IMP: Integrative Multi-species Prediction

Drosophila melanogaster

142 known processes

Mkk4 (Dmel_CG9738)

MAP kinase kinase 4

(Aliases: 142758_at,mkk4,DMKK4,CT27508,Dmel\CG9738,MKK4,dMKK4,CG9738,JNKK2,Mpk4,SEK1/MKK4,D-MKK4)

Entrez: 41020
FLYBASE: FBgn0024326
UniProtKB: O61444

Process Predictions
Disease Predictions

Mkk4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
axonogenesis	GO:0007409	290	0.621	Fly
axon guidance	GO:0007411	233	0.450
synaptic transmission	GO:0007268	288	0.442	Worm
negative regulation of rna metabolic process	GO:0051253	251	0.425
eye development	GO:0001654	323	0.358
meiotic cell cycle	GO:0051321	171	0.352
taxis	GO:0042330	304	0.324
axon development	GO:0061564	297	0.318	Fly
compound eye morphogenesis	GO:0001745	249	0.305
negative regulation of transcription dna templated	GO:0045892	237	0.296
sensory organ morphogenesis	GO:0090596	260	0.264
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.258
dendrite development	GO:0016358	204	0.254
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.201
spindle organization	GO:0007051	253	0.196
regulation of nervous system development	GO:0051960	248	0.191
chemotaxis	GO:0006935	249	0.177
multi organism behavior	GO:0051705	175	0.169
muscle structure development	GO:0061061	224	0.164	Rat
dendrite morphogenesis	GO:0048813	199	0.156
negative regulation of rna biosynthetic process	GO:1902679	240	0.145
neurological system process	GO:0050877	358	0.145
compound eye photoreceptor development	GO:0042051	78	0.144
regulation of neurogenesis	GO:0050767	158	0.142
neuron projection guidance	GO:0097485	241	0.140
regulation of cell development	GO:0060284	215	0.137
positive regulation of multicellular organismal process	GO:0051240	143	0.135
ras protein signal transduction	GO:0007265	88	0.134
response to organic substance	GO:0010033	284	0.129	Rat
compound eye development	GO:0048749	307	0.129
regionalization	GO:0003002	416	0.128	Zebrafish Fly
mitotic spindle organization	GO:0007052	220	0.121
positive regulation of biosynthetic process	GO:0009891	316	0.118	Rat Fly
regulation of cell differentiation	GO:0045595	302	0.117	Fly
stem cell differentiation	GO:0048863	117	0.113
organelle assembly	GO:0070925	198	0.112
transcription from rna polymerase ii promoter	GO:0006366	368	0.109
organelle fission	GO:0048285	340	0.105
cellular protein modification process	GO:0006464	438	0.103
ribonucleotide metabolic process	GO:0009259	145	0.101
photoreceptor cell differentiation	GO:0046530	170	0.098
regulation of ras protein signal transduction	GO:0046578	93	0.098
organelle localization	GO:0051640	148	0.097
regulation of intracellular signal transduction	GO:1902531	236	0.094
actin filament organization	GO:0007015	126	0.092	Fly
male gamete generation	GO:0048232	201	0.091
regulation of cell cycle	GO:0051726	291	0.090
fertilization	GO:0009566	26	0.089
regulation of neuron differentiation	GO:0045664	103	0.088
endomembrane system organization	GO:0010256	119	0.088
organonitrogen compound metabolic process	GO:1901564	318	0.086
small gtpase mediated signal transduction	GO:0007264	88	0.086
meiotic nuclear division	GO:0007126	151	0.086
segmentation	GO:0035282	207	0.084
stem cell proliferation	GO:0072089	88	0.082
ethanolamine containing compound metabolic process	GO:0042439	4	0.078
macromolecular complex assembly	GO:0065003	256	0.078
positive regulation of cellular biosynthetic process	GO:0031328	316	0.076	Rat Fly
nuclear division	GO:0000280	332	0.074
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.072
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.072
membrane organization	GO:0061024	112	0.071	Fly
amine metabolic process	GO:0009308	12	0.071
eye morphogenesis	GO:0048592	260	0.071
