IMP: Integrative Multi-species Prediction

Drosophila melanogaster

222 known processes

Rheb (Dmel_CG1081)

CG1081 gene product from transcript CG1081-RA

(Aliases: DReb,RheB,CG1081,Dmel\CG1081,Dm Rheb,DmRheb,rheb,RHEB,dRheb)

FLYBASE: FBgn0041191
Entrez: 117332
UniProtKB: H1ZYG4
UniProtKB: Q9VND8

Process Predictions
Disease Predictions

Rheb biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
autophagic vacuole assembly	GO:0000045	2	0.998
growth	GO:0040007	359	0.990
macroautophagy	GO:0016236	42	0.989
regulation of multicellular organism growth	GO:0040014	40	0.980
regulation of developmental growth	GO:0048638	174	0.975
regulation of growth	GO:0040008	233	0.968
tor signaling	GO:0031929	32	0.958
purine nucleotide metabolic process	GO:0006163	146	0.949
purine containing compound catabolic process	GO:0072523	112	0.941
multicellular organism growth	GO:0035264	46	0.941
ribonucleoside catabolic process	GO:0042454	112	0.932
regulation of tor signaling	GO:0032006	21	0.929
catabolic process	GO:0009056	409	0.929
cellular response to starvation	GO:0009267	61	0.927
organophosphate metabolic process	GO:0019637	195	0.927
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.925
positive regulation of macromolecule metabolic process	GO:0010604	405	0.924
chromosome organization	GO:0051276	360	0.924
autophagy	GO:0006914	108	0.922
ribose phosphate metabolic process	GO:0019693	145	0.917
nucleoside triphosphate catabolic process	GO:0009143	108	0.914
positive regulation of phosphate metabolic process	GO:0045937	139	0.913
regulation of autophagy	GO:0010506	62	0.911
purine ribonucleotide catabolic process	GO:0009154	109	0.911
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.906
cellular catabolic process	GO:0044248	372	0.906
purine nucleotide catabolic process	GO:0006195	109	0.894
cellular response to nutrient levels	GO:0031669	62	0.892
regulation of phosphorus metabolic process	GO:0051174	210	0.889
regulation of intracellular signal transduction	GO:1902531	236	0.882
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.879
glycosyl compound catabolic process	GO:1901658	112	0.875
cellular macromolecule localization	GO:0070727	220	0.871
columnar cuboidal epithelial cell development	GO:0002066	249	0.868
regulation of cellular catabolic process	GO:0031329	157	0.864
positive regulation of multicellular organism growth	GO:0040018	21	0.864
regulation of phosphate metabolic process	GO:0019220	210	0.858
intracellular signal transduction	GO:0035556	300	0.849
ovarian follicle cell development	GO:0030707	248	0.834
developmental growth	GO:0048589	280	0.832
positive regulation of catabolic process	GO:0009896	105	0.832
locomotor rhythm	GO:0045475	56	0.829
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.829
gtp catabolic process	GO:0006184	72	0.814
guanosine containing compound metabolic process	GO:1901068	74	0.812
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.811
cellular nitrogen compound catabolic process	GO:0044270	165	0.802
positive regulation of cell communication	GO:0010647	250	0.798
ribonucleotide metabolic process	GO:0009259	145	0.796
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.795
nucleotide catabolic process	GO:0009166	109	0.794
cellular protein localization	GO:0034613	160	0.790
ribonucleotide catabolic process	GO:0009261	109	0.789
positive regulation of growth	GO:0045927	75	0.780
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.779
cellular response to external stimulus	GO:0071496	66	0.772
positive regulation of developmental growth	GO:0048639	62	0.767
epithelial cell development	GO:0002064	274	0.765
gtp metabolic process	GO:0046039	72	0.754
small molecule metabolic process	GO:0044281	305	0.751
ribonucleoside metabolic process	GO:0009119	127	0.744
regulation of protein metabolic process	GO:0051246	256	0.742
cyclic nucleotide biosynthetic process	GO:0009190	25	0.738
purine ribonucleotide metabolic process	GO:0009150	145	0.733
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.732
