IMP: Integrative Multi-species Prediction

Drosophila melanogaster

37 known processes

Trx-2 (Dmel_CG31884)

thioredoxin-2

(Aliases: dmtrx-2,DmelTrx-2,Dmel\CG31884,anon-WO0118547.188,31884,DmTrx-2,CG31884,CG3864)

Entrez: 34281
FLYBASE: FBgn0040070
UniProtKB: D3DMZ9
UniProtKB: Q9V429

Process Predictions
Disease Predictions

Trx-2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
response to oxidative stress	GO:0006979	86	0.998
response to oxygen radical	GO:0000305	3	0.940
cellular response to oxidative stress	GO:0034599	28	0.833
immune response	GO:0006955	246	0.778
response to abiotic stimulus	GO:0009628	341	0.756
negative regulation of cellular metabolic process	GO:0031324	382	0.694
response to reactive oxygen species	GO:0000302	24	0.673
cellular response to reactive oxygen species	GO:0034614	14	0.651
immune system process	GO:0002376	347	0.636
defense response to other organism	GO:0098542	225	0.620
response to oxygen containing compound	GO:1901700	200	0.611
response to bacterium	GO:0009617	198	0.611
organonitrogen compound metabolic process	GO:1901564	318	0.593
intracellular signal transduction	GO:0035556	300	0.560
response to external biotic stimulus	GO:0043207	293	0.555
regulation of immune system process	GO:0002682	176	0.512
peptide metabolic process	GO:0006518	80	0.502
single organism behavior	GO:0044708	391	0.459
regulation of immune response	GO:0050776	118	0.457
response to endogenous stimulus	GO:0009719	119	0.457
defense response	GO:0006952	300	0.405
regulation of cell death	GO:0010941	173	0.398
catabolic process	GO:0009056	409	0.393
response to biotic stimulus	GO:0009607	294	0.391
determination of adult lifespan	GO:0008340	137	0.370
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.367
regulation of response to stress	GO:0080134	200	0.354
negative regulation of rna metabolic process	GO:0051253	251	0.342
positive regulation of response to stimulus	GO:0048584	323	0.335
regulation of multi organism process	GO:0043900	131	0.332
response to superoxide	GO:0000303	3	0.330
death	GO:0016265	284	0.322
carboxylic acid metabolic process	GO:0019752	92	0.315
negative regulation of response to stimulus	GO:0048585	258	0.310
response to other organism	GO:0051707	293	0.305
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.302
hydrogen peroxide catabolic process	GO:0042744	6	0.300
negative regulation of rna biosynthetic process	GO:1902679	240	0.289
transcription from rna polymerase ii promoter	GO:0006366	368	0.286
cellular response to extracellular stimulus	GO:0031668	64	0.285
response to organic substance	GO:0010033	284	0.281
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.269
regulation of response to external stimulus	GO:0032101	115	0.269
small molecule metabolic process	GO:0044281	305	0.268
cell death	GO:0008219	279	0.268
defense response to bacterium	GO:0042742	178	0.249
negative regulation of transcription dna templated	GO:0045892	237	0.246
cellular amide metabolic process	GO:0043603	80	0.246
regulation of defense response	GO:0031347	102	0.245
response to temperature stimulus	GO:0009266	106	0.240
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.231
cellular response to oxygen containing compound	GO:1901701	79	0.228
programmed cell death	GO:0012501	257	0.218
pigment metabolic process	GO:0042440	84	0.215
cell proliferation	GO:0008283	299	0.212
positive regulation of intracellular signal transduction	GO:1902533	116	0.210
response to extracellular stimulus	GO:0009991	116	0.208
aging	GO:0007568	143	0.207
innate immune response	GO:0045087	144	0.191
response to heat	GO:0009408	63	0.182
cellular amino acid metabolic process	GO:0006520	61	0.174
central nervous system development	GO:0007417	201	0.165
paracrine signaling	GO:0038001	7	0.164
cellular protein modification process	GO:0006464	438	0.163
reactive oxygen species metabolic process	GO:0072593	22	0.162
response to hydrogen peroxide	GO:0042542	11	0.161
response to radiation	GO:0009314	155	0.158
regulation of multicellular organismal development	GO:2000026	414	0.155
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.150
establishment of localization in cell	GO:0051649	402	0.150
regulation of phosphorylation	GO:0042325	147	0.147
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.143
gland development	GO:0048732	191	0.142
