IMP: Integrative Multi-species Prediction

Drosophila melanogaster

104 known processes

hipk (Dmel_CG17090)

homeodomain interacting protein kinase

(Aliases: CG17090,dhipk2,HIPK,Dmel\CG17090)

Entrez: 38070
FLYBASE: FBgn0035142
UniProtKB: M9PDR2
UniProtKB: Q9W0Q1

Process Predictions
Disease Predictions

hipk biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
eye development	GO:0001654	323	0.993
imaginal disc derived appendage development	GO:0048737	399	0.992
appendage development	GO:0048736	401	0.976
compound eye development	GO:0048749	307	0.962
eye morphogenesis	GO:0048592	260	0.962	Mouse
imaginal disc derived wing morphogenesis	GO:0007476	337	0.945
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.921
negative regulation of signal transduction	GO:0009968	206	0.918	Human Mouse
appendage morphogenesis	GO:0035107	397	0.916
taxis	GO:0042330	304	0.877
sensory organ morphogenesis	GO:0090596	260	0.867	Mouse
heart development	GO:0007507	82	0.852
wing disc morphogenesis	GO:0007472	344	0.831
negative regulation of cellular biosynthetic process	GO:0031327	277	0.811	Human Mouse
compound eye morphogenesis	GO:0001745	249	0.802
post embryonic appendage morphogenesis	GO:0035120	385	0.799
regionalization	GO:0003002	416	0.797	Mouse
negative regulation of gene expression	GO:0010629	387	0.796	Mouse
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.774	Human Mouse
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.762	Mouse
morphogenesis of an epithelium	GO:0002009	276	0.749
synapse organization	GO:0050808	196	0.740
positive regulation of cellular biosynthetic process	GO:0031328	316	0.732	Human Mouse
phosphorylation	GO:0016310	294	0.693
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.653
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.644	Human Mouse
regulation of cell proliferation	GO:0042127	163	0.642	Mouse
regulation of protein metabolic process	GO:0051246	256	0.641	Mouse
synapse assembly	GO:0007416	143	0.639
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.629	Human Mouse
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.608	Human Mouse
regulation of phosphorylation	GO:0042325	147	0.600	Human Mouse
positive regulation of gene expression	GO:0010628	290	0.600	Human Mouse
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.598	Human Mouse
protein phosphorylation	GO:0006468	169	0.593
positive regulation of rna metabolic process	GO:0051254	271	0.575	Human Mouse
eye photoreceptor cell differentiation	GO:0001754	145	0.574
axonogenesis	GO:0007409	290	0.564
negative regulation of response to stimulus	GO:0048585	258	0.549	Human Mouse
cellular response to chemical stimulus	GO:0070887	199	0.541	Human Mouse
regulation of erbb signaling pathway	GO:1901184	42	0.537
regulation of cell cycle	GO:0051726	291	0.522
compound eye photoreceptor cell differentiation	GO:0001751	140	0.511
positive regulation of phosphate metabolic process	GO:0045937	139	0.503	Human Mouse
response to abiotic stimulus	GO:0009628	341	0.495
regulation of synapse structure and activity	GO:0050803	128	0.488
establishment or maintenance of cell polarity	GO:0007163	167	0.487
negative regulation of cell communication	GO:0010648	223	0.476	Human Mouse
developmental growth	GO:0048589	280	0.474
positive regulation of cell migration	GO:0030335	2	0.473
embryonic development via the syncytial blastoderm	GO:0001700	148	0.454
localization of cell	GO:0051674	257	0.439
response to organic substance	GO:0010033	284	0.437	Human Mouse
response to gravity	GO:0009629	26	0.430
epithelial cell differentiation	GO:0030855	322	0.424	Zebrafish
single organism cellular localization	GO:1902580	180	0.424
biological adhesion	GO:0022610	138	0.423
cell migration	GO:0016477	238	0.418
positive regulation of molecular function	GO:0044093	136	0.411	Mouse
compound eye photoreceptor development	GO:0042051	78	0.398
intracellular transport	GO:0046907	228	0.397
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.396	Human Mouse
catabolic process	GO:0009056	409	0.391
