Drosophila melanogaster

121 known processes

SPE (Dmel_CG16705)

Spatzle-Processing Enzyme

(Aliases: proPO-AE,Sp4,SP4,Dmel\CG16705,CG16705,CT37173,c-SP4,spe)

SPE biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
antifungal humoral responseGO:0019732120.998
humoral immune responseGO:00069591170.996
immune responseGO:00069552460.993
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteriaGO:000281630.989
immune system processGO:00023763470.980
peptide metabolic processGO:0006518800.970
response to fungusGO:0009620500.964
regulation of humoral immune responseGO:0002920510.953
antimicrobial peptide productionGO:0002775460.951
activation of innate immune responseGO:000221840.951
antimicrobial humoral responseGO:0019730990.943
antibacterial humoral responseGO:0019731440.942
defense response to other organismGO:00985422250.940
pattern recognition receptor signaling pathwayGO:000222120.921
defense response to fungusGO:0050832480.904
defense response to gram positive bacteriumGO:0050830410.879
phenol containing compound metabolic processGO:0018958570.862
Fly
defense response to bacteriumGO:00427421780.858
innate immune response activating signal transductionGO:000275820.844
regulation of antimicrobial humoral responseGO:0002759500.828
melanization defense responseGO:0035006450.808
Fly
immune response activating signal transductionGO:000275720.799
response to bacteriumGO:00096171980.797
response to biotic stimulusGO:00096072940.793
positive regulation of antibacterial peptide productionGO:0002803200.785
defense responseGO:00069523000.782
positive regulation of antimicrobial humoral responseGO:0002760280.780
regulation of immune responseGO:00507761180.780
regulation of cellular amide metabolic processGO:0034248390.754
positive regulation of biosynthetic process of antibacterial peptides active against gram negative bacteriaGO:0006964120.737
regulation of immune effector processGO:0002697520.720
regulation of production of molecular mediator of immune responseGO:0002700440.695
positive regulation of melanization defense responseGO:003500810.688
Fly
positive regulation of response to biotic stimulusGO:0002833310.683
biosynthetic process of antibacterial peptides active against gram positive bacteriaGO:000281530.669
cellular amide metabolic processGO:0043603800.665
production of molecular mediator of immune responseGO:0002440460.663
positive regulation of antimicrobial peptide biosynthetic processGO:0002807260.638
regulation of multi organism processGO:00439001310.633
response to other organismGO:00517072930.629
positive regulation of humoral immune responseGO:0002922280.624
glycosaminoglycan metabolic processGO:0030203110.618
response to external biotic stimulusGO:00432072930.601
regulation of response to biotic stimulusGO:0002831630.595
negative regulation of peptidoglycan recognition protein signaling pathwayGO:006106030.584
innate immune responseGO:00450871440.582
toll signaling pathwayGO:0008063250.561
organic hydroxy compound metabolic processGO:1901615830.550
Fly
regulation of defense responseGO:00313471020.541
positive regulation of response to external stimulusGO:0032103440.539
melanin metabolic processGO:0006582470.523
Fly
regulation of immune system processGO:00026821760.512
positive regulation of immune responseGO:0050778630.505
positive regulation of biosynthetic process of antibacterial peptides active against gram positive bacteriaGO:000696530.493
positive regulation of defense responseGO:0031349590.490
regulation of response to stressGO:00801342000.480
peptidoglycan metabolic processGO:000027030.474
regulation of peptidoglycan recognition protein signaling pathwayGO:006105840.470
positive regulation of cellular amide metabolic processGO:0034250260.458
regulation of antimicrobial peptide productionGO:0002784440.456
regulation of innate immune responseGO:0045088710.415
Fly
antibacterial peptide productionGO:0002778220.412
