IMP: Integrative Multi-species Prediction

Drosophila melanogaster

134 known processes

gro (Dmel_CG8384)

groucho

(Aliases: anon-WO0118547.385,m10,DGro,GRO,Gro,E(spl)-WD,BcDNA:LD33829,Grg/TLE,BcDNA.LD33829,E(spl)gro,m9,E(spl)m9/m10,dAES2,BEST:GM01575,dAES1,E(spl)[2],CG8384,l(3)gro,En-spl,m9/10,m9/m10,m9-m10,Dmel\CG8384,dGro,BEST:LD15161)

FLYBASE: FBgn0001139
Entrez: 43162
UniProtKB: P16371

Process Predictions
Disease Predictions

gro biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of rna metabolic process	GO:0051253	251	1.000
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.997
cell proliferation	GO:0008283	299	0.995
negative regulation of developmental process	GO:0051093	201	0.995
positive regulation of biosynthetic process	GO:0009891	316	0.993
positive regulation of transcription dna templated	GO:0045893	266	0.990
positive regulation of macromolecule metabolic process	GO:0010604	405	0.980	Human
stem cell maintenance	GO:0019827	67	0.972
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.970
muscle structure development	GO:0061061	224	0.969
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.968
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.961
negative regulation of cell cycle	GO:0045786	116	0.961
regulation of cell differentiation	GO:0045595	302	0.960	Worm
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.958
muscle organ development	GO:0007517	127	0.954
negative regulation of transcription dna templated	GO:0045892	237	0.947
dendrite morphogenesis	GO:0048813	199	0.943
positive regulation of rna metabolic process	GO:0051254	271	0.940
negative regulation of biosynthetic process	GO:0009890	277	0.933
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.932
protein modification process	GO:0036211	438	0.930
positive regulation of cellular biosynthetic process	GO:0031328	316	0.925
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.918
regulation of cell proliferation	GO:0042127	163	0.910
negative regulation of mitotic cell cycle	GO:0045930	109	0.907
stem cell differentiation	GO:0048863	117	0.903
regulation of cell development	GO:0060284	215	0.896	Worm
chromatin modification	GO:0016568	147	0.878
male gamete generation	GO:0048232	201	0.869
negative regulation of cell cycle process	GO:0010948	109	0.851
negative regulation of gene expression	GO:0010629	387	0.847
stem cell proliferation	GO:0072089	88	0.838
endodermal cell differentiation	GO:0035987	3	0.835
histone modification	GO:0016570	106	0.834
protein modification by small protein conjugation or removal	GO:0070647	106	0.829
spermatogenesis	GO:0007283	200	0.829
negative regulation of cellular biosynthetic process	GO:0031327	277	0.828
regulation of cell cycle phase transition	GO:1901987	130	0.827
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.812
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.807
cell division	GO:0051301	248	0.796
dna metabolic process	GO:0006259	227	0.778
small molecule metabolic process	GO:0044281	305	0.774	Zebrafish
regulation of mitotic cell cycle	GO:0007346	190	0.764
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.756
dendrite development	GO:0016358	204	0.753
regulation of neuron differentiation	GO:0045664	103	0.734	Worm
negative regulation of cell cycle phase transition	GO:1901988	103	0.733
establishment of localization in cell	GO:0051649	402	0.724	Worm
sensory organ morphogenesis	GO:0090596	260	0.724
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.708
negative regulation of cell differentiation	GO:0045596	143	0.706
regulation of nervous system development	GO:0051960	248	0.693	Worm
regulation of phosphorylation	GO:0042325	147	0.689
regulation of multicellular organismal development	GO:2000026	414	0.684	Worm
regulation of neuroblast proliferation	GO:1902692	34	0.675
positive regulation of response to stimulus	GO:0048584	323	0.674
positive regulation of cell proliferation	GO:0008284	47	0.668
eye development	GO:0001654	323	0.658