neuron recognition	GO:0008038	101	0.071
determination of adult lifespan	GO:0008340	137	0.071	Fly
negative regulation of cellular biosynthetic process	GO:0031327	277	0.070
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.069	Rat Fly
negative regulation of cell cycle process	GO:0010948	109	0.068
eye photoreceptor cell differentiation	GO:0001754	145	0.067
mitotic nuclear division	GO:0007067	213	0.065
organophosphate metabolic process	GO:0019637	195	0.063
organic substance catabolic process	GO:1901575	308	0.062
dorsal ventral pattern formation	GO:0009953	133	0.061	Zebrafish
protein complex biogenesis	GO:0070271	201	0.060
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.060
compound eye photoreceptor cell differentiation	GO:0001751	140	0.059
protein complex assembly	GO:0006461	200	0.059
regulation of organelle organization	GO:0033043	196	0.059
cellular macromolecule localization	GO:0070727	220	0.058
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.058
protein modification process	GO:0036211	438	0.058
regulation of neuron projection development	GO:0010975	69	0.058
single organism membrane organization	GO:0044802	93	0.057
photoreceptor cell development	GO:0042461	96	0.056
ribonucleoside metabolic process	GO:0009119	127	0.055
meiotic cell cycle process	GO:1903046	132	0.054
eye photoreceptor cell development	GO:0042462	81	0.054
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.053
glycosyl compound catabolic process	GO:1901658	112	0.052
vesicle mediated transport	GO:0016192	381	0.051	Fly
positive regulation of phosphorus metabolic process	GO:0010562	139	0.051
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.050
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.050	Fly
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.049
oocyte differentiation	GO:0009994	145	0.049
regulation of phosphorus metabolic process	GO:0051174	210	0.049
positive regulation of macromolecule metabolic process	GO:0010604	405	0.049
cell recognition	GO:0008037	102	0.049
regulation of cell cycle process	GO:0010564	181	0.049
cellular catabolic process	GO:0044248	372	0.049	Fly
growth	GO:0040007	359	0.048	Rat Fly
brain development	GO:0007420	120	0.048
aromatic compound catabolic process	GO:0019439	166	0.048
synapse assembly	GO:0007416	143	0.048
guanosine containing compound metabolic process	GO:1901068	74	0.048
guanosine containing compound catabolic process	GO:1901069	74	0.047
endocytosis	GO:0006897	310	0.046	Fly
nucleoside phosphate catabolic process	GO:1901292	110	0.045
phosphorylation	GO:0016310	294	0.045
hindgut morphogenesis	GO:0007442	58	0.044
positive regulation of protein metabolic process	GO:0051247	128	0.044
negative regulation of cell development	GO:0010721	62	0.044
embryonic pattern specification	GO:0009880	174	0.044
regulation of molecular function	GO:0065009	217	0.044
cation transport	GO:0006812	110	0.043
dna metabolic process	GO:0006259	227	0.042	Rat
single organism behavior	GO:0044708	391	0.042
intracellular transport	GO:0046907	228	0.042
negative regulation of cell cycle phase transition	GO:1901988	103	0.042
spermatogenesis	GO:0007283	200	0.041
negative regulation of biosynthetic process	GO:0009890	277	0.041
regulation of phosphate metabolic process	GO:0019220	210	0.041
blastoderm segmentation	GO:0007350	159	0.040
cellular response to transforming growth factor beta stimulus	GO:0071560	18	0.040
locomotory behavior	GO:0007626	176	0.040
meiotic chromosome segregation	GO:0045132	59	0.040
cell fate determination	GO:0001709	91	0.040
negative regulation of neurogenesis	GO:0050768	53	0.040
positive regulation of rna metabolic process	GO:0051254	271	0.040	Fly
