Drosophila melanogaster

17 known processes

m2 (Dmel_CG6104)

E(spl) region transcript m2

(Aliases: Dmel\CG6104,E(Spl)m2,HLHm2,E(spl)m2,CG6104)

m2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
neuron fate determinationGO:004866410.904
sensory organ precursor cell fate determinationGO:0016360190.862
regulation of neural precursor cell proliferationGO:2000177350.811
notch signaling pathwayGO:00072191200.765
formation of organ boundaryGO:0010160300.699
cell fate determinationGO:0001709910.575
nephron developmentGO:007200630.569
axon ensheathment in central nervous systemGO:003229130.563
nephron epithelium developmentGO:007200930.554
nephron epithelium morphogenesisGO:007208830.553
cell fate determination involved in pattern specificationGO:0060582190.548
r7 cell differentiationGO:0045466430.547
sensory organ boundary specificationGO:0008052220.546
nephron tubule morphogenesisGO:007207830.536
cell fate specificationGO:0001708710.531
nephron morphogenesisGO:007202830.519
glial cell fate commitmentGO:002178130.507
segment specificationGO:0007379330.504
kidney morphogenesisGO:006099330.501
kidney developmentGO:000182230.466
stem cell maintenanceGO:0019827670.446
r1 r6 cell differentiationGO:004805240.438
tyrosine phosphorylation of stat proteinGO:000726010.415
positive regulation of bmp signaling pathwayGO:003051350.405
dosage compensationGO:0007549160.351
stem cell developmentGO:0048864790.340
regionalizationGO:00030024160.340
nephron tubule developmentGO:007208030.340
regulation of notch signaling pathwayGO:00085931000.331
organ formationGO:0048645390.323
regulation of glial cell differentiationGO:004568510.323
neural precursor cell proliferationGO:0061351750.309
telencephalon developmentGO:002153720.308
immune system processGO:00023763470.305
regulation of bmp signaling pathwayGO:0030510230.301
neuroblast proliferationGO:0007405740.299
cell fate commitment involved in pattern specificationGO:0060581310.295
sex determinationGO:0007530180.286
cranial nerve developmentGO:002154510.283
nuclear divisionGO:00002803320.280
sensory organ morphogenesisGO:00905962600.268
camera type eye developmentGO:004301040.266
regulation of mitosisGO:0007088560.265
mitotic nuclear divisionGO:00070672130.265
hair cell differentiationGO:0035315470.263
regulation of hematopoietic progenitor cell differentiationGO:190153210.258
regulation of timing of cell differentiationGO:004850510.256
positive regulation of cellular amine metabolic processGO:003324000.248
regulation of tyrosine phosphorylation of stat proteinGO:004250910.239
regulation of epithelial cell differentiationGO:003085640.232
positive regulation of transcription dna templatedGO:00458932660.223
glial cell developmentGO:0021782270.221
glial cell differentiationGO:0010001350.211
eye morphogenesisGO:00485922600.206
neuronal stem cell maintenanceGO:009715040.200
positive regulation of cellular amino acid metabolic processGO:004576400.197
forebrain developmentGO:003090020.189
regulation of cell cycle processGO:00105641810.189
negative regulation of cell developmentGO:0010721620.182
stem cell fate specificationGO:004886620.177
regulation of mitotic cell cycleGO:00073461900.173
negative regulation of macromolecule biosynthetic processGO:00105582700.171
epithelial cell differentiationGO:00308553220.171
neuroblast fate specificationGO:001401820.168
organelle fissionGO:00482853400.163
response to abiotic stimulusGO:00096283410.160
epithelial tube formationGO:007217570.160
positive regulation of response to stimulusGO:00485843230.160
formation of anatomical boundaryGO:0048859370.156
nephron tubule formationGO:007207930.155
negative regulation of nucleic acid templated transcriptionGO:19035072400.154
sex determination establishment of x a ratioGO:000754010.149
brain developmentGO:00074201200.148
cellular amine metabolic processGO:0044106120.147
adult behaviorGO:00305341370.143
negative regulation of cell communicationGO:00106482230.143
negative regulation of nucleobase containing compound metabolic processGO:00459342610.142
humoral immune responseGO:00069591170.141
