IMP: Integrative Multi-species Prediction

Drosophila melanogaster

44 known processes

dbo (Dmel_CG6224)

diablo

(Aliases: Dm.DBO,Smac,CG6224,DIABLO,Dmel\CG6224)

Entrez: 53556
FLYBASE: FBgn0040230
UniProtKB: M9PFL3
UniProtKB: Q9VUU5

Process Predictions
Disease Predictions

dbo biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
wing disc morphogenesis	GO:0007472	344	0.251
cellular catabolic process	GO:0044248	372	0.231	Human
protein modification process	GO:0036211	438	0.217	Human Fly
embryonic morphogenesis	GO:0048598	206	0.181
appendage morphogenesis	GO:0035107	397	0.177
protein localization	GO:0008104	284	0.170
growth	GO:0040007	359	0.154
appendage development	GO:0048736	401	0.154
actin filament based process	GO:0030029	220	0.145	Fly
imaginal disc derived wing morphogenesis	GO:0007476	337	0.143
macromolecule catabolic process	GO:0009057	161	0.132	Human
mrna metabolic process	GO:0016071	124	0.129
actin cytoskeleton organization	GO:0030036	206	0.109	Fly
post embryonic appendage morphogenesis	GO:0035120	385	0.097
cilium morphogenesis	GO:0060271	39	0.092
negative regulation of response to stimulus	GO:0048585	258	0.088
endocytosis	GO:0006897	310	0.083	Fly
organic substance catabolic process	GO:1901575	308	0.081	Human
positive regulation of catabolic process	GO:0009896	105	0.080
cellular macromolecule catabolic process	GO:0044265	136	0.077	Human
imaginal disc derived appendage development	GO:0048737	399	0.077
intracellular signal transduction	GO:0035556	300	0.075
positive regulation of rna metabolic process	GO:0051254	271	0.074
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.069
heterocycle catabolic process	GO:0046700	166	0.069
regionalization	GO:0003002	416	0.066
regulation of intracellular signal transduction	GO:1902531	236	0.065
regulation of cellular response to stress	GO:0080135	89	0.065
establishment or maintenance of cell polarity	GO:0007163	167	0.064
catabolic process	GO:0009056	409	0.063	Human
ameboidal type cell migration	GO:0001667	151	0.063	Fly
organelle assembly	GO:0070925	198	0.059
respiratory system development	GO:0060541	213	0.058
nucleobase containing compound catabolic process	GO:0034655	165	0.057
tissue morphogenesis	GO:0048729	297	0.056
rna processing	GO:0006396	147	0.053
morphogenesis of an epithelium	GO:0002009	276	0.053
morphogenesis of a polarized epithelium	GO:0001738	93	0.053
eye photoreceptor cell differentiation	GO:0001754	145	0.053
non sensory hair organization	GO:0035316	47	0.052
jnk cascade	GO:0007254	50	0.051
cellular macromolecule localization	GO:0070727	220	0.051
positive regulation of signal transduction	GO:0009967	223	0.050
positive regulation of response to stimulus	GO:0048584	323	0.050
digestive system development	GO:0055123	149	0.050
regulation of mrna metabolic process	GO:1903311	72	0.048
rubidium ion transport	GO:0035826	1	0.048
establishment of localization in cell	GO:0051649	402	0.048	Human
organelle localization	GO:0051640	148	0.047
phosphorylation	GO:0016310	294	0.046
positive regulation of cell communication	GO:0010647	250	0.045
body morphogenesis	GO:0010171	2	0.044
modification dependent macromolecule catabolic process	GO:0043632	79	0.044	Human
posttranscriptional regulation of gene expression	GO:0010608	145	0.043
response to organic substance	GO:0010033	284	0.042
cell division	GO:0051301	248	0.041
rna catabolic process	GO:0006401	37	0.041
positive regulation of signaling	GO:0023056	243	0.041
cellular macromolecular complex assembly	GO:0034622	153	0.041
actin filament organization	GO:0007015	126	0.040
embryonic axis specification	GO:0000578	107	0.039
chromosome segregation	GO:0007059	157	0.039
regulation of mrna processing	GO:0050684	71	0.039
cellular protein localization	GO:0034613	160	0.038
establishment of planar polarity	GO:0001736	87	0.038
establishment of cell polarity	GO:0030010	40	0.037
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.037
regulation of response to stress	GO:0080134	200	0.036
stress activated protein kinase signaling cascade	GO:0031098	55	0.036
compound eye development	GO:0048749	307	0.036
macromolecular complex assembly	GO:0065003	256	0.035
regulation of protein metabolic process	GO:0051246	256	0.034	Fly
mrna processing	GO:0006397	104	0.033
open tracheal system development	GO:0007424	204	0.033
regulation of cellular component biogenesis	GO:0044087	201	0.032