appendage development	GO:0048736	401	0.138
amine metabolic process	GO:0009308	12	0.136
positive regulation of cell communication	GO:0010647	250	0.133
endocytosis	GO:0006897	310	0.131
regulation of cell proliferation	GO:0042127	163	0.131
aromatic compound catabolic process	GO:0019439	166	0.129
regulation of response to biotic stimulus	GO:0002831	63	0.122
regulation of molecular function	GO:0065009	217	0.121
cellular response to chemical stimulus	GO:0070887	199	0.120
nuclear dna replication	GO:0033260	1	0.120
regulation of intracellular signal transduction	GO:1902531	236	0.119
regulation of protein metabolic process	GO:0051246	256	0.117
response to axon injury	GO:0048678	12	0.116
positive regulation of signal transduction	GO:0009967	223	0.115
pigmentation	GO:0043473	75	0.113
intrinsic apoptotic signaling pathway	GO:0097193	16	0.113
developmental growth	GO:0048589	280	0.109
behavioral response to ethanol	GO:0048149	49	0.106
regulation of anatomical structure size	GO:0090066	163	0.103
negative regulation of cell communication	GO:0010648	223	0.102
response to metal ion	GO:0010038	23	0.102
regulation of apoptotic process	GO:0042981	130	0.100
regulation of anatomical structure morphogenesis	GO:0022603	242	0.098
phosphorylation	GO:0016310	294	0.095
intracellular transport	GO:0046907	228	0.095
immune response activating signal transduction	GO:0002757	2	0.094
homeostatic process	GO:0042592	199	0.093
positive regulation of biosynthetic process	GO:0009891	316	0.093
apoptotic signaling pathway	GO:0097190	27	0.092
positive regulation of cellular biosynthetic process	GO:0031328	316	0.091
regulation of cellular protein metabolic process	GO:0032268	243	0.091
negative regulation of biosynthetic process	GO:0009890	277	0.091
developmental pigmentation	GO:0048066	68	0.088
cellular nitrogen compound catabolic process	GO:0044270	165	0.088
cellular response to endogenous stimulus	GO:0071495	80	0.087
positive regulation of signaling	GO:0023056	243	0.086
taxis	GO:0042330	304	0.086
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.086
regulation of catabolic process	GO:0009894	170	0.085
negative regulation of defense response	GO:0031348	35	0.085
cellular response to dna damage stimulus	GO:0006974	223	0.085
cellular response to nutrient levels	GO:0031669	62	0.084
rna processing	GO:0006396	147	0.084
negative regulation of gene expression	GO:0010629	387	0.083
response to inorganic substance	GO:0010035	44	0.082
single organism biosynthetic process	GO:0044711	206	0.082
brain development	GO:0007420	120	0.081
negative regulation of signal transduction	GO:0009968	206	0.080
regulation of cell differentiation	GO:0045595	302	0.077
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.075
muscle structure development	GO:0061061	224	0.074
response to nutrient levels	GO:0031667	114	0.074
cellular modified amino acid metabolic process	GO:0006575	45	0.073
vesicle mediated transport	GO:0016192	381	0.070
head development	GO:0060322	135	0.070	Fly
carbohydrate derivative metabolic process	GO:1901135	217	0.069
single organism intracellular transport	GO:1902582	207	0.069
cell adhesion	GO:0007155	136	0.069
negative regulation of molecular function	GO:0044092	51	0.065
regulation of mapk cascade	GO:0043408	92	0.065
regulation of cellular response to stress	GO:0080135	89	0.065
phagocytosis	GO:0006909	215	0.063
organonitrogen compound biosynthetic process	GO:1901566	117	0.063
negative regulation of signaling	GO:0023057	219	0.063
oxoacid metabolic process	GO:0043436	103	0.062
regulation of developmental growth	GO:0048638	174	0.062
nucleoside catabolic process	GO:0009164	112	0.061
cellular response to organic substance	GO:0071310	132	0.060
cellular response to external stimulus	GO:0071496	66	0.060
regulation of cellular amine metabolic process	GO:0033238	3	0.060
organic acid metabolic process	GO:0006082	103	0.059
regulation of programmed cell death	GO:0043067	152	0.058
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.057
developmental programmed cell death	GO:0010623	138	0.057
defense response to gram negative bacterium	GO:0050829	94	0.057
humoral immune response	GO:0006959	117	0.057
growth	GO:0040007	359	0.056
biological adhesion	GO:0022610	138	0.056
cytoplasmic transport	GO:0016482	130	0.056
organophosphate metabolic process	GO:0019637	195	0.055