positive regulation of antimicrobial peptide productionGO:0002225280.408
dorsal ventral axis specificationGO:0009950660.382
Fly
immune response regulating signaling pathwayGO:000276420.378
organonitrogen compound metabolic processGO:19015643180.375
regulation of secondary metabolic processGO:004345570.345
Fly
negative regulation of defense response to bacteriumGO:190042570.319
positive regulation of production of molecular mediator of immune responseGO:0002702280.312
positive regulation of multi organism processGO:0043902400.310
positive regulation of antibacterial peptide biosynthetic processGO:0006963200.307
regulation of antimicrobial peptide biosynthetic processGO:0002805380.306
antibacterial peptide biosynthetic processGO:0002780220.294
antimicrobial peptide biosynthetic processGO:0002777380.285
axis specificationGO:00097981670.285
Fly
regulation of response to external stimulusGO:00321011150.277
regulation of melanization defense responseGO:003500760.276
Fly
defense response to gram negative bacteriumGO:0050829940.272
peptidoglycan catabolic processGO:000925330.269
regionalizationGO:00030024160.238
Fly
peptide biosynthetic processGO:0043043420.234
positive regulation of nitrogen compound metabolic processGO:00511733540.229
positive regulation of immune effector processGO:0002699280.224
positive regulation of immune system processGO:0002684680.224
glycosaminoglycan catabolic processGO:000602730.221
secondary metabolic processGO:0019748750.215
Fly
regulation of toll signaling pathwayGO:0008592170.212
defense response to virusGO:0051607230.191
response to peptidoglycanGO:003249420.189
positive regulation of response to stimulusGO:00485843230.187
immune effector processGO:0002252980.185
regulation of antibacterial peptide productionGO:0002786220.179
positive regulation of defense response to bacteriumGO:1900426230.174
protein maturationGO:0051604710.174
dorsal ventral pattern formationGO:00099531330.170
Fly
biosynthetic process of antibacterial peptides active against gram negative bacteriaGO:0002812140.169
hemolymph coagulationGO:0042381100.165
Fly
positive regulation of antifungal peptide biosynthetic processGO:000696750.162
endocytosisGO:00068973100.159
Fly
positive regulation of innate immune responseGO:0045089380.152
Fly
positive regulation of biosynthetic processGO:00098913160.148
positive regulation of cellular biosynthetic processGO:00313283160.146
vesicle mediated transportGO:00161923810.146
Fly
negative regulation of peptide hormone processingGO:006057010.137
organonitrogen compound biosynthetic processGO:19015661170.136
activation of immune responseGO:000225350.134
negative regulation of response to external stimulusGO:0032102220.118
phagocytosisGO:00069092150.110
Fly
amide biosynthetic processGO:0043604420.104
positive regulation of signalingGO:00230562430.102
response to nitrogen compoundGO:1901698900.100
wound healingGO:0042060750.099
Fly
negative regulation of cell communicationGO:00106482230.090
detection of stimulusGO:00516061560.088
organic substance catabolic processGO:19015753080.085
carbohydrate derivative metabolic processGO:19011352170.084
positive regulation of cell communicationGO:00106472500.084
negative regulation of defense responseGO:0031348350.083
mucosal immune responseGO:0002385100.073
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteriaGO:0002813140.071
regulation of defense response to bacteriumGO:1900424300.070
melanotic encapsulation of foreign targetGO:0035011300.069
positive regulation of antifungal peptide productionGO:000280460.061
positive regulation of signal transductionGO:00099672230.060
pigment metabolic process involved in pigmentationGO:0043474330.055
response to virusGO:0009615280.053
negative regulation of gene expressionGO:00106293870.051
negative regulation of cellular metabolic processGO:00313243820.050
regulation of defense response to fungusGO:190015060.049
response to molecule of bacterial originGO:000223770.049
