Drosophila melanogaster

49 known processes

PGRP-LE (Dmel_CG8995)

Peptidoglycan recognition protein LE

(Aliases: PGRP,anon-WO0153538.66,Dmel\CG8995,CG8995)

PGRP-LE biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
immune responseGO:00069552460.528
chitin based cuticle sclerotizationGO:0007593190.402
response to other organismGO:00517072930.257
regulation of chitin based cuticle tanningGO:0007564140.225
adult chitin containing cuticle pigmentationGO:0048085160.210
muscle structure developmentGO:00610612240.190
regulation of endopeptidase activityGO:0052548360.173
defense responseGO:00069523000.165
regulation of antibacterial peptide biosynthetic processGO:0002808220.150
Fly
catabolic processGO:00090564090.147
Fly
developmental pigmentationGO:0048066680.133
response to inorganic substanceGO:0010035440.130
regulation of cuticle pigmentationGO:0048079160.129
response to external biotic stimulusGO:00432072930.128
humoral immune responseGO:00069591170.122
Fly
antibacterial humoral responseGO:0019731440.113
Fly
regulation of response to stressGO:00801342000.110
regulation of immune responseGO:00507761180.109
regulation of multi organism processGO:00439001310.104
Fly
neurological system processGO:00508773580.103
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280230.102
cellular response to dna damage stimulusGO:00069742230.102
response to oxygen containing compoundGO:19017002000.100
Fly
response to biotic stimulusGO:00096072940.099
peptide metabolic processGO:0006518800.096
Fly
cuticle pigmentationGO:0048067220.094
innate immune responseGO:00450871440.093
response to bacteriumGO:00096171980.093
regulation of adult chitin containing cuticle pigmentationGO:0048082130.092
metal ion transportGO:0030001740.091
positive regulation of macromolecule metabolic processGO:00106044050.091
molting cycle chitin based cuticleGO:0007591560.090
regulation of cellular localizationGO:00603411360.090
regulation of defense response to virus by hostGO:0050691100.090
transmembrane transportGO:00550851390.088
positive regulation of response to stimulusGO:00485843230.088
spermatogenesisGO:00072832000.085
organic substance catabolic processGO:19015753080.084
Fly
regulation of transcription from rna polymerase ii promoterGO:00063573780.083
regulation of response to external stimulusGO:00321011150.083
Fly
vesicle mediated transportGO:00161923810.082
response to abiotic stimulusGO:00096283410.081
regulation of transportGO:00510491810.080
response to organonitrogen compoundGO:0010243750.080
Fly
defense response to bacteriumGO:00427421780.080
defense response to gram negative bacteriumGO:0050829940.079
Fly
cell proliferationGO:00082832990.075
positive regulation of signal transductionGO:00099672230.075
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteriaGO:000281630.075
Fly
negative regulation of gene expressionGO:00106293870.074
positive regulation of cellular biosynthetic processGO:00313283160.073
Fly
positive regulation of biosynthetic processGO:00098913160.072
Fly
developmental maturationGO:00217001720.071
oocyte axis specificationGO:00073091080.070
intracellular signal transductionGO:00355563000.070
Fly
positive regulation of gene expressionGO:00106282900.069
cellular component assembly involved in morphogenesisGO:00109271510.068
molting cycle processGO:0022404290.067
chromosome organizationGO:00512763600.067
regionalizationGO:00030024160.066
ion transportGO:00068111450.065
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.064
organonitrogen compound biosynthetic processGO:19015661170.064
Fly
positive regulation of transcription dna templatedGO:00458932660.063
endocytosisGO:00068973100.063
pigmentationGO:0043473750.061
response to starvationGO:0042594970.060
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281250.060
regulation of protein metabolic processGO:00512462560.059
programmed cell deathGO:00125012570.056
positive regulation of cell communicationGO:00106472500.055
positive regulation of nitrogen compound metabolic processGO:00511733540.055
Fly
positive regulation of production of molecular mediator of immune responseGO:0002702280.054
Fly
