Drosophila melanogaster

79 known processes

toe (Dmel_CG10704)

twin of eyg

(Aliases: anon-WO0172774.89,Dmel\CG10704,Toe,CG10704)

toe biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
establishment of planar polarityGO:0001736870.434
positive regulation of macromolecule biosynthetic processGO:00105572830.423
Fly
establishment of ommatidial planar polarityGO:0042067490.360
cellular component assembly involved in morphogenesisGO:00109271510.342
compound eye developmentGO:00487493070.325
muscle cell differentiationGO:00426921030.309
negative regulation of nitrogen compound metabolic processGO:00511722650.305
ovarian follicle cell developmentGO:00307072480.245
chorion containing eggshell formationGO:00073041050.232
positive regulation of rna metabolic processGO:00512542710.232
Fly
epithelial cell differentiationGO:00308553220.222
establishment or maintenance of cell polarityGO:00071631670.221
morphogenesis of a polarized epitheliumGO:0001738930.220
positive regulation of nucleic acid templated transcriptionGO:19035082660.220
Fly
sensory organ morphogenesisGO:00905962600.214
Fly
regulation of transcription from rna polymerase ii promoterGO:00063573780.194
negative regulation of rna metabolic processGO:00512532510.191
eye developmentGO:00016543230.184
positive regulation of rna biosynthetic processGO:19026802660.183
Fly
regulation of nervous system developmentGO:00519602480.171
positive regulation of macromolecule metabolic processGO:00106044050.167
Fly
negative regulation of nucleic acid templated transcriptionGO:19035072400.166
central nervous system developmentGO:00074172010.161
Fly
regulation of multicellular organismal developmentGO:20000264140.158
transcription from rna polymerase ii promoterGO:00063663680.156
dorsal appendage formationGO:0046843470.154
negative regulation of cellular biosynthetic processGO:00313272770.146
growthGO:00400073590.145
Fly
eye morphogenesisGO:00485922600.145
Fly
morphogenesis of an epitheliumGO:00020092760.145
establishment of tissue polarityGO:0007164870.140
lateral inhibitionGO:00463312060.137
adult behaviorGO:00305341370.137
Fly
regulation of cell developmentGO:00602842150.135
regulation of cell differentiationGO:00455953020.129
appendage morphogenesisGO:00351073970.129
Fly
renal tubule developmentGO:0061326640.128
negative regulation of response to stimulusGO:00485852580.127
negative regulation of cellular metabolic processGO:00313243820.127
muscle structure developmentGO:00610612240.120
negative regulation of macromolecule biosynthetic processGO:00105582700.119
malpighian tubule developmentGO:0072002640.119
regulation of anatomical structure morphogenesisGO:00226032420.118
appendage developmentGO:00487364010.116
Fly
columnar cuboidal epithelial cell differentiationGO:00020652560.114
neurological system processGO:00508773580.114
positive regulation of nitrogen compound metabolic processGO:00511733540.110
Fly
epithelial cell developmentGO:00020642740.108
positive regulation of nucleobase containing compound metabolic processGO:00459353320.108
Fly
cell migrationGO:00164772380.105
Fly
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.098
dendrite developmentGO:00163582040.098
negative regulation of rna biosynthetic processGO:19026792400.098
wnt signaling pathwayGO:0016055980.097
taxisGO:00423303040.097
axonogenesisGO:00074092900.097
imaginal disc derived wing morphogenesisGO:00074763370.092
neuron projection guidanceGO:00974852410.091
post embryonic appendage morphogenesisGO:00351203850.091
compound eye morphogenesisGO:00017452490.090
Fly
single organism behaviorGO:00447083910.089
Fly
negative regulation of biosynthetic processGO:00098902770.088
anterior posterior pattern specificationGO:00099521360.087
positive regulation of transcription dna templatedGO:00458932660.087
Fly
negative regulation of gene expressionGO:00106293870.086
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.083
negative regulation of transcription dna templatedGO:00458922370.083
embryonic morphogenesisGO:00485982060.083
axon guidanceGO:00074112330.082
columnar cuboidal epithelial cell developmentGO:00020662490.081
