IMP: Integrative Multi-species Prediction

Drosophila melanogaster

220 known processes

Gap1 (Dmel_CG6721)

GTPase-activating protein 1

(Aliases: Dmel\CG6721,CG6721,gap1,Ras-GAP,Gap,GAP1,gap,sxt,rI533,Gap 1,mip,GAP,rasGAP)

Entrez: 39158
FLYBASE: FBgn0004390
UniProtKB: M9PF62
UniProtKB: P48423

Process Predictions
Disease Predictions

Gap1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
regulation of photoreceptor cell differentiation	GO:0046532	34	0.981
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.977
appendage development	GO:0048736	401	0.962
imaginal disc derived appendage development	GO:0048737	399	0.954
sensory organ morphogenesis	GO:0090596	260	0.951
tube development	GO:0035295	244	0.946
compound eye photoreceptor fate commitment	GO:0001752	36	0.940
regulation of cell differentiation	GO:0045595	302	0.935
compound eye photoreceptor cell differentiation	GO:0001751	140	0.918
protein acylation	GO:0043543	42	0.915
negative regulation of rna biosynthetic process	GO:1902679	240	0.904
photoreceptor cell differentiation	GO:0046530	170	0.891
negative regulation of cell differentiation	GO:0045596	143	0.890
eye photoreceptor cell differentiation	GO:0001754	145	0.884
compound eye cone cell fate commitment	GO:0042676	5	0.853
female meiosis chromosome segregation	GO:0016321	33	0.851
compound eye development	GO:0048749	307	0.815
negative regulation of transcription dna templated	GO:0045892	237	0.809
regulation of cell fate commitment	GO:0010453	29	0.806
positive regulation of macromolecule metabolic process	GO:0010604	405	0.803
chromosome organization	GO:0051276	360	0.747
eye photoreceptor cell fate commitment	GO:0042706	37	0.745
dorsal closure	GO:0007391	79	0.741
post embryonic appendage morphogenesis	GO:0035120	385	0.732
cell motility	GO:0048870	251	0.729
eye development	GO:0001654	323	0.707
r7 cell differentiation	GO:0045466	43	0.695
organonitrogen compound metabolic process	GO:1901564	318	0.687
wnt signaling pathway	GO:0016055	98	0.672
dorsal ventral axis specification ovarian follicular epithelium	GO:0008069	13	0.671
erbb signaling pathway	GO:0038127	58	0.662
cellular protein modification process	GO:0006464	438	0.647
positive regulation of rna metabolic process	GO:0051254	271	0.634
meiotic chromosome segregation	GO:0045132	59	0.623
compound eye morphogenesis	GO:0001745	249	0.617
digestive system development	GO:0055123	149	0.615
covalent chromatin modification	GO:0016569	106	0.605
appendage morphogenesis	GO:0035107	397	0.597
imaginal disc derived wing morphogenesis	GO:0007476	337	0.592
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.583
organonitrogen compound biosynthetic process	GO:1901566	117	0.581
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.574
immune response	GO:0006955	246	0.574
regulation of cell cycle	GO:0051726	291	0.569
cellular amino acid metabolic process	GO:0006520	61	0.558
peptidyl lysine acetylation	GO:0018394	39	0.547
photoreceptor cell fate commitment	GO:0046552	41	0.543
protein acetylation	GO:0006473	39	0.536
stem cell differentiation	GO:0048863	117	0.520
chromosome segregation	GO:0007059	157	0.506
brain development	GO:0007420	120	0.494
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.490
head development	GO:0060322	135	0.484
neuron projection guidance	GO:0097485	241	0.476
positive regulation of photoreceptor cell differentiation	GO:0046534	12	0.470
histone modification	GO:0016570	106	0.452
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.451
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.444
neuron fate commitment	GO:0048663	50	0.440
organic acid metabolic process	GO:0006082	103	0.437
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.418
heart development	GO:0007507	82	0.413
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.410
positive regulation of transcription dna templated	GO:0045893	266	0.406
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.386