single organism biosynthetic processGO:00447112060.054
protein localization to nucleusGO:0034504550.054
intracellular transportGO:00469072280.054
regulation of cysteine type endopeptidase activityGO:2000116270.054
cation transportGO:00068121100.054
dna integrity checkpointGO:0031570810.053
positive regulation of rna metabolic processGO:00512542710.053
regulation of immune effector processGO:0002697520.053
Fly
wing disc morphogenesisGO:00074723440.053
regulation of proteolysisGO:0030162870.053
cation transmembrane transportGO:0098655880.052
negative regulation of cellular metabolic processGO:00313243820.051
Fly
spermatid differentiationGO:00485151140.051
cell deathGO:00082192790.051
phagocytosisGO:00069092150.049
regulation of humoral immune responseGO:0002920510.049
Fly
positive regulation of defense response to virus by hostGO:0002230100.048
nuclear importGO:0051170510.048
regulation of catalytic activityGO:00507901850.048
cell divisionGO:00513012480.047
apoptotic processGO:00069151590.047
response to organic substanceGO:00100332840.047
Fly
regulation of localizationGO:00328792750.047
establishment of localization in cellGO:00516494020.047
positive regulation of signalingGO:00230562430.046
small molecule metabolic processGO:00442813050.046
male gamete generationGO:00482322010.045
regulation of peptidase activityGO:0052547390.045
regulation of innate immune responseGO:0045088710.045
deathGO:00162652840.043
proteolysisGO:00065081920.043
response to extracellular stimulusGO:00099911160.042
regulation of intracellular protein transportGO:0033157460.042
nuclear divisionGO:00002803320.042
antimicrobial humoral responseGO:0019730990.042
Fly
single organism nuclear importGO:1902593510.042
regulation of response to biotic stimulusGO:0002831630.041
Fly
regulation of programmed cell deathGO:00430671520.041
positive regulation of programmed cell deathGO:0043068620.041
regulation of multicellular organismal developmentGO:20000264140.041
single organism behaviorGO:00447083910.040
regulation of cytoplasmic transportGO:1903649470.040
regulation of cellular protein metabolic processGO:00322682430.040
immune system processGO:00023763470.040
molting cycleGO:0042303560.039
response to nutrient levelsGO:00316671140.039
regulation of production of molecular mediator of immune responseGO:0002700440.039
Fly
oocyte constructionGO:00073081120.038
regulation of apoptotic processGO:00429811300.038
positive regulation of nucleic acid templated transcriptionGO:19035082660.038
translationGO:0006412690.037
sensory organ morphogenesisGO:00905962600.037
protein localizationGO:00081042840.037
regulation of cell cycleGO:00517262910.037
regulation of immune system processGO:00026821760.036
open tracheal system developmentGO:00074242040.036
regulation of defense response to bacteriumGO:1900424300.036
Fly
regulation of protein import into nucleusGO:0042306280.036
regulation of i kappab kinase nf kappab signalingGO:004312220.036
post embryonic appendage morphogenesisGO:00351203850.036
positive regulation of phosphate metabolic processGO:00459371390.035
positive regulation of endopeptidase activityGO:0010950260.035
imaginal disc derived appendage developmentGO:00487373990.035
cell migrationGO:00164772380.035
regulation of antimicrobial humoral responseGO:0002759500.035
Fly
positive regulation of peptidase activityGO:0010952290.034
spermatid developmentGO:0007286980.034
regulation of cell deathGO:00109411730.034
organelle fissionGO:00482853400.034
muscle cell differentiationGO:00426921030.033
ion transmembrane transportGO:00342201220.033
negative regulation of cell cycleGO:00457861160.033
regulation of cell cycle processGO:00105641810.033
positive regulation of macromolecule biosynthetic processGO:00105572830.033
positive regulation of protein metabolic processGO:00512471280.032
cell cycle checkpointGO:0000075950.032
regulation of defense response to virusGO:0050688140.032
regulation of cellular response to stressGO:0080135890.032
Fly
single organism cellular localizationGO:19025801800.032
negative regulation of cellular protein metabolic processGO:0032269850.032
negative regulation of response to stimulusGO:00485852580.031
Fly
