Drosophila melanogaster

41 known processes

Npc1b (Dmel_CG12092)

Niemann-Pick type C-1b

(Aliases: 151,dncp1b,Dmel\CG12092,CG12092,l(1)19Ec,NPC1b,l(1)R-9-28,l152,lt2-14a,R9-28,Q256,lN5,npc1b,l(1)2-3,AF2/19,4,7,Dmel_CG11233,R-9-28,l151)

Npc1b biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of nitrogen compound metabolic processGO:00511733540.295
cuticle developmentGO:0042335860.250
positive regulation of macromolecule biosynthetic processGO:00105572830.153
protein localizationGO:00081042840.151
foregut morphogenesisGO:0007440100.129
intracellular transportGO:00469072280.128
positive regulation of gene expressionGO:00106282900.127
axis specificationGO:00097981670.121
innate immune responseGO:00450871440.102
cytoplasmic transportGO:00164821300.087
nuclear divisionGO:00002803320.085
single organism membrane organizationGO:0044802930.084
embryonic pattern specificationGO:00098801740.081
positive regulation of biosynthetic processGO:00098913160.078
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.078
embryo development ending in birth or egg hatchingGO:00097921520.077
molting cycle processGO:0022404290.075
secondary metabolic processGO:0019748750.074
positive regulation of nucleobase containing compound metabolic processGO:00459353320.072
digestive tract developmentGO:00485651490.072
positive regulation of cellular biosynthetic processGO:00313283160.071
membrane organizationGO:00610241120.069
zygotic determination of anterior posterior axis embryoGO:0007354270.064
molting cycle chitin based cuticleGO:0007591560.061
nephron tubule morphogenesisGO:007207830.058
negative regulation of gene expressionGO:00106293870.057
nephron epithelium developmentGO:007200930.054
nephron epithelium morphogenesisGO:007208830.054
periodic partitioningGO:0007365290.054
spindle organizationGO:00070512530.053
cell cycle phase transitionGO:00447701400.053
small molecule metabolic processGO:00442813050.052
embryonic morphogenesisGO:00485982060.052
rna processingGO:00063961470.052
cellular protein localizationGO:00346131600.051
macromolecular complex assemblyGO:00650032560.051
kidney developmentGO:000182230.051
blastoderm segmentationGO:00073501590.049
larval behaviorGO:0030537420.049
programmed cell deathGO:00125012570.048
digestive system developmentGO:00551231490.048
single organism intracellular transportGO:19025822070.046
regulation of notch signaling pathwayGO:00085931000.044
morphogenesis of embryonic epitheliumGO:0016331940.044
gastrulation with mouth forming firstGO:0001703360.044
positive regulation of nucleic acid templated transcriptionGO:19035082660.044
nephron tubule developmentGO:007208030.044
kidney epithelium developmentGO:007207330.044
response to organic substanceGO:00100332840.043
terminal region determinationGO:0007362250.042
protein modification processGO:00362114380.042
defense responseGO:00069523000.041
ecdysone biosynthetic processGO:000669790.041
sensory organ morphogenesisGO:00905962600.041
intracellular protein transportGO:00068861040.041
mitotic nuclear divisionGO:00070672130.040
cellular macromolecule localizationGO:00707272200.040
intracellular signal transductionGO:00355563000.040
segment polarity determinationGO:0007367250.040
organic substance transportGO:00717022570.038
eye developmentGO:00016543230.038
regulation of embryonic pattern specificationGO:1902875270.038
imaginal disc derived leg segmentationGO:0036011260.037
regulation of mitotic cell cycleGO:00073461900.037
positive regulation of transcription dna templatedGO:00458932660.036
negative regulation of cellular metabolic processGO:00313243820.035
organic substance catabolic processGO:19015753080.035
cell cell signaling involved in cell fate commitmentGO:00451682100.035
skin developmentGO:0043588650.034
posttranscriptional regulation of gene expressionGO:00106081450.034
columnar cuboidal epithelial cell developmentGO:00020662490.034
single organism biosynthetic processGO:00447112060.034
response to organophosphorusGO:004668320.034
vesicle mediated transportGO:00161923810.033
sterol biosynthetic processGO:001612690.033
nephron developmentGO:007200630.033
response to external biotic stimulusGO:00432072930.032
regulation of localizationGO:00328792750.032
wing disc morphogenesisGO:00074723440.032
protein targetingGO:0006605640.032
regulation of anatomical structure morphogenesisGO:00226032420.032
cellular ketone metabolic processGO:0042180240.032
organelle fissionGO:00482853400.031
ovarian follicle cell developmentGO:00307072480.031
establishment of protein localizationGO:00451841630.031
negative regulation of cell cycle processGO:00109481090.031
mesoderm developmentGO:0007498780.031
positive regulation of rna biosynthetic processGO:19026802660.031