axon development	GO:0061564	297	0.384
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.379
positive regulation of gene expression	GO:0010628	290	0.372
transcription from rna polymerase ii promoter	GO:0006366	368	0.368
positive regulation of signaling	GO:0023056	243	0.366
meiotic nuclear division	GO:0007126	151	0.355
negative regulation of cell cycle	GO:0045786	116	0.349
negative regulation of cellular metabolic process	GO:0031324	382	0.346
malpighian tubule development	GO:0072002	64	0.343
positive regulation of rna biosynthetic process	GO:1902680	266	0.338
nucleoside catabolic process	GO:0009164	112	0.337
regulation of r7 cell differentiation	GO:0045676	15	0.335
regulation of immune response	GO:0050776	118	0.325
organelle fission	GO:0048285	340	0.310
taxis	GO:0042330	304	0.309
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.309
positive regulation of cellular biosynthetic process	GO:0031328	316	0.306
stem cell maintenance	GO:0019827	67	0.306
negative regulation of developmental process	GO:0051093	201	0.301
cell fate specification	GO:0001708	71	0.295
regulation of neurogenesis	GO:0050767	158	0.294
regulation of apoptotic process	GO:0042981	130	0.289
chromosome condensation	GO:0030261	41	0.286
female meiotic division	GO:0007143	70	0.278
mitotic cell cycle phase transition	GO:0044772	138	0.278
cell cycle phase transition	GO:0044770	140	0.274
cellular amine metabolic process	GO:0044106	12	0.273
vesicle mediated transport	GO:0016192	381	0.273
internal peptidyl lysine acetylation	GO:0018393	38	0.271
wing disc morphogenesis	GO:0007472	344	0.271
negative regulation of cellular biosynthetic process	GO:0031327	277	0.262
regulation of cellular amino acid metabolic process	GO:0006521	0	0.257
negative regulation of cell death	GO:0060548	81	0.251
embryo development ending in birth or egg hatching	GO:0009792	152	0.250
regulation of cell cycle phase transition	GO:1901987	130	0.248
compound eye cone cell differentiation	GO:0042675	13	0.246
regulation of multicellular organismal development	GO:2000026	414	0.246
negative regulation of gene expression	GO:0010629	387	0.239
regulation of cell death	GO:0010941	173	0.237
digestive tract development	GO:0048565	149	0.233
meiotic cell cycle process	GO:1903046	132	0.230
regulation of anatomical structure morphogenesis	GO:0022603	242	0.226
dna conformation change	GO:0071103	105	0.226
negative regulation of biosynthetic process	GO:0009890	277	0.224
regulation of cellular protein metabolic process	GO:0032268	243	0.223
response to biotic stimulus	GO:0009607	294	0.219
negative regulation of neurogenesis	GO:0050768	53	0.209
positive regulation of intracellular signal transduction	GO:1902533	116	0.206
establishment of ommatidial planar polarity	GO:0042067	49	0.203
gonad development	GO:0008406	50	0.199
dendrite development	GO:0016358	204	0.195
negative regulation of rna metabolic process	GO:0051253	251	0.192
regulation of organ morphogenesis	GO:2000027	78	0.190
negative regulation of cell cycle phase transition	GO:1901988	103	0.189
regulation of erbb signaling pathway	GO:1901184	42	0.187
stress activated protein kinase signaling cascade	GO:0031098	55	0.187
protein targeting to nucleus	GO:0044744	51	0.186
dendrite morphogenesis	GO:0048813	199	0.185
photoreceptor cell development	GO:0042461	96	0.182
axon guidance	GO:0007411	233	0.182
response to other organism	GO:0051707	293	0.180
exocrine system development	GO:0035272	162	0.177
compound eye photoreceptor development	GO:0042051	78	0.177
amine metabolic process	GO:0009308	12	0.177
regulation of protein transport	GO:0051223	57	0.170
sex differentiation	GO:0007548	81	0.169
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.168
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.167
regulation of nervous system development	GO:0051960	248	0.165
regulation of jnk cascade	GO:0046328	40	0.164
positive regulation of cell communication	GO:0010647	250	0.163
