IMP: Integrative Multi-species Prediction

Drosophila melanogaster

374 known processes

Ras85D (Dmel_CG9375)

Ras oncogene at 85D

(Aliases: EK3-4,DRas,CG9375,Dras85D,dRas1,l(3)06677,ras,RAS1,Ras-1,ras85B,Dm Ras1,Dras,Su(tor)3-2,dras1,RTK,RasI,C-ras1,RasV12,RAS,D-ras1,DRas85D/Ras,Ras[V12],ras85D,fs(3)05703,E(sev)3C,ras1,dRas85D,S35097,D-ras-1,Dras1,Ras1,D-Ras1,D-Ras,l(3)s1747,E(faf),dRas,ras 1,dRAS1,DRAS1,RAS85D,Ras,Dmel\CG9375,Ras1/RAs85D,Dmras85D,p21[Ras1])

Entrez: 41140
FLYBASE: FBgn0003205
UniProtKB: P08646

Process Predictions
Disease Predictions

Ras85D biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
border follicle cell migration	GO:0007298	113	1.000
ovarian follicle cell development	GO:0030707	248	1.000
epithelial cell migration	GO:0010631	148	1.000
regulation of neurogenesis	GO:0050767	158	1.000
chorion containing eggshell formation	GO:0007304	105	1.000
synaptic transmission	GO:0007268	288	1.000	Mouse
positive regulation of macromolecule metabolic process	GO:0010604	405	1.000	Human Yeast Mouse Rat
post embryonic appendage morphogenesis	GO:0035120	385	1.000
ovarian follicle cell migration	GO:0007297	121	1.000
columnar cuboidal epithelial cell development	GO:0002066	249	1.000
morphogenesis of an epithelium	GO:0002009	276	1.000	Mouse Fly
regulation of nervous system development	GO:0051960	248	1.000
regulation of apoptotic signaling pathway	GO:2001233	10	1.000
regulation of multicellular organism growth	GO:0040014	40	1.000
ras protein signal transduction	GO:0007265	88	1.000	Human Mouse Rat Fly
appendage morphogenesis	GO:0035107	397	1.000
regulation of cellular component biogenesis	GO:0044087	201	0.999	Human
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.999
hemocyte differentiation	GO:0042386	38	0.999
positive regulation of nervous system development	GO:0051962	69	0.999
cell motility	GO:0048870	251	0.999
positive regulation of protein serine threonine kinase activity	GO:0071902	15	0.999	Human
learning or memory	GO:0007611	141	0.999	Mouse
cognition	GO:0050890	141	0.999	Mouse
germarium derived egg chamber formation	GO:0007293	101	0.999
positive regulation of developmental process	GO:0051094	143	0.998
epithelium migration	GO:0090132	148	0.998
response to abiotic stimulus	GO:0009628	341	0.998	Mouse
regulation of growth	GO:0040008	233	0.998
stem cell differentiation	GO:0048863	117	0.998
regulation of cellular protein metabolic process	GO:0032268	243	0.998	Human
regulation of catabolic process	GO:0009894	170	0.998
regulation of protein kinase activity	GO:0045859	51	0.998	Human
tissue migration	GO:0090130	155	0.998
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.997	Human Yeast Rat Worm
cell migration	GO:0016477	238	0.997
establishment or maintenance of cell polarity	GO:0007163	167	0.997
regulation of autophagy	GO:0010506	62	0.997
regulation of cellular catabolic process	GO:0031329	157	0.997
eggshell formation	GO:0030703	105	0.997
positive regulation of cellular protein metabolic process	GO:0032270	118	0.996	Human
positive regulation of protein metabolic process	GO:0051247	128	0.996	Human
stem cell development	GO:0048864	79	0.995
cell cycle phase transition	GO:0044770	140	0.995	Human
actin cytoskeleton organization	GO:0030036	206	0.995	Human Mouse
autophagy	GO:0006914	108	0.995
spermatogenesis	GO:0007283	200	0.995
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.994	Human
learning	GO:0007612	75	0.993	Mouse
negative regulation of cell cycle	GO:0045786	116	0.993	Human
eye antennal disc morphogenesis	GO:0007455	34	0.992
regulation of cell cycle process	GO:0010564	181	0.992	Human
