IMP: Integrative Multi-species Prediction

Drosophila melanogaster

2 known processes

alpha-Est5 (Dmel_CG1089)

alpha-Esterase-5

(Aliases: EST-C,aE5,D,ESTC,DmalphaE5,Est-c,CG1089,Est-C,alphaE5,Est-9,EST9,Dmel\CG1089)

Entrez: 40905
FLYBASE: FBgn0261393
UniProtKB: Q95U30

Process Predictions
Disease Predictions

alpha-Est5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
post embryonic appendage morphogenesis	GO:0035120	385	0.153
imaginal disc derived appendage development	GO:0048737	399	0.108
wing disc morphogenesis	GO:0007472	344	0.108
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.105
appendage morphogenesis	GO:0035107	397	0.102
imaginal disc derived wing morphogenesis	GO:0007476	337	0.101
small molecule metabolic process	GO:0044281	305	0.095
defense response	GO:0006952	300	0.081
appendage development	GO:0048736	401	0.076
neurotransmitter metabolic process	GO:0042133	2	0.075
organonitrogen compound metabolic process	GO:1901564	318	0.072
response to other organism	GO:0051707	293	0.063
ethanolamine containing compound metabolic process	GO:0042439	4	0.063
chemotaxis	GO:0006935	249	0.060
catabolic process	GO:0009056	409	0.058
establishment of localization in cell	GO:0051649	402	0.057
cellular catabolic process	GO:0044248	372	0.052
response to external biotic stimulus	GO:0043207	293	0.052
response to organic substance	GO:0010033	284	0.051
neuron projection guidance	GO:0097485	241	0.050
axon guidance	GO:0007411	233	0.050
choline metabolic process	GO:0019695	1	0.048
axonogenesis	GO:0007409	290	0.047
single organism biosynthetic process	GO:0044711	206	0.046
taxis	GO:0042330	304	0.046
response to monosaccharide	GO:0034284	4	0.046
single organism catabolic process	GO:0044712	228	0.046
response to abiotic stimulus	GO:0009628	341	0.046
epithelial cell development	GO:0002064	274	0.045
cellular amino acid metabolic process	GO:0006520	61	0.044
organic substance catabolic process	GO:1901575	308	0.044
motor neuron axon guidance	GO:0008045	58	0.044
organic substance transport	GO:0071702	257	0.043
neuron recognition	GO:0008038	101	0.043
columnar cuboidal epithelial cell development	GO:0002066	249	0.043
carboxylic acid metabolic process	GO:0019752	92	0.042
acetate ester metabolic process	GO:1900619	2	0.042
cellular amine metabolic process	GO:0044106	12	0.041
ovarian follicle cell development	GO:0030707	248	0.041
organic acid metabolic process	GO:0006082	103	0.041
amine catabolic process	GO:0009310	1	0.040
amine metabolic process	GO:0009308	12	0.040
oxoacid metabolic process	GO:0043436	103	0.039
acetylcholine catabolic process	GO:0006581	1	0.038
synaptic transmission	GO:0007268	288	0.038
synaptic target recognition	GO:0008039	45	0.038
defense response to other organism	GO:0098542	225	0.037
response to oxygen containing compound	GO:1901700	200	0.036
lateral inhibition	GO:0046331	206	0.036
ameboidal type cell migration	GO:0001667	151	0.035
acetylcholine metabolic process	GO:0008291	2	0.035
epithelial cell differentiation	GO:0030855	322	0.034
phagocytosis	GO:0006909	215	0.034
regulation of cellular ketone metabolic process	GO:0010565	3	0.034
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.033
secondary metabolic process	GO:0019748	75	0.033
immune system process	GO:0002376	347	0.033
neurotransmitter catabolic process	GO:0042135	1	0.033
single organism behavior	GO:0044708	391	0.032
pigment metabolic process	GO:0042440	84	0.032
respiratory system development	GO:0060541	213	0.031
vesicle mediated transport	GO:0016192	381	0.031
organelle fission	GO:0048285	340	0.031
response to organophosphorus	GO:0046683	2	0.031
melanotic encapsulation of foreign target	GO:0035011	30	0.031
anion homeostasis	GO:0055081	3	0.030
