IMP: Integrative Multi-species Prediction

Drosophila melanogaster

217 known processes

dco (Dmel_CG2048)

discs overgrown

(Aliases: l(3)discs overgrown-1,l(3)dco-1,0915/10,l(3)dco,l(3)discs overgrown,Dmel\CG2048,CKIepsilon,DCO,l(3)rK215,0538/13,CK1epsilon,DBT/CK1epsilon,DCO/CKIe,1396/02,dco-1,Dco/CK1,dCKIepsilon,l(3)S144701,Dco,1460/09,dbt,1447/01,l(3)S053813,ddbt,ck1epsilon,CG2048,DBT,l(3)j3B9,Dbt)

Entrez: 43673
FLYBASE: FBgn0002413
UniProtKB: O76324

Process Predictions
Disease Predictions

dco biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
circadian rhythm	GO:0007623	105	0.999
negative regulation of gene expression	GO:0010629	387	0.994
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.989
positive regulation of macromolecule metabolic process	GO:0010604	405	0.988
regionalization	GO:0003002	416	0.988
negative regulation of cellular biosynthetic process	GO:0031327	277	0.986
locomotory behavior	GO:0007626	176	0.985
epithelial cell differentiation	GO:0030855	322	0.982
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.980
post embryonic appendage morphogenesis	GO:0035120	385	0.977
negative regulation of transcription dna templated	GO:0045892	237	0.975
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.973
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.966
cellular protein modification process	GO:0006464	438	0.965
negative regulation of rna biosynthetic process	GO:1902679	240	0.962
rhythmic process	GO:0048511	106	0.950
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.950
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.948
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.948
immune system process	GO:0002376	347	0.944
negative regulation of cellular metabolic process	GO:0031324	382	0.941
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.940
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.939
positive regulation of gene expression	GO:0010628	290	0.930
negative regulation of rna metabolic process	GO:0051253	251	0.927
appendage development	GO:0048736	401	0.922
circadian behavior	GO:0048512	76	0.918
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.916
catabolic process	GO:0009056	409	0.915
negative regulation of response to stimulus	GO:0048585	258	0.909	Mouse Fly
transcription from rna polymerase ii promoter	GO:0006366	368	0.897
regulation of response to stress	GO:0080134	200	0.894
protein acetylation	GO:0006473	39	0.889
regulation of immune system process	GO:0002682	176	0.879
regulation of anatomical structure morphogenesis	GO:0022603	242	0.851
compound eye photoreceptor cell differentiation	GO:0001751	140	0.846
defense response	GO:0006952	300	0.837
positive regulation of transcription dna templated	GO:0045893	266	0.830
imaginal disc derived appendage development	GO:0048737	399	0.826
positive regulation of rna metabolic process	GO:0051254	271	0.813
negative regulation of signal transduction	GO:0009968	206	0.813	Mouse Fly
regulation of localization	GO:0032879	275	0.795
enteroendocrine cell differentiation	GO:0035883	1	0.764
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.762
negative regulation of cell communication	GO:0010648	223	0.758	Mouse Fly
photoreceptor cell differentiation	GO:0046530	170	0.752
regulation of intracellular signal transduction	GO:1902531	236	0.748
cellular catabolic process	GO:0044248	372	0.746
establishment of protein localization	GO:0045184	163	0.738
positive regulation of phosphate metabolic process	GO:0045937	139	0.732	Human
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.729
regulation of growth	GO:0040008	233	0.725
negative regulation of biosynthetic process	GO:0009890	277	0.722
developmental growth	GO:0048589	280	0.713
protein modification process	GO:0036211	438	0.709
eye photoreceptor cell differentiation	GO:0001754	145	0.705
tube development	GO:0035295	244	0.699
cellular protein catabolic process	GO:0044257	83	0.695
response to oxidative stress	GO:0006979	86	0.695
