IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Rsf1 (Dmel_CG5655)

Repressor splicing factor 1

(Aliases: Dmel\CG5655,ROX21,RSF1,CG5655,Rox21,rox21)

FLYBASE: FBgn0011305
Entrez: 34370
UniProtKB: Q24491
UniProtKB: Q8SYR3

Process Predictions
Disease Predictions

Rsf1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.662
rna splicing	GO:0008380	83	0.607	Fly
mrna splicing via spliceosome	GO:0000398	73	0.596
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.402
positive regulation of macromolecule metabolic process	GO:0010604	405	0.401
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.325
negative regulation of cell cycle	GO:0045786	116	0.320
mrna processing	GO:0006397	104	0.295
negative regulation of rna metabolic process	GO:0051253	251	0.290
positive regulation of transcription dna templated	GO:0045893	266	0.290
rna splicing via transesterification reactions	GO:0000375	73	0.270
regulation of cell cycle	GO:0051726	291	0.267
rna processing	GO:0006396	147	0.266	Fly
positive regulation of rna metabolic process	GO:0051254	271	0.249
cellular response to dna damage stimulus	GO:0006974	223	0.247
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.240
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.227
epithelial cell development	GO:0002064	274	0.219
female meiosis chromosome segregation	GO:0016321	33	0.215
columnar cuboidal epithelial cell development	GO:0002066	249	0.207
positive regulation of rna biosynthetic process	GO:1902680	266	0.180
body morphogenesis	GO:0010171	2	0.175
positive regulation of biosynthetic process	GO:0009891	316	0.162
intracellular signal transduction	GO:0035556	300	0.153
positive regulation of gene expression	GO:0010628	290	0.153
alternative mrna splicing via spliceosome	GO:0000380	60	0.151
cell cycle phase transition	GO:0044770	140	0.151
mrna metabolic process	GO:0016071	124	0.150
chromatin modification	GO:0016568	147	0.147
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.146
negative regulation of gene expression	GO:0010629	387	0.144
regulation of rna splicing	GO:0043484	69	0.142
regulation of neurogenesis	GO:0050767	158	0.141
lateral inhibition	GO:0046331	206	0.141
mitotic nuclear division	GO:0007067	213	0.136
gland morphogenesis	GO:0022612	145	0.136
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.128
transcription from rna polymerase ii promoter	GO:0006366	368	0.125
mitotic g2 dna damage checkpoint	GO:0007095	69	0.124
sensory perception	GO:0007600	196	0.124
endocytosis	GO:0006897	310	0.124
ovarian follicle cell development	GO:0030707	248	0.122
negative regulation of transcription dna templated	GO:0045892	237	0.120
anterior posterior pattern specification	GO:0009952	136	0.119
developmental pigmentation	GO:0048066	68	0.116
macromolecular complex assembly	GO:0065003	256	0.116
compound eye morphogenesis	GO:0001745	249	0.112
chromosome segregation	GO:0007059	157	0.111
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.110
positive regulation of cellular biosynthetic process	GO:0031328	316	0.110
cytoskeleton dependent cytokinesis	GO:0061640	81	0.110
central nervous system development	GO:0007417	201	0.108
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.108
regulation of mrna splicing via spliceosome	GO:0048024	64	0.100
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.100
mitotic cell cycle checkpoint	GO:0007093	88	0.100
negative regulation of cellular metabolic process	GO:0031324	382	0.099
chromosome organization	GO:0051276	360	0.099
negative regulation of multicellular organismal process	GO:0051241	142	0.097
regulation of gene expression epigenetic	GO:0040029	128	0.095
exocrine system development	GO:0035272	162	0.092
regulation of anatomical structure morphogenesis	GO:0022603	242	0.091
regulation of cell differentiation	GO:0045595	302	0.090
meiotic cell cycle process	GO:1903046	132	0.090
negative regulation of rna biosynthetic process	GO:1902679	240	0.089
actin filament based process	GO:0030029	220	0.088
negative regulation of cellular biosynthetic process	GO:0031327	277	0.086
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.086
regulation of cell morphogenesis	GO:0022604	163	0.084
nucleosome organization	GO:0034728	59	0.081
adult behavior	GO:0030534	137	0.081
regulation of mrna processing	GO:0050684	71	0.079
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.079
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.079
positive regulation of cellular component biogenesis	GO:0044089	80	0.076
compound eye development	GO:0048749	307	0.076
developmental maturation	GO:0021700	172	0.073