positive regulation of cellular component organization	GO:0051130	156	0.726
intracellular transport	GO:0046907	228	0.719	Yeast
establishment of localization in cell	GO:0051649	402	0.716	Yeast
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.716
positive regulation of phosphorus metabolic process	GO:0010562	139	0.710
guanosine containing compound catabolic process	GO:1901069	74	0.703
regulation of catabolic process	GO:0009894	170	0.701
positive regulation of nucleotide metabolic process	GO:0045981	55	0.701
nucleoside catabolic process	GO:0009164	112	0.698
cellular response to extracellular stimulus	GO:0031668	64	0.695
negative regulation of autophagy	GO:0010507	16	0.691
erbb signaling pathway	GO:0038127	58	0.687
regulation of nucleotide metabolic process	GO:0006140	62	0.687
aging	GO:0007568	143	0.686
germarium derived egg chamber formation	GO:0007293	101	0.684
nucleotide metabolic process	GO:0009117	161	0.679
positive regulation of signal transduction	GO:0009967	223	0.670
endosomal transport	GO:0016197	44	0.668	Yeast
organelle fusion	GO:0048284	46	0.663
single organism membrane fusion	GO:0044801	42	0.662
larval midgut histolysis	GO:0035069	22	0.657
positive regulation of transcription dna templated	GO:0045893	266	0.648
determination of adult lifespan	GO:0008340	137	0.642
single organism intracellular transport	GO:1902582	207	0.634	Yeast
purine nucleoside metabolic process	GO:0042278	127	0.630
nucleoside triphosphate metabolic process	GO:0009141	120	0.624
regulation of anatomical structure size	GO:0090066	163	0.590
purine ribonucleoside catabolic process	GO:0046130	112	0.589
synaptic growth at neuromuscular junction	GO:0051124	119	0.585
regulation of ras gtpase activity	GO:0032318	38	0.582
purine ribonucleoside metabolic process	GO:0046128	127	0.560
aromatic compound catabolic process	GO:0019439	166	0.558
intracellular protein transport	GO:0006886	104	0.556
positive regulation of response to stimulus	GO:0048584	323	0.546
protein localization	GO:0008104	284	0.545
neuromuscular junction development	GO:0007528	149	0.544
nucleoside phosphate metabolic process	GO:0006753	162	0.543
positive regulation of cellular catabolic process	GO:0031331	95	0.535
regulation of cell growth	GO:0001558	43	0.525
carbohydrate derivative metabolic process	GO:1901135	217	0.516
purine containing compound metabolic process	GO:0072521	155	0.510
positive regulation of cellular protein metabolic process	GO:0032270	118	0.491
epithelial cell differentiation	GO:0030855	322	0.489
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.484
meiotic cell cycle	GO:0051321	171	0.481
regulation of dendrite morphogenesis	GO:0048814	28	0.481
synapse organization	GO:0050808	196	0.461
vesicle organization	GO:0016050	44	0.450
negative regulation of signaling	GO:0023057	219	0.448
nucleobase containing small molecule metabolic process	GO:0055086	174	0.448
membrane organization	GO:0061024	112	0.448
single organism membrane organization	GO:0044802	93	0.446
biological adhesion	GO:0022610	138	0.444
positive regulation of nucleoside metabolic process	GO:0045979	47	0.443
heterocycle catabolic process	GO:0046700	166	0.442
positive regulation of cellular biosynthetic process	GO:0031328	316	0.440
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.429
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.428
organic cyclic compound catabolic process	GO:1901361	168	0.426
cytoplasmic transport	GO:0016482	130	0.424
regulation of rho protein signal transduction	GO:0035023	20	0.420
regulation of cell cycle	GO:0051726	291	0.415
lipid metabolic process	GO:0006629	121	0.408
negative regulation of response to stimulus	GO:0048585	258	0.406
organophosphate catabolic process	GO:0046434	112	0.402
regulation of purine nucleotide metabolic process	GO:1900542	62	0.400
organic substance catabolic process	GO:1901575	308	0.399
single organism cellular localization	GO:1902580	180	0.399
organelle fission	GO:0048285	340	0.397
purine nucleoside catabolic process	GO:0006152	112	0.396
