Drosophila melanogaster

142 known processes

Mkk4 (Dmel_CG9738)

MAP kinase kinase 4

(Aliases: 142758_at,mkk4,DMKK4,CT27508,Dmel\CG9738,MKK4,dMKK4,CG9738,JNKK2,Mpk4,SEK1/MKK4,D-MKK4)

Mkk4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
axonogenesisGO:00074092900.621
Fly
axon guidanceGO:00074112330.450
synaptic transmissionGO:00072682880.442
Worm
negative regulation of rna metabolic processGO:00512532510.425
eye developmentGO:00016543230.358
meiotic cell cycleGO:00513211710.352
taxisGO:00423303040.324
axon developmentGO:00615642970.318
Fly
compound eye morphogenesisGO:00017452490.305
negative regulation of transcription dna templatedGO:00458922370.296
sensory organ morphogenesisGO:00905962600.264
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.258
dendrite developmentGO:00163582040.254
negative regulation of macromolecule biosynthetic processGO:00105582700.201
spindle organizationGO:00070512530.196
regulation of nervous system developmentGO:00519602480.191
chemotaxisGO:00069352490.177
multi organism behaviorGO:00517051750.169
muscle structure developmentGO:00610612240.164
Rat
dendrite morphogenesisGO:00488131990.156
negative regulation of rna biosynthetic processGO:19026792400.145
neurological system processGO:00508773580.145
compound eye photoreceptor developmentGO:0042051780.144
regulation of neurogenesisGO:00507671580.142
neuron projection guidanceGO:00974852410.140
regulation of cell developmentGO:00602842150.137
positive regulation of multicellular organismal processGO:00512401430.135
ras protein signal transductionGO:0007265880.134
response to organic substanceGO:00100332840.129
Rat
compound eye developmentGO:00487493070.129
regionalizationGO:00030024160.128
Zebrafish Fly
mitotic spindle organizationGO:00070522200.121
positive regulation of biosynthetic processGO:00098913160.118
Rat Fly
regulation of cell differentiationGO:00455953020.117
Fly
stem cell differentiationGO:00488631170.113
organelle assemblyGO:00709251980.112
transcription from rna polymerase ii promoterGO:00063663680.109
organelle fissionGO:00482853400.105
cellular protein modification processGO:00064644380.103
ribonucleotide metabolic processGO:00092591450.101
photoreceptor cell differentiationGO:00465301700.098
regulation of ras protein signal transductionGO:0046578930.098
organelle localizationGO:00516401480.097
regulation of intracellular signal transductionGO:19025312360.094
actin filament organizationGO:00070151260.092
Fly
male gamete generationGO:00482322010.091
regulation of cell cycleGO:00517262910.090
fertilizationGO:0009566260.089
regulation of neuron differentiationGO:00456641030.088
endomembrane system organizationGO:00102561190.088
organonitrogen compound metabolic processGO:19015643180.086
small gtpase mediated signal transductionGO:0007264880.086
meiotic nuclear divisionGO:00071261510.086
segmentationGO:00352822070.084
stem cell proliferationGO:0072089880.082
ethanolamine containing compound metabolic processGO:004243940.078
macromolecular complex assemblyGO:00650032560.078
positive regulation of cellular biosynthetic processGO:00313283160.076
Rat Fly
nuclear divisionGO:00002803320.074
negative regulation of nucleobase containing compound metabolic processGO:00459342610.072
negative regulation of nucleic acid templated transcriptionGO:19035072400.072
membrane organizationGO:00610241120.071
Fly
amine metabolic processGO:0009308120.071
eye morphogenesisGO:00485922600.071
neuron recognitionGO:00080381010.071
determination of adult lifespanGO:00083401370.071
Fly
negative regulation of cellular biosynthetic processGO:00313272770.070
positive regulation of macromolecule biosynthetic processGO:00105572830.069
Rat Fly
negative regulation of cell cycle processGO:00109481090.068
eye photoreceptor cell differentiationGO:00017541450.067
mitotic nuclear divisionGO:00070672130.065
organophosphate metabolic processGO:00196371950.063
organic substance catabolic processGO:19015753080.062
dorsal ventral pattern formationGO:00099531330.061
Zebrafish
protein complex biogenesisGO:00702712010.060
ribonucleoside triphosphate metabolic processGO:00091991190.060
