Drosophila melanogaster

122 known processes

lgs (Dmel_CG2041)

legless

(Aliases: Dmel\CG2041,CG2041,BCL9,Lgl,Lgs)

lgs biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
embryonic development via the syncytial blastodermGO:00017001480.630
regulation of gtp catabolic processGO:0033124440.605
single organism behaviorGO:00447083910.599
regulation of small gtpase mediated signal transductionGO:0051056930.586
regulation of transcription from rna polymerase ii promoterGO:00063573780.550
intracellular signal transductionGO:00355563000.476
regulation of ras protein signal transductionGO:0046578930.472
protein modification processGO:00362114380.462
developmental growthGO:00485892800.429
embryonic morphogenesisGO:00485982060.413
negative regulation of signalingGO:00230572190.404
regulation of molecular functionGO:00650092170.400
guanosine containing compound metabolic processGO:1901068740.385
guanosine containing compound catabolic processGO:1901069740.354
nucleobase containing compound catabolic processGO:00346551650.347
negative regulation of cell communicationGO:00106482230.314
transcription from rna polymerase ii promoterGO:00063663680.303
cellular response to fibroblast growth factor stimulusGO:0044344100.287
positive regulation of gtpase activityGO:0043547430.286
cellular response to dna damage stimulusGO:00069742230.280
establishment of localization in cellGO:00516494020.268
catabolic processGO:00090564090.255
ras protein signal transductionGO:0007265880.250
regulation of gtpase activityGO:0043087440.249
ion transmembrane transportGO:00342201220.247
cellular response to abiotic stimulusGO:0071214580.246
deathGO:00162652840.245
positive regulation of ras gtpase activityGO:0032320360.239
regulation of cell cycle phase transitionGO:19019871300.238
imaginal disc derived leg morphogenesisGO:0007480800.237
negative regulation of signal transductionGO:00099682060.237
embryonic pattern specificationGO:00098801740.228
heart developmentGO:0007507820.227
positive regulation of rna metabolic processGO:00512542710.223
regulation of intracellular signal transductionGO:19025312360.222
regulation of endopeptidase activityGO:0052548360.208
regulation of phosphorus metabolic processGO:00511742100.206
positive regulation of catabolic processGO:00098961050.205
digestive system developmentGO:00551231490.198
cellular catabolic processGO:00442483720.195
cellular protein localizationGO:00346131600.193
positive regulation of gtp catabolic processGO:0033126430.190
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.188
positive regulation of transcription dna templatedGO:00458932660.179
embryo development ending in birth or egg hatchingGO:00097921520.176
regulation of ras gtpase activityGO:0032318380.173
heterocycle catabolic processGO:00467001660.169
tube morphogenesisGO:00352391910.168
wnt signaling pathwayGO:0016055980.164
dendrite morphogenesisGO:00488131990.164
nucleocytoplasmic transportGO:0006913720.159
negative regulation of cellular protein metabolic processGO:0032269850.158
small gtpase mediated signal transductionGO:0007264880.155
protein localizationGO:00081042840.151
positive regulation of phosphate metabolic processGO:00459371390.150
epithelial cell differentiationGO:00308553220.150
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.148
regulation of cellular protein catabolic processGO:1903362440.144
regulation of cellular protein metabolic processGO:00322682430.143
gtp metabolic processGO:0046039720.139
phosphorylationGO:00163102940.137
regulation of protein import into nucleusGO:0042306280.133
regulation of stress activated protein kinase signaling cascadeGO:0070302420.128
cellular macromolecule catabolic processGO:00442651360.127
single organism nuclear importGO:1902593510.127
organic substance catabolic processGO:19015753080.125
regulation of catabolic processGO:00098941700.119
cellular response to radiationGO:0071478520.118
larval lymph gland hemocyte differentiationGO:0035168110.116