cell recognition	GO:0008037	102	0.032
negative regulation of cellular component organization	GO:0051129	108	0.032
establishment of monopolar cell polarity	GO:0061162	15	0.032
establishment of organelle localization	GO:0051656	122	0.032
regulation of cytoskeleton organization	GO:0051493	89	0.032
cell migration	GO:0016477	238	0.031	Fly
limb morphogenesis	GO:0035108	1	0.031
rrna processing	GO:0006364	3	0.031
embryonic development via the syncytial blastoderm	GO:0001700	148	0.031
regulation of cell cell adhesion	GO:0022407	21	0.031
regulation of anatomical structure size	GO:0090066	163	0.031
regulation of organelle organization	GO:0033043	196	0.031
synaptic target recognition	GO:0008039	45	0.030
phagocytosis	GO:0006909	215	0.030	Fly
rna splicing	GO:0008380	83	0.029
protein ubiquitination	GO:0016567	70	0.029	Human Fly
organic cyclic compound catabolic process	GO:1901361	168	0.029
regulation of multicellular organismal development	GO:2000026	414	0.029
positive regulation of macromolecule metabolic process	GO:0010604	405	0.029	Fly
cellular nitrogen compound catabolic process	GO:0044270	165	0.029
single organism intracellular transport	GO:1902582	207	0.028	Human
establishment of tissue polarity	GO:0007164	87	0.028
segmentation	GO:0035282	207	0.028
extracellular matrix constituent secretion	GO:0070278	4	0.027
limb development	GO:0060173	1	0.027
regulation of establishment of planar polarity	GO:0090175	22	0.027
cell cell adhesion via plasma membrane adhesion molecules	GO:0098742	26	0.027
mrna catabolic process	GO:0006402	33	0.026
embryonic pattern specification	GO:0009880	174	0.026
regulation of proteolysis	GO:0030162	87	0.026	Fly
positive regulation of gene expression	GO:0010628	290	0.026
negative regulation of gene expression	GO:0010629	387	0.025
regulation of wnt signaling pathway	GO:0030111	68	0.024
spermatid development	GO:0007286	98	0.024	Fly
regulation of phosphorylation	GO:0042325	147	0.024
proteolysis	GO:0006508	192	0.024	Human Fly
proteasomal protein catabolic process	GO:0010498	59	0.024	Human
male gamete generation	GO:0048232	201	0.024	Fly
establishment of protein localization	GO:0045184	163	0.023
stress activated mapk cascade	GO:0051403	52	0.023
cellular response to peptide	GO:1901653	28	0.023
positive regulation of proteolysis	GO:0045862	52	0.023	Fly
transcription from rna polymerase ii promoter	GO:0006366	368	0.023
protein transport	GO:0015031	155	0.023
central nervous system development	GO:0007417	201	0.023
ubiquitin dependent protein catabolic process	GO:0006511	78	0.023	Human
multi organism behavior	GO:0051705	175	0.023
imaginal disc derived wing hair organization	GO:0035317	45	0.023
establishment or maintenance of monopolar cell polarity	GO:0061339	15	0.023
regulation of cell morphogenesis	GO:0022604	163	0.023
modification dependent protein catabolic process	GO:0019941	78	0.023	Human
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.023
regulation of phosphorus metabolic process	GO:0051174	210	0.022
cellular response to dna damage stimulus	GO:0006974	223	0.022
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.022
establishment of epithelial cell apical basal polarity	GO:0045198	10	0.022
cellular protein modification process	GO:0006464	438	0.022	Human Fly
positive regulation of cellular catabolic process	GO:0031331	95	0.021
gene silencing	GO:0016458	138	0.021
positive regulation of transcription dna templated	GO:0045893	266	0.021
spindle organization	GO:0007051	253	0.021
anterior posterior axis specification	GO:0009948	109	0.021
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.021
o glycan processing	GO:0016266	3	0.021
convergent extension	GO:0060026	2	0.021
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.021
regulation of cellular protein metabolic process	GO:0032268	243	0.021	Fly
aromatic compound catabolic process	GO:0019439	166	0.021
regulation of cellular component size	GO:0032535	98	0.021
mapk cascade	GO:0000165	107	0.021
biological adhesion	GO:0022610	138	0.020
oligosaccharide metabolic process	GO:0009311	18	0.020
regulation of jnk cascade	GO:0046328	40	0.020
anterior posterior pattern specification	GO:0009952	136	0.020
protein modification by small protein conjugation	GO:0032446	79	0.020	Human Fly
regulation of localization	GO:0032879	275	0.020
carbohydrate biosynthetic process	GO:0016051	17	0.019