compound eye photoreceptor cell differentiationGO:00017511400.059
protein complex assemblyGO:00064612000.059
regulation of organelle organizationGO:00330431960.059
cellular macromolecule localizationGO:00707272200.058
regulation of transcription from rna polymerase ii promoterGO:00063573780.058
protein modification processGO:00362114380.058
regulation of neuron projection developmentGO:0010975690.058
single organism membrane organizationGO:0044802930.057
photoreceptor cell developmentGO:0042461960.056
ribonucleoside metabolic processGO:00091191270.055
meiotic cell cycle processGO:19030461320.054
eye photoreceptor cell developmentGO:0042462810.054
purine ribonucleoside triphosphate catabolic processGO:00092071080.053
glycosyl compound catabolic processGO:19016581120.052
vesicle mediated transportGO:00161923810.051
Fly
positive regulation of phosphorus metabolic processGO:00105621390.051
negative regulation of nitrogen compound metabolic processGO:00511722650.050
positive regulation of nucleic acid templated transcriptionGO:19035082660.050
Fly
regulation of small gtpase mediated signal transductionGO:0051056930.049
oocyte differentiationGO:00099941450.049
regulation of phosphorus metabolic processGO:00511742100.049
positive regulation of macromolecule metabolic processGO:00106044050.049
cell recognitionGO:00080371020.049
regulation of cell cycle processGO:00105641810.049
cellular catabolic processGO:00442483720.049
Fly
growthGO:00400073590.048
Rat Fly
brain developmentGO:00074201200.048
aromatic compound catabolic processGO:00194391660.048
synapse assemblyGO:00074161430.048
guanosine containing compound metabolic processGO:1901068740.048
guanosine containing compound catabolic processGO:1901069740.047
endocytosisGO:00068973100.046
Fly
nucleoside phosphate catabolic processGO:19012921100.045
phosphorylationGO:00163102940.045
hindgut morphogenesisGO:0007442580.044
positive regulation of protein metabolic processGO:00512471280.044
negative regulation of cell developmentGO:0010721620.044
embryonic pattern specificationGO:00098801740.044
regulation of molecular functionGO:00650092170.044
cation transportGO:00068121100.043
dna metabolic processGO:00062592270.042
Rat
single organism behaviorGO:00447083910.042
intracellular transportGO:00469072280.042
negative regulation of cell cycle phase transitionGO:19019881030.042
spermatogenesisGO:00072832000.041
negative regulation of biosynthetic processGO:00098902770.041
regulation of phosphate metabolic processGO:00192202100.041
blastoderm segmentationGO:00073501590.040
cellular response to transforming growth factor beta stimulusGO:0071560180.040
locomotory behaviorGO:00076261760.040
meiotic chromosome segregationGO:0045132590.040
cell fate determinationGO:0001709910.040
negative regulation of neurogenesisGO:0050768530.040
positive regulation of rna metabolic processGO:00512542710.040
Fly
positive regulation of cellular component organizationGO:00511301560.039
negative regulation of cell differentiationGO:00455961430.039
synaptic growth at neuromuscular junctionGO:00511241190.039
cell deathGO:00082192790.038
Rat
appendage developmentGO:00487364010.038
protein localizationGO:00081042840.038
catabolic processGO:00090564090.038
Fly
cellular amine metabolic processGO:0044106120.038
organic cyclic compound catabolic processGO:19013611680.037
spindle elongationGO:0051231830.037
establishment of localization in cellGO:00516494020.037
purine nucleoside triphosphate catabolic processGO:00091461080.037
regulation of response to stressGO:00801342000.037
positive regulation of phosphate metabolic processGO:00459371390.037
leg disc developmentGO:0035218920.036
negative regulation of gene expressionGO:00106293870.036
Worm
regulation of mitotic cell cycleGO:00073461900.036
gland developmentGO:00487321910.036
regulation of protein complex assemblyGO:0043254420.036
lipid biosynthetic processGO:0008610460.036
positive regulation of nucleobase containing compound metabolic processGO:00459353320.035
Rat Fly
regulation of cell morphogenesisGO:00226041630.035
mapk cascadeGO:00001651070.035