regulation of multicellular organismal development	GO:2000026	414	0.073
eye development	GO:0001654	323	0.073
regulation of chromosome organization	GO:0033044	64	0.072
epithelial cell differentiation	GO:0030855	322	0.070
negative regulation of mitotic cell cycle	GO:0045930	109	0.070
cell motility	GO:0048870	251	0.069
r7 cell differentiation	GO:0045466	43	0.064
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.063
regulation of mrna metabolic process	GO:1903311	72	0.063
negative regulation of cell cycle process	GO:0010948	109	0.060
maintenance of location	GO:0051235	73	0.060
programmed cell death	GO:0012501	257	0.059
meiotic cell cycle	GO:0051321	171	0.058
regulation of organelle organization	GO:0033043	196	0.058
neurological system process	GO:0050877	358	0.058
phagocytosis	GO:0006909	215	0.056
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.056
cell death	GO:0008219	279	0.055
negative regulation of nervous system development	GO:0051961	92	0.055
phosphorylation	GO:0016310	294	0.054
gland development	GO:0048732	191	0.054
negative regulation of cell development	GO:0010721	62	0.054
positive regulation of intracellular signal transduction	GO:1902533	116	0.053
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.053
regulation of intracellular signal transduction	GO:1902531	236	0.052
detection of abiotic stimulus	GO:0009582	66	0.051
organelle fission	GO:0048285	340	0.050
protein modification process	GO:0036211	438	0.050
compound eye photoreceptor cell differentiation	GO:0001751	140	0.050
response to abiotic stimulus	GO:0009628	341	0.049
mitotic dna integrity checkpoint	GO:0044774	75	0.049
salivary gland development	GO:0007431	162	0.048
actin cytoskeleton organization	GO:0030036	206	0.047
histone modification	GO:0016570	106	0.046
salivary gland morphogenesis	GO:0007435	145	0.045
regulation of cell cycle process	GO:0010564	181	0.044
forebrain development	GO:0030900	2	0.043
regulation of cellular component biogenesis	GO:0044087	201	0.042
regulation of nervous system development	GO:0051960	248	0.042
cell division	GO:0051301	248	0.042
g2 dna damage checkpoint	GO:0031572	69	0.042
regulation of mitosis	GO:0007088	56	0.042
mrna cis splicing via spliceosome	GO:0045292	1	0.042
negative regulation of developmental process	GO:0051093	201	0.041
synapse organization	GO:0050808	196	0.041
dna integrity checkpoint	GO:0031570	81	0.041
protein dna complex subunit organization	GO:0071824	86	0.041
meiotic chromosome segregation	GO:0045132	59	0.039
response to radiation	GO:0009314	155	0.037
germarium derived egg chamber formation	GO:0007293	101	0.036
regulation of synapse organization	GO:0050807	110	0.036
mitotic cell cycle phase transition	GO:0044772	138	0.036
growth	GO:0040007	359	0.036
chromatin silencing	GO:0006342	76	0.035
muscle organ development	GO:0007517	127	0.034
regulation of phosphorus metabolic process	GO:0051174	210	0.033
negative regulation of cell differentiation	GO:0045596	143	0.033
regionalization	GO:0003002	416	0.033
positive regulation of phosphate metabolic process	GO:0045937	139	0.033
positive regulation of phosphorylation	GO:0042327	87	0.032
embryo development ending in birth or egg hatching	GO:0009792	152	0.032
covalent chromatin modification	GO:0016569	106	0.032
regulation of programmed cell death	GO:0043067	152	0.032
vesicle mediated transport	GO:0016192	381	0.031
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.031
brain development	GO:0007420	120	0.031
head development	GO:0060322	135	0.030
regulation of protein complex assembly	GO:0043254	42	0.030
regulation of cell division	GO:0051302	72	0.030
positive regulation of cellular component organization	GO:0051130	156	0.030
peptidyl amino acid modification	GO:0018193	105	0.030
regulation of cellular protein metabolic process	GO:0032268	243	0.030
organonitrogen compound metabolic process	GO:1901564	318	0.030
eggshell formation	GO:0030703	105	0.029
positive regulation of signal transduction	GO:0009967	223	0.029
negative regulation of neurogenesis	GO:0050768	53	0.029
mrna splice site selection	GO:0006376	1	0.028
dna metabolic process	GO:0006259	227	0.028
protein complex biogenesis	GO:0070271	201	0.028
small molecule metabolic process	GO:0044281	305	0.028
nuclear division	GO:0000280	332	0.028
telencephalon development	GO:0021537	2	0.028
mitotic spindle organization	GO:0007052	220	0.027
sensory organ morphogenesis	GO:0090596	260	0.027
female meiotic division	GO:0007143	70	0.027
gliogenesis	GO:0042063	80	0.027
regulation of nuclear division	GO:0051783	58	0.026
regulation of catalytic activity	GO:0050790	185	0.026