positive regulation of rna biosynthetic process	GO:1902680	266	0.688
organic substance catabolic process	GO:1901575	308	0.682
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.659
eye development	GO:0001654	323	0.659
muscle structure development	GO:0061061	224	0.651
cell migration	GO:0016477	238	0.645
cell proliferation	GO:0008283	299	0.644
regulation of organ morphogenesis	GO:2000027	78	0.643
neurological system process	GO:0050877	358	0.635
tissue morphogenesis	GO:0048729	297	0.626
biological adhesion	GO:0022610	138	0.619
compound eye development	GO:0048749	307	0.615
appendage morphogenesis	GO:0035107	397	0.608
aging	GO:0007568	143	0.608
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.601
protein localization to nucleus	GO:0034504	55	0.591
regulation of multicellular organismal development	GO:2000026	414	0.589
protein localization	GO:0008104	284	0.562	Yeast Mouse
modification dependent macromolecule catabolic process	GO:0043632	79	0.555
intracellular signal transduction	GO:0035556	300	0.544
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.539
regulation of cellular response to stress	GO:0080135	89	0.539
imaginal disc derived wing morphogenesis	GO:0007476	337	0.534
regulation of muscle organ development	GO:0048634	13	0.530
internal protein amino acid acetylation	GO:0006475	38	0.524
regulation of molecular function	GO:0065009	217	0.522
compound eye morphogenesis	GO:0001745	249	0.517
regulation of photoreceptor cell differentiation	GO:0046532	34	0.513
multi organism reproductive behavior	GO:0044705	121	0.507
modification dependent protein catabolic process	GO:0019941	78	0.504
cell motility	GO:0048870	251	0.504
multicellular organismal reproductive behavior	GO:0033057	110	0.504
ubiquitin dependent protein catabolic process	GO:0006511	78	0.499
positive regulation of cellular biosynthetic process	GO:0031328	316	0.492
regulation of organ growth	GO:0046620	42	0.484
dendrite development	GO:0016358	204	0.482
phosphorylation	GO:0016310	294	0.472
response to nutrient levels	GO:0031667	114	0.469
regulation of cellular protein metabolic process	GO:0032268	243	0.461
small molecule metabolic process	GO:0044281	305	0.459
regulation of response to external stimulus	GO:0032101	115	0.458
organelle assembly	GO:0070925	198	0.457	Human
regulation of protein modification process	GO:0031399	112	0.452	Human
multi organism behavior	GO:0051705	175	0.448	Fly
negative regulation of intracellular signal transduction	GO:1902532	57	0.447
multicellular organismal aging	GO:0010259	140	0.447
regulation of cellular localization	GO:0060341	136	0.435
rhythmic behavior	GO:0007622	76	0.434
morphogenesis of an epithelium	GO:0002009	276	0.433
regulation of developmental growth	GO:0048638	174	0.429	Worm
positive regulation of signal transduction	GO:0009967	223	0.428	Human Mouse
determination of adult lifespan	GO:0008340	137	0.428
regulation of cell cycle phase transition	GO:1901987	130	0.426
regulation of catabolic process	GO:0009894	170	0.425
chromosome organization	GO:0051276	360	0.424
regulation of phosphorus metabolic process	GO:0051174	210	0.420	Human
regulation of phosphate metabolic process	GO:0019220	210	0.407	Human
macromolecule catabolic process	GO:0009057	161	0.398
cardiovascular system development	GO:0072358	82	0.394
response to organic substance	GO:0010033	284	0.393
circadian regulation of gene expression	GO:0032922	5	0.389	Mouse
organophosphate metabolic process	GO:0019637	195	0.385
mrna metabolic process	GO:0016071	124	0.373
segmentation	GO:0035282	207	0.372
regulation of defense response	GO:0031347	102	0.366
reproductive behavior	GO:0019098	122	0.364
positive regulation of growth	GO:0045927	75	0.356
regulation of immune response	GO:0050776	118	0.355
internal peptidyl lysine acetylation	GO:0018393	38	0.353
localization of cell	GO:0051674	257	0.345
positive regulation of cell communication	GO:0010647	250	0.344	Human Mouse
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.342