regulation of cell developmentGO:00602842150.141
organonitrogen compound metabolic processGO:19015643180.139
embryonic hindgut morphogenesisGO:0048619480.138
compound eye developmentGO:00487493070.137
regulation of cellular amino acid metabolic processGO:000652100.135
kidney epithelium developmentGO:007207330.134
renal tubule morphogenesisGO:0061333440.133
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.132
bmp signaling pathwayGO:0030509270.130
primary sex determination somaGO:000753920.130
smoothened signaling pathwayGO:0007224490.129
positive regulation of macromolecule metabolic processGO:00106044050.129
mesoderm developmentGO:0007498780.129
regulation of nervous system developmentGO:00519602480.128
regulation of transcription from rna polymerase ii promoterGO:00063573780.128
connective tissue developmentGO:006144830.125
regulation of cellular ketone metabolic processGO:001056530.122
compound eye morphogenesisGO:00017452490.122
negative regulation of cellular metabolic processGO:00313243820.122
somatic sex determinationGO:001899320.121
cell maturationGO:00484691440.120
eye photoreceptor cell differentiationGO:00017541450.117
positive regulation of rna biosynthetic processGO:19026802660.116
positive regulation of peptidyl tyrosine phosphorylationGO:005073140.116
tissue morphogenesisGO:00487292970.115
positive regulation of neural precursor cell proliferationGO:200017980.115
eye developmentGO:00016543230.115
stem cell proliferationGO:0072089880.115
regulation of cellular amine metabolic processGO:003323830.114
positive regulation of signal transductionGO:00099672230.113
negative regulation of nervous system developmentGO:0051961920.113
regulation of cell differentiationGO:00455953020.111
stem cell differentiationGO:00488631170.110
negative regulation of notch signaling pathwayGO:0045746410.110
segmentationGO:00352822070.110
morphogenesis of an epitheliumGO:00020092760.109
epidermal cell differentiationGO:0009913510.108
gliogenesisGO:0042063800.108
axonogenesisGO:00074092900.107
renal tubule developmentGO:0061326640.106
compound eye photoreceptor cell differentiationGO:00017511400.104
morphogenesis of a polarized epitheliumGO:0001738930.103
regulation of stem cell proliferationGO:0072091400.102
regulation of immune system processGO:00026821760.100
hindbrain developmentGO:003090220.100
chaeta developmentGO:0022416970.099
peptidyl tyrosine modificationGO:0018212240.097
spinal cord dorsal ventral patterningGO:002151310.096
regulation of cell morphogenesisGO:00226041630.095
organic acid metabolic processGO:00060821030.095
regulation of gliogenesisGO:0014013110.095
regulation of cellular amide metabolic processGO:0034248390.094
open tracheal system developmentGO:00074242040.094
positive regulation of signalingGO:00230562430.093
transcription from rna polymerase ii promoterGO:00063663680.093
cell cell signaling involved in cell fate commitmentGO:00451682100.093
dorsal ventral pattern formationGO:00099531330.092
tube developmentGO:00352952440.092
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092380.089
nerve developmentGO:002167560.089
positive regulation of nucleic acid templated transcriptionGO:19035082660.089
oxoacid metabolic processGO:00434361030.088
biological adhesionGO:00226101380.087
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.086
neuronal action potentialGO:0019228100.086
negative regulation of multicellular organismal processGO:00512411420.086
positive regulation of nervous system developmentGO:0051962690.085
positive regulation of developmental processGO:00510941430.085
negative regulation of cell differentiationGO:00455961430.083
cellular response to dna damage stimulusGO:00069742230.083
positive regulation of cell developmentGO:0010720610.083
gland developmentGO:00487321910.083
regulation of organelle organizationGO:00330431960.083
central nervous system developmentGO:00074172010.081
positive regulation of cell communicationGO:00106472500.080
spinal cord patterningGO:002151110.079
regulation of cell morphogenesis involved in differentiationGO:0010769610.079
malpighian tubule morphogenesisGO:0007443440.079