detection of stimulus	GO:0051606	156	0.389
photoreceptor cell differentiation	GO:0046530	170	0.380
positive regulation of macromolecule metabolic process	GO:0010604	405	0.376	Human Mouse
regulation of intracellular signal transduction	GO:1902531	236	0.374
wnt signaling pathway	GO:0016055	98	0.372
ameboidal type cell migration	GO:0001667	151	0.372
defense response	GO:0006952	300	0.368
single organism intracellular transport	GO:1902582	207	0.367
lateral inhibition	GO:0046331	206	0.367
regulation of cellular protein metabolic process	GO:0032268	243	0.353	Mouse
tissue morphogenesis	GO:0048729	297	0.351	Mouse
heterocycle catabolic process	GO:0046700	166	0.351
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.348	Mouse
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.347
cellular protein modification process	GO:0006464	438	0.339
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.334	Human Mouse
positive regulation of response to stimulus	GO:0048584	323	0.329
spermatid differentiation	GO:0048515	114	0.329
reproductive system development	GO:0061458	74	0.327
regulation of cell death	GO:0010941	173	0.325
growth	GO:0040007	359	0.322
death	GO:0016265	284	0.317
hematopoietic or lymphoid organ development	GO:0048534	57	0.316
embryonic morphogenesis	GO:0048598	206	0.315	Mouse
positive regulation of rna biosynthetic process	GO:1902680	266	0.309	Human Mouse
neurological system process	GO:0050877	358	0.303
immune system process	GO:0002376	347	0.299
regulation of wnt signaling pathway	GO:0030111	68	0.299
dorsal ventral pattern formation	GO:0009953	133	0.296
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.295	Human Mouse
cell death	GO:0008219	279	0.290
axon midline choice point recognition	GO:0016199	26	0.286
negative regulation of signaling	GO:0023057	219	0.285	Human Mouse
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.278
single organismal cell cell adhesion	GO:0016337	45	0.275
regulation of nervous system development	GO:0051960	248	0.274
asymmetric stem cell division	GO:0098722	49	0.274
cell proliferation	GO:0008283	299	0.273	Mouse
negative regulation of wnt signaling pathway	GO:0030178	28	0.273
regulation of programmed cell death	GO:0043067	152	0.273
forebrain development	GO:0030900	2	0.273
apoptotic process	GO:0006915	159	0.272	Human Mouse
morphogenesis of a polarized epithelium	GO:0001738	93	0.270
regulation of protein modification process	GO:0031399	112	0.268	Mouse
positive regulation of transcription dna templated	GO:0045893	266	0.264	Human Mouse
establishment of cell polarity	GO:0030010	40	0.264
circulatory system development	GO:0072359	82	0.261	Human
cellular macromolecule catabolic process	GO:0044265	136	0.261
regulation of molecular function	GO:0065009	217	0.260	Mouse
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.258
r7 cell differentiation	GO:0045466	43	0.257
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.251
skin development	GO:0043588	65	0.250
negative regulation of intracellular signal transduction	GO:1902532	57	0.247	Mouse
cytoplasmic transport	GO:0016482	130	0.244
intracellular protein transport	GO:0006886	104	0.243
axon development	GO:0061564	297	0.239
immune system development	GO:0002520	57	0.239
positive regulation of cell motility	GO:2000147	3	0.236
actin filament based process	GO:0030029	220	0.236
response to biotic stimulus	GO:0009607	294	0.236
cellularization	GO:0007349	90	0.233
actin cytoskeleton organization	GO:0030036	206	0.227
posttranscriptional regulation of gene expression	GO:0010608	145	0.226
regulation of mapk cascade	GO:0043408	92	0.224	Human Mouse
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.224
regulation of response to stress	GO:0080134	200	0.220	Human Mouse
erbb signaling pathway	GO:0038127	58	0.208
immune response	GO:0006955	246	0.207
wing disc pattern formation	GO:0035222	66	0.207
epithelial cell migration	GO:0010631	148	0.207
epidermis development	GO:0008544	65	0.205
intracellular signal transduction	GO:0035556	300	0.202
vesicle mediated transport	GO:0016192	381	0.201