agingGO:00075681430.049
cell adhesionGO:00071551360.047
imaginal disc derived appendage morphogenesisGO:00351143950.047
jnk cascadeGO:0007254500.045
negative regulation of signal transductionGO:00099682060.044
response to organophosphorusGO:004668320.044
regulation of antibacterial peptide biosynthetic processGO:0002808220.044
regulation of antifungal peptide productionGO:000278860.043
peptidoglycan recognition protein signaling pathwayGO:0061057160.042
cellular response to lipidGO:0071396200.041
response to nutrient levelsGO:00316671140.040
hormone metabolic processGO:0042445330.040
appendage developmentGO:00487364010.040
negative regulation of nitrogen compound metabolic processGO:00511722650.040
response to organic substanceGO:00100332840.039
carboxylic acid metabolic processGO:0019752920.039
regulation of antifungal peptide biosynthetic processGO:000281050.039
protein processingGO:0016485680.037
lipopolysaccharide mediated signaling pathwayGO:003166310.036
organ or tissue specific immune responseGO:0002251100.036
apical junction assemblyGO:0043297320.035
positive regulation of hemocyte proliferationGO:003520840.035
organic acid metabolic processGO:00060821030.034
cellular response to molecule of bacterial originGO:007121930.034
homeostatic processGO:00425921990.034
cellular response to organic substanceGO:00713101320.033
blastoderm segmentationGO:00073501590.033
regulation of molecular functionGO:00650092170.033
response to endogenous stimulusGO:00097191190.033
retina development in camera type eyeGO:006004140.032
regulation of response to woundingGO:1903034190.032
negative regulation of multi organism processGO:0043901290.032
antifungal peptide biosynthetic processGO:000278350.032
negative regulation of signalingGO:00230572190.031
antifungal peptide productionGO:000278170.031
single organism behaviorGO:00447083910.030
biological adhesionGO:00226101380.030
regulation of transcription from rna polymerase ii promoterGO:00063573780.030
negative regulation of response to stimulusGO:00485852580.029
pigment metabolic processGO:0042440840.029
Fly
proteolysisGO:00065081920.029
Fly
neurological system processGO:00508773580.028
cell junction organizationGO:0034330570.028
rhythmic processGO:00485111060.027
wing disc morphogenesisGO:00074723440.026
mapk cascadeGO:00001651070.026
regulation of phosphorus metabolic processGO:00511742100.026
response to molecule of fungal originGO:000223810.026
negative regulation of molecular functionGO:0044092510.026
negative regulation of innate immune responseGO:0045824300.025
embryonic pattern specificationGO:00098801740.025
peptide hormone processingGO:001648620.025
oxoacid metabolic processGO:00434361030.024
regulation of body fluid levelsGO:0050878140.024
Fly
appendage morphogenesisGO:00351073970.024
synaptic transmissionGO:00072682880.023
eye developmentGO:00016543230.023
spermatogenesisGO:00072832000.023
regulation of intracellular signal transductionGO:19025312360.023
wnt signaling pathwayGO:0016055980.023
regulation of endopeptidase activityGO:0052548360.023
segmentationGO:00352822070.023
single organism catabolic processGO:00447122280.022
neuron projection guidanceGO:00974852410.022
regulation of peptidase activityGO:0052547390.022
signal transduction by phosphorylationGO:00230141070.022
response to lipopolysaccharideGO:003249640.022
camera type eye developmentGO:004301040.022
regulation of cellular protein metabolic processGO:00322682430.022
small molecule metabolic processGO:00442813050.022
cellular response to lipopolysaccharideGO:007122230.022
response to abiotic stimulusGO:00096283410.021
gene silencingGO:00164581380.021
macromolecular complex assemblyGO:00650032560.021
positive regulation of gene expressionGO:00106282900.021
spermatid differentiationGO:00485151140.021
stress activated mapk cascadeGO:0051403520.021
intracellular signal transductionGO:00355563000.021
regulation of hydrolase activityGO:0051336970.020
