IMP: Integrative Multi-species Prediction

Drosophila melanogaster

87 known processes

pelo (Dmel_CG3959)

pelota

(Aliases: Dmel\CG3959,CG3959,ms(2)01559)

Entrez: 34286
FLYBASE: FBgn0011207
UniProtKB: P48612

Process Predictions
Disease Predictions

pelo biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
organelle fission	GO:0048285	340	0.973
meiotic cell cycle	GO:0051321	171	0.969
spermatogenesis	GO:0007283	200	0.935
germline stem cell asymmetric division	GO:0098728	15	0.934
male gamete generation	GO:0048232	201	0.931
male meiosis	GO:0007140	52	0.865
negative regulation of gene expression	GO:0010629	387	0.803
positive regulation of macromolecule metabolic process	GO:0010604	405	0.677
meiotic cell cycle process	GO:1903046	132	0.629
spermatid development	GO:0007286	98	0.601
nuclear division	GO:0000280	332	0.552
oocyte construction	GO:0007308	112	0.493
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.456
positive regulation of rna metabolic process	GO:0051254	271	0.453
fusome organization	GO:0045478	13	0.432
meiotic spindle organization	GO:0000212	36	0.432
eye development	GO:0001654	323	0.401
oocyte differentiation	GO:0009994	145	0.388
oocyte development	GO:0048599	124	0.387
spermatid differentiation	GO:0048515	114	0.364
cellular macromolecule catabolic process	GO:0044265	136	0.359
male meiosis cytokinesis	GO:0007112	26	0.341
cell proliferation	GO:0008283	299	0.336	Mouse
meiosis i	GO:0007127	59	0.330
positive regulation of biosynthetic process	GO:0009891	316	0.316
epithelial cell development	GO:0002064	274	0.315
compound eye morphogenesis	GO:0001745	249	0.310
mrna metabolic process	GO:0016071	124	0.304
meiotic nuclear division	GO:0007126	151	0.298
sensory organ morphogenesis	GO:0090596	260	0.293
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.292
meiotic cytokinesis	GO:0033206	33	0.281
positive regulation of cellular biosynthetic process	GO:0031328	316	0.268
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.260
regulation of cellular component biogenesis	GO:0044087	201	0.243
dorsal ventral axis specification	GO:0009950	66	0.242
kidney development	GO:0001822	3	0.232
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.229
germ line stem cell maintenance	GO:0030718	50	0.212
mitotic nuclear division	GO:0007067	213	0.204
embryo development ending in birth or egg hatching	GO:0009792	152	0.193
response to organic substance	GO:0010033	284	0.186
posttranscriptional regulation of gene expression	GO:0010608	145	0.185
oocyte axis specification	GO:0007309	108	0.163
epithelial cell differentiation	GO:0030855	322	0.158
compound eye photoreceptor cell differentiation	GO:0001751	140	0.155
regulation of developmental growth	GO:0048638	174	0.154
eye morphogenesis	GO:0048592	260	0.152
stem cell division	GO:0017145	69	0.151
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.149
chromosome segregation	GO:0007059	157	0.142
cellular response to organic substance	GO:0071310	132	0.136
ovarian fusome organization	GO:0030723	11	0.134
negative regulation of cell differentiation	GO:0045596	143	0.133
regulation of protein complex disassembly	GO:0043244	29	0.130
oocyte dorsal ventral axis specification	GO:0007310	34	0.125
stem cell maintenance	GO:0019827	67	0.123
positive regulation of protein metabolic process	GO:0051247	128	0.121
phosphorylation	GO:0016310	294	0.115
cystoblast division	GO:0007282	10	0.115
regulation of organelle organization	GO:0033043	196	0.115
nucleobase containing compound catabolic process	GO:0034655	165	0.113
negative regulation of developmental process	GO:0051093	201	0.113
negative regulation of cellular metabolic process	GO:0031324	382	0.112
multicellular organism growth	GO:0035264	46	0.109
organic substance catabolic process	GO:1901575	308	0.108
regulation of anatomical structure morphogenesis	GO:0022603	242	0.107
positive regulation of gene expression	GO:0010628	290	0.106
actin filament based process	GO:0030029	220	0.104
rna processing	GO:0006396	147	0.104
regulation of multicellular organismal development	GO:2000026	414	0.103
regulation of cell cycle process	GO:0010564	181	0.101
cellular macromolecule localization	GO:0070727	220	0.101
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.101
regulation of multicellular organism growth	GO:0040014	40	0.098
photoreceptor cell differentiation	GO:0046530	170	0.092
cellular component disassembly	GO:0022411	46	0.092
cell division	GO:0051301	248	0.092
reproductive system development	GO:0061458	74	0.091
protein complex biogenesis	GO:0070271	201	0.090
positive regulation of transcription dna templated	GO:0045893	266	0.090