regulation of cell differentiation	GO:0045595	302	0.201	Zebrafish
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.199
signal transduction by phosphorylation	GO:0023014	107	0.199	Human Mouse
regulation of system process	GO:0044057	36	0.197
regulation of neurogenesis	GO:0050767	158	0.196
cell motility	GO:0048870	251	0.194
response to other organism	GO:0051707	293	0.193
kidney epithelium development	GO:0072073	3	0.193
cellular catabolic process	GO:0044248	372	0.190
tissue migration	GO:0090130	155	0.190
cell adhesion	GO:0007155	136	0.189
synaptic growth at neuromuscular junction	GO:0051124	119	0.188
eye photoreceptor cell development	GO:0042462	81	0.185
regulation of cell motility	GO:2000145	23	0.183
negative regulation of transcription dna templated	GO:0045892	237	0.183	Mouse
macromolecule catabolic process	GO:0009057	161	0.181
regulation of gene expression epigenetic	GO:0040029	128	0.180
carboxylic acid metabolic process	GO:0019752	92	0.179
ras protein signal transduction	GO:0007265	88	0.172
organic substance transport	GO:0071702	257	0.171
regulation of mitotic cell cycle	GO:0007346	190	0.171
positive regulation of phosphorus metabolic process	GO:0010562	139	0.171	Human Mouse
protein modification process	GO:0036211	438	0.171
regulation of epithelial cell migration	GO:0010632	12	0.170
small molecule metabolic process	GO:0044281	305	0.170
organic substance catabolic process	GO:1901575	308	0.169
negative regulation of programmed cell death	GO:0043069	72	0.169	Human Mouse
mrna metabolic process	GO:0016071	124	0.163
circulatory system process	GO:0003013	37	0.163
positive regulation of synapse assembly	GO:0051965	29	0.163
negative regulation of erbb signaling pathway	GO:1901185	29	0.161
negative regulation of developmental process	GO:0051093	201	0.160
macromolecular complex assembly	GO:0065003	256	0.160
stem cell development	GO:0048864	79	0.160
positive regulation of protein metabolic process	GO:0051247	128	0.158	Mouse
negative regulation of cellular metabolic process	GO:0031324	382	0.157	Human Mouse
regulation of protein kinase activity	GO:0045859	51	0.154	Mouse
renal tubule development	GO:0061326	64	0.154
transcription from rna polymerase ii promoter	GO:0006366	368	0.153	Mouse
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.153	Zebrafish
mapk cascade	GO:0000165	107	0.152	Human Mouse
hindbrain development	GO:0030902	2	0.150
response to external biotic stimulus	GO:0043207	293	0.148
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.148	Human Mouse
digestive system development	GO:0055123	149	0.147
single organism carbohydrate metabolic process	GO:0044723	72	0.147
head development	GO:0060322	135	0.142
nucleobase containing compound catabolic process	GO:0034655	165	0.142
regulation of cellular component biogenesis	GO:0044087	201	0.141
small gtpase mediated signal transduction	GO:0007264	88	0.141
organic acid metabolic process	GO:0006082	103	0.138
response to endogenous stimulus	GO:0009719	119	0.137	Human Mouse
establishment of protein localization to organelle	GO:0072594	62	0.137
fibroblast growth factor receptor signaling pathway	GO:0008543	10	0.134
protein transport	GO:0015031	155	0.134
positive regulation of cell proliferation	GO:0008284	47	0.134	Mouse
negative regulation of protein phosphorylation	GO:0001933	17	0.133	Mouse
cell cycle phase transition	GO:0044770	140	0.132
regulation of organ morphogenesis	GO:2000027	78	0.131
cell growth	GO:0016049	108	0.130
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.130
oxoacid metabolic process	GO:0043436	103	0.129
ectodermal placode morphogenesis	GO:0071697	4	0.129
negative regulation of rna metabolic process	GO:0051253	251	0.127	Human Mouse
negative regulation of rna biosynthetic process	GO:1902679	240	0.127	Human Mouse
response to oxidative stress	GO:0006979	86	0.126
cellular response to dna damage stimulus	GO:0006974	223	0.125	Human Mouse
muscle cell differentiation	GO:0042692	103	0.124
blood circulation	GO:0008015	26	0.124
mrna catabolic process	GO:0006402	33	0.123
