IMP: Integrative Multi-species Prediction

Drosophila melanogaster

96 known processes

Tip60 (Dmel_CG6121)

CG6121 gene product from transcript CG6121-RA

(Aliases: CG6121,EG:EG0007.7,dmHAG405,Dmel\TIP60,Dmel\CG6121,dTip60,Dmel/TIP60,6121,EG0007.7,dTIP60,DmEG0007.7)

FLYBASE: FBgn0026080
Entrez: 31362
UniProtKB: M9PGN1
UniProtKB: Q960X4
UniProtKB: M9PH08

Process Predictions
Disease Predictions

Tip60 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of cellular metabolic process	GO:0031324	382	0.947
negative regulation of cellular biosynthetic process	GO:0031327	277	0.895
negative regulation of transcription dna templated	GO:0045892	237	0.833
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.717
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.713
positive regulation of developmental growth	GO:0048639	62	0.663
cytoskeleton dependent cytokinesis	GO:0061640	81	0.642
negative regulation of rna biosynthetic process	GO:1902679	240	0.519
cytokinesis	GO:0000910	90	0.515
negative regulation of rna metabolic process	GO:0051253	251	0.444
dna integrity checkpoint	GO:0031570	81	0.441	Fly
mitotic cell cycle checkpoint	GO:0007093	88	0.439
negative regulation of response to stimulus	GO:0048585	258	0.437
regulation of developmental growth	GO:0048638	174	0.430
transcription from rna polymerase ii promoter	GO:0006366	368	0.382	Mouse Rat
growth	GO:0040007	359	0.364
negative regulation of cellular component organization	GO:0051129	108	0.360
developmental growth	GO:0048589	280	0.351
regulation of cell cycle	GO:0051726	291	0.347
protein modification process	GO:0036211	438	0.340
protein localization to organelle	GO:0033365	82	0.338	Worm
negative regulation of gene expression	GO:0010629	387	0.336
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.329
cellular macromolecule catabolic process	GO:0044265	136	0.308
regulation of cell cycle process	GO:0010564	181	0.306
meiotic cytokinesis	GO:0033206	33	0.304
positive regulation of developmental process	GO:0051094	143	0.300
cellular protein localization	GO:0034613	160	0.296	Worm
mitotic g2 m transition checkpoint	GO:0044818	70	0.292
positive regulation of cell communication	GO:0010647	250	0.281
regulation of mitotic cell cycle	GO:0007346	190	0.279
cell death	GO:0008219	279	0.276
regulation of anatomical structure morphogenesis	GO:0022603	242	0.276
cellular protein modification process	GO:0006464	438	0.275
multi organism behavior	GO:0051705	175	0.274
catabolic process	GO:0009056	409	0.274
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.269
dendrite development	GO:0016358	204	0.264
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.261
positive regulation of multicellular organism growth	GO:0040018	21	0.258
modification dependent protein catabolic process	GO:0019941	78	0.257
meiotic nuclear division	GO:0007126	151	0.251
mitotic cell cycle phase transition	GO:0044772	138	0.250
positive regulation of response to stimulus	GO:0048584	323	0.234
establishment or maintenance of cell polarity	GO:0007163	167	0.230
meiotic cell cycle	GO:0051321	171	0.230
organelle fission	GO:0048285	340	0.218
organic substance catabolic process	GO:1901575	308	0.210
modification dependent macromolecule catabolic process	GO:0043632	79	0.208
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.203
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.200	Mouse Rat
g2 dna damage checkpoint	GO:0031572	69	0.194
positive regulation of multicellular organismal process	GO:0051240	143	0.192
dna damage checkpoint	GO:0000077	78	0.188	Fly
positive regulation of rna biosynthetic process	GO:1902680	266	0.187	Mouse Rat
mitotic g2 dna damage checkpoint	GO:0007095	69	0.183
negative regulation of protein tyrosine kinase activity	GO:0061099	5	0.181
protein localization	GO:0008104	284	0.180	Worm
regionalization	GO:0003002	416	0.177
negative regulation of cell cycle process	GO:0010948	109	0.175
positive regulation of transcription dna templated	GO:0045893	266	0.170	Mouse Rat
regulation of localization	GO:0032879	275	0.166
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.164	Mouse Rat
proteolysis	GO:0006508	192	0.162
