IMP: Integrative Multi-species Prediction

Drosophila melanogaster

14 known processes

Hex-A (Dmel_CG3001)

Hexokinase A

(Aliases: HEX-A,HK,Hex,HEX,Hex-A:B,Dmel\CG3001,DM1,CG3001)

FLYBASE: FBgn0001186
Entrez: 45875
UniProtKB: Q9GNH8
UniProtKB: Q9W330

Process Predictions
Disease Predictions

Hex-A biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
lateral inhibition	GO:0046331	206	0.198	Fly
neurological system process	GO:0050877	358	0.153
regulation of cell cycle process	GO:0010564	181	0.137
regulation of cell cycle	GO:0051726	291	0.092
meiotic cell cycle process	GO:1903046	132	0.090
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.086	Fly
macromolecular complex assembly	GO:0065003	256	0.078
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.078	Human
appendage development	GO:0048736	401	0.075
epithelial cell differentiation	GO:0030855	322	0.075
oxidoreduction coenzyme metabolic process	GO:0006733	2	0.073	Mouse
organonitrogen compound metabolic process	GO:1901564	318	0.073	Mouse
nad metabolic process	GO:0019674	1	0.065
posttranscriptional gene silencing	GO:0016441	46	0.064
endocytosis	GO:0006897	310	0.063
ovarian follicle cell development	GO:0030707	248	0.062
eye development	GO:0001654	323	0.061
regulation of growth	GO:0040008	233	0.061
regulation of multicellular organismal development	GO:2000026	414	0.060
localization of cell	GO:0051674	257	0.060
regulation of cell death	GO:0010941	173	0.057
gene silencing	GO:0016458	138	0.057
negative regulation of rna biosynthetic process	GO:1902679	240	0.057
single organism catabolic process	GO:0044712	228	0.057	Yeast
positive regulation of rna metabolic process	GO:0051254	271	0.056
organic cyclic compound catabolic process	GO:1901361	168	0.056
positive regulation of cellular biosynthetic process	GO:0031328	316	0.055	Human
nicotinamide nucleotide metabolic process	GO:0046496	2	0.055	Mouse
organic substance catabolic process	GO:1901575	308	0.054	Yeast
developmental growth	GO:0048589	280	0.054
pigmentation	GO:0043473	75	0.053
response to lipopolysaccharide	GO:0032496	4	0.051
organelle fission	GO:0048285	340	0.051
cell cell junction organization	GO:0045216	55	0.051
columnar cuboidal epithelial cell development	GO:0002066	249	0.051
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.050
regulation of transport	GO:0051049	181	0.050	Human Mouse
small molecule metabolic process	GO:0044281	305	0.050	Human Yeast Mouse
nuclear division	GO:0000280	332	0.050
aromatic compound catabolic process	GO:0019439	166	0.049
actin cytoskeleton organization	GO:0030036	206	0.049
nucleoside phosphate metabolic process	GO:0006753	162	0.049	Mouse
intracellular signal transduction	GO:0035556	300	0.047
cellular ketone metabolic process	GO:0042180	24	0.047	Human
negative regulation of gene expression	GO:0010629	387	0.047
programmed cell death	GO:0012501	257	0.047	Mouse
epithelial cell development	GO:0002064	274	0.047
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.046
cell motility	GO:0048870	251	0.046
chemotaxis	GO:0006935	249	0.046
positive regulation of macromolecule metabolic process	GO:0010604	405	0.046	Human
positive regulation of cell communication	GO:0010647	250	0.045	Human Mouse
response to oxygen containing compound	GO:1901700	200	0.044	Human
organonitrogen compound catabolic process	GO:1901565	128	0.044
phagocytosis	GO:0006909	215	0.044
cellular amino acid metabolic process	GO:0006520	61	0.044
cell proliferation	GO:0008283	299	0.043
notch signaling pathway	GO:0007219	120	0.043
hindbrain development	GO:0030902	2	0.042
mitotic nuclear division	GO:0007067	213	0.041
camera type eye development	GO:0043010	4	0.041
growth	GO:0040007	359	0.040
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.040
regulation of programmed cell death	GO:0043067	152	0.040
nadh metabolic process	GO:0006734	1	0.039
transcription from rna polymerase ii promoter	GO:0006366	368	0.038
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.038
epidermis development	GO:0008544	65	0.037
negative regulation of cell proliferation	GO:0008285	69	0.036