cell deathGO:00082192790.020
regulation of defense response to virus by hostGO:0050691100.020
cellular catabolic processGO:00442483720.020
neurotransmitter catabolic processGO:004213510.020
open tracheal system developmentGO:00074242040.020
imaginal disc derived appendage developmentGO:00487373990.019
negative regulation of immune responseGO:0050777390.019
developmental pigmentationGO:0048066680.019
response to extracellular stimulusGO:00099911160.019
aminoglycan metabolic processGO:0006022180.019
determination of adult lifespanGO:00083401370.019
epithelial cell differentiationGO:00308553220.018
regulation of proteolysisGO:0030162870.018
chemotaxisGO:00069352490.018
cellular response to biotic stimulusGO:007121640.018
sleepGO:0030431490.018
post embryonic appendage morphogenesisGO:00351203850.018
regulation of mapk cascadeGO:0043408920.018
cellular biogenic amine catabolic processGO:004240210.018
oocyte constructionGO:00073081120.018
negative regulation of stress activated protein kinase signaling cascadeGO:0070303200.018
body morphogenesisGO:001017120.018
male mating behaviorGO:0060179700.018
negative regulation of cellular biosynthetic processGO:00313272770.018
cellular modified amino acid metabolic processGO:0006575450.018
dendrite morphogenesisGO:00488131990.018
detection of chemical stimulusGO:0009593930.017
meiotic nuclear divisionGO:00071261510.017
organelle fissionGO:00482853400.017
positive regulation of macromolecule metabolic processGO:00106044050.017
organonitrogen compound catabolic processGO:19015651280.017
regulation of phosphate metabolic processGO:00192202100.017
actin filament bundle assemblyGO:0051017260.017
endomembrane system organizationGO:00102561190.017
negative regulation of cellular protein metabolic processGO:0032269850.016
response to organic cyclic compoundGO:0014070890.016
positive regulation of phosphate metabolic processGO:00459371390.016
spindle organizationGO:00070512530.016
compound eye developmentGO:00487493070.016
cellular response to chemical stimulusGO:00708871990.016
negative regulation of catalytic activityGO:0043086420.016
transcription from rna polymerase ii promoterGO:00063663680.016
multi multicellular organism processGO:00447061230.016
phosphorylationGO:00163102940.016
catabolic processGO:00090564090.016
macromolecule catabolic processGO:00090571610.016
actin filament organizationGO:00070151260.016
actin filament based processGO:00300292200.015
regulation of circadian rhythmGO:0042752490.015
gene silencing by rnaGO:0031047570.015
chemical homeostasisGO:0048878920.015
imaginal disc derived wing morphogenesisGO:00074763370.015
eye pigmentationGO:0048069430.015
extracellular structure organizationGO:0043062460.015
amine catabolic processGO:000931010.015
negative regulation of phosphorylationGO:0042326350.015
chromosome segregationGO:00070591570.015
sperm individualizationGO:0007291480.015
anterior posterior axis specification embryoGO:00085951030.015
protein complex assemblyGO:00064612000.015
multicellular organismal agingGO:00102591400.015
regulation of gene expression epigeneticGO:00400291280.015
extrinsic apoptotic signaling pathwayGO:009719110.014
growthGO:00400073590.014
neural retina developmentGO:000340740.014
axon developmentGO:00615642970.014
regulation of protein metabolic processGO:00512462560.014
neurotransmitter metabolic processGO:004213320.014
response to woundingGO:0009611940.014
Fly
response to organonitrogen compoundGO:0010243750.014
cellular amino acid metabolic processGO:0006520610.014
ameboidal type cell migrationGO:00016671510.014
salivary gland developmentGO:00074311620.014
protein modification processGO:00362114380.014
cellularizationGO:0007349900.014
neuron deathGO:0070997270.014
developmental maturationGO:00217001720.014
neuron recognitionGO:00080381010.014
negative regulation of protein metabolic processGO:0051248850.013
negative regulation of developmental processGO:00510932010.013