tissue death	GO:0016271	102	0.054
signal transduction by phosphorylation	GO:0023014	107	0.053
single organism catabolic process	GO:0044712	228	0.052
negative regulation of protein metabolic process	GO:0051248	85	0.051
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.051
epidermal cell differentiation	GO:0009913	51	0.051
response to starvation	GO:0042594	97	0.050
neurological system process	GO:0050877	358	0.050
positive regulation of gene expression	GO:0010628	290	0.050
glycosyl compound metabolic process	GO:1901657	127	0.049
protein phosphorylation	GO:0006468	169	0.049
exocrine system development	GO:0035272	162	0.048
cellular amine metabolic process	GO:0044106	12	0.048
regulation of antimicrobial peptide production	GO:0002784	44	0.048
regulation of autophagy	GO:0010506	62	0.046
positive regulation of immune system process	GO:0002684	68	0.045
positive regulation of rna biosynthetic process	GO:1902680	266	0.045
negative regulation of multicellular organismal process	GO:0051241	142	0.044
negative regulation of programmed cell death	GO:0043069	72	0.044
negative regulation of cell death	GO:0060548	81	0.044
carbohydrate metabolic process	GO:0005975	82	0.044
activation of innate immune response	GO:0002218	4	0.043
nucleotide metabolic process	GO:0009117	161	0.043
response to wounding	GO:0009611	94	0.043
organonitrogen compound catabolic process	GO:1901565	128	0.042
positive regulation of protein metabolic process	GO:0051247	128	0.042
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.042
cellular response to hydrogen peroxide	GO:0070301	7	0.041
protein localization	GO:0008104	284	0.041
purine containing compound metabolic process	GO:0072521	155	0.041
maintenance of location	GO:0051235	73	0.040
negative regulation of cellular biosynthetic process	GO:0031327	277	0.040
regulation of phosphate metabolic process	GO:0019220	210	0.039
response to cadmium ion	GO:0046686	9	0.039
cellular catabolic process	GO:0044248	372	0.039
nucleotide catabolic process	GO:0009166	109	0.039
regulation of catalytic activity	GO:0050790	185	0.038
regulation of antimicrobial humoral response	GO:0002759	50	0.038
mapk cascade	GO:0000165	107	0.038
organic substance transport	GO:0071702	257	0.037
nucleocytoplasmic transport	GO:0006913	72	0.037
regulation of phosphorus metabolic process	GO:0051174	210	0.037
multicellular organismal aging	GO:0010259	140	0.036
purine containing compound catabolic process	GO:0072523	112	0.036
regulation of humoral immune response	GO:0002920	51	0.036
regulation of protein modification process	GO:0031399	112	0.036
negative regulation of apoptotic process	GO:0043066	63	0.035
positive regulation of immune response	GO:0050778	63	0.034
positive regulation of macromolecule metabolic process	GO:0010604	405	0.033
positive regulation of innate immune response	GO:0045089	38	0.033
response to light stimulus	GO:0009416	124	0.032
regulation of multicellular organism growth	GO:0040014	40	0.032
negative regulation of catalytic activity	GO:0043086	42	0.032
multicellular organism growth	GO:0035264	46	0.031
protein complex assembly	GO:0006461	200	0.031
embryonic development via the syncytial blastoderm	GO:0001700	148	0.031
immune response regulating signaling pathway	GO:0002764	2	0.031
localization of cell	GO:0051674	257	0.031
positive regulation of cell migration	GO:0030335	2	0.030
muscle organ development	GO:0007517	127	0.030
glutathione metabolic process	GO:0006749	37	0.030
nucleoside phosphate catabolic process	GO:1901292	110	0.030
response to organonitrogen compound	GO:0010243	75	0.030
purine ribonucleotide catabolic process	GO:0009154	109	0.029
regulation of protein stability	GO:0031647	43	0.029
protein modification process	GO:0036211	438	0.029
cell aging	GO:0007569	2	0.029
oocyte development	GO:0048599	124	0.029
response to ethanol	GO:0045471	59	0.029
histolysis	GO:0007559	102	0.028
gland morphogenesis	GO:0022612	145	0.028
organic substance catabolic process	GO:1901575	308	0.028
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.028
establishment of protein localization to organelle	GO:0072594	62	0.027
apoptotic process	GO:0006915	159	0.027
regulation of hydrolase activity	GO:0051336	97	0.027
positive regulation of multicellular organismal process	GO:0051240	143	0.026
nucleobase containing small molecule metabolic process	GO:0055086	174	0.026
