IMP: Integrative Multi-species Prediction

Drosophila melanogaster

55 known processes

mfr (Dmel_CG5747)

misfire

(Aliases: Dmel\CG5747,CG5747)

Entrez: 39016
FLYBASE: FBgn0035935
UniProtKB: B7Z0F1
UniProtKB: B7Z0F0
UniProtKB: B7Z0E8
UniProtKB: B7Z0E9
UniProtKB: B7Z0E6
UniProtKB: B7Z0E7
UniProtKB: B7Z0E5

Process Predictions
Disease Predictions

mfr biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
nucleus organization	GO:0006997	45	0.754
single fertilization	GO:0007338	24	0.550
cellular component disassembly	GO:0022411	46	0.244
chromosome organization	GO:0051276	360	0.214
insemination	GO:0007320	22	0.196
sperm competition	GO:0046692	21	0.191
endocytosis	GO:0006897	310	0.175
male pronucleus assembly	GO:0035039	6	0.174
localization of cell	GO:0051674	257	0.159
chromatin organization	GO:0006325	207	0.145
fertilization	GO:0009566	26	0.145
chromatin modification	GO:0016568	147	0.107
vesicle mediated transport	GO:0016192	381	0.093
membrane organization	GO:0061024	112	0.092
organelle assembly	GO:0070925	198	0.089
establishment of localization in cell	GO:0051649	402	0.086
regionalization	GO:0003002	416	0.069
cell motility	GO:0048870	251	0.068
protein dna complex subunit organization	GO:0071824	86	0.063
compound eye development	GO:0048749	307	0.063
organelle fission	GO:0048285	340	0.062
photoreceptor cell differentiation	GO:0046530	170	0.055
single organism behavior	GO:0044708	391	0.054
organic substance transport	GO:0071702	257	0.050
wing disc morphogenesis	GO:0007472	344	0.047
eye development	GO:0001654	323	0.046
endomembrane system organization	GO:0010256	119	0.046
positive regulation of cell communication	GO:0010647	250	0.046
sperm storage	GO:0046693	10	0.045
regulation of localization	GO:0032879	275	0.045
oocyte development	GO:0048599	124	0.044
copulation	GO:0007620	26	0.042
chromatin remodeling	GO:0006338	72	0.041
positive regulation of signal transduction	GO:0009967	223	0.040
neurological system process	GO:0050877	358	0.040
multi multicellular organism process	GO:0044706	123	0.039
ovarian follicle cell development	GO:0030707	248	0.039
developmental maturation	GO:0021700	172	0.038
sensory organ morphogenesis	GO:0090596	260	0.038
mating	GO:0007618	120	0.038
axis specification	GO:0009798	167	0.038
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.037
regulation of transport	GO:0051049	181	0.036
regulation of anatomical structure morphogenesis	GO:0022603	242	0.036
chorion containing eggshell formation	GO:0007304	105	0.036
atp dependent chromatin remodeling	GO:0043044	22	0.034
olfactory behavior	GO:0042048	97	0.034
segmentation	GO:0035282	207	0.033
compound eye morphogenesis	GO:0001745	249	0.032
embryonic pattern specification	GO:0009880	174	0.032
mitotic nuclear division	GO:0007067	213	0.032
male gamete generation	GO:0048232	201	0.031
nuclear division	GO:0000280	332	0.031
transcription from rna polymerase ii promoter	GO:0006366	368	0.031
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.031
intracellular transport	GO:0046907	228	0.030
microtubule organizing center organization	GO:0031023	168	0.030
negative regulation of signaling	GO:0023057	219	0.030
negative regulation of signal transduction	GO:0009968	206	0.030
regulation of multi organism process	GO:0043900	131	0.030
cell maturation	GO:0048469	144	0.029
protein localization	GO:0008104	284	0.029
central nervous system development	GO:0007417	201	0.028
eye morphogenesis	GO:0048592	260	0.028
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.028
protein complex assembly	GO:0006461	200	0.028
appendage development	GO:0048736	401	0.028
positive regulation of signaling	GO:0023056	243	0.028
single organism membrane fusion	GO:0044801	42	0.027
chemosensory behavior	GO:0007635	106	0.027
regulation of catalytic activity	GO:0050790	185	0.026
blastoderm segmentation	GO:0007350	159	0.026
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.026
sleep	GO:0030431	49	0.026
post embryonic appendage morphogenesis	GO:0035120	385	0.026
immune response	GO:0006955	246	0.026
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.025
macromolecule catabolic process	GO:0009057	161	0.025
learning or memory	GO:0007611	141	0.025
negative regulation of response to stimulus	GO:0048585	258	0.025
compound eye photoreceptor cell differentiation	GO:0001751	140	0.025
negative regulation of gene expression	GO:0010629	387	0.025
positive regulation of biosynthetic process	GO:0009891	316	0.025