embryo development ending in birth or egg hatching	GO:0009792	152	0.036
axon development	GO:0061564	297	0.036
appendage morphogenesis	GO:0035107	397	0.036
vesicle mediated transport	GO:0016192	381	0.036
imaginal disc derived appendage development	GO:0048737	399	0.035
negative regulation of cell cycle	GO:0045786	116	0.035
regionalization	GO:0003002	416	0.035
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.034
single organism biosynthetic process	GO:0044711	206	0.034	Human
retina development in camera type eye	GO:0060041	4	0.034
cell junction organization	GO:0034330	57	0.034
negative regulation of multicellular organismal process	GO:0051241	142	0.034
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.033
glutamate metabolic process	GO:0006536	5	0.033
positive regulation of transcription dna templated	GO:0045893	266	0.033
nephron development	GO:0072006	3	0.033
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.032
cellular nitrogen compound catabolic process	GO:0044270	165	0.032
epithelial cell migration	GO:0010631	148	0.032
cell migration	GO:0016477	238	0.032
response to bacterium	GO:0009617	198	0.032
regulation of intracellular signal transduction	GO:1902531	236	0.031
response to alcohol	GO:0097305	95	0.031
kidney development	GO:0001822	3	0.031
wing disc morphogenesis	GO:0007472	344	0.031
detection of light stimulus	GO:0009583	58	0.030
response to light stimulus	GO:0009416	124	0.030
organic acid metabolic process	GO:0006082	103	0.030	Yeast
regulation of cellular ketone metabolic process	GO:0010565	3	0.029	Human
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.029
catabolic process	GO:0009056	409	0.029	Yeast
carboxylic acid metabolic process	GO:0019752	92	0.029	Yeast
sensory perception	GO:0007600	196	0.028
regulation of apoptotic process	GO:0042981	130	0.028
energy derivation by oxidation of organic compounds	GO:0015980	32	0.028	Human
regulation of phosphate metabolic process	GO:0019220	210	0.028
meiotic nuclear division	GO:0007126	151	0.028
negative regulation of cell cycle process	GO:0010948	109	0.028
imaginal disc derived wing morphogenesis	GO:0007476	337	0.027
axonogenesis	GO:0007409	290	0.027
cell adhesion	GO:0007155	136	0.027
actin filament based process	GO:0030029	220	0.027
positive regulation of signaling	GO:0023056	243	0.027	Human Mouse
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.027
nucleobase containing small molecule metabolic process	GO:0055086	174	0.027	Mouse
oxoacid metabolic process	GO:0043436	103	0.026	Yeast
morphogenesis of an epithelium	GO:0002009	276	0.026
regulation of cell development	GO:0060284	215	0.026
amine metabolic process	GO:0009308	12	0.026
negative regulation of transcription dna templated	GO:0045892	237	0.026
positive regulation of cell death	GO:0010942	69	0.025
heterocycle catabolic process	GO:0046700	166	0.025
regulation of cellular localization	GO:0060341	136	0.024	Human Mouse
axon guidance	GO:0007411	233	0.024
carbohydrate biosynthetic process	GO:0016051	17	0.024	Human
stem cell proliferation	GO:0072089	88	0.024
oxidation reduction process	GO:0055114	123	0.024	Human
cellular protein modification process	GO:0006464	438	0.024
purine nucleotide catabolic process	GO:0006195	109	0.023
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.023
regulation of cell cycle phase transition	GO:1901987	130	0.023
negative regulation of cellular biosynthetic process	GO:0031327	277	0.023	Human
hair cell differentiation	GO:0035315	47	0.023
response to radiation	GO:0009314	155	0.023
cellular response to dna damage stimulus	GO:0006974	223	0.023
cell junction assembly	GO:0034329	42	0.023
dorsal ventral pattern formation	GO:0009953	133	0.023
regulation of notch signaling pathway	GO:0008593	100	0.023
meiotic cell cycle	GO:0051321	171	0.023
ras protein signal transduction	GO:0007265	88	0.023
forebrain development	GO:0030900	2	0.023
cellular catabolic process	GO:0044248	372	0.023
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.022
positive regulation of gene expression	GO:0010628	290	0.022