neuromuscular junction developmentGO:00075281490.031
response to extracellular stimulusGO:00099911160.030
segmentationGO:00352822070.030
chemical homeostasisGO:0048878920.030
steroid metabolic processGO:0008202200.030
regionalizationGO:00030024160.030
protein complex biogenesisGO:00702712010.030
chitin based cuticle developmentGO:0040003490.029
cellular protein modification processGO:00064644380.029
positive regulation of response to stimulusGO:00485843230.028
regulation of cell cycle processGO:00105641810.028
single organism behaviorGO:00447083910.028
regulation of programmed cell deathGO:00430671520.028
regulation of pole plasm oskar mrna localizationGO:0007317270.028
epithelial cell developmentGO:00020642740.028
positive regulation of rna metabolic processGO:00512542710.027
growthGO:00400073590.027
response to radiationGO:00093141550.027
epithelial cell differentiationGO:00308553220.026
deathGO:00162652840.026
cellular response to chemical stimulusGO:00708871990.026
endomembrane system organizationGO:00102561190.026
multicellular organism growthGO:0035264460.026
neurological system processGO:00508773580.026
endoderm formationGO:000170630.025
sterol metabolic processGO:0016125120.025
protein complex assemblyGO:00064612000.025
pigment metabolic processGO:0042440840.025
regulation of cellular component biogenesisGO:00440872010.025
nitrogen compound transportGO:0071705850.025
single organism cellular localizationGO:19025801800.025
mrna metabolic processGO:00160711240.025
steroid biosynthetic processGO:0006694160.025
endocytosisGO:00068973100.024
anterior posterior pattern specificationGO:00099521360.024
response to other organismGO:00517072930.024
posttranscriptional gene silencing by rnaGO:0035194450.024
pronuclear migrationGO:003504640.024
regulation of cell cycleGO:00517262910.024
hormone biosynthetic processGO:0042446200.024
response to oxygen containing compoundGO:19017002000.024
dna damage checkpointGO:0000077780.024
compound eye photoreceptor developmentGO:0042051780.023
nephron morphogenesisGO:007202830.023
steroid catabolic processGO:000670610.023
reproductive structure developmentGO:0048608740.023
phagocytosisGO:00069092150.023
organic cyclic compound catabolic processGO:19013611680.023
ras protein signal transductionGO:0007265880.023
oocyte developmentGO:00485991240.023
positive regulation of macromolecule metabolic processGO:00106044050.023
negative regulation of cellular biosynthetic processGO:00313272770.022
gastrulation involving germ band extensionGO:0010004360.022
defense response to bacteriumGO:00427421780.022
larval developmentGO:00021641040.022
negative regulation of response to stimulusGO:00485852580.022
meiotic nuclear divisionGO:00071261510.022
asymmetric protein localizationGO:0008105330.022
male gamete generationGO:00482322010.022
lateral inhibitionGO:00463312060.021
reproductive system developmentGO:0061458740.021
eye morphogenesisGO:00485922600.021
gene silencing by rnaGO:0031047570.021
establishment of localization in cellGO:00516494020.021
imaginal disc derived leg morphogenesisGO:0007480800.021
transmembrane transportGO:00550851390.021
regulation of synaptic growth at neuromuscular junctionGO:0008582890.021
protein transportGO:00150311550.021
kidney morphogenesisGO:006099330.021
organelle assemblyGO:00709251980.020
actin filament based processGO:00300292200.020
response to abiotic stimulusGO:00096283410.020
photoreceptor cell developmentGO:0042461960.020
spermatogenesisGO:00072832000.020
anion homeostasisGO:005508130.020
eye photoreceptor cell differentiationGO:00017541450.020
positive regulation of signalingGO:00230562430.020
regulation of cytoskeleton organizationGO:0051493890.020
embryonic foregut morphogenesisGO:004861730.020
imaginal disc derived appendage morphogenesisGO:00351143950.020
nucleocytoplasmic transportGO:0006913720.019
regulation of synapse structure and activityGO:00508031280.019
oxidation reduction processGO:00551141230.019
oocyte differentiationGO:00099941450.019
locomotory behaviorGO:00076261760.019
limb morphogenesisGO:003510810.019
positive regulation of cell migrationGO:003033520.019
catabolic processGO:00090564090.019
sensory perceptionGO:00076001960.019
peptidyl amino acid modificationGO:00181931050.019
positive regulation of signal transductionGO:00099672230.019
regulation of mrna metabolic processGO:1903311720.019
cellular catabolic processGO:00442483720.019
organonitrogen compound metabolic processGO:19015643180.018
response to monosaccharideGO:003428440.018
establishment or maintenance of cell polarityGO:00071631670.018
response to ecdysoneGO:0035075340.018
transcription from rna polymerase ii promoterGO:00063663680.018