aromatic compound catabolic process	GO:0019439	166	0.122
organ formation	GO:0048645	39	0.122
establishment of localization in cell	GO:0051649	402	0.121
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.120	Human Mouse
homeostatic process	GO:0042592	199	0.118
cellular macromolecule localization	GO:0070727	220	0.118
asymmetric neuroblast division	GO:0055059	33	0.117
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.116	Mouse
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.114	Human Mouse
negative regulation of biosynthetic process	GO:0009890	277	0.113	Human Mouse
modification dependent macromolecule catabolic process	GO:0043632	79	0.113
tube development	GO:0035295	244	0.112
regulation of ras protein signal transduction	GO:0046578	93	0.110
imaginal disc pattern formation	GO:0007447	91	0.110
positive regulation of cell communication	GO:0010647	250	0.110
positive regulation of endopeptidase activity	GO:0010950	26	0.109
respiratory system development	GO:0060541	213	0.108
regulation of phosphate metabolic process	GO:0019220	210	0.107	Human Mouse
positive regulation of cellular protein metabolic process	GO:0032270	118	0.107	Mouse
cell division	GO:0051301	248	0.106
regulation of neural precursor cell proliferation	GO:2000177	35	0.106
positive regulation of lipid catabolic process	GO:0050996	1	0.105
spermatogenesis	GO:0007283	200	0.105
response to extracellular stimulus	GO:0009991	116	0.103
exocrine system development	GO:0035272	162	0.103
organonitrogen compound metabolic process	GO:1901564	318	0.103
neuron projection guidance	GO:0097485	241	0.103
nephron morphogenesis	GO:0072028	3	0.102
regulation of cellular component movement	GO:0051270	42	0.100
hemopoiesis	GO:0030097	46	0.100
regulation of apoptotic process	GO:0042981	130	0.099	Human Mouse
photoreceptor cell development	GO:0042461	96	0.099
regulation of neuron differentiation	GO:0045664	103	0.098
dna metabolic process	GO:0006259	227	0.097
response to nutrient levels	GO:0031667	114	0.096
notch signaling pathway	GO:0007219	120	0.096
humoral immune response	GO:0006959	117	0.095
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	26	0.095
mitotic cell cycle phase transition	GO:0044772	138	0.095
translation	GO:0006412	69	0.094
negative regulation of phosphorus metabolic process	GO:0010563	45	0.094	Mouse
sperm individualization	GO:0007291	48	0.092
carbohydrate biosynthetic process	GO:0016051	17	0.092
neuromuscular junction development	GO:0007528	149	0.091
negative regulation of cell differentiation	GO:0045596	143	0.091
regulation of growth	GO:0040008	233	0.090
phagocytosis	GO:0006909	215	0.087
regulation of locomotion	GO:0040012	42	0.087
regulation of kinase activity	GO:0043549	53	0.087	Mouse
aging	GO:0007568	143	0.087	Worm
regulation of intracellular transport	GO:0032386	64	0.086
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.084
oocyte axis specification	GO:0007309	108	0.084
negative regulation of protein metabolic process	GO:0051248	85	0.084	Mouse
spermatid development	GO:0007286	98	0.082
regulation of cellular amino acid metabolic process	GO:0006521	0	0.082
morphogenesis of embryonic epithelium	GO:0016331	94	0.082
protein modification by small protein conjugation or removal	GO:0070647	106	0.082
regulation of cell cycle phase transition	GO:1901987	130	0.081
carbohydrate derivative metabolic process	GO:1901135	217	0.081
response to drug	GO:0042493	17	0.081
dorsal closure	GO:0007391	79	0.080
dendrite morphogenesis	GO:0048813	199	0.080
gland development	GO:0048732	191	0.080
response to bacterium	GO:0009617	198	0.079
oocyte construction	GO:0007308	112	0.078
formation of anatomical boundary	GO:0048859	37	0.078
positive regulation of intracellular signal transduction	GO:1902533	116	0.078
negative regulation of cellular protein metabolic process	GO:0032269	85	0.078	Mouse
autophagy	GO:0006914	108	0.077
cellular response to organonitrogen compound	GO:0071417	36	0.077
regulation of synapse assembly	GO:0051963	94	0.076
programmed cell death	GO:0012501	257	0.076