cell cell adhesion	GO:0098609	26	0.019
posttranscriptional gene silencing by rna	GO:0035194	45	0.019
signal transduction by phosphorylation	GO:0023014	107	0.019
negative regulation of cell communication	GO:0010648	223	0.019
nuclear transcribed mrna catabolic process	GO:0000956	24	0.019
sensory perception of chemical stimulus	GO:0007606	116	0.019
regulation of notch signaling pathway	GO:0008593	100	0.019
ribonucleoprotein complex subunit organization	GO:0071826	28	0.019
notch signaling pathway	GO:0007219	120	0.018
negative regulation of signal transduction	GO:0009968	206	0.018
establishment or maintenance of epithelial cell apical basal polarity	GO:0045197	24	0.018
response to abiotic stimulus	GO:0009628	341	0.018
dorsal ventral pattern formation	GO:0009953	133	0.018
wnt signaling pathway	GO:0016055	98	0.017
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.017
neuron recognition	GO:0008038	101	0.017
tube morphogenesis	GO:0035239	191	0.017
cilium organization	GO:0044782	41	0.017
blastoderm segmentation	GO:0007350	159	0.017
developmental growth	GO:0048589	280	0.017
rhythmic process	GO:0048511	106	0.017
circadian sleep wake cycle sleep	GO:0050802	23	0.017
chemosensory behavior	GO:0007635	106	0.016
compound eye photoreceptor development	GO:0042051	78	0.016
negative regulation of signaling	GO:0023057	219	0.016
response to radiation	GO:0009314	155	0.016
hair cell differentiation	GO:0035315	47	0.016
cell adhesion	GO:0007155	136	0.016
segment polarity determination	GO:0007367	25	0.016
rna localization	GO:0006403	115	0.016
negative regulation of cell proliferation	GO:0008285	69	0.016
nuclear division	GO:0000280	332	0.016
epithelial cell development	GO:0002064	274	0.016	Fly
establishment of imaginal disc derived wing hair orientation	GO:0001737	24	0.016
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.016
endosomal transport	GO:0016197	44	0.016	Human
negative regulation of wnt signaling pathway	GO:0030178	28	0.015
epithelial cell migration	GO:0010631	148	0.015	Fly
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.015
positive regulation of intracellular signal transduction	GO:1902533	116	0.015
ribonucleoprotein complex biogenesis	GO:0022613	31	0.015
cellular protein catabolic process	GO:0044257	83	0.015	Human
protein depolymerization	GO:0051261	31	0.015
cellular protein complex disassembly	GO:0043624	35	0.015
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.015
cytoplasmic transport	GO:0016482	130	0.015	Human
protein catabolic process	GO:0030163	101	0.015	Human
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.015
death	GO:0016265	284	0.015	Human Fly
regulation of stress activated mapk cascade	GO:0032872	41	0.015
digestive tract development	GO:0048565	149	0.015
regulation of rna splicing	GO:0043484	69	0.015
eye development	GO:0001654	323	0.015
ribonucleoprotein complex assembly	GO:0022618	23	0.015
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.014
response to biotic stimulus	GO:0009607	294	0.014
mrna splicing via spliceosome	GO:0000398	73	0.014
regulation of tube size open tracheal system	GO:0035151	43	0.014
inter male aggressive behavior	GO:0002121	60	0.014
response to external biotic stimulus	GO:0043207	293	0.014
neurological system process	GO:0050877	358	0.014
regulation of actin cytoskeleton organization	GO:0032956	42	0.014
vesicle mediated transport	GO:0016192	381	0.014	Human Fly
nuclear transport	GO:0051169	72	0.014
endomembrane system organization	GO:0010256	119	0.014
intracellular transport	GO:0046907	228	0.014	Human
regulation of phosphate metabolic process	GO:0019220	210	0.014
olfactory behavior	GO:0042048	97	0.014
intracellular protein transport	GO:0006886	104	0.014
epidermal cell differentiation	GO:0009913	51	0.013
tripartite regional subdivision	GO:0007351	103	0.013
cellular response to organonitrogen compound	GO:0071417	36	0.013
erbb signaling pathway	GO:0038127	58	0.013
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.013
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.013
digestive tract morphogenesis	GO:0048546	127	0.013
germarium derived egg chamber formation	GO:0007293	101	0.013	Fly
positive regulation of catalytic activity	GO:0043085	118	0.013	Fly
negative regulation of organelle organization	GO:0010639	56	0.013
eye morphogenesis	GO:0048592	260	0.013
protein targeting	GO:0006605	64	0.013