heterocycle catabolic processGO:00467001660.018
tissue morphogenesisGO:00487292970.018
digestive tract morphogenesisGO:00485461270.018
regulation of apoptotic processGO:00429811300.017
photoreceptor cell differentiationGO:00465301700.017
synapse assemblyGO:00074161430.017
formation of anatomical boundaryGO:0048859370.017
organic hydroxy compound metabolic processGO:1901615830.017
homeostatic processGO:00425921990.017
small molecule biosynthetic processGO:0044283370.017
cellular response to organic substanceGO:00713101320.017
oxoacid metabolic processGO:00434361030.017
regulation of cell deathGO:00109411730.017
imaginal disc derived leg joint morphogenesisGO:0016348150.017
anterior posterior axis specification embryoGO:00085951030.017
regulation of multicellular organism growthGO:0040014400.017
positive regulation of jun kinase activityGO:004350740.016
establishment of organelle localizationGO:00516561220.016
translationGO:0006412690.016
mitotic sister chromatid segregationGO:0000070870.016
phenol containing compound metabolic processGO:0018958570.016
nephron tubule formationGO:007207930.016
cellular macromolecule catabolic processGO:00442651360.016
meiotic cell cycleGO:00513211710.016
regulation of cell maturationGO:1903429270.016
regulation of circadian rhythmGO:0042752490.016
cellular nitrogen compound catabolic processGO:00442701650.016
limb developmentGO:006017310.016
gland developmentGO:00487321910.016
determination of adult lifespanGO:00083401370.016
dorsal ventral pattern formationGO:00099531330.016
plasma membrane organizationGO:0007009260.016
defense response to other organismGO:00985422250.015
negative regulation of nitrogen compound metabolic processGO:00511722650.015
cellular protein complex assemblyGO:0043623710.015
gastrulationGO:0007369700.015
negative regulation of nucleic acid templated transcriptionGO:19035072400.015
cellular component assembly involved in morphogenesisGO:00109271510.015
apoptotic processGO:00069151590.015
chromosome segregationGO:00070591570.015
positive regulation of nuclear transcribed mrna poly a tail shorteningGO:006021340.015
nuclear transportGO:0051169720.015
regulation of synapse organizationGO:00508071100.015
sex differentiationGO:0007548810.015
lipid biosynthetic processGO:0008610460.015
regulation of catabolic processGO:00098941700.015
leg disc morphogenesisGO:0007478800.015
regulation of cellular protein metabolic processGO:00322682430.015
positive regulation of protein transportGO:0051222370.015
notch signaling pathwayGO:00072191200.015
response to biotic stimulusGO:00096072940.015
positive regulation of cell communicationGO:00106472500.015
multicellular organismal agingGO:00102591400.015
spermatid differentiationGO:00485151140.015
cell proliferationGO:00082832990.015
positive regulation of mrna 3 end processingGO:003144240.015
germarium derived egg chamber formationGO:00072931010.015
compound eye morphogenesisGO:00017452490.015
microtubule organizing center organizationGO:00310231680.015
agingGO:00075681430.015
oocyte constructionGO:00073081120.015
regulation of embryonic developmentGO:0045995680.015
response to temperature stimulusGO:00092661060.015
imaginal disc derived wing morphogenesisGO:00074763370.014
dorsal ventral pattern formation imaginal discGO:0007450510.014
regulation of gene expression epigeneticGO:00400291280.014
ketone biosynthetic processGO:0042181160.014
regulation of cellular amine metabolic processGO:003323830.014
positive regulation of molecular functionGO:00440931360.014
dna integrity checkpointGO:0031570810.014
nucleoside triphosphate catabolic processGO:00091431080.014
mitotic cell cycle phase transitionGO:00447721380.014
spermatid developmentGO:0007286980.014
receptor clusteringGO:004311330.013
negative regulation of cell communicationGO:00106482230.013
enteroendocrine cell differentiationGO:003588310.013
regulation of response to stressGO:00801342000.013
regulation of cell cycle phase transitionGO:19019871300.013
regulation of heart morphogenesisGO:200082630.013
rhythmic processGO:00485111060.013
ecdysteroid biosynthetic processGO:0045456150.013
regulation of molecular functionGO:00650092170.013
developmental programmed cell deathGO:00106231380.013
muscle tissue developmentGO:0060537300.013
epidermis developmentGO:0008544650.013
cholesterol homeostasisGO:004263230.013
toll signaling pathwayGO:0008063250.013
mating behavior sex discriminationGO:004804770.013
regulation of small gtpase mediated signal transductionGO:0051056930.013
dorsal closureGO:0007391790.013
regulation of protein metabolic processGO:00512462560.013
regulation of intracellular signal transductionGO:19025312360.013
eye photoreceptor cell developmentGO:0042462810.013