choline catabolic process	GO:0042426	1	0.030
localization of cell	GO:0051674	257	0.029
protein transmembrane transport	GO:0071806	4	0.029
protein modification process	GO:0036211	438	0.029
positive regulation of macromolecule metabolic process	GO:0010604	405	0.029
organophosphate metabolic process	GO:0019637	195	0.029
tissue migration	GO:0090130	155	0.029
male mating behavior	GO:0060179	70	0.028
chromosome segregation	GO:0007059	157	0.028
cellular ketone metabolic process	GO:0042180	24	0.028
nucleobase containing small molecule metabolic process	GO:0055086	174	0.028
cellular protein modification process	GO:0006464	438	0.028
response to light stimulus	GO:0009416	124	0.028
non sensory hair organization	GO:0035316	47	0.028
intracellular transport	GO:0046907	228	0.027
determination of adult lifespan	GO:0008340	137	0.027
epithelial cell migration	GO:0010631	148	0.027
cell motility	GO:0048870	251	0.026
cellular biogenic amine catabolic process	GO:0042402	1	0.026
carbohydrate derivative metabolic process	GO:1901135	217	0.026
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.026
nuclear division	GO:0000280	332	0.026
cell migration	GO:0016477	238	0.026
border follicle cell migration	GO:0007298	113	0.025
female meiosis chromosome segregation	GO:0016321	33	0.025
organic hydroxy compound metabolic process	GO:1901615	83	0.025
response to glucose	GO:0009749	2	0.025
steroid catabolic process	GO:0006706	1	0.025
positive regulation of cellular biosynthetic process	GO:0031328	316	0.025
open tracheal system development	GO:0007424	204	0.025
cell recognition	GO:0008037	102	0.024
regulation of localization	GO:0032879	275	0.024
axon development	GO:0061564	297	0.024
response to radiation	GO:0009314	155	0.024
endocytosis	GO:0006897	310	0.024
secretion by cell	GO:0032940	101	0.024
melanin metabolic process	GO:0006582	47	0.023
multicellular organismal aging	GO:0010259	140	0.023
carbohydrate metabolic process	GO:0005975	82	0.023
xenobiotic catabolic process	GO:0042178	1	0.023
response to lipopolysaccharide	GO:0032496	4	0.023
cell death	GO:0008219	279	0.023
pyridine containing compound metabolic process	GO:0072524	3	0.023
epithelium migration	GO:0090132	148	0.023
melanization defense response	GO:0035006	45	0.022
spermatogenesis	GO:0007283	200	0.022
imaginal disc derived wing hair organization	GO:0035317	45	0.022
response to hexose	GO:0009746	3	0.021
telencephalon development	GO:0021537	2	0.021
phospholipid homeostasis	GO:0055091	1	0.021
oxidoreduction coenzyme metabolic process	GO:0006733	2	0.021
acylglycerol biosynthetic process	GO:0046463	2	0.021
response to temperature stimulus	GO:0009266	106	0.021
positive regulation of signaling	GO:0023056	243	0.020
regionalization	GO:0003002	416	0.020
regulation of cell cycle	GO:0051726	291	0.020
nucleoside phosphate metabolic process	GO:0006753	162	0.020
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.020
negative regulation of cellular metabolic process	GO:0031324	382	0.020
regulation of anatomical structure size	GO:0090066	163	0.020
positive regulation of response to stimulus	GO:0048584	323	0.020
positive regulation of biosynthetic process	GO:0009891	316	0.020
spermatid differentiation	GO:0048515	114	0.020
phenol containing compound metabolic process	GO:0018958	57	0.020
response to bacterium	GO:0009617	198	0.020
mating	GO:0007618	120	0.020
heterocycle catabolic process	GO:0046700	166	0.020
triglyceride biosynthetic process	GO:0019432	2	0.020
transmembrane transport	GO:0055085	139	0.019
phototaxis	GO:0042331	21	0.019
positive regulation of transport	GO:0051050	92	0.019
cellular response to chemical stimulus	GO:0070887	199	0.019
cholesterol homeostasis	GO:0042632	3	0.019
protein transport	GO:0015031	155	0.019