regulation of cellular catabolic processGO:00313291570.116
segmentationGO:00352822070.113
tissue morphogenesisGO:00487292970.111
regulation of catalytic activityGO:00507901850.111
intracellular transportGO:00469072280.110
small molecule metabolic processGO:00442813050.109
positive regulation of catalytic activityGO:00430851180.109
retina development in camera type eyeGO:006004140.109
tube developmentGO:00352952440.106
vesicle mediated transportGO:00161923810.104
digestive tract developmentGO:00485651490.103
organonitrogen compound metabolic processGO:19015643180.102
localization of cellGO:00516742570.102
synapse assemblyGO:00074161430.099
positive regulation of nucleic acid templated transcriptionGO:19035082660.098
cytoplasmic transportGO:00164821300.098
adult behaviorGO:00305341370.097
neurological system processGO:00508773580.097
cellular protein modification processGO:00064644380.097
ribonucleoside triphosphate catabolic processGO:00092031080.095
positive regulation of cellular biosynthetic processGO:00313283160.089
positive regulation of molecular functionGO:00440931360.088
organic cyclic compound catabolic processGO:19013611680.088
protein transportGO:00150311550.087
anatomical structure homeostasisGO:0060249970.086
regulation of hydrolase activityGO:0051336970.086
response to abiotic stimulusGO:00096283410.086
establishment of protein localizationGO:00451841630.084
cellular macromolecule localizationGO:00707272200.084
positive regulation of nucleobase containing compound metabolic processGO:00459353320.083
endocytosisGO:00068973100.081
circulatory system developmentGO:0072359820.080
purine ribonucleotide catabolic processGO:00091541090.080
sensory perceptionGO:00076001960.080
eye developmentGO:00016543230.078
positive regulation of jun kinase activityGO:004350740.077
cardiovascular system developmentGO:0072358820.076
fibroblast growth factor receptor signaling pathwayGO:0008543100.075
stem cell developmentGO:0048864790.073
negative regulation of protein metabolic processGO:0051248850.073
positive regulation of rna biosynthetic processGO:19026802660.073
regulation of purine nucleotide catabolic processGO:0033121480.072
regulation of intracellular protein transportGO:0033157460.071
regulation of wnt signaling pathwayGO:0030111680.071
phagocytosisGO:00069092150.071
regulation of protein metabolic processGO:00512462560.071
protein phosphorylationGO:00064681690.070
regulation of synapse structure and activityGO:00508031280.070
macromolecule catabolic processGO:00090571610.067
signal transduction by phosphorylationGO:00230141070.067
negative regulation of response to stimulusGO:00485852580.065
negative regulation of proteolysisGO:0045861310.065
ribonucleoside triphosphate metabolic processGO:00091991190.063
gtp catabolic processGO:0006184720.063
positive regulation of phosphorus metabolic processGO:00105621390.062
eye morphogenesisGO:00485922600.061
single organism intracellular transportGO:19025822070.061
regulation of phosphate metabolic processGO:00192202100.060
dendrite developmentGO:00163582040.060
regulation of erk1 and erk2 cascadeGO:0070372390.059
purine nucleoside catabolic processGO:00061521120.057
response to fibroblast growth factorGO:0071774100.057
post embryonic appendage morphogenesisGO:00351203850.057
positive regulation of developmental growthGO:0048639620.056
mapk cascadeGO:00001651070.056
negative regulation of molecular functionGO:0044092510.055
rubidium ion transportGO:003582610.055
intracellular protein transportGO:00068861040.054
negative regulation of gene expressionGO:00106293870.053
regulation of cytoplasmic transportGO:1903649470.053
protein targeting to nucleusGO:0044744510.052
regulation of proteolysisGO:0030162870.051
regulation of nucleocytoplasmic transportGO:0046822350.051
axonogenesisGO:00074092900.051
regulation of nucleoside metabolic processGO:0009118500.051
gland developmentGO:00487321910.051
positive regulation of nitrogen compound metabolic processGO:00511733540.050