negative regulation of cell communication	GO:0010648	223	0.646
tube development	GO:0035295	244	0.645
cellular protein modification process	GO:0006464	438	0.619
neuron projection guidance	GO:0097485	241	0.619
tissue morphogenesis	GO:0048729	297	0.616
regionalization	GO:0003002	416	0.596
post embryonic appendage morphogenesis	GO:0035120	385	0.592
body morphogenesis	GO:0010171	2	0.591
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.589
organonitrogen compound metabolic process	GO:1901564	318	0.575
regulation of protein modification process	GO:0031399	112	0.572
positive regulation of rna biosynthetic process	GO:1902680	266	0.568
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.558
dna repair	GO:0006281	54	0.554
r7 cell differentiation	GO:0045466	43	0.553
positive regulation of cell death	GO:0010942	69	0.550
positive regulation of gene expression	GO:0010628	290	0.546	Human
connective tissue development	GO:0061448	3	0.541
axon guidance	GO:0007411	233	0.538
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.538
cell fate specification	GO:0001708	71	0.537
cellular macromolecule localization	GO:0070727	220	0.537
cell death	GO:0008219	279	0.534	Human
positive regulation of nervous system development	GO:0051962	69	0.533
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.529
neuroblast proliferation	GO:0007405	74	0.525
regulation of cell cycle	GO:0051726	291	0.523
forebrain development	GO:0030900	2	0.521
protein ubiquitination	GO:0016567	70	0.518
negative regulation of signaling	GO:0023057	219	0.509
protein localization	GO:0008104	284	0.508
regulation of protein metabolic process	GO:0051246	256	0.501
organelle fission	GO:0048285	340	0.494
regulation of stem cell proliferation	GO:0072091	40	0.493
multi organism reproductive behavior	GO:0044705	121	0.481
regulation of cell cycle process	GO:0010564	181	0.481
circulatory system development	GO:0072359	82	0.480
regulation of transport	GO:0051049	181	0.480
protein complex assembly	GO:0006461	200	0.466
regulation of cellular protein metabolic process	GO:0032268	243	0.461
appendage morphogenesis	GO:0035107	397	0.461
notch signaling pathway	GO:0007219	120	0.457
ectodermal placode formation	GO:0060788	4	0.450
morphogenesis of an epithelium	GO:0002009	276	0.448
wing disc morphogenesis	GO:0007472	344	0.432
regulation of intracellular protein transport	GO:0033157	46	0.424
camera type eye development	GO:0043010	4	0.410
central nervous system development	GO:0007417	201	0.376
positive regulation of multicellular organismal process	GO:0051240	143	0.375
appendage development	GO:0048736	401	0.372
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.368
single organism behavior	GO:0044708	391	0.353
apoptotic process	GO:0006915	159	0.350	Human
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	9	0.348
imaginal disc derived appendage development	GO:0048737	399	0.345
eye morphogenesis	GO:0048592	260	0.344
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.338
positive regulation of protein metabolic process	GO:0051247	128	0.337
regulation of cell death	GO:0010941	173	0.328	Human
multicellular organismal reproductive behavior	GO:0033057	110	0.325
negative regulation of wnt signaling pathway	GO:0030178	28	0.320
digestive system development	GO:0055123	149	0.316
heart morphogenesis	GO:0003007	32	0.315
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.313
somatic stem cell maintenance	GO:0035019	14	0.312
regulation of bmp signaling pathway	GO:0030510	23	0.311
meiotic nuclear division	GO:0007126	151	0.309
chromosome organization	GO:0051276	360	0.307
retina development in camera type eye	GO:0060041	4	0.307
localization of cell	GO:0051674	257	0.306
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.303
regulation of molecular function	GO:0065009	217	0.297
endodermal cell fate commitment	GO:0001711	3	0.297
cellular response to dna damage stimulus	GO:0006974	223	0.282
