Drosophila melanogaster

0 known processes

Nep1 (Dmel_CG5905)

Neprilysin 1

(Aliases: CG5914,CG5905,CG5894,dNEP1,Dmel\CG5905,NEP,DmeNEP1)

Nep1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to abiotic stimulusGO:00096283410.070
lateral inhibitionGO:00463312060.069
regionalizationGO:00030024160.068
synaptic transmissionGO:00072682880.067
positive regulation of response to stimulusGO:00485843230.065
axis specificationGO:00097981670.060
neurological system processGO:00508773580.058
positive regulation of cellular biosynthetic processGO:00313283160.056
negative regulation of gene expressionGO:00106293870.056
small molecule metabolic processGO:00442813050.055
positive regulation of nucleobase containing compound metabolic processGO:00459353320.054
axon developmentGO:00615642970.052
blastoderm segmentationGO:00073501590.047
single organism behaviorGO:00447083910.046
neuron projection guidanceGO:00974852410.045
positive regulation of transcription dna templatedGO:00458932660.045
regulation of catabolic processGO:00098941700.045
positive regulation of biosynthetic processGO:00098913160.044
cellular protein modification processGO:00064644380.043
carboxylic acid metabolic processGO:0019752920.042
camera type eye developmentGO:004301040.041
axonogenesisGO:00074092900.041
positive regulation of nitrogen compound metabolic processGO:00511733540.041
positive regulation of rna metabolic processGO:00512542710.041
response to organic substanceGO:00100332840.040
embryonic pattern specificationGO:00098801740.040
positive regulation of nucleic acid templated transcriptionGO:19035082660.040
positive regulation of macromolecule biosynthetic processGO:00105572830.040
positive regulation of cell communicationGO:00106472500.039
epithelial cell differentiationGO:00308553220.038
cell cell signaling involved in cell fate commitmentGO:00451682100.038
growthGO:00400073590.038
sensory organ morphogenesisGO:00905962600.037
Fly
protein modification processGO:00362114380.037
organic acid metabolic processGO:00060821030.037
chromatin organizationGO:00063252070.037
regulation of cellular ketone metabolic processGO:001056530.036
sensory perceptionGO:00076001960.036
ion transportGO:00068111450.036
organonitrogen compound metabolic processGO:19015643180.035
Rat
positive regulation of gene expressionGO:00106282900.035
nuclear divisionGO:00002803320.035
transcription from rna polymerase ii promoterGO:00063663680.034
regulation of localizationGO:00328792750.033
appendage developmentGO:00487364010.033
positive regulation of signalingGO:00230562430.033
catabolic processGO:00090564090.032
establishment of localization in cellGO:00516494020.032
positive regulation of macromolecule metabolic processGO:00106044050.032
segmentationGO:00352822070.031
negative regulation of cellular metabolic processGO:00313243820.031
morphogenesis of an epitheliumGO:00020092760.031
post embryonic appendage morphogenesisGO:00351203850.031
wnt signaling pathwayGO:0016055980.031
detection of stimulusGO:00516061560.030
positive regulation of rna biosynthetic processGO:19026802660.030
oxoacid metabolic processGO:00434361030.030
innate immune responseGO:00450871440.029
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.029
intracellular signal transductionGO:00355563000.029
respiratory system developmentGO:00605412130.029
columnar cuboidal epithelial cell differentiationGO:00020652560.029
response to glucoseGO:000974920.028
negative regulation of signal transductionGO:00099682060.028
locomotory behaviorGO:00076261760.028
regulation of wnt signaling pathwayGO:0030111680.028
response to oxygen containing compoundGO:19017002000.028
tripartite regional subdivisionGO:00073511030.028
cell deathGO:00082192790.028
deathGO:00162652840.028
regulation of cell cycleGO:00517262910.027
germarium derived egg chamber formationGO:00072931010.027
negative regulation of response to stimulusGO:00485852580.027
programmed cell deathGO:00125012570.027
appendage morphogenesisGO:00351073970.027
epithelial cell developmentGO:00020642740.027
transmembrane transportGO:00550851390.027
cellular catabolic processGO:00442483720.027
response to bacteriumGO:00096171980.026
kidney developmentGO:000182230.026
cellular amine metabolic processGO:0044106120.026
eye developmentGO:00016543230.026
Fly
immune responseGO:00069552460.026
regulation of cellular catabolic processGO:00313291570.025
response to light stimulusGO:00094161240.025
amine metabolic processGO:0009308120.025