rna localization	GO:0006403	115	0.022
detection of stimulus	GO:0051606	156	0.022	Human
brain development	GO:0007420	120	0.022
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.022
tissue morphogenesis	GO:0048729	297	0.022
telencephalon development	GO:0021537	2	0.022
negative regulation of mitotic cell cycle	GO:0045930	109	0.022
nucleobase containing compound catabolic process	GO:0034655	165	0.022
regulation of protein metabolic process	GO:0051246	256	0.022
regulation of oocyte development	GO:0060281	27	0.022
body morphogenesis	GO:0010171	2	0.021
post embryonic appendage morphogenesis	GO:0035120	385	0.021
death	GO:0016265	284	0.021	Mouse
protein modification process	GO:0036211	438	0.021
negative regulation of biosynthetic process	GO:0009890	277	0.021	Human
ameboidal type cell migration	GO:0001667	151	0.021
epidermal cell differentiation	GO:0009913	51	0.020
positive regulation of multicellular organismal process	GO:0051240	143	0.020
central nervous system development	GO:0007417	201	0.020
regulation of mitotic cell cycle	GO:0007346	190	0.020
single organism behavior	GO:0044708	391	0.020
response to other organism	GO:0051707	293	0.020
sensory organ morphogenesis	GO:0090596	260	0.020
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.020
response to monosaccharide	GO:0034284	4	0.020	Human
homeostatic process	GO:0042592	199	0.020	Human Mouse
apoptotic process	GO:0006915	159	0.020	Mouse
negative regulation of cell differentiation	GO:0045596	143	0.020
regulation of cell differentiation	GO:0045595	302	0.020
dna metabolic process	GO:0006259	227	0.020
phosphorylation	GO:0016310	294	0.020
positive regulation of developmental process	GO:0051094	143	0.020
positive regulation of cell migration	GO:0030335	2	0.019
positive regulation of cellular protein metabolic process	GO:0032270	118	0.019
synaptic target recognition	GO:0008039	45	0.019
cellular component assembly involved in morphogenesis	GO:0010927	151	0.019
skin development	GO:0043588	65	0.019
taxis	GO:0042330	304	0.019
positive regulation of phosphorus metabolic process	GO:0010562	139	0.019
regulation of phosphorus metabolic process	GO:0051174	210	0.019
metal ion transport	GO:0030001	74	0.019	Mouse
posttranscriptional gene silencing by rna	GO:0035194	45	0.019
epithelial tube morphogenesis	GO:0060562	88	0.019
regulation of epithelial cell differentiation	GO:0030856	4	0.018
mitotic spindle organization	GO:0007052	220	0.018
heart morphogenesis	GO:0003007	32	0.018
positive regulation of phosphate metabolic process	GO:0045937	139	0.018
gliogenesis	GO:0042063	80	0.018
nephron epithelium development	GO:0072009	3	0.018
neuronal action potential	GO:0019228	10	0.018
regulation of cell proliferation	GO:0042127	163	0.018
open tracheal system development	GO:0007424	204	0.018
purine ribonucleotide metabolic process	GO:0009150	145	0.018
positive regulation of cellular component biogenesis	GO:0044089	80	0.018
smoothened signaling pathway	GO:0007224	49	0.018
small gtpase mediated signal transduction	GO:0007264	88	0.018
neuroblast proliferation	GO:0007405	74	0.017
acetylcholine metabolic process	GO:0008291	2	0.017
nitrogen compound transport	GO:0071705	85	0.017	Human Mouse
regulation of localization	GO:0032879	275	0.017	Human Mouse
alpha amino acid metabolic process	GO:1901605	20	0.017
choline catabolic process	GO:0042426	1	0.017
positive regulation of catabolic process	GO:0009896	105	0.017
cellular macromolecule catabolic process	GO:0044265	136	0.017
ribonucleotide catabolic process	GO:0009261	109	0.017
single organism cell adhesion	GO:0098602	47	0.017
detection of stimulus involved in sensory perception	GO:0050906	92	0.017
response to organic cyclic compound	GO:0014070	89	0.017
carbohydrate derivative metabolic process	GO:1901135	217	0.017	Human Yeast Mouse
regulation of gene expression epigenetic	GO:0040029	128	0.017
positive regulation of cell motility	GO:2000147	3	0.016
purine containing compound catabolic process	GO:0072523	112	0.016
regulation of cellular amine metabolic process	GO:0033238	3	0.016
