Drosophila melanogaster

48 known processes

fh (Dmel_CG8971)

frataxin homolog

(Aliases: Dmel\CG8971,dfh,DFH,X25,CG8971,BcDNA:AT09528,Dfh)

fh biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
circadian rhythmGO:00076231050.355
regulation of immune responseGO:00507761180.226
response to external biotic stimulusGO:00432072930.219
defense response to bacteriumGO:00427421780.179
neurological system processGO:00508773580.177
response to oxidative stressGO:0006979860.160
agingGO:00075681430.142
Worm
response to biotic stimulusGO:00096072940.134
defense response to other organismGO:00985422250.131
regulation of response to stressGO:00801342000.122
negative regulation of macromolecule biosynthetic processGO:00105582700.117
multicellular organismal agingGO:00102591400.113
Worm
positive regulation of nitrogen compound metabolic processGO:00511733540.110
response to radiationGO:00093141550.100
rhythmic processGO:00485111060.094
regulation of defense responseGO:00313471020.084
locomotory behaviorGO:00076261760.083
mitochondrion organizationGO:0007005650.083
negative regulation of neuron deathGO:1901215180.080
response to oxygen containing compoundGO:19017002000.079
immune response activating signal transductionGO:000275720.077
regulation of cell deathGO:00109411730.075
regulation of circadian rhythmGO:0042752490.074
response to abiotic stimulusGO:00096283410.071
neuron deathGO:0070997270.071
response to bacteriumGO:00096171980.070
single organism behaviorGO:00447083910.068
detection of stimulusGO:00516061560.066
organonitrogen compound metabolic processGO:19015643180.064
regulation of neuron deathGO:1901214260.063
negative regulation of defense responseGO:0031348350.060
positive regulation of response to stimulusGO:00485843230.059
determination of adult lifespanGO:00083401370.058
Worm
phagocytosisGO:00069092150.058
response to other organismGO:00517072930.057
regulation of transcription from rna polymerase ii promoterGO:00063573780.057
sensory organ morphogenesisGO:00905962600.057
cellular response to oxidative stressGO:0034599280.057
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.056
taxisGO:00423303040.056
regulation of programmed cell deathGO:00430671520.056
endocytosisGO:00068973100.055
vesicle mediated transportGO:00161923810.055
immune effector processGO:0002252980.053
ion transmembrane transportGO:00342201220.053
localization of cellGO:00516742570.052
immune responseGO:00069552460.051
g protein coupled receptor signaling pathwayGO:00071861360.051
organic substance catabolic processGO:19015753080.050
immune system processGO:00023763470.050
regulation of innate immune responseGO:0045088710.049
negative regulation of cell deathGO:0060548810.049
establishment of localization in cellGO:00516494020.049
regulation of photoreceptor cell differentiationGO:0046532340.048
positive regulation of signal transductionGO:00099672230.045
response to hydrogen peroxideGO:0042542110.044
positive regulation of macromolecule biosynthetic processGO:00105572830.043
organelle fissionGO:00482853400.042
regulation of catabolic processGO:00098941700.041
regulation of intracellular signal transductionGO:19025312360.041
macromolecule catabolic processGO:00090571610.041
catecholamine biosynthetic processGO:004242330.041
positive regulation of nucleic acid templated transcriptionGO:19035082660.041
defense response to gram negative bacteriumGO:0050829940.040
nucleobase containing small molecule metabolic processGO:00550861740.040
regulation of neurogenesisGO:00507671580.039
ion transportGO:00068111450.039
regulation of cell cycleGO:00517262910.039
negative regulation of immune responseGO:0050777390.039
innate immune response activating signal transductionGO:000275820.039
cellular response to dna damage stimulusGO:00069742230.038
transmembrane transportGO:00550851390.038
small molecule metabolic processGO:00442813050.037
negative regulation of cellular metabolic processGO:00313243820.037
rhythmic behaviorGO:0007622760.037
cellular amide metabolic processGO:0043603800.037
positive regulation of cellular biosynthetic processGO:00313283160.037
mapk cascadeGO:00001651070.036
negative regulation of programmed cell deathGO:0043069720.035
negative regulation of nitrogen compound metabolic processGO:00511722650.035
cellular catabolic processGO:00442483720.035