negative regulation of signal transductionGO:00099682060.078
regulation of response to stressGO:00801342000.078
somatic stem cell maintenanceGO:0035019140.077
small molecule metabolic processGO:00442813050.077
negative regulation of biosynthetic processGO:00098902770.076
regulation of nuclear divisionGO:0051783580.075
negative regulation of nitrogen compound metabolic processGO:00511722650.074
hematopoietic progenitor cell differentiationGO:000224410.074
regulation of antimicrobial peptide productionGO:0002784440.074
imaginal disc derived appendage morphogenesisGO:00351143950.073
positive regulation of notch signaling pathwayGO:0045747340.073
single organism behaviorGO:00447083910.073
cellular ketone metabolic processGO:0042180240.072
regulation of production of molecular mediator of immune responseGO:0002700440.072
intracellular signal transductionGO:00355563000.072
positive regulation of rna metabolic processGO:00512542710.071
positive regulation of cellular biosynthetic processGO:00313283160.071
cell divisionGO:00513012480.071
negative regulation of gene expressionGO:00106293870.070
urogenital system developmentGO:0001655720.070
positive regulation of cell differentiationGO:0045597640.070
negative regulation of cell cycle processGO:00109481090.070
imaginal disc pattern formationGO:0007447910.070
larval behaviorGO:0030537420.069
transmission of nerve impulseGO:0019226120.068
carboxylic acid metabolic processGO:0019752920.068
negative regulation of mitotic cell cycleGO:00459301090.068
regulation of response to external stimulusGO:00321011150.067
regulation of antimicrobial peptide biosynthetic processGO:0002805380.067
neuroepithelial cell differentiationGO:006056360.066
cellular amino acid metabolic processGO:0006520610.065
anterior posterior pattern specificationGO:00099521360.065
spinal cord developmentGO:002151010.065
positive regulation of nucleobase containing compound metabolic processGO:00459353320.065
startle responseGO:0001964160.064
epithelial cell developmentGO:00020642740.064
amine metabolic processGO:0009308120.063
adult locomotory behaviorGO:0008344760.061
protein complex biogenesisGO:00702712010.060
protein complex assemblyGO:00064612000.060
dendrite developmentGO:00163582040.059
ensheathment of neuronsGO:0007272100.059
positive regulation of nitrogen compound metabolic processGO:00511733540.058
epidermis developmentGO:0008544650.058
developmental maturationGO:00217001720.058
renal system developmentGO:0072001720.057
lateral inhibitionGO:00463312060.057
columnar cuboidal epithelial cell differentiationGO:00020652560.057
neural retina developmentGO:000340740.057
neurological system processGO:00508773580.057
regulation of cell cycleGO:00517262910.056
negative regulation of cellular biosynthetic processGO:00313272770.056
negative regulation of signalingGO:00230572190.055
cellular protein modification processGO:00064644380.055
positive regulation of multicellular organismal processGO:00512401430.055
axon developmentGO:00615642970.053
stem cell fate commitmentGO:0048865250.052
neuron projection guidanceGO:00974852410.052
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178650.051
peptidyl tyrosine phosphorylationGO:0018108240.051
embryonic morphogenesisGO:00485982060.050
proximal distal pattern formationGO:0009954150.050
chaeta morphogenesisGO:0008407420.049
regulation of neuroblast proliferationGO:1902692340.049
hemopoiesisGO:0030097460.048
negative regulation of immune system processGO:0002683500.048
protein modification processGO:00362114380.048
salivary gland developmentGO:00074311620.046
embryonic epithelial tube formationGO:000183860.046
regulation of cyclin dependent protein serine threonine kinase activityGO:000007930.046
regulation of axon guidanceGO:1902667100.046
positive regulation of gene expressionGO:00106282900.045
cell adhesionGO:00071551360.045
negative regulation of transcription dna templatedGO:00458922370.045
negative regulation of gliogenesisGO:001401460.045
locomotory behaviorGO:00076261760.045
peripheral nervous system developmentGO:0007422520.044
regulation of cell proliferationGO:00421271630.044
