IMP: Integrative Multi-species Prediction

Drosophila melanogaster

160 known processes

RacGAP84C (Dmel_CG2595)

CG2595 gene product from transcript CG2595-RA

(Aliases: GAP84C,rnprot,rnprot1.7,rnracGap,rnRacGAP,racGAP,rnracGAP,rnGAP,Dmel\CG2595,P1.7,CG2595,RhoGAP-84C8,rnRac-GAP,rnRacGap,RacGAP(84C))

Entrez: 117503
FLYBASE: FBgn0045843
UniProtKB: P40809

Process Predictions
Disease Predictions

RacGAP84C biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
tissue morphogenesis	GO:0048729	297	0.414
morphogenesis of an epithelium	GO:0002009	276	0.298
negative regulation of cellular metabolic process	GO:0031324	382	0.295
negative regulation of biosynthetic process	GO:0009890	277	0.218
compound eye development	GO:0048749	307	0.166
negative regulation of rna metabolic process	GO:0051253	251	0.152
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.150
negative regulation of gene expression	GO:0010629	387	0.148
negative regulation of cellular biosynthetic process	GO:0031327	277	0.113
compound eye morphogenesis	GO:0001745	249	0.108
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.107
localization of cell	GO:0051674	257	0.105
appendage development	GO:0048736	401	0.105
tube morphogenesis	GO:0035239	191	0.104
negative regulation of rna biosynthetic process	GO:1902679	240	0.103
imaginal disc derived appendage development	GO:0048737	399	0.096
neurological system process	GO:0050877	358	0.093
regionalization	GO:0003002	416	0.092
cell division	GO:0051301	248	0.089	Fly
wing disc morphogenesis	GO:0007472	344	0.089
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.089
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.087
negative regulation of transcription dna templated	GO:0045892	237	0.086
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.085
intracellular signal transduction	GO:0035556	300	0.081
tube development	GO:0035295	244	0.077
protein maturation	GO:0051604	71	0.077
dorsal closure	GO:0007391	79	0.077
central nervous system development	GO:0007417	201	0.074
protein localization	GO:0008104	284	0.073	Fly
muscle organ development	GO:0007517	127	0.073
imaginal disc derived wing morphogenesis	GO:0007476	337	0.072
post embryonic appendage morphogenesis	GO:0035120	385	0.070
developmental growth	GO:0048589	280	0.069
growth	GO:0040007	359	0.067
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.064
actin filament based process	GO:0030029	220	0.064
positive regulation of response to stimulus	GO:0048584	323	0.063
eye morphogenesis	GO:0048592	260	0.063
epithelial cell development	GO:0002064	274	0.062
transcription from rna polymerase ii promoter	GO:0006366	368	0.062
negative regulation of cell cycle process	GO:0010948	109	0.061
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.061
muscle structure development	GO:0061061	224	0.061	Fly
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.060
kidney epithelium development	GO:0072073	3	0.060
regulation of mapk cascade	GO:0043408	92	0.060
establishment of localization in cell	GO:0051649	402	0.058
negative regulation of mitotic cell cycle	GO:0045930	109	0.057
positive regulation of cell communication	GO:0010647	250	0.057
embryo development ending in birth or egg hatching	GO:0009792	152	0.056
male gamete generation	GO:0048232	201	0.052
regulation of cell cycle	GO:0051726	291	0.052
kidney morphogenesis	GO:0060993	3	0.052
morphogenesis of embryonic epithelium	GO:0016331	94	0.052
regulation of cell death	GO:0010941	173	0.052
regulation of localization	GO:0032879	275	0.051
actin cytoskeleton organization	GO:0030036	206	0.050
positive regulation of transcription dna templated	GO:0045893	266	0.050
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.050
regulation of transport	GO:0051049	181	0.050
response to other organism	GO:0051707	293	0.049
spermatogenesis	GO:0007283	200	0.049
lateral inhibition	GO:0046331	206	0.049
small molecule metabolic process	GO:0044281	305	0.048
immune system process	GO:0002376	347	0.048
negative regulation of cell communication	GO:0010648	223	0.047	Fly
regulation of phosphorus metabolic process	GO:0051174	210	0.046
dorsal ventral pattern formation	GO:0009953	133	0.046
regulation of cell cycle process	GO:0010564	181	0.045
regulation of molecular function	GO:0065009	217	0.044
positive regulation of signal transduction	GO:0009967	223	0.042