positive regulation of cellular component organization	GO:0051130	156	0.039
negative regulation of cell differentiation	GO:0045596	143	0.039
synaptic growth at neuromuscular junction	GO:0051124	119	0.039
cell death	GO:0008219	279	0.038	Rat
appendage development	GO:0048736	401	0.038
protein localization	GO:0008104	284	0.038
catabolic process	GO:0009056	409	0.038	Fly
cellular amine metabolic process	GO:0044106	12	0.038
organic cyclic compound catabolic process	GO:1901361	168	0.037
spindle elongation	GO:0051231	83	0.037
establishment of localization in cell	GO:0051649	402	0.037
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.037
regulation of response to stress	GO:0080134	200	0.037
positive regulation of phosphate metabolic process	GO:0045937	139	0.037
leg disc development	GO:0035218	92	0.036
negative regulation of gene expression	GO:0010629	387	0.036	Worm
regulation of mitotic cell cycle	GO:0007346	190	0.036
gland development	GO:0048732	191	0.036
regulation of protein complex assembly	GO:0043254	42	0.036
lipid biosynthetic process	GO:0008610	46	0.036
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.035	Rat Fly
regulation of cell morphogenesis	GO:0022604	163	0.035
mapk cascade	GO:0000165	107	0.035
purine containing compound catabolic process	GO:0072523	112	0.035
sensory perception	GO:0007600	196	0.035
regulation of synapse structure and activity	GO:0050803	128	0.034	Worm
purine nucleotide metabolic process	GO:0006163	146	0.034
response to external biotic stimulus	GO:0043207	293	0.034
negative regulation of nervous system development	GO:0051961	92	0.033
regulation of cell death	GO:0010941	173	0.033	Rat
stem cell development	GO:0048864	79	0.033
single organism catabolic process	GO:0044712	228	0.033
negative regulation of developmental process	GO:0051093	201	0.032
telencephalon development	GO:0021537	2	0.032
mitochondrion organization	GO:0007005	65	0.032
cellular protein localization	GO:0034613	160	0.032
intracellular protein transport	GO:0006886	104	0.032
embryonic development via the syncytial blastoderm	GO:0001700	148	0.032	Fly
regulation of localization	GO:0032879	275	0.032
embryo development ending in birth or egg hatching	GO:0009792	152	0.032	Fly
stem cell maintenance	GO:0019827	67	0.032
positive regulation of response to stimulus	GO:0048584	323	0.032
meiosis i	GO:0007127	59	0.031
carbohydrate derivative catabolic process	GO:1901136	118	0.031
dendrite guidance	GO:0070983	21	0.031
nucleoside triphosphate metabolic process	GO:0009141	120	0.031
cellular protein complex assembly	GO:0043623	71	0.031
regulation of synaptic transmission	GO:0050804	69	0.031
chromatin silencing	GO:0006342	76	0.031
gtp metabolic process	GO:0046039	72	0.031
anterior posterior pattern specification	GO:0009952	136	0.031
single organism biosynthetic process	GO:0044711	206	0.031
regulation of actin filament length	GO:0030832	27	0.031
regulation of cell cycle phase transition	GO:1901987	130	0.030
immune system process	GO:0002376	347	0.030	Fly
response to bacterium	GO:0009617	198	0.030
protein modification by small protein conjugation	GO:0032446	79	0.030
cell growth	GO:0016049	108	0.029	Rat Fly
spermatid development	GO:0007286	98	0.029
cellular macromolecular complex assembly	GO:0034622	153	0.029
cellular response to dna damage stimulus	GO:0006974	223	0.029
nucleobase containing small molecule metabolic process	GO:0055086	174	0.029
defense response to other organism	GO:0098542	225	0.029
protein ubiquitination	GO:0016567	70	0.029
regulation of dendrite morphogenesis	GO:0048814	28	0.029
nucleotide catabolic process	GO:0009166	109	0.028
positive regulation of cellular component biogenesis	GO:0044089	80	0.028
ribonucleoside catabolic process	GO:0042454	112	0.028