malpighian tubule tip cell differentiationGO:006138290.043
tube morphogenesisGO:00352391910.043
epithelial cell proliferation involved in renal tubule morphogenesisGO:2001013110.043
response to external biotic stimulusGO:00432072930.043
regulation of neurogenesisGO:00507671580.042
embryonic organ developmentGO:0048568500.042
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.042
gland morphogenesisGO:00226121450.041
regulation of multicellular organismal developmentGO:20000264140.041
negative regulation of neurogenesisGO:0050768530.041
response to other organismGO:00517072930.040
respiratory system developmentGO:00605412130.039
response to hypoxiaGO:0001666530.039
response to biotic stimulusGO:00096072940.039
wing disc pattern formationGO:0035222660.039
negative regulation of rna metabolic processGO:00512532510.039
appendage morphogenesisGO:00351073970.039
negative regulation of response to stimulusGO:00485852580.038
response to decreased oxygen levelsGO:0036293580.038
epithelial tube morphogenesisGO:0060562880.038
regulation of behaviorGO:0050795750.038
action potentialGO:0001508130.038
glandular epithelial cell differentiationGO:000206710.038
macromolecular complex assemblyGO:00650032560.037
regulation of cell divisionGO:0051302720.037
tube formationGO:0035148210.037
peptidyl amino acid modificationGO:00181931050.037
cellular amide metabolic processGO:0043603800.037
regulation of immune effector processGO:0002697520.036
phosphorylationGO:00163102940.036
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:009010090.036
regulation of gene expression epigeneticGO:00400291280.036
negative regulation of cellular component organizationGO:00511291080.036
enzyme linked receptor protein signaling pathwayGO:00071671790.036
positive regulation of cell cycleGO:0045787430.035
regulation of stem cell differentiationGO:2000736140.035
antimicrobial peptide productionGO:0002775460.034
regulation of membrane potentialGO:0042391350.034
neuron fate specificationGO:0048665120.034
hematopoietic or lymphoid organ developmentGO:0048534570.034
positive regulation of macromolecule biosynthetic processGO:00105572830.034
neuroblast fate determinationGO:0007400120.034
developmental growthGO:00485892800.034
appendage developmentGO:00487364010.034
jak stat cascadeGO:0007259490.033
neuroblast fate commitmentGO:0014017190.033
establishment of planar polarityGO:0001736870.033
antimicrobial humoral responseGO:0019730990.032
regulation of cellular response to stressGO:0080135890.032
regulation of antimicrobial humoral responseGO:0002759500.032
defense response to bacteriumGO:00427421780.032
regulation of wnt signaling pathwayGO:0030111680.032
wnt signaling pathwayGO:0016055980.032
negative regulation of rna biosynthetic processGO:19026792400.032
apoptotic process involved in morphogenesisGO:006056130.032
growthGO:00400073590.031
regulation of programmed cell deathGO:00430671520.031
head developmentGO:00603221350.031
negative regulation of cell cycleGO:00457861160.031
regulation of axon extension involved in axon guidanceGO:004884140.031
regulation of neuron differentiationGO:00456641030.031
ommatidial rotationGO:0016318200.030
morphogenesis of embryonic epitheliumGO:0016331940.030
epithelial cell proliferation involved in malpighian tubule morphogenesisGO:0061331110.030
bolwig s organ developmentGO:005503480.029
multicellular organismal signalingGO:0035637120.029
defense responseGO:00069523000.029
positive regulation of intracellular signal transductionGO:19025331160.029
cell deathGO:00082192790.029
positive regulation of neuroblast proliferationGO:000205270.028
developmental cell growthGO:0048588520.028
regulation of catalytic activityGO:00507901850.028
endoderm developmentGO:000749260.028
chromatin modificationGO:00165681470.028
negative regulation of stem cell differentiationGO:200073780.027
protein phosphorylationGO:00064681690.027
negative regulation of developmental processGO:00510932010.027
regulation of peptidyl tyrosine phosphorylationGO:0050730100.027
regulation of anatomical structure sizeGO:00900661630.026