axon guidance	GO:0007411	233	0.076
negative regulation of cell cycle	GO:0045786	116	0.075
proteolysis	GO:0006508	192	0.075
positive regulation of signaling	GO:0023056	243	0.075
maintenance of gastrointestinal epithelium	GO:0030277	3	0.074
posttranscriptional gene silencing by rna	GO:0035194	45	0.074
male gamete generation	GO:0048232	201	0.074
embryo development ending in birth or egg hatching	GO:0009792	152	0.073
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.073
dna repair	GO:0006281	54	0.073
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.072	Mouse
segmentation	GO:0035282	207	0.072
cellular response to endogenous stimulus	GO:0071495	80	0.072	Human Mouse
cellular response to organic substance	GO:0071310	132	0.072	Human Mouse
cellular nitrogen compound catabolic process	GO:0044270	165	0.071
cell fate specification	GO:0001708	71	0.071
regulation of neuroblast proliferation	GO:1902692	34	0.071
nephron development	GO:0072006	3	0.071
negative regulation of small gtpase mediated signal transduction	GO:0051058	13	0.070
canonical wnt signaling pathway	GO:0060070	21	0.070
rho protein signal transduction	GO:0007266	14	0.070
regulation of protein phosphorylation	GO:0001932	64	0.070	Mouse
positive regulation of locomotion	GO:0040017	8	0.069
regulation of endopeptidase activity	GO:0052548	36	0.069
regulation of catalytic activity	GO:0050790	185	0.069	Mouse
positive regulation of phosphorylation	GO:0042327	87	0.069	Human Mouse
response to glucose	GO:0009749	2	0.068
epithelial cell development	GO:0002064	274	0.068
stem cell maintenance	GO:0019827	67	0.068
protein catabolic process	GO:0030163	101	0.067
apoptotic signaling pathway	GO:0097190	27	0.067	Human Mouse
cellular protein localization	GO:0034613	160	0.067
semaphorin plexin signaling pathway	GO:0071526	4	0.067
detection of external stimulus	GO:0009581	66	0.067
regulation of intracellular protein transport	GO:0033157	46	0.066
sensory perception	GO:0007600	196	0.066
embryonic organ development	GO:0048568	50	0.066	Mouse
embryonic pattern specification	GO:0009880	174	0.066
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.066
positive regulation of cellular amine metabolic process	GO:0033240	0	0.066
regulation of phosphorus metabolic process	GO:0051174	210	0.065	Human Mouse
regulation of cellular response to stress	GO:0080135	89	0.065	Human Mouse
positive regulation of biosynthetic process	GO:0009891	316	0.065	Human Mouse
negative regulation of cellular response to growth factor stimulus	GO:0090288	6	0.064
regulation of cell cycle process	GO:0010564	181	0.064
central nervous system development	GO:0007417	201	0.064
intrinsic apoptotic signaling pathway	GO:0097193	16	0.063	Mouse
stem cell differentiation	GO:0048863	117	0.063
muscle system process	GO:0003012	21	0.062
positive regulation of cell differentiation	GO:0045597	64	0.062
regulation of cell development	GO:0060284	215	0.062
endocytosis	GO:0006897	310	0.062
neuroblast division	GO:0055057	35	0.062
cellular response to carbohydrate stimulus	GO:0071322	4	0.062
regulation of cellular amine metabolic process	GO:0033238	3	0.061
apposition of dorsal and ventral imaginal disc derived wing surfaces	GO:0007475	15	0.060
gliogenesis	GO:0042063	80	0.059
response to wounding	GO:0009611	94	0.059
negative regulation of transferase activity	GO:0051348	18	0.059	Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.059
telencephalon development	GO:0021537	2	0.059
positive regulation of catalytic activity	GO:0043085	118	0.058
response to hexose	GO:0009746	3	0.057
regulation of protein transport	GO:0051223	57	0.057
cellular response to fibroblast growth factor stimulus	GO:0044344	10	0.057
dorsal ventral axis specification	GO:0009950	66	0.057
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.056	Human Mouse
cell activation	GO:0001775	9	0.056
regulation of cytoplasmic transport	GO:1903649	47	0.056
establishment of planar polarity	GO:0001736	87	0.055
ribose phosphate metabolic process	GO:0019693	145	0.055
leg disc morphogenesis	GO:0007478	80	0.055
