Drosophila melanogaster

65 known processes

Spn4 (Dmel_CG9453)

Serine protease inhibitor 4

(Aliases: CG9453,Spn4A,Sp4,sp4,Spn42Da,Dmel\CG9453)

Spn4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
defense responseGO:00069523000.269
Rat Fly
negative regulation of signalingGO:00230572190.204
Fly
antifungal humoral responseGO:0019732120.171
Fly
peptide metabolic processGO:0006518800.160
immune system processGO:00023763470.153
Fly
toll signaling pathwayGO:0008063250.151
Fly
establishment of localization in cellGO:00516494020.150
negative regulation of response to stimulusGO:00485852580.122
Rat Fly
regulation of cell proliferationGO:00421271630.110
negative regulation of signal transductionGO:00099682060.108
Fly
immune responseGO:00069552460.098
Fly
regulation of localizationGO:00328792750.094
negative regulation of cell communicationGO:00106482230.094
Fly
wing disc morphogenesisGO:00074723440.090
regulation of multi organism processGO:00439001310.088
Fly
response to fungusGO:0009620500.087
Fly
regionalizationGO:00030024160.071
oxoacid metabolic processGO:00434361030.069
cellular amide metabolic processGO:0043603800.065
positive regulation of response to stimulusGO:00485843230.065
deathGO:00162652840.064
post embryonic appendage morphogenesisGO:00351203850.062
imaginal disc derived wing morphogenesisGO:00074763370.062
imaginal disc derived appendage developmentGO:00487373990.059
organic substance transportGO:00717022570.057
vesicle mediated transportGO:00161923810.056
negative regulation of gene expressionGO:00106293870.056
imaginal disc derived appendage morphogenesisGO:00351143950.055
response to other organismGO:00517072930.053
Fly
chaeta developmentGO:0022416970.049
regulation of notch signaling pathwayGO:00085931000.047
enzyme linked receptor protein signaling pathwayGO:00071671790.046
developmental growthGO:00485892800.045
Rat
proteolysisGO:00065081920.045
secretion by cellGO:00329401010.045
cell deathGO:00082192790.045
programmed cell deathGO:00125012570.043
response to bacteriumGO:00096171980.043
Fly
appendage developmentGO:00487364010.042
body morphogenesisGO:001017120.041
gland developmentGO:00487321910.040
response to abiotic stimulusGO:00096283410.038
immune response regulating signaling pathwayGO:000276420.036
intracellular transportGO:00469072280.035
appendage morphogenesisGO:00351073970.035
carbohydrate derivative biosynthetic processGO:1901137850.035
amino sugar metabolic processGO:0006040100.035
organonitrogen compound biosynthetic processGO:19015661170.035
positive regulation of biosynthetic processGO:00098913160.035
regulation of production of molecular mediator of immune responseGO:0002700440.034
Fly
immune response activating signal transductionGO:000275720.034
regulation of cellular localizationGO:00603411360.034
organic substance catabolic processGO:19015753080.033
response to external biotic stimulusGO:00432072930.033
Fly
secretionGO:00469031090.031
protein transportGO:00150311550.030
response to organic substanceGO:00100332840.030
regulation of defense response to bacteriumGO:1900424300.030
humoral immune responseGO:00069591170.030
Fly
protein modification processGO:00362114380.030
regulation of toll signaling pathwayGO:0008592170.029
Fly
growthGO:00400073590.029
Rat
agingGO:00075681430.029
cell proliferationGO:00082832990.028
cellular catabolic processGO:00442483720.028
positive regulation of cellular biosynthetic processGO:00313283160.028
developmental programmed cell deathGO:00106231380.028
positive regulation of transportGO:0051050920.028
regulation of intracellular signal transductionGO:19025312360.028
catabolic processGO:00090564090.028
positive regulation of cell communicationGO:00106472500.028
response to nutrient levelsGO:00316671140.028
Rat
positive regulation of signal transductionGO:00099672230.028
small molecule metabolic processGO:00442813050.027
positive regulation of nitrogen compound metabolic processGO:00511733540.027
regulation of multicellular organismal developmentGO:20000264140.026
defense response to gram positive bacteriumGO:0050830410.026
endocytosisGO:00068973100.026
