IMP: Integrative Multi-species Prediction

Drosophila melanogaster

244 known processes

aPKC (Dmel_CG42783)

atypical protein kinase C

(Aliases: daPKC,Dmel_CG30475,PKCzeta,pkc-3,a-PKC,DaPKC,aPKC-zeta,2R-265-2,Dmel_CG10261,2R-141-24,CG42783,apkc,2R-69-30,Dmel\CG42783,aPKCzeta,CG30475,psu,2R-417-13,i,l(2)k06403,dapkc,CG10261,PKCl)

Entrez: 47594
FLYBASE: FBgn0261854
UniProtKB: A1Z9X0

Process Predictions
Disease Predictions

aPKC biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
oocyte differentiation	GO:0009994	145	1.000
oocyte construction	GO:0007308	112	1.000
pole plasm oskar mrna localization	GO:0045451	46	0.999
blastoderm segmentation	GO:0007350	159	0.999
tissue morphogenesis	GO:0048729	297	0.999
pole plasm mrna localization	GO:0019094	49	0.999
pole plasm assembly	GO:0007315	61	0.999
oocyte development	GO:0048599	124	0.999
pole plasm rna localization	GO:0007316	52	0.999
embryonic pattern specification	GO:0009880	174	0.997
morphogenesis of an epithelium	GO:0002009	276	0.993
anterior posterior axis specification embryo	GO:0008595	103	0.991
embryonic development via the syncytial blastoderm	GO:0001700	148	0.988
tripartite regional subdivision	GO:0007351	103	0.988
oocyte anterior posterior axis specification	GO:0007314	72	0.983
regionalization	GO:0003002	416	0.982
segmentation	GO:0035282	207	0.980
germarium derived egg chamber formation	GO:0007293	101	0.979
axis specification	GO:0009798	167	0.978
morphogenesis of embryonic epithelium	GO:0016331	94	0.972
germarium derived oocyte fate determination	GO:0007294	26	0.972
oocyte axis specification	GO:0007309	108	0.972
cellular macromolecule localization	GO:0070727	220	0.971
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.971
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.967
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.963
female germ line cyst formation	GO:0048135	42	0.943
regulation of dendrite development	GO:0050773	37	0.939
germarium derived female germ line cyst formation	GO:0030727	42	0.911
spermatid differentiation	GO:0048515	114	0.903
anterior posterior pattern specification	GO:0009952	136	0.884
cytoplasm organization	GO:0007028	64	0.840
anterior posterior axis specification	GO:0009948	109	0.822
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.820
regulation of dendrite morphogenesis	GO:0048814	28	0.819
tube morphogenesis	GO:0035239	191	0.805
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.801
regulation of nervous system development	GO:0051960	248	0.774
cellular protein localization	GO:0034613	160	0.768
regulation of cell development	GO:0060284	215	0.741
male gamete generation	GO:0048232	201	0.741
regulation of neurogenesis	GO:0050767	158	0.736
intracellular mrna localization	GO:0008298	66	0.723
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.716
establishment of tissue polarity	GO:0007164	87	0.673
regulation of cell differentiation	GO:0045595	302	0.643
single organism cellular localization	GO:1902580	180	0.643
morphogenesis of follicular epithelium	GO:0016333	36	0.609
axonogenesis	GO:0007409	290	0.606
synaptic transmission	GO:0007268	288	0.605
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.604
tube development	GO:0035295	244	0.602
transcription from rna polymerase ii promoter	GO:0006366	368	0.582
rna localization	GO:0006403	115	0.557
synapse organization	GO:0050808	196	0.554
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.529
meiotic nuclear division	GO:0007126	151	0.508
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.481
cell maturation	GO:0048469	144	0.472
synapse assembly	GO:0007416	143	0.468
regulation of oocyte development	GO:0060281	27	0.465
eye photoreceptor cell development	GO:0042462	81	0.459
zonula adherens assembly	GO:0045186	6	0.429
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.408
positive regulation of response to stimulus	GO:0048584	323	0.372
axon development	GO:0061564	297	0.370