anterior posterior pattern specificationGO:00099521360.013
regulation of cell adhesionGO:0030155270.013
segment polarity determinationGO:0007367250.013
mitotic sister chromatid segregationGO:0000070870.013
regulation of catalytic activityGO:00507901850.013
regulation of i kappab kinase nf kappab signalingGO:004312220.013
developmental programmed cell deathGO:00106231380.013
stress activated protein kinase signaling cascadeGO:0031098550.013
negative regulation of intracellular signal transductionGO:1902532570.013
regulation of anatomical structure morphogenesisGO:00226032420.013
posttranscriptional gene silencingGO:0016441460.013
axon guidanceGO:00074112330.013
nucleobase containing small molecule metabolic processGO:00550861740.013
rhythmic behaviorGO:0007622760.013
gland morphogenesisGO:00226121450.013
zymogen activationGO:0031638200.013
positive regulation of intracellular signal transductionGO:19025331160.012
organic cyclic compound catabolic processGO:19013611680.012
septate junction assemblyGO:0019991260.012
hormone catabolic processGO:004244730.012
organophosphate metabolic processGO:00196371950.012
cell proliferationGO:00082832990.012
protein localizationGO:00081042840.012
negative regulation of mapk cascadeGO:0043409230.012
sensory organ morphogenesisGO:00905962600.012
positive regulation of defense response to virus by hostGO:0002230100.012
developmental growthGO:00485892800.012
regulation of cellular response to stressGO:0080135890.012
multi organism behaviorGO:00517051750.012
cell cell junction organizationGO:0045216550.012
negative regulation of proteolysisGO:0045861310.012
columnar cuboidal epithelial cell differentiationGO:00020652560.012
negative regulation of rna metabolic processGO:00512532510.012
heterocycle catabolic processGO:00467001660.012
membrane depolarizationGO:005189940.012
retinal cell programmed cell deathGO:0046666250.012
negative regulation of rna biosynthetic processGO:19026792400.012
pyridine containing compound metabolic processGO:007252430.012
ovarian follicle cell developmentGO:00307072480.011
cell cell signaling involved in cell fate commitmentGO:00451682100.011
regulation of organ morphogenesisGO:2000027780.011
positive regulation of cell motilityGO:200014730.011
regulation of symbiosis encompassing mutualism through parasitismGO:0043903150.011
nuclear divisionGO:00002803320.011
digestive tract developmentGO:00485651490.011
autophagic cell deathGO:0048102830.011
central nervous system developmentGO:00074172010.011
positive regulation of molecular functionGO:00440931360.011
columnar cuboidal epithelial cell developmentGO:00020662490.011
response to alcoholGO:0097305950.011
response to oxygen containing compoundGO:19017002000.011
cellular ketone metabolic processGO:0042180240.011
renal tubule developmentGO:0061326640.011
anterior posterior axis specificationGO:00099481090.011
germarium derived egg chamber formationGO:00072931010.011
negative regulation of macromolecule biosynthetic processGO:00105582700.011
regulation of gene silencingGO:0060968630.011
detection of abiotic stimulusGO:0009582660.011
chromatin silencingGO:0006342760.010
negative regulation of nucleobase containing compound metabolic processGO:00459342610.010
mitotic nuclear divisionGO:00070672130.010
negative regulation of cell deathGO:0060548810.010
positive regulation of i kappab kinase nf kappab signalingGO:004312310.010
dendrite developmentGO:00163582040.010
peripheral nervous system developmentGO:0007422520.010
negative regulation of cellular amide metabolic processGO:003424930.010
oxidation reduction processGO:00551141230.010
courtship behaviorGO:0007619680.010
establishment of localization in cellGO:00516494020.010

SPE disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.029
disease of metabolismDOID:001466700.016
nervous system diseaseDOID:86300.014
disease of cellular proliferationDOID:1456600.014
cancerDOID:16200.014
organ system cancerDOID:005068600.011