IMP: Integrative Multi-species Prediction

Drosophila melanogaster

49 known processes

PGRP-LE (Dmel_CG8995)

Peptidoglycan recognition protein LE

(Aliases: PGRP,anon-WO0153538.66,Dmel\CG8995,CG8995)

Entrez: 32534
FLYBASE: FBgn0030695
UniProtKB: Q9VXN9
UniProtKB: M9NDY2

Process Predictions
Disease Predictions

PGRP-LE biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
immune response	GO:0006955	246	0.528
chitin based cuticle sclerotization	GO:0007593	19	0.402
response to other organism	GO:0051707	293	0.257
regulation of chitin based cuticle tanning	GO:0007564	14	0.225
adult chitin containing cuticle pigmentation	GO:0048085	16	0.210
muscle structure development	GO:0061061	224	0.190
regulation of endopeptidase activity	GO:0052548	36	0.173
defense response	GO:0006952	300	0.165
regulation of antibacterial peptide biosynthetic process	GO:0002808	22	0.150	Fly
catabolic process	GO:0009056	409	0.147	Fly
developmental pigmentation	GO:0048066	68	0.133
response to inorganic substance	GO:0010035	44	0.130
regulation of cuticle pigmentation	GO:0048079	16	0.129
response to external biotic stimulus	GO:0043207	293	0.128
humoral immune response	GO:0006959	117	0.122	Fly
antibacterial humoral response	GO:0019731	44	0.113	Fly
regulation of response to stress	GO:0080134	200	0.110
regulation of immune response	GO:0050776	118	0.109
regulation of multi organism process	GO:0043900	131	0.104	Fly
neurological system process	GO:0050877	358	0.103
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.102
cellular response to dna damage stimulus	GO:0006974	223	0.102
response to oxygen containing compound	GO:1901700	200	0.100	Fly
response to biotic stimulus	GO:0009607	294	0.099
peptide metabolic process	GO:0006518	80	0.096	Fly
cuticle pigmentation	GO:0048067	22	0.094
innate immune response	GO:0045087	144	0.093
response to bacterium	GO:0009617	198	0.093
regulation of adult chitin containing cuticle pigmentation	GO:0048082	13	0.092
metal ion transport	GO:0030001	74	0.091
positive regulation of macromolecule metabolic process	GO:0010604	405	0.091
molting cycle chitin based cuticle	GO:0007591	56	0.090
regulation of cellular localization	GO:0060341	136	0.090
regulation of defense response to virus by host	GO:0050691	10	0.090
transmembrane transport	GO:0055085	139	0.088
positive regulation of response to stimulus	GO:0048584	323	0.088
spermatogenesis	GO:0007283	200	0.085
organic substance catabolic process	GO:1901575	308	0.084	Fly
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.083
regulation of response to external stimulus	GO:0032101	115	0.083	Fly
vesicle mediated transport	GO:0016192	381	0.082
response to abiotic stimulus	GO:0009628	341	0.081
regulation of transport	GO:0051049	181	0.080
response to organonitrogen compound	GO:0010243	75	0.080	Fly
defense response to bacterium	GO:0042742	178	0.080
defense response to gram negative bacterium	GO:0050829	94	0.079	Fly
cell proliferation	GO:0008283	299	0.075
positive regulation of signal transduction	GO:0009967	223	0.075
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria	GO:0002816	3	0.075	Fly
negative regulation of gene expression	GO:0010629	387	0.074
positive regulation of cellular biosynthetic process	GO:0031328	316	0.073	Fly
positive regulation of biosynthetic process	GO:0009891	316	0.072	Fly
developmental maturation	GO:0021700	172	0.071
oocyte axis specification	GO:0007309	108	0.070
intracellular signal transduction	GO:0035556	300	0.070	Fly
positive regulation of gene expression	GO:0010628	290	0.069
cellular component assembly involved in morphogenesis	GO:0010927	151	0.068
molting cycle process	GO:0022404	29	0.067
chromosome organization	GO:0051276	360	0.067
regionalization	GO:0003002	416	0.066