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.158
organelle assembly	GO:0070925	198	0.158
cellular catabolic process	GO:0044248	372	0.156
embryo development ending in birth or egg hatching	GO:0009792	152	0.156	Worm
regulation of cell cycle phase transition	GO:1901987	130	0.146
negative regulation of cell cycle	GO:0045786	116	0.145
proteasomal protein catabolic process	GO:0010498	59	0.140
axis specification	GO:0009798	167	0.134
chromosome organization	GO:0051276	360	0.131
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.131	Mouse Rat
histone modification	GO:0016570	106	0.129
nuclear division	GO:0000280	332	0.126
regulation of erbb signaling pathway	GO:1901184	42	0.122
positive regulation of growth	GO:0045927	75	0.122
organic substance transport	GO:0071702	257	0.122
regulation of multicellular organismal development	GO:2000026	414	0.119	Worm
mitotic cytokinesis	GO:0000281	50	0.117
cellular protein catabolic process	GO:0044257	83	0.116
phosphorylation	GO:0016310	294	0.114
response to organic substance	GO:0010033	284	0.114
cell cycle phase transition	GO:0044770	140	0.113
multi organism reproductive behavior	GO:0044705	121	0.111
negative regulation of nervous system development	GO:0051961	92	0.107
peptidyl amino acid modification	GO:0018193	105	0.106
negative regulation of signaling	GO:0023057	219	0.103
positive regulation of cellular biosynthetic process	GO:0031328	316	0.101	Mouse Rat
mitotic dna integrity checkpoint	GO:0044774	75	0.097
macromolecular complex assembly	GO:0065003	256	0.095
macromolecule catabolic process	GO:0009057	161	0.093
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.093
regulation of protein deacetylation	GO:0090311	2	0.093
regulation of programmed cell death	GO:0043067	152	0.087
single organism behavior	GO:0044708	391	0.087
ubiquitin dependent protein catabolic process	GO:0006511	78	0.085
multicellular organismal aging	GO:0010259	140	0.085
cellular macromolecule localization	GO:0070727	220	0.084	Worm
synapse assembly	GO:0007416	143	0.083
positive regulation of signaling	GO:0023056	243	0.081
protein import	GO:0017038	55	0.079
programmed cell death	GO:0012501	257	0.079
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.077
regulation of cell differentiation	GO:0045595	302	0.076
protein acetylation	GO:0006473	39	0.076
developmental maturation	GO:0021700	172	0.075
female meiotic division	GO:0007143	70	0.075
regulation of cell shape	GO:0008360	113	0.073
macromolecule deacylation	GO:0098732	11	0.072
notch signaling pathway	GO:0007219	120	0.072
negative regulation of cell cycle phase transition	GO:1901988	103	0.071
protein phosphorylation	GO:0006468	169	0.070
appendage morphogenesis	GO:0035107	397	0.067
positive regulation of signal transduction	GO:0009967	223	0.066
organic acid metabolic process	GO:0006082	103	0.066
cytokinetic process	GO:0032506	27	0.064
regulation of cellular component biogenesis	GO:0044087	201	0.062
protein catabolic process	GO:0030163	101	0.061
male meiosis cytokinesis	GO:0007112	26	0.061
cell maturation	GO:0048469	144	0.061
positive regulation of cellular component organization	GO:0051130	156	0.061
negative regulation of cell communication	GO:0010648	223	0.061
positive regulation of nervous system development	GO:0051962	69	0.059
protein localization to nucleus	GO:0034504	55	0.059
intracellular transport	GO:0046907	228	0.059
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.058
regulation of cell development	GO:0060284	215	0.056
larval development	GO:0002164	104	0.055	Worm
body morphogenesis	GO:0010171	2	0.055	Worm
oxoacid metabolic process	GO:0043436	103	0.055
carboxylic acid metabolic process	GO:0019752	92	0.054
cell division	GO:0051301	248	0.053
morphogenesis of a branching epithelium	GO:0061138	45	0.051
histone h4 k16 acetylation	GO:0043984	4	0.051	Fly
mitotic nuclear division	GO:0007067	213	0.051
regulation of cellular protein metabolic process	GO:0032268	243	0.050	Fly
segmentation	GO:0035282	207	0.049
regulation of growth	GO:0040008	233	0.048
negative regulation of protein metabolic process	GO:0051248	85	0.046
negative regulation of signal transduction	GO:0009968	206	0.046