regulation of catalytic activity	GO:0050790	185	0.013	Fly
reproductive structure development	GO:0048608	74	0.013
cell migration involved in gastrulation	GO:0042074	9	0.013
ncrna processing	GO:0034470	30	0.013
alternative mrna splicing via spliceosome	GO:0000380	60	0.012
cell death	GO:0008219	279	0.012	Human Fly
photoreceptor cell development	GO:0042461	96	0.012
asymmetric protein localization	GO:0008105	33	0.012
vesicle organization	GO:0016050	44	0.012
homophilic cell adhesion via plasma membrane adhesion molecules	GO:0007156	18	0.012
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.012	Human
oligosaccharide biosynthetic process	GO:0009312	10	0.012
imaginal disc derived wing vein specification	GO:0007474	48	0.012
regulation of tube length open tracheal system	GO:0035159	24	0.012
motor neuron axon guidance	GO:0008045	58	0.012
smoothened signaling pathway	GO:0007224	49	0.012
regulation of epithelial cell proliferation	GO:0050678	4	0.012
positive regulation of cellular protein metabolic process	GO:0032270	118	0.012	Fly
humoral immune response	GO:0006959	117	0.012
positive regulation of phosphorylation	GO:0042327	87	0.012
regulation of cell shape	GO:0008360	113	0.012
epithelium migration	GO:0090132	148	0.012	Fly
cellular component assembly involved in morphogenesis	GO:0010927	151	0.012
protein complex biogenesis	GO:0070271	201	0.012
compound eye photoreceptor cell differentiation	GO:0001751	140	0.012
single organism cell adhesion	GO:0098602	47	0.012
defense response	GO:0006952	300	0.012
antimicrobial humoral response	GO:0019730	99	0.012
pigmentation	GO:0043473	75	0.012
regulation of growth	GO:0040008	233	0.012
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.012
protein complex assembly	GO:0006461	200	0.012
embryo development ending in birth or egg hatching	GO:0009792	152	0.012
chromosome organization	GO:0051276	360	0.012	Fly
positive regulation of phosphate metabolic process	GO:0045937	139	0.012
spermatid differentiation	GO:0048515	114	0.011	Fly
regulation of mrna splicing via spliceosome	GO:0048024	64	0.011
positive regulation of mapk cascade	GO:0043410	63	0.011
single organism behavior	GO:0044708	391	0.011
negative regulation of epithelial cell proliferation	GO:0050680	4	0.011
single organism cellular localization	GO:1902580	180	0.011
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.011
anterior posterior axis specification embryo	GO:0008595	103	0.011
cellular response to chemical stimulus	GO:0070887	199	0.011
carboxylic acid metabolic process	GO:0019752	92	0.011
rna splicing via transesterification reactions	GO:0000375	73	0.011
single organism catabolic process	GO:0044712	228	0.011
negative regulation of notch signaling pathway	GO:0045746	41	0.011
actin filament bundle organization	GO:0061572	28	0.011
aggressive behavior	GO:0002118	63	0.011
notch receptor processing	GO:0007220	13	0.011
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.010
tube development	GO:0035295	244	0.010
regulation of cellular response to growth factor stimulus	GO:0090287	13	0.010
regulation of gene expression epigenetic	GO:0040029	128	0.010
response to organonitrogen compound	GO:0010243	75	0.010
oxoacid metabolic process	GO:0043436	103	0.010
imaginal disc derived wing hair site selection	GO:0035320	4	0.010
small molecule metabolic process	GO:0044281	305	0.010
ommatidial rotation	GO:0016318	20	0.010
regulation of protein catabolic process	GO:0042176	55	0.010
positive regulation of rna biosynthetic process	GO:1902680	266	0.010
regulation of protein modification by small protein conjugation or removal	GO:1903320	25	0.010
regulation of protein modification process	GO:0031399	112	0.010
lateral inhibition	GO:0046331	206	0.010
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.010
imaginal disc derived leg morphogenesis	GO:0007480	80	0.010
organelle fission	GO:0048285	340	0.010
carbohydrate derivative metabolic process	GO:1901135	217	0.010
retina development in camera type eye	GO:0060041	4	0.010
regulation of organ morphogenesis	GO:2000027	78	0.010

dbo disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.014
disease of anatomical entity	DOID:7	0.012
nervous system disease	DOID:863	0.012
disease of cellular proliferation	DOID:14566	0.010
cancer	DOID:162	0.010
organ system cancer	DOID:0050686	0.010

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