regulation of immune system processGO:00026821760.035
positive regulation of transcription dna templatedGO:00458932660.034
response to virusGO:0009615280.033
innate immune responseGO:00450871440.033
cellular response to reactive oxygen speciesGO:0034614140.033
defense responseGO:00069523000.032
immune response regulating signaling pathwayGO:000276420.032
purine ribonucleoside metabolic processGO:00461281270.032
single organism biosynthetic processGO:00447112060.032
adult behaviorGO:00305341370.032
single organism cellular localizationGO:19025801800.031
positive regulation of rna metabolic processGO:00512542710.031
dna damage checkpointGO:0000077780.030
regulation of transportGO:00510491810.030
long term memoryGO:0007616620.030
circadian behaviorGO:0048512760.030
epithelial cell differentiationGO:00308553220.030
camera type eye developmentGO:004301040.030
transcription from rna polymerase ii promoterGO:00063663680.030
axon guidanceGO:00074112330.029
regulation of response to external stimulusGO:00321011150.029
cellular response to oxygen containing compoundGO:1901701790.029
cellular response to chemical stimulusGO:00708871990.029
positive regulation of nucleobase containing compound metabolic processGO:00459353320.028
pattern recognition receptor signaling pathwayGO:000222120.028
chemotaxisGO:00069352490.028
central nervous system developmentGO:00074172010.028
negative regulation of immune system processGO:0002683500.027
regulation of cellular amino acid metabolic processGO:000652100.027
negative regulation of apoptotic processGO:0043066630.027
locomotor rhythmGO:0045475560.027
activation of innate immune responseGO:000221840.027
photoreceptor cell differentiationGO:00465301700.027
deathGO:00162652840.027
sensory perceptionGO:00076001960.026
female meiotic divisionGO:0007143700.026
response to oxygen radicalGO:000030530.026
Worm
cellular response to organonitrogen compoundGO:0071417360.026
response to starvationGO:0042594970.026
organonitrogen compound biosynthetic processGO:19015661170.025
regulation of cellular amine metabolic processGO:003323830.025
positive regulation of gene expressionGO:00106282900.025
regulation of apoptotic processGO:00429811300.025
organophosphate metabolic processGO:00196371950.025
homeostatic processGO:00425921990.024
regulation of autophagyGO:0010506620.024
positive regulation of cell communicationGO:00106472500.024
purine ribonucleoside triphosphate metabolic processGO:00092051190.024
catabolic processGO:00090564090.023
positive regulation of signalingGO:00230562430.023
mrna catabolic processGO:0006402330.023
positive regulation of rna biosynthetic processGO:19026802660.023
cellular amino acid metabolic processGO:0006520610.023
eye morphogenesisGO:00485922600.023
negative regulation of cellular response to oxidative stressGO:190040810.023
response to lipopolysaccharideGO:003249640.023
carbohydrate derivative metabolic processGO:19011352170.023
negative regulation of cell cycle phase transitionGO:19019881030.023
appendage morphogenesisGO:00351073970.023
positive regulation of molecular functionGO:00440931360.023
columnar cuboidal epithelial cell developmentGO:00020662490.022
regulation of mitotic cell cycleGO:00073461900.022
phosphorylationGO:00163102940.022
negative regulation of response to oxidative stressGO:190288310.022
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.021
organic substance transportGO:00717022570.021
ribonucleotide metabolic processGO:00092591450.021
response to extracellular stimulusGO:00099911160.020
single organism catabolic processGO:00447122280.020
negative regulation of transcription dna templatedGO:00458922370.020
cellular nitrogen compound catabolic processGO:00442701650.020
cell deathGO:00082192790.020
eye photoreceptor cell differentiationGO:00017541450.020
negative regulation of mitotic cell cycleGO:00459301090.020
negative regulation of gene expressionGO:00106293870.019
negative regulation of cell differentiationGO:00455961430.019
negative regulation of response to stimulusGO:00485852580.019
cellular amine metabolic processGO:0044106120.019
positive regulation of biosynthetic processGO:00098913160.019
positive regulation of immune responseGO:0050778630.019
cell type specific apoptotic processGO:0097285380.019
negative regulation of nervous system developmentGO:0051961920.019
ameboidal type cell migrationGO:00016671510.019