taxisGO:00423303040.025
organic substance catabolic processGO:19015753080.025
negative regulation of biosynthetic processGO:00098902770.025
negative regulation of nucleobase containing compound metabolic processGO:00459342610.025
protein modification by small protein conjugation or removalGO:00706471060.025
eye morphogenesisGO:00485922600.025
Fly
imaginal disc derived appendage morphogenesisGO:00351143950.025
regulation of protein metabolic processGO:00512462560.025
compound eye developmentGO:00487493070.025
Fly
cellular macromolecule catabolic processGO:00442651360.025
chemotaxisGO:00069352490.025
dorsal ventral pattern formationGO:00099531330.024
response to monosaccharideGO:003428440.024
regulation of molecular functionGO:00650092170.024
body morphogenesisGO:001017120.024
chaeta developmentGO:0022416970.024
regulation of transportGO:00510491810.024
forebrain developmentGO:003090020.024
negative regulation of cell communicationGO:00106482230.023
axon guidanceGO:00074112330.023
defense responseGO:00069523000.023
immune system processGO:00023763470.023
response to external biotic stimulusGO:00432072930.023
cellular ketone metabolic processGO:0042180240.023
oocyte developmentGO:00485991240.023
organelle fissionGO:00482853400.023
embryonic axis specificationGO:00005781070.022
response to other organismGO:00517072930.022
negative regulation of transcription dna templatedGO:00458922370.022
spindle organizationGO:00070512530.022
defense response to bacteriumGO:00427421780.022
macromolecular complex assemblyGO:00650032560.021
response to biotic stimulusGO:00096072940.021
retina development in camera type eyeGO:006004140.021
cellular response to organic substanceGO:00713101320.021
male gamete generationGO:00482322010.021
developmental maturationGO:00217001720.021
regulation of response to stressGO:00801342000.021
central nervous system developmentGO:00074172010.021
anterior posterior axis specificationGO:00099481090.021
homeostatic processGO:00425921990.021
imaginal disc derived wing morphogenesisGO:00074763370.021
chromosome organizationGO:00512763600.021
cellular response to chemical stimulusGO:00708871990.021
tissue morphogenesisGO:00487292970.021
phagocytosisGO:00069092150.021
camera type eye morphogenesisGO:004859320.020
regulation of cellular protein metabolic processGO:00322682430.020
cell cycle phase transitionGO:00447701400.020
cellular macromolecule localizationGO:00707272200.020
rna localizationGO:00064031150.020
protein complex biogenesisGO:00702712010.020
negative regulation of cell differentiationGO:00455961430.020
anterior posterior pattern specificationGO:00099521360.020
mitotic cell cycle phase transitionGO:00447721380.020
negative regulation of cellular biosynthetic processGO:00313272770.020
regulation of mitotic cell cycle phase transitionGO:19019901300.020
regulation of immune system processGO:00026821760.020
neuron recognitionGO:00080381010.020
spermatogenesisGO:00072832000.019
chemical homeostasisGO:0048878920.019
organic substance transportGO:00717022570.019
synapse organizationGO:00508081960.019
response to lipopolysaccharideGO:003249640.019
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.019
proteolysisGO:00065081920.019
Human Rat Fly
gene silencing by rnaGO:0031047570.019
chemosensory behaviorGO:00076351060.019
response to hexoseGO:000974630.019
organophosphate metabolic processGO:00196371950.019
protein localizationGO:00081042840.018
regulation of gene silencingGO:0060968630.018
cognitionGO:00508901410.018
regulation of mitotic cell cycleGO:00073461900.018
olfactory behaviorGO:0042048970.018
mitotic nuclear divisionGO:00070672130.018
oocyte constructionGO:00073081120.018
cellular amino acid metabolic processGO:0006520610.018
negative regulation of signalingGO:00230572190.018
endocytosisGO:00068973100.018
intracellular transportGO:00469072280.018
regulation of phosphorus metabolic processGO:00511742100.018
defense response to other organismGO:00985422250.018
cellular response to carbohydrate stimulusGO:007132240.018
regulation of epithelial cell proliferationGO:005067840.017
negative regulation of developmental processGO:00510932010.017
small gtpase mediated signal transductionGO:0007264880.017
regulation of cell cycle processGO:00105641810.017
positive regulation of defense responseGO:0031349590.017
limb developmentGO:006017310.017
negative regulation of cellular protein metabolic processGO:0032269850.017
mesenchymal cell differentiationGO:004876210.017