immune response	GO:0006955	246	0.042
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.042
appendage morphogenesis	GO:0035107	397	0.041
intracellular transport	GO:0046907	228	0.041
ovarian follicle cell development	GO:0030707	248	0.040
brain development	GO:0007420	120	0.039
peptidyl threonine phosphorylation	GO:0018107	2	0.039
regulation of intracellular signal transduction	GO:1902531	236	0.038
regulation of nervous system development	GO:0051960	248	0.038
negative regulation of signaling	GO:0023057	219	0.038	Fly
single organism cellular localization	GO:1902580	180	0.037
eye development	GO:0001654	323	0.037
homeostatic process	GO:0042592	199	0.037
cell proliferation	GO:0008283	299	0.037	Mouse Fly
mapk cascade	GO:0000165	107	0.036
defense response	GO:0006952	300	0.036
embryonic morphogenesis	GO:0048598	206	0.036
regulation of catalytic activity	GO:0050790	185	0.036
cell migration	GO:0016477	238	0.036
axis specification	GO:0009798	167	0.035
signal transduction by phosphorylation	GO:0023014	107	0.035
embryonic development via the syncytial blastoderm	GO:0001700	148	0.035
regulation of apoptotic process	GO:0042981	130	0.034
stress activated mapk cascade	GO:0051403	52	0.034
learning or memory	GO:0007611	141	0.033
columnar cuboidal epithelial cell development	GO:0002066	249	0.033
endocytosis	GO:0006897	310	0.033
phosphorylation	GO:0016310	294	0.033
purine ribonucleotide metabolic process	GO:0009150	145	0.033
hindbrain development	GO:0030902	2	0.032
vesicle mediated transport	GO:0016192	381	0.032
positive regulation of immune system process	GO:0002684	68	0.032
epithelial tube morphogenesis	GO:0060562	88	0.032
establishment of tissue polarity	GO:0007164	87	0.031
negative regulation of cell cycle	GO:0045786	116	0.031
regulation of response to stress	GO:0080134	200	0.031
negative regulation of organelle organization	GO:0010639	56	0.031
exocrine system development	GO:0035272	162	0.030
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.030
regulation of cellular localization	GO:0060341	136	0.030
mitotic nuclear division	GO:0007067	213	0.029	Fly
digestive tract morphogenesis	GO:0048546	127	0.029
gland morphogenesis	GO:0022612	145	0.029
stress activated protein kinase signaling cascade	GO:0031098	55	0.029
cell motility	GO:0048870	251	0.029
single organism biosynthetic process	GO:0044711	206	0.028
forebrain development	GO:0030900	2	0.028
lipid metabolic process	GO:0006629	121	0.028
protein processing	GO:0016485	68	0.028
anterior posterior pattern specification	GO:0009952	136	0.028
regulation of mitosis	GO:0007088	56	0.028
morphogenesis of a polarized epithelium	GO:0001738	93	0.028
detection of stimulus	GO:0051606	156	0.028
axonogenesis	GO:0007409	290	0.027
immune response activating signal transduction	GO:0002757	2	0.027
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.027
protein complex biogenesis	GO:0070271	201	0.027	Fly
organic hydroxy compound metabolic process	GO:1901615	83	0.027
regulation of phosphate metabolic process	GO:0019220	210	0.026
protein polymerization	GO:0051258	42	0.026
protein modification process	GO:0036211	438	0.026
regulation of programmed cell death	GO:0043067	152	0.026
epithelial cell differentiation	GO:0030855	322	0.025
organic substance transport	GO:0071702	257	0.025
death	GO:0016265	284	0.025
tissue migration	GO:0090130	155	0.025
positive regulation of phosphate metabolic process	GO:0045937	139	0.024
photoreceptor cell differentiation	GO:0046530	170	0.024
regulation of nuclear division	GO:0051783	58	0.024
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.024
head involution	GO:0008258	35	0.024
regulation of cellular ketone metabolic process	GO:0010565	3	0.023
connective tissue development	GO:0061448	3	0.023
neuromuscular junction development	GO:0007528	149	0.023
positive regulation of macromolecule metabolic process	GO:0010604	405	0.023
purine containing compound metabolic process	GO:0072521	155	0.023
chromosome organization	GO:0051276	360	0.023
nephron tubule development	GO:0072080	3	0.023
tissue homeostasis	GO:0001894	36	0.022
regulation of stress activated mapk cascade	GO:0032872	41	0.022
response to external biotic stimulus	GO:0043207	293	0.022
positive regulation of cellular amine metabolic process	GO:0033240	0	0.022
digestive tract development	GO:0048565	149	0.022