positive regulation of response to external stimulus	GO:0032103	44	0.054
positive regulation of protein modification process	GO:0031401	58	0.054	Mouse
chemotaxis	GO:0006935	249	0.054
gonad development	GO:0008406	50	0.054
rhythmic process	GO:0048511	106	0.053
negative regulation of kinase activity	GO:0033673	16	0.053	Mouse
positive regulation of cell development	GO:0010720	61	0.053
protein targeting to nucleus	GO:0044744	51	0.052
axon choice point recognition	GO:0016198	26	0.052
rna processing	GO:0006396	147	0.052
immune effector process	GO:0002252	98	0.051
gravitaxis	GO:0042332	26	0.051
positive regulation of signal transduction	GO:0009967	223	0.051
peptidyl amino acid modification	GO:0018193	105	0.051	Mouse
response to oxygen containing compound	GO:1901700	200	0.051
secondary metabolic process	GO:0019748	75	0.050
multi organism behavior	GO:0051705	175	0.050
positive regulation of cellular component biogenesis	GO:0044089	80	0.049
renal filtration	GO:0097205	7	0.049
negative regulation of cell death	GO:0060548	81	0.049	Human Mouse
renal system development	GO:0072001	72	0.049
protein targeting	GO:0006605	64	0.048
cell junction organization	GO:0034330	57	0.048
neuronal stem cell division	GO:0036445	35	0.048
imaginal disc derived leg morphogenesis	GO:0007480	80	0.048
antimicrobial humoral response	GO:0019730	99	0.048
regulation of photoreceptor cell differentiation	GO:0046532	34	0.048
response to heat	GO:0009408	63	0.048
regulation of multicellular organismal development	GO:2000026	414	0.048	Human Zebrafish
regulation of stem cell proliferation	GO:0072091	40	0.048
brain development	GO:0007420	120	0.047
amine metabolic process	GO:0009308	12	0.047
positive regulation of cellular catabolic process	GO:0031331	95	0.047
oocyte differentiation	GO:0009994	145	0.047
anterior posterior pattern specification	GO:0009952	136	0.047	Mouse
negative regulation of immune system process	GO:0002683	50	0.047
regulation of catabolic process	GO:0009894	170	0.046
multicellular organismal aging	GO:0010259	140	0.046	Worm
negative regulation of phosphate metabolic process	GO:0045936	45	0.045	Mouse
erk1 and erk2 cascade	GO:0070371	39	0.045
neuroblast differentiation	GO:0014016	29	0.045
nuclear import	GO:0051170	51	0.045
kidney development	GO:0001822	3	0.044
negative regulation of nervous system development	GO:0051961	92	0.043
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.043
regulation of production of molecular mediator of immune response	GO:0002700	44	0.043
imaginal disc derived wing vein specification	GO:0007474	48	0.042
regulation of anatomical structure morphogenesis	GO:0022603	242	0.042	Human
reproductive structure development	GO:0048608	74	0.042
contractile actin filament bundle assembly	GO:0030038	1	0.042
rna interference	GO:0016246	27	0.042
modification dependent protein catabolic process	GO:0019941	78	0.042
motor neuron axon guidance	GO:0008045	58	0.042
meiotic cell cycle	GO:0051321	171	0.042
positive regulation of protein phosphorylation	GO:0001934	34	0.041	Mouse
regulation of cell migration	GO:0030334	22	0.041
establishment of protein localization	GO:0045184	163	0.041
gene silencing	GO:0016458	138	0.041
positive regulation of peptidase activity	GO:0010952	29	0.040
regulation of cellular ketone metabolic process	GO:0010565	3	0.040
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.040
regulation of multi organism process	GO:0043900	131	0.040
single organism behavior	GO:0044708	391	0.040	Mouse
female gonad development	GO:0008585	12	0.040
peripheral nervous system development	GO:0007422	52	0.040
establishment of spindle orientation	GO:0051294	18	0.040
imaginal disc derived wing hair site selection	GO:0035320	4	0.039
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	11	0.039	Mouse
regulation of response to biotic stimulus	GO:0002831	63	0.039
renal tubule morphogenesis	GO:0061333	44	0.039
nephron epithelium development	GO:0072009	3	0.039
spinal cord development	GO:0021510	1	0.039