ion transport	GO:0006811	145	0.065
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.064
organonitrogen compound biosynthetic process	GO:1901566	117	0.064	Fly
positive regulation of transcription dna templated	GO:0045893	266	0.063
endocytosis	GO:0006897	310	0.063
pigmentation	GO:0043473	75	0.061
response to starvation	GO:0042594	97	0.060
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.060
regulation of protein metabolic process	GO:0051246	256	0.059
programmed cell death	GO:0012501	257	0.056
positive regulation of cell communication	GO:0010647	250	0.055
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.055	Fly
positive regulation of production of molecular mediator of immune response	GO:0002702	28	0.054	Fly
single organism biosynthetic process	GO:0044711	206	0.054
protein localization to nucleus	GO:0034504	55	0.054
intracellular transport	GO:0046907	228	0.054
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.054
cation transport	GO:0006812	110	0.054
dna integrity checkpoint	GO:0031570	81	0.053
positive regulation of rna metabolic process	GO:0051254	271	0.053
regulation of immune effector process	GO:0002697	52	0.053	Fly
wing disc morphogenesis	GO:0007472	344	0.053
regulation of proteolysis	GO:0030162	87	0.053
cation transmembrane transport	GO:0098655	88	0.052
negative regulation of cellular metabolic process	GO:0031324	382	0.051	Fly
spermatid differentiation	GO:0048515	114	0.051
cell death	GO:0008219	279	0.051
phagocytosis	GO:0006909	215	0.049
regulation of humoral immune response	GO:0002920	51	0.049	Fly
positive regulation of defense response to virus by host	GO:0002230	10	0.048
nuclear import	GO:0051170	51	0.048
regulation of catalytic activity	GO:0050790	185	0.048
cell division	GO:0051301	248	0.047
apoptotic process	GO:0006915	159	0.047
response to organic substance	GO:0010033	284	0.047	Fly
regulation of localization	GO:0032879	275	0.047
establishment of localization in cell	GO:0051649	402	0.047
positive regulation of signaling	GO:0023056	243	0.046
small molecule metabolic process	GO:0044281	305	0.046
male gamete generation	GO:0048232	201	0.045
regulation of peptidase activity	GO:0052547	39	0.045
regulation of innate immune response	GO:0045088	71	0.045
death	GO:0016265	284	0.043
proteolysis	GO:0006508	192	0.043
response to extracellular stimulus	GO:0009991	116	0.042
regulation of intracellular protein transport	GO:0033157	46	0.042
nuclear division	GO:0000280	332	0.042
antimicrobial humoral response	GO:0019730	99	0.042	Fly
single organism nuclear import	GO:1902593	51	0.042
regulation of response to biotic stimulus	GO:0002831	63	0.041	Fly
regulation of programmed cell death	GO:0043067	152	0.041
positive regulation of programmed cell death	GO:0043068	62	0.041
regulation of multicellular organismal development	GO:2000026	414	0.041
single organism behavior	GO:0044708	391	0.040
regulation of cytoplasmic transport	GO:1903649	47	0.040
regulation of cellular protein metabolic process	GO:0032268	243	0.040
immune system process	GO:0002376	347	0.040
molting cycle	GO:0042303	56	0.039
response to nutrient levels	GO:0031667	114	0.039
regulation of production of molecular mediator of immune response	GO:0002700	44	0.039	Fly
oocyte construction	GO:0007308	112	0.038
regulation of apoptotic process	GO:0042981	130	0.038
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.038
translation	GO:0006412	69	0.037
sensory organ morphogenesis	GO:0090596	260	0.037
protein localization	GO:0008104	284	0.037
regulation of cell cycle	GO:0051726	291	0.037
regulation of immune system process	GO:0002682	176	0.036
open tracheal system development	GO:0007424	204	0.036
regulation of defense response to bacterium	GO:1900424	30	0.036	Fly