regulation of cell cycle	GO:0051726	291	0.992	Human
regulation of kinase activity	GO:0043549	53	0.991	Human
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.991
establishment of protein localization	GO:0045184	163	0.991
negative regulation of macroautophagy	GO:0016242	6	0.991
negative regulation of cell differentiation	GO:0045596	143	0.991
regulation of synaptic plasticity	GO:0048167	14	0.990	Mouse
renal tubule development	GO:0061326	64	0.989
dorsal appendage formation	GO:0046843	47	0.989
stem cell maintenance	GO:0019827	67	0.989
negative regulation of autophagy	GO:0010507	16	0.989
regulation of anatomical structure morphogenesis	GO:0022603	242	0.988
actin filament based process	GO:0030029	220	0.988	Human Mouse
positive regulation of multicellular organismal process	GO:0051240	143	0.988
tube morphogenesis	GO:0035239	191	0.987
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.987	Human Yeast
tube development	GO:0035295	244	0.987
negative regulation of cell cycle phase transition	GO:1901988	103	0.987	Human
positive regulation of photoreceptor cell differentiation	GO:0046534	12	0.986
imaginal disc derived appendage development	GO:0048737	399	0.986
regulation of developmental growth	GO:0048638	174	0.986
segmentation	GO:0035282	207	0.986
cell fate specification	GO:0001708	71	0.985	Worm
compound eye photoreceptor cell differentiation	GO:0001751	140	0.984	Fly
peptidyl amino acid modification	GO:0018193	105	0.984
digestive tract morphogenesis	GO:0048546	127	0.983
dna metabolic process	GO:0006259	227	0.983	Human Rat
regulation of intracellular protein transport	GO:0033157	46	0.981
response to organic substance	GO:0010033	284	0.980
dorsal ventral axis specification ovarian follicular epithelium	GO:0008069	13	0.980
regulation of programmed cell death	GO:0043067	152	0.980
regulation of protein transport	GO:0051223	57	0.979
eye morphogenesis	GO:0048592	260	0.978
organelle fission	GO:0048285	340	0.978
developmental growth	GO:0048589	280	0.978
regulation of dna metabolic process	GO:0051052	34	0.977	Human Rat
embryonic pattern specification	GO:0009880	174	0.976
oocyte differentiation	GO:0009994	145	0.975
imaginal disc derived wing morphogenesis	GO:0007476	337	0.974
purine ribonucleotide catabolic process	GO:0009154	109	0.974
gliogenesis	GO:0042063	80	0.973
organic substance transport	GO:0071702	257	0.973
synapse organization	GO:0050808	196	0.973
multicellular organism growth	GO:0035264	46	0.973
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.972	Human
appendage development	GO:0048736	401	0.972
negative regulation of cellular catabolic process	GO:0031330	34	0.972
cell cycle g1 s phase transition	GO:0044843	31	0.971
positive regulation of protein kinase activity	GO:0045860	25	0.971	Human
response to radiation	GO:0009314	155	0.970	Mouse
positive regulation of multicellular organism growth	GO:0040018	21	0.970
protein transport	GO:0015031	155	0.970
cell division	GO:0051301	248	0.969
regulation of neuron differentiation	GO:0045664	103	0.969
phosphorylation	GO:0016310	294	0.969
mapk cascade	GO:0000165	107	0.967
muscle structure development	GO:0061061	224	0.965	Mouse Worm
dendrite development	GO:0016358	204	0.964
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.964
regulation of cellular protein catabolic process	GO:1903362	44	0.963
mitotic cell cycle phase transition	GO:0044772	138	0.963	Human
r3 r4 cell fate commitment	GO:0007464	10	0.961	Fly
regulation of apoptotic process	GO:0042981	130	0.960
eggshell chorion assembly	GO:0007306	66	0.960
meiotic cell cycle	GO:0051321	171	0.959	Yeast
positive regulation of cellular component organization	GO:0051130	156	0.959	Human