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.090
immune system process	GO:0002376	347	0.089
axon guidance	GO:0007411	233	0.088
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.088
compound eye development	GO:0048749	307	0.088
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.088
regulation of protein metabolic process	GO:0051246	256	0.086
negative regulation of cellular component organization	GO:0051129	108	0.086
positive regulation of cell communication	GO:0010647	250	0.085
positive regulation of rna biosynthetic process	GO:1902680	266	0.081
response to oxygen containing compound	GO:1901700	200	0.081
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.081
dorsal ventral pattern formation	GO:0009953	133	0.078
female germ line cyst formation	GO:0048135	42	0.078
protein localization to organelle	GO:0033365	82	0.078
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.077
regulation of cell differentiation	GO:0045595	302	0.076
synapse organization	GO:0050808	196	0.076
gland development	GO:0048732	191	0.074
macromolecule catabolic process	GO:0009057	161	0.072
cytoskeleton dependent cytokinesis	GO:0061640	81	0.070
negative regulation of phosphatase activity	GO:0010923	3	0.069
negative regulation of transcription dna templated	GO:0045892	237	0.065
positive regulation of developmental process	GO:0051094	143	0.065
negative regulation of cell communication	GO:0010648	223	0.064
transcription from rna polymerase ii promoter	GO:0006366	368	0.064
negative regulation of rna metabolic process	GO:0051253	251	0.063
hemopoiesis	GO:0030097	46	0.061
rna interference	GO:0016246	27	0.061
fertilization	GO:0009566	26	0.060
germarium derived oocyte differentiation	GO:0030706	29	0.060
vesicle mediated transport	GO:0016192	381	0.059
cytoplasmic microtubule organization	GO:0031122	22	0.059
heterocycle catabolic process	GO:0046700	166	0.059
regulation of microtubule based process	GO:0032886	49	0.058
ovarian follicle cell development	GO:0030707	248	0.057
chromosome organization	GO:0051276	360	0.055	Mouse
positive regulation of multicellular organism growth	GO:0040018	21	0.055
single fertilization	GO:0007338	24	0.055
catabolic process	GO:0009056	409	0.053
positive regulation of catabolic process	GO:0009896	105	0.053
apoptotic process	GO:0006915	159	0.052
positive regulation of phosphate metabolic process	GO:0045937	139	0.052
cell maturation	GO:0048469	144	0.050
mitotic cell cycle checkpoint	GO:0007093	88	0.050
endocytosis	GO:0006897	310	0.048
reproductive structure development	GO:0048608	74	0.046
carbohydrate derivative metabolic process	GO:1901135	217	0.045
regulation of phosphorus metabolic process	GO:0051174	210	0.044
lateral inhibition	GO:0046331	206	0.044
mrna processing	GO:0006397	104	0.043
organophosphate biosynthetic process	GO:0090407	46	0.042
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.042
regulation of cell cycle	GO:0051726	291	0.041
regulation of phosphate metabolic process	GO:0019220	210	0.041
regulation of phosphorylation	GO:0042325	147	0.041
small molecule metabolic process	GO:0044281	305	0.041
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.041
regulation of cytoskeleton organization	GO:0051493	89	0.040
posttranscriptional gene silencing by rna	GO:0035194	45	0.040
axis specification	GO:0009798	167	0.039
negative regulation of cellular biosynthetic process	GO:0031327	277	0.038
cellular response to chemical stimulus	GO:0070887	199	0.038
stem cell differentiation	GO:0048863	117	0.038
oocyte maturation	GO:0001556	3	0.037
cellular response to organic cyclic compound	GO:0071407	32	0.037
regulation of response to stress	GO:0080134	200	0.036
regulation of catabolic process	GO:0009894	170	0.036
developmental maturation	GO:0021700	172	0.036
nucleobase containing small molecule metabolic process	GO:0055086	174	0.035
regulation of translation	GO:0006417	56	0.035
homeostatic process	GO:0042592	199	0.035
regulation of molecular function	GO:0065009	217	0.034
cellular macromolecular complex assembly	GO:0034622	153	0.034
negative regulation of biosynthetic process	GO:0009890	277	0.034
negative regulation of signaling	GO:0023057	219	0.033
female germ line stem cell asymmetric division	GO:0048132	14	0.033
positive regulation of atp catabolic process	GO:1903291	3	0.032
cytokinesis	GO:0000910	90	0.032
mitotic cell cycle phase transition	GO:0044772	138	0.032
protein phosphorylation	GO:0006468	169	0.032
organonitrogen compound metabolic process	GO:1901564	318	0.032
positive regulation of translation	GO:0045727	12	0.032
positive regulation of signaling	GO:0023056	243	0.031
immune system development	GO:0002520	57	0.031