myotube differentiation	GO:0014902	46	0.022
cytoplasmic transport	GO:0016482	130	0.022
cellular macromolecule catabolic process	GO:0044265	136	0.022
positive regulation of signaling	GO:0023056	243	0.022
phosphate ion transport	GO:0006817	4	0.022
regulation of cell projection organization	GO:0031344	92	0.022
nephron morphogenesis	GO:0072028	3	0.021
establishment of protein localization	GO:0045184	163	0.021
circadian behavior	GO:0048512	76	0.021
gland development	GO:0048732	191	0.021
regulation of notch signaling pathway	GO:0008593	100	0.021
embryonic pattern specification	GO:0009880	174	0.021
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.021
single organism intracellular transport	GO:1902582	207	0.021
neuroblast proliferation	GO:0007405	74	0.021	Mouse
synaptic growth at neuromuscular junction	GO:0051124	119	0.021
establishment or maintenance of cell polarity	GO:0007163	167	0.021
positive regulation of phosphorus metabolic process	GO:0010562	139	0.021
purine ribonucleotide catabolic process	GO:0009154	109	0.021
positive regulation of epithelial cell differentiation	GO:0030858	1	0.020
digestive system development	GO:0055123	149	0.020
cognition	GO:0050890	141	0.020
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.020
eye photoreceptor cell differentiation	GO:0001754	145	0.020
apoptotic process	GO:0006915	159	0.020
regulation of jnk cascade	GO:0046328	40	0.020
innate immune response	GO:0045087	144	0.020
jnk cascade	GO:0007254	50	0.020
response to lipopolysaccharide	GO:0032496	4	0.020
negative regulation of response to stimulus	GO:0048585	258	0.019	Fly
regulation of multicellular organismal development	GO:2000026	414	0.019
ribonucleotide metabolic process	GO:0009259	145	0.019
regulation of anatomical structure morphogenesis	GO:0022603	242	0.019
negative regulation of cell death	GO:0060548	81	0.019
regulation of circadian rhythm	GO:0042752	49	0.019
nephron development	GO:0072006	3	0.019
regulation of epithelial cell differentiation	GO:0030856	4	0.019
organophosphate metabolic process	GO:0019637	195	0.019
purine nucleotide metabolic process	GO:0006163	146	0.019
microtubule organizing center organization	GO:0031023	168	0.019	Fly
positive regulation of multicellular organismal process	GO:0051240	143	0.018
secretion	GO:0046903	109	0.018
defense response to other organism	GO:0098542	225	0.018
cuticle development	GO:0042335	86	0.018
small gtpase mediated signal transduction	GO:0007264	88	0.018
skeletal muscle organ development	GO:0060538	48	0.018
establishment of ommatidial planar polarity	GO:0042067	49	0.018
nuclear division	GO:0000280	332	0.018	Fly
regulation of mitotic cell cycle	GO:0007346	190	0.018
response to abiotic stimulus	GO:0009628	341	0.018
actin filament organization	GO:0007015	126	0.018
cellular macromolecular complex assembly	GO:0034622	153	0.018
body morphogenesis	GO:0010171	2	0.018
ras protein signal transduction	GO:0007265	88	0.018
response to organic substance	GO:0010033	284	0.018
head development	GO:0060322	135	0.018
sensory organ morphogenesis	GO:0090596	260	0.018
positive regulation of cellular component biogenesis	GO:0044089	80	0.018
cell death	GO:0008219	279	0.018
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.018
muscle attachment	GO:0016203	36	0.018
regulation of cellular response to stress	GO:0080135	89	0.018
establishment of planar polarity	GO:0001736	87	0.018
positive regulation of programmed cell death	GO:0043068	62	0.017
cellular catabolic process	GO:0044248	372	0.017
dendrite development	GO:0016358	204	0.017	Fly
response to biotic stimulus	GO:0009607	294	0.017
torso signaling pathway	GO:0008293	21	0.017
positive regulation of biosynthetic process	GO:0009891	316	0.017
regulation of organelle organization	GO:0033043	196	0.017	Fly
developmental pigmentation	GO:0048066	68	0.017
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.017
positive regulation of ras gtpase activity	GO:0032320	36	0.017
striated muscle cell development	GO:0055002	50	0.017
nucleoside phosphate metabolic process	GO:0006753	162	0.017
regulation of phosphorylation	GO:0042325	147	0.017
memory	GO:0007613	94	0.017
imaginal disc derived wing vein specification	GO:0007474	48	0.017
cellular amino acid metabolic process	GO:0006520	61	0.017
secretion by cell	GO:0032940	101	0.017