protein processingGO:0016485680.031
phosphorylationGO:00163102940.031
Fly
appendage morphogenesisGO:00351073970.031
response to hydrogen peroxideGO:0042542110.031
positive regulation of protein import into nucleusGO:0042307210.031
defense response to other organismGO:00985422250.031
dna metabolic processGO:00062592270.031
single organism intracellular transportGO:19025822070.031
appendage developmentGO:00487364010.030
eye morphogenesisGO:00485922600.030
cytoplasmic transportGO:00164821300.030
negative regulation of protein metabolic processGO:0051248850.030
protein modification processGO:00362114380.030
positive regulation of response to external stimulusGO:0032103440.030
Fly
transcription from rna polymerase ii promoterGO:00063663680.030
cell maturationGO:00484691440.030
regulation of phosphorus metabolic processGO:00511742100.029
Fly
positive regulation of humoral immune responseGO:0002922280.029
Fly
response to temperature stimulusGO:00092661060.029
regulation of nucleocytoplasmic transportGO:0046822350.029
response to metal ionGO:0010038230.029
regulation of system processGO:0044057360.029
antimicrobial peptide biosynthetic processGO:0002777380.029
Fly
muscle organ developmentGO:00075171270.029
negative regulation of developmental processGO:00510932010.029
organonitrogen compound metabolic processGO:19015643180.029
Fly
response to oxygen radicalGO:000030530.029
organic substance transportGO:00717022570.029
Fly
forebrain developmentGO:003090020.028
actin cytoskeleton organizationGO:00300362060.028
positive regulation of antibacterial peptide productionGO:0002803200.027
Fly
cellular response to chemical stimulusGO:00708871990.027
Fly
eggshell formationGO:00307031050.027
imaginal disc derived wing morphogenesisGO:00074763370.027
imaginal disc derived appendage morphogenesisGO:00351143950.027
positive regulation of nucleocytoplasmic transportGO:0046824240.027
chromatin remodelingGO:0006338720.026
positive regulation of protein transportGO:0051222370.026
regulation of developmental pigmentationGO:0048070240.026
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919160.026
positive regulation of antimicrobial humoral responseGO:0002760280.026
Fly
positive regulation of cysteine type endopeptidase activityGO:2001056240.026
response to glucoseGO:000974920.025
regulation of intracellular transportGO:0032386640.024
negative regulation of cellular biosynthetic processGO:00313272770.024
negative regulation of macromolecule biosynthetic processGO:00105582700.024
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.024
cellular catabolic processGO:00442483720.024
striated muscle cell differentiationGO:0051146900.024
nitrogen compound transportGO:0071705850.024
Fly
digestive tract morphogenesisGO:00485461270.024
positive regulation of cell deathGO:0010942690.023
genital disc developmentGO:0035215440.023
intracellular mrna localization involved in anterior posterior axis specificationGO:0060811530.023
necrotic cell deathGO:007026510.023
connective tissue developmentGO:006144830.023
response to organophosphorusGO:004668320.023
response to radiationGO:00093141550.023
eye developmentGO:00016543230.023
positive regulation of apoptotic processGO:0043065470.023
cuticle developmentGO:0042335860.022
positive regulation of immune responseGO:0050778630.022
regulation of anatomical structure sizeGO:00900661630.022
myotube cell developmentGO:001490430.022
antimicrobial peptide productionGO:0002775460.022
Fly
regulation of antibacterial peptide productionGO:0002786220.022
Fly
immune effector processGO:0002252980.022
Fly
central nervous system developmentGO:00074172010.022
positive regulation of protein localization to nucleusGO:1900182210.022
negative regulation of biosynthetic processGO:00098902770.021
organophosphate catabolic processGO:00464341120.021
regulation of protein transportGO:0051223570.021
telencephalon developmentGO:002153720.021
chromatin organizationGO:00063252070.021
actin filament based processGO:00300292200.021
respiratory system developmentGO:00605412130.021
negative regulation of mitotic cell cycleGO:00459301090.021
regulation of stress activated protein kinase signaling cascadeGO:0070302420.021