positive regulation of multicellular organismal process	GO:0051240	143	0.162
regulation of phosphate metabolic process	GO:0019220	210	0.160
meiotic cell cycle	GO:0051321	171	0.159
regulation of protein acetylation	GO:1901983	7	0.158
response to oxygen containing compound	GO:1901700	200	0.157
positive regulation of phosphate metabolic process	GO:0045937	139	0.155
single organism nuclear import	GO:1902593	51	0.154
humoral immune response	GO:0006959	117	0.153
regulation of cell fate specification	GO:0042659	27	0.153
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.151
malpighian tubule morphogenesis	GO:0007443	44	0.149
ras protein signal transduction	GO:0007265	88	0.147
multi organism behavior	GO:0051705	175	0.146
nuclear migration	GO:0007097	20	0.144
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.141
ribonucleoside metabolic process	GO:0009119	127	0.141
single organism behavior	GO:0044708	391	0.136
positive regulation of protein localization to nucleus	GO:1900182	21	0.132
multicellular organismal reproductive behavior	GO:0033057	110	0.131
regulation of chromosome organization	GO:0033044	64	0.130
embryonic development via the syncytial blastoderm	GO:0001700	148	0.129
development of primary sexual characteristics	GO:0045137	50	0.129
regulation of mitotic cell cycle	GO:0007346	190	0.128
positive regulation of biosynthetic process	GO:0009891	316	0.128
reproductive structure development	GO:0048608	74	0.125
regulation of cellular ketone metabolic process	GO:0010565	3	0.125
mapk cascade	GO:0000165	107	0.125
establishment of planar polarity	GO:0001736	87	0.122
eggshell formation	GO:0030703	105	0.122
regulation of immune system process	GO:0002682	176	0.121
jnk cascade	GO:0007254	50	0.121
positive regulation of signal transduction	GO:0009967	223	0.119
positive regulation of immune response	GO:0050778	63	0.118
regulation of localization	GO:0032879	275	0.118
eggshell chorion gene amplification	GO:0007307	9	0.117
antimicrobial humoral response	GO:0019730	99	0.115
regulation of cell shape	GO:0008360	113	0.115
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.115
eggshell chorion assembly	GO:0007306	66	0.113
protein import into nucleus	GO:0006606	51	0.112
nucleocytoplasmic transport	GO:0006913	72	0.111
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.108
germ line stem cell maintenance	GO:0030718	50	0.107
spindle organization	GO:0007051	253	0.106
positive regulation of phosphorus metabolic process	GO:0010562	139	0.105
regulation of protein metabolic process	GO:0051246	256	0.105
regulation of cellular amine metabolic process	GO:0033238	3	0.105
regulation of transport	GO:0051049	181	0.103
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.102
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.100
eye photoreceptor cell development	GO:0042462	81	0.100
positive regulation of mapk cascade	GO:0043410	63	0.100
gland development	GO:0048732	191	0.099
epithelial cell development	GO:0002064	274	0.098
negative regulation of mitotic cell cycle	GO:0045930	109	0.098
regulation of intracellular transport	GO:0032386	64	0.097
eye morphogenesis	GO:0048592	260	0.096
cell death	GO:0008219	279	0.096
stem cell development	GO:0048864	79	0.095
cell fate determination	GO:0001709	91	0.093
nucleoside triphosphate metabolic process	GO:0009141	120	0.092
activation of protein kinase activity	GO:0032147	12	0.091
protein import	GO:0017038	55	0.089
dna amplification	GO:0006277	11	0.087
phosphorylation	GO:0016310	294	0.086
regulation of nucleocytoplasmic transport	GO:0046822	35	0.086
positive regulation of cellular protein metabolic process	GO:0032270	118	0.086
internal protein amino acid acetylation	GO:0006475	38	0.085
organelle localization	GO:0051640	148	0.085
regulation of cellular localization	GO:0060341	136	0.085
cell cycle g1 s phase transition	GO:0044843	31	0.083
organic substance catabolic process	GO:1901575	308	0.083
