IMP: Integrative Multi-species Prediction

Drosophila melanogaster

86 known processes

Cenp-C (Dmel_CG31258)

CG31258 gene product from transcript CG31258-RA

(Aliases: CG11745,CG11746,Dmel\CG31258,l(3)85Aa,CENP-C,CLD1,L1,CG31258,Mmus\Numb[NPF.DPF.Scer\UAS])

Entrez: 41014
FLYBASE: FBgn0086697
UniProtKB: Q9VHP9

Process Predictions
Disease Predictions

Cenp-C biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
sister chromatid segregation	GO:0000819	92	0.990
chromosome segregation	GO:0007059	157	0.987
chromosome organization	GO:0051276	360	0.981
mitotic sister chromatid segregation	GO:0000070	87	0.975
meiotic cell cycle process	GO:1903046	132	0.951
spindle organization	GO:0007051	253	0.886
metaphase plate congression	GO:0051310	19	0.885
organelle localization	GO:0051640	148	0.845
meiotic nuclear division	GO:0007126	151	0.840
mitotic sister chromatid separation	GO:0051306	30	0.833
dna metabolic process	GO:0006259	227	0.759
meiotic cell cycle	GO:0051321	171	0.711
mitotic metaphase plate congression	GO:0007080	13	0.593
mitotic spindle stabilization	GO:0043148	6	0.579
nuclear division	GO:0000280	332	0.568
organelle fission	GO:0048285	340	0.565
meiotic spindle organization	GO:0000212	36	0.539
organelle assembly	GO:0070925	198	0.517
mitotic spindle organization	GO:0007052	220	0.513
establishment of organelle localization	GO:0051656	122	0.488
meiotic chromosome segregation	GO:0045132	59	0.481
chromosome condensation	GO:0030261	41	0.434
dna conformation change	GO:0071103	105	0.417
female meiosis chromosome segregation	GO:0016321	33	0.403
regulation of microtubule based process	GO:0032886	49	0.401
protein dna complex subunit organization	GO:0071824	86	0.362
regulation of cell cycle phase transition	GO:1901987	130	0.323
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.318
regulation of mitotic sister chromatid separation	GO:0010965	28	0.305
spindle midzone assembly	GO:0051255	4	0.297
cell cycle phase transition	GO:0044770	140	0.295
mitotic nuclear division	GO:0007067	213	0.289
mitotic chromosome condensation	GO:0007076	22	0.286
centrosome cycle	GO:0007098	137	0.285
spindle assembly involved in mitosis	GO:0090307	50	0.254
regulation of mitotic spindle organization	GO:0060236	9	0.243
chromosome localization	GO:0050000	20	0.242
positive regulation of metaphase anaphase transition of cell cycle	GO:1902101	10	0.240
chromosome movement towards spindle pole	GO:0051305	4	0.219
telomere organization	GO:0032200	21	0.209
positive regulation of mitotic sister chromatid separation	GO:1901970	10	0.205
regulation of proteasomal protein catabolic process	GO:0061136	39	0.185
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.184
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.183
photoreceptor cell differentiation	GO:0046530	170	0.176
dna damage checkpoint	GO:0000077	78	0.158
nuclear migration	GO:0007097	20	0.156
female meiotic division	GO:0007143	70	0.155
spindle assembly	GO:0051225	80	0.151
eye photoreceptor cell differentiation	GO:0001754	145	0.151
regulation of chromosome organization	GO:0033044	64	0.151
cellular macromolecular complex assembly	GO:0034622	153	0.149
chromosome separation	GO:0051304	42	0.148
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.142
catabolic process	GO:0009056	409	0.135
regulation of cellular catabolic process	GO:0031329	157	0.133
cell division	GO:0051301	248	0.123
dna packaging	GO:0006323	91	0.120
maintenance of protein location in cell	GO:0032507	26	0.118
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.114
centrosome duplication	GO:0051298	121	0.112
cell cycle checkpoint	GO:0000075	95	0.106
regulation of cell division	GO:0051302	72	0.105
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.104
establishment of chromosome localization	GO:0051303	20	0.103