membrane fusion	GO:0061025	42	0.396
negative regulation of synapse assembly	GO:0051964	39	0.394
response to starvation	GO:0042594	97	0.389
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.388
phosphorylation	GO:0016310	294	0.378
glycosyl compound metabolic process	GO:1901657	127	0.376
endocytosis	GO:0006897	310	0.370
nucleoside phosphate catabolic process	GO:1901292	110	0.366
negative regulation of cell communication	GO:0010648	223	0.363
positive regulation of developmental process	GO:0051094	143	0.350
response to insulin	GO:0032868	29	0.348
positive regulation of nucleotide catabolic process	GO:0030813	46	0.345
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.344
nuclear division	GO:0000280	332	0.343
cellular protein modification process	GO:0006464	438	0.342
positive regulation of multicellular organismal process	GO:0051240	143	0.338
regulation of macroautophagy	GO:0016241	15	0.335
positive regulation of biosynthetic process	GO:0009891	316	0.335
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.328
protein localization to organelle	GO:0033365	82	0.325
skeletal muscle organ development	GO:0060538	48	0.323
body morphogenesis	GO:0010171	2	0.314
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.314
localization of cell	GO:0051674	257	0.313
regulation of phosphorylation	GO:0042325	147	0.312
organic substance transport	GO:0071702	257	0.312	Yeast
positive regulation of cell growth	GO:0030307	19	0.309
regulation of protein modification process	GO:0031399	112	0.278
regulation of cellular protein metabolic process	GO:0032268	243	0.277
nucleoside metabolic process	GO:0009116	127	0.276
carbohydrate derivative catabolic process	GO:1901136	118	0.276
microtubule based transport	GO:0010970	42	0.275
regulation of organ growth	GO:0046620	42	0.273
protein transport	GO:0015031	155	0.272
small gtpase mediated signal transduction	GO:0007264	88	0.269
dendrite development	GO:0016358	204	0.267
positive regulation of cellular amine metabolic process	GO:0033240	0	0.267
regulation of gtpase activity	GO:0043087	44	0.263
ras protein signal transduction	GO:0007265	88	0.259
regulation of nucleotide catabolic process	GO:0030811	48	0.258
single organism catabolic process	GO:0044712	228	0.256
cellular lipid metabolic process	GO:0044255	83	0.251
organonitrogen compound metabolic process	GO:1901564	318	0.249
negative regulation of signal transduction	GO:0009968	206	0.248
organelle assembly	GO:0070925	198	0.248
regulation of neuron differentiation	GO:0045664	103	0.246
regulation of purine nucleotide catabolic process	GO:0033121	48	0.245
cognition	GO:0050890	141	0.245
female meiotic division	GO:0007143	70	0.244
regulation of catalytic activity	GO:0050790	185	0.239
regulation of nucleoside metabolic process	GO:0009118	50	0.237
cellular response to insulin stimulus	GO:0032869	28	0.234
muscle structure development	GO:0061061	224	0.233
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.231
positive regulation of protein metabolic process	GO:0051247	128	0.230
regulation of mapk cascade	GO:0043408	92	0.229
cell proliferation	GO:0008283	299	0.227
regulation of apoptotic process	GO:0042981	130	0.224
axonogenesis	GO:0007409	290	0.223
cell motility	GO:0048870	251	0.222
regulation of localization	GO:0032879	275	0.216
ovarian follicle cell migration	GO:0007297	121	0.215
establishment of protein localization	GO:0045184	163	0.210
regulation of cytoskeleton organization	GO:0051493	89	0.207
positive regulation of signaling	GO:0023056	243	0.206
larval development	GO:0002164	104	0.205
vacuole organization	GO:0007033	8	0.204
single organism behavior	GO:0044708	391	0.201
microtubule based movement	GO:0007018	51	0.200
regulation of molecular function	GO:0065009	217	0.199	Human
establishment of organelle localization	GO:0051656	122	0.197
regulation of cellular component size	GO:0032535	98	0.191
cyclic nucleotide metabolic process	GO:0009187	28	0.191
muscle cell differentiation	GO:0042692	103	0.189
cellular amine metabolic process	GO:0044106	12	0.187