negative regulation of cell cycle process	GO:0010948	109	0.957	Human
regulation of synaptic transmission	GO:0050804	69	0.957	Mouse
central nervous system development	GO:0007417	201	0.955
cellular macromolecule localization	GO:0070727	220	0.955
male gamete generation	GO:0048232	201	0.955
glial cell migration	GO:0008347	31	0.954
kidney epithelium development	GO:0072073	3	0.954
regulation of multicellular organismal development	GO:2000026	414	0.953
regulation of cell death	GO:0010941	173	0.952
transcription from rna polymerase ii promoter	GO:0006366	368	0.951	Human
synaptic growth at neuromuscular junction	GO:0051124	119	0.951
positive regulation of cell cycle	GO:0045787	43	0.948
signal transduction by phosphorylation	GO:0023014	107	0.947
death	GO:0016265	284	0.946
negative regulation of catabolic process	GO:0009895	36	0.946
regulation of pathway restricted smad protein phosphorylation	GO:0060393	1	0.946
pathway restricted smad protein phosphorylation	GO:0060389	1	0.945
intracellular transport	GO:0046907	228	0.944
response to oxygen containing compound	GO:1901700	200	0.943
positive regulation of protein phosphorylation	GO:0001934	34	0.943	Human
regulation of protein catabolic process	GO:0042176	55	0.943
response to extracellular stimulus	GO:0009991	116	0.940
intracellular signal transduction	GO:0035556	300	0.939
small gtpase mediated signal transduction	GO:0007264	88	0.939	Human Mouse Rat Fly
negative regulation of cellular metabolic process	GO:0031324	382	0.939
response to nitrogen compound	GO:1901698	90	0.936
positive regulation of proteolysis	GO:0045862	52	0.935
tissue morphogenesis	GO:0048729	297	0.935	Mouse Fly
positive regulation of cellular biosynthetic process	GO:0031328	316	0.933	Human Yeast Rat
regulation of proteasomal protein catabolic process	GO:0061136	39	0.933
regulation of protein phosphorylation	GO:0001932	64	0.932	Human
positive regulation of pathway restricted smad protein phosphorylation	GO:0010862	1	0.931
negative regulation of signaling	GO:0023057	219	0.930
regulation of cytoskeleton organization	GO:0051493	89	0.930	Human
axon development	GO:0061564	297	0.928
circulatory system development	GO:0072359	82	0.928	Zebrafish
regulation of protein metabolic process	GO:0051246	256	0.928	Human
growth	GO:0040007	359	0.924
regulation of catalytic activity	GO:0050790	185	0.924	Human Yeast Worm
nuclear transport	GO:0051169	72	0.924
protein complex assembly	GO:0006461	200	0.924	Rat
head development	GO:0060322	135	0.923
negative regulation of mitotic cell cycle	GO:0045930	109	0.923	Human
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded	GO:0008071	1	0.923
heart development	GO:0007507	82	0.921	Zebrafish
positive regulation of protein modification process	GO:0031401	58	0.916	Human
cellular protein localization	GO:0034613	160	0.914
regulation of cytoplasmic transport	GO:1903649	47	0.914
cellular response to growth factor stimulus	GO:0071363	30	0.914
sensory organ morphogenesis	GO:0090596	260	0.912
regulation of map kinase activity	GO:0043405	17	0.912	Human
germ line stem cell maintenance	GO:0030718	50	0.910
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.908
negative regulation of cell communication	GO:0010648	223	0.907
r7 cell differentiation	GO:0045466	43	0.905
establishment of localization in cell	GO:0051649	402	0.905
macroautophagy	GO:0016236	42	0.905
lateral inhibition	GO:0046331	206	0.902
positive regulation of signal transduction	GO:0009967	223	0.900
regulation of organelle organization	GO:0033043	196	0.898	Human
eye photoreceptor cell differentiation	GO:0001754	145	0.898	Fly