chromatin organizationGO:00063252070.019
cellular response to nitrogen compoundGO:1901699510.019
regulation of response to oxidative stressGO:190288240.019
regulation of mitotic cell cycle phase transitionGO:19019901300.018
ribonucleoside metabolic processGO:00091191270.018
regulation of cellular response to oxidative stressGO:190040740.018
covalent chromatin modificationGO:00165691060.018
positive regulation of macromolecule metabolic processGO:00106044050.018
regulation of catalytic activityGO:00507901850.018
cellular lipid metabolic processGO:0044255830.018
synaptic transmissionGO:00072682880.018
protein modification by small protein conjugationGO:0032446790.018
regulation of cell sizeGO:0008361630.018
rna processingGO:00063961470.018
protein transportGO:00150311550.018
regulation of nervous system developmentGO:00519602480.017
response to nitrogen compoundGO:1901698900.017
metal ion transportGO:0030001740.017
cardiovascular system developmentGO:0072358820.017
regulation of molecular functionGO:00650092170.017
negative regulation of cellular biosynthetic processGO:00313272770.017
cellular response to organic substanceGO:00713101320.017
nuclear divisionGO:00002803320.017
negative regulation of intracellular signal transductionGO:1902532570.017
intracellular signal transductionGO:00355563000.017
cellular response to extracellular stimulusGO:0031668640.017
cellular response to starvationGO:0009267610.017
negative regulation of nucleobase containing compound metabolic processGO:00459342610.017
nucleoside metabolic processGO:00091161270.017
response to organonitrogen compoundGO:0010243750.016
response to gravityGO:0009629260.016
cell cycle checkpointGO:0000075950.016
regulation of phosphate metabolic processGO:00192202100.016
negative regulation of cell cycleGO:00457861160.016
pigment metabolic processGO:0042440840.016
cellular response to lipopolysaccharideGO:007122230.016
carboxylic acid metabolic processGO:0019752920.016
single organism carbohydrate metabolic processGO:0044723720.016
cellular response to ionizing radiationGO:0071479150.016
negative regulation of biosynthetic processGO:00098902770.016
compound eye morphogenesisGO:00017452490.016
learning or memoryGO:00076111410.016
mitotic dna integrity checkpointGO:0044774750.016
negative regulation of nucleic acid templated transcriptionGO:19035072400.016
purine ribonucleotide metabolic processGO:00091501450.016
response to heatGO:0009408630.016
protein modification processGO:00362114380.016
ribonucleoside triphosphate metabolic processGO:00091991190.016
negative regulation of developmental processGO:00510932010.016
response to ionizing radiationGO:0010212320.016
regulation of cellular component sizeGO:0032535980.016
forebrain developmentGO:003090020.015
response to alcoholGO:0097305950.015
response to organic substanceGO:00100332840.015
peptidyl amino acid modificationGO:00181931050.015
secretionGO:00469031090.015
nucleoside phosphate metabolic processGO:00067531620.015
response to reactive oxygen speciesGO:0000302240.015
positive regulation of defense responseGO:0031349590.015
stem cell differentiationGO:00488631170.015
regulation of notch signaling pathwayGO:00085931000.015
ribose phosphate metabolic processGO:00196931450.015
eye developmentGO:00016543230.015
epithelial cell migrationGO:00106311480.014
epithelial cell developmentGO:00020642740.014
organic acid metabolic processGO:00060821030.014
response to endogenous stimulusGO:00097191190.014
catechol containing compound biosynthetic processGO:000971330.014
negative regulation of cell cycle processGO:00109481090.014
peptide metabolic processGO:0006518800.014
dna integrity checkpointGO:0031570810.014
amine metabolic processGO:0009308120.014
positive regulation of immune system processGO:0002684680.014
positive regulation of phosphorus metabolic processGO:00105621390.014
gliogenesisGO:0042063800.014
single organism intracellular transportGO:19025822070.014
negative regulation of innate immune responseGO:0045824300.014
compound eye photoreceptor cell differentiationGO:00017511400.014
growthGO:00400073590.014
Worm
secretion by cellGO:00329401010.013
modification dependent macromolecule catabolic processGO:0043632790.013
carbohydrate metabolic processGO:0005975820.013
cellular response to peptideGO:1901653280.013