regulation of protein phosphorylation	GO:0001932	64	0.026
cellular response to starvation	GO:0009267	61	0.026
regulation of cell morphogenesis	GO:0022604	163	0.026
anatomical structure homeostasis	GO:0060249	97	0.026
regulation of cell development	GO:0060284	215	0.025
response to alcohol	GO:0097305	95	0.025
positive regulation of defense response	GO:0031349	59	0.025
positive regulation of transcription dna templated	GO:0045893	266	0.025
regulation of cellular response to oxidative stress	GO:1900407	4	0.025
cellular homeostasis	GO:0019725	80	0.024
cellular response to metal ion	GO:0071248	6	0.024
positive regulation of developmental process	GO:0051094	143	0.024
purine ribonucleotide metabolic process	GO:0009150	145	0.024
positive regulation of mapk cascade	GO:0043410	63	0.024
innate immune response activating signal transduction	GO:0002758	2	0.024
protein targeting	GO:0006605	64	0.024
organic cyclic compound catabolic process	GO:1901361	168	0.023
ameboidal type cell migration	GO:0001667	151	0.023
regulation of cellular ketone metabolic process	GO:0010565	3	0.023
regulation of innate immune response	GO:0045088	71	0.023
covalent chromatin modification	GO:0016569	106	0.022
response to fungus	GO:0009620	50	0.022
salivary gland histolysis	GO:0035070	88	0.022
regulation of terminal button organization	GO:2000331	11	0.022
positive regulation of response to external stimulus	GO:0032103	44	0.022
cellular response to cadmium ion	GO:0071276	6	0.022
purine nucleotide metabolic process	GO:0006163	146	0.022
purine nucleotide catabolic process	GO:0006195	109	0.021
single organism cellular localization	GO:1902580	180	0.021
regulation of transferase activity	GO:0051338	58	0.021
nuclear transport	GO:0051169	72	0.021
nucleoside phosphate metabolic process	GO:0006753	162	0.020
response to cold	GO:0009409	13	0.020
salivary gland morphogenesis	GO:0007435	145	0.020
cognition	GO:0050890	141	0.020
dephosphorylation	GO:0016311	51	0.020
chemotaxis	GO:0006935	249	0.020
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.019
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.019
regulation of protein kinase activity	GO:0045859	51	0.019
negative regulation of developmental process	GO:0051093	201	0.019
heterocycle catabolic process	GO:0046700	166	0.019
tissue morphogenesis	GO:0048729	297	0.019
regulation of cellular catabolic process	GO:0031329	157	0.019
lipid metabolic process	GO:0006629	121	0.018
regulation of cytoplasmic transport	GO:1903649	47	0.018
response to nitrogen compound	GO:1901698	90	0.018
cellular macromolecule localization	GO:0070727	220	0.018
regulation of nervous system development	GO:0051960	248	0.018
intracellular protein transport	GO:0006886	104	0.018
positive regulation of cell size	GO:0045793	21	0.018
negative regulation of cell differentiation	GO:0045596	143	0.018
chromatin organization	GO:0006325	207	0.018
salivary gland cell autophagic cell death	GO:0035071	83	0.017
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.017
stress activated protein kinase signaling cascade	GO:0031098	55	0.017
cation transport	GO:0006812	110	0.017
positive regulation of cellular protein metabolic process	GO:0032270	118	0.017
skin development	GO:0043588	65	0.017
post embryonic appendage morphogenesis	GO:0035120	385	0.017
appendage morphogenesis	GO:0035107	397	0.017
response to lipopolysaccharide	GO:0032496	4	0.016
sprouting of injured axon	GO:0048682	3	0.016
muscle tissue morphogenesis	GO:0060415	2	0.016
ribonucleotide metabolic process	GO:0009259	145	0.016
actin cytoskeleton organization	GO:0030036	206	0.016
positive regulation of cell proliferation	GO:0008284	47	0.016
immune system development	GO:0002520	57	0.016
positive regulation of cell motility	GO:2000147	3	0.016
establishment or maintenance of cell polarity	GO:0007163	167	0.016
negative regulation of cellular component organization	GO:0051129	108	0.016
peptidyl amino acid modification	GO:0018193	105	0.016
actin filament based process	GO:0030029	220	0.015
cellular ketone metabolic process	GO:0042180	24	0.015
positive regulation of phosphorus metabolic process	GO:0010562	139	0.015
ribonucleotide catabolic process	GO:0009261	109	0.015
positive regulation of rna metabolic process	GO:0051254	271	0.015
macromolecule catabolic process	GO:0009057	161	0.015