negative regulation of synapse assembly	GO:0051964	39	0.896
regulation of establishment of protein localization	GO:0070201	61	0.895
synaptic vesicle localization	GO:0097479	53	0.895
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.892	Human Yeast Rat
vesicle localization	GO:0051648	55	0.890
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.889
regulation of cell shape	GO:0008360	113	0.889
positive regulation of developmental growth	GO:0048639	62	0.888
oocyte morphogenesis	GO:0048601	3	0.887
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.887	Worm
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.886	Worm
regulation of cell fate specification	GO:0042659	27	0.884	Worm
regulation of cell morphogenesis	GO:0022604	163	0.884	Fly
dendrite regeneration	GO:0031104	2	0.883
positive regulation of biosynthetic process	GO:0009891	316	0.882	Human Yeast Rat
cellular protein catabolic process	GO:0044257	83	0.877
dendrite morphogenesis	GO:0048813	199	0.875
regionalization	GO:0003002	416	0.872
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.872	Human
stem cell division	GO:0017145	69	0.871
spermatid development	GO:0007286	98	0.865
cell growth	GO:0016049	108	0.865
neurological system process	GO:0050877	358	0.864	Mouse
regulation of nucleocytoplasmic transport	GO:0046822	35	0.861
positive regulation of phosphorus metabolic process	GO:0010562	139	0.861
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.855	Human
positive regulation of phosphate metabolic process	GO:0045937	139	0.855
negative regulation of response to external stimulus	GO:0032102	22	0.848
blastoderm segmentation	GO:0007350	159	0.848
localization of cell	GO:0051674	257	0.847
positive regulation of protein transport	GO:0051222	37	0.845
positive regulation of response to stimulus	GO:0048584	323	0.844
positive regulation of cell development	GO:0010720	61	0.843
regulation of macroautophagy	GO:0016241	15	0.842
proteasomal protein catabolic process	GO:0010498	59	0.841
regulation of mitotic cell cycle	GO:0007346	190	0.841	Human
positive regulation of catabolic process	GO:0009896	105	0.840	Human Worm
negative regulation of apoptotic signaling pathway	GO:2001234	5	0.837
negative regulation of cell proliferation	GO:0008285	69	0.836	Human
regulation of cell proliferation involved in compound eye morphogenesis	GO:2000495	2	0.835
regulation of proteolysis	GO:0030162	87	0.831
single organism intracellular transport	GO:1902582	207	0.831
cellular response to organic substance	GO:0071310	132	0.829
positive regulation of neurogenesis	GO:0050769	41	0.826
positive regulation of phosphorylation	GO:0042327	87	0.823
regulation of transport	GO:0051049	181	0.821
single organism nuclear import	GO:1902593	51	0.819
brain development	GO:0007420	120	0.815
regulation of cell differentiation	GO:0045595	302	0.806
malpighian tubule development	GO:0072002	64	0.793
nucleobase containing compound catabolic process	GO:0034655	165	0.789
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.786
apoptotic signaling pathway	GO:0097190	27	0.786
protein catabolic process	GO:0030163	101	0.784
negative regulation of immune system process	GO:0002683	50	0.783	Fly
regulation of planar cell polarity pathway involved in axis elongation	GO:2000040	2	0.781
zygotic specification of dorsal ventral axis	GO:0007352	3	0.780
gland morphogenesis	GO:0022612	145	0.780
response to alcohol	GO:0097305	95	0.780
oocyte fate commitment	GO:0048600	2	0.778
positive regulation of signaling	GO:0023056	243	0.776
nucleocytoplasmic transport	GO:0006913	72	0.776
negative regulation of response to nutrient levels	GO:0032108	6	0.775