immune effector processGO:0002252980.026
medulla oblongata developmentGO:002155020.026
photoreceptor cell differentiationGO:00465301700.026
immune responseGO:00069552460.026
positive regulation of neurogenesisGO:0050769410.026
positive regulation of biosynthetic processGO:00098913160.025
dorsal ventral pattern formation imaginal discGO:0007450510.025
stem cell fate determinationGO:0048867150.025
exocrine system developmentGO:00352721620.025
positive regulation of protein serine threonine kinase activityGO:0071902150.025
rhythmic processGO:00485111060.025
salivary gland morphogenesisGO:00074351450.025
positive regulation of cellular component organizationGO:00511301560.025
positive regulation of transferase activityGO:0051347260.025
larval locomotory behaviorGO:0008345270.024
regulation of cellular protein metabolic processGO:00322682430.024
production of molecular mediator of immune responseGO:0002440460.024
retina development in camera type eyeGO:006004140.024
positive regulation of programmed cell deathGO:0043068620.024
actin filament organizationGO:00070151260.024
peripheral nervous system neuron developmentGO:004893580.023
skin developmentGO:0043588650.023
peptide metabolic processGO:0006518800.023
response to oxygen levelsGO:0070482590.023
regulation of phosphorylationGO:00423251470.023
axon guidanceGO:00074112330.023
regulation of cell deathGO:00109411730.023
taxisGO:00423303040.023
neuron fate commitmentGO:0048663500.023
neuron projection extensionGO:1990138320.023
limb developmentGO:006017310.022
regulation of humoral immune responseGO:0002920510.022
programmed cell deathGO:00125012570.022
defense response to other organismGO:00985422250.022
brain morphogenesisGO:0048854160.022
regulation of molecular functionGO:00650092170.022
positive regulation of phosphorylationGO:0042327870.022
cellular response to radiationGO:0071478520.021
camera type eye morphogenesisGO:004859320.021
axon ensheathmentGO:0008366100.021
positive regulation of phosphorus metabolic processGO:00105621390.021
carbohydrate derivative metabolic processGO:19011352170.021
imaginal disc derived appendage developmentGO:00487373990.021
cell proliferationGO:00082832990.020
regulation of protein kinase activityGO:0045859510.020
imaginal disc derived wing morphogenesisGO:00074763370.020
cellular response to abiotic stimulusGO:0071214580.020
neuron projection extension involved in neuron projection guidanceGO:1902284100.020
positive regulation of neuron differentiationGO:0045666260.020
negative regulation of glial cell proliferationGO:006025360.020
positive regulation of catalytic activityGO:00430851180.019
establishment of tissue polarityGO:0007164870.019
catabolic processGO:00090564090.019
developmental programmed cell deathGO:00106231380.019
positive regulation of protein metabolic processGO:00512471280.019
regulation of intracellular signal transductionGO:19025312360.019
positive regulation of organelle organizationGO:0010638650.019
immune system developmentGO:0002520570.019
limb morphogenesisGO:003510810.019
regulation of phosphorus metabolic processGO:00511742100.018
positive regulation of mitotic cell cycleGO:0045931340.018
dendrite morphogenesisGO:00488131990.018
regulation of neuron projection developmentGO:0010975690.018
imaginal disc derived wing vein specificationGO:0007474480.018
peptide biosynthetic processGO:0043043420.018
regulation of phosphate metabolic processGO:00192202100.018
retina morphogenesis in camera type eyeGO:006004220.018
organic substance catabolic processGO:19015753080.018
negative regulation of organelle organizationGO:0010639560.018
regulation of multi organism processGO:00439001310.018
positive regulation of cell proliferationGO:0008284470.018
macromolecule catabolic processGO:00090571610.017
axon extension involved in axon guidanceGO:0048846100.017
regulation of response to biotic stimulusGO:0002831630.017
positive regulation of stem cell proliferationGO:200064880.017
digestive tract developmentGO:00485651490.017
positive regulation of phosphate metabolic processGO:00459371390.017
endocytosisGO:00068973100.017
