IMP: Integrative Multi-species Prediction

Drosophila melanogaster

4 known processes

PPYR1 (Dmel_CG15031)

Protein phosphatase Y regulator 1

(Aliases: CG15031,BcDNA:AT19571,Dmel\CG15031)

FLYBASE: FBgn0030623
Entrez: 32453
UniProtKB: Q9VXX1

Process Predictions
Disease Predictions

PPYR1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
establishment of localization in cell	GO:0051649	402	0.055
regulation of catabolic process	GO:0009894	170	0.047
organic substance catabolic process	GO:1901575	308	0.043
organic substance transport	GO:0071702	257	0.040
protein transport	GO:0015031	155	0.039
catabolic process	GO:0009056	409	0.035
developmental programmed cell death	GO:0010623	138	0.028
programmed cell death	GO:0012501	257	0.027
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.026
organonitrogen compound metabolic process	GO:1901564	318	0.026
regulation of developmental growth	GO:0048638	174	0.026
positive regulation of response to stimulus	GO:0048584	323	0.025
single organism catabolic process	GO:0044712	228	0.025
small gtpase mediated signal transduction	GO:0007264	88	0.025
cellular catabolic process	GO:0044248	372	0.025
cellular amino acid metabolic process	GO:0006520	61	0.024
eye development	GO:0001654	323	0.022
camera type eye development	GO:0043010	4	0.022
l amino acid import	GO:0043092	2	0.021
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.020
positive regulation of phosphorus metabolic process	GO:0010562	139	0.019
positive regulation of signaling	GO:0023056	243	0.019
protein localization	GO:0008104	284	0.019
nucleus organization	GO:0006997	45	0.019
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.018
rna processing	GO:0006396	147	0.018
negative regulation of multicellular organismal process	GO:0051241	142	0.018
compound eye development	GO:0048749	307	0.018
regulation of cellular ketone metabolic process	GO:0010565	3	0.017
regulation of multicellular organismal development	GO:2000026	414	0.017
regulation of protein localization	GO:0032880	76	0.016
positive regulation of cellular biosynthetic process	GO:0031328	316	0.016
macromolecule catabolic process	GO:0009057	161	0.016
small molecule metabolic process	GO:0044281	305	0.016
negative regulation of cellular metabolic process	GO:0031324	382	0.016
regionalization	GO:0003002	416	0.016
body morphogenesis	GO:0010171	2	0.016
forebrain development	GO:0030900	2	0.016
positive regulation of signal transduction	GO:0009967	223	0.016
oxoacid metabolic process	GO:0043436	103	0.016
regulation of cellular amine metabolic process	GO:0033238	3	0.016
regulation of cellular catabolic process	GO:0031329	157	0.015
ras protein signal transduction	GO:0007265	88	0.015
intracellular transport	GO:0046907	228	0.015
homeostatic process	GO:0042592	199	0.015
phosphorylation	GO:0016310	294	0.015
developmental growth	GO:0048589	280	0.015
retina development in camera type eye	GO:0060041	4	0.015
chromatin silencing	GO:0006342	76	0.015
positive regulation of cell communication	GO:0010647	250	0.015
regulation of chromatin silencing	GO:0031935	36	0.015
regulation of molecular function	GO:0065009	217	0.015
regulation of localization	GO:0032879	275	0.015
exocrine system development	GO:0035272	162	0.015
chromatin remodeling	GO:0006338	72	0.014
regulation of ras protein signal transduction	GO:0046578	93	0.014
regulation of protein transport	GO:0051223	57	0.014
apoptotic process	GO:0006915	159	0.014
negative regulation of rna biosynthetic process	GO:1902679	240	0.014
regulation of transport	GO:0051049	181	0.014
regulation of gene expression epigenetic	GO:0040029	128	0.014
positive regulation of intracellular signal transduction	GO:1902533	116	0.014
cell death	GO:0008219	279	0.014
modification dependent protein catabolic process	GO:0019941	78	0.014
compound eye morphogenesis	GO:0001745	249	0.013
telencephalon development	GO:0021537	2	0.013
positive regulation of transcription dna templated	GO:0045893	266	0.013
regulation of cellular localization	GO:0060341	136	0.013