negative regulation of multicellular organismal process	GO:0051241	142	0.038
rna splicing	GO:0008380	83	0.038
regulation of transferase activity	GO:0051338	58	0.038	Mouse
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.038
protein localization to organelle	GO:0033365	82	0.037
regulation of heart contraction	GO:0008016	21	0.037
actin filament bundle organization	GO:0061572	28	0.037
dendrite development	GO:0016358	204	0.036
regulation of embryonic development	GO:0045995	68	0.036
response to fibroblast growth factor	GO:0071774	10	0.035
endoderm formation	GO:0001706	3	0.035
positive regulation of r7 cell differentiation	GO:0045678	7	0.035
sex differentiation	GO:0007548	81	0.035
smad protein import into nucleus	GO:0007184	11	0.035
embryonic organ morphogenesis	GO:0048562	5	0.035	Mouse
synaptic transmission	GO:0007268	288	0.035
regulation of cellular catabolic process	GO:0031329	157	0.035
body morphogenesis	GO:0010171	2	0.034
stress fiber assembly	GO:0043149	6	0.034
glial cell differentiation	GO:0010001	35	0.034
stem cell proliferation	GO:0072089	88	0.034
actin cytoskeleton reorganization	GO:0031532	22	0.034
wing disc dorsal ventral pattern formation	GO:0048190	47	0.033
epithelial tube morphogenesis	GO:0060562	88	0.033
regulation of actin cytoskeleton organization	GO:0032956	42	0.033
regulation of mrna processing	GO:0050684	71	0.033
protein modification by small protein conjugation	GO:0032446	79	0.033
cellular amino acid metabolic process	GO:0006520	61	0.033
positive regulation of cell adhesion	GO:0045785	10	0.033
negative regulation of ras protein signal transduction	GO:0046580	13	0.032
regulation of translation	GO:0006417	56	0.032
leg disc development	GO:0035218	92	0.032
nephron tubule development	GO:0072080	3	0.032
cortical actin cytoskeleton organization	GO:0030866	24	0.032
regulation of blood circulation	GO:1903522	21	0.032
cellular carbohydrate metabolic process	GO:0044262	22	0.032
positive regulation of wnt signaling pathway	GO:0030177	25	0.032
chromatin remodeling	GO:0006338	72	0.032
positive regulation of cell cycle	GO:0045787	43	0.031
organic cyclic compound catabolic process	GO:1901361	168	0.031
kidney morphogenesis	GO:0060993	3	0.031
positive regulation of protein transport	GO:0051222	37	0.031
r7 cell fate commitment	GO:0007465	12	0.031
ubiquitin dependent protein catabolic process	GO:0006511	78	0.031
gene silencing by rna	GO:0031047	57	0.030
cellular response to extracellular stimulus	GO:0031668	64	0.030
protein complex assembly	GO:0006461	200	0.030
cellular chemical homeostasis	GO:0055082	40	0.030
regulation of epithelial cell differentiation	GO:0030856	4	0.030	Zebrafish
response to ketone	GO:1901654	34	0.030
wound healing	GO:0042060	75	0.030
imaginal disc derived wing hair outgrowth	GO:0035318	1	0.030
dorsal ventral axon guidance	GO:0033563	2	0.030
ventral cord development	GO:0007419	16	0.029
establishment of ommatidial planar polarity	GO:0042067	49	0.029
regulation of cell cell adhesion	GO:0022407	21	0.029
negative regulation of apoptotic process	GO:0043066	63	0.029	Human Mouse
nephron epithelium morphogenesis	GO:0072088	3	0.028
stem cell fate commitment	GO:0048865	25	0.028
stem cell fate specification	GO:0048866	2	0.028
hair cell differentiation	GO:0035315	47	0.028
nephron tubule morphogenesis	GO:0072078	3	0.028
heart process	GO:0003015	37	0.027
cardiac cell fate commitment	GO:0060911	17	0.027
response to hormone	GO:0009725	45	0.027
immune response regulating signaling pathway	GO:0002764	2	0.027
response to nitrogen compound	GO:1901698	90	0.027
cell cell junction organization	GO:0045216	55	0.027
neuroblast proliferation	GO:0007405	74	0.027
defense response to other organism	GO:0098542	225	0.027
production of molecular mediator of immune response	GO:0002440	46	0.026
regulation of protein catabolic process	GO:0042176	55	0.026
embryonic hemopoiesis	GO:0035162	26	0.026
cellular response to external stimulus	GO:0071496	66	0.026

hipk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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