regulation of phosphorus metabolic process	GO:0051174	210	0.772
glial cell differentiation	GO:0010001	35	0.767
apoptotic process	GO:0006915	159	0.765
telencephalon development	GO:0021537	2	0.763
ubiquitin dependent protein catabolic process	GO:0006511	78	0.757
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	13	0.756
guanosine containing compound catabolic process	GO:1901069	74	0.756
positive regulation of cell differentiation	GO:0045597	64	0.754
regulation of nuclear division	GO:0051783	58	0.749
macromolecular complex assembly	GO:0065003	256	0.749	Rat
meiotic nuclear envelope disassembly	GO:0051078	2	0.747
g1 s transition of mitotic cell cycle	GO:0000082	31	0.746
regulation of intracellular signal transduction	GO:1902531	236	0.745
cellular catabolic process	GO:0044248	372	0.744
germ line stem cell division	GO:0042078	25	0.743
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.742
regulation of lipid kinase activity	GO:0043550	2	0.729
synapse assembly	GO:0007416	143	0.724
meiotic cell cycle process	GO:1903046	132	0.722	Yeast
protein modification process	GO:0036211	438	0.717	Human
regulation of photoreceptor cell differentiation	GO:0046532	34	0.711
mitotic spindle organization	GO:0007052	220	0.707
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.705	Human Mouse Rat Worm
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.702
regulation of immune system process	GO:0002682	176	0.699
hindgut morphogenesis	GO:0007442	58	0.698
axon ensheathment	GO:0008366	10	0.698
organic hydroxy compound metabolic process	GO:1901615	83	0.698
regulation of hemocyte differentiation	GO:0045610	22	0.697
positive regulation of cellular amine metabolic process	GO:0033240	0	0.697
cytoplasmic transport	GO:0016482	130	0.696
regulation of phosphorylation	GO:0042325	147	0.696
endocytosis	GO:0006897	310	0.694	Mouse Worm
meiotic spindle checkpoint	GO:0044779	1	0.693
regulation of cell migration	GO:0030334	22	0.692	Human
response to growth factor	GO:0070848	31	0.691
negative regulation of neurogenesis	GO:0050768	53	0.686
protein modification by small protein conjugation	GO:0032446	79	0.686
negative regulation of terminal cell fate specification open tracheal system	GO:0035155	2	0.677
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.673	Human Rat
regulation of mapk cascade	GO:0043408	92	0.669
positive regulation of rna metabolic process	GO:0051254	271	0.668	Human Yeast
catabolic process	GO:0009056	409	0.668
regulation of response to extracellular stimulus	GO:0032104	18	0.668
negative regulation of epithelial cell migration	GO:0010633	1	0.665
response to light stimulus	GO:0009416	124	0.664	Mouse
positive regulation of intracellular protein transport	GO:0090316	30	0.657
protein phosphorylation	GO:0006468	169	0.655	Human
regulation of synapse assembly	GO:0051963	94	0.654
positive regulation of transcription involved in g2 m transition of mitotic cell cycle	GO:0090282	1	0.653
protein targeting	GO:0006605	64	0.653
response to hormone	GO:0009725	45	0.648
intracellular protein transport	GO:0006886	104	0.647
canonical wnt signaling pathway	GO:0060070	21	0.636
positive regulation of r7 cell differentiation	GO:0045678	7	0.635
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.630
digestive tract development	GO:0048565	149	0.626
gland development	GO:0048732	191	0.624
immune system process	GO:0002376	347	0.619
specification of segmental identity antennal segment	GO:0007383	2	0.615
regulation of cell division	GO:0051302	72	0.615
cellular response to chemical stimulus	GO:0070887	199	0.612	Yeast
regulation of cell development	GO:0060284	215	0.610