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.370
embryonic axis specification	GO:0000578	107	0.367
establishment of planar polarity	GO:0001736	87	0.363
regulation of cell shape	GO:0008360	113	0.360
establishment or maintenance of cell polarity	GO:0007163	167	0.357
embryonic morphogenesis	GO:0048598	206	0.353
photoreceptor cell differentiation	GO:0046530	170	0.348
epithelial cell development	GO:0002064	274	0.329
organic substance transport	GO:0071702	257	0.322
immune system process	GO:0002376	347	0.321
ras protein signal transduction	GO:0007265	88	0.313
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.309
maintenance of cell polarity	GO:0030011	18	0.306
stem cell differentiation	GO:0048863	117	0.293
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.292
embryo development ending in birth or egg hatching	GO:0009792	152	0.289
establishment of cell polarity	GO:0030010	40	0.285
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.283
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.280
digestive tract development	GO:0048565	149	0.264
cellular response to organic substance	GO:0071310	132	0.264
establishment of localization in cell	GO:0051649	402	0.263
developmental maturation	GO:0021700	172	0.263
dna damage checkpoint	GO:0000077	78	0.256
regulation of neuron projection development	GO:0010975	69	0.251
meiotic cell cycle	GO:0051321	171	0.246
germarium derived oocyte differentiation	GO:0030706	29	0.243
negative regulation of signaling	GO:0023057	219	0.239
lipid metabolic process	GO:0006629	121	0.239
neuroblast fate commitment	GO:0014017	19	0.238
compound eye photoreceptor cell differentiation	GO:0001751	140	0.237
neuroblast differentiation	GO:0014016	29	0.231
intracellular protein transport	GO:0006886	104	0.225
dna integrity checkpoint	GO:0031570	81	0.223
regulation of cell morphogenesis	GO:0022604	163	0.223
establishment of epithelial cell apical basal polarity	GO:0045198	10	0.223
meiosis i	GO:0007127	59	0.223
mitotic nuclear division	GO:0007067	213	0.221
neuromuscular synaptic transmission	GO:0007274	67	0.221
establishment of mitochondrion localization	GO:0051654	7	0.219
cell cell junction assembly	GO:0007043	38	0.218
regulation of embryonic pattern specification	GO:1902875	27	0.218
nuclear division	GO:0000280	332	0.218
regulation of response to stress	GO:0080134	200	0.213
head involution	GO:0008258	35	0.212
spermatid development	GO:0007286	98	0.210
protein transport	GO:0015031	155	0.205
protein import into nucleus	GO:0006606	51	0.202
cellular protein catabolic process	GO:0044257	83	0.197
olfactory behavior	GO:0042048	97	0.196
protein localization to nucleus	GO:0034504	55	0.194
chemotaxis	GO:0006935	249	0.193
digestive system development	GO:0055123	149	0.192
oocyte dorsal ventral axis specification	GO:0007310	34	0.183
protein localization	GO:0008104	284	0.179
neuroblast proliferation	GO:0007405	74	0.178
actin cytoskeleton organization	GO:0030036	206	0.177
positive regulation of transcription dna templated	GO:0045893	266	0.175
positive regulation of signal transduction	GO:0009967	223	0.174
positive regulation of developmental process	GO:0051094	143	0.174
spindle organization	GO:0007051	253	0.174
photoreceptor cell development	GO:0042461	96	0.174
compound eye photoreceptor development	GO:0042051	78	0.173
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.167
dorsal closure	GO:0007391	79	0.165
biological adhesion	GO:0022610	138	0.165
ovarian fusome organization	GO:0030723	11	0.164
neuron projection guidance	GO:0097485	241	0.159
spermatogenesis	GO:0007283	200	0.157
eye photoreceptor cell differentiation	GO:0001754	145	0.155
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.152
asymmetric protein localization	GO:0008105	33	0.152
pronuclear migration	GO:0035046	4	0.151
organelle fission	GO:0048285	340	0.150
oocyte fate determination	GO:0030716	27	0.150
intracellular transport	GO:0046907	228	0.149
heart field specification	GO:0003128	0	0.147