negative regulation of response to stimulus	GO:0048585	258	0.280
bmp signaling pathway	GO:0030509	27	0.280
negative regulation of neurogenesis	GO:0050768	53	0.260
digestive tract development	GO:0048565	149	0.256
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.255
nuclear transport	GO:0051169	72	0.247
positive regulation of developmental process	GO:0051094	143	0.247
developmental growth	GO:0048589	280	0.245
neural precursor cell proliferation	GO:0061351	75	0.242
regulation of notch signaling pathway	GO:0008593	100	0.238
embryonic morphogenesis	GO:0048598	206	0.236
imaginal disc derived wing vein specification	GO:0007474	48	0.233
response to organic substance	GO:0010033	284	0.233
retinal ganglion cell axon guidance	GO:0031290	12	0.228
regulation of gene expression epigenetic	GO:0040029	128	0.216
negative regulation of signal transduction	GO:0009968	206	0.214
cell fate determination	GO:0001709	91	0.214
regulation of heart morphogenesis	GO:2000826	3	0.214
negative regulation of cell development	GO:0010721	62	0.209
positive regulation of cell development	GO:0010720	61	0.203
peptidyl amino acid modification	GO:0018193	105	0.203
camera type eye morphogenesis	GO:0048593	2	0.202
stem cell development	GO:0048864	79	0.193
transcription from rna polymerase ii promoter	GO:0006366	368	0.191
regulation of organelle organization	GO:0033043	196	0.184
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.183
regulation of dna metabolic process	GO:0051052	34	0.177
regulation of neural precursor cell proliferation	GO:2000177	35	0.175
regulation of localization	GO:0032879	275	0.174
skeletal muscle organ development	GO:0060538	48	0.166
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.165
regulation of stem cell differentiation	GO:2000736	14	0.164
heart development	GO:0007507	82	0.163
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.161
peripheral nervous system development	GO:0007422	52	0.159
anatomical structure homeostasis	GO:0060249	97	0.158
cell motility	GO:0048870	251	0.154
death	GO:0016265	284	0.147	Human
compound eye development	GO:0048749	307	0.147
positive regulation of protein modification process	GO:0031401	58	0.145
positive regulation of cell differentiation	GO:0045597	64	0.144
positive regulation of bmp signaling pathway	GO:0030513	5	0.143
regulation of organ formation	GO:0003156	3	0.142
covalent chromatin modification	GO:0016569	106	0.142
embryonic organ development	GO:0048568	50	0.140
positive regulation of signal transduction	GO:0009967	223	0.135
negative regulation of cellular metabolic process	GO:0031324	382	0.134
regulation of cellular localization	GO:0060341	136	0.133
protein localization to nucleus	GO:0034504	55	0.132
response to endogenous stimulus	GO:0009719	119	0.126
gonad development	GO:0008406	50	0.126	Worm
negative regulation of nervous system development	GO:0051961	92	0.125
immune system process	GO:0002376	347	0.124	Zebrafish
wing disc pattern formation	GO:0035222	66	0.123
muscle tissue development	GO:0060537	30	0.123
nephron tubule morphogenesis	GO:0072078	3	0.121
epithelial cell development	GO:0002064	274	0.120
spinal cord development	GO:0021510	1	0.120
regulation of cellular amino acid metabolic process	GO:0006521	0	0.120
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.120
neuron fate commitment	GO:0048663	50	0.117
positive regulation of neuron differentiation	GO:0045666	26	0.117
hindbrain development	GO:0030902	2	0.115
myotube differentiation	GO:0014902	46	0.115
nucleus organization	GO:0006997	45	0.113
nephron epithelium morphogenesis	GO:0072088	3	0.113
genitalia development	GO:0048806	26	0.111	Worm
regulation of phosphorus metabolic process	GO:0051174	210	0.109
axon development	GO:0061564	297	0.108	Worm
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	11	0.108
wnt signaling pathway	GO:0016055	98	0.108
regulation of response to stress	GO:0080134	200	0.107
positive regulation of cellular protein metabolic process	GO:0032270	118	0.105