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.026
dna conformation change	GO:0071103	105	0.025
vesicle organization	GO:0016050	44	0.025
regulation of cell cycle phase transition	GO:1901987	130	0.025
death	GO:0016265	284	0.025
positive regulation of mapk cascade	GO:0043410	63	0.025
regulation of cellular amine metabolic process	GO:0033238	3	0.024
intrinsic apoptotic signaling pathway	GO:0097193	16	0.024
regulation of catabolic process	GO:0009894	170	0.024
positive regulation of phosphorus metabolic process	GO:0010562	139	0.024
negative regulation of cell cycle phase transition	GO:1901988	103	0.024
hindbrain development	GO:0030902	2	0.024
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.023
larval development	GO:0002164	104	0.023
dna templated transcription initiation	GO:0006352	25	0.023
regulation of synapse structure and activity	GO:0050803	128	0.023
negative regulation of biosynthetic process	GO:0009890	277	0.023
positive regulation of mitotic cell cycle	GO:0045931	34	0.023
organic substance catabolic process	GO:1901575	308	0.022
maintenance of protein location in cell	GO:0032507	26	0.022
meiotic nuclear division	GO:0007126	151	0.022
ovarian follicle cell migration	GO:0007297	121	0.021
neuron projection guidance	GO:0097485	241	0.021
cell cycle checkpoint	GO:0000075	95	0.021
retina development in camera type eye	GO:0060041	4	0.021
ras protein signal transduction	GO:0007265	88	0.021
cellular catabolic process	GO:0044248	372	0.021
ribonucleoprotein complex subunit organization	GO:0071826	28	0.021
regulation of protein metabolic process	GO:0051246	256	0.021
cellular macromolecular complex assembly	GO:0034622	153	0.020
small gtpase mediated signal transduction	GO:0007264	88	0.020
chromatin remodeling	GO:0006338	72	0.020
regulation of phosphate metabolic process	GO:0019220	210	0.020
regulation of cellular amino acid metabolic process	GO:0006521	0	0.020
macromolecule deacylation	GO:0098732	11	0.020
hematopoietic progenitor cell differentiation	GO:0002244	1	0.019
regulation of cytoskeleton organization	GO:0051493	89	0.019
negative regulation of chromatin silencing	GO:0031936	9	0.019
synapse assembly	GO:0007416	143	0.019
multicellular organismal aging	GO:0010259	140	0.019
chromosome separation	GO:0051304	42	0.019
single organism behavior	GO:0044708	391	0.019
peptidyl threonine modification	GO:0018210	3	0.019
stem cell differentiation	GO:0048863	117	0.019
regulation of translation	GO:0006417	56	0.018
regulation of cell shape	GO:0008360	113	0.018
regulation of cellular catabolic process	GO:0031329	157	0.018
protein complex assembly	GO:0006461	200	0.018
eye photoreceptor cell differentiation	GO:0001754	145	0.018
mitotic sister chromatid segregation	GO:0000070	87	0.018
cellular macromolecule localization	GO:0070727	220	0.018
multi organism reproductive behavior	GO:0044705	121	0.017
positive regulation of programmed cell death	GO:0043068	62	0.017
determination of dorsal ventral asymmetry	GO:0048262	3	0.017
autophagic cell death	GO:0048102	83	0.017
pole plasm oskar mrna localization	GO:0045451	46	0.017
cell fate specification	GO:0001708	71	0.017
positive regulation of organelle organization	GO:0010638	65	0.017
peptidyl lysine modification	GO:0018205	57	0.017
maintenance of location in cell	GO:0051651	28	0.017
chromatin organization	GO:0006325	207	0.016
regulation of mitotic cell cycle	GO:0007346	190	0.016
regulation of chromatin silencing	GO:0031935	36	0.016
response to other organism	GO:0051707	293	0.016
carboxylic acid metabolic process	GO:0019752	92	0.016
protein dna complex assembly	GO:0065004	63	0.016
cellular response to radiation	GO:0071478	52	0.016
eye morphogenesis	GO:0048592	260	0.016
peptidyl threonine phosphorylation	GO:0018107	2	0.016
histone h4 acetylation	GO:0043967	13	0.016
epithelial cell migration	GO:0010631	148	0.016
regulation of gene silencing	GO:0060968	63	0.016
ameboidal type cell migration	GO:0001667	151	0.015
negative regulation of cellular catabolic process	GO:0031330	34	0.015
protein modification by small protein conjugation	GO:0032446	79	0.015
organelle assembly	GO:0070925	198	0.015
cellular macromolecule catabolic process	GO:0044265	136	0.015
protein acetylation	GO:0006473	39	0.015
mitotic g2 m transition checkpoint	GO:0044818	70	0.015
regulation of organ morphogenesis	GO:2000027	78	0.015
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.015
actin filament organization	GO:0007015	126	0.015
chromatin assembly or disassembly	GO:0006333	52	0.015
cellular protein modification process	GO:0006464	438	0.015
regulation of neuron differentiation	GO:0045664	103	0.014