spermatid differentiationGO:00485151140.081
imaginal disc derived appendage morphogenesisGO:00351143950.080
Fly
imaginal disc derived appendage developmentGO:00487373990.080
Fly
compound eye photoreceptor cell differentiationGO:00017511400.078
negative regulation of nucleobase containing compound metabolic processGO:00459342610.077
eggshell formationGO:00307031050.074
dorsal closureGO:0007391790.071
embryonic development via the syncytial blastodermGO:00017001480.071
eggshell chorion assemblyGO:0007306660.070
multi organism behaviorGO:00517051750.069
regulation of cell morphogenesisGO:00226041630.069
body morphogenesisGO:001017120.068
leg disc developmentGO:0035218920.067
axon developmentGO:00615642970.066
wing disc morphogenesisGO:00074723440.066
adult locomotory behaviorGO:0008344760.064
Fly
regulation of organelle organizationGO:00330431960.064
intracellular signal transductionGO:00355563000.061
cellular catabolic processGO:00442483720.061
digestive system developmentGO:00551231490.060
tissue morphogenesisGO:00487292970.059
forebrain developmentGO:003090020.059
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.057
Fly
dendrite morphogenesisGO:00488131990.057
cell cell signaling involved in cell fate commitmentGO:00451682100.057
synaptic transmissionGO:00072682880.056
eye photoreceptor cell differentiationGO:00017541450.055
spermatogenesisGO:00072832000.055
regulation of developmental growthGO:00486381740.054
Fly
camera type eye developmentGO:004301040.053
spermatid developmentGO:0007286980.053
regionalizationGO:00030024160.052
brain developmentGO:00074201200.052
Fly
response to external biotic stimulusGO:00432072930.051
negative regulation of cell differentiationGO:00455961430.051
positive regulation of cellular biosynthetic processGO:00313283160.051
Fly
muscle fiber developmentGO:0048747120.049
embryo development ending in birth or egg hatchingGO:00097921520.049
kidney developmentGO:000182230.048
mating behaviorGO:00076171060.047
carboxylic acid metabolic processGO:0019752920.047
notch signaling pathwayGO:00072191200.047
imaginal disc derived wing vein specificationGO:0007474480.047
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.047
Fly
multi organism reproductive behaviorGO:00447051210.046
positive regulation of biosynthetic processGO:00098913160.045
Fly
muscle cell developmentGO:0055001500.045
regulation of notch signaling pathwayGO:00085931000.044
peripheral nervous system developmentGO:0007422520.044
organic substance transportGO:00717022570.044
cell fate specificationGO:0001708710.044
Fly
cardiovascular system developmentGO:0072358820.043
organ growthGO:0035265560.041
head developmentGO:00603221350.041
Fly
positive regulation of gene expressionGO:00106282900.041
Fly
tube morphogenesisGO:00352391910.041
regulation of cellular protein metabolic processGO:00322682430.041
chromosome organizationGO:00512763600.041
antennal developmentGO:0007469250.040
Fly
actin filament based processGO:00300292200.040
digestive tract developmentGO:00485651490.040
regulation of neuron differentiationGO:00456641030.039
actin cytoskeleton organizationGO:00300362060.039
formation of anatomical boundaryGO:0048859370.038
proteolysisGO:00065081920.038
cell motilityGO:00488702510.038
Fly
muscle tissue developmentGO:0060537300.038
photoreceptor cell fate commitmentGO:0046552410.038
Fly
response to organic substanceGO:00100332840.036
negative regulation of cell communicationGO:00106482230.036
negative regulation of signal transductionGO:00099682060.035
organic substance catabolic processGO:19015753080.035
posttranscriptional regulation of gene expressionGO:00106081450.035
compound eye photoreceptor fate commitmentGO:0001752360.035
urogenital system developmentGO:0001655720.034
protein localizationGO:00081042840.034
carbohydrate metabolic processGO:0005975820.034
multi multicellular organism processGO:00447061230.034
regulation of growthGO:00400082330.033
Fly
oxoacid metabolic processGO:00434361030.033
neural retina developmentGO:000340740.033
programmed cell deathGO:00125012570.033
stem cell maintenanceGO:0019827670.032