dendrite morphogenesis	GO:0048813	199	0.340
regulation of neurogenesis	GO:0050767	158	0.334
adult behavior	GO:0030534	137	0.334
embryonic pattern specification	GO:0009880	174	0.334
regulation of cell proliferation	GO:0042127	163	0.333
cell adhesion	GO:0007155	136	0.331
eye photoreceptor cell fate commitment	GO:0042706	37	0.322
cell division	GO:0051301	248	0.319
peptidyl lysine acetylation	GO:0018394	39	0.317
compound eye photoreceptor fate commitment	GO:0001752	36	0.314
regulation of cellular catabolic process	GO:0031329	157	0.312
regulation of transport	GO:0051049	181	0.306
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.301
positive regulation of signaling	GO:0023056	243	0.299	Human Mouse
negative regulation of multicellular organismal process	GO:0051241	142	0.298
tor signaling	GO:0031929	32	0.298
cell fate specification	GO:0001708	71	0.296
positive regulation of phosphorus metabolic process	GO:0010562	139	0.291	Human
innate immune response	GO:0045087	144	0.288
cellular response to radiation	GO:0071478	52	0.285
regulation of apoptotic signaling pathway	GO:2001233	10	0.283
establishment of localization in cell	GO:0051649	402	0.280
immune system development	GO:0002520	57	0.278
cellular response to endogenous stimulus	GO:0071495	80	0.277
growth	GO:0040007	359	0.276
pole plasm assembly	GO:0007315	61	0.272
nucleotide metabolic process	GO:0009117	161	0.271
dna metabolic process	GO:0006259	227	0.270	Yeast Fly
regulation of pathway restricted smad protein phosphorylation	GO:0060393	1	0.269
organonitrogen compound metabolic process	GO:1901564	318	0.267
negative regulation of signaling	GO:0023057	219	0.257	Mouse Fly
oocyte differentiation	GO:0009994	145	0.251
carbohydrate derivative metabolic process	GO:1901135	217	0.251
regulation of cell death	GO:0010941	173	0.250
response to extracellular stimulus	GO:0009991	116	0.246
multicellular organismal homeostasis	GO:0048871	41	0.245
mitotic cell cycle phase transition	GO:0044772	138	0.243
protein localization to organelle	GO:0033365	82	0.242
response to organic cyclic compound	GO:0014070	89	0.236
multicellular organism growth	GO:0035264	46	0.236	Worm
head development	GO:0060322	135	0.234
mrna processing	GO:0006397	104	0.231
body morphogenesis	GO:0010171	2	0.230	Worm
lipid metabolic process	GO:0006629	121	0.229
mapk cascade	GO:0000165	107	0.225
single organism behavior	GO:0044708	391	0.223
wing disc morphogenesis	GO:0007472	344	0.223
regulation of protein metabolic process	GO:0051246	256	0.222
central nervous system development	GO:0007417	201	0.218
protein targeting to nucleus	GO:0044744	51	0.218
carbohydrate derivative biosynthetic process	GO:1901137	85	0.215
regulation of circadian rhythm	GO:0042752	49	0.213
muscle organ development	GO:0007517	127	0.212
homeostatic process	GO:0042592	199	0.211
regulation of neuron differentiation	GO:0045664	103	0.210
blastoderm segmentation	GO:0007350	159	0.206
cell death	GO:0008219	279	0.206
regulation of system process	GO:0044057	36	0.206
histone modification	GO:0016570	106	0.205
positive regulation of biosynthetic process	GO:0009891	316	0.204
response to starvation	GO:0042594	97	0.203
regulation of secretion by cell	GO:1903530	39	0.202
positive regulation of response to stimulus	GO:0048584	323	0.201	Human Mouse
response to endogenous stimulus	GO:0009719	119	0.200
covalent chromatin modification	GO:0016569	106	0.199
regulation of imaginal disc growth	GO:0045570	26	0.198
cellular response to abiotic stimulus	GO:0071214	58	0.198
protein import	GO:0017038	55	0.197
protein catabolic process	GO:0030163	101	0.193
connective tissue development	GO:0061448	3	0.192
negative regulation of growth	GO:0045926	84	0.191
negative regulation of defense response	GO:0031348	35	0.190
response to bacterium	GO:0009617	198	0.190
protein phosphorylation	GO:0006468	169	0.189
columnar cuboidal epithelial cell development	GO:0002066	249	0.189
autophagy	GO:0006914	108	0.184
negative regulation of cell death	GO:0060548	81	0.183