single organism intracellular transport	GO:1902582	207	0.028
imaginal disc derived appendage development	GO:0048737	399	0.028
female meiotic division	GO:0007143	70	0.028
organophosphate catabolic process	GO:0046434	112	0.028
cytoplasmic transport	GO:0016482	130	0.028
negative regulation of cell cycle	GO:0045786	116	0.028
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.028
nucleoside catabolic process	GO:0009164	112	0.027
positive regulation of developmental process	GO:0051094	143	0.027
purine ribonucleotide catabolic process	GO:0009154	109	0.027
retrograde axon cargo transport	GO:0008090	9	0.027
regulation of cellular component biogenesis	GO:0044087	201	0.027
actin cytoskeleton reorganization	GO:0031532	22	0.027
head development	GO:0060322	135	0.027
digestive system development	GO:0055123	149	0.027
regulation of catalytic activity	GO:0050790	185	0.027
single organism cellular localization	GO:1902580	180	0.027
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.026
purine nucleoside catabolic process	GO:0006152	112	0.026
negative regulation of intracellular signal transduction	GO:1902532	57	0.026
regulation of protein modification process	GO:0031399	112	0.026
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.026
homeostatic process	GO:0042592	199	0.026	Fly
ribose phosphate metabolic process	GO:0019693	145	0.026
positive regulation of cell communication	GO:0010647	250	0.026
cell projection assembly	GO:0030031	94	0.026	Fly
regulation of multi organism process	GO:0043900	131	0.026
developmental growth	GO:0048589	280	0.026	Rat Fly
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.026
defense response to bacterium	GO:0042742	178	0.025
pronuclear migration	GO:0035046	4	0.025
camera type eye development	GO:0043010	4	0.025
purine nucleotide catabolic process	GO:0006195	109	0.025
carbohydrate derivative metabolic process	GO:1901135	217	0.025
regulation of cell projection organization	GO:0031344	92	0.025
generation of precursor metabolites and energy	GO:0006091	42	0.025
regulation of purine nucleotide catabolic process	GO:0033121	48	0.024
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.024
post embryonic appendage morphogenesis	GO:0035120	385	0.024
regulation of cellular amine metabolic process	GO:0033238	3	0.024
chaeta development	GO:0022416	97	0.024
defense response	GO:0006952	300	0.024	Worm Fly
muscle organ development	GO:0007517	127	0.024
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.024
cellular ketone metabolic process	GO:0042180	24	0.024
regulation of actin cytoskeleton organization	GO:0032956	42	0.023
response to nutrient levels	GO:0031667	114	0.023
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.023
positive regulation of rna biosynthetic process	GO:1902680	266	0.023	Fly
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.023
actin cytoskeleton organization	GO:0030036	206	0.023	Fly
r7 cell differentiation	GO:0045466	43	0.022
translation	GO:0006412	69	0.022
establishment or maintenance of cell polarity	GO:0007163	167	0.022
regulation of wnt signaling pathway	GO:0030111	68	0.022
intracellular signal transduction	GO:0035556	300	0.022
positive regulation of nervous system development	GO:0051962	69	0.022
regulation of dendrite development	GO:0050773	37	0.022
positive regulation of gene expression	GO:0010628	290	0.022	Fly
positive regulation of cellular catabolic process	GO:0031331	95	0.022	Fly
organic hydroxy compound metabolic process	GO:1901615	83	0.022	Fly
forebrain development	GO:0030900	2	0.022
ribonucleotide catabolic process	GO:0009261	109	0.022
regulation of anatomical structure size	GO:0090066	163	0.022
asymmetric protein localization	GO:0008105	33	0.022