multi multicellular organism process	GO:0044706	123	0.082
positive regulation of response to stimulus	GO:0048584	323	0.081
chromatin organization	GO:0006325	207	0.079
spermatogenesis	GO:0007283	200	0.079
carboxylic acid metabolic process	GO:0019752	92	0.079
embryonic morphogenesis	GO:0048598	206	0.079
response to organic substance	GO:0010033	284	0.077
death	GO:0016265	284	0.077
defense response	GO:0006952	300	0.077
gland morphogenesis	GO:0022612	145	0.076
multi organism reproductive behavior	GO:0044705	121	0.076
oxoacid metabolic process	GO:0043436	103	0.075
nucleoside phosphate metabolic process	GO:0006753	162	0.074
protein localization to nucleus	GO:0034504	55	0.074
positive regulation of phosphorylation	GO:0042327	87	0.074
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.073
establishment of protein localization	GO:0045184	163	0.073
positive regulation of protein metabolic process	GO:0051247	128	0.070
developmental programmed cell death	GO:0010623	138	0.069
positive regulation of cell development	GO:0010720	61	0.069
organophosphate metabolic process	GO:0019637	195	0.069
regulation of protein localization to nucleus	GO:1900180	29	0.067
regulation of ras protein signal transduction	GO:0046578	93	0.067
regulation of intracellular protein transport	GO:0033157	46	0.066
positive regulation of catalytic activity	GO:0043085	118	0.065
tracheal outgrowth open tracheal system	GO:0007426	18	0.065
regulation of compound eye cone cell fate specification	GO:0042682	4	0.065
positive regulation of protein modification process	GO:0031401	58	0.065
carbohydrate derivative metabolic process	GO:1901135	217	0.063
reproductive behavior	GO:0019098	122	0.062
cell migration	GO:0016477	238	0.062
chorion containing eggshell formation	GO:0007304	105	0.061
regulation of cellular catabolic process	GO:0031329	157	0.061
body morphogenesis	GO:0010171	2	0.061
regulation of cell development	GO:0060284	215	0.061
axonogenesis	GO:0007409	290	0.060
regulation of protein import into nucleus	GO:0042306	28	0.060
negative regulation of intracellular signal transduction	GO:1902532	57	0.058
positive regulation of immune system process	GO:0002684	68	0.057
centrosome organization	GO:0051297	163	0.057
mitotic spindle organization	GO:0007052	220	0.057
rna polyadenylation	GO:0043631	12	0.056
locomotory behavior	GO:0007626	176	0.055
instar larval development	GO:0002168	55	0.055
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.055
response to radiation	GO:0009314	155	0.055
erk1 and erk2 cascade	GO:0070371	39	0.055
regulation of defense response	GO:0031347	102	0.054
stress activated mapk cascade	GO:0051403	52	0.053
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.053
posttranscriptional gene silencing	GO:0016441	46	0.053
apoptotic signaling pathway	GO:0097190	27	0.053
nucleobase containing small molecule metabolic process	GO:0055086	174	0.052
regulation of molecular function	GO:0065009	217	0.052
developmental growth	GO:0048589	280	0.051
response to gravity	GO:0009629	26	0.051
immune effector process	GO:0002252	98	0.050
mitotic sister chromatid segregation	GO:0000070	87	0.050
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.050
regulation of nucleotide metabolic process	GO:0006140	62	0.050
nuclear division	GO:0000280	332	0.049
response to external biotic stimulus	GO:0043207	293	0.048
negative regulation of cell communication	GO:0010648	223	0.048
regulation of apoptotic signaling pathway	GO:2001233	10	0.048
telencephalon development	GO:0021537	2	0.047
positive regulation of molecular function	GO:0044093	136	0.047
digestive tract morphogenesis	GO:0048546	127	0.047
larval behavior	GO:0030537	42	0.047
regulation of cytoplasmic transport	GO:1903649	47	0.047
positive regulation of developmental process	GO:0051094	143	0.046
immune system process	GO:0002376	347	0.046
ribonucleoside catabolic process	GO:0042454	112	0.046
negative regulation of cellular component organization	GO:0051129	108	0.046