single organism intracellular transport	GO:1902582	207	0.024
positive regulation of macromolecule metabolic process	GO:0010604	405	0.024
oocyte construction	GO:0007308	112	0.024
compound eye photoreceptor development	GO:0042051	78	0.024
sperm motility	GO:0030317	12	0.024
synaptic transmission	GO:0007268	288	0.024
establishment or maintenance of cell polarity	GO:0007163	167	0.024
dendrite development	GO:0016358	204	0.024
phagocytosis	GO:0006909	215	0.024
homeostatic process	GO:0042592	199	0.023
eye photoreceptor cell differentiation	GO:0001754	145	0.023
epithelial cell development	GO:0002064	274	0.023
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.023
negative regulation of cellular metabolic process	GO:0031324	382	0.023
establishment of protein localization	GO:0045184	163	0.022
axonogenesis	GO:0007409	290	0.022
mitochondrion organization	GO:0007005	65	0.022
plasma membrane organization	GO:0007009	26	0.022
cytoplasmic transport	GO:0016482	130	0.022
imaginal disc derived wing morphogenesis	GO:0007476	337	0.021
anatomical structure homeostasis	GO:0060249	97	0.021
oocyte differentiation	GO:0009994	145	0.021
tissue morphogenesis	GO:0048729	297	0.021
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.021
humoral immune response	GO:0006959	117	0.021
kidney development	GO:0001822	3	0.021
dna metabolic process	GO:0006259	227	0.021
regulation of cellular amine metabolic process	GO:0033238	3	0.020
negative regulation of biosynthetic process	GO:0009890	277	0.020
tube development	GO:0035295	244	0.020
columnar cuboidal epithelial cell development	GO:0002066	249	0.020
cell division	GO:0051301	248	0.020
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.020
digestive tract development	GO:0048565	149	0.020
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.019
negative regulation of cell communication	GO:0010648	223	0.019
catabolic process	GO:0009056	409	0.019
regulation of immune system process	GO:0002682	176	0.019
intracellular signal transduction	GO:0035556	300	0.019
protein modification process	GO:0036211	438	0.019
learning	GO:0007612	75	0.019
regulation of vesicle mediated transport	GO:0060627	59	0.019
forebrain development	GO:0030900	2	0.019
morphogenesis of an epithelium	GO:0002009	276	0.019
microtubule based transport	GO:0010970	42	0.019
cellular protein localization	GO:0034613	160	0.019
embryonic axis specification	GO:0000578	107	0.018
salivary gland development	GO:0007431	162	0.018
regulation of cell cycle	GO:0051726	291	0.018
transmembrane transport	GO:0055085	139	0.018
posttranscriptional gene silencing by rna	GO:0035194	45	0.018
spindle organization	GO:0007051	253	0.018
regulation of cellular localization	GO:0060341	136	0.018
tissue death	GO:0016271	102	0.018
posttranscriptional gene silencing	GO:0016441	46	0.018
regulation of intracellular signal transduction	GO:1902531	236	0.018
organonitrogen compound metabolic process	GO:1901564	318	0.018
centrosome organization	GO:0051297	163	0.018
olfactory learning	GO:0008355	56	0.018
organelle fusion	GO:0048284	46	0.018
adult behavior	GO:0030534	137	0.018
innate immune response	GO:0045087	144	0.017
camera type eye development	GO:0043010	4	0.017
imaginal disc derived appendage development	GO:0048737	399	0.017
gland morphogenesis	GO:0022612	145	0.017
behavioral response to ethanol	GO:0048149	49	0.017
photoreceptor cell development	GO:0042461	96	0.017
regulation of multicellular organismal development	GO:2000026	414	0.017
immune system process	GO:0002376	347	0.017
response to temperature stimulus	GO:0009266	106	0.017
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.017
regulation of molecular function	GO:0065009	217	0.017
oocyte axis specification	GO:0007309	108	0.017
cellular catabolic process	GO:0044248	372	0.017
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.017
appendage morphogenesis	GO:0035107	397	0.017
macromolecular complex assembly	GO:0065003	256	0.017
exocrine system development	GO:0035272	162	0.017
photoreceptor cell fate commitment	GO:0046552	41	0.017
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.017
response to other organism	GO:0051707	293	0.017
eye photoreceptor cell development	GO:0042462	81	0.017
protein complex biogenesis	GO:0070271	201	0.016
anterior posterior pattern specification	GO:0009952	136	0.016
regulation of immune response	GO:0050776	118	0.016
regulation of cell shape	GO:0008360	113	0.016
multicellular organismal aging	GO:0010259	140	0.016
