IMP: Integrative Multi-species Prediction

Drosophila melanogaster

77 known processes

dsf (Dmel_CG9019)

dissatisfaction

(Aliases: DSF,CG9019,NR2E4,Dmel\CG9019)

FLYBASE: FBgn0015381
Entrez: 33823
UniProtKB: Q9VML1

Process Predictions
Disease Predictions

dsf biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
mating behavior	GO:0007617	106	0.993
multi multicellular organism process	GO:0044706	123	0.987
mating	GO:0007618	120	0.985
courtship behavior	GO:0007619	68	0.967
multi organism reproductive behavior	GO:0044705	121	0.963
reproductive behavior	GO:0019098	122	0.962
male mating behavior	GO:0060179	70	0.956
multi organism behavior	GO:0051705	175	0.917	Fly
multicellular organismal reproductive behavior	GO:0033057	110	0.842
male courtship behavior	GO:0008049	63	0.728
secondary metabolic process	GO:0019748	75	0.661
feeding behavior	GO:0007631	50	0.584
single organism behavior	GO:0044708	391	0.551	Fly
imaginal disc derived leg morphogenesis	GO:0007480	80	0.528
leg disc development	GO:0035218	92	0.478
secondary metabolite biosynthetic process	GO:0044550	24	0.362
leg disc morphogenesis	GO:0007478	80	0.318
g protein coupled receptor signaling pathway	GO:0007186	136	0.302
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.243
melanin metabolic process	GO:0006582	47	0.241
neuropeptide signaling pathway	GO:0007218	45	0.218
sensory perception	GO:0007600	196	0.215
defense response	GO:0006952	300	0.194
organic hydroxy compound metabolic process	GO:1901615	83	0.173
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.169
compound eye morphogenesis	GO:0001745	249	0.152
detection of stimulus involved in sensory perception	GO:0050906	92	0.130
macromolecular complex assembly	GO:0065003	256	0.123
positive regulation of response to stimulus	GO:0048584	323	0.120	Fly
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.119	Worm Fly
negative regulation of transcription dna templated	GO:0045892	237	0.115
establishment of localization in cell	GO:0051649	402	0.114	Fly
positive regulation of biosynthetic process	GO:0009891	316	0.114	Worm Fly
immune system process	GO:0002376	347	0.114
appendage development	GO:0048736	401	0.109	Fly
innate immune response	GO:0045087	144	0.107
response to oxygen containing compound	GO:1901700	200	0.104	Fly
immune response	GO:0006955	246	0.100
central nervous system development	GO:0007417	201	0.097	Fly
response to other organism	GO:0051707	293	0.095
pigment metabolic process	GO:0042440	84	0.088
response to organic substance	GO:0010033	284	0.088	Fly
male courtship behavior tapping to detect pheromone	GO:0016544	1	0.086
imaginal disc derived appendage development	GO:0048737	399	0.084	Fly
single organism biosynthetic process	GO:0044711	206	0.081
antennal development	GO:0007469	25	0.081
malpighian tubule morphogenesis	GO:0007443	44	0.081
antennal morphogenesis	GO:0048800	14	0.079
eye development	GO:0001654	323	0.074
limb development	GO:0060173	1	0.070
post embryonic appendage morphogenesis	GO:0035120	385	0.070	Fly
compound eye development	GO:0048749	307	0.068
embryo development ending in birth or egg hatching	GO:0009792	152	0.068
taxis	GO:0042330	304	0.067	Fly
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.066	Worm Fly
eye morphogenesis	GO:0048592	260	0.064
response to endogenous stimulus	GO:0009719	119	0.063	Fly
locomotory behavior	GO:0007626	176	0.062	Fly
cranial nerve development	GO:0021545	1	0.061
male courtship behavior veined wing vibration	GO:0016545	21	0.061
hormone metabolic process	GO:0042445	33	0.059
melanization defense response	GO:0035006	45	0.057
positive regulation of signal transduction	GO:0009967	223	0.056
dorsal ventral pattern formation	GO:0009953	133	0.056
somatic muscle development	GO:0007525	66	0.054
protein complex assembly	GO:0006461	200	0.054
negative regulation of biosynthetic process	GO:0009890	277	0.054
male courtship behavior veined wing extension	GO:0048065	22	0.053
ovarian follicle cell development	GO:0030707	248	0.052	Fly
cellular response to chemical stimulus	GO:0070887	199	0.052	Fly
appendage morphogenesis	GO:0035107	397	0.052	Fly
cellular protein modification process	GO:0006464	438	0.051
response to bacterium	GO:0009617	198	0.050
regulation of phosphorus metabolic process	GO:0051174	210	0.050