signal release	GO:0023061	49	0.183
signal transduction by phosphorylation	GO:0023014	107	0.182
regulation of cell differentiation	GO:0045595	302	0.182
regulation of mrna metabolic process	GO:1903311	72	0.177
imaginal disc derived leg morphogenesis	GO:0007480	80	0.177
protein import into nucleus	GO:0006606	51	0.176
actin cytoskeleton organization	GO:0030036	206	0.174
protein transport	GO:0015031	155	0.171
ras protein signal transduction	GO:0007265	88	0.166
single organism cell adhesion	GO:0098602	47	0.166
chromatin modification	GO:0016568	147	0.165
histone h4 acetylation	GO:0043967	13	0.164
reproductive structure development	GO:0048608	74	0.164
response to insulin	GO:0032868	29	0.163
regulation of cell fate commitment	GO:0010453	29	0.161
immune response	GO:0006955	246	0.161
purine ribonucleotide catabolic process	GO:0009154	109	0.160
negative regulation of cell proliferation	GO:0008285	69	0.158
establishment of protein localization to organelle	GO:0072594	62	0.157
organonitrogen compound catabolic process	GO:1901565	128	0.156
histone acetylation	GO:0016573	38	0.155
cellular response to hormone stimulus	GO:0032870	44	0.151
ribonucleoside metabolic process	GO:0009119	127	0.151
cellular response to organic substance	GO:0071310	132	0.149
proteasomal protein catabolic process	GO:0010498	59	0.149
epithelial cell development	GO:0002064	274	0.143
aromatic compound catabolic process	GO:0019439	166	0.142
muscle cell development	GO:0055001	50	0.141
positive regulation of canonical wnt signaling pathway	GO:0090263	7	0.140	Human Mouse
adult locomotory behavior	GO:0008344	76	0.138
regulation of striated muscle tissue development	GO:0016202	5	0.137
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.137
negative regulation of molecular function	GO:0044092	51	0.136
pole plasm mrna localization	GO:0019094	49	0.135
protein acylation	GO:0043543	42	0.134
circulatory system development	GO:0072359	82	0.134
nucleoside metabolic process	GO:0009116	127	0.133
regulation of protein transport	GO:0051223	57	0.133
notch signaling pathway	GO:0007219	120	0.128
response to other organism	GO:0051707	293	0.127
cellular response to insulin stimulus	GO:0032869	28	0.127
nuclear transport	GO:0051169	72	0.126
cellular response to dna damage stimulus	GO:0006974	223	0.124	Yeast Fly
regulation of nucleocytoplasmic transport	GO:0046822	35	0.123
positive regulation of intracellular signal transduction	GO:1902533	116	0.121
salivary gland morphogenesis	GO:0007435	145	0.120
cell cycle phase transition	GO:0044770	140	0.118
response to radiation	GO:0009314	155	0.117
muscle tissue development	GO:0060537	30	0.116
negative regulation of developmental growth	GO:0048640	64	0.116
actin filament based process	GO:0030029	220	0.116
imaginal disc growth	GO:0007446	37	0.116
gland development	GO:0048732	191	0.116
cellular response to chemical stimulus	GO:0070887	199	0.112
anterior posterior axis specification embryo	GO:0008595	103	0.111
response to abiotic stimulus	GO:0009628	341	0.111
nuclear import	GO:0051170	51	0.109
positive regulation of phosphorylation	GO:0042327	87	0.107	Human
secretion by cell	GO:0032940	101	0.105
oocyte axis specification	GO:0007309	108	0.105
regulation of behavior	GO:0050795	75	0.104
muscle cell differentiation	GO:0042692	103	0.104
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.104
positive regulation of developmental growth	GO:0048639	62	0.103	Worm
response to wounding	GO:0009611	94	0.103
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.101
response to biotic stimulus	GO:0009607	294	0.101
defense response to gram negative bacterium	GO:0050829	94	0.100
regulation of mitotic cell cycle	GO:0007346	190	0.099
nucleobase containing compound catabolic process	GO:0034655	165	0.099
carbohydrate metabolic process	GO:0005975	82	0.098
brain development	GO:0007420	120	0.098
regulation of protein phosphorylation	GO:0001932	64	0.098	Human
spermatogenesis	GO:0007283	200	0.098
