IMP: Integrative Multi-species Prediction

Drosophila melanogaster

65 known processes

fab1 (Dmel_CG6355)

CG6355 gene product from transcript CG6355-RA

(Aliases: fab-1,Fab1,PIKfyve,Dmel\CG6355,EG:52C10.5,CG6355)

FLYBASE: FBgn0028741
Entrez: 37033
UniProtKB: C7LAB6
UniProtKB: O96838

Process Predictions
Disease Predictions

fab1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
regulation of multicellular organismal development	GO:2000026	414	0.290
negative regulation of organ growth	GO:0046621	15	0.247
single organism intracellular transport	GO:1902582	207	0.139
regulation of imaginal disc growth	GO:0045570	26	0.107
intracellular transport	GO:0046907	228	0.103
embryonic morphogenesis	GO:0048598	206	0.101
vesicle mediated transport	GO:0016192	381	0.097
imaginal disc growth	GO:0007446	37	0.095
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.094
tube development	GO:0035295	244	0.090
compound eye development	GO:0048749	307	0.089
eye morphogenesis	GO:0048592	260	0.086
catabolic process	GO:0009056	409	0.085
chromosome organization	GO:0051276	360	0.081
regulation of growth	GO:0040008	233	0.081
organonitrogen compound metabolic process	GO:1901564	318	0.078
compound eye morphogenesis	GO:0001745	249	0.077
cell cycle phase transition	GO:0044770	140	0.075
regulation of developmental growth	GO:0048638	174	0.074
axis specification	GO:0009798	167	0.074
negative regulation of imaginal disc growth	GO:0045571	8	0.065
regulation of proteolysis	GO:0030162	87	0.064
endosomal transport	GO:0016197	44	0.063
protein complex assembly	GO:0006461	200	0.062
cellularization	GO:0007349	90	0.061
negative regulation of rna metabolic process	GO:0051253	251	0.060
response to bacterium	GO:0009617	198	0.060
response to organic substance	GO:0010033	284	0.059
negative regulation of cell cycle process	GO:0010948	109	0.054
proteolysis	GO:0006508	192	0.053
tube morphogenesis	GO:0035239	191	0.053
eye development	GO:0001654	323	0.053
protein modification process	GO:0036211	438	0.053
cellular macromolecule localization	GO:0070727	220	0.052
regulation of cell proliferation	GO:0042127	163	0.052
regulation of cell cycle	GO:0051726	291	0.051
tissue morphogenesis	GO:0048729	297	0.051
single organism membrane fusion	GO:0044801	42	0.051
cellular macromolecule catabolic process	GO:0044265	136	0.049
cellular protein modification process	GO:0006464	438	0.049
nucleoside triphosphate metabolic process	GO:0009141	120	0.049
small molecule metabolic process	GO:0044281	305	0.049
single organism catabolic process	GO:0044712	228	0.048
organic substance catabolic process	GO:1901575	308	0.048
regulation of apoptotic process	GO:0042981	130	0.047
mitotic cell cycle phase transition	GO:0044772	138	0.046
negative regulation of signal transduction	GO:0009968	206	0.046
negative regulation of developmental growth	GO:0048640	64	0.044
regulation of cellular response to stress	GO:0080135	89	0.043
organelle fusion	GO:0048284	46	0.043
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.043
purine containing compound metabolic process	GO:0072521	155	0.042
negative regulation of transcription dna templated	GO:0045892	237	0.042
nuclear division	GO:0000280	332	0.042
regulation of intracellular signal transduction	GO:1902531	236	0.041
intracellular signal transduction	GO:0035556	300	0.041
regionalization	GO:0003002	416	0.040
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.040
positive regulation of peptidase activity	GO:0010952	29	0.040
cell growth	GO:0016049	108	0.040
segmentation	GO:0035282	207	0.039
ribose phosphate metabolic process	GO:0019693	145	0.039
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.039
establishment or maintenance of polarity of follicular epithelium	GO:0016334	26	0.039
purine nucleotide catabolic process	GO:0006195	109	0.039
cytoplasmic transport	GO:0016482	130	0.038
protein localization	GO:0008104	284	0.038
spermatid development	GO:0007286	98	0.038
protein transport	GO:0015031	155	0.037