regulation of protein import into nucleus	GO:0042306	28	0.036
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.036
post embryonic appendage morphogenesis	GO:0035120	385	0.036
positive regulation of phosphate metabolic process	GO:0045937	139	0.035
positive regulation of endopeptidase activity	GO:0010950	26	0.035
imaginal disc derived appendage development	GO:0048737	399	0.035
cell migration	GO:0016477	238	0.035
regulation of antimicrobial humoral response	GO:0002759	50	0.035	Fly
positive regulation of peptidase activity	GO:0010952	29	0.034
spermatid development	GO:0007286	98	0.034
regulation of cell death	GO:0010941	173	0.034
organelle fission	GO:0048285	340	0.034
muscle cell differentiation	GO:0042692	103	0.033
ion transmembrane transport	GO:0034220	122	0.033
negative regulation of cell cycle	GO:0045786	116	0.033
regulation of cell cycle process	GO:0010564	181	0.033
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.033
positive regulation of protein metabolic process	GO:0051247	128	0.032
cell cycle checkpoint	GO:0000075	95	0.032
regulation of defense response to virus	GO:0050688	14	0.032
regulation of cellular response to stress	GO:0080135	89	0.032	Fly
single organism cellular localization	GO:1902580	180	0.032
negative regulation of cellular protein metabolic process	GO:0032269	85	0.032
negative regulation of response to stimulus	GO:0048585	258	0.031	Fly
protein processing	GO:0016485	68	0.031
phosphorylation	GO:0016310	294	0.031	Fly
appendage morphogenesis	GO:0035107	397	0.031
response to hydrogen peroxide	GO:0042542	11	0.031
positive regulation of protein import into nucleus	GO:0042307	21	0.031
defense response to other organism	GO:0098542	225	0.031
dna metabolic process	GO:0006259	227	0.031
single organism intracellular transport	GO:1902582	207	0.031
appendage development	GO:0048736	401	0.030
eye morphogenesis	GO:0048592	260	0.030
cytoplasmic transport	GO:0016482	130	0.030
negative regulation of protein metabolic process	GO:0051248	85	0.030
protein modification process	GO:0036211	438	0.030
positive regulation of response to external stimulus	GO:0032103	44	0.030	Fly
transcription from rna polymerase ii promoter	GO:0006366	368	0.030
cell maturation	GO:0048469	144	0.030
regulation of phosphorus metabolic process	GO:0051174	210	0.029	Fly
positive regulation of humoral immune response	GO:0002922	28	0.029	Fly
response to temperature stimulus	GO:0009266	106	0.029
regulation of nucleocytoplasmic transport	GO:0046822	35	0.029
response to metal ion	GO:0010038	23	0.029
regulation of system process	GO:0044057	36	0.029
antimicrobial peptide biosynthetic process	GO:0002777	38	0.029	Fly
muscle organ development	GO:0007517	127	0.029
negative regulation of developmental process	GO:0051093	201	0.029
organonitrogen compound metabolic process	GO:1901564	318	0.029	Fly
response to oxygen radical	GO:0000305	3	0.029
organic substance transport	GO:0071702	257	0.029	Fly
forebrain development	GO:0030900	2	0.028
actin cytoskeleton organization	GO:0030036	206	0.028
positive regulation of antibacterial peptide production	GO:0002803	20	0.027	Fly
cellular response to chemical stimulus	GO:0070887	199	0.027	Fly
eggshell formation	GO:0030703	105	0.027
imaginal disc derived wing morphogenesis	GO:0007476	337	0.027
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.027
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.027
chromatin remodeling	GO:0006338	72	0.026
positive regulation of protein transport	GO:0051222	37	0.026
regulation of developmental pigmentation	GO:0048070	24	0.026
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	16	0.026
positive regulation of antimicrobial humoral response	GO:0002760	28	0.026	Fly
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.026