glial cell development	GO:0021782	27	0.609
modification dependent protein catabolic process	GO:0019941	78	0.608
negative regulation of phosphorylation	GO:0042326	35	0.608	Fly
innate immune response	GO:0045087	144	0.605	Fly
negative regulation of phosphorus metabolic process	GO:0010563	45	0.605	Human Fly
negative regulation of programmed cell death	GO:0043069	72	0.605
regulation of synapse structure and activity	GO:0050803	128	0.599
oocyte construction	GO:0007308	112	0.595
negative regulation of response to extracellular stimulus	GO:0032105	6	0.593
regulation of cell projection organization	GO:0031344	92	0.592	Human Worm
mesoderm development	GO:0007498	78	0.586
response to insulin	GO:0032868	29	0.586
cellular protein modification process	GO:0006464	438	0.580	Human
establishment of organelle localization	GO:0051656	122	0.579
response to lipid	GO:0033993	38	0.575
negative regulation of dna templated transcription initiation	GO:2000143	1	0.571
negative regulation of rho gtpase activity	GO:0034259	1	0.568	Human
positive regulation of cell communication	GO:0010647	250	0.566
negative regulation of signal transduction	GO:0009968	206	0.564
secondary metabolic process	GO:0019748	75	0.561
positive regulation of growth	GO:0045927	75	0.558
positive regulation of cellular component biogenesis	GO:0044089	80	0.557	Human
dna templated transcriptional start site selection	GO:0001173	1	0.549
larval development	GO:0002164	104	0.546
embryo development ending in birth or egg hatching	GO:0009792	152	0.540	Zebrafish Worm
olfactory learning	GO:0008355	56	0.539
eye antennal disc development	GO:0035214	60	0.539
muscle cell differentiation	GO:0042692	103	0.539	Mouse
regulation of cell fate commitment	GO:0010453	29	0.536	Worm
regulation of ran gtpase activity	GO:0032316	1	0.532
protein localization	GO:0008104	284	0.529
positive regulation of catalytic activity	GO:0043085	118	0.527	Human Yeast Worm
cellular amine metabolic process	GO:0044106	12	0.525
digestive system development	GO:0055123	149	0.524
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.522
establishment or maintenance of polarity of larval imaginal disc epithelium	GO:0016336	3	0.521
positive regulation of ras protein signal transduction	GO:0046579	43	0.518	Mouse Rat
negative regulation of gtpase activity	GO:0034260	1	0.515	Human
positive regulation of ruffle assembly	GO:1900029	1	0.511	Human
dna integration	GO:0015074	1	0.510
positive regulation of rna biosynthetic process	GO:1902680	266	0.509	Human Yeast
wnt signaling pathway	GO:0016055	98	0.508
skin development	GO:0043588	65	0.508
negative regulation of ras gtpase activity	GO:0034261	1	0.506	Human
regulation of cellular localization	GO:0060341	136	0.504
organic substance catabolic process	GO:1901575	308	0.504
immune system development	GO:0002520	57	0.503
response to temperature stimulus	GO:0009266	106	0.497
response to uv	GO:0009411	24	0.494
skeletal muscle organ development	GO:0060538	48	0.491	Mouse
dormancy process	GO:0022611	2	0.487
purine nucleoside metabolic process	GO:0042278	127	0.486
maternal determination of dorsal ventral axis ovarian follicular epithelium germ line encoded	GO:0008070	2	0.485
positive regulation of cell death	GO:0010942	69	0.484
cellular response to oxygen containing compound	GO:1901701	79	0.484
inositol lipid mediated signaling	GO:0048017	4	0.482
stem cell proliferation	GO:0072089	88	0.482
peptidyl tyrosine modification	GO:0018212	24	0.482
neuron maturation	GO:0042551	31	0.481
proteolysis	GO:0006508	192	0.477
protein targeting to nucleus	GO:0044744	51	0.476
response to ethanol	GO:0045471	59	0.476