organic substance transport	GO:0071702	257	0.104
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	6	0.104
mrna metabolic process	GO:0016071	124	0.104
negative regulation of multicellular organismal process	GO:0051241	142	0.103
cellular protein localization	GO:0034613	160	0.103
taxis	GO:0042330	304	0.103
positive regulation of apoptotic process	GO:0043065	47	0.103
cytoplasmic microtubule organization	GO:0031122	22	0.102
epithelial cell differentiation	GO:0030855	322	0.099
mesoderm development	GO:0007498	78	0.096
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.092
regulation of protein transport	GO:0051223	57	0.092
positive regulation of cell communication	GO:0010647	250	0.089
amine metabolic process	GO:0009308	12	0.089
epidermis development	GO:0008544	65	0.088
mesenchymal cell differentiation	GO:0048762	1	0.084
endocytosis	GO:0006897	310	0.084
imaginal disc growth	GO:0007446	37	0.083
nephron tubule development	GO:0072080	3	0.081
sister chromatid segregation	GO:0000819	92	0.081
retina morphogenesis in camera type eye	GO:0060042	2	0.081
protein transport	GO:0015031	155	0.079
regulation of neurogenesis	GO:0050767	158	0.077	Worm
head development	GO:0060322	135	0.077
imaginal disc derived wing morphogenesis	GO:0007476	337	0.076
kidney development	GO:0001822	3	0.075
protein complex biogenesis	GO:0070271	201	0.074
cellular amine metabolic process	GO:0044106	12	0.074
cell cycle checkpoint	GO:0000075	95	0.074
embryonic organ morphogenesis	GO:0048562	5	0.074
cellular response to chemical stimulus	GO:0070887	199	0.073
chromatin remodeling	GO:0006338	72	0.073
negative regulation of rna biosynthetic process	GO:1902679	240	0.072
proteolysis	GO:0006508	192	0.071
mitotic dna integrity checkpoint	GO:0044774	75	0.071
nephron epithelium development	GO:0072009	3	0.069
reproductive system development	GO:0061458	74	0.068	Worm
positive regulation of protein import into nucleus translocation	GO:0033160	2	0.068
protein modification by small protein conjugation	GO:0032446	79	0.068
regulation of cell projection organization	GO:0031344	92	0.068	Worm
intracellular protein transport	GO:0006886	104	0.068
cell type specific apoptotic process	GO:0097285	38	0.067
defense response	GO:0006952	300	0.066
cardiovascular system development	GO:0072358	82	0.066
eye antennal disc development	GO:0035214	60	0.065
mushroom body development	GO:0016319	70	0.064
negative regulation of neural precursor cell proliferation	GO:2000178	27	0.064
growth	GO:0040007	359	0.063
mitotic cell cycle checkpoint	GO:0007093	88	0.061
single organism catabolic process	GO:0044712	228	0.061
sex differentiation	GO:0007548	81	0.061	Worm
positive regulation of cellular component organization	GO:0051130	156	0.060
protein targeting	GO:0006605	64	0.060
nucleoside triphosphate metabolic process	GO:0009141	120	0.059
anterior posterior pattern specification	GO:0009952	136	0.059
response to organic cyclic compound	GO:0014070	89	0.059
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	4	0.059
sex determination	GO:0007530	18	0.059
mitotic cell cycle phase transition	GO:0044772	138	0.058
morphogenesis of embryonic epithelium	GO:0016331	94	0.058
regulation of protein localization	GO:0032880	76	0.057
positive regulation of stem cell differentiation	GO:2000738	3	0.057
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.056
protein import into nucleus	GO:0006606	51	0.055
embryo development ending in birth or egg hatching	GO:0009792	152	0.055	Worm
dna methylation or demethylation	GO:0044728	4	0.055
phosphorylation	GO:0016310	294	0.055
carbohydrate derivative metabolic process	GO:1901135	217	0.055
gastrulation	GO:0007369	70	0.054
organic substance catabolic process	GO:1901575	308	0.054
mesenchymal cell development	GO:0014031	1	0.053
regulation of programmed cell death	GO:0043067	152	0.053	Human
neuroblast division	GO:0055057	35	0.052
positive regulation of molecular function	GO:0044093	136	0.052