modification dependent protein catabolic process	GO:0019941	78	0.101
microtubule based movement	GO:0007018	51	0.101
cellular protein catabolic process	GO:0044257	83	0.100
positive regulation of mitotic metaphase anaphase transition	GO:0045842	10	0.098
spindle assembly involved in meiosis	GO:0090306	20	0.097
cellular catabolic process	GO:0044248	372	0.096
protein dna complex assembly	GO:0065004	63	0.094
nucleosome organization	GO:0034728	59	0.093
wnt signaling pathway	GO:0016055	98	0.091
ubiquitin dependent protein catabolic process	GO:0006511	78	0.091
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.090
kinetochore organization	GO:0051383	9	0.089
microtubule depolymerization	GO:0007019	25	0.088
negative regulation of organelle organization	GO:0010639	56	0.087
cellular protein complex disassembly	GO:0043624	35	0.085
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.077
protein complex biogenesis	GO:0070271	201	0.075
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.073
maintenance of protein location	GO:0045185	28	0.073
axon development	GO:0061564	297	0.071
mitotic spindle midzone assembly	GO:0051256	1	0.068
cytoskeleton dependent cytokinesis	GO:0061640	81	0.066
heterocycle catabolic process	GO:0046700	166	0.066
transcription from rna polymerase ii promoter	GO:0006366	368	0.065
negative regulation of protein depolymerization	GO:1901880	23	0.065
centrosome organization	GO:0051297	163	0.064
regulation of protein complex disassembly	GO:0043244	29	0.063
meiotic sister chromatid segregation	GO:0045144	6	0.061
regulation of wnt signaling pathway	GO:0030111	68	0.060
regulation of mitotic cell cycle	GO:0007346	190	0.060
axonogenesis	GO:0007409	290	0.058
maintenance of location	GO:0051235	73	0.058
centromere complex assembly	GO:0034508	7	0.058
dendrite development	GO:0016358	204	0.058
establishment or maintenance of cell polarity	GO:0007163	167	0.057
body morphogenesis	GO:0010171	2	0.057
modification dependent macromolecule catabolic process	GO:0043632	79	0.055
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.055
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.054
muscle structure development	GO:0061061	224	0.054
cell death	GO:0008219	279	0.053
lateral inhibition	GO:0046331	206	0.051
metaphase anaphase transition of cell cycle	GO:0044784	28	0.050
regulation of gene silencing	GO:0060968	63	0.049
negative regulation of microtubule polymerization or depolymerization	GO:0031111	21	0.049
regulation of cellular protein catabolic process	GO:1903362	44	0.049
spindle assembly involved in female meiosis i	GO:0007057	5	0.049
cellular protein complex assembly	GO:0043623	71	0.048
appendage development	GO:0048736	401	0.047
germarium derived female germ line cyst formation	GO:0030727	42	0.047
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.047
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.047
aromatic compound catabolic process	GO:0019439	166	0.047
mitotic cell cycle phase transition	GO:0044772	138	0.046
spindle assembly involved in female meiosis	GO:0007056	14	0.046
cellular macromolecule catabolic process	GO:0044265	136	0.045
eye photoreceptor cell development	GO:0042462	81	0.044
regulation of catabolic process	GO:0009894	170	0.044
macromolecular complex assembly	GO:0065003	256	0.044
single organism catabolic process	GO:0044712	228	0.042
establishment of localization in cell	GO:0051649	402	0.042
vesicle mediated transport	GO:0016192	381	0.041
regulation of meiosis	GO:0040020	3	0.041
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.040
negative regulation of cell cycle	GO:0045786	116	0.039
organic substance catabolic process	GO:1901575	308	0.039
macromolecule catabolic process	GO:0009057	161	0.038
mitotic dna damage checkpoint	GO:0044773	74	0.037
negative regulation of microtubule depolymerization	GO:0007026	21	0.037