nucleoside triphosphate metabolic processGO:00091411200.050
regulation of protein localizationGO:0032880760.049
programmed cell deathGO:00125012570.049
purine nucleoside triphosphate catabolic processGO:00091461080.049
nucleoside triphosphate catabolic processGO:00091431080.049
positive regulation of cellular catabolic processGO:0031331950.048
purine ribonucleoside catabolic processGO:00461301120.048
regulation of protein modification processGO:00313991120.048
protein maturationGO:0051604710.048
glycosyl compound catabolic processGO:19016581120.048
protein modification by small protein conjugation or removalGO:00706471060.047
protein ubiquitinationGO:0016567700.047
single organism cellular localizationGO:19025801800.046
negative regulation of wnt signaling pathwayGO:0030178280.046
negative regulation of cellular metabolic processGO:00313243820.046
morphogenesis of an epitheliumGO:00020092760.046
regulation of multicellular organismal developmentGO:20000264140.044
ectodermal placode formationGO:006078840.044
ribonucleoside catabolic processGO:00424541120.043
response to external biotic stimulusGO:00432072930.043
regulation of rab gtpase activityGO:003231370.043
regulation of nervous system developmentGO:00519602480.043
immune system developmentGO:0002520570.043
carbohydrate derivative metabolic processGO:19011352170.043
gene silencing by rnaGO:0031047570.042
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434370.042
regulation of intracellular transportGO:0032386640.041
regulation of mapk cascadeGO:0043408920.041
positive regulation of nucleoside metabolic processGO:0045979470.040
cellular nitrogen compound catabolic processGO:00442701650.040
mitotic nuclear divisionGO:00070672130.039
nucleoside catabolic processGO:00091641120.039
regulation of programmed cell deathGO:00430671520.038
organelle localizationGO:00516401480.037
appendage developmentGO:00487364010.037
developmental growth involved in morphogenesisGO:0060560650.036
regulation of nucleotide catabolic processGO:0030811480.036
regulation of neuron differentiationGO:00456641030.036
cell cycle phase transitionGO:00447701400.035
homeostatic processGO:00425921990.035
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052240.035
purine nucleoside metabolic processGO:00422781270.035
regulation of g1 s transition of mitotic cell cycleGO:2000045230.034
regulation of localizationGO:00328792750.034
positive regulation of intracellular signal transductionGO:19025331160.034
positive regulation of macromolecule biosynthetic processGO:00105572830.034
appendage morphogenesisGO:00351073970.033
organic substance transportGO:00717022570.033
smoothened signaling pathwayGO:0007224490.033
periodic partitioningGO:0007365290.033
mesoderm developmentGO:0007498780.032
ribonucleotide catabolic processGO:00092611090.032
meiosis iGO:0007127590.032
protein import into nucleusGO:0006606510.032
morphogenesis of embryonic epitheliumGO:0016331940.031
purine ribonucleoside metabolic processGO:00461281270.031
negative regulation of phosphorylationGO:0042326350.031
negative regulation of protein processingGO:0010955310.030
central nervous system developmentGO:00074172010.030
forebrain developmentGO:003090020.029
positive regulation of transportGO:0051050920.029
nuclear transportGO:0051169720.028
cell cycle g1 s phase transitionGO:0044843310.028
spindle assemblyGO:0051225800.028
mitotic spindle organizationGO:00070522200.028
mitotic dna damage checkpointGO:0044773740.027
regulation of stress activated mapk cascadeGO:0032872410.027
reproductive system developmentGO:0061458740.027
response to endogenous stimulusGO:00097191190.027
head developmentGO:00603221350.027
organelle assemblyGO:00709251980.027
regulation of stem cell proliferationGO:0072091400.027
purine nucleoside triphosphate metabolic processGO:00091441190.026
response to growth factorGO:0070848310.026
enzyme linked receptor protein signaling pathwayGO:00071671790.026
regulation of developmental growthGO:00486381740.026