stem cell maintenance	GO:0019827	67	0.147
ovarian follicle cell stalk formation	GO:0030713	17	0.146
dendrite morphogenesis	GO:0048813	199	0.145
negative regulation of gene expression	GO:0010629	387	0.143
rhythmic process	GO:0048511	106	0.143
cellular macromolecule catabolic process	GO:0044265	136	0.140
negative regulation of cell differentiation	GO:0045596	143	0.137
establishment or maintenance of monopolar cell polarity	GO:0061339	15	0.135
regulation of notch signaling pathway	GO:0008593	100	0.135
positive regulation of macromolecule metabolic process	GO:0010604	405	0.134
regulation of multicellular organism growth	GO:0040014	40	0.130
epithelial cell differentiation	GO:0030855	322	0.128
regulation of proteasomal protein catabolic process	GO:0061136	39	0.127
hemocyte migration	GO:0035099	19	0.126
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.126
negative regulation of signal transduction	GO:0009968	206	0.126
regulation of cellular ketone metabolic process	GO:0010565	3	0.126
gastrulation	GO:0007369	70	0.122
cell junction assembly	GO:0034329	42	0.120
negative regulation of epithelial cell proliferation	GO:0050680	4	0.119
establishment of ommatidial planar polarity	GO:0042067	49	0.119
lateral inhibition	GO:0046331	206	0.117
cytokinesis	GO:0000910	90	0.114
regulation of intracellular signal transduction	GO:1902531	236	0.114
cognition	GO:0050890	141	0.113
positive regulation of biosynthetic process	GO:0009891	316	0.112
regulation of cytoskeleton organization	GO:0051493	89	0.111
olfactory learning	GO:0008355	56	0.111
regulation of localization	GO:0032879	275	0.111
germarium derived female germ line cyst encapsulation	GO:0030708	8	0.108
cellular lipid metabolic process	GO:0044255	83	0.104
regulation of actin cytoskeleton organization	GO:0032956	42	0.103
axon guidance	GO:0007411	233	0.103
developmental growth	GO:0048589	280	0.102
cellular response to dna damage stimulus	GO:0006974	223	0.096
ovarian follicle cell development	GO:0030707	248	0.096
sensory organ morphogenesis	GO:0090596	260	0.095
gastrulation involving germ band extension	GO:0010004	36	0.094
secondary metabolic process	GO:0019748	75	0.094
cell fate determination	GO:0001709	91	0.094
peptidyl threonine phosphorylation	GO:0018107	2	0.093
asymmetric neuroblast division	GO:0055059	33	0.093
dendrite development	GO:0016358	204	0.093
positive regulation of signaling	GO:0023056	243	0.092
regulation of cellular component biogenesis	GO:0044087	201	0.091
positive regulation of multicellular organismal process	GO:0051240	143	0.089
neurological system process	GO:0050877	358	0.088
cellular protein complex assembly	GO:0043623	71	0.086
morphogenesis of a polarized epithelium	GO:0001738	93	0.086
cuticle development	GO:0042335	86	0.086
branching involved in open tracheal system development	GO:0060446	45	0.085
intracellular signal transduction	GO:0035556	300	0.085
adherens junction organization	GO:0034332	27	0.085
proteasomal protein catabolic process	GO:0010498	59	0.084
cell division	GO:0051301	248	0.084
negative regulation of cellular biosynthetic process	GO:0031327	277	0.082
positive regulation of gene expression	GO:0010628	290	0.081
centrosome organization	GO:0051297	163	0.080
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.080
single organism intracellular transport	GO:1902582	207	0.079
notch signaling pathway	GO:0007219	120	0.079
ommatidial rotation	GO:0016318	20	0.078
positive regulation of cell communication	GO:0010647	250	0.077
single organism biosynthetic process	GO:0044711	206	0.077
positive regulation of rna biosynthetic process	GO:1902680	266	0.077
single organism behavior	GO:0044708	391	0.077
cellular response to chemical stimulus	GO:0070887	199	0.077
mapk cascade	GO:0000165	107	0.076
positive regulation of cellular biosynthetic process	GO:0031328	316	0.076
establishment of apical basal cell polarity	GO:0035089	12	0.074
immune response	GO:0006955	246	0.074
small gtpase mediated signal transduction	GO:0007264	88	0.071