positive regulation of signal transductionGO:00099672230.017
gene silencingGO:00164581380.017
open tracheal system developmentGO:00074242040.017
negative regulation of nucleic acid templated transcriptionGO:19035072400.017
regulation of intracellular signal transductionGO:19025312360.017
mesenchymal cell developmentGO:001403110.017
sensory perception of chemical stimulusGO:00076061160.017
positive regulation of cellular amino acid metabolic processGO:004576400.017
regulation of cell deathGO:00109411730.017
anterior posterior axis specification embryoGO:00085951030.017
head developmentGO:00603221350.017
negative regulation of multicellular organismal processGO:00512411420.017
compound eye morphogenesisGO:00017452490.017
Fly
nucleoside phosphate metabolic processGO:00067531620.017
wing disc morphogenesisGO:00074723440.016
cell maturationGO:00484691440.016
carbohydrate derivative metabolic processGO:19011352170.016
regulation of phosphate metabolic processGO:00192202100.016
ethanolamine containing compound metabolic processGO:004243940.016
regulation of programmed cell deathGO:00430671520.016
imaginal disc derived appendage developmentGO:00487373990.016
negative regulation of nitrogen compound metabolic processGO:00511722650.016
nitrogen compound transportGO:0071705850.016
nucleotide metabolic processGO:00091171610.016
single organism catabolic processGO:00447122280.016
developmental programmed cell deathGO:00106231380.016
columnar cuboidal epithelial cell developmentGO:00020662490.016
regulation of cellular amine metabolic processGO:003323830.016
vesicle mediated transportGO:00161923810.016
ovarian follicle cell developmentGO:00307072480.016
regulation of nervous system developmentGO:00519602480.015
positive regulation of catabolic processGO:00098961050.015
peptidyl lysine modificationGO:0018205570.015
neuropeptide signaling pathwayGO:0007218450.015
regulation of defense responseGO:00313471020.015
regulation of transcription from rna polymerase ii promoterGO:00063573780.015
multi multicellular organism processGO:00447061230.015
Fly
dorsal ventral axis specificationGO:0009950660.015
positive regulation of phosphorus metabolic processGO:00105621390.015
response to woundingGO:0009611940.015
cation transportGO:00068121100.015
regulation of multicellular organismal developmentGO:20000264140.015
regulation of anatomical structure sizeGO:00900661630.015
cellular response to dna damage stimulusGO:00069742230.015
cation homeostasisGO:0055080510.015
learningGO:0007612750.015
positive regulation of nucleotide metabolic processGO:0045981550.015
positive regulation of cellular catabolic processGO:0031331950.015
regulation of cell differentiationGO:00455953020.015
positive regulation of wnt signaling pathwayGO:0030177250.014
embryonic development via the syncytial blastodermGO:00017001480.014
cell proliferationGO:00082832990.014
negative regulation of rna metabolic processGO:00512532510.014
acetate ester metabolic processGO:190061920.014
photoreceptor cell developmentGO:0042461960.014
mitotic cell cycle checkpointGO:0007093880.014
positive regulation of phosphate metabolic processGO:00459371390.014
negative regulation of rna biosynthetic processGO:19026792400.014
tube developmentGO:00352952440.014
detection of stimulus involved in sensory perceptionGO:0050906920.014
response to endogenous stimulusGO:00097191190.014
negative regulation of protein metabolic processGO:0051248850.014
oocyte dorsal ventral axis specificationGO:0007310340.014
telencephalon developmentGO:002153720.014
establishment of protein localizationGO:00451841630.014
mitotic spindle organizationGO:00070522200.014
cellular response to hexose stimulusGO:007133110.014
positive regulation of protein metabolic processGO:00512471280.014
kidney morphogenesisGO:006099330.014
ribonucleotide metabolic processGO:00092591450.014
chromosome segregationGO:00070591570.014
leg disc developmentGO:0035218920.014
morphogenesis of a polarized epitheliumGO:0001738930.014
gliogenesisGO:0042063800.014
imaginal disc pattern formationGO:0007447910.014
nucleoside triphosphate catabolic processGO:00091431080.014
oocyte differentiationGO:00099941450.014
single organism biosynthetic processGO:00447112060.014
negative regulation of cell cycle phase transitionGO:19019881030.014
organelle assemblyGO:00709251980.014
neurotransmitter metabolic processGO:004213320.014
regulation of organelle organizationGO:00330431960.014
cellular macromolecular complex assemblyGO:00346221530.014