axon developmentGO:00615642970.025
regulation of protein localization to nucleusGO:1900180290.025
regulation of growthGO:00400082330.025
response to radiationGO:00093141550.025
regulation of organelle organizationGO:00330431960.025
camera type eye developmentGO:004301040.025
proteolysisGO:00065081920.024
epithelial cell developmentGO:00020642740.024
regulation of jnk cascadeGO:0046328400.023
regulation of establishment of protein localizationGO:0070201610.023
spindle organizationGO:00070512530.023
positive regulation of proteolysisGO:0045862520.022
protein processingGO:0016485680.022
positive regulation of purine nucleotide catabolic processGO:0033123460.022
negative regulation of nucleic acid templated transcriptionGO:19035072400.022
positive regulation of nucleotide catabolic processGO:0030813460.021
reproductive structure developmentGO:0048608740.021
spermatogenesisGO:00072832000.021
positive regulation of response to stimulusGO:00485843230.021
sensory organ morphogenesisGO:00905962600.021
ectodermal placode developmentGO:007169640.020
ubiquitin dependent protein catabolic processGO:0006511780.020
positive regulation of signalingGO:00230562430.020
camera type eye morphogenesisGO:004859320.020
neuromuscular junction developmentGO:00075281490.020
columnar cuboidal epithelial cell differentiationGO:00020652560.020
stress activated mapk cascadeGO:0051403520.020
regulation of proteasomal protein catabolic processGO:0061136390.020
protein complex biogenesisGO:00702712010.020
collateral sproutingGO:004866830.020
convergent extension involved in gastrulationGO:006002720.020
negative regulation of intracellular signal transductionGO:1902532570.019
positive regulation of signal transductionGO:00099672230.019
single organism catabolic processGO:00447122280.019
axon guidanceGO:00074112330.019
organic acid metabolic processGO:00060821030.019
response to organic substanceGO:00100332840.019
negative regulation of cellular component organizationGO:00511291080.018
regulation of mitotic cell cycle phase transitionGO:19019901300.018
regulation of cell cycleGO:00517262910.018
nucleobase containing small molecule metabolic processGO:00550861740.018
protein targetingGO:0006605640.018
positive regulation of rab gtpase activityGO:003285170.018
positive regulation of cell communicationGO:00106472500.018
connective tissue developmentGO:006144830.018
cellular protein catabolic processGO:0044257830.018
peptidyl amino acid modificationGO:00181931050.018
cellular response to growth factor stimulusGO:0071363300.018
regulation of hemocyte proliferationGO:0035206370.018
regulation of transportGO:00510491810.017
establishment or maintenance of cell polarityGO:00071631670.017
purine ribonucleoside triphosphate metabolic processGO:00092051190.017
glycosyl compound metabolic processGO:19016571270.017
learning or memoryGO:00076111410.017
protein importGO:0017038550.017
cellular response to endogenous stimulusGO:0071495800.017
positive regulation of macromolecule metabolic processGO:00106044050.017
modification dependent macromolecule catabolic processGO:0043632790.017
protein modification by small protein conjugationGO:0032446790.016
nucleoside metabolic processGO:00091161270.016
negative regulation of cell cycle phase transitionGO:19019881030.016
regulation of cell cycle processGO:00105641810.016
regulation of phosphorylationGO:00423251470.016
establishment of vesicle localizationGO:0051650510.016
segment polarity determinationGO:0007367250.016
development of primary sexual characteristicsGO:0045137500.016
gastrulationGO:0007369700.016
positive regulation of biosynthetic processGO:00098913160.016
dorsal closureGO:0007391790.015
nucleoside phosphate metabolic processGO:00067531620.015
positive regulation of purine nucleotide metabolic processGO:1900544550.015
eye antennal disc developmentGO:0035214600.015
synapse organizationGO:00508081960.015
telencephalon developmentGO:002153720.015