neurological system process	GO:0050877	358	0.052
organ growth	GO:0035265	56	0.052
positive regulation of signaling	GO:0023056	243	0.051
regulation of neuron projection development	GO:0010975	69	0.050	Worm
formation of primary germ layer	GO:0001704	24	0.048
negative regulation of notch signaling pathway	GO:0045746	41	0.048
positive regulation of neurogenesis	GO:0050769	41	0.047
axis specification	GO:0009798	167	0.047
stress granule disassembly	GO:0035617	1	0.047
muscle cell differentiation	GO:0042692	103	0.047
gliogenesis	GO:0042063	80	0.046
regulation of immune system process	GO:0002682	176	0.045
regulation of hematopoietic progenitor cell differentiation	GO:1901532	1	0.044
regulation of chromosome organization	GO:0033044	64	0.043
blastoderm segmentation	GO:0007350	159	0.042
cellular amino acid metabolic process	GO:0006520	61	0.041
central nervous system neuron differentiation	GO:0021953	8	0.041
regulation of glial cell differentiation	GO:0045685	1	0.040
nuclear import	GO:0051170	51	0.040
negative regulation of cell proliferation	GO:0008285	69	0.040
cell migration	GO:0016477	238	0.040
reproductive structure development	GO:0048608	74	0.040	Worm
smoothened signaling pathway	GO:0007224	49	0.039
meiotic cell cycle process	GO:1903046	132	0.039
tube morphogenesis	GO:0035239	191	0.038
chromatin organization	GO:0006325	207	0.038
regulation of phosphate metabolic process	GO:0019220	210	0.038
regulation of dendrite morphogenesis	GO:0048814	28	0.038
negative regulation of molecular function	GO:0044092	51	0.037
telencephalon development	GO:0021537	2	0.037
chromosome segregation	GO:0007059	157	0.037
regulation of tyrosine phosphorylation of stat protein	GO:0042509	1	0.037
neuron recognition	GO:0008038	101	0.037
regulation of imaginal disc growth	GO:0045570	26	0.036
establishment of protein localization	GO:0045184	163	0.036
regulation of apoptotic process	GO:0042981	130	0.036	Human
regulation of transferase activity	GO:0051338	58	0.036
secretion	GO:0046903	109	0.035
negative regulation of phosphatase activity	GO:0010923	3	0.035
mitotic nuclear division	GO:0007067	213	0.035
asymmetric cell division	GO:0008356	37	0.035
spermatid differentiation	GO:0048515	114	0.035
cell cycle phase transition	GO:0044770	140	0.034
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.034
regulation of cellular response to stress	GO:0080135	89	0.033
muscle cell fate commitment	GO:0042693	14	0.033
regulation of cell morphogenesis	GO:0022604	163	0.033	Worm
nucleocytoplasmic transport	GO:0006913	72	0.032
skeletal muscle tissue development	GO:0007519	13	0.032
mitotic spindle organization	GO:0007052	220	0.032
myoblast fusion	GO:0007520	43	0.031
oocyte morphogenesis	GO:0048601	3	0.031
striated muscle tissue development	GO:0014706	27	0.031
intracellular transport	GO:0046907	228	0.031
intracellular signal transduction	GO:0035556	300	0.030	Human
digestive tract morphogenesis	GO:0048546	127	0.030
equator specification	GO:0045317	4	0.030
signal transduction downstream of smoothened	GO:0007227	5	0.030
locomotory behavior	GO:0007626	176	0.030
activation of jun kinase activity	GO:0007257	3	0.029
nephron development	GO:0072006	3	0.029
g1 s transition of mitotic cell cycle	GO:0000082	31	0.029
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.029
glial cell differentiation	GO:0010001	35	0.028
dna alkylation	GO:0006305	4	0.028
regulation of wnt signaling pathway	GO:0030111	68	0.028
regulation of phosphatase activity	GO:0010921	3	0.027
nuclear division	GO:0000280	332	0.027
eggshell chorion assembly	GO:0007306	66	0.027
kidney epithelium development	GO:0072073	3	0.027
regulation of kinase activity	GO:0043549	53	0.027
vesicle mediated transport	GO:0016192	381	0.027
axonogenesis	GO:0007409	290	0.026	Worm
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.026
neural retina development	GO:0003407	4	0.026
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.026