protein modification by small protein conjugation or removal	GO:0070647	106	0.037
purine containing compound catabolic process	GO:0072523	112	0.036
nucleoside phosphate metabolic process	GO:0006753	162	0.036
regulation of endopeptidase activity	GO:0052548	36	0.036
organophosphate metabolic process	GO:0019637	195	0.036
nucleoside phosphate catabolic process	GO:1901292	110	0.035
regulation of neural precursor cell proliferation	GO:2000177	35	0.035
endocytosis	GO:0006897	310	0.034
negative regulation of growth	GO:0045926	84	0.034
pigmentation	GO:0043473	75	0.034
nucleoside catabolic process	GO:0009164	112	0.034
negative regulation of cell cycle	GO:0045786	116	0.034
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.034
nucleotide catabolic process	GO:0009166	109	0.033
response to other organism	GO:0051707	293	0.033
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.033
purine nucleoside catabolic process	GO:0006152	112	0.033
purine nucleotide metabolic process	GO:0006163	146	0.033
cellular amino acid metabolic process	GO:0006520	61	0.032
spermatid differentiation	GO:0048515	114	0.032
establishment of protein localization to organelle	GO:0072594	62	0.032
organophosphate biosynthetic process	GO:0090407	46	0.032
organ growth	GO:0035265	56	0.031
nucleoside triphosphate catabolic process	GO:0009143	108	0.031
oxoacid metabolic process	GO:0043436	103	0.031
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.030
defense response to bacterium	GO:0042742	178	0.030
mitotic sister chromatid segregation	GO:0000070	87	0.030
lysosomal transport	GO:0007041	13	0.030
negative regulation of gene expression epigenetic	GO:0045814	77	0.030
regulation of mitotic cell cycle	GO:0007346	190	0.029
nucleotide metabolic process	GO:0009117	161	0.029
neurological system process	GO:0050877	358	0.029
forebrain development	GO:0030900	2	0.029
cell proliferation	GO:0008283	299	0.029
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.028
membrane fusion	GO:0061025	42	0.028
membrane organization	GO:0061024	112	0.028
ribonucleoside catabolic process	GO:0042454	112	0.028
sister chromatid segregation	GO:0000819	92	0.028
digestive tract development	GO:0048565	149	0.027
eye photoreceptor cell differentiation	GO:0001754	145	0.027
body morphogenesis	GO:0010171	2	0.027
establishment or maintenance of cell polarity	GO:0007163	167	0.026
carbohydrate derivative catabolic process	GO:1901136	118	0.026
positive regulation of response to stimulus	GO:0048584	323	0.026
regulation of gene expression epigenetic	GO:0040029	128	0.026
sensory organ morphogenesis	GO:0090596	260	0.026
chromatin silencing	GO:0006342	76	0.025
multicellular organismal aging	GO:0010259	140	0.025
protein processing	GO:0016485	68	0.025
purine nucleoside metabolic process	GO:0042278	127	0.025
response to oxygen containing compound	GO:1901700	200	0.025
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.025
mitotic cell cycle embryonic	GO:0045448	38	0.025
regulation of organ growth	GO:0046620	42	0.024
nucleoside metabolic process	GO:0009116	127	0.024
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.024
organic acid metabolic process	GO:0006082	103	0.024
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.024
developmental growth	GO:0048589	280	0.024
response to lipopolysaccharide	GO:0032496	4	0.024
programmed cell death	GO:0012501	257	0.023
establishment of localization in cell	GO:0051649	402	0.023
growth	GO:0040007	359	0.023
defense response to other organism	GO:0098542	225	0.023
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.023
purine ribonucleotide metabolic process	GO:0009150	145	0.023
immune system process	GO:0002376	347	0.023
ribonucleotide catabolic process	GO:0009261	109	0.023
regulation of cell development	GO:0060284	215	0.023
regulation of hydrolase activity	GO:0051336	97	0.023
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.023
cell death	GO:0008219	279	0.023
epithelial cell development	GO:0002064	274	0.022
olfactory behavior	GO:0042048	97	0.022