nitrogen compound transport	GO:0071705	85	0.022
regulation of phosphorylation	GO:0042325	147	0.022
negative regulation of cellular component organization	GO:0051129	108	0.022
establishment of organelle localization	GO:0051656	122	0.021
cellular response to endogenous stimulus	GO:0071495	80	0.021
adult locomotory behavior	GO:0008344	76	0.021
regulation of transport	GO:0051049	181	0.021
regulation of protein metabolic process	GO:0051246	256	0.021
central nervous system development	GO:0007417	201	0.021
wing disc pattern formation	GO:0035222	66	0.021
regulation of response to biotic stimulus	GO:0002831	63	0.021
gtp catabolic process	GO:0006184	72	0.021
imaginal disc pattern formation	GO:0007447	91	0.021
positive regulation of signaling	GO:0023056	243	0.020
cellular amino acid metabolic process	GO:0006520	61	0.020
regulation of nucleotide metabolic process	GO:0006140	62	0.020
regulation of cytoskeleton organization	GO:0051493	89	0.020
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.020
regulation of cell shape	GO:0008360	113	0.020
cellular response to chemical stimulus	GO:0070887	199	0.020	Rat Fly
protein phosphorylation	GO:0006468	169	0.020
cytokinesis	GO:0000910	90	0.020
cellular lipid metabolic process	GO:0044255	83	0.020
regulation of cellular component size	GO:0032535	98	0.020
hindgut development	GO:0061525	58	0.020
synapse organization	GO:0050808	196	0.020	Worm
regulation of ras gtpase activity	GO:0032318	38	0.020
spermatid differentiation	GO:0048515	114	0.020
multi organism reproductive behavior	GO:0044705	121	0.020
nucleotide metabolic process	GO:0009117	161	0.020
positive regulation of intracellular signal transduction	GO:1902533	116	0.020
chromatin organization	GO:0006325	207	0.019
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.019
bmp signaling pathway	GO:0030509	27	0.019
nucleoside triphosphate catabolic process	GO:0009143	108	0.019
regulation of catabolic process	GO:0009894	170	0.019	Fly
cellular response to organic substance	GO:0071310	132	0.019	Rat
nucleoside metabolic process	GO:0009116	127	0.019
chromosome segregation	GO:0007059	157	0.019
positive regulation of cell development	GO:0010720	61	0.019
small molecule metabolic process	GO:0044281	305	0.019
regulation of meiosis	GO:0040020	3	0.019
digestive tract morphogenesis	GO:0048546	127	0.018
reproductive behavior	GO:0019098	122	0.018
ion transmembrane transport	GO:0034220	122	0.018
positive regulation of molecular function	GO:0044093	136	0.018
imaginal disc derived leg morphogenesis	GO:0007480	80	0.018
regulation of immune system process	GO:0002682	176	0.018	Fly
signal transduction by phosphorylation	GO:0023014	107	0.018
purine ribonucleotide metabolic process	GO:0009150	145	0.018
axon midline choice point recognition	GO:0016199	26	0.018
positive regulation of cellular amine metabolic process	GO:0033240	0	0.017
ovarian fusome organization	GO:0030723	11	0.017
posttranscriptional regulation of gene expression	GO:0010608	145	0.017	Worm
protein modification by small protein conjugation or removal	GO:0070647	106	0.017
regulation of bmp signaling pathway	GO:0030510	23	0.017
regulation of protein kinase activity	GO:0045859	51	0.017
purine ribonucleoside metabolic process	GO:0046128	127	0.017
positive regulation of cellular protein metabolic process	GO:0032270	118	0.017
ion transport	GO:0006811	145	0.017
positive regulation of response to external stimulus	GO:0032103	44	0.017
regulation of membrane potential	GO:0042391	35	0.017
positive regulation of growth	GO:0045927	75	0.017
axis specification	GO:0009798	167	0.017
signal transduction in response to dna damage	GO:0042770	3	0.016
response to transforming growth factor beta	GO:0071559	18	0.016