molting cycle chitin based cuticleGO:0007591560.014
eye photoreceptor cell differentiationGO:00017541450.014
microtubule organizing center organizationGO:00310231680.014
cell divisionGO:00513012480.014
response to organophosphorusGO:004668320.013
negative regulation of mitotic cell cycle phase transitionGO:19019911030.013
wound healingGO:0042060750.013
cellular homeostasisGO:0019725800.013
heterocycle catabolic processGO:00467001660.013
stem cell differentiationGO:00488631170.013
phosphorylationGO:00163102940.013
purine containing compound metabolic processGO:00725211550.013
peptidyl amino acid modificationGO:00181931050.013
regulation of innate immune responseGO:0045088710.013
posttranscriptional regulation of gene expressionGO:00106081450.013
positive regulation of molecular functionGO:00440931360.013
regulation of catalytic activityGO:00507901850.013
single organism intracellular transportGO:19025822070.013
cytoplasmic transportGO:00164821300.013
regulation of developmental growthGO:00486381740.013
peptidyl lysine acetylationGO:0018394390.013
digestive tract morphogenesisGO:00485461270.013
protein ubiquitinationGO:0016567700.013
pigmentationGO:0043473750.013
notch signaling pathwayGO:00072191200.013
salivary gland histolysisGO:0035070880.013
cellular response to monosaccharide stimulusGO:007132620.013
developmental growthGO:00485892800.013
intracellular mrna localizationGO:0008298660.013
cellular response to ethanolGO:007136140.013
intracellular mrna localization involved in pattern specification processGO:0060810560.013
carbohydrate derivative biosynthetic processGO:1901137850.013
cellular protein catabolic processGO:0044257830.013
limb morphogenesisGO:003510810.013
response to alcoholGO:0097305950.013
adult locomotory behaviorGO:0008344760.013
digestive system developmentGO:00551231490.013
biological adhesionGO:00226101380.013
organelle localizationGO:00516401480.013
centrosome organizationGO:00512971630.013
steroid catabolic processGO:000670610.013
response to sterolGO:0036314340.013
localization of cellGO:00516742570.013
l amino acid importGO:004309220.012
photoreceptor cell differentiationGO:00465301700.012
negative regulation of cell deathGO:0060548810.012
negative regulation of nervous system developmentGO:0051961920.012
secretionGO:00469031090.012
chorion containing eggshell formationGO:00073041050.012
centrosome cycleGO:00070981370.012
positive regulation of cell migrationGO:003033520.012
regulation of synapse structure and activityGO:00508031280.012
positive regulation of cellular amine metabolic processGO:003324000.012
single organism carbohydrate metabolic processGO:0044723720.012
regulation of immune responseGO:00507761180.012
adult behaviorGO:00305341370.012
multicellular organismal reproductive behaviorGO:00330571100.012
Fly
cellular response to lipopolysaccharideGO:007122230.012
detection of light stimulusGO:0009583580.012
sterol homeostasisGO:005509240.012
protein complex assemblyGO:00064612000.012
endomembrane system organizationGO:00102561190.012
triglyceride biosynthetic processGO:001943220.012
establishment of tissue polarityGO:0007164870.012
regulation of gene expression epigeneticGO:00400291280.012
g protein coupled receptor signaling pathwayGO:00071861360.012
purine nucleoside triphosphate metabolic processGO:00091441190.012
chromatin modificationGO:00165681470.012
protein catabolic processGO:00301631010.012
detection of chemical stimulus involved in sensory perceptionGO:0050907750.012
cellular protein localizationGO:00346131600.012
regulation of cellular component sizeGO:0032535980.012
negative regulation of programmed cell deathGO:0043069720.012
acetylcholine catabolic processGO:000658110.012
response to ecdysoneGO:0035075340.012
rhythmic processGO:00485111060.012
connective tissue developmentGO:006144830.012
negative regulation of cell cycleGO:00457861160.012
positive regulation of cell deathGO:0010942690.012
neuromuscular junction developmentGO:00075281490.012
cellular nitrogen compound catabolic processGO:00442701650.012
response to organic cyclic compoundGO:0014070890.012
regulation of cellular amino acid metabolic processGO:000652100.012
secretion by cellGO:00329401010.012
neuromuscular synaptic transmissionGO:0007274670.012
purine ribonucleotide metabolic processGO:00091501450.012
dna damage checkpointGO:0000077780.011
sleepGO:0030431490.011
stem cell developmentGO:0048864790.011
regulation of cell proliferationGO:00421271630.011