protein transport	GO:0015031	155	0.015
secondary metabolic process	GO:0019748	75	0.015
regulation of behavior	GO:0050795	75	0.015
positive regulation of catalytic activity	GO:0043085	118	0.015
cellular response to organonitrogen compound	GO:0071417	36	0.015
salivary gland development	GO:0007431	162	0.015
negative regulation of immune system process	GO:0002683	50	0.015
release of sequestered calcium ion into cytosol	GO:0051209	1	0.014
cell motility	GO:0048870	251	0.014
divalent metal ion transport	GO:0070838	26	0.014
regulation of cellular localization	GO:0060341	136	0.014
organic hydroxy compound metabolic process	GO:1901615	83	0.014
single organism carbohydrate metabolic process	GO:0044723	72	0.014
striated muscle cell differentiation	GO:0051146	90	0.014
negative regulation of sequestering of calcium ion	GO:0051283	2	0.014
eye development	GO:0001654	323	0.014
defense response to fungus	GO:0050832	48	0.014
establishment of protein localization	GO:0045184	163	0.014
long term memory	GO:0007616	62	0.014
protein targeting to nucleus	GO:0044744	51	0.014
autophagic cell death	GO:0048102	83	0.014
carbohydrate derivative catabolic process	GO:1901136	118	0.014
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.014
cell migration	GO:0016477	238	0.013
positive regulation of defense response to bacterium	GO:1900426	23	0.013
purine ribonucleoside metabolic process	GO:0046128	127	0.013
cellular protein localization	GO:0034613	160	0.013
negative regulation of intracellular signal transduction	GO:1902532	57	0.013
regulation of cellular amino acid metabolic process	GO:0006521	0	0.013
developmental maturation	GO:0021700	172	0.013
organ or tissue specific immune response	GO:0002251	10	0.013
regulation of sequestering of calcium ion	GO:0051282	3	0.013
posttranscriptional regulation of gene expression	GO:0010608	145	0.013
protein complex biogenesis	GO:0070271	201	0.013
muscle tissue development	GO:0060537	30	0.013
cytosolic calcium ion transport	GO:0060401	2	0.013
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.012
regulation of adult chitin containing cuticle pigmentation	GO:0048082	13	0.012
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.012
nucleobase containing compound catabolic process	GO:0034655	165	0.012
single organism cell adhesion	GO:0098602	47	0.012
sensory perception	GO:0007600	196	0.012
antimicrobial humoral response	GO:0019730	99	0.012
hematopoietic or lymphoid organ development	GO:0048534	57	0.012
regulation of dna templated transcription in response to stress	GO:0043620	4	0.012
chemical homeostasis	GO:0048878	92	0.011
cellular protein complex assembly	GO:0043623	71	0.011
regulation of neurogenesis	GO:0050767	158	0.011
heart morphogenesis	GO:0003007	32	0.011
embryo development ending in birth or egg hatching	GO:0009792	152	0.011
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.011
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.011
response to water deprivation	GO:0009414	4	0.011
ribose phosphate metabolic process	GO:0019693	145	0.011
left right axis specification	GO:0070986	1	0.011
cellular response to hormone stimulus	GO:0032870	44	0.011
cell type specific apoptotic process	GO:0097285	38	0.011
methylation	GO:0032259	47	0.011
negative regulation of protein phosphorylation	GO:0001933	17	0.011
stress activated mapk cascade	GO:0051403	52	0.011
positive regulation of nuclear division	GO:0051785	14	0.011
epithelial cell differentiation	GO:0030855	322	0.010
positive regulation of apoptotic process	GO:0043065	47	0.010
regulation of jnk cascade	GO:0046328	40	0.010
regulation of proteolysis	GO:0030162	87	0.010
intracellular receptor signaling pathway	GO:0030522	19	0.010
cell cycle checkpoint	GO:0000075	95	0.010
protein localization to organelle	GO:0033365	82	0.010
positive regulation of phosphorylation	GO:0042327	87	0.010
cell activation	GO:0001775	9	0.010
response to organic cyclic compound	GO:0014070	89	0.010
response to hormone	GO:0009725	45	0.010
negative regulation of innate immune response	GO:0045824	30	0.010
cellular response to inorganic substance	GO:0071241	8	0.010
wing disc morphogenesis	GO:0007472	344	0.010

Trx-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.090
	disease of cellular proliferation	DOID:14566	0	0.011

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