negative regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0017055	1	0.474
compound eye development	GO:0048749	307	0.473
olfactory behavior	GO:0042048	97	0.473
positive regulation of organelle organization	GO:0010638	65	0.470	Human
maintenance of location	GO:0051235	73	0.469
exocrine system development	GO:0035272	162	0.469
insulin receptor signaling pathway	GO:0008286	25	0.468
amine metabolic process	GO:0009308	12	0.468
organic cyclic compound catabolic process	GO:1901361	168	0.466
regulation of protein modification process	GO:0031399	112	0.464	Human
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.461
autophagic vacuole assembly	GO:0000045	2	0.460
establishment of tissue polarity	GO:0007164	87	0.460	Fly
guanosine containing compound metabolic process	GO:1901068	74	0.459
regulation of response to stress	GO:0080134	200	0.459
neuroblast proliferation	GO:0007405	74	0.458
asymmetric neuroblast division resulting in ganglion mother cell formation	GO:0055060	2	0.458
negative regulation of mrna 3 end processing	GO:0031441	3	0.452
single organism cellular localization	GO:1902580	180	0.451
single organism carbohydrate metabolic process	GO:0044723	72	0.448
regulation of cellular amine metabolic process	GO:0033238	3	0.446
regulation of cell proliferation	GO:0042127	163	0.445
purine ribonucleotide metabolic process	GO:0009150	145	0.440
anterior posterior axis specification	GO:0009948	109	0.438
release of cytoplasmic sequestered nf kappab	GO:0008588	1	0.438
neuron projection guidance	GO:0097485	241	0.436
cellular response to organonitrogen compound	GO:0071417	36	0.436
regulation of mitosis	GO:0007088	56	0.434
regulation of response to nutrient levels	GO:0032107	18	0.434
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.433
hindgut development	GO:0061525	58	0.433
response to drug	GO:0042493	17	0.432
mesenchymal cell differentiation	GO:0048762	1	0.431
regulation of cell cell adhesion	GO:0022407	21	0.431
neuromuscular synaptic transmission	GO:0007274	67	0.428
glial cell fate determination	GO:0007403	3	0.428
positive regulation of protein tyrosine kinase activity	GO:0061098	4	0.427
meiotic dna repair synthesis	GO:0000711	3	0.427
regulation of actin cytoskeleton organization	GO:0032956	42	0.426	Human
negative regulation of mitotic anaphase promoting complex activity	GO:0060564	2	0.425
melanin metabolic process	GO:0006582	47	0.421
negative regulation of cell death	GO:0060548	81	0.420
negative regulation of nucleoside metabolic process	GO:0045978	1	0.418	Human
regulation of cellular amino acid metabolic process	GO:0006521	0	0.418
positive regulation of hydrolase activity	GO:0051345	78	0.417	Human Worm
negative regulation of developmental process	GO:0051093	201	0.416
forebrain development	GO:0030900	2	0.412
negative regulation of protein metabolic process	GO:0051248	85	0.412
vesicle mediated transport	GO:0016192	381	0.412	Mouse Worm
respiratory system development	GO:0060541	213	0.410
response to red light	GO:0010114	2	0.409
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.408
regulation of localization	GO:0032879	275	0.407	Human Yeast
establishment of synaptic vesicle localization	GO:0097480	50	0.406
urogenital system development	GO:0001655	72	0.406
ameboidal type cell migration	GO:0001667	151	0.406
cell morphogenesis involved in malpighian tubule morphogenesis	GO:0061336	1	0.405
regulation of protein import into nucleus	GO:0042306	28	0.404
gastrulation	GO:0007369	70	0.401
anterior posterior axis specification follicular epithelium	GO:0030714	2	0.399
axonogenesis	GO:0007409	290	0.394