developmental growthGO:00485892800.032
Fly
locomotory behaviorGO:00076261760.032
Fly
cell growthGO:00160491080.032
chemotaxisGO:00069352490.032
male gamete generationGO:00482322010.032
regulation of wnt signaling pathwayGO:0030111680.031
defense responseGO:00069523000.031
imaginal disc derived leg morphogenesisGO:0007480800.030
telencephalon developmentGO:002153720.030
tube developmentGO:00352952440.030
embryonic hindgut morphogenesisGO:0048619480.030
aggressive behaviorGO:0002118630.030
negative regulation of developmental processGO:00510932010.030
organelle fissionGO:00482853400.030
heterocycle catabolic processGO:00467001660.030
cell deathGO:00082192790.030
nucleobase containing compound catabolic processGO:00346551650.030
catabolic processGO:00090564090.029
skeletal muscle fiber developmentGO:004874130.029
phagocytosisGO:00069092150.029
deathGO:00162652840.028
multicellular organismal reproductive behaviorGO:00330571100.028
localization of cellGO:00516742570.028
Fly
photoreceptor cell differentiationGO:00465301700.028
Fly
actin filament organizationGO:00070151260.028
antimicrobial humoral responseGO:0019730990.028
regulation of molecular functionGO:00650092170.028
striated muscle cell developmentGO:0055002500.028
response to other organismGO:00517072930.027
memoryGO:0007613940.027
regulation of neurogenesisGO:00507671580.027
single organism biosynthetic processGO:00447112060.027
organic acid metabolic processGO:00060821030.027
eye antennal disc developmentGO:0035214600.026
Fly
single organism catabolic processGO:00447122280.026
regulation of response to stressGO:00801342000.026
negative regulation of growthGO:0045926840.026
circulatory system developmentGO:0072359820.026
regulation of cellular ketone metabolic processGO:001056530.026
response to biotic stimulusGO:00096072940.026
morphogenesis of embryonic epitheliumGO:0016331940.026
regulation of cell fate specificationGO:0042659270.025
courtship behaviorGO:0007619680.025
positive regulation of developmental processGO:00510941430.025
Fly
renal system developmentGO:0072001720.025
lipid metabolic processGO:00066291210.025
regulation of mitotic cell cycleGO:00073461900.025
vesicle mediated transportGO:00161923810.025
establishment of localization in cellGO:00516494020.024
pigmentationGO:0043473750.024
response to oxygen containing compoundGO:19017002000.024
organic cyclic compound catabolic processGO:19013611680.024
branching morphogenesis of an epithelial tubeGO:0048754450.024
neuron recognitionGO:00080381010.024
matingGO:00076181200.024
epidermal growth factor receptor signaling pathwayGO:0007173580.024
cellular protein modification processGO:00064644380.023
myoblast fusionGO:0007520430.023
positive regulation of response to stimulusGO:00485843230.023
gland morphogenesisGO:00226121450.023
negative regulation of erbb signaling pathwayGO:1901185290.023
epidermis developmentGO:0008544650.023
immune system processGO:00023763470.023
limb morphogenesisGO:003510810.022
striated muscle cell differentiationGO:0051146900.022
heart developmentGO:0007507820.022
imaginal disc pattern formationGO:0007447910.022
learning or memoryGO:00076111410.022
regulation of reproductive processGO:2000241540.022
regulation of cytoskeleton organizationGO:0051493890.022
eye pigment granule organizationGO:0008057120.022
positive regulation of protein metabolic processGO:00512471280.021
stem cell developmentGO:0048864790.021
cell fate determinationGO:0001709910.021
macromolecule catabolic processGO:00090571610.021
cell fate commitment involved in pattern specificationGO:0060581310.021
response to alcoholGO:0097305950.021
purine ribonucleoside metabolic processGO:00461281270.021
protein complex assemblyGO:00064612000.021
gland developmentGO:00487321910.020
regulation of multi organism processGO:00439001310.020
immune responseGO:00069552460.020
organonitrogen compound metabolic processGO:19015643180.020
connective tissue developmentGO:006144830.020
myotube differentiationGO:0014902460.020
glial cell migrationGO:0008347310.020
Fly
muscle organ developmentGO:00075171270.020
protein complex biogenesisGO:00702712010.020