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.186
instar larval development	GO:0002168	55	0.185
sister chromatid segregation	GO:0000819	92	0.182
response to external biotic stimulus	GO:0043207	293	0.182
synapse assembly	GO:0007416	143	0.180
regulation of nucleotide biosynthetic process	GO:0030808	14	0.180
negative regulation of cellular metabolic process	GO:0031324	382	0.179
cell growth	GO:0016049	108	0.179
notch signaling pathway	GO:0007219	120	0.179
positive regulation of catalytic activity	GO:0043085	118	0.179
positive regulation of cell migration	GO:0030335	2	0.173
positive regulation of rna biosynthetic process	GO:1902680	266	0.171
positive regulation of cell size	GO:0045793	21	0.167
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.165
negative regulation of insulin receptor signaling pathway	GO:0046627	11	0.160
regulation of epithelial cell proliferation	GO:0050678	4	0.157
protein targeting	GO:0006605	64	0.156
eggshell formation	GO:0030703	105	0.156
positive regulation of molecular function	GO:0044093	136	0.156	Human
vacuolar transport	GO:0007034	13	0.154
organonitrogen compound catabolic process	GO:1901565	128	0.151
regulation of rac protein signal transduction	GO:0035020	3	0.149
germ line stem cell maintenance	GO:0030718	50	0.148
nucleobase containing compound catabolic process	GO:0034655	165	0.146
axon cargo transport	GO:0008088	29	0.145
regulation of anatomical structure morphogenesis	GO:0022603	242	0.144
neurological system process	GO:0050877	358	0.143
response to other organism	GO:0051707	293	0.143
micropyle formation	GO:0046844	4	0.142
rho protein signal transduction	GO:0007266	14	0.141
organelle localization	GO:0051640	148	0.141
regulation of cell differentiation	GO:0045595	302	0.138
macromolecular complex assembly	GO:0065003	256	0.135
molting cycle chitin based cuticle	GO:0007591	56	0.133
positive regulation of autophagy	GO:0010508	21	0.132
regulation of cellular localization	GO:0060341	136	0.131
chromosome segregation	GO:0007059	157	0.131
glycerolipid metabolic process	GO:0046486	34	0.129
positive regulation of rna metabolic process	GO:0051254	271	0.129
positive regulation of hydrolase activity	GO:0051345	78	0.128
entry into diapause	GO:0055115	1	0.128
cardiovascular system development	GO:0072358	82	0.128
signal transduction by phosphorylation	GO:0023014	107	0.127
negative regulation of growth	GO:0045926	84	0.127
chromatin organization	GO:0006325	207	0.126
regulation of gtp catabolic process	GO:0033124	44	0.126
axon development	GO:0061564	297	0.125
actin cytoskeleton organization	GO:0030036	206	0.125
negative regulation of growth of symbiont involved in interaction with host	GO:0044146	9	0.123
positive regulation of phosphorylation	GO:0042327	87	0.123
cellular protein catabolic process	GO:0044257	83	0.123
amine metabolic process	GO:0009308	12	0.122
positive regulation of gene expression	GO:0010628	290	0.120
regulation of cellular response to stress	GO:0080135	89	0.118
peripheral nervous system development	GO:0007422	52	0.118
negative regulation of macroautophagy	GO:0016242	6	0.116
regulation of nervous system development	GO:0051960	248	0.115
cell migration	GO:0016477	238	0.114
regulation of organelle organization	GO:0033043	196	0.114
mapk cascade	GO:0000165	107	0.114
transcription from rna polymerase ii promoter	GO:0006366	368	0.113
peptidyl threonine phosphorylation	GO:0018107	2	0.112
regulation of hydrolase activity	GO:0051336	97	0.111
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.111
regulation of cell size	GO:0008361	63	0.111
glycerophospholipid metabolic process	GO:0006650	23	0.110
camp biosynthetic process	GO:0006171	17	0.109
negative regulation of developmental process	GO:0051093	201	0.107
torc1 signaling	GO:0038202	12	0.107
establishment of nucleus localization	GO:0040023	26	0.106
cellular response to organonitrogen compound	GO:0071417	36	0.104
cytoskeleton dependent intracellular transport	GO:0030705	44	0.103
locomotory behavior	GO:0007626	176	0.102
