Drosophila melanogaster

145 known processes

hppy (Dmel_CG7097)

happyhour

(Aliases: MAP4K3,Dmel\CG7097,CG7097,GLK/KHS1,anon-WO0153538.68)

hppy biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of intracellular signal transductionGO:19025312360.542
regulation of immune system processGO:00026821760.473
regulation of growthGO:00400082330.463
lipid metabolic processGO:00066291210.445
developmental growthGO:00485892800.420
deathGO:00162652840.409
negative regulation of response to stimulusGO:00485852580.346
negative regulation of signalingGO:00230572190.321
negative regulation of signal transductionGO:00099682060.318
cellular protein modification processGO:00064644380.305
regulation of organ growthGO:0046620420.305
appendage developmentGO:00487364010.302
cellular ketone metabolic processGO:0042180240.275
regulation of response to stressGO:00801342000.272
multi organism behaviorGO:00517051750.272
negative regulation of cell communicationGO:00106482230.270
growthGO:00400073590.262
negative regulation of cellular metabolic processGO:00313243820.253
regulation of cellular amino acid metabolic processGO:000652100.232
cell cycle phase transitionGO:00447701400.215
tor signalingGO:0031929320.210
positive regulation of developmental growthGO:0048639620.203
regulation of developmental growthGO:00486381740.203
regulation of nervous system developmentGO:00519602480.201
response to nutrient levelsGO:00316671140.200
regulation of cellular amine metabolic processGO:003323830.199
protein modification processGO:00362114380.192
protein phosphorylationGO:00064681690.190
small molecule metabolic processGO:00442813050.181
cellular amino acid metabolic processGO:0006520610.169
positive regulation of response to stimulusGO:00485843230.159
ion transmembrane transportGO:00342201220.150
positive regulation of cell sizeGO:0045793210.147
signal transduction by phosphorylationGO:00230141070.144
intracellular signal transductionGO:00355563000.143
peptidyl threonine phosphorylationGO:001810720.140
regulation of cellular ketone metabolic processGO:001056530.140
positive regulation of growthGO:0045927750.136
purine nucleoside metabolic processGO:00422781270.130
cellular response to chemical stimulusGO:00708871990.130
cellular amine metabolic processGO:0044106120.128
positive regulation of developmental processGO:00510941430.128
negative regulation of nitrogen compound metabolic processGO:00511722650.128
vesicle mediated transportGO:00161923810.128
Mouse
cellular response to starvationGO:0009267610.125
cellular response to organic substanceGO:00713101320.121
regionalizationGO:00030024160.115
positive regulation of macromolecule metabolic processGO:00106044050.115
Human
single organism catabolic processGO:00447122280.110
multicellular organismal agingGO:00102591400.107
regulation of multicellular organism growthGO:0040014400.107
endocytosisGO:00068973100.107
actin filament based processGO:00300292200.107
negative regulation of synapse assemblyGO:0051964390.104
chemical homeostasisGO:0048878920.102
reproductive behaviorGO:00190981220.099
programmed cell deathGO:00125012570.098
carboxylic acid metabolic processGO:0019752920.097
purine ribonucleoside triphosphate metabolic processGO:00092051190.096
homeostatic processGO:00425921990.096
response to other organismGO:00517072930.096
regulation of anatomical structure sizeGO:00900661630.092
cellular response to external stimulusGO:0071496660.091
oxoacid metabolic processGO:00434361030.090
regulation of cellular component biogenesisGO:00440872010.090
imaginal disc derived appendage developmentGO:00487373990.089
intracellular transportGO:00469072280.088
organic cyclic compound catabolic processGO:19013611680.085
imaginal disc derived wing vein specificationGO:0007474480.083
regulation of epidermal growth factor receptor signaling pathwayGO:0042058420.083
regulation of cell deathGO:00109411730.080
regulation of transcription from rna polymerase ii promoterGO:00063573780.079
actin cytoskeleton organizationGO:00300362060.079
cell deathGO:00082192790.079
immune responseGO:00069552460.078
post embryonic appendage morphogenesisGO:00351203850.076
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092380.075
regulation of molecular functionGO:00650092170.074
Human
immune system processGO:00023763470.074
imaginal disc derived appendage morphogenesisGO:00351143950.074
positive regulation of cell communicationGO:00106472500.073
peptidyl amino acid modificationGO:00181931050.073
Human
adult behaviorGO:00305341370.073
positive regulation of signal transductionGO:00099672230.071
response to organic substanceGO:00100332840.069
negative regulation of gene expressionGO:00106293870.069
immune response regulating signaling pathwayGO:000276420.069
cholesterol homeostasisGO:004263230.068
peptide metabolic processGO:0006518800.068
purine nucleotide catabolic processGO:00061951090.067
cellular catabolic processGO:00442483720.066
gtp metabolic processGO:0046039720.065
nucleoside catabolic processGO:00091641120.065
establishment of localization in cellGO:00516494020.063
Mouse
regulation of cell cycleGO:00517262910.063
negative regulation of developmental growthGO:0048640640.063
erbb signaling pathwayGO:0038127580.063
organophosphate metabolic processGO:00196371950.063
cell proliferationGO:00082832990.062
Human
microtubule based transportGO:0010970420.062
organic acid metabolic processGO:00060821030.060
positive regulation of rna metabolic processGO:00512542710.060