epidermis development	GO:0008544	65	0.019
cellular nitrogen compound catabolic process	GO:0044270	165	0.019
positive regulation of cell communication	GO:0010647	250	0.019
single organism intracellular transport	GO:1902582	207	0.019
phosphorylation	GO:0016310	294	0.019
cellular lipid metabolic process	GO:0044255	83	0.019
camera type eye development	GO:0043010	4	0.019
skin development	GO:0043588	65	0.019
cellular protein localization	GO:0034613	160	0.019
developmental growth	GO:0048589	280	0.019
protein localization	GO:0008104	284	0.019
apical junction assembly	GO:0043297	32	0.019
proteolysis	GO:0006508	192	0.019
intracellular protein transmembrane transport	GO:0065002	4	0.018
organonitrogen compound catabolic process	GO:1901565	128	0.018
lipid metabolic process	GO:0006629	121	0.018
regulation of neurotransmitter levels	GO:0001505	38	0.018
regulation of cellular localization	GO:0060341	136	0.018
aromatic compound catabolic process	GO:0019439	166	0.018
cell proliferation	GO:0008283	299	0.018
regulation of transport	GO:0051049	181	0.018
male gamete generation	GO:0048232	201	0.018
multi organism behavior	GO:0051705	175	0.018
negative regulation of cellular biosynthetic process	GO:0031327	277	0.018
insecticide metabolic process	GO:0017143	2	0.018
aging	GO:0007568	143	0.018
nicotinamide nucleotide metabolic process	GO:0046496	2	0.018
secretion	GO:0046903	109	0.018
regulation of intracellular signal transduction	GO:1902531	236	0.017
medium chain fatty acid metabolic process	GO:0051791	1	0.017
ovarian follicle cell migration	GO:0007297	121	0.017
cell adhesion	GO:0007155	136	0.017
cellular component assembly involved in morphogenesis	GO:0010927	151	0.017
regulation of tube size open tracheal system	GO:0035151	43	0.017
response to biotic stimulus	GO:0009607	294	0.017
tissue morphogenesis	GO:0048729	297	0.017
immune response	GO:0006955	246	0.017
negative regulation of biosynthetic process	GO:0009890	277	0.017
cell junction organization	GO:0034330	57	0.017
oxidation reduction process	GO:0055114	123	0.017
epidermal cell differentiation	GO:0009913	51	0.016
polyol biosynthetic process	GO:0046173	3	0.016
female meiotic division	GO:0007143	70	0.016
chaeta development	GO:0022416	97	0.016
neutral lipid biosynthetic process	GO:0046460	2	0.016
forebrain development	GO:0030900	2	0.016
homeostatic process	GO:0042592	199	0.016
maintenance of imaginal disc derived wing hair orientation	GO:0035321	3	0.016
purine containing compound metabolic process	GO:0072521	155	0.016
regulation of multicellular organismal development	GO:2000026	414	0.016
regulation of protein metabolic process	GO:0051246	256	0.016
response to copper ion	GO:0046688	4	0.016
meiotic cell cycle	GO:0051321	171	0.016
regulation of cellular amine metabolic process	GO:0033238	3	0.016
sulfur compound metabolic process	GO:0006790	59	0.016
neurological system process	GO:0050877	358	0.016
innate immune response	GO:0045087	144	0.016
detection of stimulus	GO:0051606	156	0.016
hair cell differentiation	GO:0035315	47	0.015
death	GO:0016265	284	0.015
cholesterol transport	GO:0030301	2	0.015
cellular macromolecule localization	GO:0070727	220	0.015
regulation of programmed cell death	GO:0043067	152	0.015
ion transport	GO:0006811	145	0.015
vitamin metabolic process	GO:0006766	2	0.015
peptide metabolic process	GO:0006518	80	0.015
triglyceride catabolic process	GO:0019433	3	0.015
tube development	GO:0035295	244	0.015
body morphogenesis	GO:0010171	2	0.015
androgen metabolic process	GO:0008209	1	0.015
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.015
sterol homeostasis	GO:0055092	4	0.015
regulation of cellular protein metabolic process	GO:0032268	243	0.015