negative regulation of protein complex disassembly	GO:0043242	23	0.036
positive regulation of protein complex assembly	GO:0031334	22	0.036
dendrite morphogenesis	GO:0048813	199	0.036
positive regulation of macromolecule metabolic process	GO:0010604	405	0.036
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.036
telomere maintenance	GO:0000723	21	0.036
programmed cell death	GO:0012501	257	0.035
atp metabolic process	GO:0046034	49	0.035
regulation of protein catabolic process	GO:0042176	55	0.035
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.035
sensory organ morphogenesis	GO:0090596	260	0.035
embryonic morphogenesis	GO:0048598	206	0.034
phagocytosis	GO:0006909	215	0.034
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.034
pronuclear migration	GO:0035046	4	0.034
negative regulation of cell cycle process	GO:0010948	109	0.033
negative regulation of cytoskeleton organization	GO:0051494	30	0.033
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.033
photoreceptor cell development	GO:0042461	96	0.032
organic cyclic compound catabolic process	GO:1901361	168	0.032
meiotic spindle midzone assembly	GO:0051257	3	0.032
establishment of nucleus localization	GO:0040023	26	0.032
gliogenesis	GO:0042063	80	0.032
dna integrity checkpoint	GO:0031570	81	0.031
regulation of cell cycle	GO:0051726	291	0.031
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.031
glial cell differentiation	GO:0010001	35	0.031
mitotic cell cycle checkpoint	GO:0007093	88	0.031
regulation of neuron projection development	GO:0010975	69	0.031
dna replication	GO:0006260	48	0.030
protein localization	GO:0008104	284	0.030
synaptonemal complex organization	GO:0070193	5	0.029
chromatin remodeling	GO:0006338	72	0.029
chromatin modification	GO:0016568	147	0.029
protein complex disassembly	GO:0043241	36	0.029
positive regulation of protein catabolic process	GO:0045732	34	0.029
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.029
embryo development ending in birth or egg hatching	GO:0009792	152	0.029
protein depolymerization	GO:0051261	31	0.028
regulation of microtubule polymerization or depolymerization	GO:0031110	27	0.028
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.028
regulation of mitotic spindle elongation	GO:0032888	1	0.027
regulation of chromosome segregation	GO:0051983	32	0.027
embryonic cleavage	GO:0040016	5	0.027
mitotic dna integrity checkpoint	GO:0044774	75	0.027
regulation of sister chromatid segregation	GO:0033045	28	0.027
compound eye photoreceptor cell differentiation	GO:0001751	140	0.026
regulation of organelle organization	GO:0033043	196	0.026
neuroblast differentiation	GO:0014016	29	0.026
negative regulation of cell cycle g2 m phase transition	GO:1902750	8	0.026
positive regulation of transcription factor import into nucleus	GO:0042993	19	0.025
neuron projection guidance	GO:0097485	241	0.025
positive regulation of rna biosynthetic process	GO:1902680	266	0.025
digestive tract development	GO:0048565	149	0.024
chromatin assembly or disassembly	GO:0006333	52	0.024
positive regulation of mitotic cell cycle	GO:0045931	34	0.023
negative regulation of meiotic cell cycle	GO:0051447	2	0.023
cytokinesis	GO:0000910	90	0.023
death	GO:0016265	284	0.023
nucleosome assembly	GO:0006334	35	0.023
compound eye photoreceptor development	GO:0042051	78	0.023
meiotic sister chromatid cohesion	GO:0051177	6	0.023
glial cell development	GO:0021782	27	0.022
cellular response to dna damage stimulus	GO:0006974	223	0.022
microtubule organizing center organization	GO:0031023	168	0.022
nucleoside phosphate catabolic process	GO:1901292	110	0.022
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.022
regulation of microtubule depolymerization	GO:0031114	24	0.021
positive regulation of cellular biosynthetic process	GO:0031328	316	0.021