posttranscriptional regulation of gene expression	GO:0010608	145	0.016
cell cell junction assembly	GO:0007043	38	0.016
detection of external stimulus	GO:0009581	66	0.016
memory	GO:0007613	94	0.016
ribose phosphate metabolic process	GO:0019693	145	0.016
gene silencing by rna	GO:0031047	57	0.016
cell division	GO:0051301	248	0.016
neuron projection guidance	GO:0097485	241	0.016
heart development	GO:0007507	82	0.016
response to endogenous stimulus	GO:0009719	119	0.016
carbohydrate metabolic process	GO:0005975	82	0.016
regulation of mapk cascade	GO:0043408	92	0.015
cellular response to organic substance	GO:0071310	132	0.015
chromosome organization	GO:0051276	360	0.015
positive regulation of biosynthetic process	GO:0009891	316	0.015	Human
establishment of blood nerve barrier	GO:0008065	2	0.015
ribonucleotide metabolic process	GO:0009259	145	0.015
epithelium migration	GO:0090132	148	0.015
imaginal disc derived wing hair organization	GO:0035317	45	0.015
wound healing	GO:0042060	75	0.015
negative regulation of cell cycle phase transition	GO:1901988	103	0.015
pyridine containing compound metabolic process	GO:0072524	3	0.015	Mouse
non sensory hair organization	GO:0035316	47	0.015
imaginal disc pattern formation	GO:0007447	91	0.015
regulation of organelle organization	GO:0033043	196	0.015
cellular response to chemical stimulus	GO:0070887	199	0.014
organophosphate metabolic process	GO:0019637	195	0.014	Human Yeast Mouse
nucleobase containing compound transport	GO:0015931	56	0.014
positive regulation of programmed cell death	GO:0043068	62	0.014
regulation of steroid metabolic process	GO:0019218	2	0.014
chaeta development	GO:0022416	97	0.014
positive regulation of response to stimulus	GO:0048584	323	0.014
positive regulation of transport	GO:0051050	92	0.014	Human Mouse
anatomical structure homeostasis	GO:0060249	97	0.014
positive regulation of lipid metabolic process	GO:0045834	4	0.014
deactivation of rhodopsin mediated signaling	GO:0016059	17	0.014
acyl coa metabolic process	GO:0006637	3	0.014
positive regulation of organelle organization	GO:0010638	65	0.014
nucleoside phosphate catabolic process	GO:1901292	110	0.014
response to organic substance	GO:0010033	284	0.014	Human
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.014
response to hexose	GO:0009746	3	0.014	Human
larval development	GO:0002164	104	0.014
regulation of cellular protein metabolic process	GO:0032268	243	0.014
spindle organization	GO:0007051	253	0.014
regulation of hydrolase activity	GO:0051336	97	0.014
eye morphogenesis	GO:0048592	260	0.014
cuticle development	GO:0042335	86	0.014
regulation of ras protein signal transduction	GO:0046578	93	0.014
positive regulation of signal transduction	GO:0009967	223	0.013
negative regulation of developmental process	GO:0051093	201	0.013
hematopoietic or lymphoid organ development	GO:0048534	57	0.013
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.013
tissue migration	GO:0090130	155	0.013
detection of abiotic stimulus	GO:0009582	66	0.013
embryonic development via the syncytial blastoderm	GO:0001700	148	0.013
purine nucleotide metabolic process	GO:0006163	146	0.013
heart contraction	GO:0060047	26	0.013
g protein coupled receptor signaling pathway	GO:0007186	136	0.013
stem cell division	GO:0017145	69	0.013
cell fate determination	GO:0001709	91	0.013
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.013
regulation of catalytic activity	GO:0050790	185	0.013
cellular amine metabolic process	GO:0044106	12	0.013
positive regulation of cellular catabolic process	GO:0031331	95	0.013
cellular response to ethanol	GO:0071361	4	0.013
choline metabolic process	GO:0019695	1	0.013
regulation of epidermal cell differentiation	GO:0045604	3	0.013
intracellular transport	GO:0046907	228	0.012
regulation of cellular amino acid metabolic process	GO:0006521	0	0.012
negative regulation of cell death	GO:0060548	81	0.012
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.012
chromosome segregation	GO:0007059	157	0.012
neural precursor cell proliferation	GO:0061351	75	0.012