cellular modified amino acid metabolic process	GO:0006575	45	0.015
establishment of protein localization	GO:0045184	163	0.015
regulation of cellular amino acid metabolic process	GO:0006521	0	0.015
organic cyclic compound catabolic process	GO:1901361	168	0.015
glycerolipid catabolic process	GO:0046503	3	0.014
response to alcohol	GO:0097305	95	0.014
embryonic morphogenesis	GO:0048598	206	0.014
intracellular signal transduction	GO:0035556	300	0.014
maintenance of location	GO:0051235	73	0.014
macromolecular complex assembly	GO:0065003	256	0.014
programmed cell death	GO:0012501	257	0.014
sensory perception	GO:0007600	196	0.014
nucleotide metabolic process	GO:0009117	161	0.014
estrogen metabolic process	GO:0008210	1	0.014
response to fungus	GO:0009620	50	0.014
positive regulation of signal transduction	GO:0009967	223	0.014
cellular response to ethanol	GO:0071361	4	0.014
kidney development	GO:0001822	3	0.014
establishment of blood nerve barrier	GO:0008065	2	0.014
positive regulation of gene expression	GO:0010628	290	0.014
meiotic nuclear division	GO:0007126	151	0.014
peripheral nervous system development	GO:0007422	52	0.014
response to nutrient levels	GO:0031667	114	0.014
defense response to bacterium	GO:0042742	178	0.014
nucleobase containing compound catabolic process	GO:0034655	165	0.014
eye development	GO:0001654	323	0.014
macromolecule catabolic process	GO:0009057	161	0.014
mesoderm development	GO:0007498	78	0.013
connective tissue development	GO:0061448	3	0.013
response to ethanol	GO:0045471	59	0.013
lipid localization	GO:0010876	54	0.013
cell adhesion involved in heart morphogenesis	GO:0061343	12	0.013
organonitrogen compound biosynthetic process	GO:1901566	117	0.013
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.013
nitrogen compound transport	GO:0071705	85	0.013
sensory organ morphogenesis	GO:0090596	260	0.013
negative regulation of gene expression	GO:0010629	387	0.013
regulation of catalytic activity	GO:0050790	185	0.013
encapsulation of foreign target	GO:0035010	38	0.013
pigmentation	GO:0043473	75	0.013
pyridine nucleotide metabolic process	GO:0019362	2	0.013
purine ribonucleoside metabolic process	GO:0046128	127	0.013
cellular amide metabolic process	GO:0043603	80	0.013
detection of chemical stimulus	GO:0009593	93	0.013
protein complex biogenesis	GO:0070271	201	0.013
carbohydrate derivative catabolic process	GO:1901136	118	0.012
hormone catabolic process	GO:0042447	3	0.012
actin filament based process	GO:0030029	220	0.012
protein complex assembly	GO:0006461	200	0.012
compound eye morphogenesis	GO:0001745	249	0.012
gland development	GO:0048732	191	0.012
transcription from rna polymerase ii promoter	GO:0006366	368	0.012
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.012
regulation of phosphorus metabolic process	GO:0051174	210	0.012
organic hydroxy compound catabolic process	GO:1901616	4	0.012
chemical homeostasis	GO:0048878	92	0.012
regulation of tube architecture open tracheal system	GO:0035152	68	0.012
positive regulation of cell motility	GO:2000147	3	0.012
phosphatidylethanolamine metabolic process	GO:0046337	1	0.012
cation transport	GO:0006812	110	0.012
regulation of cellular component biogenesis	GO:0044087	201	0.012
regulation of lipid transport	GO:0032368	3	0.012
intracellular protein transport	GO:0006886	104	0.012
immune effector process	GO:0002252	98	0.012
regulation of cell differentiation	GO:0045595	302	0.012
positive regulation of cell migration	GO:0030335	2	0.012
compound eye development	GO:0048749	307	0.012
intracellular protein transmembrane import	GO:0044743	4	0.012
cellular response to dna damage stimulus	GO:0006974	223	0.012
peptidyl amino acid modification	GO:0018193	105	0.012