aromatic compound catabolic processGO:00194391660.020
stem cell differentiationGO:00488631170.020
cellular macromolecule localizationGO:00707272200.019
protein modification processGO:00362114380.019
negative regulation of cellular component organizationGO:00511291080.019
regulation of erbb signaling pathwayGO:1901184420.019
positive regulation of signalingGO:00230562430.019
lymph gland developmentGO:0048542280.019
morphogenesis of a branching structureGO:0001763450.019
regulation of cellular component biogenesisGO:00440872010.019
skeletal muscle organ developmentGO:0060538480.019
small gtpase mediated signal transductionGO:0007264880.018
positive regulation of proteolysisGO:0045862520.018
epithelial tube morphogenesisGO:0060562880.018
regulation of muscle organ developmentGO:0048634130.018
wing and notum subfield formationGO:0035309130.018
reproductive behaviorGO:00190981220.018
regulation of circadian rhythmGO:0042752490.018
anterior posterior axis specificationGO:00099481090.018
positive regulation of catabolic processGO:00098961050.018
negative regulation of organ growthGO:0046621150.018
organonitrogen compound biosynthetic processGO:19015661170.018
cellular nitrogen compound catabolic processGO:00442701650.018
regulation of cell cycle processGO:00105641810.018
cell proliferationGO:00082832990.018
small molecule metabolic processGO:00442813050.018
regulation of cell proliferationGO:00421271630.018
regulation of protein metabolic processGO:00512462560.018
cellular amine metabolic processGO:0044106120.018
striated muscle tissue developmentGO:0014706270.017
male mating behaviorGO:0060179700.017
regulation of cellular amino acid metabolic processGO:000652100.017
response to lipopolysaccharideGO:003249640.017
oxidation reduction processGO:00551141230.017
translationGO:0006412690.017
cellular ketone metabolic processGO:0042180240.017
multicellular organism growthGO:0035264460.017
Fly
cell adhesionGO:00071551360.017
embryonic axis specificationGO:00005781070.017
positive regulation of cell communicationGO:00106472500.017
gastrulation involving germ band extensionGO:0010004360.017
antennal morphogenesisGO:0048800140.017
response to organophosphorusGO:004668320.017
eye photoreceptor cell fate commitmentGO:0042706370.017
response to nutrient levelsGO:00316671140.017
equator specificationGO:004531740.017
cellular lipid metabolic processGO:0044255830.017
regulation of localizationGO:00328792750.017
positive regulation of cellular catabolic processGO:0031331950.016
cellular response to extracellular stimulusGO:0031668640.016
positive regulation of neurogenesisGO:0050769410.016
negative regulation of cell developmentGO:0010721620.016
response to starvationGO:0042594970.016
apoptotic processGO:00069151590.016
smoothened signaling pathwayGO:0007224490.016
positive regulation of nervous system developmentGO:0051962690.016
segment specificationGO:0007379330.016
negative regulation of signalingGO:00230572190.016
macromolecular complex assemblyGO:00650032560.016
camera type eye morphogenesisGO:004859320.016
regulation of cell deathGO:00109411730.016
response to organic cyclic compoundGO:0014070890.016
nuclear divisionGO:00002803320.016
regulation of phosphorus metabolic processGO:00511742100.016
regulation of programmed cell deathGO:00430671520.016
hindgut morphogenesisGO:0007442580.016
cellular response to organic substanceGO:00713101320.016
regulation of organ morphogenesisGO:2000027780.016
embryonic pattern specificationGO:00098801740.016
salivary gland developmentGO:00074311620.016
anterior posterior axis specification embryoGO:00085951030.016
gene silencingGO:00164581380.016
humoral immune responseGO:00069591170.016
positive regulation of molecular functionGO:00440931360.015
larval developmentGO:00021641040.015
positive regulation of cellular protein metabolic processGO:00322701180.015
regulation of epidermal growth factor receptor signaling pathwayGO:0042058420.015
regulation of immune effector processGO:0002697520.015
limb developmentGO:006017310.015
immune effector processGO:0002252980.015
open tracheal system developmentGO:00074242040.015