gene silencing	GO:0016458	138	0.045
establishment of localization in cell	GO:0051649	402	0.045
negative regulation of gene expression epigenetic	GO:0045814	77	0.045
chromatin silencing	GO:0006342	76	0.045
protein localization to peroxisome	GO:0072662	2	0.045
negative regulation of phosphorus metabolic process	GO:0010563	45	0.044
compound eye development	GO:0048749	307	0.043
regulation of phosphorylation	GO:0042325	147	0.043
negative regulation of biosynthetic process	GO:0009890	277	0.042
negative regulation of multicellular organismal process	GO:0051241	142	0.042	Worm
positive regulation of transport	GO:0051050	92	0.042
positive regulation of rna metabolic process	GO:0051254	271	0.041	Mouse Rat
multicellular organismal reproductive behavior	GO:0033057	110	0.041
reproductive structure development	GO:0048608	74	0.041
regulation of response to stress	GO:0080134	200	0.040	Fly
protein acylation	GO:0043543	42	0.040
histone h3 k9 acetylation	GO:0043970	3	0.039
maintenance of protein location	GO:0045185	28	0.038
regulation of response to external stimulus	GO:0032101	115	0.038
maintenance of location in cell	GO:0051651	28	0.038
protein targeting	GO:0006605	64	0.037
cognition	GO:0050890	141	0.037
embryonic axis specification	GO:0000578	107	0.036
mitotic dna damage checkpoint	GO:0044773	74	0.036
determination of adult lifespan	GO:0008340	137	0.036
cellular macromolecular complex assembly	GO:0034622	153	0.035
lipid metabolic process	GO:0006629	121	0.035
protein complex biogenesis	GO:0070271	201	0.035
protein complex assembly	GO:0006461	200	0.034
regulation of wnt signaling pathway	GO:0030111	68	0.034
cellular response to chemical stimulus	GO:0070887	199	0.034	Rat
reproductive system development	GO:0061458	74	0.034
synapse organization	GO:0050808	196	0.033
appendage development	GO:0048736	401	0.033
regulation of synapse organization	GO:0050807	110	0.033
microtubule based movement	GO:0007018	51	0.033
positive regulation of autophagy	GO:0010508	21	0.033
negative regulation of mitotic cell cycle	GO:0045930	109	0.032
negative regulation of receptor activity	GO:2000272	3	0.031
reproductive behavior	GO:0019098	122	0.031
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.030	Mouse Rat
muscle structure development	GO:0061061	224	0.030
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.030
intracellular signal transduction	GO:0035556	300	0.030	Fly
autophagy	GO:0006914	108	0.030
larval midgut cell programmed cell death	GO:0035096	19	0.029
regulation of phosphate metabolic process	GO:0019220	210	0.029
imaginal disc derived wing morphogenesis	GO:0007476	337	0.028
nucleotide excision repair	GO:0006289	8	0.028
regulation of cell morphogenesis	GO:0022604	163	0.028
phagocytosis	GO:0006909	215	0.028
regulation of cellular amino acid metabolic process	GO:0006521	0	0.028
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.028
cell cycle checkpoint	GO:0000075	95	0.028	Fly
death	GO:0016265	284	0.027
protein ubiquitination	GO:0016567	70	0.027
embryonic pattern specification	GO:0009880	174	0.027
peptidyl lysine acetylation	GO:0018394	39	0.027
regulation of dendrite development	GO:0050773	37	0.027
single organism cellular localization	GO:1902580	180	0.027
protein transport	GO:0015031	155	0.026
positive regulation of biosynthetic process	GO:0009891	316	0.026	Mouse Rat
response to nutrient levels	GO:0031667	114	0.026
negative regulation of apoptotic process	GO:0043066	63	0.025
meiotic cell cycle process	GO:1903046	132	0.025
cellular response to starvation	GO:0009267	61	0.025
negative regulation of molecular function	GO:0044092	51	0.025
imaginal disc derived appendage development	GO:0048737	399	0.024
anatomical structure homeostasis	GO:0060249	97	0.024
neuroblast proliferation	GO:0007405	74	0.024
cytoplasmic transport	GO:0016482	130	0.024
negative regulation of neurogenesis	GO:0050768	53	0.023
negative regulation of developmental process	GO:0051093	201	0.023	Worm
regulation of cellular protein catabolic process	GO:1903362	44	0.023
regulation of synapse structure and activity	GO:0050803	128	0.023
negative regulation of organelle organization	GO:0010639	56	0.023