positive regulation of molecular function	GO:0044093	136	0.013
gland morphogenesis	GO:0022612	145	0.013
establishment of protein localization	GO:0045184	163	0.013
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.013
positive regulation of cellular component biogenesis	GO:0044089	80	0.013
response to oxygen containing compound	GO:1901700	200	0.013
regulation of cellular amino acid metabolic process	GO:0006521	0	0.013
negative regulation of gene expression	GO:0010629	387	0.013
death	GO:0016265	284	0.013
regulation of programmed cell death	GO:0043067	152	0.013
dorsal ventral pattern formation	GO:0009953	133	0.013
positive regulation of gene expression	GO:0010628	290	0.013
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.013
positive regulation of catalytic activity	GO:0043085	118	0.013
rrna processing	GO:0006364	3	0.013
organonitrogen compound catabolic process	GO:1901565	128	0.013
negative regulation of gene expression epigenetic	GO:0045814	77	0.012
gland development	GO:0048732	191	0.012
chemical homeostasis	GO:0048878	92	0.012
appendage development	GO:0048736	401	0.012
organic acid metabolic process	GO:0006082	103	0.012
carbohydrate derivative catabolic process	GO:1901136	118	0.012
protein secretion	GO:0009306	45	0.012
aromatic compound catabolic process	GO:0019439	166	0.012
synaptic growth at neuromuscular junction	GO:0051124	119	0.012
salivary gland cell autophagic cell death	GO:0035071	83	0.012
kidney development	GO:0001822	3	0.012
regulation of gene silencing	GO:0060968	63	0.012
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.012
positive regulation of hydrolase activity	GO:0051345	78	0.012
positive regulation of macromolecule metabolic process	GO:0010604	405	0.012
regulation of cell death	GO:0010941	173	0.012
regulation of nucleotide catabolic process	GO:0030811	48	0.012
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.012
cellular nitrogen compound catabolic process	GO:0044270	165	0.012
rna localization	GO:0006403	115	0.011
purine nucleoside catabolic process	GO:0006152	112	0.011
cellular ketone metabolic process	GO:0042180	24	0.011
positive regulation of cellular amine metabolic process	GO:0033240	0	0.011
carbohydrate derivative metabolic process	GO:1901135	217	0.011
nucleoside phosphate catabolic process	GO:1901292	110	0.011
single organism intracellular transport	GO:1902582	207	0.011
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.011
ribonucleotide catabolic process	GO:0009261	109	0.011
positive regulation of phosphorylation	GO:0042327	87	0.011
gene silencing	GO:0016458	138	0.011
endomembrane system organization	GO:0010256	119	0.011
negative regulation of cellular biosynthetic process	GO:0031327	277	0.011
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.011
sister chromatid segregation	GO:0000819	92	0.011
nucleobase containing compound catabolic process	GO:0034655	165	0.011
regulation of secretion by cell	GO:1903530	39	0.011
tissue death	GO:0016271	102	0.011
regulation of hydrolase activity	GO:0051336	97	0.011
negative regulation of developmental growth	GO:0048640	64	0.011
synapse assembly	GO:0007416	143	0.011
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.010
regulation of establishment of protein localization	GO:0070201	61	0.010
salivary gland development	GO:0007431	162	0.010
positive regulation of catabolic process	GO:0009896	105	0.010
learning	GO:0007612	75	0.010
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.010
ribose phosphate metabolic process	GO:0019693	145	0.010
response to hexose	GO:0009746	3	0.010

PPYR1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.031
nervous system disease	DOID:863	0.025
sensory system disease	DOID:0050155	0.015
disease of metabolism	DOID:0014667	0.014
inherited metabolic disorder	DOID:655	0.011
type 2 diabetes mellitus	DOID:9352	0.010
carbohydrate metabolism disease	DOID:0050013	0.010
glucose metabolism disease	DOID:4194	0.010
acquired metabolic disease	DOID:0060158	0.010
diabetes mellitus	DOID:9351	0.010

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