kidney morphogenesisGO:006099330.015
muscle cell fate commitmentGO:0042693140.015
regulation of catabolic processGO:00098941700.015
cellular response to dna damage stimulusGO:00069742230.015
negative regulation of epidermal growth factor receptor signaling pathwayGO:0042059290.015
positive regulation of catalytic activityGO:00430851180.015
stress activated protein kinase signaling cascadeGO:0031098550.015
amine metabolic processGO:0009308120.015
regulation of translationGO:0006417560.015
cuticle pattern formationGO:0035017270.015
endocytosisGO:00068973100.015
nucleoside catabolic processGO:00091641120.015
vitamin metabolic processGO:000676620.015
organelle assemblyGO:00709251980.015
jnk cascadeGO:0007254500.015
regulation of epithelial cell differentiationGO:003085640.015
chaeta developmentGO:0022416970.015
branch fusion open tracheal systemGO:0035147170.015
chaeta morphogenesisGO:0008407420.015
nuclear importGO:0051170510.015
regulation of muscle cell differentiationGO:005114780.015
peptide metabolic processGO:0006518800.015
positive regulation of cell differentiationGO:0045597640.015
cardiocyte differentiationGO:0035051290.015
cellular amino acid metabolic processGO:0006520610.015
maintenance of locationGO:0051235730.015
circadian rhythmGO:00076231050.015
regulation of anatomical structure sizeGO:00900661630.015
cellular response to external stimulusGO:0071496660.014
negative regulation of sequence specific dna binding transcription factor activityGO:004343340.014
positive regulation of cell motilityGO:200014730.014
respiratory system developmentGO:00605412130.014
single organism cellular localizationGO:19025801800.014
regulation of apoptotic processGO:00429811300.014
nephron tubule developmentGO:007208030.014
cellular response to chemical stimulusGO:00708871990.014
behavioral response to ethanolGO:0048149490.014
negative regulation of intracellular signal transductionGO:1902532570.014
neuroblast differentiationGO:0014016290.014
nephron epithelium morphogenesisGO:007208830.014
establishment of protein localizationGO:00451841630.014
sensory organ precursor cell fate determinationGO:0016360190.014
axis specificationGO:00097981670.014
response to woundingGO:0009611940.014
sperm storageGO:0046693100.014
ras protein signal transductionGO:0007265880.014
sensory neuron axon guidanceGO:009737420.014
peptidyl proline hydroxylationGO:001951110.014
segmentationGO:00352822070.014
regulation of cell shapeGO:00083601130.014
neuron fate commitmentGO:0048663500.014
Fly
neuron neuron synaptic transmissionGO:0007270140.014
cell junction organizationGO:0034330570.014
chromosome segregationGO:00070591570.014
kidney epithelium developmentGO:007207330.013
neuron fate determinationGO:004866410.013
regulation of embryonic developmentGO:0045995680.013
myotube cell developmentGO:001490430.013
agingGO:00075681430.013
negative regulation of developmental growthGO:0048640640.013
negative regulation of cell cycle processGO:00109481090.013
retina development in camera type eyeGO:006004140.013
organic hydroxy compound metabolic processGO:1901615830.013
stem cell proliferationGO:0072089880.013
secondary metabolic processGO:0019748750.013
phosphorylationGO:00163102940.013
nephron developmentGO:007200630.013
rna localizationGO:00064031150.013
regulation of i kappab kinase nf kappab signalingGO:004312220.013
stress activated mapk cascadeGO:0051403520.013
regulation of protein localizationGO:0032880760.013
biological adhesionGO:00226101380.013
cellular response to starvationGO:0009267610.013
sterol homeostasisGO:005509240.013
developmental pigmentationGO:0048066680.013
blastoderm segmentationGO:00073501590.013
rhythmic behaviorGO:0007622760.013
negative regulation of multicellular organismal processGO:00512411420.013
cell fate specification involved in pattern specificationGO:006057380.013
single organism cell adhesionGO:0098602470.013
digestive tract morphogenesisGO:00485461270.013
cytoplasmic transportGO:00164821300.013
regulation of intracellular signal transductionGO:19025312360.013
carbohydrate derivative metabolic processGO:19011352170.013