response to glucose	GO:0009749	2	0.025
regulation of intracellular transport	GO:0032386	64	0.024
negative regulation of cellular biosynthetic process	GO:0031327	277	0.024
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.024
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.024
cellular catabolic process	GO:0044248	372	0.024
striated muscle cell differentiation	GO:0051146	90	0.024
nitrogen compound transport	GO:0071705	85	0.024	Fly
digestive tract morphogenesis	GO:0048546	127	0.024
positive regulation of cell death	GO:0010942	69	0.023
genital disc development	GO:0035215	44	0.023
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.023
necrotic cell death	GO:0070265	1	0.023
connective tissue development	GO:0061448	3	0.023
response to organophosphorus	GO:0046683	2	0.023
response to radiation	GO:0009314	155	0.023
eye development	GO:0001654	323	0.023
positive regulation of apoptotic process	GO:0043065	47	0.023
cuticle development	GO:0042335	86	0.022
positive regulation of immune response	GO:0050778	63	0.022
regulation of anatomical structure size	GO:0090066	163	0.022
myotube cell development	GO:0014904	3	0.022
antimicrobial peptide production	GO:0002775	46	0.022	Fly
regulation of antibacterial peptide production	GO:0002786	22	0.022	Fly
immune effector process	GO:0002252	98	0.022	Fly
central nervous system development	GO:0007417	201	0.022
positive regulation of protein localization to nucleus	GO:1900182	21	0.022
negative regulation of biosynthetic process	GO:0009890	277	0.021
organophosphate catabolic process	GO:0046434	112	0.021
regulation of protein transport	GO:0051223	57	0.021
telencephalon development	GO:0021537	2	0.021
chromatin organization	GO:0006325	207	0.021
actin filament based process	GO:0030029	220	0.021
respiratory system development	GO:0060541	213	0.021
negative regulation of mitotic cell cycle	GO:0045930	109	0.021
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.021	Fly
positive regulation of response to biotic stimulus	GO:0002833	31	0.021	Fly
protein targeting to nucleus	GO:0044744	51	0.021
response to monosaccharide	GO:0034284	4	0.021
protein import	GO:0017038	55	0.021
negative regulation of cell differentiation	GO:0045596	143	0.021
organonitrogen compound catabolic process	GO:1901565	128	0.021	Fly
single organism catabolic process	GO:0044712	228	0.021
positive regulation of antimicrobial peptide production	GO:0002225	28	0.021	Fly
secondary metabolic process	GO:0019748	75	0.021	Fly
response to light stimulus	GO:0009416	124	0.020
muscle cell development	GO:0055001	50	0.020
positive regulation of intracellular transport	GO:0032388	42	0.020
regulation of defense response	GO:0031347	102	0.020
regulation of cellular component size	GO:0032535	98	0.020
positive regulation of multi organism process	GO:0043902	40	0.020	Fly
cellular response to extracellular stimulus	GO:0031668	64	0.020
positive regulation of canonical wnt signaling pathway	GO:0090263	7	0.020
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.020
epithelial cell differentiation	GO:0030855	322	0.020
lipid biosynthetic process	GO:0008610	46	0.020
carboxylic acid metabolic process	GO:0019752	92	0.020
stem cell differentiation	GO:0048863	117	0.020
mitotic spindle organization	GO:0007052	220	0.019
protein catabolic process	GO:0030163	101	0.019
oocyte development	GO:0048599	124	0.019
regulation of antimicrobial peptide production	GO:0002784	44	0.019	Fly
segmentation	GO:0035282	207	0.019
mitotic nuclear division	GO:0007067	213	0.019
regulation of protein localization	GO:0032880	76	0.019
positive regulation of intracellular signal transduction	GO:1902533	116	0.019
membrane organization	GO:0061024	112	0.019
compound eye development	GO:0048749	307	0.019