protein maturation	GO:0051604	71	0.022
g protein coupled receptor signaling pathway	GO:0007186	136	0.022
posttranscriptional regulation of gene expression	GO:0010608	145	0.022
muscle structure development	GO:0061061	224	0.022
regulation of catabolic process	GO:0009894	170	0.022
determination of adult lifespan	GO:0008340	137	0.022
nucleobase containing small molecule metabolic process	GO:0055086	174	0.022
ribonucleotide metabolic process	GO:0009259	145	0.022
apoptotic process	GO:0006915	159	0.022
negative regulation of rna biosynthetic process	GO:1902679	240	0.022
establishment of protein localization	GO:0045184	163	0.022
negative regulation of cellular biosynthetic process	GO:0031327	277	0.021
cellular catabolic process	GO:0044248	372	0.021
activation of cysteine type endopeptidase activity	GO:0097202	17	0.021
cellular response to biotic stimulus	GO:0071216	4	0.021
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.021
gastrulation	GO:0007369	70	0.021
regulation of response to external stimulus	GO:0032101	115	0.021
regulation of cell growth	GO:0001558	43	0.020
cellular protein localization	GO:0034613	160	0.020
anterior posterior pattern specification	GO:0009952	136	0.020
organophosphate catabolic process	GO:0046434	112	0.020
mitotic nuclear division	GO:0007067	213	0.020
response to biotic stimulus	GO:0009607	294	0.020
cellular response to lipopolysaccharide	GO:0071222	3	0.020
larval development	GO:0002164	104	0.020
carbohydrate derivative metabolic process	GO:1901135	217	0.020
negative regulation of cellular metabolic process	GO:0031324	382	0.020
heterocycle catabolic process	GO:0046700	166	0.020
locomotory behavior	GO:0007626	176	0.020
glycosyl compound metabolic process	GO:1901657	127	0.019
telencephalon development	GO:0021537	2	0.019
cellular lipid metabolic process	GO:0044255	83	0.019
intracellular protein transport	GO:0006886	104	0.019
negative regulation of developmental process	GO:0051093	201	0.019
aromatic compound catabolic process	GO:0019439	166	0.019
cellular macromolecular complex assembly	GO:0034622	153	0.019
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.019
organonitrogen compound catabolic process	GO:1901565	128	0.019
regulation of multi organism process	GO:0043900	131	0.019
organonitrogen compound biosynthetic process	GO:1901566	117	0.019
regulation of cell cycle phase transition	GO:1901987	130	0.019
stem cell development	GO:0048864	79	0.019
cellular response to dna damage stimulus	GO:0006974	223	0.019
single organism cellular localization	GO:1902580	180	0.019
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.019
regulation of protein metabolic process	GO:0051246	256	0.019
purine ribonucleoside catabolic process	GO:0046130	112	0.018
positive regulation of signal transduction	GO:0009967	223	0.018
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.018
embryonic pattern specification	GO:0009880	174	0.018
spermatogenesis	GO:0007283	200	0.018
response to external biotic stimulus	GO:0043207	293	0.018
chromosome separation	GO:0051304	42	0.018
negative regulation of notch signaling pathway	GO:0045746	41	0.018
chromosome segregation	GO:0007059	157	0.018
protein targeting	GO:0006605	64	0.018
positive regulation of gene expression	GO:0010628	290	0.018
protein localization to organelle	GO:0033365	82	0.018
blastoderm segmentation	GO:0007350	159	0.018
epithelial cell differentiation	GO:0030855	322	0.018
photoreceptor cell differentiation	GO:0046530	170	0.017
carboxylic acid metabolic process	GO:0019752	92	0.017
macromolecular complex assembly	GO:0065003	256	0.017
actin filament organization	GO:0007015	126	0.017
embryonic axis specification	GO:0000578	107	0.017
negative regulation of cell cycle phase transition	GO:1901988	103	0.017
negative regulation of signaling	GO:0023057	219	0.017
morphogenesis of follicular epithelium	GO:0016333	36	0.017
morphogenesis of a polarized epithelium	GO:0001738	93	0.017
endosome transport via multivesicular body sorting pathway	GO:0032509	12	0.017