purine containing compound catabolic processGO:00725231120.035
sensory perceptionGO:00076001960.035
regulation of synapse structure and activityGO:00508031280.034
Worm
purine nucleotide metabolic processGO:00061631460.034
response to external biotic stimulusGO:00432072930.034
negative regulation of nervous system developmentGO:0051961920.033
regulation of cell deathGO:00109411730.033
Rat
stem cell developmentGO:0048864790.033
single organism catabolic processGO:00447122280.033
negative regulation of developmental processGO:00510932010.032
telencephalon developmentGO:002153720.032
mitochondrion organizationGO:0007005650.032
cellular protein localizationGO:00346131600.032
intracellular protein transportGO:00068861040.032
embryonic development via the syncytial blastodermGO:00017001480.032
Fly
regulation of localizationGO:00328792750.032
embryo development ending in birth or egg hatchingGO:00097921520.032
Fly
stem cell maintenanceGO:0019827670.032
positive regulation of response to stimulusGO:00485843230.032
meiosis iGO:0007127590.031
carbohydrate derivative catabolic processGO:19011361180.031
dendrite guidanceGO:0070983210.031
nucleoside triphosphate metabolic processGO:00091411200.031
cellular protein complex assemblyGO:0043623710.031
regulation of synaptic transmissionGO:0050804690.031
chromatin silencingGO:0006342760.031
gtp metabolic processGO:0046039720.031
anterior posterior pattern specificationGO:00099521360.031
single organism biosynthetic processGO:00447112060.031
regulation of actin filament lengthGO:0030832270.031
regulation of cell cycle phase transitionGO:19019871300.030
immune system processGO:00023763470.030
Fly
response to bacteriumGO:00096171980.030
protein modification by small protein conjugationGO:0032446790.030
cell growthGO:00160491080.029
Rat Fly
spermatid developmentGO:0007286980.029
cellular macromolecular complex assemblyGO:00346221530.029
cellular response to dna damage stimulusGO:00069742230.029
nucleobase containing small molecule metabolic processGO:00550861740.029
defense response to other organismGO:00985422250.029
protein ubiquitinationGO:0016567700.029
regulation of dendrite morphogenesisGO:0048814280.029
nucleotide catabolic processGO:00091661090.028
positive regulation of cellular component biogenesisGO:0044089800.028
ribonucleoside catabolic processGO:00424541120.028
single organism intracellular transportGO:19025822070.028
imaginal disc derived appendage developmentGO:00487373990.028
female meiotic divisionGO:0007143700.028
organophosphate catabolic processGO:00464341120.028
cytoplasmic transportGO:00164821300.028
negative regulation of cell cycleGO:00457861160.028
positive regulation of cellular amino acid metabolic processGO:004576400.028
nucleoside catabolic processGO:00091641120.027
positive regulation of developmental processGO:00510941430.027
purine ribonucleotide catabolic processGO:00091541090.027
retrograde axon cargo transportGO:000809090.027
regulation of cellular component biogenesisGO:00440872010.027
actin cytoskeleton reorganizationGO:0031532220.027
head developmentGO:00603221350.027
digestive system developmentGO:00551231490.027
regulation of catalytic activityGO:00507901850.027
single organism cellular localizationGO:19025801800.027
purine ribonucleoside triphosphate metabolic processGO:00092051190.026
purine nucleoside catabolic processGO:00061521120.026
negative regulation of intracellular signal transductionGO:1902532570.026
regulation of protein modification processGO:00313991120.026
purine nucleoside triphosphate metabolic processGO:00091441190.026
homeostatic processGO:00425921990.026
Fly
ribose phosphate metabolic processGO:00196931450.026
positive regulation of cell communicationGO:00106472500.026
cell projection assemblyGO:0030031940.026
Fly
regulation of multi organism processGO:00439001310.026
developmental growthGO:00485892800.026
Rat Fly
transforming growth factor beta receptor signaling pathwayGO:0007179160.026
defense response to bacteriumGO:00427421780.025
pronuclear migrationGO:003504640.025
camera type eye developmentGO:004301040.025