cellular response to oxygen containing compoundGO:1901701790.011
ras protein signal transductionGO:0007265880.011
sister chromatid segregationGO:0000819920.011
anatomical structure homeostasisGO:0060249970.011
regulation of apoptotic processGO:00429811300.011
compound eye photoreceptor developmentGO:0042051780.011
positive regulation of cellular protein metabolic processGO:00322701180.011
regulation of cell shapeGO:00083601130.011
meiotic cell cycleGO:00513211710.011
cell cycle checkpointGO:0000075950.011
nuclear transportGO:0051169720.011
aromatic compound catabolic processGO:00194391660.011
signal transduction by phosphorylationGO:00230141070.011
translationGO:0006412690.011
negative regulation of insulin secretionGO:004667610.011
spinal cord developmentGO:002151010.011
response to copper ionGO:004668840.011
brain developmentGO:00074201200.011
acetylcholine metabolic processGO:000829120.011
maternal determination of anterior posterior axis embryoGO:0008358740.011
acylglycerol biosynthetic processGO:004646320.011
nucleobase containing compound catabolic processGO:00346551650.011
associative learningGO:0008306650.011
compound eye photoreceptor cell differentiationGO:00017511400.011
nucleoside phosphate catabolic processGO:19012921100.011
signal releaseGO:0023061490.011
establishment of planar polarityGO:0001736870.011
negative regulation of developmental growthGO:0048640640.011
hindbrain developmentGO:003090220.011
regulation of notch signaling pathwayGO:00085931000.011
positive regulation of catalytic activityGO:00430851180.011
negative regulation of mitotic cell cycleGO:00459301090.011
regulation of anatomical structure morphogenesisGO:00226032420.011
macromolecule catabolic processGO:00090571610.011
carbohydrate metabolic processGO:0005975820.011
negative regulation of cell developmentGO:0010721620.011
regulation of cellular localizationGO:00603411360.011
single organism cellular localizationGO:19025801800.011
response to nitrogen compoundGO:1901698900.011
negative regulation of growthGO:0045926840.011
positive regulation of intracellular signal transductionGO:19025331160.011
regulation of cellular component biogenesisGO:00440872010.011
autophagic cell deathGO:0048102830.011
gland developmentGO:00487321910.010
positive regulation of hydrolase activityGO:0051345780.010
enzyme linked receptor protein signaling pathwayGO:00071671790.010
embryo development ending in birth or egg hatchingGO:00097921520.010
regulation of cell cycle phase transitionGO:19019871300.010
nucleobase containing small molecule metabolic processGO:00550861740.010
rhythmic behaviorGO:0007622760.010
defense response to gram negative bacteriumGO:0050829940.010
mitotic dna integrity checkpointGO:0044774750.010
cellular chemical homeostasisGO:0055082400.010
molting cycle processGO:0022404290.010
salivary gland developmentGO:00074311620.010
regulation of translationGO:0006417560.010
morphogenesis of embryonic epitheliumGO:0016331940.010
ion transmembrane transportGO:00342201220.010
gtp catabolic processGO:0006184720.010
immune response regulating signaling pathwayGO:000276420.010
cell recognitionGO:00080371020.010
organic cyclic compound catabolic processGO:19013611680.010
positive regulation of immune responseGO:0050778630.010
purine ribonucleoside triphosphate metabolic processGO:00092051190.010
response to radiationGO:00093141550.010
imaginal disc derived leg morphogenesisGO:0007480800.010
mapk cascadeGO:00001651070.010
cellular response to biotic stimulusGO:007121640.010
ubiquitin dependent protein catabolic processGO:0006511780.010
histolysisGO:00075591020.010
actin cytoskeleton organizationGO:00300362060.010
protein modification by small protein conjugationGO:0032446790.010
tissue deathGO:00162711020.010
chromatin silencingGO:0006342760.010
establishment or maintenance of cell polarityGO:00071631670.010

Nep1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.037
nervous system diseaseDOID:86300.020
disease of metabolismDOID:001466700.019
Human
inherited metabolic disorderDOID:65500.016
Human
sensory system diseaseDOID:005015500.015
eye diseaseDOID:561400.011
eye and adnexa diseaseDOID:149200.011
renal tubular transport diseaseDOID:44700.010
kidney diseaseDOID:55700.010
urinary system diseaseDOID:1800.010
musculoskeletal system diseaseDOID:1700.010
central nervous system diseaseDOID:33100.010
acquired metabolic diseaseDOID:006015800.010
cancerDOID:16200.010
disease of cellular proliferationDOID:1456600.010
organ system cancerDOID:005068600.010