immune system development	GO:0002520	57	0.016
generation of precursor metabolites and energy	GO:0006091	42	0.016
phagocytosis	GO:0006909	215	0.016
imaginal disc pattern formation	GO:0007447	91	0.016
amine metabolic process	GO:0009308	12	0.016
negative regulation of cell division	GO:0051782	17	0.016
immune response regulating signaling pathway	GO:0002764	2	0.016
developmental programmed cell death	GO:0010623	138	0.016
stem cell differentiation	GO:0048863	117	0.016
organic substance catabolic process	GO:1901575	308	0.016
salivary gland morphogenesis	GO:0007435	145	0.016
cellular response to mechanical stimulus	GO:0071260	2	0.016
cell growth	GO:0016049	108	0.016
positive regulation of rna metabolic process	GO:0051254	271	0.016
catabolic process	GO:0009056	409	0.016
response to bacterium	GO:0009617	198	0.016
positive regulation of apoptotic process	GO:0043065	47	0.016
cell cycle phase transition	GO:0044770	140	0.016
wing disc pattern formation	GO:0035222	66	0.016
kidney development	GO:0001822	3	0.016
cellular protein localization	GO:0034613	160	0.015	Fly
positive regulation of cell differentiation	GO:0045597	64	0.015
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.015
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.015
oxoacid metabolic process	GO:0043436	103	0.015
taxis	GO:0042330	304	0.015
cellular amine metabolic process	GO:0044106	12	0.015
regulation of immune system process	GO:0002682	176	0.015
programmed cell death	GO:0012501	257	0.015
morphogenesis of a branching structure	GO:0001763	45	0.015
eye antennal disc development	GO:0035214	60	0.015
molting cycle chitin based cuticle	GO:0007591	56	0.015
protein complex assembly	GO:0006461	200	0.015	Fly
circulatory system development	GO:0072359	82	0.015
organonitrogen compound metabolic process	GO:1901564	318	0.015
regulation of synapse assembly	GO:0051963	94	0.014
response to light stimulus	GO:0009416	124	0.014
epithelial cell migration	GO:0010631	148	0.014
multicellular organismal homeostasis	GO:0048871	41	0.014
dna metabolic process	GO:0006259	227	0.014
peptidyl amino acid modification	GO:0018193	105	0.014
negative regulation of cell cycle phase transition	GO:1901988	103	0.014
positive regulation of cellular component organization	GO:0051130	156	0.014
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.014
regulation of immune response	GO:0050776	118	0.014
epidermis development	GO:0008544	65	0.014
regulation of hydrolase activity	GO:0051336	97	0.014
apoptotic process involved in morphogenesis	GO:0060561	3	0.014
regulation of cell division	GO:0051302	72	0.014
reproductive system development	GO:0061458	74	0.014
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.014
cellular ketone metabolic process	GO:0042180	24	0.014
regulation of cell proliferation	GO:0042127	163	0.014
positive regulation of cell motility	GO:2000147	3	0.014
urogenital system development	GO:0001655	72	0.014
striated muscle cell differentiation	GO:0051146	90	0.014
chitin based cuticle development	GO:0040003	49	0.014
positive regulation of lipid biosynthetic process	GO:0046889	3	0.014
chorion containing eggshell formation	GO:0007304	105	0.014
positive regulation of transport	GO:0051050	92	0.014
regulation of cell differentiation	GO:0045595	302	0.014
ribose phosphate metabolic process	GO:0019693	145	0.013
nephron epithelium morphogenesis	GO:0072088	3	0.013
proteolysis	GO:0006508	192	0.013
cellular macromolecule localization	GO:0070727	220	0.013	Fly
anion transport	GO:0006820	41	0.013
positive regulation of lipid metabolic process	GO:0045834	4	0.013
cellular response to organic substance	GO:0071310	132	0.013
positive regulation of intracellular signal transduction	GO:1902533	116	0.013
cellular protein modification process	GO:0006464	438	0.013
muscle cell development	GO:0055001	50	0.013
leg disc development	GO:0035218	92	0.013
protein localization to organelle	GO:0033365	82	0.013
wound healing	GO:0042060	75	0.013
negative regulation of signal transduction	GO:0009968	206	0.013	Fly
guanosine containing compound catabolic process	GO:1901069	74	0.013
g protein coupled receptor signaling pathway	GO:0007186	136	0.013
intracellular protein transport	GO:0006886	104	0.013
organelle fission	GO:0048285	340	0.013	Fly
salivary gland development	GO:0007431	162	0.012
learning	GO:0007612	75	0.012