chemosensory behavior	GO:0007635	106	0.050
response to external biotic stimulus	GO:0043207	293	0.049
small molecule metabolic process	GO:0044281	305	0.049
phenol containing compound metabolic process	GO:0018958	57	0.049
negative regulation of cellular biosynthetic process	GO:0031327	277	0.048
adult behavior	GO:0030534	137	0.048
morphogenesis of an epithelium	GO:0002009	276	0.048
organonitrogen compound metabolic process	GO:1901564	318	0.048
response to abiotic stimulus	GO:0009628	341	0.048
response to light stimulus	GO:0009416	124	0.047
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.047	Worm Fly
defense response to bacterium	GO:0042742	178	0.047
catabolic process	GO:0009056	409	0.047
eye antennal disc morphogenesis	GO:0007455	34	0.046
sensory organ morphogenesis	GO:0090596	260	0.046
positive regulation of cell communication	GO:0010647	250	0.045
response to biotic stimulus	GO:0009607	294	0.045
camera type eye development	GO:0043010	4	0.045
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.044
reproductive system development	GO:0061458	74	0.043	Worm
phototaxis	GO:0042331	21	0.043
neurological system process	GO:0050877	358	0.043
lipid metabolic process	GO:0006629	121	0.043
defense response to other organism	GO:0098542	225	0.042
negative regulation of cell differentiation	GO:0045596	143	0.042
larval behavior	GO:0030537	42	0.042
single organism cellular localization	GO:1902580	180	0.042
cellular amine metabolic process	GO:0044106	12	0.042
negative regulation of gene expression	GO:0010629	387	0.041
negative regulation of cellular metabolic process	GO:0031324	382	0.041
cell division	GO:0051301	248	0.040	Fly
amine metabolic process	GO:0009308	12	0.040
regulation of anatomical structure size	GO:0090066	163	0.040	Fly
establishment of protein localization	GO:0045184	163	0.040
regulation of immune system process	GO:0002682	176	0.038
sensory perception of sound	GO:0007605	56	0.038
regionalization	GO:0003002	416	0.037	Fly
tissue morphogenesis	GO:0048729	297	0.037
regulation of cell cycle	GO:0051726	291	0.036	Fly
mesenchymal cell differentiation	GO:0048762	1	0.036
regulation of hormone levels	GO:0010817	40	0.035
response to radiation	GO:0009314	155	0.035
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.035	Worm Fly
stem cell development	GO:0048864	79	0.035
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.034	Fly
tube morphogenesis	GO:0035239	191	0.034
immune effector process	GO:0002252	98	0.034
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.034
regulation of cell fate specification	GO:0042659	27	0.033
determination of imaginal disc primordium	GO:0007445	11	0.031
connective tissue development	GO:0061448	3	0.031
regulation of cell fate commitment	GO:0010453	29	0.030
single organism intracellular transport	GO:1902582	207	0.030
positive regulation of signaling	GO:0023056	243	0.029
cellular protein localization	GO:0034613	160	0.029
regulation of localization	GO:0032879	275	0.029	Fly
regulation of cellular localization	GO:0060341	136	0.029
regulation of cell proliferation	GO:0042127	163	0.029
protein complex biogenesis	GO:0070271	201	0.028
limb morphogenesis	GO:0035108	1	0.028
nephron epithelium development	GO:0072009	3	0.027
positive regulation of rna biosynthetic process	GO:1902680	266	0.027	Worm Fly
response to nitrogen compound	GO:1901698	90	0.027
regulation of epithelial cell proliferation	GO:0050678	4	0.027
detection of stimulus	GO:0051606	156	0.026
negative regulation of rna metabolic process	GO:0051253	251	0.026
morphogenesis of embryonic epithelium	GO:0016331	94	0.026
response to extracellular stimulus	GO:0009991	116	0.026
mating behavior sex discrimination	GO:0048047	7	0.026
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.025	Fly
intracellular transport	GO:0046907	228	0.025
sesquiterpenoid metabolic process	GO:0006714	3	0.025
phagocytosis	GO:0006909	215	0.025
dendrite development	GO:0016358	204	0.025	Fly
cellular response to endogenous stimulus	GO:0071495	80	0.024	Fly
digestive tract development	GO:0048565	149	0.024
male gamete generation	GO:0048232	201	0.024
negative regulation of response to stimulus	GO:0048585	258	0.024
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.024
gliogenesis	GO:0042063	80	0.024
response to acid chemical	GO:0001101	25	0.023