regulation of phosphorylation	GO:0042325	147	0.014
regulation of vesicle mediated transport	GO:0060627	59	0.014
histone acetylation	GO:0016573	38	0.014
regulation of mapk cascade	GO:0043408	92	0.014
appendage morphogenesis	GO:0035107	397	0.014
regulation of cell death	GO:0010941	173	0.014
wing disc pattern formation	GO:0035222	66	0.014
cellular amino acid metabolic process	GO:0006520	61	0.014
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.014
response to bacterium	GO:0009617	198	0.014
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.014
regulation of ras protein signal transduction	GO:0046578	93	0.014
regulation of cellular response to stress	GO:0080135	89	0.014
taxis	GO:0042330	304	0.014
mapk cascade	GO:0000165	107	0.014
cellular protein complex assembly	GO:0043623	71	0.013
cell cell junction organization	GO:0045216	55	0.013
positive regulation of protein metabolic process	GO:0051247	128	0.013
heterocycle catabolic process	GO:0046700	166	0.013
pole plasm assembly	GO:0007315	61	0.013
molting cycle	GO:0042303	56	0.013
anterior posterior axis specification	GO:0009948	109	0.013
male gamete generation	GO:0048232	201	0.013
tissue migration	GO:0090130	155	0.013
protein localization	GO:0008104	284	0.013
internal protein amino acid acetylation	GO:0006475	38	0.013
appendage development	GO:0048736	401	0.013
photoreceptor cell differentiation	GO:0046530	170	0.013
camera type eye development	GO:0043010	4	0.013
lipid localization	GO:0010876	54	0.012
positive regulation of cell communication	GO:0010647	250	0.012
single organism catabolic process	GO:0044712	228	0.012
positive regulation of cell death	GO:0010942	69	0.012
establishment of localization in cell	GO:0051649	402	0.012
dna packaging	GO:0006323	91	0.012
sister chromatid segregation	GO:0000819	92	0.012
regulation of mitotic sister chromatid separation	GO:0010965	28	0.012
rna localization	GO:0006403	115	0.012
ovarian nurse cell to oocyte transport	GO:0007300	27	0.012
rna catabolic process	GO:0006401	37	0.012
negative regulation of organelle organization	GO:0010639	56	0.012
positive regulation of cellular protein metabolic process	GO:0032270	118	0.012
cell cycle arrest	GO:0007050	4	0.012
cell maturation	GO:0048469	144	0.012
female sex differentiation	GO:0046660	20	0.012
oxoacid metabolic process	GO:0043436	103	0.012
mitotic spindle checkpoint	GO:0071174	11	0.012
regulation of apoptotic process	GO:0042981	130	0.012
spliceosomal complex assembly	GO:0000245	1	0.012
pole plasm rna localization	GO:0007316	52	0.011
membrane depolarization	GO:0051899	4	0.011
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.011
gonad development	GO:0008406	50	0.011
maintenance of protein location	GO:0045185	28	0.011
multicellular organismal reproductive behavior	GO:0033057	110	0.011
molting cycle process	GO:0022404	29	0.011
carbohydrate metabolic process	GO:0005975	82	0.011
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.011
endomembrane system organization	GO:0010256	119	0.011
positive regulation of signaling	GO:0023056	243	0.011
negative regulation of chromosome organization	GO:2001251	19	0.011
amine metabolic process	GO:0009308	12	0.011
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.011
positive regulation of ras protein signal transduction	GO:0046579	43	0.011
gene silencing	GO:0016458	138	0.011
regulation of response to stress	GO:0080134	200	0.011
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.011
pronuclear migration	GO:0035046	4	0.011
peptidyl lysine acetylation	GO:0018394	39	0.011
cellular response to organic substance	GO:0071310	132	0.011
posttranscriptional gene silencing	GO:0016441	46	0.011
signal transduction by phosphorylation	GO:0023014	107	0.011
translational elongation	GO:0006414	4	0.011
reproductive system development	GO:0061458	74	0.010
negative regulation of intracellular signal transduction	GO:1902532	57	0.010
reproductive structure development	GO:0048608	74	0.010
spindle organization	GO:0007051	253	0.010
apoptotic process	GO:0006915	159	0.010
catabolic process	GO:0009056	409	0.010
positive regulation of response to stimulus	GO:0048584	323	0.010
cell proliferation	GO:0008283	299	0.010
regulation of multi organism process	GO:0043900	131	0.010
myoblast fusion	GO:0007520	43	0.010

Rsf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.020
nervous system disease	DOID:863	0.014
neurodegenerative disease	DOID:1289	0.013
central nervous system disease	DOID:331	0.013
motor neuron disease	DOID:231	0.013
musculoskeletal system disease	DOID:17	0.012

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