circadian rhythm	GO:0007623	105	0.101
regulation of camp metabolic process	GO:0030814	12	0.100
regulation of response to nutrient levels	GO:0032107	18	0.099
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.097
atp metabolic process	GO:0046034	49	0.097
mitotic nuclear division	GO:0007067	213	0.097
regulation of programmed cell death	GO:0043067	152	0.096
regulation of dendrite development	GO:0050773	37	0.094
regulation of purine nucleotide biosynthetic process	GO:1900371	14	0.094
dorsal closure amnioserosa morphology change	GO:0046664	7	0.092
regulation of cell projection organization	GO:0031344	92	0.092
nucleoside monophosphate metabolic process	GO:0009123	52	0.091
proteolysis	GO:0006508	192	0.091
ameboidal type cell migration	GO:0001667	151	0.091
positive regulation of transport	GO:0051050	92	0.090
cellular response to chemical stimulus	GO:0070887	199	0.088
regulation of ras protein signal transduction	GO:0046578	93	0.087
larval midgut cell programmed cell death	GO:0035096	19	0.087
response to organonitrogen compound	GO:0010243	75	0.086
multicellular organismal aging	GO:0010259	140	0.086
negative regulation of intracellular signal transduction	GO:1902532	57	0.085
response to extracellular stimulus	GO:0009991	116	0.084
stress activated mapk cascade	GO:0051403	52	0.084
female germ line cyst formation	GO:0048135	42	0.083
epithelial cell migration	GO:0010631	148	0.083
positive regulation of organelle organization	GO:0010638	65	0.083
regulation of lyase activity	GO:0051339	14	0.082
molting cycle	GO:0042303	56	0.081
mitotic cell cycle checkpoint	GO:0007093	88	0.078
positive regulation of intracellular signal transduction	GO:1902533	116	0.078
positive regulation of mapk cascade	GO:0043410	63	0.078
cellular macromolecule catabolic process	GO:0044265	136	0.078
covalent chromatin modification	GO:0016569	106	0.078
positive regulation of gtpase activity	GO:0043547	43	0.077
protein complex assembly	GO:0006461	200	0.076
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.076
germ line cyst formation	GO:0048134	44	0.076
positive regulation of cell motility	GO:2000147	3	0.075
chemical homeostasis	GO:0048878	92	0.075
regulation of rho gtpase activity	GO:0032319	20	0.075
negative regulation of phosphatidylinositol 3 kinase signaling	GO:0014067	4	0.074
regulation of transport	GO:0051049	181	0.074
regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay	GO:1900151	4	0.073
modulation of growth of symbiont involved in interaction with host	GO:0044144	9	0.072
cell adhesion	GO:0007155	136	0.072
regulation of jnk cascade	GO:0046328	40	0.072
regulation of cell death	GO:0010941	173	0.072
establishment of protein localization to organelle	GO:0072594	62	0.072
protein modification process	GO:0036211	438	0.071
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.067
protein complex biogenesis	GO:0070271	201	0.066
multi organism behavior	GO:0051705	175	0.065
neuroblast proliferation	GO:0007405	74	0.065
regulation of intracellular protein transport	GO:0033157	46	0.064
endomembrane system organization	GO:0010256	119	0.063
negative regulation of developmental growth	GO:0048640	64	0.063
regulation of response to extracellular stimulus	GO:0032104	18	0.063
mitotic sister chromatid segregation	GO:0000070	87	0.062
regulation of synapse organization	GO:0050807	110	0.062
secretion	GO:0046903	109	0.062
endosomal vesicle fusion	GO:0034058	4	0.062
regulation of protein transport	GO:0051223	57	0.061
epithelium migration	GO:0090132	148	0.061
regulation of cellular amino acid metabolic process	GO:0006521	0	0.060
regulation of protein phosphorylation	GO:0001932	64	0.060
response to nutrient levels	GO:0031667	114	0.060
meiotic nuclear division	GO:0007126	151	0.059
germarium derived female germ line cyst formation	GO:0030727	42	0.059
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.059
cell division	GO:0051301	248	0.058
border follicle cell migration	GO:0007298	113	0.058
autophagic vacuole fusion	GO:0000046	15	0.058