purine nucleotide catabolic processGO:00061951090.025
carbohydrate derivative metabolic processGO:19011352170.025
regulation of cell projection organizationGO:0031344920.025
generation of precursor metabolites and energyGO:0006091420.025
regulation of purine nucleotide catabolic processGO:0033121480.024
maternal determination of anterior posterior axis embryoGO:0008358740.024
post embryonic appendage morphogenesisGO:00351203850.024
regulation of cellular amine metabolic processGO:003323830.024
chaeta developmentGO:0022416970.024
defense responseGO:00069523000.024
Worm Fly
muscle organ developmentGO:00075171270.024
enzyme linked receptor protein signaling pathwayGO:00071671790.024
cellular ketone metabolic processGO:0042180240.024
regulation of actin cytoskeleton organizationGO:0032956420.023
response to nutrient levelsGO:00316671140.023
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092380.023
positive regulation of rna biosynthetic processGO:19026802660.023
Fly
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.023
actin cytoskeleton organizationGO:00300362060.023
Fly
r7 cell differentiationGO:0045466430.022
translationGO:0006412690.022
establishment or maintenance of cell polarityGO:00071631670.022
regulation of wnt signaling pathwayGO:0030111680.022
intracellular signal transductionGO:00355563000.022
positive regulation of nervous system developmentGO:0051962690.022
regulation of dendrite developmentGO:0050773370.022
positive regulation of gene expressionGO:00106282900.022
Fly
positive regulation of cellular catabolic processGO:0031331950.022
Fly
organic hydroxy compound metabolic processGO:1901615830.022
Fly
forebrain developmentGO:003090020.022
ribonucleotide catabolic processGO:00092611090.022
regulation of anatomical structure sizeGO:00900661630.022
asymmetric protein localizationGO:0008105330.022
nitrogen compound transportGO:0071705850.022
regulation of phosphorylationGO:00423251470.022
negative regulation of cellular component organizationGO:00511291080.022
establishment of organelle localizationGO:00516561220.021
cellular response to endogenous stimulusGO:0071495800.021
adult locomotory behaviorGO:0008344760.021
regulation of transportGO:00510491810.021
regulation of protein metabolic processGO:00512462560.021
central nervous system developmentGO:00074172010.021
wing disc pattern formationGO:0035222660.021
regulation of response to biotic stimulusGO:0002831630.021
gtp catabolic processGO:0006184720.021
imaginal disc pattern formationGO:0007447910.021
positive regulation of signalingGO:00230562430.020
cellular amino acid metabolic processGO:0006520610.020
regulation of nucleotide metabolic processGO:0006140620.020
regulation of cytoskeleton organizationGO:0051493890.020
ribonucleoside triphosphate catabolic processGO:00092031080.020
regulation of cell shapeGO:00083601130.020
cellular response to chemical stimulusGO:00708871990.020
Rat Fly
protein phosphorylationGO:00064681690.020
cytokinesisGO:0000910900.020
cellular lipid metabolic processGO:0044255830.020
regulation of cellular component sizeGO:0032535980.020
hindgut developmentGO:0061525580.020
synapse organizationGO:00508081960.020
Worm
regulation of ras gtpase activityGO:0032318380.020
spermatid differentiationGO:00485151140.020
multi organism reproductive behaviorGO:00447051210.020
nucleotide metabolic processGO:00091171610.020
positive regulation of intracellular signal transductionGO:19025331160.020
chromatin organizationGO:00063252070.019
positive regulation of erk1 and erk2 cascadeGO:0070374360.019
bmp signaling pathwayGO:0030509270.019
nucleoside triphosphate catabolic processGO:00091431080.019
regulation of catabolic processGO:00098941700.019
Fly
cellular response to organic substanceGO:00713101320.019
Rat
nucleoside metabolic processGO:00091161270.019
chromosome segregationGO:00070591570.019
positive regulation of cell developmentGO:0010720610.019
small molecule metabolic processGO:00442813050.019
regulation of meiosisGO:004002030.019
digestive tract morphogenesisGO:00485461270.018
reproductive behaviorGO:00190981220.018
ion transmembrane transportGO:00342201220.018