lateral inhibition	GO:0046331	206	0.016
response to growth factor	GO:0070848	31	0.016
positive regulation of phosphorylation	GO:0042327	87	0.016
regulation of protein polymerization	GO:0032271	28	0.016
regulation of nucleotide catabolic process	GO:0030811	48	0.016
purine ribonucleoside catabolic process	GO:0046130	112	0.016
regulation of cellular ketone metabolic process	GO:0010565	3	0.016
glycosyl compound metabolic process	GO:1901657	127	0.016
proteolysis	GO:0006508	192	0.016
detection of stimulus	GO:0051606	156	0.016
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.016
protein targeting	GO:0006605	64	0.016
retinal ganglion cell axon guidance	GO:0031290	12	0.016
regulation of cellular catabolic process	GO:0031329	157	0.015	Fly
localization of cell	GO:0051674	257	0.015	Fly
positive regulation of cell motility	GO:2000147	3	0.015
salivary gland development	GO:0007431	162	0.015
somatic muscle development	GO:0007525	66	0.015
exocrine system development	GO:0035272	162	0.015
negative regulation of organelle organization	GO:0010639	56	0.015
brain morphogenesis	GO:0048854	16	0.015
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.015
positive regulation of immune response	GO:0050778	63	0.015
aging	GO:0007568	143	0.015	Fly
protein polymerization	GO:0051258	42	0.015
glycerophospholipid metabolic process	GO:0006650	23	0.015
developmental programmed cell death	GO:0010623	138	0.015
immune response	GO:0006955	246	0.015	Fly
regulation of photoreceptor cell differentiation	GO:0046532	34	0.015
response to abiotic stimulus	GO:0009628	341	0.015	Human Fly
axon choice point recognition	GO:0016198	26	0.015
positive regulation of transcription dna templated	GO:0045893	266	0.015	Fly
pigmentation	GO:0043473	75	0.014
phagocytosis	GO:0006909	215	0.014	Fly
response to alcohol	GO:0097305	95	0.014
regulation of cellular response to stress	GO:0080135	89	0.014
dorsal ventral axon guidance	GO:0033563	2	0.014
body morphogenesis	GO:0010171	2	0.014
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.014
apoptotic process	GO:0006915	159	0.014	Rat
nucleobase containing compound catabolic process	GO:0034655	165	0.014
positive regulation of protein complex assembly	GO:0031334	22	0.014
small molecule biosynthetic process	GO:0044283	37	0.014
cell migration	GO:0016477	238	0.014	Fly
heterocycle catabolic process	GO:0046700	166	0.014
innate immune response	GO:0045087	144	0.014	Fly
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.014
regulation of anatomical structure morphogenesis	GO:0022603	242	0.014
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.014
regulation of stem cell proliferation	GO:0072091	40	0.014
organonitrogen compound biosynthetic process	GO:1901566	117	0.014
organic acid metabolic process	GO:0006082	103	0.013
mitotic cell cycle embryonic	GO:0045448	38	0.013
phosphatidylcholine metabolic process	GO:0046470	3	0.013
limb development	GO:0060173	1	0.013
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.013
positive regulation of neurogenesis	GO:0050769	41	0.013
positive regulation of catabolic process	GO:0009896	105	0.013	Fly
protein transport	GO:0015031	155	0.013
cell fate specification	GO:0001708	71	0.013
adult behavior	GO:0030534	137	0.013
actin polymerization or depolymerization	GO:0008154	31	0.013
female meiosis chromosome segregation	GO:0016321	33	0.013
centrosome separation	GO:0051299	20	0.013
cytoskeleton dependent cytokinesis	GO:0061640	81	0.013
cellular response to growth factor stimulus	GO:0071363	30	0.013
regulation of multicellular organismal development	GO:2000026	414	0.013
somatic stem cell maintenance	GO:0035019	14	0.013
oocyte axis specification	GO:0007309	108	0.013