defense response to gram negative bacterium	GO:0050829	94	0.017
negative regulation of gene expression	GO:0010629	387	0.017
purine ribonucleoside metabolic process	GO:0046128	127	0.016
branching morphogenesis of an epithelial tube	GO:0048754	45	0.016
phosphorylation	GO:0016310	294	0.016
regulation of cellular component biogenesis	GO:0044087	201	0.016
regulation of phosphate metabolic process	GO:0019220	210	0.016
negative regulation of cell death	GO:0060548	81	0.016
negative regulation of response to stimulus	GO:0048585	258	0.016
positive regulation of biosynthetic process	GO:0009891	316	0.016
multi organism behavior	GO:0051705	175	0.016
regulation of programmed cell death	GO:0043067	152	0.016
cellular nitrogen compound catabolic process	GO:0044270	165	0.016
organelle assembly	GO:0070925	198	0.016
digestive system development	GO:0055123	149	0.016
developmental pigmentation	GO:0048066	68	0.016
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.016
regulation of phosphorus metabolic process	GO:0051174	210	0.016
negative regulation of cell communication	GO:0010648	223	0.016
positive regulation of catalytic activity	GO:0043085	118	0.016
nuclear body organization	GO:0030575	6	0.015
pigment metabolic process	GO:0042440	84	0.015
negative regulation of molecular function	GO:0044092	51	0.015
organic cyclic compound catabolic process	GO:1901361	168	0.015
phagocytosis	GO:0006909	215	0.015
retina development in camera type eye	GO:0060041	4	0.015
response to organic cyclic compound	GO:0014070	89	0.015
negative regulation of biosynthetic process	GO:0009890	277	0.015
response to abiotic stimulus	GO:0009628	341	0.015
regulation of catalytic activity	GO:0050790	185	0.015
peptidyl proline modification	GO:0018208	3	0.015
retina morphogenesis in camera type eye	GO:0060042	2	0.015
lateral inhibition	GO:0046331	206	0.015
regulation of molecular function	GO:0065009	217	0.015
mitotic spindle organization	GO:0007052	220	0.015
positive regulation of phosphate metabolic process	GO:0045937	139	0.014
regulation of response to stress	GO:0080134	200	0.014
multi organism reproductive behavior	GO:0044705	121	0.014
covalent chromatin modification	GO:0016569	106	0.014
regulation of cell death	GO:0010941	173	0.014
regulation of mitosis	GO:0007088	56	0.014
protein complex biogenesis	GO:0070271	201	0.014
establishment of vesicle localization	GO:0051650	51	0.014
detection of stimulus	GO:0051606	156	0.014
gtp metabolic process	GO:0046039	72	0.014
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.014
ribonucleoside metabolic process	GO:0009119	127	0.014
compound eye photoreceptor cell differentiation	GO:0001751	140	0.014
protein import	GO:0017038	55	0.014
spindle organization	GO:0007051	253	0.014
negative regulation of multicellular organismal process	GO:0051241	142	0.014
positive regulation of cell communication	GO:0010647	250	0.014
peptide metabolic process	GO:0006518	80	0.014
localization of cell	GO:0051674	257	0.014
regulation of intracellular protein transport	GO:0033157	46	0.014
positive regulation of intracellular signal transduction	GO:1902533	116	0.014
response to endoplasmic reticulum stress	GO:0034976	28	0.014
male gamete generation	GO:0048232	201	0.014
regulation of peptidase activity	GO:0052547	39	0.013
positive regulation of cellular protein metabolic process	GO:0032270	118	0.013
cellular component assembly involved in morphogenesis	GO:0010927	151	0.013
notch signaling pathway	GO:0007219	120	0.013
camera type eye development	GO:0043010	4	0.013
positive regulation of cellular biosynthetic process	GO:0031328	316	0.013
stem cell proliferation	GO:0072089	88	0.013
nucleoside monophosphate metabolic process	GO:0009123	52	0.013
jak stat cascade	GO:0007259	49	0.013
signal transduction by phosphorylation	GO:0023014	107	0.013
chaeta development	GO:0022416	97	0.013
cellular response to organic cyclic compound	GO:0071407	32	0.013
metaphase anaphase transition of cell cycle	GO:0044784	28	0.013