regulation of protein localization to nucleus	GO:1900180	29	0.019
organophosphate metabolic process	GO:0019637	195	0.019
germ line stem cell maintenance	GO:0030718	50	0.019
regulation of establishment of protein localization	GO:0070201	61	0.019
embryonic morphogenesis	GO:0048598	206	0.019
cellular response to oxidative stress	GO:0034599	28	0.018
cellular amino acid metabolic process	GO:0006520	61	0.018
cellular protein modification process	GO:0006464	438	0.018
g2 dna damage checkpoint	GO:0031572	69	0.018
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.018
extrinsic apoptotic signaling pathway	GO:0097191	1	0.018
cellular response to molecule of bacterial origin	GO:0071219	3	0.018	Fly
synaptic transmission	GO:0007268	288	0.018
protein transport	GO:0015031	155	0.018
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.018
regulation of phosphate metabolic process	GO:0019220	210	0.018	Fly
striated muscle cell development	GO:0055002	50	0.018
protein maturation	GO:0051604	71	0.018
positive regulation of phosphorus metabolic process	GO:0010562	139	0.018
response to nitrogen compound	GO:1901698	90	0.018	Fly
protein import into nucleus	GO:0006606	51	0.018
eggshell chorion assembly	GO:0007306	66	0.017
protein modification by small protein conjugation or removal	GO:0070647	106	0.017
response to copper ion	GO:0046688	4	0.017
response to oxidative stress	GO:0006979	86	0.017
blastoderm segmentation	GO:0007350	159	0.017
cellular response to oxygen containing compound	GO:1901701	79	0.017	Fly
stress activated protein kinase signaling cascade	GO:0031098	55	0.017	Fly
negative regulation of apoptotic process	GO:0043066	63	0.017
positive regulation of intracellular protein transport	GO:0090316	30	0.017
dendrite morphogenesis	GO:0048813	199	0.017
negative regulation of transcription dna templated	GO:0045892	237	0.017
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.017
head development	GO:0060322	135	0.017
intracellular protein transport	GO:0006886	104	0.017
regulation of autophagy	GO:0010506	62	0.017
columnar cuboidal epithelial cell development	GO:0002066	249	0.017
response to lipopolysaccharide	GO:0032496	4	0.016	Fly
amide biosynthetic process	GO:0043604	42	0.016	Fly
positive regulation of cellular protein metabolic process	GO:0032270	118	0.016
dorsal appendage formation	GO:0046843	47	0.016
nucleoside triphosphate catabolic process	GO:0009143	108	0.016
nuclear transport	GO:0051169	72	0.016
response to lipid	GO:0033993	38	0.016	Fly
compound eye morphogenesis	GO:0001745	249	0.016
protein complex assembly	GO:0006461	200	0.016
cognition	GO:0050890	141	0.016
peptide biosynthetic process	GO:0043043	42	0.016	Fly
response to hexose	GO:0009746	3	0.016
peptidoglycan recognition protein signaling pathway	GO:0061057	16	0.016
organic acid metabolic process	GO:0006082	103	0.016
wound healing	GO:0042060	75	0.016
homeostatic process	GO:0042592	199	0.015
protein phosphorylation	GO:0006468	169	0.015
regulation of hydrolase activity	GO:0051336	97	0.015
chromatin modification	GO:0016568	147	0.015
heterocycle catabolic process	GO:0046700	166	0.015
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.015
negative regulation of cell death	GO:0060548	81	0.015
stem cell maintenance	GO:0019827	67	0.015
regulation of mapk cascade	GO:0043408	92	0.015	Fly
lateral inhibition	GO:0046331	206	0.015
digestive tract development	GO:0048565	149	0.015
cell type specific apoptotic process	GO:0097285	38	0.015
regulation of cellular component biogenesis	GO:0044087	201	0.015
response to peptide	GO:1901652	29	0.015
gene silencing	GO:0016458	138	0.015
negative regulation of signaling	GO:0023057	219	0.014	Fly
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.014	Fly