regulation of cellular amino acid metabolic process	GO:0006521	0	0.016
l amino acid import	GO:0043092	2	0.016
negative regulation of cellular biosynthetic process	GO:0031327	277	0.016
positive regulation of phosphate metabolic process	GO:0045937	139	0.016
amine metabolic process	GO:0009308	12	0.016
organic substance catabolic process	GO:1901575	308	0.016
embryonic morphogenesis	GO:0048598	206	0.016
positive regulation of response to stimulus	GO:0048584	323	0.016
body morphogenesis	GO:0010171	2	0.016
actin filament based process	GO:0030029	220	0.015
regulation of cellular component biogenesis	GO:0044087	201	0.015
cellular protein modification process	GO:0006464	438	0.015
tube morphogenesis	GO:0035239	191	0.015
aromatic compound catabolic process	GO:0019439	166	0.015
sensory perception of mechanical stimulus	GO:0050954	72	0.015
histone exchange	GO:0043486	21	0.015
regulation of phosphorus metabolic process	GO:0051174	210	0.015
death	GO:0016265	284	0.015
digestive system development	GO:0055123	149	0.015
cell growth	GO:0016049	108	0.015
anterior posterior axis specification embryo	GO:0008595	103	0.015
regulation of cellular ketone metabolic process	GO:0010565	3	0.015
rna processing	GO:0006396	147	0.015
regulation of neurogenesis	GO:0050767	158	0.015
regulation of organelle organization	GO:0033043	196	0.015
developmental growth	GO:0048589	280	0.015
positive regulation of cellular component organization	GO:0051130	156	0.014
cell death	GO:0008219	279	0.014
positive regulation of intracellular signal transduction	GO:1902533	116	0.014
response to organic substance	GO:0010033	284	0.014
sensory perception of chemical stimulus	GO:0007606	116	0.014
regulation of cytoskeleton organization	GO:0051493	89	0.014
lateral inhibition	GO:0046331	206	0.014
oocyte anterior posterior axis specification	GO:0007314	72	0.014
secretion by cell	GO:0032940	101	0.014
locomotory behavior	GO:0007626	176	0.014
nucleoside phosphate metabolic process	GO:0006753	162	0.014
positive regulation of cell motility	GO:2000147	3	0.014
regulation of cell differentiation	GO:0045595	302	0.014
positive regulation of transport	GO:0051050	92	0.014
anterior posterior axis specification	GO:0009948	109	0.014
salivary gland morphogenesis	GO:0007435	145	0.014
malpighian tubule development	GO:0072002	64	0.014
respiratory system development	GO:0060541	213	0.014
positive regulation of transcription dna templated	GO:0045893	266	0.014
tripartite regional subdivision	GO:0007351	103	0.014
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.014
defense response	GO:0006952	300	0.014
peripheral nervous system development	GO:0007422	52	0.013
membrane depolarization	GO:0051899	4	0.013
ras protein signal transduction	GO:0007265	88	0.013
response to lipopolysaccharide	GO:0032496	4	0.013
regulation of nervous system development	GO:0051960	248	0.013
regulation of gene expression epigenetic	GO:0040029	128	0.013
dorsal ventral axis specification	GO:0009950	66	0.013
associative learning	GO:0008306	65	0.013
signal transduction by phosphorylation	GO:0023014	107	0.013
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.013
secretion	GO:0046903	109	0.013
positive regulation of cellular biosynthetic process	GO:0031328	316	0.013
purine containing compound metabolic process	GO:0072521	155	0.013
small gtpase mediated signal transduction	GO:0007264	88	0.013
neurotransmitter transport	GO:0006836	37	0.013
gene silencing by rna	GO:0031047	57	0.013
response to abiotic stimulus	GO:0009628	341	0.013
salivary gland histolysis	GO:0035070	88	0.013
ribonucleotide metabolic process	GO:0009259	145	0.013
regulation of synapse organization	GO:0050807	110	0.012
rhythmic behavior	GO:0007622	76	0.012
autophagic cell death	GO:0048102	83	0.012
regulation of organ morphogenesis	GO:2000027	78	0.012
positive regulation of phosphorus metabolic process	GO:0010562	139	0.012
mitotic spindle organization	GO:0007052	220	0.012
telencephalon development	GO:0021537	2	0.012
protein catabolic process	GO:0030163	101	0.012
negative regulation of cellular component organization	GO:0051129	108	0.012
cation transmembrane transport	GO:0098655	88	0.012
chemotaxis	GO:0006935	249	0.012
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.012
heterocycle catabolic process	GO:0046700	166	0.012
organelle localization	GO:0051640	148	0.012
positive regulation of cellular protein metabolic process	GO:0032270	118	0.012
immune response regulating signaling pathway	GO:0002764	2	0.012