myotube cell development	GO:0014904	3	0.096
immune response regulating signaling pathway	GO:0002764	2	0.096
oocyte development	GO:0048599	124	0.096
programmed cell death	GO:0012501	257	0.096
epithelial tube morphogenesis	GO:0060562	88	0.096
organic cyclic compound catabolic process	GO:1901361	168	0.095
single organism carbohydrate metabolic process	GO:0044723	72	0.095
response to organonitrogen compound	GO:0010243	75	0.094
anterior posterior axis specification	GO:0009948	109	0.093
organelle fission	GO:0048285	340	0.092	Yeast
single organism catabolic process	GO:0044712	228	0.092
jnk cascade	GO:0007254	50	0.092
cellular response to oxygen containing compound	GO:1901701	79	0.092
cell aging	GO:0007569	2	0.092
guanosine containing compound catabolic process	GO:1901069	74	0.091
positive regulation of pathway restricted smad protein phosphorylation	GO:0010862	1	0.090
cytoplasmic transport	GO:0016482	130	0.090	Yeast
stem cell division	GO:0017145	69	0.090
secretion	GO:0046903	109	0.089
positive regulation of mitotic cell cycle	GO:0045931	34	0.088
positive regulation of protein metabolic process	GO:0051247	128	0.088
cellular response to oxidative stress	GO:0034599	28	0.087
sister chromatid segregation	GO:0000819	92	0.087
tissue homeostasis	GO:0001894	36	0.086
negative regulation of immune system process	GO:0002683	50	0.085
guanosine containing compound metabolic process	GO:1901068	74	0.085
single organism nuclear import	GO:1902593	51	0.084
lateral inhibition	GO:0046331	206	0.083
olfactory behavior	GO:0042048	97	0.083
dephosphorylation	GO:0016311	51	0.082
intracellular transport	GO:0046907	228	0.082	Yeast
ribose phosphate metabolic process	GO:0019693	145	0.081
locomotor rhythm	GO:0045475	56	0.081
regulation of mrna processing	GO:0050684	71	0.079
response to oxygen containing compound	GO:1901700	200	0.079
positive regulation of mapk cascade	GO:0043410	63	0.079
axonogenesis	GO:0007409	290	0.079
positive regulation of cell proliferation	GO:0008284	47	0.078
negative regulation of cell cycle	GO:0045786	116	0.078
purine nucleoside catabolic process	GO:0006152	112	0.077
rna splicing via transesterification reactions	GO:0000375	73	0.077
purine ribonucleotide metabolic process	GO:0009150	145	0.076
compound eye photoreceptor development	GO:0042051	78	0.076
olfactory learning	GO:0008355	56	0.076
cellular macromolecule catabolic process	GO:0044265	136	0.076
rna splicing	GO:0008380	83	0.076
peptidyl lysine modification	GO:0018205	57	0.075
imaginal disc derived wing vein specification	GO:0007474	48	0.075
digestive system development	GO:0055123	149	0.074
axon development	GO:0061564	297	0.074
negative regulation of apoptotic process	GO:0043066	63	0.074
embryonic development via the syncytial blastoderm	GO:0001700	148	0.074
regulation of r7 cell differentiation	GO:0045676	15	0.073
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.073
regulation of jnk cascade	GO:0046328	40	0.073
ribonucleotide metabolic process	GO:0009259	145	0.072
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.072
protein dephosphorylation	GO:0006470	27	0.072
camera type eye development	GO:0043010	4	0.071
nucleoside catabolic process	GO:0009164	112	0.071
negative regulation of programmed cell death	GO:0043069	72	0.070
tripartite regional subdivision	GO:0007351	103	0.070
regulation of cellular response to insulin stimulus	GO:1900076	17	0.069
embryonic morphogenesis	GO:0048598	206	0.069
striated muscle cell differentiation	GO:0051146	90	0.069
regulation of cytoplasmic transport	GO:1903649	47	0.068
regulation of cell cycle	GO:0051726	291	0.067
regulation of stress activated mapk cascade	GO:0032872	41	0.067
regulation of innate immune response	GO:0045088	71	0.067
stress activated protein kinase signaling cascade	GO:0031098	55	0.067
photoreceptor cell fate commitment	GO:0046552	41	0.066
protein complex assembly	GO:0006461	200	0.066	Human
sex differentiation	GO:0007548	81	0.065