apoptotic process	GO:0006915	159	0.021
regulation of nuclear division	GO:0051783	58	0.021
microtubule anchoring	GO:0034453	11	0.021
attachment of spindle microtubules to kinetochore	GO:0008608	5	0.021
regulation of neuron differentiation	GO:0045664	103	0.021
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.021
positive regulation of rna metabolic process	GO:0051254	271	0.021
purine ribonucleoside catabolic process	GO:0046130	112	0.021
nucleus localization	GO:0051647	34	0.021
anatomical structure homeostasis	GO:0060249	97	0.021
compound eye development	GO:0048749	307	0.020
meiotic cytokinesis	GO:0033206	33	0.020
regulation of centrosome cycle	GO:0046605	7	0.020
response to other organism	GO:0051707	293	0.020
single organism membrane organization	GO:0044802	93	0.020
regulation of cellular component biogenesis	GO:0044087	201	0.020
cuticle development	GO:0042335	86	0.020
ribonucleoside metabolic process	GO:0009119	127	0.019
spindle stabilization	GO:0043146	14	0.019
maintenance of location in cell	GO:0051651	28	0.019
glial cell fate determination	GO:0007403	3	0.019
organonitrogen compound metabolic process	GO:1901564	318	0.019
regulation of protein depolymerization	GO:1901879	27	0.019
eye development	GO:0001654	323	0.019
endocytosis	GO:0006897	310	0.019
positive regulation of catabolic process	GO:0009896	105	0.019
positive regulation of cellular catabolic process	GO:0031331	95	0.018
cellular protein localization	GO:0034613	160	0.018
double strand break repair via synthesis dependent strand annealing	GO:0045003	6	0.018
limb morphogenesis	GO:0035108	1	0.018
telencephalon development	GO:0021537	2	0.018
pronuclear fusion	GO:0007344	4	0.018
regulation of spindle organization	GO:0090224	17	0.017
mitotic spindle elongation	GO:0000022	81	0.017
positive regulation of cellular component organization	GO:0051130	156	0.017
glycosyl compound catabolic process	GO:1901658	112	0.017
imaginal disc derived wing vein specification	GO:0007474	48	0.017
tube development	GO:0035295	244	0.017
regulation of cytoskeleton organization	GO:0051493	89	0.017
mrna splice site selection	GO:0006376	1	0.017
cellular component assembly involved in morphogenesis	GO:0010927	151	0.016
nucleotide catabolic process	GO:0009166	109	0.016
protein polymerization	GO:0051258	42	0.016
neuron recognition	GO:0008038	101	0.016
limb development	GO:0060173	1	0.016
imaginal disc derived wing morphogenesis	GO:0007476	337	0.016
gland morphogenesis	GO:0022612	145	0.016
positive regulation of cellular component biogenesis	GO:0044089	80	0.016
ectodermal digestive tract morphogenesis	GO:0048567	7	0.016
positive regulation of chromosome segregation	GO:0051984	10	0.016
female meiosis i	GO:0007144	8	0.016
chromatin organization	GO:0006325	207	0.015
macromolecular complex disassembly	GO:0032984	37	0.015
negative regulation of protein metabolic process	GO:0051248	85	0.015
axonal fasciculation	GO:0007413	12	0.015
somatic muscle development	GO:0007525	66	0.015
mitotic cytokinesis	GO:0000281	50	0.015
genitalia development	GO:0048806	26	0.015
negative regulation of cellular metabolic process	GO:0031324	382	0.015
positive regulation of r7 cell differentiation	GO:0045678	7	0.015
forebrain development	GO:0030900	2	0.015
autophagic cell death	GO:0048102	83	0.015
negative regulation of neuroblast proliferation	GO:0007406	27	0.015
tissue morphogenesis	GO:0048729	297	0.014
organonitrogen compound catabolic process	GO:1901565	128	0.014
cellular nitrogen compound catabolic process	GO:0044270	165	0.014
mitotic spindle assembly checkpoint	GO:0007094	11	0.014
establishment of spindle orientation	GO:0051294	18	0.014
regulation of dendrite development	GO:0050773	37	0.014
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.014
proteasomal protein catabolic process	GO:0010498	59	0.014