embryonic hindgut morphogenesis	GO:0048619	48	0.394
gonad development	GO:0008406	50	0.393	Worm
embryonic morphogenesis	GO:0048598	206	0.393
regulation of protein localization	GO:0032880	76	0.393	Yeast
response to endogenous stimulus	GO:0009719	119	0.380
p granule organization	GO:0030719	4	0.377
stress activated protein kinase signaling cascade	GO:0031098	55	0.376	Human Fly
negative regulation of response to stimulus	GO:0048585	258	0.373
negative regulation of gene expression	GO:0010629	387	0.368	Human
cell elongation involved in imaginal disc derived wing morphogenesis	GO:0090254	5	0.367
response to organic cyclic compound	GO:0014070	89	0.364
regulation of epithelial cell proliferation	GO:0050678	4	0.363	Human
ribonucleoside metabolic process	GO:0009119	127	0.362
epithelial cell proliferation	GO:0050673	15	0.360	Human
chromosome organization	GO:0051276	360	0.358
centripetally migrating follicle cell migration	GO:0060269	1	0.358
pigment metabolic process	GO:0042440	84	0.357
regulation of centriole centriole cohesion	GO:0030997	1	0.357
ganglion mother cell fate determination	GO:0007402	2	0.348
negative regulation of cellular biosynthetic process	GO:0031327	277	0.348
regulation of phosphatidylinositol 3 kinase activity	GO:0043551	2	0.347
negative regulation of nucleotide catabolic process	GO:0030812	1	0.346	Human
dorsal vessel heart proper cell fate commitment	GO:0035053	2	0.338
mesenchymal cell development	GO:0014031	1	0.338
positive regulation of cell proliferation	GO:0008284	47	0.337
cellular response to nitrogen compound	GO:1901699	51	0.336
purine ribonucleoside catabolic process	GO:0046130	112	0.334
cellular response to dna damage stimulus	GO:0006974	223	0.334
negative regulation of cellular protein metabolic process	GO:0032269	85	0.334
dorsal closure leading edge cell differentiation	GO:0046663	2	0.333
protein localization to organelle	GO:0033365	82	0.329
ribonucleotide metabolic process	GO:0009259	145	0.326
purine containing compound catabolic process	GO:0072523	112	0.319
heterocycle catabolic process	GO:0046700	166	0.319
regulation of extracellular matrix assembly	GO:1901201	1	0.318
regulation of intracellular transport	GO:0032386	64	0.318
peripheral nervous system development	GO:0007422	52	0.317
associative learning	GO:0008306	65	0.316	Mouse

Ras85D disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
cancer	DOID:162	0.742	Human
disease of cellular proliferation	DOID:14566	0.742	Human
thyroid carcinoma	DOID:3963	0.718	Human
endocrine gland cancer	DOID:170	0.718	Human
thyroid cancer	DOID:1781	0.718	Human
organ system cancer	DOID:0050686	0.718	Human
follicular thyroid carcinoma	DOID:3962	0.718	Human
organ system benign neoplasm	DOID:0060085	0.619
pilomatrixoma	DOID:5374	0.619
hair follicle neoplasm	DOID:5375	0.619
benign neoplasm	DOID:0060072	0.619
skin benign neoplasm	DOID:3165	0.619
integumentary system benign neoplasm	DOID:0060121	0.619
hajdu cheney syndrome	DOID:2736	0.575
artery disease	DOID:0050828	0.495
disease of anatomical entity	DOID:7	0.495
vascular disease	DOID:178	0.495
cardiovascular system disease	DOID:1287	0.495
aortic disease	DOID:520	0.495
pancreatic carcinoma	DOID:4905	0.445	Human
pancreatic cancer	DOID:1793	0.445	Human
urinary bladder cancer	DOID:11054	0.442	Human
urinary system cancer	DOID:3996	0.442	Human
disease of metabolism	DOID:0014667	0.419
hemochromatosis	DOID:2352	0.419
inherited metabolic disorder	DOID:655	0.419
metal metabolism disorder	DOID:896	0.419
nervous system benign neoplasm	DOID:0060115	0.371
costello syndrome	DOID:0050469	0.350	Human

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