positive regulation of multicellular organismal process	GO:0051240	143	0.064	Worm
positive regulation of cellular protein metabolic process	GO:0032270	118	0.064
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.063
stress activated mapk cascade	GO:0051403	52	0.063
anatomical structure homeostasis	GO:0060249	97	0.063
tube morphogenesis	GO:0035239	191	0.063
cellular lipid metabolic process	GO:0044255	83	0.062
positive regulation of apoptotic process	GO:0043065	47	0.061
striated muscle cell development	GO:0055002	50	0.060
defense response to other organism	GO:0098542	225	0.060
anterior posterior pattern specification	GO:0009952	136	0.059
skeletal muscle organ development	GO:0060538	48	0.059
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.059
negative regulation of cell development	GO:0010721	62	0.059
cellular nitrogen compound catabolic process	GO:0044270	165	0.058
somatic stem cell division	GO:0048103	37	0.058
regulation of imaginal disc derived wing size	GO:0044719	20	0.058
apoptotic signaling pathway	GO:0097190	27	0.058
regulation of anatomical structure size	GO:0090066	163	0.058
oocyte construction	GO:0007308	112	0.057
negative regulation of cell differentiation	GO:0045596	143	0.057
carbohydrate derivative catabolic process	GO:1901136	118	0.056
small gtpase mediated signal transduction	GO:0007264	88	0.056
intracellular protein transport	GO:0006886	104	0.056
cellular protein localization	GO:0034613	160	0.056	Yeast Mouse
cellular response to lipid	GO:0071396	20	0.055
negative regulation of catalytic activity	GO:0043086	42	0.055
striated muscle tissue development	GO:0014706	27	0.054
nucleoside triphosphate metabolic process	GO:0009141	120	0.054
response to transforming growth factor beta	GO:0071559	18	0.054
cellular metal ion homeostasis	GO:0006875	31	0.053
cellular response to organonitrogen compound	GO:0071417	36	0.053
nucleoside triphosphate catabolic process	GO:0009143	108	0.053
nucleoside phosphate metabolic process	GO:0006753	162	0.053
regulation of protein catabolic process	GO:0042176	55	0.053
nucleobase containing small molecule metabolic process	GO:0055086	174	0.053
oviposition	GO:0018991	19	0.053
glycosyl compound metabolic process	GO:1901657	127	0.053
regulation of transferase activity	GO:0051338	58	0.052
protein targeting	GO:0006605	64	0.052
cell type specific apoptotic process	GO:0097285	38	0.052
metal ion transport	GO:0030001	74	0.052
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.052
metal ion homeostasis	GO:0055065	44	0.052
phagocytosis	GO:0006909	215	0.051	Fly
regulation of actin filament based process	GO:0032970	42	0.051
regulation of notch signaling pathway	GO:0008593	100	0.051
positive regulation of cell differentiation	GO:0045597	64	0.051
purine nucleoside metabolic process	GO:0042278	127	0.050
apoptotic process	GO:0006915	159	0.050
cellular homeostasis	GO:0019725	80	0.050
hematopoietic or lymphoid organ development	GO:0048534	57	0.049
photoreceptor cell development	GO:0042461	96	0.049
mrna splicing via spliceosome	GO:0000398	73	0.049
regulation of phosphorylation	GO:0042325	147	0.049	Human
carboxylic acid metabolic process	GO:0019752	92	0.048
meiosis i	GO:0007127	59	0.048	Yeast
chromatin organization	GO:0006325	207	0.048
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.047
somatic muscle development	GO:0007525	66	0.047
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.047
cell fate determination	GO:0001709	91	0.047
ion transport	GO:0006811	145	0.047
terminal region determination	GO:0007362	25	0.047
epidermal cell differentiation	GO:0009913	51	0.046
myofibril assembly	GO:0030239	36	0.046
inter male aggressive behavior	GO:0002121	60	0.046	Fly
male gamete generation	GO:0048232	201	0.046
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.046
regulation of catalytic activity	GO:0050790	185	0.045
muscle fiber development	GO:0048747	12	0.045
cell maturation	GO:0048469	144	0.045
negative regulation of apoptotic signaling pathway	GO:2001234	5	0.045