regulation of cell cycle phase transition	GO:1901987	130	0.012
negative regulation of cell differentiation	GO:0045596	143	0.012
locomotory behavior	GO:0007626	176	0.012
glycosyl compound catabolic process	GO:1901658	112	0.012
centrosome organization	GO:0051297	163	0.012	Fly
positive regulation of catalytic activity	GO:0043085	118	0.012
purine containing compound catabolic process	GO:0072523	112	0.012
regulation of cellular protein metabolic process	GO:0032268	243	0.012
positive regulation of mapk cascade	GO:0043410	63	0.012
negative regulation of cellular component organization	GO:0051129	108	0.012
macromolecule catabolic process	GO:0009057	161	0.012
response to endogenous stimulus	GO:0009719	119	0.012
response to copper ion	GO:0046688	4	0.012
endodermal cell differentiation	GO:0035987	3	0.012
regulation of cellular amino acid metabolic process	GO:0006521	0	0.012
cellular response to biotic stimulus	GO:0071216	4	0.012
mesenchymal cell differentiation	GO:0048762	1	0.012
cellular response to lipopolysaccharide	GO:0071222	3	0.012
regulation of cellular amine metabolic process	GO:0033238	3	0.012
negative regulation of catalytic activity	GO:0043086	42	0.012
regulation of embryonic development	GO:0045995	68	0.012
nucleotide metabolic process	GO:0009117	161	0.012
positive regulation of protein metabolic process	GO:0051247	128	0.012
negative regulation of molecular function	GO:0044092	51	0.011
neuromuscular synaptic transmission	GO:0007274	67	0.011
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.011
defense response to bacterium	GO:0042742	178	0.011
anatomical structure homeostasis	GO:0060249	97	0.011
single organism catabolic process	GO:0044712	228	0.011
protein catabolic process	GO:0030163	101	0.011
single organism behavior	GO:0044708	391	0.011
regulation of neurogenesis	GO:0050767	158	0.011
establishment of spindle localization	GO:0051293	22	0.011
renal tubule morphogenesis	GO:0061333	44	0.011
positive regulation of molecular function	GO:0044093	136	0.011
negative regulation of protein metabolic process	GO:0051248	85	0.011
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.011
glycosyl compound metabolic process	GO:1901657	127	0.011
peptidyl threonine modification	GO:0018210	3	0.011
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.011
regulation of wnt signaling pathway	GO:0030111	68	0.011	Fly
ion transport	GO:0006811	145	0.011
cellular response to molecule of bacterial origin	GO:0071219	3	0.011
positive regulation of gtpase activity	GO:0043547	43	0.011
rna splicing via transesterification reactions	GO:0000375	73	0.011
nucleoside catabolic process	GO:0009164	112	0.011
gonad development	GO:0008406	50	0.011
organic cyclic compound catabolic process	GO:1901361	168	0.011
positive regulation of developmental process	GO:0051094	143	0.011
anterior posterior axis specification	GO:0009948	109	0.011
positive regulation of immune response	GO:0050778	63	0.010
larval development	GO:0002164	104	0.010
negative regulation of nervous system development	GO:0051961	92	0.010
positive regulation of nervous system development	GO:0051962	69	0.010
purine ribonucleoside catabolic process	GO:0046130	112	0.010
organic hydroxy compound biosynthetic process	GO:1901617	21	0.010
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.010
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.010
negative regulation of developmental process	GO:0051093	201	0.010
stem cell division	GO:0017145	69	0.010
adherens junction organization	GO:0034332	27	0.010
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.010
mitotic cytokinesis	GO:0000281	50	0.010	Fly
morphogenesis of follicular epithelium	GO:0016333	36	0.010
regulation of neuron differentiation	GO:0045664	103	0.010
heterocycle catabolic process	GO:0046700	166	0.010
notch signaling pathway	GO:0007219	120	0.010
hormone biosynthetic process	GO:0042446	20	0.010
macromolecular complex assembly	GO:0065003	256	0.010	Fly
regulation of developmental growth	GO:0048638	174	0.010
regulation of cellular component biogenesis	GO:0044087	201	0.010

RacGAP84C disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.024
disease of cellular proliferation	DOID:14566	0.010
organ system cancer	DOID:0050686	0.010
cancer	DOID:162	0.010

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