somatic muscle development	GO:0007525	66	0.046
signal transduction by phosphorylation	GO:0023014	107	0.045
positive regulation of neuron apoptotic process	GO:0043525	1	0.045
programmed cell death	GO:0012501	257	0.044
branching involved in open tracheal system development	GO:0060446	45	0.044
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.043
purine nucleoside catabolic process	GO:0006152	112	0.043
regulation of purine nucleotide catabolic process	GO:0033121	48	0.043
positive regulation of nucleotide metabolic process	GO:0045981	55	0.043
immune response activating signal transduction	GO:0002757	2	0.042
nuclear import	GO:0051170	51	0.042
negative regulation of cell development	GO:0010721	62	0.042
endodermal cell fate commitment	GO:0001711	3	0.042
posttranscriptional gene silencing by rna	GO:0035194	45	0.042
central nervous system development	GO:0007417	201	0.042
negative regulation of phosphorus metabolic process	GO:0010563	45	0.041
regulation of cellular response to stress	GO:0080135	89	0.041
mrna processing	GO:0006397	104	0.040
negative regulation of gene expression epigenetic	GO:0045814	77	0.040
regulation of meiosis	GO:0040020	3	0.040
nuclear transport	GO:0051169	72	0.040
negative regulation of response to stimulus	GO:0048585	258	0.039
tube morphogenesis	GO:0035239	191	0.039
asymmetric cell division	GO:0008356	37	0.039
negative regulation of kinase activity	GO:0033673	16	0.039
regulation of catabolic process	GO:0009894	170	0.039
negative regulation of apoptotic signaling pathway	GO:2001234	5	0.039
regulation of proteolysis	GO:0030162	87	0.039
negative regulation of erk1 and erk2 cascade	GO:0070373	3	0.038
regulation of chromatin organization	GO:1902275	32	0.038
positive regulation of histone acetylation	GO:0035066	3	0.037
peptidyl amino acid modification	GO:0018193	105	0.037
purine ribonucleotide metabolic process	GO:0009150	145	0.037
positive regulation of protein phosphorylation	GO:0001934	34	0.037
nucleoside metabolic process	GO:0009116	127	0.037
peptidyl lysine modification	GO:0018205	57	0.037
regulation of innate immune response	GO:0045088	71	0.036
negative regulation of photoreceptor cell differentiation	GO:0046533	8	0.036
regulation of hydrolase activity	GO:0051336	97	0.036
negative regulation of neuroblast proliferation	GO:0007406	27	0.035
negative regulation of protein modification process	GO:0031400	29	0.035
regulation of histone modification	GO:0031056	20	0.035
salivary gland morphogenesis	GO:0007435	145	0.035
establishment of tissue polarity	GO:0007164	87	0.035
protein modification process	GO:0036211	438	0.035
negative regulation of cell cycle process	GO:0010948	109	0.035
regulation of cell cycle process	GO:0010564	181	0.035
regulation of purine nucleotide metabolic process	GO:1900542	62	0.034
regulation of protein targeting	GO:1903533	29	0.034
purine ribonucleoside metabolic process	GO:0046128	127	0.034
single organism biosynthetic process	GO:0044711	206	0.034
positive regulation of neurogenesis	GO:0050769	41	0.034
regulation of cell morphogenesis	GO:0022604	163	0.034
regulation of protein modification process	GO:0031399	112	0.033
renal tubule development	GO:0061326	64	0.033
cellular catabolic process	GO:0044248	372	0.033
larval development	GO:0002164	104	0.033
lateral inhibition	GO:0046331	206	0.033
localization of cell	GO:0051674	257	0.033
reproductive system development	GO:0061458	74	0.033
regulation of cell proliferation	GO:0042127	163	0.032
sister chromatid segregation	GO:0000819	92	0.032
regulation of chromatin modification	GO:1903308	28	0.032
ameboidal type cell migration	GO:0001667	151	0.032
membrane disassembly	GO:0030397	4	0.031
negative regulation of autophagy	GO:0010507	16	0.031
ribonucleotide metabolic process	GO:0009259	145	0.031
regulation of histone acetylation	GO:0035065	7	0.031
ommatidial rotation	GO:0016318	20	0.031
purine containing compound metabolic process	GO:0072521	155	0.030