regulation of cellular response to stressGO:0080135890.013
response to light stimulusGO:00094161240.013
cell cycle phase transitionGO:00447701400.013
oxoacid metabolic processGO:00434361030.013
cellular response to hydrogen peroxideGO:007030170.013
jnk cascadeGO:0007254500.013
organelle assemblyGO:00709251980.013
molting cycle processGO:0022404290.012
nucleobase containing compound catabolic processGO:00346551650.012
neuron projection guidanceGO:00974852410.012
purine nucleoside metabolic processGO:00422781270.012
inorganic ion transmembrane transportGO:0098660730.012
negative regulation of rna biosynthetic processGO:19026792400.012
aromatic compound catabolic processGO:00194391660.012
response to superoxideGO:000030330.012
Worm
columnar cuboidal epithelial cell differentiationGO:00020652560.012
signal transduction by phosphorylationGO:00230141070.012
cellular response to external stimulusGO:0071496660.012
defense response to virusGO:0051607230.012
neuropeptide signaling pathwayGO:0007218450.012
cellular response to hormone stimulusGO:0032870440.012
regulation of cell differentiationGO:00455953020.012
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.012
tissue migrationGO:00901301550.012
cell migrationGO:00164772380.012
chromosome segregationGO:00070591570.012
reactive oxygen species metabolic processGO:0072593220.012
purine containing compound metabolic processGO:00725211550.012
carbohydrate biosynthetic processGO:0016051170.012
dendrite developmentGO:00163582040.012
regulation of immune effector processGO:0002697520.012
positive regulation of peptidyl tyrosine phosphorylationGO:005073140.012
lipid metabolic processGO:00066291210.011
positive regulation of cell motilityGO:200014730.011
purine nucleotide metabolic processGO:00061631460.011
biological adhesionGO:00226101380.011
response to nutrient levelsGO:00316671140.011
proteasomal protein catabolic processGO:0010498590.011
segmentationGO:00352822070.011
cellular response to molecule of bacterial originGO:007121930.011
generation of precursor metabolites and energyGO:0006091420.011
cellular response to insulin stimulusGO:0032869280.011
posttranscriptional regulation of gene expressionGO:00106081450.011
circulatory system developmentGO:0072359820.011
negative regulation of signal transductionGO:00099682060.011
negative regulation of rna metabolic processGO:00512532510.011
positive regulation of cell deathGO:0010942690.011
positive regulation of intracellular signal transductionGO:19025331160.011
cellular response to biotic stimulusGO:007121640.011
oxidation reduction processGO:00551141230.011
membrane organizationGO:00610241120.011
microtubule polymerization or depolymerizationGO:0031109390.011
positive regulation of cellular component biogenesisGO:0044089800.011
stress activated mapk cascadeGO:0051403520.011
regulation of multicellular organismal developmentGO:20000264140.011
oxidative phosphorylationGO:000611990.011
ribonucleoside catabolic processGO:00424541120.011
regulation of phosphorylationGO:00423251470.011
negative regulation of cell communicationGO:00106482230.011
positive regulation of developmental processGO:00510941430.010
Worm
cell agingGO:000756920.010
regulation of cellular localizationGO:00603411360.010
positive regulation of apoptotic signaling pathwayGO:200123540.010
negative regulation of reactive oxygen species metabolic processGO:200037810.010
ncrna metabolic processGO:0034660430.010
carbohydrate derivative catabolic processGO:19011361180.010
response to insulinGO:0032868290.010
regulation of cellular ketone metabolic processGO:001056530.010
regulation of cellular protein metabolic processGO:00322682430.010
intraspecies interaction between organismsGO:005170340.010
camera type eye morphogenesisGO:004859320.010
cellular macromolecule localizationGO:00707272200.010
regulation of insulin receptor signaling pathwayGO:0046626170.010

fh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.034
nervous system diseaseDOID:86300.022
eye diseaseDOID:561400.014
eye and adnexa diseaseDOID:149200.014
sensory system diseaseDOID:005015500.014
cardiovascular system diseaseDOID:128700.014
central nervous system diseaseDOID:33100.013
musculoskeletal system diseaseDOID:1700.013
disease of cellular proliferationDOID:1456600.012
cancerDOID:16200.012
neurodegenerative diseaseDOID:128900.012
motor neuron diseaseDOID:23100.011