negative regulation of rna biosynthetic process	GO:1902679	240	0.023
inter male aggressive behavior	GO:0002121	60	0.023	Fly
regulation of apoptotic process	GO:0042981	130	0.023
digestive tract morphogenesis	GO:0048546	127	0.023
rhythmic behavior	GO:0007622	76	0.023	Fly
response to organonitrogen compound	GO:0010243	75	0.023
open tracheal system development	GO:0007424	204	0.023
protein modification process	GO:0036211	438	0.022
secretion	GO:0046903	109	0.022	Fly
organic substance transport	GO:0071702	257	0.022
cell recognition	GO:0008037	102	0.022
sex differentiation	GO:0007548	81	0.022	Worm
forebrain development	GO:0030900	2	0.021
pheromone biosynthetic process	GO:0042811	3	0.021
hormone biosynthetic process	GO:0042446	20	0.021
energy taxis	GO:0009453	21	0.021
sensory perception of mechanical stimulus	GO:0050954	72	0.021
cellular amino acid metabolic process	GO:0006520	61	0.021
larval development	GO:0002164	104	0.021
cellular macromolecule localization	GO:0070727	220	0.021
multicellular organismal aging	GO:0010259	140	0.021
brain development	GO:0007420	120	0.020	Fly
cardioblast differentiation	GO:0010002	20	0.020
protein phosphorylation	GO:0006468	169	0.020
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.020
reproductive structure development	GO:0048608	74	0.020	Worm
regulation of chitin based cuticle tanning	GO:0007564	14	0.020
spermatogenesis	GO:0007283	200	0.020
pigmentation	GO:0043473	75	0.020
molting cycle chitin based cuticle	GO:0007591	56	0.020
photoreceptor cell differentiation	GO:0046530	170	0.020
protein localization	GO:0008104	284	0.020
organ growth	GO:0035265	56	0.019
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.019
stem cell differentiation	GO:0048863	117	0.019
positive regulation of cellular biosynthetic process	GO:0031328	316	0.019	Worm Fly
dendrite morphogenesis	GO:0048813	199	0.019	Fly
catecholamine biosynthetic process	GO:0042423	3	0.019
homeostatic process	GO:0042592	199	0.019
epidermal cell differentiation	GO:0009913	51	0.019
r7 cell differentiation	GO:0045466	43	0.018
epithelial tube morphogenesis	GO:0060562	88	0.018
regulation of reproductive process	GO:2000241	54	0.018
retina morphogenesis in camera type eye	GO:0060042	2	0.018
retinal cone cell differentiation	GO:0042670	2	0.018
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.018
positive regulation of transcription dna templated	GO:0045893	266	0.017	Worm Fly
cellular response to oxygen containing compound	GO:1901701	79	0.017	Fly
body morphogenesis	GO:0010171	2	0.017
organic substance catabolic process	GO:1901575	308	0.017
retina development in camera type eye	GO:0060041	4	0.017
muscle organ development	GO:0007517	127	0.017	Fly
cardiac cell fate commitment	GO:0060911	17	0.017
embryonic morphogenesis	GO:0048598	206	0.016
molting cycle	GO:0042303	56	0.016
organic cyclic compound catabolic process	GO:1901361	168	0.016
regulation of cell cycle process	GO:0010564	181	0.016
male courtship behavior veined wing generated song production	GO:0045433	20	0.016
immune response regulating signaling pathway	GO:0002764	2	0.016
regulation of phosphate metabolic process	GO:0019220	210	0.016
neural retina development	GO:0003407	4	0.015
response to growth factor	GO:0070848	31	0.015
glial cell differentiation	GO:0010001	35	0.015
mesenchymal cell development	GO:0014031	1	0.015
hindbrain development	GO:0030902	2	0.015
female mating behavior	GO:0060180	30	0.015
nucleoside phosphate metabolic process	GO:0006753	162	0.015
aging	GO:0007568	143	0.015
axonogenesis	GO:0007409	290	0.015	Fly
compound eye photoreceptor cell differentiation	GO:0001751	140	0.015
cell death	GO:0008219	279	0.015
positive regulation of immune response	GO:0050778	63	0.014
regulation of innate immune response	GO:0045088	71	0.014
intraspecies interaction between organisms	GO:0051703	4	0.014
imaginal disc derived wing morphogenesis	GO:0007476	337	0.014	Fly
response to gravity	GO:0009629	26	0.014
regulation of catalytic activity	GO:0050790	185	0.014
camera type eye photoreceptor cell differentiation	GO:0060219	2	0.014
ethanolamine containing compound metabolic process	GO:0042439	4	0.014
carbohydrate derivative metabolic process	GO:1901135	217	0.014
renal system development	GO:0072001	72	0.014