gene silencing	GO:0016458	138	0.030
establishment of organelle localization	GO:0051656	122	0.030
circulatory system development	GO:0072359	82	0.029
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.029
histoblast morphogenesis	GO:0007488	9	0.029
regulation of synapse structure and activity	GO:0050803	128	0.028
response to fungus	GO:0009620	50	0.028
regulation of programmed cell death	GO:0043067	152	0.027
tissue death	GO:0016271	102	0.027
cellular respiration	GO:0045333	26	0.027
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.027
purine nucleotide metabolic process	GO:0006163	146	0.027
meiotic chromosome condensation	GO:0010032	3	0.026
negative regulation of programmed cell death	GO:0043069	72	0.026
cystoblast division	GO:0007282	10	0.025
segmentation	GO:0035282	207	0.025
establishment of nucleus localization	GO:0040023	26	0.025
positive regulation of nervous system development	GO:0051962	69	0.025
regulation of protein kinase activity	GO:0045859	51	0.025
r7 cell development	GO:0045467	14	0.025
gastrulation	GO:0007369	70	0.024
regulation of gene silencing	GO:0060968	63	0.024
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.024
dna biosynthetic process	GO:0071897	24	0.024
r7 cell fate commitment	GO:0007465	12	0.024
morphogenesis of an epithelium	GO:0002009	276	0.023
epithelial cell differentiation	GO:0030855	322	0.023
single organism catabolic process	GO:0044712	228	0.023
nucleotide metabolic process	GO:0009117	161	0.023
chemotaxis	GO:0006935	249	0.023
regulation of imaginal disc derived wing size	GO:0044719	20	0.023
germ line cyst formation	GO:0048134	44	0.022
regulation of establishment of protein localization	GO:0070201	61	0.022
positive regulation of cell differentiation	GO:0045597	64	0.022
regulation of immune effector process	GO:0002697	52	0.022
meiotic spindle organization	GO:0000212	36	0.022
regulation of organelle organization	GO:0033043	196	0.022
chemosensory behavior	GO:0007635	106	0.022
small molecule metabolic process	GO:0044281	305	0.022
dna packaging	GO:0006323	91	0.021
positive regulation of hydrolase activity	GO:0051345	78	0.021
mitotic dna damage checkpoint	GO:0044773	74	0.020
regulation of developmental growth	GO:0048638	174	0.020
positive regulation of jun kinase activity	GO:0043507	4	0.020
regulation of histone deacetylation	GO:0031063	2	0.020
regulation of compound eye retinal cell programmed cell death	GO:0046669	18	0.020
positive regulation of proteolysis	GO:0045862	52	0.020
regulation of transferase activity	GO:0051338	58	0.020
response to inorganic substance	GO:0010035	44	0.020
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.019
male gamete generation	GO:0048232	201	0.019
regulation of cellular component biogenesis	GO:0044087	201	0.019
organ growth	GO:0035265	56	0.019
rna processing	GO:0006396	147	0.019
response to endogenous stimulus	GO:0009719	119	0.019
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.019
tube fusion	GO:0035146	17	0.019
glycosyl compound metabolic process	GO:1901657	127	0.019
establishment of cell polarity	GO:0030010	40	0.019
biological adhesion	GO:0022610	138	0.019
regionalization	GO:0003002	416	0.018
proteolysis	GO:0006508	192	0.018
regulation of embryonic development	GO:0045995	68	0.018
olfactory behavior	GO:0042048	97	0.018
negative regulation of apoptotic process	GO:0043066	63	0.018
regulation of erk1 and erk2 cascade	GO:0070372	39	0.018
defense response to fungus	GO:0050832	48	0.017
positive regulation of cellular amine metabolic process	GO:0033240	0	0.017
glycosyl compound catabolic process	GO:1901658	112	0.017
small gtpase mediated signal transduction	GO:0007264	88	0.017
regulation of locomotion	GO:0040012	42	0.017
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.017
neuromuscular junction development	GO:0007528	149	0.017
salivary gland development	GO:0007431	162	0.017
response to nitrogen compound	GO:1901698	90	0.017