wnt signaling pathway	GO:0016055	98	0.012
oxoacid metabolic process	GO:0043436	103	0.012
protein transport	GO:0015031	155	0.012
phosphorylation	GO:0016310	294	0.012
regulation of cell morphogenesis	GO:0022604	163	0.012
regulation of excitatory postsynaptic membrane potential	GO:0060079	3	0.012
organic cyclic compound catabolic process	GO:1901361	168	0.012
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.012
nucleobase containing compound catabolic process	GO:0034655	165	0.011
digestive tract morphogenesis	GO:0048546	127	0.011
positive regulation of rna metabolic process	GO:0051254	271	0.011
regulation of synapse structure and activity	GO:0050803	128	0.011
regulation of neuron differentiation	GO:0045664	103	0.011
regulation of cell projection organization	GO:0031344	92	0.011
regulation of cellular protein metabolic process	GO:0032268	243	0.011
cell migration	GO:0016477	238	0.011
long term memory	GO:0007616	62	0.011
cholesterol homeostasis	GO:0042632	3	0.011
regulation of protein modification process	GO:0031399	112	0.011
hindgut morphogenesis	GO:0007442	58	0.011
detection of stimulus involved in sensory perception	GO:0050906	92	0.011
axon development	GO:0061564	297	0.011
cellular amine metabolic process	GO:0044106	12	0.011
positive regulation of cellular amine metabolic process	GO:0033240	0	0.011
regulation of cell substrate adhesion	GO:0010810	2	0.011
nucleotide metabolic process	GO:0009117	161	0.011
cellular macromolecule localization	GO:0070727	220	0.011
chaeta development	GO:0022416	97	0.011
extrinsic apoptotic signaling pathway	GO:0097191	1	0.011
response to wounding	GO:0009611	94	0.011
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.011
programmed cell death	GO:0012501	257	0.011
regulation of endocytosis	GO:0030100	37	0.011
spermatogenesis	GO:0007283	200	0.011
positive regulation of immune system process	GO:0002684	68	0.011
protein heterooligomerization	GO:0051291	4	0.011
posttranscriptional regulation of gene expression	GO:0010608	145	0.011
myotube cell development	GO:0014904	3	0.011
regulation of secretion	GO:0051046	44	0.011
response to bacterium	GO:0009617	198	0.011
notch signaling pathway	GO:0007219	120	0.011
positive regulation of molecular function	GO:0044093	136	0.011
regulation of neuron projection development	GO:0010975	69	0.011
positive regulation of rna biosynthetic process	GO:1902680	266	0.011
regulation of mitotic cell cycle	GO:0007346	190	0.011
mrna processing	GO:0006397	104	0.011
alternative mrna splicing via spliceosome	GO:0000380	60	0.011
embryonic development via the syncytial blastoderm	GO:0001700	148	0.011
establishment of nucleus localization	GO:0040023	26	0.011
defense response to bacterium	GO:0042742	178	0.011
determination of adult lifespan	GO:0008340	137	0.011
positive regulation of catalytic activity	GO:0043085	118	0.011
hindgut development	GO:0061525	58	0.011
mrna metabolic process	GO:0016071	124	0.011
regulation of phosphate metabolic process	GO:0019220	210	0.011
small molecule metabolic process	GO:0044281	305	0.011
regulation of protein localization	GO:0032880	76	0.011
positive regulation of cell migration	GO:0030335	2	0.011
negative regulation of rna metabolic process	GO:0051253	251	0.011
protein phosphorylation	GO:0006468	169	0.010
male meiosis	GO:0007140	52	0.010
cellular amino acid metabolic process	GO:0006520	61	0.010
immune response activating signal transduction	GO:0002757	2	0.010
nucleosome organization	GO:0034728	59	0.010
negative regulation of programmed cell death	GO:0043069	72	0.010
regulation of notch signaling pathway	GO:0008593	100	0.010
proteasomal protein catabolic process	GO:0010498	59	0.010
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.010
sensory perception	GO:0007600	196	0.010
tissue homeostasis	GO:0001894	36	0.010
positive regulation of protein metabolic process	GO:0051247	128	0.010
nitrogen compound transport	GO:0071705	85	0.010
multi organism behavior	GO:0051705	175	0.010
response to biotic stimulus	GO:0009607	294	0.010
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.010
nucleoside triphosphate catabolic process	GO:0009143	108	0.010
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.010
regulation of programmed cell death	GO:0043067	152	0.010
nephron development	GO:0072006	3	0.010

mfr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.041
	nervous system disease	DOID:863	0	0.018

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