establishment of protein localization	GO:0045184	163	0.070
developmental growth involved in morphogenesis	GO:0060560	65	0.070
ovarian follicle cell migration	GO:0007297	121	0.070
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.067
dorsal appendage formation	GO:0046843	47	0.066
synaptic growth at neuromuscular junction	GO:0051124	119	0.066
negative regulation of stem cell proliferation	GO:2000647	30	0.065
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.065
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.065
regulation of neuron differentiation	GO:0045664	103	0.064
endomembrane system organization	GO:0010256	119	0.063
germ line cyst formation	GO:0048134	44	0.063
nuclear transcribed mrna catabolic process	GO:0000956	24	0.063
negative regulation of developmental process	GO:0051093	201	0.062
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.061
regulation of ras protein signal transduction	GO:0046578	93	0.061
cellular ketone metabolic process	GO:0042180	24	0.060
modification dependent protein catabolic process	GO:0019941	78	0.059
proteolysis	GO:0006508	192	0.059
regulation of cellular response to stress	GO:0080135	89	0.058
chorion containing eggshell formation	GO:0007304	105	0.058
centrosome cycle	GO:0007098	137	0.058
actin filament organization	GO:0007015	126	0.058
mitotic g2 dna damage checkpoint	GO:0007095	69	0.057
open tracheal system development	GO:0007424	204	0.057
adherens junction assembly	GO:0034333	11	0.057
regulation of response to external stimulus	GO:0032101	115	0.055
gland development	GO:0048732	191	0.054
regulation of phosphorylation	GO:0042325	147	0.054
compound eye morphogenesis	GO:0001745	249	0.054
cytoplasmic transport	GO:0016482	130	0.053
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.053
regulation of cellular amino acid metabolic process	GO:0006521	0	0.053
maintenance of location	GO:0051235	73	0.053
negative regulation of wnt signaling pathway	GO:0030178	28	0.053
establishment of epithelial cell polarity	GO:0090162	13	0.053
cell cell junction organization	GO:0045216	55	0.052
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.052
regulation of intracellular transport	GO:0032386	64	0.052
establishment of monopolar cell polarity	GO:0061162	15	0.051
regulation of multicellular organismal development	GO:2000026	414	0.051
positive regulation of phosphorylation	GO:0042327	87	0.051
modification dependent macromolecule catabolic process	GO:0043632	79	0.050
regulation of growth	GO:0040008	233	0.048
microtubule polymerization or depolymerization	GO:0031109	39	0.047
membrane organization	GO:0061024	112	0.047
ubiquitin dependent protein catabolic process	GO:0006511	78	0.046
regulation of cell projection organization	GO:0031344	92	0.046
establishment of nucleus localization	GO:0040023	26	0.045
multicellular organism growth	GO:0035264	46	0.045
wing disc morphogenesis	GO:0007472	344	0.045
mitotic cell cycle phase transition	GO:0044772	138	0.044
negative regulation of dendrite development	GO:2000171	2	0.044
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.044
mitotic dna integrity checkpoint	GO:0044774	75	0.044
negative regulation of biosynthetic process	GO:0009890	277	0.044
microtubule based transport	GO:0010970	42	0.044
regulation of phosphate metabolic process	GO:0019220	210	0.044
cellular protein modification process	GO:0006464	438	0.043
regulation of synapse assembly	GO:0051963	94	0.043
endocytosis	GO:0006897	310	0.043
innate immune response	GO:0045087	144	0.042
phagocytosis	GO:0006909	215	0.041
chitin based cuticle development	GO:0040003	49	0.041
protein targeting	GO:0006605	64	0.041
cellular component disassembly	GO:0022411	46	0.041
growth	GO:0040007	359	0.041
establishment or maintenance of epithelial cell apical basal polarity	GO:0045197	24	0.041
phosphorylation	GO:0016310	294	0.040
regulation of cellular component size	GO:0032535	98	0.040
compound eye development	GO:0048749	307	0.040