positive regulation of molecular functionGO:00440931360.018
imaginal disc derived leg morphogenesisGO:0007480800.018
regulation of immune system processGO:00026821760.018
Fly
signal transduction by phosphorylationGO:00230141070.018
purine ribonucleotide metabolic processGO:00091501450.018
axon midline choice point recognitionGO:0016199260.018
positive regulation of cellular amine metabolic processGO:003324000.017
ovarian fusome organizationGO:0030723110.017
posttranscriptional regulation of gene expressionGO:00106081450.017
Worm
protein modification by small protein conjugation or removalGO:00706471060.017
regulation of bmp signaling pathwayGO:0030510230.017
regulation of protein kinase activityGO:0045859510.017
purine ribonucleoside metabolic processGO:00461281270.017
positive regulation of cellular protein metabolic processGO:00322701180.017
ion transportGO:00068111450.017
positive regulation of response to external stimulusGO:0032103440.017
regulation of membrane potentialGO:0042391350.017
positive regulation of growthGO:0045927750.017
axis specificationGO:00097981670.017
signal transduction in response to dna damageGO:004277030.016
response to transforming growth factor betaGO:0071559180.016
lateral inhibitionGO:00463312060.016
response to growth factorGO:0070848310.016
positive regulation of phosphorylationGO:0042327870.016
regulation of protein polymerizationGO:0032271280.016
regulation of nucleotide catabolic processGO:0030811480.016
purine ribonucleoside catabolic processGO:00461301120.016
regulation of cellular ketone metabolic processGO:001056530.016
glycosyl compound metabolic processGO:19016571270.016
proteolysisGO:00065081920.016
detection of stimulusGO:00516061560.016
regulation of mitotic cell cycle phase transitionGO:19019901300.016
protein targetingGO:0006605640.016
retinal ganglion cell axon guidanceGO:0031290120.016
regulation of cellular catabolic processGO:00313291570.015
Fly
localization of cellGO:00516742570.015
Fly
positive regulation of cell motilityGO:200014730.015
salivary gland developmentGO:00074311620.015
somatic muscle developmentGO:0007525660.015
exocrine system developmentGO:00352721620.015
negative regulation of organelle organizationGO:0010639560.015
brain morphogenesisGO:0048854160.015
regulation of microtubule cytoskeleton organizationGO:0070507410.015
positive regulation of immune responseGO:0050778630.015
agingGO:00075681430.015
Fly
protein polymerizationGO:0051258420.015
glycerophospholipid metabolic processGO:0006650230.015
developmental programmed cell deathGO:00106231380.015
immune responseGO:00069552460.015
Fly
regulation of photoreceptor cell differentiationGO:0046532340.015
response to abiotic stimulusGO:00096283410.015
Human Fly
axon choice point recognitionGO:0016198260.015
positive regulation of transcription dna templatedGO:00458932660.015
Fly
pigmentationGO:0043473750.014
phagocytosisGO:00069092150.014
Fly
response to alcoholGO:0097305950.014
regulation of cellular response to stressGO:0080135890.014
dorsal ventral axon guidanceGO:003356320.014
body morphogenesisGO:001017120.014
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.014
apoptotic processGO:00069151590.014
Rat
nucleobase containing compound catabolic processGO:00346551650.014
positive regulation of protein complex assemblyGO:0031334220.014
small molecule biosynthetic processGO:0044283370.014
cell migrationGO:00164772380.014
Fly
heterocycle catabolic processGO:00467001660.014
innate immune responseGO:00450871440.014
Fly
cell cell signaling involved in cell fate commitmentGO:00451682100.014
regulation of anatomical structure morphogenesisGO:00226032420.014
negative regulation of sequence specific dna binding transcription factor activityGO:004343340.014
regulation of stem cell proliferationGO:0072091400.014
organonitrogen compound biosynthetic processGO:19015661170.014
organic acid metabolic processGO:00060821030.013
mitotic cell cycle embryonicGO:0045448380.013
phosphatidylcholine metabolic processGO:004647030.013
limb developmentGO:006017310.013
imaginal disc derived appendage morphogenesisGO:00351143950.013