organic hydroxy compound biosynthetic process	GO:1901617	21	0.012
negative regulation of rna metabolic process	GO:0051253	251	0.012
positive regulation of rna biosynthetic process	GO:1902680	266	0.012
positive regulation of molecular function	GO:0044093	136	0.012
regulation of embryonic development	GO:0045995	68	0.012
purine containing compound metabolic process	GO:0072521	155	0.012
cell maturation	GO:0048469	144	0.012
connective tissue development	GO:0061448	3	0.012
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.012
positive regulation of protein metabolic process	GO:0051247	128	0.012
regulation of phosphorylation	GO:0042325	147	0.012
kidney morphogenesis	GO:0060993	3	0.012
stem cell maintenance	GO:0019827	67	0.012
regulation of membrane potential	GO:0042391	35	0.012
photoreceptor cell differentiation	GO:0046530	170	0.012
negative regulation of growth	GO:0045926	84	0.012
female meiosis chromosome segregation	GO:0016321	33	0.012
hormone catabolic process	GO:0042447	3	0.012
endomembrane system organization	GO:0010256	119	0.012
kidney epithelium development	GO:0072073	3	0.012
regulation of purine nucleotide metabolic process	GO:1900542	62	0.012
ethanolamine containing compound metabolic process	GO:0042439	4	0.012
cell cycle phase transition	GO:0044770	140	0.012
secretion	GO:0046903	109	0.012	Human Mouse Rat
acetylcholine catabolic process	GO:0006581	1	0.011
dna replication	GO:0006260	48	0.011
cell death	GO:0008219	279	0.011	Mouse
regulation of cytoskeleton organization	GO:0051493	89	0.011
adult behavior	GO:0030534	137	0.011
mapk cascade	GO:0000165	107	0.011
pyruvate metabolic process	GO:0006090	7	0.011	Yeast
regulation of neuron differentiation	GO:0045664	103	0.011
anterior posterior pattern specification	GO:0009952	136	0.011
nephron tubule development	GO:0072080	3	0.011
regulation of glial cell differentiation	GO:0045685	1	0.011
purine ribonucleotide catabolic process	GO:0009154	109	0.011
response to glucose	GO:0009749	2	0.011	Human
developmental maturation	GO:0021700	172	0.011
regulation of meiosis	GO:0040020	3	0.011
nucleotide metabolic process	GO:0009117	161	0.011	Mouse
response to biotic stimulus	GO:0009607	294	0.011
regulation of cell junction assembly	GO:1901888	2	0.011
nucleotide catabolic process	GO:0009166	109	0.011
protein phosphorylation	GO:0006468	169	0.011
cell aging	GO:0007569	2	0.011
regulation of protein complex disassembly	GO:0043244	29	0.011
long term memory	GO:0007616	62	0.011
synapse organization	GO:0050808	196	0.011
proteolysis	GO:0006508	192	0.011
cell fate commitment involved in pattern specification	GO:0060581	31	0.011
cell growth	GO:0016049	108	0.011
respiratory system development	GO:0060541	213	0.011
tricarboxylic acid metabolic process	GO:0072350	1	0.011
stem cell differentiation	GO:0048863	117	0.010
regulation of response to dna damage stimulus	GO:2001020	23	0.010
cellular homeostasis	GO:0019725	80	0.010	Mouse
glial cell proliferation	GO:0014009	13	0.010
positive regulation of intracellular signal transduction	GO:1902533	116	0.010
regulation of microtubule polymerization or depolymerization	GO:0031110	27	0.010
regulation of gene silencing	GO:0060968	63	0.010
response to nutrient levels	GO:0031667	114	0.010
compound eye development	GO:0048749	307	0.010
oocyte axis specification	GO:0007309	108	0.010
immune system development	GO:0002520	57	0.010
neuronal stem cell maintenance	GO:0097150	4	0.010
maintenance of imaginal disc derived wing hair orientation	GO:0035321	3	0.010
regulation of catabolic process	GO:0009894	170	0.010
positive regulation of cell differentiation	GO:0045597	64	0.010
organelle assembly	GO:0070925	198	0.010

Hex-A disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.035
glucose metabolism disease	DOID:4194	0.018	Human
acquired metabolic disease	DOID:0060158	0.018	Human
disease of metabolism	DOID:0014667	0.018	Human
carbohydrate metabolism disease	DOID:0050013	0.018	Human
nervous system disease	DOID:863	0.016
musculoskeletal system disease	DOID:17	0.016

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