asymmetric protein localization involved in cell fate determination	GO:0045167	9	0.039
neuroblast division	GO:0055057	35	0.039
delamination	GO:0060232	8	0.039
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.039
regulation of reproductive process	GO:2000241	54	0.039
regulation of embryonic development	GO:0045995	68	0.038
protein modification process	GO:0036211	438	0.038
negative regulation of response to stimulus	GO:0048585	258	0.038
cellular response to oxygen containing compound	GO:1901701	79	0.038
regulation of microtubule based process	GO:0032886	49	0.037
establishment of spindle localization	GO:0051293	22	0.037
cell junction organization	GO:0034330	57	0.037
actin filament based process	GO:0030029	220	0.037
regulation of cell maturation	GO:1903429	27	0.037
regulation of actin filament length	GO:0030832	27	0.036
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.036
posttranscriptional regulation of gene expression	GO:0010608	145	0.036
regulation of transport	GO:0051049	181	0.035
meiotic cell cycle process	GO:1903046	132	0.035
imaginal disc derived wing morphogenesis	GO:0007476	337	0.035
signal transduction by phosphorylation	GO:0023014	107	0.034
regulation of endopeptidase activity	GO:0052548	36	0.034
protein polymerization	GO:0051258	42	0.033
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.033
positive regulation of cell development	GO:0010720	61	0.033
organic hydroxy compound metabolic process	GO:1901615	83	0.033
taxis	GO:0042330	304	0.032
specification of organ identity	GO:0010092	3	0.032
purine ribonucleotide catabolic process	GO:0009154	109	0.032
cell adhesion	GO:0007155	136	0.032
regulation of developmental growth	GO:0048638	174	0.032
imaginal disc pattern formation	GO:0007447	91	0.032
regulation of axonogenesis	GO:0050770	32	0.031
positive regulation of intracellular signal transduction	GO:1902533	116	0.031
gonad morphogenesis	GO:0035262	7	0.031
germ line cyst encapsulation	GO:0048138	8	0.030
eggshell chorion assembly	GO:0007306	66	0.030
oxoacid metabolic process	GO:0043436	103	0.030
mitotic spindle organization	GO:0007052	220	0.030
negative regulation of dendrite morphogenesis	GO:0050774	2	0.029
response to external biotic stimulus	GO:0043207	293	0.029
protein import	GO:0017038	55	0.028
peripheral nervous system development	GO:0007422	52	0.028
negative regulation of cellular metabolic process	GO:0031324	382	0.028
instar larval development	GO:0002168	55	0.028
regulation of intracellular protein transport	GO:0033157	46	0.028
forebrain development	GO:0030900	2	0.028
negative regulation of phosphatase activity	GO:0010923	3	0.027
nucleocytoplasmic transport	GO:0006913	72	0.026
negative regulation of neurogenesis	GO:0050768	53	0.026
cellular response to endogenous stimulus	GO:0071495	80	0.026
microtubule organizing center organization	GO:0031023	168	0.026
compound eye photoreceptor fate commitment	GO:0001752	36	0.026
regulation of phosphatase activity	GO:0010921	3	0.026
nuclear transport	GO:0051169	72	0.025
imaginal disc derived wing hair site selection	GO:0035320	4	0.025
skin development	GO:0043588	65	0.025
asymmetric cell division	GO:0008356	37	0.025
mitochondrion transport along microtubule	GO:0047497	5	0.025
regulation of multi organism process	GO:0043900	131	0.025
regulation of cellular amine metabolic process	GO:0033238	3	0.025
catabolic process	GO:0009056	409	0.025
regulation of sister chromatid cohesion	GO:0007063	2	0.024
cellular macromolecular complex assembly	GO:0034622	153	0.024
establishment of epithelial cell planar polarity	GO:0090163	4	0.024
retina morphogenesis in camera type eye	GO:0060042	2	0.023
positive regulation of intracellular transport	GO:0032388	42	0.023
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.023
cell cycle checkpoint	GO:0000075	95	0.023
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.023
negative regulation of microtubule depolymerization	GO:0007026	21	0.023