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.013	Fly
chaeta morphogenesis	GO:0008407	42	0.013
regulation of growth	GO:0040008	233	0.013	Worm Fly
cellular catabolic process	GO:0044248	372	0.013
immune response activating signal transduction	GO:0002757	2	0.013
response to inorganic substance	GO:0010035	44	0.013
positive regulation of phosphorus metabolic process	GO:0010562	139	0.013
negative regulation of apoptotic process	GO:0043066	63	0.013
epithelial structure maintenance	GO:0010669	17	0.013
endocytosis	GO:0006897	310	0.013
respiratory system development	GO:0060541	213	0.013
death	GO:0016265	284	0.013
eye photoreceptor cell differentiation	GO:0001754	145	0.013
imaginal disc pattern formation	GO:0007447	91	0.013
embryonic development via the syncytial blastoderm	GO:0001700	148	0.013
regulation of cellular component size	GO:0032535	98	0.013	Fly
organelle localization	GO:0051640	148	0.013
epithelial cell differentiation	GO:0030855	322	0.013	Fly
activation of innate immune response	GO:0002218	4	0.013
compound eye photoreceptor development	GO:0042051	78	0.013
programmed cell death	GO:0012501	257	0.013
response to copper ion	GO:0046688	4	0.013
organophosphate metabolic process	GO:0019637	195	0.013
developmental maturation	GO:0021700	172	0.013	Fly
biological adhesion	GO:0022610	138	0.012
outflow tract morphogenesis	GO:0003151	4	0.012
cell proliferation	GO:0008283	299	0.012
camp metabolic process	GO:0046058	19	0.012
synaptic transmission	GO:0007268	288	0.012
cellular response to growth factor stimulus	GO:0071363	30	0.012
pattern recognition receptor signaling pathway	GO:0002221	2	0.012
wound healing spreading of epidermal cells	GO:0035313	1	0.012
regulation of cellular amine metabolic process	GO:0033238	3	0.012
protein import into nucleus	GO:0006606	51	0.012
nephron tubule development	GO:0072080	3	0.012
protein processing	GO:0016485	68	0.012
cellular response to nitrogen compound	GO:1901699	51	0.012
cell fate determination	GO:0001709	91	0.012
circadian behavior	GO:0048512	76	0.012	Fly
regulation of r7 cell differentiation	GO:0045676	15	0.012
developmental pigmentation	GO:0048066	68	0.012
wing disc morphogenesis	GO:0007472	344	0.012	Fly
organonitrogen compound biosynthetic process	GO:1901566	117	0.012
social behavior	GO:0035176	4	0.012
regulation of defense response	GO:0031347	102	0.012
adult locomotory behavior	GO:0008344	76	0.011
molting cycle process	GO:0022404	29	0.011
appendage segmentation	GO:0035285	26	0.011
cellular response to organic substance	GO:0071310	132	0.011	Fly
epithelial cell proliferation	GO:0050673	15	0.011
pharynx development	GO:0060465	1	0.011
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.011
oxoacid metabolic process	GO:0043436	103	0.011
cell adhesion	GO:0007155	136	0.011
actin cytoskeleton organization	GO:0030036	206	0.011
neuron recognition	GO:0008038	101	0.011
imaginal disc derived leg segmentation	GO:0036011	26	0.011
cellular macromolecular complex assembly	GO:0034622	153	0.011
imaginal disc derived wing vein specification	GO:0007474	48	0.011
regulation of tube architecture open tracheal system	GO:0035152	68	0.011
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.011
wnt signaling pathway	GO:0016055	98	0.011
embryonic hindgut morphogenesis	GO:0048619	48	0.011
cellular lipid catabolic process	GO:0044242	16	0.011
negative regulation of cell death	GO:0060548	81	0.010
nephron development	GO:0072006	3	0.010
mrna processing	GO:0006397	104	0.010
carboxylic acid metabolic process	GO:0019752	92	0.010
mesoderm development	GO:0007498	78	0.010
telencephalon development	GO:0021537	2	0.010
aromatic compound catabolic process	GO:0019439	166	0.010
protein transport	GO:0015031	155	0.010
response to oxygen levels	GO:0070482	59	0.010
gene silencing by rna	GO:0031047	57	0.010
spermatid differentiation	GO:0048515	114	0.010
growth	GO:0040007	359	0.010	Worm Fly
posttranscriptional gene silencing by rna	GO:0035194	45	0.010
neuromuscular process	GO:0050905	21	0.010
regulation of multicellular organismal development	GO:2000026	414	0.010	Fly

dsf disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.075
urinary system disease	DOID:18	0.075
kidney disease	DOID:557	0.012
disease of metabolism	DOID:0014667	0.011

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