cellular response to endogenous stimulus	GO:0071495	80	0.058
phagocytosis	GO:0006909	215	0.058
chorion containing eggshell formation	GO:0007304	105	0.057
dorsal closure	GO:0007391	79	0.057
cellularization	GO:0007349	90	0.057
macromolecule catabolic process	GO:0009057	161	0.055
developmental cell growth	GO:0048588	52	0.055
positive regulation of gtp catabolic process	GO:0033126	43	0.055
regulation of kinase activity	GO:0043549	53	0.055
regulation of cyclic nucleotide metabolic process	GO:0030799	13	0.055
regulation of tube size	GO:0035150	46	0.055
pigment metabolic process	GO:0042440	84	0.054
positive regulation of neurogenesis	GO:0050769	41	0.054
response to biotic stimulus	GO:0009607	294	0.053
positive regulation of protein localization to plasma membrane	GO:1903078	3	0.053
lateral inhibition	GO:0046331	206	0.053
meiotic cytokinesis	GO:0033206	33	0.053
regulation of immune system process	GO:0002682	176	0.053
collateral sprouting of injured axon	GO:0048674	3	0.053
regulation of synapse assembly	GO:0051963	94	0.052
positive regulation of establishment of protein localization to plasma membrane	GO:0090004	3	0.052
anterior midgut ectodermal morphogenesis	GO:0007441	4	0.050
endosome organization	GO:0007032	9	0.050
r7 cell differentiation	GO:0045466	43	0.050
regulation of neuron projection development	GO:0010975	69	0.050
negative regulation of apoptotic process	GO:0043066	63	0.049
response to oxidative stress	GO:0006979	86	0.049
response to nitrogen compound	GO:1901698	90	0.049
response to organic substance	GO:0010033	284	0.049
regulation of cell proliferation	GO:0042127	163	0.048
regulation of pathway restricted smad protein phosphorylation	GO:0060393	1	0.048
phosphatidylinositol phosphorylation	GO:0046854	10	0.047
vesicle fusion	GO:0006906	19	0.046
single organism biosynthetic process	GO:0044711	206	0.046
actin filament based process	GO:0030029	220	0.046
peptidyl amino acid modification	GO:0018193	105	0.046
regulation of mrna catabolic process	GO:0061013	5	0.045
striated muscle cell differentiation	GO:0051146	90	0.045
single organism nuclear import	GO:1902593	51	0.045
organelle membrane fusion	GO:0090174	16	0.044
lipid phosphorylation	GO:0046834	11	0.044
stem cell development	GO:0048864	79	0.044
cell death	GO:0008219	279	0.044
cellular response to peptide	GO:1901653	28	0.044
immune system process	GO:0002376	347	0.043
cell elongation involved in imaginal disc derived wing morphogenesis	GO:0090254	5	0.043
striated muscle cell development	GO:0055002	50	0.043
organophosphate biosynthetic process	GO:0090407	46	0.043
morphogenesis of an epithelium	GO:0002009	276	0.042
cellular response to organic substance	GO:0071310	132	0.042
regulation of nurse cell apoptotic process	GO:0045477	9	0.041
golgi vesicle transport	GO:0048193	27	0.041
plasma membrane organization	GO:0007009	26	0.041
dorsal closure spreading of leading edge cells	GO:0007395	4	0.040
circulatory system development	GO:0072359	82	0.040
appendage morphogenesis	GO:0035107	397	0.040
positive regulation of dendrite development	GO:1900006	9	0.040
regulation of stress activated mapk cascade	GO:0032872	41	0.040
defense response to other organism	GO:0098542	225	0.040
maintenance of protein location	GO:0045185	28	0.040
negative regulation of multicellular organismal process	GO:0051241	142	0.040
jnk cascade	GO:0007254	50	0.039
cellular homeostasis	GO:0019725	80	0.039
histone modification	GO:0016570	106	0.039
positive regulation of lipid biosynthetic process	GO:0046889	3	0.038
negative regulation of cell differentiation	GO:0045596	143	0.038
inositol lipid mediated signaling	GO:0048017	4	0.038
regulation of cell development	GO:0060284	215	0.037
establishment of protein localization to plasma membrane	GO:0090002	9	0.037
positive regulation of cell proliferation	GO:0008284	47	0.036
embryo development ending in birth or egg hatching	GO:0009792	152	0.036
cell aging	GO:0007569	2	0.036
negative regulation of nervous system development	GO:0051961	92	0.036
positive regulation of protein phosphorylation	GO:0001934	34	0.035