carbohydrate metabolic process	GO:0005975	82	0.014
positive regulation of proteolysis	GO:0045862	52	0.014
response to superoxide	GO:0000303	3	0.014
negative regulation of multicellular organismal process	GO:0051241	142	0.014
establishment of protein localization	GO:0045184	163	0.014
spindle organization	GO:0007051	253	0.014
regulation of protein processing	GO:0070613	32	0.014
negative regulation of immune system process	GO:0002683	50	0.014	Fly
cellular amide metabolic process	GO:0043603	80	0.014	Fly
response to organic cyclic compound	GO:0014070	89	0.014
negative regulation of immune response	GO:0050777	39	0.014	Fly
signal transduction in response to dna damage	GO:0042770	3	0.014
response to reactive oxygen species	GO:0000302	24	0.014
response to wounding	GO:0009611	94	0.014
negative regulation of innate immune response	GO:0045824	30	0.014	Fly
regulation of protein targeting	GO:1903533	29	0.014
cell aging	GO:0007569	2	0.014
organ or tissue specific immune response	GO:0002251	10	0.014
nucleobase containing small molecule metabolic process	GO:0055086	174	0.014
embryonic pattern specification	GO:0009880	174	0.014
apoptotic signaling pathway	GO:0097190	27	0.014
positive regulation of rna biosynthetic process	GO:1902680	266	0.014
positive regulation of transport	GO:0051050	92	0.013
epiboly involved in wound healing	GO:0090505	2	0.013
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.013	Fly
negative regulation of growth	GO:0045926	84	0.013
cellular response to arsenic containing substance	GO:0071243	6	0.013
protein modification by small protein conjugation	GO:0032446	79	0.013
positive regulation of cell motility	GO:2000147	3	0.013
gonad development	GO:0008406	50	0.013
cellular response to organic substance	GO:0071310	132	0.013	Fly
regulation of mrna splicing via spliceosome	GO:0048024	64	0.013
modification dependent protein catabolic process	GO:0019941	78	0.013
antibacterial peptide production	GO:0002778	22	0.013	Fly
regulation of cell differentiation	GO:0045595	302	0.013
purine nucleoside metabolic process	GO:0042278	127	0.013
endoderm formation	GO:0001706	3	0.013
establishment or maintenance of cell polarity	GO:0007163	167	0.013
nucleocytoplasmic transport	GO:0006913	72	0.013
digestive system development	GO:0055123	149	0.013
purine ribonucleoside catabolic process	GO:0046130	112	0.013
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.013
regulation of intracellular signal transduction	GO:1902531	236	0.013	Fly
response to endogenous stimulus	GO:0009719	119	0.013	Fly
cellular response to peptide hormone stimulus	GO:0071375	28	0.013
macromolecule catabolic process	GO:0009057	161	0.013	Fly
negative regulation of rna metabolic process	GO:0051253	251	0.013
cellular response to nutrient levels	GO:0031669	62	0.013
positive regulation of antimicrobial peptide biosynthetic process	GO:0002807	26	0.013	Fly
regulation of cell size	GO:0008361	63	0.013
pole plasm assembly	GO:0007315	61	0.013
glycosyl compound catabolic process	GO:1901658	112	0.013
salivary gland cell autophagic cell death	GO:0035071	83	0.013
nucleoside phosphate metabolic process	GO:0006753	162	0.013
stress activated mapk cascade	GO:0051403	52	0.013	Fly
negative regulation of programmed cell death	GO:0043069	72	0.013
ovarian follicle cell development	GO:0030707	248	0.012
organic hydroxy compound metabolic process	GO:1901615	83	0.012	Fly
cellular macromolecule localization	GO:0070727	220	0.012
negative regulation of proteolysis	GO:0045861	31	0.012
signal transduction by phosphorylation	GO:0023014	107	0.012	Fly
female gonad development	GO:0008585	12	0.012
regulation of vesicle mediated transport	GO:0060627	59	0.012
tube morphogenesis	GO:0035239	191	0.012
regulation of behavior	GO:0050795	75	0.012