organelle localization	GO:0051640	148	0.011
regulation of cell death	GO:0010941	173	0.011
adult behavior	GO:0030534	137	0.011
cellular response to organic substance	GO:0071310	132	0.011
defense response to fungus	GO:0050832	48	0.011
regulation of molecular function	GO:0065009	217	0.011
regulation of anatomical structure morphogenesis	GO:0022603	242	0.011
lipid biosynthetic process	GO:0008610	46	0.011
phosphatidic acid metabolic process	GO:0046473	1	0.011
embryonic development via the syncytial blastoderm	GO:0001700	148	0.011
glycosyl compound metabolic process	GO:1901657	127	0.011
wound healing	GO:0042060	75	0.011
positive regulation of rna biosynthetic process	GO:1902680	266	0.011
mitotic nuclear division	GO:0007067	213	0.011
response to extracellular stimulus	GO:0009991	116	0.011
dna metabolic process	GO:0006259	227	0.011
morphogenesis of an epithelium	GO:0002009	276	0.011
regulation of catabolic process	GO:0009894	170	0.011
meiotic cell cycle process	GO:1903046	132	0.011
glutathione metabolic process	GO:0006749	37	0.011
vitamin biosynthetic process	GO:0009110	1	0.011
energy taxis	GO:0009453	21	0.011
monocarboxylic acid transport	GO:0015718	3	0.011
regulation of cell cycle process	GO:0010564	181	0.011
neutral lipid catabolic process	GO:0046461	3	0.011
response to nitrogen compound	GO:1901698	90	0.011
salivary gland morphogenesis	GO:0007435	145	0.011
response to starvation	GO:0042594	97	0.011
purine nucleoside catabolic process	GO:0006152	112	0.011
g protein coupled receptor signaling pathway	GO:0007186	136	0.011
single organism carbohydrate metabolic process	GO:0044723	72	0.011
cellular macromolecule catabolic process	GO:0044265	136	0.011
cell cell junction assembly	GO:0007043	38	0.011
purine nucleoside metabolic process	GO:0042278	127	0.011
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.010
digestive system development	GO:0055123	149	0.010
organophosphate catabolic process	GO:0046434	112	0.010
tube morphogenesis	GO:0035239	191	0.010
regulation of phosphate metabolic process	GO:0019220	210	0.010
positive regulation of catalytic activity	GO:0043085	118	0.010
cytoplasmic transport	GO:0016482	130	0.010
purine ribonucleoside catabolic process	GO:0046130	112	0.010
apoptotic process	GO:0006915	159	0.010
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.010
eggshell chorion assembly	GO:0007306	66	0.010
benzene containing compound metabolic process	GO:0042537	3	0.010
multi multicellular organism process	GO:0044706	123	0.010
cellularization	GO:0007349	90	0.010
response to organic cyclic compound	GO:0014070	89	0.010
cell cell junction organization	GO:0045216	55	0.010
nucleoside catabolic process	GO:0009164	112	0.010
ribonucleoside metabolic process	GO:0009119	127	0.010
ribonucleoside catabolic process	GO:0042454	112	0.010

alpha-Est5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.029
disease of metabolism	DOID:0014667	0.027
diabetes mellitus	DOID:9351	0.023
carbohydrate metabolism disease	DOID:0050013	0.023
glucose metabolism disease	DOID:4194	0.023
acquired metabolic disease	DOID:0060158	0.023
inherited metabolic disorder	DOID:655	0.023
familial hyperlipidemia	DOID:1168	0.022
familial combined hyperlipidemia	DOID:13809	0.022
lipid metabolism disorder	DOID:3146	0.022
type 2 diabetes mellitus	DOID:9352	0.020
familial hypertriglyceridemia	DOID:0050527	0.019
nervous system disease	DOID:863	0.015
cardiovascular system disease	DOID:1287	0.014
artery disease	DOID:0050828	0.012
vascular disease	DOID:178	0.012
central nervous system disease	DOID:331	0.011
hypotrichosis	DOID:4535	0.010
integumentary system disease	DOID:16	0.010
hair disease	DOID:421	0.010

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