Fly
positive regulation of response to biotic stimulusGO:0002833310.021
Fly
protein targeting to nucleusGO:0044744510.021
response to monosaccharideGO:003428440.021
protein importGO:0017038550.021
negative regulation of cell differentiationGO:00455961430.021
organonitrogen compound catabolic processGO:19015651280.021
Fly
single organism catabolic processGO:00447122280.021
positive regulation of antimicrobial peptide productionGO:0002225280.021
Fly
secondary metabolic processGO:0019748750.021
Fly
response to light stimulusGO:00094161240.020
muscle cell developmentGO:0055001500.020
positive regulation of intracellular transportGO:0032388420.020
regulation of defense responseGO:00313471020.020
regulation of cellular component sizeGO:0032535980.020
positive regulation of multi organism processGO:0043902400.020
Fly
cellular response to extracellular stimulusGO:0031668640.020
positive regulation of canonical wnt signaling pathwayGO:009026370.020
positive regulation of nucleobase containing compound metabolic processGO:00459353320.020
epithelial cell differentiationGO:00308553220.020
lipid biosynthetic processGO:0008610460.020
carboxylic acid metabolic processGO:0019752920.020
stem cell differentiationGO:00488631170.020
mitotic spindle organizationGO:00070522200.019
protein catabolic processGO:00301631010.019
oocyte developmentGO:00485991240.019
regulation of antimicrobial peptide productionGO:0002784440.019
Fly
segmentationGO:00352822070.019
mitotic nuclear divisionGO:00070672130.019
regulation of protein localizationGO:0032880760.019
positive regulation of intracellular signal transductionGO:19025331160.019
membrane organizationGO:00610241120.019
compound eye developmentGO:00487493070.019
regulation of protein localization to nucleusGO:1900180290.019
organophosphate metabolic processGO:00196371950.019
germ line stem cell maintenanceGO:0030718500.019
regulation of establishment of protein localizationGO:0070201610.019
embryonic morphogenesisGO:00485982060.019
cellular response to oxidative stressGO:0034599280.018
cellular amino acid metabolic processGO:0006520610.018
cellular protein modification processGO:00064644380.018
g2 dna damage checkpointGO:0031572690.018
columnar cuboidal epithelial cell differentiationGO:00020652560.018
extrinsic apoptotic signaling pathwayGO:009719110.018
cellular response to molecule of bacterial originGO:007121930.018
Fly
synaptic transmissionGO:00072682880.018
protein transportGO:00150311550.018
negative regulation of nitrogen compound metabolic processGO:00511722650.018
regulation of phosphate metabolic processGO:00192202100.018
Fly
striated muscle cell developmentGO:0055002500.018
protein maturationGO:0051604710.018
positive regulation of phosphorus metabolic processGO:00105621390.018
response to nitrogen compoundGO:1901698900.018
Fly
protein import into nucleusGO:0006606510.018
eggshell chorion assemblyGO:0007306660.017
protein modification by small protein conjugation or removalGO:00706471060.017
response to copper ionGO:004668840.017
response to oxidative stressGO:0006979860.017
blastoderm segmentationGO:00073501590.017
cellular response to oxygen containing compoundGO:1901701790.017
Fly
stress activated protein kinase signaling cascadeGO:0031098550.017
Fly
negative regulation of apoptotic processGO:0043066630.017
positive regulation of intracellular protein transportGO:0090316300.017
dendrite morphogenesisGO:00488131990.017
negative regulation of transcription dna templatedGO:00458922370.017
maternal determination of anterior posterior axis embryoGO:0008358740.017
head developmentGO:00603221350.017
intracellular protein transportGO:00068861040.017
regulation of autophagyGO:0010506620.017
columnar cuboidal epithelial cell developmentGO:00020662490.017
response to lipopolysaccharideGO:003249640.016
Fly
amide biosynthetic processGO:0043604420.016
Fly
positive regulation of cellular protein metabolic processGO:00322701180.016
dorsal appendage formationGO:0046843470.016
nucleoside triphosphate catabolic processGO:00091431080.016
nuclear transportGO:0051169720.016
response to lipidGO:0033993380.016
Fly