regulation of immune system process	GO:0002682	176	0.031
regulation of oocyte development	GO:0060281	27	0.031
germarium derived female germ line cyst formation	GO:0030727	42	0.030
anatomical structure homeostasis	GO:0060249	97	0.030
positive regulation of phosphorus metabolic process	GO:0010562	139	0.030
spindle assembly	GO:0051225	80	0.030
positive regulation of multicellular organismal process	GO:0051240	143	0.030
gonad development	GO:0008406	50	0.030
regulation of mitotic cell cycle	GO:0007346	190	0.030
germline ring canal formation	GO:0030725	13	0.029
regulation of cell shape	GO:0008360	113	0.028
organophosphate metabolic process	GO:0019637	195	0.028
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.028
endomembrane system organization	GO:0010256	119	0.028
positive regulation of cellular component organization	GO:0051130	156	0.027
single organism cellular localization	GO:1902580	180	0.027
regulation of gene expression epigenetic	GO:0040029	128	0.027
female germ line stem cell maintenance	GO:0036099	8	0.027
ribonucleoprotein complex subunit organization	GO:0071826	28	0.027
protein import	GO:0017038	55	0.026
positive regulation of catalytic activity	GO:0043085	118	0.026
actin filament organization	GO:0007015	126	0.026
establishment of protein localization to organelle	GO:0072594	62	0.026
synaptic transmission	GO:0007268	288	0.025
macromolecular complex disassembly	GO:0032984	37	0.025
cellular nitrogen compound catabolic process	GO:0044270	165	0.025
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.025
protein complex assembly	GO:0006461	200	0.025
vesicle organization	GO:0016050	44	0.024
pronuclear migration	GO:0035046	4	0.024
modification dependent protein catabolic process	GO:0019941	78	0.024
cellular protein complex disassembly	GO:0043624	35	0.024
regulation of growth	GO:0040008	233	0.024
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.024
actin cytoskeleton organization	GO:0030036	206	0.023
intracellular signal transduction	GO:0035556	300	0.023
regulation of nucleocytoplasmic transport	GO:0046822	35	0.023
cellular protein catabolic process	GO:0044257	83	0.023
regulation of dna metabolic process	GO:0051052	34	0.023
negative regulation of organelle organization	GO:0010639	56	0.023
cell adhesion	GO:0007155	136	0.022
protein catabolic process	GO:0030163	101	0.022
microtubule depolymerization	GO:0007019	25	0.022
protein import into nucleus	GO:0006606	51	0.022
positive regulation of response to stimulus	GO:0048584	323	0.021
cellular catabolic process	GO:0044248	372	0.021
development of primary sexual characteristics	GO:0045137	50	0.021
protein modification process	GO:0036211	438	0.021
regulation of protein kinase activity	GO:0045859	51	0.021
negative regulation of mitotic cell cycle	GO:0045930	109	0.021
positive regulation of organelle organization	GO:0010638	65	0.021
positive regulation of signal transduction	GO:0009967	223	0.021
positive regulation of cellular protein metabolic process	GO:0032270	118	0.021
protein complex disassembly	GO:0043241	36	0.021
eye photoreceptor cell differentiation	GO:0001754	145	0.021
photoreceptor cell development	GO:0042461	96	0.020
cell cycle phase transition	GO:0044770	140	0.020
negative regulation of rna biosynthetic process	GO:1902679	240	0.019
regulation of transport	GO:0051049	181	0.019
spindle organization	GO:0007051	253	0.019
single organism biosynthetic process	GO:0044711	206	0.019
programmed cell death	GO:0012501	257	0.018
positive regulation of growth	GO:0045927	75	0.018
cell death	GO:0008219	279	0.018
establishment of localization in cell	GO:0051649	402	0.018
spindle assembly involved in male meiosis	GO:0007053	5	0.018
regulation of establishment of protein localization	GO:0070201	61	0.018
response to organic cyclic compound	GO:0014070	89	0.018
compound eye photoreceptor development	GO:0042051	78	0.018
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.018
regulation of kinase activity	GO:0043549	53	0.018
segmentation	GO:0035282	207	0.017
regulation of nervous system development	GO:0051960	248	0.017
organic cyclic compound catabolic process	GO:1901361	168	0.017
neuromuscular junction development	GO:0007528	149	0.017
sister chromatid segregation	GO:0000819	92	0.017
cellular protein complex assembly	GO:0043623	71	0.016
purine ribonucleoside metabolic process	GO:0046128	127	0.016
positive regulation of cellular catabolic process	GO:0031331	95	0.016
nuclear envelope organization	GO:0006998	7	0.016
protein polymerization	GO:0051258	42	0.016
mitochondrion degradation	GO:0000422	8	0.016
spindle stabilization	GO:0043146	14	0.016
pole plasm rna localization	GO:0007316	52	0.015