positive regulation of protein kinase activityGO:0045860250.017
phagocytosisGO:00069092150.017
negative regulation of programmed cell deathGO:0043069720.017
organonitrogen compound biosynthetic processGO:19015661170.017
regulation of organ morphogenesisGO:2000027780.017
regulation of anatomical structure morphogenesisGO:00226032420.016
regulation of smoothened signaling pathwayGO:0008589280.016
antimicrobial peptide biosynthetic processGO:0002777380.016
vesicle mediated transportGO:00161923810.016
positive regulation of molecular functionGO:00440931360.016
regulation of kinase activityGO:0043549530.016
regulation of immune responseGO:00507761180.016
negative regulation of cell divisionGO:0051782170.016
regulation of response to dna damage stimulusGO:2001020230.016
body morphogenesisGO:001017120.016
apoptotic processGO:00069151590.015
amide biosynthetic processGO:0043604420.015
embryonic organ morphogenesisGO:004856250.015
wound healingGO:0042060750.015
negative regulation of neuron differentiationGO:0045665160.015
neuroblast differentiationGO:0014016290.014
peripheral nervous system neuron differentiationGO:004893480.014
regulation of protein serine threonine kinase activityGO:0071900250.014
wing disc dorsal ventral pattern formationGO:0048190470.014
regulation of hydrolase activityGO:0051336970.014
negative regulation of apoptotic processGO:0043066630.014
regulation of alternative mrna splicing via spliceosomeGO:0000381600.014
response to acid chemicalGO:0001101250.014
proteolysisGO:00065081920.013
neuromuscular processGO:0050905210.013
developmental pigmentationGO:0048066680.013
antennal developmentGO:0007469250.013
regulation of protein phosphorylationGO:0001932640.013
regulation of cell cycle phase transitionGO:19019871300.013
actin filament bundle organizationGO:0061572280.013
protein transportGO:00150311550.013
positive regulation of kinase activityGO:0033674250.013
positive regulation of cellular protein metabolic processGO:00322701180.013
protein catabolic processGO:00301631010.013
morphogenesis of a branching structureGO:0001763450.013
regulation of proteolysisGO:0030162870.012
epithelial cell proliferationGO:0050673150.012
central nervous system neuron developmentGO:002195480.012
regulation of reproductive processGO:2000241540.012
digestive tract morphogenesisGO:00485461270.012
regulation of developmental growthGO:00486381740.012
morphogenesis of a branching epitheliumGO:0061138450.012
wing disc morphogenesisGO:00074723440.012
gastrulation with mouth forming firstGO:0001703360.012
pigmentationGO:0043473750.012
response to oxygen containing compoundGO:19017002000.012
chemotaxisGO:00069352490.012
regulation of transferase activityGO:0051338580.012
regulation of jak stat cascadeGO:0046425430.011
lymph gland developmentGO:0048542280.011
compound eye retinal cell programmed cell deathGO:0046667230.011
response to alcoholGO:0097305950.011
proteolysis involved in cellular protein catabolic processGO:0051603830.011
multicellular organismal movementGO:005087930.011
circadian behaviorGO:0048512760.011
developmental inductionGO:003112830.011
response to ionizing radiationGO:0010212320.011
regulation of protein metabolic processGO:00512462560.011
organic substance transportGO:00717022570.011
leg disc developmentGO:0035218920.011
regulation of cell projection organizationGO:0031344920.011
response to organic substanceGO:00100332840.011
glial cell proliferationGO:0014009130.011
deathGO:00162652840.010
bolwig s organ morphogenesisGO:000174680.010
cellular component assembly involved in morphogenesisGO:00109271510.010
cellular catabolic processGO:00442483720.010
regulation of apoptotic processGO:00429811300.010
homeostatic processGO:00425921990.010

m2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
connective tissue diseaseDOID:6500.476
bone development diseaseDOID:008000600.476
bone diseaseDOID:008000100.476
disease of anatomical entityDOID:700.476
dysostosisDOID:193400.476
musculoskeletal system diseaseDOID:1700.476
spondylocostal dysostosisDOID:005056800.193
inherited metabolic disorderDOID:65500.013
disease of metabolismDOID:001466700.013