cellular ketone metabolic processGO:0042180240.026
homeostatic processGO:00425921990.026
regulation of immune responseGO:00507761180.026
Fly
regulation of transcription from rna polymerase ii promoterGO:00063573780.025
cellular macromolecule localizationGO:00707272200.025
endomembrane system organizationGO:00102561190.025
axis specificationGO:00097981670.024
regulation of hormone levelsGO:0010817400.024
multi organism behaviorGO:00517051750.024
regulation of defense responseGO:00313471020.024
Rat
rna processingGO:00063961470.024
regulation of phosphorus metabolic processGO:00511742100.024
macromolecule catabolic processGO:00090571610.024
gland morphogenesisGO:00226121450.024
multicellular organismal agingGO:00102591400.023
single organism biosynthetic processGO:00447112060.023
extracellular matrix constituent secretionGO:007027840.023
open tracheal system developmentGO:00074242040.023
connective tissue developmentGO:006144830.022
regulation of response to stressGO:00801342000.022
Rat
regulation of programmed cell deathGO:00430671520.022
antimicrobial humoral responseGO:0019730990.022
Fly
response to light stimulusGO:00094161240.021
regulation of protein metabolic processGO:00512462560.020
regulation of secretionGO:0051046440.020
carbohydrate derivative metabolic processGO:19011352170.020
salivary gland morphogenesisGO:00074351450.020
maintenance of locationGO:0051235730.020
regulation of immune system processGO:00026821760.020
Fly
kidney developmentGO:000182230.020
negative regulation of cellular metabolic processGO:00313243820.020
positive regulation of signalingGO:00230562430.019
positive regulation of rna biosynthetic processGO:19026802660.019
notch signaling pathwayGO:00072191200.019
immune effector processGO:0002252980.019
Fly
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.019
spermatogenesisGO:00072832000.019
regulation of antimicrobial humoral responseGO:0002759500.019
Fly
phagocytosisGO:00069092150.019
epithelial cell differentiationGO:00308553220.019
regulation of cell cycleGO:00517262910.019
cellular protein modification processGO:00064644380.018
lipid metabolic processGO:00066291210.018
determination of adult lifespanGO:00083401370.018
positive regulation of immune system processGO:0002684680.018
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.018
response to alcoholGO:0097305950.018
cholesterol transportGO:003030120.017
regulation of cellular ketone metabolic processGO:001056530.017
respiratory system developmentGO:00605412130.017
tissue deathGO:00162711020.017
defense response to bacteriumGO:00427421780.017
Fly
negative regulation of neural precursor cell proliferationGO:2000178270.017
organic acid metabolic processGO:00060821030.016
dorsal ventral pattern formationGO:00099531330.016
organonitrogen compound metabolic processGO:19015643180.016
cholesterol homeostasisGO:004263230.016
phosphorylationGO:00163102940.016
cellular response to starvationGO:0009267610.016
salivary gland cell autophagic cell deathGO:0035071830.016
response to radiationGO:00093141550.016
positive regulation of transcription dna templatedGO:00458932660.015
steroid metabolic processGO:0008202200.015
segmentationGO:00352822070.015
cellular protein localizationGO:00346131600.015
positive regulation of gene expressionGO:00106282900.015
protein localizationGO:00081042840.015
positive regulation of nucleic acid templated transcriptionGO:19035082660.015
chemical homeostasisGO:0048878920.015
wound healingGO:0042060750.015
Rat
dorsal ventral axis specificationGO:0009950660.015
response to lipopolysaccharideGO:003249640.015
regulation of cell adhesionGO:0030155270.015
Rat
dendrite developmentGO:00163582040.015
embryo development ending in birth or egg hatchingGO:00097921520.015
positive regulation of cellular component organizationGO:00511301560.014
regulation of cell deathGO:00109411730.014
antimicrobial peptide productionGO:0002775460.014
Fly
protein complex biogenesisGO:00702712010.014
innate immune responseGO:00450871440.014
telencephalon developmentGO:002153720.014
positive regulation of rna metabolic processGO:00512542710.014
negative regulation of nitrogen compound metabolic processGO:00511722650.014