regulation of nuclear transcribed mrna poly a tail shorteningGO:006021140.013
posttranscriptional gene silencingGO:0016441460.013
regulation of protein deacetylationGO:009031120.013
rna catabolic processGO:0006401370.013
negative regulation of mitotic cell cycleGO:00459301090.013
chemosensory behaviorGO:00076351060.013
maintenance of locationGO:0051235730.013
leg disc developmentGO:0035218920.013
establishment of protein localization to membraneGO:0090150110.013
axon guidanceGO:00074112330.013
regulation of rna splicingGO:0043484690.013
developmental growthGO:00485892800.013
mitochondrion organizationGO:0007005650.012
imaginal disc pattern formationGO:0007447910.012
membrane depolarizationGO:005189940.012
cellular response to ethanolGO:007136140.012
negative regulation of signal transductionGO:00099682060.012
rna 3 end processingGO:0031123450.012
regulation of mitotic cell cycle phase transitionGO:19019901300.012
matingGO:00076181200.012
embryonic axis specificationGO:00005781070.012
compound eye developmentGO:00487493070.012
centrosome organizationGO:00512971630.012
regulation of translationGO:0006417560.012
immune system processGO:00023763470.012
wing disc pattern formationGO:0035222660.012
apoptotic process involved in morphogenesisGO:006056130.012
response to nutrient levelsGO:00316671140.012
morphogenesis of an epitheliumGO:00020092760.012
establishment or maintenance of epithelial cell apical basal polarityGO:0045197240.012
regulation of anatomical structure sizeGO:00900661630.012
establishment or maintenance of polarity of follicular epitheliumGO:0016334260.012
regulation of epithelial cell differentiationGO:003085640.012
regulation of defense responseGO:00313471020.012
positive regulation of mrna metabolic processGO:190331350.012
positive regulation of catabolic processGO:00098961050.012
pole plasm assemblyGO:0007315610.012
protein palmitoylationGO:001834520.012
response to lipopolysaccharideGO:003249640.012
regulation of g1 s transition of mitotic cell cycleGO:2000045230.011
cellular amino acid metabolic processGO:0006520610.011
innate immune response activating signal transductionGO:000275820.011
regulation of ras protein signal transductionGO:0046578930.011
alcohol metabolic processGO:0006066250.011
appendage morphogenesisGO:00351073970.011
tube formationGO:0035148210.011
long chain fatty acid biosynthetic processGO:004275910.011
compound eye photoreceptor cell differentiationGO:00017511400.011
gene silencingGO:00164581380.011
ecdysis chitin based cuticleGO:001899080.011
body morphogenesisGO:001017120.011
carboxylic acid metabolic processGO:0019752920.011
mitotic cell cycle checkpointGO:0007093880.011
embryonic development via the syncytial blastodermGO:00017001480.011
negative regulation of developmental processGO:00510932010.011
response to unfolded proteinGO:000698690.011
autophagyGO:00069141080.011
amine metabolic processGO:0009308120.011
cell motilityGO:00488702510.011
cellular amine metabolic processGO:0044106120.011
substrate dependent cell migrationGO:000692930.011
ecdysone metabolic processGO:0008205110.011
regulation of developmental growthGO:00486381740.011
regulation of excitatory postsynaptic membrane potentialGO:006007930.011
negative regulation of mitotic cell cycle phase transitionGO:19019911030.011
rrna processingGO:000636430.011
lipid localizationGO:0010876540.010
camera type eye developmentGO:004301040.010
protein localization to organelleGO:0033365820.010
single organism catabolic processGO:00447122280.010
ecdysteroid metabolic processGO:0045455190.010
regulation of transportGO:00510491810.010
regulation of cell projection organizationGO:0031344920.010
regulation of synapse assemblyGO:0051963940.010
alcohol biosynthetic processGO:0046165140.010
ncrna metabolic processGO:0034660430.010
appendage segmentationGO:0035285260.010
immune response activating signal transductionGO:000275720.010
positive regulation of immune responseGO:0050778630.010
head segmentationGO:0035287130.010
regulation of cellular localizationGO:00603411360.010
regulation of protein transportGO:0051223570.010
mrna catabolic processGO:0006402330.010
regulation of cellular ketone metabolic processGO:001056530.010
establishment of protein localization to organelleGO:0072594620.010
small gtpase mediated signal transductionGO:0007264880.010
aromatic compound catabolic processGO:00194391660.010
nucleotide metabolic processGO:00091171610.010
signal releaseGO:0023061490.010
production of molecular mediator of immune responseGO:0002440460.010

Npc1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.030
disease of metabolismDOID:001466700.026
inherited metabolic disorderDOID:65500.015