabolic processGO:00160711240.012
central nervous system developmentGO:00074172010.012
axonogenesisGO:00074092900.012
positive regulation of lipid storageGO:001088440.012
cellular response to hexose stimulusGO:007133110.012
hematopoietic progenitor cell differentiationGO:000224410.012
positive regulation of catalytic activityGO:00430851180.012
innate immune response activating signal transductionGO:000275820.012
sensory perception of painGO:001923340.012
salt aversionGO:003519930.012
regulation of i kappab kinase nf kappab signalingGO:004312220.012
nucleoside metabolic processGO:00091161270.012
positive regulation of multicellular organismal processGO:00512401430.012
positive regulation of intracellular signal transductionGO:19025331160.012
acetate ester metabolic processGO:190061920.011
polyol biosynthetic processGO:004617330.011
response to extracellular stimulusGO:00099911160.011
establishment or maintenance of cell polarityGO:00071631670.011
negative regulation of cell cycleGO:00457861160.011
response to endogenous stimulusGO:00097191190.011
cellular response to carbohydrate stimulusGO:007132240.011
localization of cellGO:00516742570.011
salivary gland histolysisGO:0035070880.011
imaginal disc derived leg morphogenesisGO:0007480800.011
organophosphate catabolic processGO:00464341120.011
regulation of cell substrate adhesionGO:001081020.011
somatic muscle developmentGO:0007525660.011
multi multicellular organism processGO:00447061230.011
regulation of lipid transportGO:003236830.011
sensory perception of smellGO:0007608800.011
acetylcholine metabolic processGO:000829120.011
dendrite morphogenesisGO:00488131990.011
cellular response to biotic stimulusGO:007121640.011
pigment metabolic process involved in pigmentationGO:0043474330.011
ribonucleoside metabolic processGO:00091191270.011
regulation of cellular response to stressGO:0080135890.011
spinal cord developmentGO:002151010.011
embryonic development via the syncytial blastodermGO:00017001480.011
eye photoreceptor cell differentiationGO:00017541450.011
response to painGO:004826530.011
regulation of phosphorylationGO:00423251470.011
mitotic dna integrity checkpointGO:0044774750.011
cuticle developmentGO:0042335860.011
anterior posterior axis specification embryoGO:00085951030.011
cell maturationGO:00484691440.011
synapse assemblyGO:00074161430.011
molting cycle chitin based cuticleGO:0007591560.011
cell cycle checkpointGO:0000075950.011
compound eye photoreceptor cell differentiationGO:00017511400.011
wnt signaling pathwayGO:0016055980.011
establishment of tissue polarityGO:0007164870.011
pyridine containing compound metabolic processGO:007252430.011
positive regulation of peptidyl tyrosine phosphorylationGO:005073140.011
cellular response to organic substanceGO:00713101320.011
protein catabolic processGO:00301631010.011
mitotic spindle organizationGO:00070522200.011
cellular homeostasisGO:0019725800.011
wound healingGO:0042060750.011
Fly
regulation of cellular localizationGO:00603411360.011
detection of external stimulusGO:0009581660.011
eye pigmentationGO:0048069430.011
secondary metabolic processGO:0019748750.011
membrane depolarizationGO:005189940.011
cellular lipid metabolic processGO:0044255830.011
cellular response to monosaccharide stimulusGO:007132620.011
response to alcoholGO:0097305950.011
regulation of response to biotic stimulusGO:0002831630.011
ameboidal type cell migrationGO:00016671510.011
regulation of synapse assemblyGO:0051963940.011
photoreceptor cell developmentGO:0042461960.011
regulation of growthGO:00400082330.011
imaginal disc derived wing vein specificationGO:0007474480.011
autophagyGO:00069141080.011
leg disc morphogenesisGO:0007478800.011
anterior posterior pattern specificationGO:00099521360.011
positive regulation of phosphate metabolic processGO:00459371390.011
eggshell chorion assemblyGO:0007306660.011
purine nucleoside metabolic processGO:00422781270.010
glutathione metabolic processGO:0006749370.010
acylglycerol catabolic processGO:004646430.010
mapk cascadeGO:00001651070.010
cholesterol transportGO:003030120.010
negative regulation of nervous system developmentGO:0051961920.010
long chain fatty acid metabolic processGO:000167630.010
carbohydrate derivative catabolic processGO:19011361180.010
digestive tract developmentGO:00485651490.010
regulation of apoptotic processGO:00429811300.010
oxidoreduction coenzyme metabolic processGO:000673320.010
positive regulation of molecular functionGO:00440931360.010
positive regulation of transportGO:0051050920.010
digestive tract morphogenesisGO:00485461270.010
cell cycle arrestGO:000705040.010
nicotinamide nucleotide metabolic processGO:004649620.010
regulation of mapk cascadeGO:0043408920.010
endomembrane system organizationGO:00102561190.010
proteolysis involved in cellular protein catabolic processGO:0051603830.010
tripartite regional subdivisionGO:00073511030.010
cellular modified amino acid metabolic processGO:0006575450.010
single organism carbohydrate metabolic processGO:0044723720.010
dna integrity checkpointGO:0031570810.010
nucleoside phosphate catabolic processGO:19012921100.010
phosphatidic acid metabolic processGO:004647310.010
regulation of synapse organizationGO:00508071100.010
response to ethanolGO:0045471590.010
mitotic sister chromatid segregationGO:0000070870.010
behavioral response to painGO:004826630.010
drinking behaviorGO:004275620.010
protein complex biogenesisGO:00702712010.010
mrna processingGO:00063971040.010
g protein coupled receptor signaling pathwayGO:00071861360.010
ribose phosphate metabolic processGO:00196931450.010
organelle localizationGO:00516401480.010
ribonucleoside catabolic processGO:00424541120.010
inter male aggressive behaviorGO:0002121600.010
purine nucleotide catabolic processGO:00061951090.010
embryonic morphogenesisGO:00485982060.010
positive regulation of developmental processGO:00510941430.010
sulfur compound metabolic processGO:0006790590.010
extrinsic apoptotic signaling pathwayGO:009719110.010
muscle structure developmentGO:00610612240.010
protein complex assemblyGO:00064612000.010
regulation of hydrolase activityGO:0051336970.010
protein processingGO:0016485680.010

Npc2e disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.036
nervous system diseaseDOID:86300.019
disease of metabolismDOID:001466700.018
inherited metabolic disorderDOID:65500.018
cardiovascular system diseaseDOID:128700.016
disease of cellular proliferationDOID:1456600.013
urinary system diseaseDOID:1800.013
sensory system diseaseDOID:005015500.013
musculoskeletal system diseaseDOID:1700.013
eye diseaseDOID:561400.012
eye and adnexa diseaseDOID:149200.012
glucose metabolism diseaseDOID:419400.012
type 2 diabetes mellitusDOID:935200.012
acquired metabolic diseaseDOID:006015800.012
diabetes mellitusDOID:935100.012
carbohydrate metabolism diseaseDOID:005001300.012
kidney diseaseDOID:55700.012
artery diseaseDOID:005082800.011
vascular diseaseDOID:17800.011
hypertensionDOID:1076300.011
organ system cancerDOID:005068600.011
cancerDOID:16200.011