guanosine containing compound catabolic process	GO:1901069	74	0.017
negative regulation of cytoplasmic transport	GO:1903650	8	0.017
positive regulation of cellular catabolic process	GO:0031331	95	0.017
chromosome separation	GO:0051304	42	0.017
histolysis	GO:0007559	102	0.017
regulation of catalytic activity	GO:0050790	185	0.016
cell cycle arrest	GO:0007050	4	0.016
male meiosis	GO:0007140	52	0.016
endodermal cell differentiation	GO:0035987	3	0.016
chromatin modification	GO:0016568	147	0.016
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.016
negative regulation of signal transduction	GO:0009968	206	0.016
regulation of mrna processing	GO:0050684	71	0.016
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.016
negative regulation of cyclin dependent protein serine threonine kinase activity	GO:0045736	1	0.016
establishment of localization in cell	GO:0051649	402	0.016
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.016
rna interference	GO:0016246	27	0.016
endomembrane system organization	GO:0010256	119	0.016
regulation of phosphatase activity	GO:0010921	3	0.016
mitotic g2 m transition checkpoint	GO:0044818	70	0.016
regulation of chromosome segregation	GO:0051983	32	0.016
negative regulation of epithelial cell migration	GO:0010633	1	0.016
carbohydrate derivative biosynthetic process	GO:1901137	85	0.016
nucleoside triphosphate catabolic process	GO:0009143	108	0.015
regulation of gene expression epigenetic	GO:0040029	128	0.015
regulation of kinase activity	GO:0043549	53	0.015
regulation of wnt signaling pathway	GO:0030111	68	0.015
purine nucleotide catabolic process	GO:0006195	109	0.015
rho protein signal transduction	GO:0007266	14	0.015
negative regulation of epithelial cell proliferation	GO:0050680	4	0.015
intracellular transport	GO:0046907	228	0.014
response to hypoxia	GO:0001666	53	0.014
regulation of protein localization	GO:0032880	76	0.014
cellular protein complex assembly	GO:0043623	71	0.014
negative regulation of nervous system development	GO:0051961	92	0.014
protein ubiquitination	GO:0016567	70	0.014
lipid storage	GO:0019915	38	0.014
compound eye retinal cell programmed cell death	GO:0046667	23	0.014
renal tubule morphogenesis	GO:0061333	44	0.014
purine containing compound catabolic process	GO:0072523	112	0.014
synaptic growth at neuromuscular junction	GO:0051124	119	0.014
signal transduction in response to dna damage	GO:0042770	3	0.014
histone acetylation	GO:0016573	38	0.013
nephron development	GO:0072006	3	0.013
positive regulation of cell proliferation	GO:0008284	47	0.013
eye antennal disc development	GO:0035214	60	0.013
positive regulation of nucleoside metabolic process	GO:0045979	47	0.013
peripheral nervous system development	GO:0007422	52	0.013
negative regulation of cell proliferation	GO:0008285	69	0.013
fusion cell fate specification	GO:0035156	4	0.013
immune system development	GO:0002520	57	0.013
cell cycle checkpoint	GO:0000075	95	0.013
immune response regulating signaling pathway	GO:0002764	2	0.013
positive regulation of ras protein signal transduction	GO:0046579	43	0.013
intracellular signal transduction	GO:0035556	300	0.013
regulation of rna splicing	GO:0043484	69	0.013
regulation of intracellular signal transduction	GO:1902531	236	0.013
mushroom body development	GO:0016319	70	0.012
amide biosynthetic process	GO:0043604	42	0.012
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.012
response to bacterium	GO:0009617	198	0.012
branch fusion open tracheal system	GO:0035147	17	0.012
gene silencing by rna	GO:0031047	57	0.012
positive regulation of wnt signaling pathway	GO:0030177	25	0.012
protein phosphorylation	GO:0006468	169	0.012
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.012
regulation of multi organism process	GO:0043900	131	0.012

Gap1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.043
	cardiovascular system disease	DOID:1287	0	0.020

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