regulation of cellular component biogenesisGO:00440872010.015
purine containing compound catabolic processGO:00725231120.015
protein localization to nucleusGO:0034504550.015
multicellular organism growthGO:0035264460.015
proteolysis involved in cellular protein catabolic processGO:0051603830.015
establishment of organelle localizationGO:00516561220.015
neural retina developmentGO:000340740.015
regulation of cell cycle g1 s phase transitionGO:1902806230.015
nucleotide metabolic processGO:00091171610.015
mesenchymal cell differentiationGO:004876210.015
erk1 and erk2 cascadeGO:0070371390.014
carbohydrate derivative catabolic processGO:19011361180.014
ribose phosphate metabolic processGO:00196931450.014
positive regulation of mapk cascadeGO:0043410630.014
sensory perception of soundGO:0007605560.014
negative regulation of chromosome organizationGO:2001251190.014
imaginal disc growthGO:0007446370.014
growthGO:00400073590.014
regulation of cellular response to stressGO:0080135890.014
mitotic dna integrity checkpointGO:0044774750.014
regulation of transmembrane transporter activityGO:002289860.014
cell deathGO:00082192790.014
negative regulation of proteolysis involved in cellular protein catabolic processGO:1903051170.014
regulation of viral genome replicationGO:004506940.014
positive regulation of protein metabolic processGO:00512471280.014
positive regulation of cell developmentGO:0010720610.013
positive regulation of stem cell differentiationGO:200073830.013
hematopoietic or lymphoid organ developmentGO:0048534570.013
regulation of purine nucleotide metabolic processGO:1900542620.013
nucleoside phosphate catabolic processGO:19012921100.013
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.013
dna templated transcription elongationGO:0006354180.013
regulation of response to external stimulusGO:00321011150.013
nuclear importGO:0051170510.013
stem cell proliferationGO:0072089880.013
nuclear divisionGO:00002803320.013
regulation of protein targetingGO:1903533290.013
sister chromatid segregationGO:0000819920.012
regulation of epithelial cell proliferationGO:005067840.012
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.012
leg disc morphogenesisGO:0007478800.012
bmp signaling pathwayGO:0030509270.012
mesenchymal cell developmentGO:001403110.012
agingGO:00075681430.012
regulation of cell developmentGO:00602842150.012
post embryonic hemopoiesisGO:0035166170.012
photoreceptor cell differentiationGO:00465301700.012
stem cell differentiationGO:00488631170.012
aromatic compound catabolic processGO:00194391660.012
hindbrain developmentGO:003090220.012
embryonic organ developmentGO:0048568500.012
dephosphorylationGO:0016311510.011
dna methylation or demethylationGO:004472840.011
limb developmentGO:006017310.011
histone h3 k27 methylationGO:007073460.011
spinal cord developmentGO:002151010.011
meiotic cell cycleGO:00513211710.011
mitotic cell cycle phase transitionGO:00447721380.011
neural precursor cell proliferationGO:0061351750.011
mushroom body developmentGO:0016319700.011
positive regulation of hydrolase activityGO:0051345780.011
sensory perception of mechanical stimulusGO:0050954720.011
cellular response to light stimulusGO:0071482370.011
regulation of striated muscle contractionGO:000694220.011
male gamete generationGO:00482322010.011
negative regulation of cell deathGO:0060548810.011
instar larval developmentGO:0002168550.011
hemopoiesisGO:0030097460.010
nephron tubule morphogenesisGO:007207830.010
mitotic cell cycle checkpointGO:0007093880.010
negative regulation of rna metabolic processGO:00512532510.010
meiotic cell cycle processGO:19030461320.010
negative regulation of smoothened signaling pathwayGO:0045879160.010
adult locomotory behaviorGO:0008344760.010
ribonucleotide metabolic processGO:00092591450.010
response to light stimulusGO:00094161240.010

lgs disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.022
disease of anatomical entityDOID:700.019
cancerDOID:16200.015
organ system cancerDOID:005068600.015