gliogenesis	GO:0042063	80	0.023
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.023
negative regulation of erbb signaling pathway	GO:1901185	29	0.022
single organism intracellular transport	GO:1902582	207	0.022
macroautophagy	GO:0016236	42	0.022
response to organic cyclic compound	GO:0014070	89	0.022
regulation of proteolysis	GO:0030162	87	0.022
compound eye morphogenesis	GO:0001745	249	0.022
skeletal muscle fiber development	GO:0048741	3	0.022
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.022	Mouse Rat
regulation of neuron projection development	GO:0010975	69	0.021
oviposition	GO:0018991	19	0.021
protein processing	GO:0016485	68	0.021
apoptotic signaling pathway	GO:0097190	27	0.021
positive regulation of protein deacetylation	GO:0090312	2	0.021
response to external biotic stimulus	GO:0043207	293	0.020
cell proliferation	GO:0008283	299	0.020
blastoderm segmentation	GO:0007350	159	0.020
multicellular organism growth	GO:0035264	46	0.020
regulation of chromosome organization	GO:0033044	64	0.020	Fly
male gamete generation	GO:0048232	201	0.020
development of primary sexual characteristics	GO:0045137	50	0.020
regulation of cellular response to stress	GO:0080135	89	0.019	Fly
covalent chromatin modification	GO:0016569	106	0.019
dendrite morphogenesis	GO:0048813	199	0.019
negative regulation of cellular protein metabolic process	GO:0032269	85	0.019
regulation of neurogenesis	GO:0050767	158	0.019
negative regulation of phosphate metabolic process	GO:0045936	45	0.019
regulation of molecular function	GO:0065009	217	0.019	Fly
response to extracellular stimulus	GO:0009991	116	0.019
spindle organization	GO:0007051	253	0.019
photoreceptor cell development	GO:0042461	96	0.018
oocyte construction	GO:0007308	112	0.018
establishment of protein localization	GO:0045184	163	0.018
regulation of catalytic activity	GO:0050790	185	0.018
cellular response to dna damage stimulus	GO:0006974	223	0.018
protein maturation	GO:0051604	71	0.017
protein modification by small protein conjugation	GO:0032446	79	0.017
chromatin organization	GO:0006325	207	0.017
regulation of phosphatase activity	GO:0010921	3	0.017
autophagic vacuole assembly	GO:0000045	2	0.017
nuclear import	GO:0051170	51	0.017
single organism catabolic process	GO:0044712	228	0.017
regulation of protein metabolic process	GO:0051246	256	0.017	Fly
regulation of chromosome segregation	GO:0051983	32	0.017
positive regulation of phosphate metabolic process	GO:0045937	139	0.017
endocytosis	GO:0006897	310	0.017	Worm
regulation of nervous system development	GO:0051960	248	0.017
regulation of cellular catabolic process	GO:0031329	157	0.017
establishment of protein localization to organelle	GO:0072594	62	0.017
somatic stem cell division	GO:0048103	37	0.017
response to other organism	GO:0051707	293	0.016
regulation of notch signaling pathway	GO:0008593	100	0.016
regulation of protein localization to nucleus	GO:1900180	29	0.016
anterior posterior axis specification embryo	GO:0008595	103	0.016
histone h4 acetylation	GO:0043967	13	0.016
development of primary male sexual characteristics	GO:0046546	9	0.016
multi multicellular organism process	GO:0044706	123	0.016
epithelial tube morphogenesis	GO:0060562	88	0.016
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.016
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.015
amine metabolic process	GO:0009308	12	0.015
regulation of gene expression epigenetic	GO:0040029	128	0.015	Fly
oocyte axis specification	GO:0007309	108	0.015
positive regulation of response to extracellular stimulus	GO:0032106	8	0.015
regulation of protein catabolic process	GO:0042176	55	0.015
regulation of cell death	GO:0010941	173	0.015
positive regulation of gene expression	GO:0010628	290	0.015	Mouse Rat
neuron projection guidance	GO:0097485	241	0.015
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.015
synaptic growth at neuromuscular junction	GO:0051124	119	0.015
cell motility	GO:0048870	251	0.015
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	26	0.015
erbb signaling pathway	GO:0038127	58	0.015
signal transduction in response to dna damage	GO:0042770	3	0.015	Fly