regulation of reproductive process	GO:2000241	54	0.013
nucleobase containing compound catabolic process	GO:0034655	165	0.013
single organism behavior	GO:0044708	391	0.013
cellular response to organic substance	GO:0071310	132	0.013
single organism biosynthetic process	GO:0044711	206	0.013
negative regulation of epithelial cell proliferation	GO:0050680	4	0.013
organic substance transport	GO:0071702	257	0.013
endosome to lysosome transport	GO:0008333	7	0.013
atp metabolic process	GO:0046034	49	0.013
glycosyl compound catabolic process	GO:1901658	112	0.013
wing disc morphogenesis	GO:0007472	344	0.012
homeostatic process	GO:0042592	199	0.012
maintenance of location	GO:0051235	73	0.012
negative regulation of mitotic cell cycle	GO:0045930	109	0.012
secretion	GO:0046903	109	0.012
response to sterol	GO:0036314	34	0.012
cellular amide metabolic process	GO:0043603	80	0.012
mesenchymal cell differentiation	GO:0048762	1	0.012
regulation of epithelial cell differentiation	GO:0030856	4	0.012
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.012
regulation of synapse organization	GO:0050807	110	0.012
dna metabolic process	GO:0006259	227	0.012
stem cell maintenance	GO:0019827	67	0.012
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.012
single organism membrane organization	GO:0044802	93	0.012
positive regulation of phosphorus metabolic process	GO:0010562	139	0.011
protein catabolic process	GO:0030163	101	0.011
mesoderm development	GO:0007498	78	0.011
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.011
regulation of localization	GO:0032879	275	0.011
compound eye photoreceptor development	GO:0042051	78	0.011
sex differentiation	GO:0007548	81	0.011
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.011
cellular response to chemical stimulus	GO:0070887	199	0.011
negative regulation of catalytic activity	GO:0043086	42	0.011
regulation of protein complex assembly	GO:0043254	42	0.011
dorsal ventral pattern formation	GO:0009953	133	0.011
regulation of organelle organization	GO:0033043	196	0.011
dephosphorylation	GO:0016311	51	0.011
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.011
synaptic vesicle localization	GO:0097479	53	0.011
death	GO:0016265	284	0.011
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.011
cellular response to external stimulus	GO:0071496	66	0.011
positive regulation of phosphorylation	GO:0042327	87	0.011
response to starvation	GO:0042594	97	0.011
regulation of ras protein signal transduction	GO:0046578	93	0.011
mesenchymal cell development	GO:0014031	1	0.011
regulation of embryonic development	GO:0045995	68	0.011
rhythmic behavior	GO:0007622	76	0.010
regulation of sister chromatid segregation	GO:0033045	28	0.010
nephron tubule development	GO:0072080	3	0.010
mitotic cell cycle checkpoint	GO:0007093	88	0.010
nephron epithelium development	GO:0072009	3	0.010
mitotic sister chromatid separation	GO:0051306	30	0.010
regulation of cell cycle process	GO:0010564	181	0.010
cellular response to molecule of bacterial origin	GO:0071219	3	0.010
protein modification by small protein conjugation	GO:0032446	79	0.010
eye pigmentation	GO:0048069	43	0.010
molting cycle chitin based cuticle	GO:0007591	56	0.010
negative regulation of apoptotic process	GO:0043066	63	0.010
rna processing	GO:0006396	147	0.010
positive regulation of protein metabolic process	GO:0051247	128	0.010
organelle fission	GO:0048285	340	0.010
kidney epithelium development	GO:0072073	3	0.010
regulation of cellular protein metabolic process	GO:0032268	243	0.010
negative regulation of intracellular signal transduction	GO:1902532	57	0.010
response to extracellular stimulus	GO:0009991	116	0.010
ameboidal type cell migration	GO:0001667	151	0.010

fab1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.048
disease of cellular proliferation	DOID:14566	0.021
disease of metabolism	DOID:0014667	0.019
organ system cancer	DOID:0050686	0.018
cancer	DOID:162	0.018

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