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.015
nucleotide catabolic process	GO:0009166	109	0.015
ras protein signal transduction	GO:0007265	88	0.015
positive regulation of immune system process	GO:0002684	68	0.015
regulation of microtubule polymerization or depolymerization	GO:0031110	27	0.015
regulation of protein modification process	GO:0031399	112	0.015
organelle localization	GO:0051640	148	0.015
asymmetric stem cell division	GO:0098722	49	0.015
female gonad development	GO:0008585	12	0.015
regulation of execution phase of apoptosis	GO:1900117	5	0.015
negative regulation of cellular protein metabolic process	GO:0032269	85	0.014
regulation of cellular catabolic process	GO:0031329	157	0.014
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.014
protein localization	GO:0008104	284	0.014
gene silencing by rna	GO:0031047	57	0.014
dorsal appendage formation	GO:0046843	47	0.014
chaeta development	GO:0022416	97	0.014
modification dependent macromolecule catabolic process	GO:0043632	79	0.014
cellular response to oxygen containing compound	GO:1901701	79	0.013
protein transmembrane transport	GO:0071806	4	0.013
mitotic sister chromatid segregation	GO:0000070	87	0.013
proteolysis	GO:0006508	192	0.013
regulation of intracellular signal transduction	GO:1902531	236	0.013
transmembrane transport	GO:0055085	139	0.013
regulation of cell proliferation	GO:0042127	163	0.013
regulation of cell cycle phase transition	GO:1901987	130	0.013
negative regulation of protein metabolic process	GO:0051248	85	0.013
regulation of protein complex assembly	GO:0043254	42	0.013
positive regulation of immune response	GO:0050778	63	0.013
response to nitrogen compound	GO:1901698	90	0.013
g2 dna damage checkpoint	GO:0031572	69	0.013
sex differentiation	GO:0007548	81	0.013
spermatocyte division	GO:0048137	13	0.012
negative regulation of cell cycle	GO:0045786	116	0.012
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.012
response to biotic stimulus	GO:0009607	294	0.012
regulation of dna recombination	GO:0000018	4	0.012
urogenital system development	GO:0001655	72	0.012
stem cell development	GO:0048864	79	0.012
growth	GO:0040007	359	0.012
meiotic cell cycle phase transition	GO:0044771	4	0.012
regulation of vesicle mediated transport	GO:0060627	59	0.012
morphogenesis of an epithelium	GO:0002009	276	0.012
nucleus organization	GO:0006997	45	0.012
negative regulation of microtubule polymerization or depolymerization	GO:0031111	21	0.012
positive regulation of hydrolase activity	GO:0051345	78	0.012
response to dsrna	GO:0043331	15	0.012
nucleoside metabolic process	GO:0009116	127	0.012
response to abiotic stimulus	GO:0009628	341	0.012
blastoderm segmentation	GO:0007350	159	0.011
kidney epithelium development	GO:0072073	3	0.011
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.011
proteasomal protein catabolic process	GO:0010498	59	0.011
response to endogenous stimulus	GO:0009719	119	0.011
translation	GO:0006412	69	0.011
regulation of meiosis	GO:0040020	3	0.011
aging	GO:0007568	143	0.011
lipid biosynthetic process	GO:0008610	46	0.011
rrna processing	GO:0006364	3	0.011
germarium derived egg chamber formation	GO:0007293	101	0.011
regulation of cellular ketone metabolic process	GO:0010565	3	0.011
regulation of protein phosphorylation	GO:0001932	64	0.011
regulation of actin filament polymerization	GO:0030833	25	0.011
regulation of cell morphogenesis	GO:0022604	163	0.011
synaptic growth at neuromuscular junction	GO:0051124	119	0.011
response to bacterium	GO:0009617	198	0.011
membrane organization	GO:0061024	112	0.011
ncrna metabolic process	GO:0034660	43	0.011
aromatic compound catabolic process	GO:0019439	166	0.010
death	GO:0016265	284	0.010
positive regulation of defense response	GO:0031349	59	0.010
germ line cyst formation	GO:0048134	44	0.010
production of small rna involved in gene silencing by rna	GO:0070918	15	0.010
regulation of mrna catabolic process	GO:0061013	5	0.010
regulation of defense response	GO:0031347	102	0.010
small gtpase mediated signal transduction	GO:0007264	88	0.010
carbohydrate derivative biosynthetic process	GO:1901137	85	0.010
negative regulation of phosphate metabolic process	GO:0045936	45	0.010
posttranscriptional gene silencing	GO:0016441	46	0.010
positive regulation of protein localization to nucleus	GO:1900182	21	0.010
regulation of protein catabolic process	GO:0042176	55	0.010
response to external biotic stimulus	GO:0043207	293	0.010

pelo disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.013
	nervous system disease	DOID:863	0	0.010

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network