response to organic substance	GO:0010033	284	0.023
macromolecule catabolic process	GO:0009057	161	0.023
negative regulation of cell proliferation	GO:0008285	69	0.023
digestive tract morphogenesis	GO:0048546	127	0.022
eggshell chorion gene amplification	GO:0007307	9	0.022
eye development	GO:0001654	323	0.022
nuclear import	GO:0051170	51	0.022
larval development	GO:0002164	104	0.022
negative regulation of neuroblast proliferation	GO:0007406	27	0.022
positive regulation of protein export from nucleus	GO:0046827	1	0.022
amine metabolic process	GO:0009308	12	0.022
regulation of erk1 and erk2 cascade	GO:0070372	39	0.022
eye morphogenesis	GO:0048592	260	0.022
positive regulation of proteolysis	GO:0045862	52	0.021
female germline ring canal stabilization	GO:0008335	5	0.021
positive regulation of cell differentiation	GO:0045597	64	0.021
regulation of actin filament based process	GO:0032970	42	0.021
establishment of organelle localization	GO:0051656	122	0.021
establishment of protein localization to plasma membrane	GO:0090002	9	0.021
columnar cuboidal epithelial cell development	GO:0002066	249	0.021
positive regulation of cellular component organization	GO:0051130	156	0.021
developmental cell growth	GO:0048588	52	0.021
organic cyclic compound catabolic process	GO:1901361	168	0.021
positive regulation of mapk cascade	GO:0043410	63	0.021
eggshell formation	GO:0030703	105	0.021
entry into diapause	GO:0055115	1	0.021
protein localization to organelle	GO:0033365	82	0.020
rhabdomere development	GO:0042052	38	0.020
apical junction assembly	GO:0043297	32	0.020
regulation of cell substrate adhesion	GO:0010810	2	0.020
cystoblast division	GO:0007282	10	0.020
positive regulation of molecular function	GO:0044093	136	0.020
negative regulation of cell cycle process	GO:0010948	109	0.020
protein complex disassembly	GO:0043241	36	0.020
female germ line cyst encapsulation	GO:0048139	8	0.020
positive regulation of multicellular organism growth	GO:0040018	21	0.020
response to growth factor	GO:0070848	31	0.020
regulation of anatomical structure size	GO:0090066	163	0.019
positive regulation of neuron differentiation	GO:0045666	26	0.019
regulation of cell cycle	GO:0051726	291	0.019
r3 r4 cell fate commitment	GO:0007464	10	0.019
negative regulation of mitotic cell cycle	GO:0045930	109	0.019
response to oxygen containing compound	GO:1901700	200	0.019
positive regulation of phosphorus metabolic process	GO:0010562	139	0.019
response to abiotic stimulus	GO:0009628	341	0.019
negative regulation of heart induction	GO:1901320	3	0.019
g2 dna damage checkpoint	GO:0031572	69	0.019
negative regulation of growth	GO:0045926	84	0.019
regulation of epithelial cell proliferation	GO:0050678	4	0.019
stem cell development	GO:0048864	79	0.019
regulation of catalytic activity	GO:0050790	185	0.019
regulation of synaptic transmission	GO:0050804	69	0.019
dorsal ventral axis specification	GO:0009950	66	0.019
ovarian nurse cell to oocyte transport	GO:0007300	27	0.019
myoblast proliferation	GO:0051450	3	0.019
oocyte localization involved in germarium derived egg chamber formation	GO:0030720	12	0.019
positive regulation of ras protein signal transduction	GO:0046579	43	0.018
protein modification by small protein conjugation or removal	GO:0070647	106	0.018
response to radiation	GO:0009314	155	0.018
regulation of cell cell adhesion	GO:0022407	21	0.018
protein catabolic process	GO:0030163	101	0.018
single organismal cell cell adhesion	GO:0016337	45	0.018
regulation of cell junction assembly	GO:1901888	2	0.018
plasma membrane organization	GO:0007009	26	0.018
learning or memory	GO:0007611	141	0.017
bmp signaling pathway	GO:0030509	27	0.017
post embryonic appendage morphogenesis	GO:0035120	385	0.017
regulation of synapse structural plasticity	GO:0051823	3	0.017
cellularization	GO:0007349	90	0.017
epidermis development	GO:0008544	65	0.017
regulation of protein polymerization	GO:0032271	28	0.017