cell cycle phase transition	GO:0044770	140	0.013
single fertilization	GO:0007338	24	0.013
instar larval development	GO:0002168	55	0.013
regulation of gliogenesis	GO:0014013	11	0.013
organonitrogen compound catabolic process	GO:1901565	128	0.013
anterior posterior axis specification embryo	GO:0008595	103	0.013
regulation of epithelial cell proliferation	GO:0050678	4	0.013
regulation of purine nucleotide metabolic process	GO:1900542	62	0.013
germarium derived egg chamber formation	GO:0007293	101	0.013
embryonic morphogenesis	GO:0048598	206	0.012	Fly
macromolecule catabolic process	GO:0009057	161	0.012
negative regulation of cellular metabolic process	GO:0031324	382	0.012
camera type eye morphogenesis	GO:0048593	2	0.012
positive regulation of dendrite morphogenesis	GO:0050775	9	0.012
death	GO:0016265	284	0.012	Rat
peptidyl amino acid modification	GO:0018193	105	0.012
wing disc morphogenesis	GO:0007472	344	0.012
cell division	GO:0051301	248	0.012
protein catabolic process	GO:0030163	101	0.012
regulation of response to external stimulus	GO:0032101	115	0.012
kidney development	GO:0001822	3	0.012
positive regulation of cell projection organization	GO:0031346	29	0.012
reciprocal dna recombination	GO:0035825	19	0.012
purine containing compound metabolic process	GO:0072521	155	0.012
negative regulation of cell proliferation	GO:0008285	69	0.011
negative regulation of cell communication	GO:0010648	223	0.011
regulation of gtp catabolic process	GO:0033124	44	0.011
regulation of microtubule based process	GO:0032886	49	0.011
histone modification	GO:0016570	106	0.011
glycerolipid metabolic process	GO:0046486	34	0.011
cognition	GO:0050890	141	0.011
startle response	GO:0001964	16	0.011
positive regulation of cell differentiation	GO:0045597	64	0.011
regulation of cellular protein metabolic process	GO:0032268	243	0.011
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.011
epithelial cell development	GO:0002064	274	0.011	Fly
chromosome organization	GO:0051276	360	0.011
lipid metabolic process	GO:0006629	121	0.011
regulation of cellular localization	GO:0060341	136	0.011
spinal cord development	GO:0021510	1	0.011
learning or memory	GO:0007611	141	0.011
morphogenesis of embryonic epithelium	GO:0016331	94	0.011	Fly
positive regulation of organelle organization	GO:0010638	65	0.011
erk1 and erk2 cascade	GO:0070371	39	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.011
mitotic cell cycle phase transition	GO:0044772	138	0.011
larval behavior	GO:0030537	42	0.011
cytoskeleton dependent intracellular transport	GO:0030705	44	0.011
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.011
mesenchymal cell development	GO:0014031	1	0.011
positive regulation of ras protein signal transduction	GO:0046579	43	0.010
nucleocytoplasmic transport	GO:0006913	72	0.010
microtubule based movement	GO:0007018	51	0.010
regulation of developmental pigmentation	GO:0048070	24	0.010
response to other organism	GO:0051707	293	0.010
membrane budding	GO:0006900	4	0.010
positive regulation of nucleotide metabolic process	GO:0045981	55	0.010
retina development in camera type eye	GO:0060041	4	0.010
nuclear export	GO:0051168	24	0.010
hematopoietic progenitor cell differentiation	GO:0002244	1	0.010
leg disc morphogenesis	GO:0007478	80	0.010
positive regulation of cell migration	GO:0030335	2	0.010
positive regulation of programmed cell death	GO:0043068	62	0.010	Rat

Mkk4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.037
nervous system disease	DOID:863	0.033
central nervous system disease	DOID:331	0.033
motor neuron disease	DOID:231	0.012
neurodegenerative disease	DOID:1289	0.012

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