mapk cascade	GO:0000165	107	0.015
homeostatic process	GO:0042592	199	0.014
protein targeting to nucleus	GO:0044744	51	0.014
regulation of mitosis	GO:0007088	56	0.014
vesicle mediated transport	GO:0016192	381	0.014	Worm
negative regulation of peptidyl tyrosine phosphorylation	GO:0050732	6	0.014
mrna splice site selection	GO:0006376	1	0.014
regulation of phosphorus metabolic process	GO:0051174	210	0.014
cell aging	GO:0007569	2	0.014
regulation of g2 m transition of mitotic cell cycle	GO:0010389	15	0.014
golgi organization	GO:0007030	66	0.014
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.014
negative regulation of protein processing	GO:0010955	31	0.013
regulation of transport	GO:0051049	181	0.013
negative regulation of g2 m transition of mitotic cell cycle	GO:0010972	8	0.013
chromatin modification	GO:0016568	147	0.013
nucleocytoplasmic transport	GO:0006913	72	0.013
negative regulation of ras protein signal transduction	GO:0046580	13	0.013
regulation of mapk cascade	GO:0043408	92	0.013
morphogenesis of a branching structure	GO:0001763	45	0.013
muscle organ development	GO:0007517	127	0.013
negative regulation of phosphorylation	GO:0042326	35	0.012
regulation of autophagy	GO:0010506	62	0.012
protein polyubiquitination	GO:0000209	11	0.012
response to light stimulus	GO:0009416	124	0.012
negative regulation of programmed cell death	GO:0043069	72	0.012
protein import into nucleus	GO:0006606	51	0.012
regulation of protein processing	GO:0070613	32	0.012
post embryonic appendage morphogenesis	GO:0035120	385	0.012
regulation of hydrolase activity	GO:0051336	97	0.012
regulation of catabolic process	GO:0009894	170	0.012
imaginal disc derived leg morphogenesis	GO:0007480	80	0.012
actin cytoskeleton organization	GO:0030036	206	0.012
neurological system process	GO:0050877	358	0.012
cellular component assembly involved in morphogenesis	GO:0010927	151	0.012
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.012
pigment cell differentiation	GO:0050931	3	0.012
cellularization	GO:0007349	90	0.012
establishment of organelle localization	GO:0051656	122	0.011
tube morphogenesis	GO:0035239	191	0.011
regulation of epidermal growth factor activated receptor activity	GO:0007176	4	0.011
regulation of immune response	GO:0050776	118	0.011
developmental pigmentation	GO:0048066	68	0.011
oocyte differentiation	GO:0009994	145	0.011
regulation of dna metabolic process	GO:0051052	34	0.011
regulation of protein tyrosine kinase activity	GO:0061097	9	0.011
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.011
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.011
regulation of locomotion	GO:0040012	42	0.011
scf dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031146	1	0.011
g2 m transition of mitotic cell cycle	GO:0000086	19	0.011
nuclear transport	GO:0051169	72	0.011
cellular response to external stimulus	GO:0071496	66	0.011
myotube cell development	GO:0014904	3	0.011
dna templated transcription initiation	GO:0006352	25	0.011
tripartite regional subdivision	GO:0007351	103	0.011
positive regulation of protein metabolic process	GO:0051247	128	0.011
positive regulation of phosphorylation	GO:0042327	87	0.011
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.011
molting cycle	GO:0042303	56	0.011
response to wounding	GO:0009611	94	0.011
regulation of cellular amine metabolic process	GO:0033238	3	0.011
eye photoreceptor cell differentiation	GO:0001754	145	0.011
stem cell proliferation	GO:0072089	88	0.011
histone h4 k12 acetylation	GO:0043983	2	0.010
regulation of cytokinesis	GO:0032465	3	0.010
positive regulation of catabolic process	GO:0009896	105	0.010
positive regulation of cell cycle process	GO:0090068	28	0.010
negative regulation of cell death	GO:0060548	81	0.010
sex differentiation	GO:0007548	81	0.010
regulation of cell projection organization	GO:0031344	92	0.010

Tip60 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.028
disease of anatomical entity	DOID:7	0.028
disease of cellular proliferation	DOID:14566	0.023
cancer	DOID:162	0.022
organ system cancer	DOID:0050686	0.022

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network