positive regulation of neurogenesisGO:0050769410.013
positive regulation of catabolic processGO:00098961050.013
Fly
protein transportGO:00150311550.013
cell fate specificationGO:0001708710.013
adult behaviorGO:00305341370.013
actin polymerization or depolymerizationGO:0008154310.013
female meiosis chromosome segregationGO:0016321330.013
centrosome separationGO:0051299200.013
cytoskeleton dependent cytokinesisGO:0061640810.013
cellular response to growth factor stimulusGO:0071363300.013
regulation of multicellular organismal developmentGO:20000264140.013
somatic stem cell maintenanceGO:0035019140.013
oocyte axis specificationGO:00073091080.013
cell cycle phase transitionGO:00447701400.013
single fertilizationGO:0007338240.013
instar larval developmentGO:0002168550.013
regulation of gliogenesisGO:0014013110.013
organonitrogen compound catabolic processGO:19015651280.013
anterior posterior axis specification embryoGO:00085951030.013
regulation of epithelial cell proliferationGO:005067840.013
regulation of purine nucleotide metabolic processGO:1900542620.013
germarium derived egg chamber formationGO:00072931010.013
embryonic morphogenesisGO:00485982060.012
Fly
macromolecule catabolic processGO:00090571610.012
negative regulation of cellular metabolic processGO:00313243820.012
camera type eye morphogenesisGO:004859320.012
positive regulation of dendrite morphogenesisGO:005077590.012
deathGO:00162652840.012
Rat
peptidyl amino acid modificationGO:00181931050.012
wing disc morphogenesisGO:00074723440.012
cell divisionGO:00513012480.012
protein catabolic processGO:00301631010.012
regulation of response to external stimulusGO:00321011150.012
kidney developmentGO:000182230.012
positive regulation of cell projection organizationGO:0031346290.012
reciprocal dna recombinationGO:0035825190.012
purine containing compound metabolic processGO:00725211550.012
negative regulation of cell proliferationGO:0008285690.011
negative regulation of cell communicationGO:00106482230.011
regulation of gtp catabolic processGO:0033124440.011
regulation of microtubule based processGO:0032886490.011
histone modificationGO:00165701060.011
glycerolipid metabolic processGO:0046486340.011
cognitionGO:00508901410.011
startle responseGO:0001964160.011
positive regulation of cell differentiationGO:0045597640.011
regulation of cellular protein metabolic processGO:00322682430.011
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.011
epithelial cell developmentGO:00020642740.011
Fly
chromosome organizationGO:00512763600.011
lipid metabolic processGO:00066291210.011
regulation of cellular localizationGO:00603411360.011
spinal cord developmentGO:002151010.011
learning or memoryGO:00076111410.011
morphogenesis of embryonic epitheliumGO:0016331940.011
Fly
positive regulation of organelle organizationGO:0010638650.011
erk1 and erk2 cascadeGO:0070371390.011
regulation of cellular amino acid metabolic processGO:000652100.011
mitotic cell cycle phase transitionGO:00447721380.011
larval behaviorGO:0030537420.011
cytoskeleton dependent intracellular transportGO:0030705440.011
regulation of cell morphogenesis involved in differentiationGO:0010769610.011
mesenchymal cell developmentGO:001403110.011
positive regulation of ras protein signal transductionGO:0046579430.010
nucleocytoplasmic transportGO:0006913720.010
microtubule based movementGO:0007018510.010
regulation of developmental pigmentationGO:0048070240.010
response to other organismGO:00517072930.010
membrane buddingGO:000690040.010
positive regulation of nucleotide metabolic processGO:0045981550.010
retina development in camera type eyeGO:006004140.010
nuclear exportGO:0051168240.010
hematopoietic progenitor cell differentiationGO:000224410.010
leg disc morphogenesisGO:0007478800.010
positive regulation of cell migrationGO:003033520.010
positive regulation of programmed cell deathGO:0043068620.010
Rat

Mkk4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.037
nervous system diseaseDOID:86300.033
central nervous system diseaseDOID:33100.033
motor neuron diseaseDOID:23100.012
neurodegenerative diseaseDOID:128900.012