protein targeting to nucleus	GO:0044744	51	0.026
negative regulation of programmed cell death	GO:0043069	72	0.025	Human
open tracheal system development	GO:0007424	204	0.025
phagocytosis	GO:0006909	215	0.025
response to wounding	GO:0009611	94	0.025
hematopoietic progenitor cell differentiation	GO:0002244	1	0.025
establishment of spindle localization	GO:0051293	22	0.025
positive regulation of transport	GO:0051050	92	0.025
mrna processing	GO:0006397	104	0.025
regulation of anatomical structure morphogenesis	GO:0022603	242	0.025	Worm
developmental maturation	GO:0021700	172	0.025
aging	GO:0007568	143	0.024
ectodermal placode development	GO:0071696	4	0.024
cellular component assembly involved in morphogenesis	GO:0010927	151	0.024
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.024
positive regulation of notch signaling pathway	GO:0045747	34	0.024
midgut development	GO:0007494	23	0.024
regulation of cellular amine metabolic process	GO:0033238	3	0.024
meiotic cell cycle	GO:0051321	171	0.024
brain development	GO:0007420	120	0.024
intrinsic apoptotic signaling pathway	GO:0097193	16	0.023
regulation of neuron death	GO:1901214	26	0.023
regulation of establishment of protein localization	GO:0070201	61	0.023
cellular response to organic substance	GO:0071310	132	0.023
dorsal ventral pattern formation	GO:0009953	133	0.023
adult behavior	GO:0030534	137	0.023
meiotic nuclear envelope disassembly	GO:0051078	2	0.023
kidney morphogenesis	GO:0060993	3	0.023
mitotic dna damage checkpoint	GO:0044773	74	0.023
regulation of atp catabolic process	GO:1903289	4	0.022
establishment of tissue polarity	GO:0007164	87	0.022
mitotic g2 dna damage checkpoint	GO:0007095	69	0.022
positive regulation of cell cycle	GO:0045787	43	0.022
cellular protein complex assembly	GO:0043623	71	0.021
hemopoiesis	GO:0030097	46	0.021	Zebrafish
establishment of mitotic spindle localization	GO:0040001	17	0.021
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.021
photoreceptor cell fate commitment	GO:0046552	41	0.021
regulation of epithelial cell differentiation	GO:0030856	4	0.021
positive regulation of developmental growth	GO:0048639	62	0.020
determination of dorsal ventral asymmetry	GO:0048262	3	0.020
response to abiotic stimulus	GO:0009628	341	0.020
dendrite regeneration	GO:0031104	2	0.020
developmental programmed cell death	GO:0010623	138	0.020
regulation of protein serine threonine kinase activity	GO:0071900	25	0.020
anterior head segmentation	GO:0035288	3	0.020
single organism nuclear import	GO:1902593	51	0.019
pigment cell differentiation	GO:0050931	3	0.019
regulation of cell proliferation involved in compound eye morphogenesis	GO:2000495	2	0.019
ribonucleoprotein complex disassembly	GO:0032988	1	0.019
regulation of intracellular transport	GO:0032386	64	0.019
actin filament organization	GO:0007015	126	0.019
epithelial tube morphogenesis	GO:0060562	88	0.019
cytoplasmic transport	GO:0016482	130	0.019
positive regulation of cell maturation	GO:1903431	2	0.019
single organism cellular localization	GO:1902580	180	0.019
unsaturated fatty acid biosynthetic process	GO:0006636	1	0.019
cell cycle arrest	GO:0007050	4	0.018
immune response	GO:0006955	246	0.018
imaginal disc pattern formation	GO:0007447	91	0.018
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded	GO:0008071	1	0.018
regulation of hydrolase activity	GO:0051336	97	0.018
signal transduction by phosphorylation	GO:0023014	107	0.017
compound eye morphogenesis	GO:0001745	249	0.017
carboxylic acid metabolic process	GO:0019752	92	0.017	Zebrafish
oocyte fate commitment	GO:0048600	2	0.017
single organism intracellular transport	GO:1902582	207	0.017
cellular ketone metabolic process	GO:0042180	24	0.017	Zebrafish
dorsal ventral axis specification	GO:0009950	66	0.017
germ line stem cell maintenance	GO:0030718	50	0.017
regulation of catabolic process	GO:0009894	170	0.017
regulation of organ morphogenesis	GO:2000027	78	0.017