apoptotic process	GO:0006915	159	0.035
regulation of protein localization	GO:0032880	76	0.035
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.035
protein targeting to nucleus	GO:0044744	51	0.035
rhythmic process	GO:0048511	106	0.035
regulation of multicellular organismal development	GO:2000026	414	0.035
chemotaxis	GO:0006935	249	0.035
collateral sprouting	GO:0048668	3	0.034
negative regulation of neuron apoptotic process	GO:0043524	14	0.034
embryonic development via the syncytial blastoderm	GO:0001700	148	0.034
positive regulation of cell death	GO:0010942	69	0.034
positive regulation of nurse cell apoptotic process	GO:0045850	5	0.034
negative regulation of response to nutrient levels	GO:0032108	6	0.034
regulation of insulin receptor signaling pathway	GO:0046626	17	0.034
positive regulation of intracellular protein transport	GO:0090316	30	0.034
cellular response to nitrogen compound	GO:1901699	51	0.034
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.034
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	12	0.034
response to endogenous stimulus	GO:0009719	119	0.034
negative regulation of dendrite morphogenesis	GO:0050774	2	0.033
feeding behavior	GO:0007631	50	0.033
negative regulation of mitotic cell cycle	GO:0045930	109	0.033
oocyte differentiation	GO:0009994	145	0.033
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	26	0.033
regulation of synapse structural plasticity	GO:0051823	3	0.033
dormancy process	GO:0022611	2	0.032
regulation of protein localization to plasma membrane	GO:1903076	7	0.032
muscle tissue development	GO:0060537	30	0.032
nitrogen compound transport	GO:0071705	85	0.032	Yeast
dendrite morphogenesis	GO:0048813	199	0.032
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.032
mitochondrion degradation	GO:0000422	8	0.032
secretion by cell	GO:0032940	101	0.031
learning or memory	GO:0007611	141	0.031
skeletal muscle tissue development	GO:0007519	13	0.031
embryonic ectodermal digestive tract development	GO:0048611	4	0.031
insulin receptor signaling pathway	GO:0008286	25	0.031
regulation of imaginal disc growth	GO:0045570	26	0.030
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.030
phosphatidylinositol 3 kinase signaling	GO:0014065	4	0.030
positive regulation of tor signaling	GO:0032008	13	0.030
regulation of system process	GO:0044057	36	0.030
positive regulation of cytoskeleton organization	GO:0051495	21	0.030
ribose phosphate biosynthetic process	GO:0046390	28	0.030
regulation of r7 cell differentiation	GO:0045676	15	0.030
regulation of neurogenesis	GO:0050767	158	0.030
reactive oxygen species metabolic process	GO:0072593	22	0.029
regulation of cellular amine metabolic process	GO:0033238	3	0.029
chromatin modification	GO:0016568	147	0.029
sprouting of injured axon	GO:0048682	3	0.029
homeostatic process	GO:0042592	199	0.028
negative regulation of catalytic activity	GO:0043086	42	0.028
negative regulation of stress activated protein kinase signaling cascade	GO:0070303	20	0.028
cyclic purine nucleotide metabolic process	GO:0052652	25	0.028
cellular macromolecular complex assembly	GO:0034622	153	0.028
myotube differentiation	GO:0014902	46	0.028
positive regulation of programmed cell death	GO:0043068	62	0.028
lipid modification	GO:0030258	24	0.028
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.028
positive regulation of protein modification process	GO:0031401	58	0.028
gliogenesis	GO:0042063	80	0.028
vesicle mediated transport	GO:0016192	381	0.027	Yeast
regulation of actin filament length	GO:0030832	27	0.027
muscle organ development	GO:0007517	127	0.027
regulation of cell migration	GO:0030334	22	0.027
protein localization to nucleus	GO:0034504	55	0.027
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.027
regulation of cell morphogenesis	GO:0022604	163	0.027
positive regulation of lipid metabolic process	GO:0045834	4	0.027

Rheb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.030

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