anterior posterior axis specification	GO:0009948	109	0.012
positive regulation of cell migration	GO:0030335	2	0.012
dna damage checkpoint	GO:0000077	78	0.012
photoreceptor cell differentiation	GO:0046530	170	0.012
ribonucleoside metabolic process	GO:0009119	127	0.012
epithelial cell development	GO:0002064	274	0.012
collateral sprouting of injured axon	GO:0048674	3	0.012
cellular homeostasis	GO:0019725	80	0.012
protein targeting	GO:0006605	64	0.012
inorganic ion transmembrane transport	GO:0098660	73	0.012
lipid metabolic process	GO:0006629	121	0.012
salivary gland development	GO:0007431	162	0.012
regulation of synapse structure and activity	GO:0050803	128	0.012
pigment metabolic process	GO:0042440	84	0.012	Fly
peptidyl amino acid modification	GO:0018193	105	0.012
camera type eye development	GO:0043010	4	0.012
ion homeostasis	GO:0050801	55	0.011
hormone catabolic process	GO:0042447	3	0.011
regulation of rna splicing	GO:0043484	69	0.011
reactive oxygen species metabolic process	GO:0072593	22	0.011
skeletal muscle fiber development	GO:0048741	3	0.011
regulation of translation	GO:0006417	56	0.011
mapk cascade	GO:0000165	107	0.011	Fly
atp metabolic process	GO:0046034	49	0.011
dna dependent dna replication	GO:0006261	17	0.011
tissue morphogenesis	GO:0048729	297	0.011
localization of cell	GO:0051674	257	0.011
cellular chemical homeostasis	GO:0055082	40	0.011
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.011
regulation of catabolic process	GO:0009894	170	0.011
dendrite development	GO:0016358	204	0.011
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO:0070059	4	0.011
pattern recognition receptor signaling pathway	GO:0002221	2	0.011	Fly
androgen metabolic process	GO:0008209	1	0.011
protein ubiquitination	GO:0016567	70	0.011
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.011
transition metal ion transport	GO:0000041	16	0.011
establishment of protein localization to organelle	GO:0072594	62	0.011
positive regulation of mapk cascade	GO:0043410	63	0.011
regulation of molecular function	GO:0065009	217	0.011
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.011
organelle assembly	GO:0070925	198	0.011
positive regulation of cellular amide metabolic process	GO:0034250	26	0.011	Fly
regulation of mitotic cell cycle	GO:0007346	190	0.011
reproductive structure development	GO:0048608	74	0.011
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.011
i kappab phosphorylation	GO:0007252	3	0.011
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.011
negative regulation of protein processing	GO:0010955	31	0.011
cellular ketone metabolic process	GO:0042180	24	0.011
negative regulation of rna biosynthetic process	GO:1902679	240	0.011
positive regulation of defense response	GO:0031349	59	0.010
morphogenesis of an epithelium	GO:0002009	276	0.010
positive regulation of phosphorylation	GO:0042327	87	0.010
purine containing compound metabolic process	GO:0072521	155	0.010
chromosome segregation	GO:0007059	157	0.010
cell cycle arrest	GO:0007050	4	0.010
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.010
adult behavior	GO:0030534	137	0.010
negative regulation of catalytic activity	GO:0043086	42	0.010
single organism carbohydrate metabolic process	GO:0044723	72	0.010
regulation of phosphorylation	GO:0042325	147	0.010	Fly
cellular lipid metabolic process	GO:0044255	83	0.010
protein heterooligomerization	GO:0051291	4	0.010
asymmetric cell division	GO:0008356	37	0.010

PGRP-LE disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.045
disease of cellular proliferation	DOID:14566	0.019
cancer	DOID:162	0.019
central nervous system disease	DOID:331	0.010
nervous system disease	DOID:863	0.010

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network