chemosensory behavior	GO:0007635	106	0.014
regulation of hemocyte proliferation	GO:0035206	37	0.014
cytoplasmic transport	GO:0016482	130	0.014
purine ribonucleotide metabolic process	GO:0009150	145	0.014
nucleoside triphosphate catabolic process	GO:0009143	108	0.014
neuroblast development	GO:0014019	13	0.014
nucleoside metabolic process	GO:0009116	127	0.013
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.013
germarium derived egg chamber formation	GO:0007293	101	0.013
embryonic development via the syncytial blastoderm	GO:0001700	148	0.013
ribonucleotide catabolic process	GO:0009261	109	0.013
mitotic centrosome separation	GO:0007100	8	0.013
response to abiotic stimulus	GO:0009628	341	0.013
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.013
telomere capping	GO:0016233	11	0.013
atp dependent chromatin remodeling	GO:0043044	22	0.013
peptidyl threonine phosphorylation	GO:0018107	2	0.013
purine ribonucleotide catabolic process	GO:0009154	109	0.013
spindle elongation	GO:0051231	83	0.013
ribonucleoside catabolic process	GO:0042454	112	0.013
organophosphate metabolic process	GO:0019637	195	0.013
regulation of chromatin assembly	GO:0010847	9	0.013
response to organonitrogen compound	GO:0010243	75	0.013
g2 dna damage checkpoint	GO:0031572	69	0.013
nephron epithelium development	GO:0072009	3	0.013
histone h4 k20 methylation	GO:0034770	4	0.013
epithelial cell development	GO:0002064	274	0.012
cell proliferation	GO:0008283	299	0.012
head involution	GO:0008258	35	0.012
positive regulation of biosynthetic process	GO:0009891	316	0.012
regulation of neuroblast proliferation	GO:1902692	34	0.012
small molecule metabolic process	GO:0044281	305	0.012
neuron remodeling	GO:0016322	29	0.012
dorsal appendage formation	GO:0046843	47	0.012
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.012
nucleobase containing compound catabolic process	GO:0034655	165	0.012
cellular macromolecule localization	GO:0070727	220	0.012
recombinational repair	GO:0000725	13	0.012
mitotic sister chromatid cohesion	GO:0007064	6	0.012
female germ line cyst formation	GO:0048135	42	0.011
single organism biosynthetic process	GO:0044711	206	0.011
negative regulation of mitotic sister chromatid separation	GO:2000816	13	0.011
negative regulation of neurogenesis	GO:0050768	53	0.011
chromosome organization involved in meiosis	GO:0070192	10	0.011
imaginal disc derived appendage development	GO:0048737	399	0.011
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.011
growth	GO:0040007	359	0.011
positive regulation of protein metabolic process	GO:0051247	128	0.011
salivary gland cell autophagic cell death	GO:0035071	83	0.011
membrane organization	GO:0061024	112	0.011
positive regulation of transcription dna templated	GO:0045893	266	0.011
eye morphogenesis	GO:0048592	260	0.011
eggshell chorion assembly	GO:0007306	66	0.011
morphogenesis of an epithelium	GO:0002009	276	0.011
negative regulation of mitotic cell cycle	GO:0045930	109	0.011
protein transport	GO:0015031	155	0.011
positive regulation of protein polymerization	GO:0032273	14	0.010
regulation of glial cell differentiation	GO:0045685	1	0.010
adult behavior	GO:0030534	137	0.010
appendage morphogenesis	GO:0035107	397	0.010
regulation of dna metabolic process	GO:0051052	34	0.010
male meiosis	GO:0007140	52	0.010
neuroblast fate commitment	GO:0014017	19	0.010
ribose phosphate metabolic process	GO:0019693	145	0.010
nucleolus organization	GO:0007000	4	0.010
photoreceptor cell fate commitment	GO:0046552	41	0.010
embryonic organ development	GO:0048568	50	0.010
neuron fate commitment	GO:0048663	50	0.010
axon guidance	GO:0007411	233	0.010
negative regulation of protein catabolic process	GO:0042177	17	0.010

Cenp-C disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.029

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