positive regulation of apoptotic process	GO:0043065	47	0.017
dorsal ventral axis specification ovarian follicular epithelium	GO:0008069	13	0.017
positive regulation of rna metabolic process	GO:0051254	271	0.017
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.017
exocrine system development	GO:0035272	162	0.017
single organism cell adhesion	GO:0098602	47	0.017
positive regulation of intracellular protein transport	GO:0090316	30	0.017
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.017
peptidyl tyrosine modification	GO:0018212	24	0.017
chorion containing eggshell pattern formation	GO:0030381	11	0.017
establishment of mitochondrion localization microtubule mediated	GO:0034643	6	0.017
dormancy process	GO:0022611	2	0.016
guanosine containing compound catabolic process	GO:1901069	74	0.016
pole plasm protein localization	GO:0007318	10	0.016
wound healing	GO:0042060	75	0.016
nitrogen compound transport	GO:0071705	85	0.016
posttranscriptional gene silencing by rna	GO:0035194	45	0.016
guanosine containing compound metabolic process	GO:1901068	74	0.015
wing disc pattern formation	GO:0035222	66	0.015
actomyosin contractile ring assembly	GO:0000915	10	0.015
appendage morphogenesis	GO:0035107	397	0.015
generation of precursor metabolites and energy	GO:0006091	42	0.015
purine ribonucleoside catabolic process	GO:0046130	112	0.015
regulation of nucleotide metabolic process	GO:0006140	62	0.015
centrosome duplication	GO:0051298	121	0.015
molting cycle	GO:0042303	56	0.015
establishment of spindle orientation	GO:0051294	18	0.015
regulation of cell cycle phase transition	GO:1901987	130	0.015
regulation of centrosome cycle	GO:0046605	7	0.015
hematopoietic or lymphoid organ development	GO:0048534	57	0.015
border follicle cell migration	GO:0007298	113	0.015
protein processing	GO:0016485	68	0.015
actin polymerization or depolymerization	GO:0008154	31	0.015
protein targeting to nucleus	GO:0044744	51	0.015
organic substance catabolic process	GO:1901575	308	0.014
regulation of synapse organization	GO:0050807	110	0.014
positive regulation of phosphate metabolic process	GO:0045937	139	0.014
sperm individualization	GO:0007291	48	0.014
stem cell division	GO:0017145	69	0.014
regulation of mitotic cell cycle	GO:0007346	190	0.014
negative regulation of cell communication	GO:0010648	223	0.014
habituation	GO:0046959	10	0.014
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.014
spindle stabilization	GO:0043146	14	0.014
cell growth	GO:0016049	108	0.014
motor neuron axon guidance	GO:0008045	58	0.014
fertilization	GO:0009566	26	0.014
regulation of compound eye photoreceptor development	GO:0045314	12	0.014
positive regulation of hydrolase activity	GO:0051345	78	0.014
positive regulation of actin filament polymerization	GO:0030838	11	0.013
carbohydrate metabolic process	GO:0005975	82	0.013
response to alcohol	GO:0097305	95	0.013
glial cell fate determination	GO:0007403	3	0.013
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.013
rna processing	GO:0006396	147	0.013
spindle localization	GO:0051653	22	0.013
regulation of cellular protein catabolic process	GO:1903362	44	0.013
neuroblast development	GO:0014019	13	0.013
lipid modification	GO:0030258	24	0.013
carboxylic acid metabolic process	GO:0019752	92	0.013
organelle localization	GO:0051640	148	0.013
negative regulation of multicellular organismal process	GO:0051241	142	0.013
regulation of stem cell differentiation	GO:2000736	14	0.013
regulation of establishment of protein localization	GO:0070201	61	0.013
regulation of mitosis	GO:0007088	56	0.013
positive regulation of peptidase activity	GO:0010952	29	0.013
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.012
mitotic g2 m transition checkpoint	GO:0044818	70	0.012
chromosome segregation	GO:0007059	157	0.012
maintenance of apical basal cell polarity	GO:0035090	8	0.012

aPKC disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.138

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