compound eye morphogenesisGO:00017452490.016
protein complex assemblyGO:00064612000.016
cognitionGO:00508901410.016
peptide biosynthetic processGO:0043043420.016
Fly
response to hexoseGO:000974630.016
peptidoglycan recognition protein signaling pathwayGO:0061057160.016
organic acid metabolic processGO:00060821030.016
wound healingGO:0042060750.016
homeostatic processGO:00425921990.015
protein phosphorylationGO:00064681690.015
regulation of hydrolase activityGO:0051336970.015
chromatin modificationGO:00165681470.015
heterocycle catabolic processGO:00467001660.015
establishment or maintenance of cytoskeleton polarityGO:0030952440.015
negative regulation of cell deathGO:0060548810.015
stem cell maintenanceGO:0019827670.015
regulation of mapk cascadeGO:0043408920.015
Fly
lateral inhibitionGO:00463312060.015
digestive tract developmentGO:00485651490.015
cell type specific apoptotic processGO:0097285380.015
regulation of cellular component biogenesisGO:00440872010.015
response to peptideGO:1901652290.015
gene silencingGO:00164581380.015
negative regulation of signalingGO:00230572190.014
Fly
regulation of antimicrobial peptide biosynthetic processGO:0002805380.014
Fly
carbohydrate metabolic processGO:0005975820.014
positive regulation of proteolysisGO:0045862520.014
response to superoxideGO:000030330.014
negative regulation of multicellular organismal processGO:00512411420.014
establishment of protein localizationGO:00451841630.014
spindle organizationGO:00070512530.014
regulation of protein processingGO:0070613320.014
negative regulation of immune system processGO:0002683500.014
Fly
cellular amide metabolic processGO:0043603800.014
Fly
response to organic cyclic compoundGO:0014070890.014
negative regulation of immune responseGO:0050777390.014
Fly
signal transduction in response to dna damageGO:004277030.014
response to reactive oxygen speciesGO:0000302240.014
response to woundingGO:0009611940.014
negative regulation of innate immune responseGO:0045824300.014
Fly
regulation of protein targetingGO:1903533290.014
cell agingGO:000756920.014
organ or tissue specific immune responseGO:0002251100.014
nucleobase containing small molecule metabolic processGO:00550861740.014
embryonic pattern specificationGO:00098801740.014
apoptotic signaling pathwayGO:0097190270.014
positive regulation of rna biosynthetic processGO:19026802660.014
positive regulation of transportGO:0051050920.013
epiboly involved in wound healingGO:009050520.013
lipopolysaccharide mediated signaling pathwayGO:003166310.013
Fly
negative regulation of growthGO:0045926840.013
cellular response to arsenic containing substanceGO:007124360.013
protein modification by small protein conjugationGO:0032446790.013
positive regulation of cell motilityGO:200014730.013
gonad developmentGO:0008406500.013
cellular response to organic substanceGO:00713101320.013
Fly
regulation of mrna splicing via spliceosomeGO:0048024640.013
modification dependent protein catabolic processGO:0019941780.013
antibacterial peptide productionGO:0002778220.013
Fly
regulation of cell differentiationGO:00455953020.013
purine nucleoside metabolic processGO:00422781270.013
endoderm formationGO:000170630.013
establishment or maintenance of cell polarityGO:00071631670.013
nucleocytoplasmic transportGO:0006913720.013
digestive system developmentGO:00551231490.013
purine ribonucleoside catabolic processGO:00461301120.013
negative regulation of nucleobase containing compound metabolic processGO:00459342610.013
regulation of intracellular signal transductionGO:19025312360.013
Fly
response to endogenous stimulusGO:00097191190.013
Fly
cellular response to peptide hormone stimulusGO:0071375280.013
macromolecule catabolic processGO:00090571610.013
Fly
negative regulation of rna metabolic processGO:00512532510.013
cellular response to nutrient levelsGO:0031669620.013
positive regulation of antimicrobial peptide biosynthetic processGO:0002807260.013
Fly
regulation of cell sizeGO:0008361630.013
pole plasm assemblyGO:0007315610.013
glycosyl compound catabolic processGO:19016581120.013
salivary gland cell autophagic cell deathGO:0035071830.013
nucleoside phosphate metabolic processGO:00067531620.013