blood circulation	GO:0008015	26	0.045
cellular macromolecule localization	GO:0070727	220	0.045	Yeast Mouse
eye morphogenesis	GO:0048592	260	0.044
immune response activating signal transduction	GO:0002757	2	0.043
regulation of cell development	GO:0060284	215	0.042
r7 cell differentiation	GO:0045466	43	0.042
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.042
regulation of mapk cascade	GO:0043408	92	0.042
negative regulation of protein metabolic process	GO:0051248	85	0.042
actomyosin structure organization	GO:0031032	56	0.042
glycosyl compound catabolic process	GO:1901658	112	0.042
heterocycle catabolic process	GO:0046700	166	0.041
organonitrogen compound biosynthetic process	GO:1901566	117	0.041
organ growth	GO:0035265	56	0.041
axon guidance	GO:0007411	233	0.041
positive regulation of intracellular protein transport	GO:0090316	30	0.041
mesenchymal cell development	GO:0014031	1	0.041
regulation of cellular ketone metabolic process	GO:0010565	3	0.040
regulation of tor signaling	GO:0032006	21	0.040
mitotic nuclear division	GO:0007067	213	0.040	Yeast
regulation of programmed cell death	GO:0043067	152	0.039
defense response to bacterium	GO:0042742	178	0.039
regulation of cell morphogenesis	GO:0022604	163	0.039
macromolecule deacylation	GO:0098732	11	0.039
cell fate commitment involved in pattern specification	GO:0060581	31	0.038
detection of stimulus	GO:0051606	156	0.038
peptide metabolic process	GO:0006518	80	0.037
gtp catabolic process	GO:0006184	72	0.036
positive regulation of cellular catabolic process	GO:0031331	95	0.036
glycoprotein metabolic process	GO:0009100	41	0.035
negative regulation of phosphorylation	GO:0042326	35	0.035
gland morphogenesis	GO:0022612	145	0.035
digestive tract development	GO:0048565	149	0.035
pole plasm rna localization	GO:0007316	52	0.035
actin filament organization	GO:0007015	126	0.035
cellular response to peptide hormone stimulus	GO:0071375	28	0.035
negative regulation of imaginal disc growth	GO:0045571	8	0.035
morphogenesis of a branching epithelium	GO:0061138	45	0.034
response to external biotic stimulus	GO:0043207	293	0.033
sarcomere organization	GO:0045214	26	0.033
positive regulation of transport	GO:0051050	92	0.033
purine containing compound catabolic process	GO:0072523	112	0.033
imaginal disc derived leg segmentation	GO:0036011	26	0.033
heart development	GO:0007507	82	0.033
positive regulation of catabolic process	GO:0009896	105	0.033
cell activation	GO:0001775	9	0.033
negative regulation of phosphate metabolic process	GO:0045936	45	0.033
response to hormone	GO:0009725	45	0.033
ribonucleoside catabolic process	GO:0042454	112	0.032
regulation of protein kinase activity	GO:0045859	51	0.032
macromolecular complex assembly	GO:0065003	256	0.032	Human
negative regulation of developmental process	GO:0051093	201	0.032
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.031
regulation of multicellular organism growth	GO:0040014	40	0.031	Worm
regulation of protein localization to nucleus	GO:1900180	29	0.031
rna processing	GO:0006396	147	0.031	Yeast
regulation of epithelial cell differentiation	GO:0030856	4	0.031
peptidyl amino acid modification	GO:0018193	105	0.031
positive regulation of molecular function	GO:0044093	136	0.030
morphogenesis of follicular epithelium	GO:0016333	36	0.030
response to light stimulus	GO:0009416	124	0.030
branching morphogenesis of an epithelial tube	GO:0048754	45	0.030
eye antennal disc development	GO:0035214	60	0.030
reproductive system development	GO:0061458	74	0.030
purine containing compound metabolic process	GO:0072521	155	0.030
regulation of ras protein signal transduction	GO:0046578	93	0.030
histone deacetylation	GO:0016575	9	0.030
sensory organ morphogenesis	GO:0090596	260	0.029
regulation of cell substrate adhesion	GO:0010810	2	0.029
organic acid metabolic process	GO:0006082	103	0.029

dco disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.081

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