positive regulation of macromolecule metabolic processGO:00106044050.014
cognitionGO:00508901410.014
carboxylic acid metabolic processGO:0019752920.014
embryonic development via the syncytial blastodermGO:00017001480.013
oxidation reduction processGO:00551141230.013
regulation of transportGO:00510491810.013
positive regulation of multicellular organismal processGO:00512401430.013
synapse assemblyGO:00074161430.013
positive regulation of cell migrationGO:003033520.013
regulation of response to external stimulusGO:00321011150.013
Rat Fly
positive regulation of nucleobase containing compound metabolic processGO:00459353320.013
carbohydrate derivative catabolic processGO:19011361180.013
regulation of cellular protein metabolic processGO:00322682430.013
positive regulation of multi organism processGO:0043902400.013
cellular response to chemical stimulusGO:00708871990.013
aminoglycan metabolic processGO:0006022180.013
embryonic axis specificationGO:00005781070.013
cellular response to organic substanceGO:00713101320.013
histolysisGO:00075591020.013
regulation of cellular amide metabolic processGO:0034248390.013
response to organic cyclic compoundGO:0014070890.013
response to biotic stimulusGO:00096072940.013
Fly
anterior posterior axis specification embryoGO:00085951030.013
regulation of antimicrobial peptide productionGO:0002784440.013
Fly
regulation of secretion by cellGO:1903530390.013
negative regulation of molecular functionGO:0044092510.013
macromolecular complex assemblyGO:00650032560.012
response to endogenous stimulusGO:00097191190.012
dendrite morphogenesisGO:00488131990.012
taxisGO:00423303040.012
transcription from rna polymerase ii promoterGO:00063663680.012
male gamete generationGO:00482322010.012
salivary gland histolysisGO:0035070880.012
positive regulation of cell motilityGO:200014730.012
neurological system processGO:00508773580.012
mitotic spindle organizationGO:00070522200.012
protein localization to organelleGO:0033365820.012
negative regulation of cellular biosynthetic processGO:00313272770.012
protein polymerizationGO:0051258420.012
autophagic cell deathGO:0048102830.012
negative regulation of rna metabolic processGO:00512532510.012
cation homeostasisGO:0055080510.012
cell motilityGO:00488702510.012
negative regulation of cell developmentGO:0010721620.012
positive regulation of secretionGO:0051047220.011
positive regulation of defense responseGO:0031349590.011
amine metabolic processGO:0009308120.011
cellular response to external stimulusGO:0071496660.011
intracellular protein transportGO:00068861040.011
chromosome organizationGO:00512763600.011
anatomical structure homeostasisGO:0060249970.011
learningGO:0007612750.011
single organism intracellular transportGO:19025822070.011
regulation of anatomical structure sizeGO:00900661630.011
forebrain developmentGO:003090020.011
inter male aggressive behaviorGO:0002121600.011
spindle organizationGO:00070512530.011
negative regulation of nucleic acid templated transcriptionGO:19035072400.011
sterol homeostasisGO:005509240.011
cellular amino acid metabolic processGO:0006520610.011
regulation of cellular catabolic processGO:00313291570.011
establishment of protein localizationGO:00451841630.011
positive regulation of catabolic processGO:00098961050.010
peptide hormone processingGO:001648620.010
positive regulation of defense response to bacteriumGO:1900426230.010
detection of stimulusGO:00516061560.010
developmental maturationGO:00217001720.010
regulation of organ morphogenesisGO:2000027780.010
regulation of phosphate metabolic processGO:00192202100.010
regulation of lipid transportGO:003236830.010
associative learningGO:0008306650.010
cellular macromolecular complex assemblyGO:00346221530.010
response to organophosphorusGO:004668320.010
regulation of molecular functionGO:00650092170.010

Spn4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.053
disease of anatomical entityDOID:700.036
inherited metabolic disorderDOID:65500.013
nervous system diseaseDOID:86300.013
urinary system diseaseDOID:1800.012
acquired metabolic diseaseDOID:006015800.011