negative regulation of neuron differentiation	GO:0045665	16	0.017
mrna splicing via spliceosome	GO:0000398	73	0.017
meiotic spindle checkpoint	GO:0044779	1	0.017
rac protein signal transduction	GO:0016601	3	0.017
positive regulation of neural precursor cell proliferation	GO:2000179	8	0.017
epithelial cell migration	GO:0010631	148	0.016
small gtpase mediated signal transduction	GO:0007264	88	0.016
multicellular organism growth	GO:0035264	46	0.016
glial cell fate commitment	GO:0021781	3	0.016
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.016
catabolic process	GO:0009056	409	0.016
cell fate commitment involved in pattern specification	GO:0060581	31	0.016
positive regulation of chromatin silencing at telomere	GO:0031940	2	0.016
regulation of planar cell polarity pathway involved in axis elongation	GO:2000040	2	0.016
ribose phosphate metabolic process	GO:0019693	145	0.015
regulation of cellular catabolic process	GO:0031329	157	0.015
larval development	GO:0002164	104	0.015	Worm
spinal cord dorsal ventral patterning	GO:0021513	1	0.015
protein phosphorylation	GO:0006468	169	0.015
regulation of sequence specific dna binding transcription factor activity	GO:0051090	12	0.015
columnar cuboidal epithelial cell development	GO:0002066	249	0.015
regulation of cellular ketone metabolic process	GO:0010565	3	0.015	Zebrafish
anterior posterior pattern specification imaginal disc	GO:0007448	16	0.015
regulation of catalytic activity	GO:0050790	185	0.015
negative regulation of smoothened signaling pathway	GO:0045879	16	0.015
activation of ral gtpase activity	GO:0032859	1	0.015
nucleoside metabolic process	GO:0009116	127	0.015
neuronal stem cell maintenance	GO:0097150	4	0.014
r3 r4 cell fate commitment	GO:0007464	10	0.014
regulation of dendrite development	GO:0050773	37	0.014
regulation of nucleocytoplasmic transport	GO:0046822	35	0.014
positive regulation of golgi to plasma membrane protein transport	GO:0042998	2	0.014
cardiocyte differentiation	GO:0035051	29	0.014
hindgut morphogenesis	GO:0007442	58	0.014
programmed cell death	GO:0012501	257	0.014	Human
sensory neuron axon guidance	GO:0097374	2	0.014
positive regulation of endopeptidase activity	GO:0010950	26	0.014
wing disc dorsal ventral pattern formation	GO:0048190	47	0.014
renal system development	GO:0072001	72	0.013
r1 r6 cell differentiation	GO:0048052	4	0.013
epidermis morphogenesis	GO:0048730	5	0.013
neuronal stem cell division	GO:0036445	35	0.013
regulation of dna templated transcription elongation	GO:0032784	17	0.013
microtubule sliding	GO:0051012	3	0.013
regulation of hematopoietic stem cell differentiation	GO:1902036	1	0.013
organelle inheritance	GO:0048308	2	0.013
cell cycle g1 s phase transition	GO:0044843	31	0.013
regulation of mrna splicing via spliceosome	GO:0048024	64	0.013
cellular response to endogenous stimulus	GO:0071495	80	0.013
muscle cell fate specification	GO:0042694	7	0.013
negative regulation of immune system process	GO:0002683	50	0.013
regulation of protein modification by small protein conjugation or removal	GO:1903320	25	0.013
regulation of cell fate commitment	GO:0010453	29	0.013
organic acid metabolic process	GO:0006082	103	0.012	Zebrafish
positive regulation of catalytic activity	GO:0043085	118	0.012
macromolecule deacylation	GO:0098732	11	0.012
regulation of chromatin modification	GO:1903308	28	0.012
regulation of jak stat cascade	GO:0046425	43	0.012
positive regulation of neuroblast proliferation	GO:0002052	7	0.012
posttranscriptional gene silencing by rna	GO:0035194	45	0.012

gro disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.122
musculoskeletal system disease	DOID:17	0.110
disease of cellular proliferation	DOID:14566	0.073
cancer	DOID:162	0.073
organ system cancer	DOID:0050686	0.073
bone disease	DOID:0080001	0.019
connective tissue disease	DOID:65	0.019
head and neck cancer	DOID:11934	0.012
nervous system disease	DOID:863	0.012

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