stress activated mapk cascadeGO:0051403520.013
Fly
negative regulation of programmed cell deathGO:0043069720.013
ovarian follicle cell developmentGO:00307072480.012
organic hydroxy compound metabolic processGO:1901615830.012
Fly
cellular macromolecule localizationGO:00707272200.012
negative regulation of proteolysisGO:0045861310.012
signal transduction by phosphorylationGO:00230141070.012
Fly
female gonad developmentGO:0008585120.012
regulation of vesicle mediated transportGO:0060627590.012
tube morphogenesisGO:00352391910.012
regulation of behaviorGO:0050795750.012
anterior posterior axis specificationGO:00099481090.012
positive regulation of cell migrationGO:003033520.012
dna damage checkpointGO:0000077780.012
photoreceptor cell differentiationGO:00465301700.012
ribonucleoside metabolic processGO:00091191270.012
epithelial cell developmentGO:00020642740.012
collateral sprouting of injured axonGO:004867430.012
cellular homeostasisGO:0019725800.012
protein targetingGO:0006605640.012
inorganic ion transmembrane transportGO:0098660730.012
lipid metabolic processGO:00066291210.012
salivary gland developmentGO:00074311620.012
regulation of synapse structure and activityGO:00508031280.012
pigment metabolic processGO:0042440840.012
Fly
peptidyl amino acid modificationGO:00181931050.012
camera type eye developmentGO:004301040.012
ion homeostasisGO:0050801550.011
hormone catabolic processGO:004244730.011
regulation of rna splicingGO:0043484690.011
reactive oxygen species metabolic processGO:0072593220.011
skeletal muscle fiber developmentGO:004874130.011
regulation of translationGO:0006417560.011
mapk cascadeGO:00001651070.011
Fly
atp metabolic processGO:0046034490.011
dna dependent dna replicationGO:0006261170.011
tissue morphogenesisGO:00487292970.011
localization of cellGO:00516742570.011
cellular chemical homeostasisGO:0055082400.011
negative regulation of nucleic acid templated transcriptionGO:19035072400.011
regulation of catabolic processGO:00098941700.011
dendrite developmentGO:00163582040.011
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:007005940.011
pattern recognition receptor signaling pathwayGO:000222120.011
Fly
androgen metabolic processGO:000820910.011
protein ubiquitinationGO:0016567700.011
positive regulation of reactive oxygen species metabolic processGO:200037900.011
transition metal ion transportGO:0000041160.011
establishment of protein localization to organelleGO:0072594620.011
positive regulation of mapk cascadeGO:0043410630.011
regulation of molecular functionGO:00650092170.011
intracellular mrna localization involved in pattern specification processGO:0060810560.011
organelle assemblyGO:00709251980.011
positive regulation of cellular amide metabolic processGO:0034250260.011
Fly
regulation of mitotic cell cycleGO:00073461900.011
reproductive structure developmentGO:0048608740.011
oocyte microtubule cytoskeleton polarizationGO:0008103220.011
i kappab phosphorylationGO:000725230.011
ribonucleoside triphosphate catabolic processGO:00092031080.011
negative regulation of protein processingGO:0010955310.011
cellular ketone metabolic processGO:0042180240.011
negative regulation of rna biosynthetic processGO:19026792400.011
positive regulation of defense responseGO:0031349590.010
morphogenesis of an epitheliumGO:00020092760.010
positive regulation of phosphorylationGO:0042327870.010
purine containing compound metabolic processGO:00725211550.010
chromosome segregationGO:00070591570.010
cell cycle arrestGO:000705040.010
positive regulation of apoptotic signaling pathwayGO:200123540.010
adult behaviorGO:00305341370.010
negative regulation of catalytic activityGO:0043086420.010
single organism carbohydrate metabolic processGO:0044723720.010
regulation of phosphorylationGO:00423251470.010
Fly
cellular lipid metabolic processGO:0044255830.010
protein heterooligomerizationGO:005129140.010
asymmetric cell divisionGO:0008356370.010

PGRP-LE disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.045
disease of cellular proliferationDOID:1456600.019
cancerDOID:16200.019
central nervous system diseaseDOID:33100.010
nervous system diseaseDOID:86300.010