regulation of hydrolase activityGO:0051336970.013
regulation of microtubule cytoskeleton organizationGO:0070507410.013
regulation of ovipositionGO:0046662140.013
defense response to other organismGO:00985422250.013
steroid catabolic processGO:000670610.013
male courtship behaviorGO:0008049630.013
regulation of immune responseGO:00507761180.013
glycosyl compound catabolic processGO:19016581120.013
neuron fate specificationGO:0048665120.013
Fly
positive regulation of hydrolase activityGO:0051345780.012
regulation of humoral immune responseGO:0002920510.012
regulation of insulin like growth factor receptor signaling pathwayGO:004356730.012
Fly
response to abiotic stimulusGO:00096283410.012
tripartite regional subdivisionGO:00073511030.012
positive regulation of signal transductionGO:00099672230.012
regulation of cellular component sizeGO:0032535980.012
hemocyte differentiationGO:0042386380.012
chromatin organizationGO:00063252070.012
chemosensory behaviorGO:00076351060.012
phototransductionGO:0007602520.012
cuticle developmentGO:0042335860.012
signal transduction by phosphorylationGO:00230141070.012
intracellular transportGO:00469072280.012
cell junction assemblyGO:0034329420.012
nucleobase containing small molecule metabolic processGO:00550861740.012
exocrine system developmentGO:00352721620.012
regulation of transportGO:00510491810.012
regulation of cell cycleGO:00517262910.012
negative regulation of cell cycleGO:00457861160.012
regulation of antimicrobial humoral responseGO:0002759500.012
organonitrogen compound catabolic processGO:19015651280.012
mesenchymal cell differentiationGO:004876210.011
hindbrain developmentGO:003090220.011
regulation of mapk cascadeGO:0043408920.011
regulation of cell morphogenesis involved in differentiationGO:0010769610.011
neural precursor cell proliferationGO:0061351750.011
developmental programmed cell deathGO:00106231380.011
olfactory behaviorGO:0042048970.011
regulation of epithelial cell proliferationGO:005067840.011
purine nucleoside catabolic processGO:00061521120.011
regulation of cellular amine metabolic processGO:003323830.011
nucleocytoplasmic transportGO:0006913720.011
mitotic spindle organizationGO:00070522200.011
detection of light stimulusGO:0009583580.011
negative regulation of cell deathGO:0060548810.011
eye pigmentationGO:0048069430.011
cellular response to oxygen containing compoundGO:1901701790.011
hippo signalingGO:0035329200.011
purine ribonucleoside catabolic processGO:00461301120.011
regulation of behaviorGO:0050795750.011
syncytium formationGO:0006949430.011
embryonic organ developmentGO:0048568500.011
positive regulation of notch signaling pathwayGO:0045747340.011
necrotic cell deathGO:007026510.011
chitin based cuticle developmentGO:0040003490.011
intracellular protein transportGO:00068861040.011
mitotic nuclear divisionGO:00070672130.011
negative regulation of cellular protein metabolic processGO:0032269850.011
sex differentiationGO:0007548810.011
renal tubule morphogenesisGO:0061333440.011
tube fusionGO:0035146170.011
negative regulation of apoptotic processGO:0043066630.010
protein localization to nucleusGO:0034504550.010
carbohydrate derivative catabolic processGO:19011361180.010
formation of organ boundaryGO:0010160300.010
cellular protein localizationGO:00346131600.010
germ cell migrationGO:0008354430.010
proteolysis involved in cellular protein catabolic processGO:0051603830.010
response to lipidGO:0033993380.010
ribonucleoside catabolic processGO:00424541120.010
sensory organ boundary specificationGO:0008052220.010
dna metabolic processGO:00062592270.010
rna processingGO:00063961470.010
signal transduction in response to dna damageGO:004277030.010
cellular macromolecule catabolic processGO:00442651360.010
regulation of muscle tissue developmentGO:190186150.010
hindgut developmentGO:0061525580.010
cardiac cell fate commitmentGO:0060911170.010
positive regulation of cell migrationGO:003033520.010
membrane organizationGO:00610241120.010

toe disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.022
disease of anatomical entityDOID:700.022
central nervous system diseaseDOID:33100.011