regulation of multicellular organismal developmentGO:20000264140.060
regulation of epithelial cell proliferationGO:005067840.059
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.059
positive regulation of signalingGO:00230562430.059
cellular response to dna damage stimulusGO:00069742230.058
nucleoside triphosphate metabolic processGO:00091411200.058
multicellular organism growthGO:0035264460.057
amine metabolic processGO:0009308120.057
regulation of apoptotic processGO:00429811300.057
positive regulation of transcription dna templatedGO:00458932660.056
regulation of response to extracellular stimulusGO:0032104180.056
purine ribonucleoside triphosphate catabolic processGO:00092071080.055
autophagic vacuole assemblyGO:000004520.054
regulation of imaginal disc growthGO:0045570260.054
organelle assemblyGO:00709251980.054
small gtpase mediated signal transductionGO:0007264880.053
regulation of cellular protein metabolic processGO:00322682430.053
Human
positive regulation of cellular amine metabolic processGO:003324000.053
regulation of synapse structure and activityGO:00508031280.051
pigmentationGO:0043473750.050
organic substance transportGO:00717022570.050
positive regulation of cellular amino acid metabolic processGO:004576400.049
ribonucleoside triphosphate catabolic processGO:00092031080.049
appendage morphogenesisGO:00351073970.049
organelle fissionGO:00482853400.049
cellular response to nutrient levelsGO:0031669620.049
mitotic cell cycle phase transitionGO:00447721380.049
regulation of nucleotide catabolic processGO:0030811480.049
negative regulation of kinase activityGO:0033673160.049
positive regulation of nitrogen compound metabolic processGO:00511733540.048
positive regulation of nucleic acid templated transcriptionGO:19035082660.048
ion transportGO:00068111450.048
ribonucleoside triphosphate metabolic processGO:00091991190.047
regulation of erbb signaling pathwayGO:1901184420.047
regulation of synapse organizationGO:00508071100.046
single organism biosynthetic processGO:00447112060.046
positive regulation of cellular biosynthetic processGO:00313283160.046
response to alcoholGO:0097305950.045
regulation of macroautophagyGO:0016241150.045
imaginal disc growthGO:0007446370.045
enzyme linked receptor protein signaling pathwayGO:00071671790.044
chromatin organizationGO:00063252070.044
purine ribonucleoside metabolic processGO:00461281270.042
regulation of cellular catabolic processGO:00313291570.042
response to extracellular stimulusGO:00099911160.042
purine nucleoside triphosphate metabolic processGO:00091441190.042
regulation of gtpase activityGO:0043087440.042
negative regulation of intracellular signal transductionGO:1902532570.042
phosphorylationGO:00163102940.041
regulation of nucleoside metabolic processGO:0009118500.041
positive regulation of multicellular organismal processGO:00512401430.041
regulation of epidermal growth factor activated receptor activityGO:000717640.040
immune response activating signal transductionGO:000275720.040
regulation of neurogenesisGO:00507671580.040
hippo signalingGO:0035329200.040
regulation of cellular response to stressGO:0080135890.040
regulation of anatomical structure morphogenesisGO:00226032420.039
response to biotic stimulusGO:00096072940.039
defense responseGO:00069523000.039
organic substance catabolic processGO:19015753080.039
positive regulation of phosphate metabolic processGO:00459371390.039
aromatic compound catabolic processGO:00194391660.039
negative regulation of programmed cell deathGO:0043069720.038
cation transportGO:00068121100.038
imaginal disc derived wing morphogenesisGO:00074763370.038
regulation of cellular component sizeGO:0032535980.038
actin filament organizationGO:00070151260.037
purine nucleoside catabolic processGO:00061521120.037
cellular nitrogen compound catabolic processGO:00442701650.037
regulation of programmed cell deathGO:00430671520.036
chromosome organizationGO:00512763600.036
dna metabolic processGO:00062592270.036
positive regulation of intracellular signal transductionGO:19025331160.036
regulation of organelle organizationGO:00330431960.035
regulation of cellular localizationGO:00603411360.035
regulation of transportGO:00510491810.035
cell growthGO:00160491080.035
determination of adult lifespanGO:00083401370.035
cellular lipid metabolic processGO:0044255830.035
purine containing compound catabolic processGO:00725231120.035
response to external biotic stimulusGO:00432072930.034
synapse assemblyGO:00074161430.034
negative regulation of synaptic growth at neuromuscular junctionGO:0045886390.034
negative regulation of apoptotic processGO:0043066630.034
apoptotic processGO:00069151590.034
positive regulation of macromolecule biosynthetic processGO:00105572830.034
positive regulation of gene expressionGO:00106282900.034
protein complex assemblyGO:00064612000.034
regulation of phosphorylationGO:00423251470.033
mapk cascadeGO:00001651070.033
macroautophagyGO:0016236420.033
ras protein signal transductionGO:0007265880.033
nucleobase containing compound catabolic processGO:00346551650.032
phagocytosisGO:00069092150.032
wing disc morphogenesisGO:00074723440.032
positive regulation of cellular response to insulin stimulusGO:190007840.032
notch signaling pathwayGO:00072191200.032
innate immune response activating signal transductionGO:000275820.030
glycosyl compound catabolic processGO:19016581120.030
ribonucleotide metabolic processGO:00092591450.030
regulation of cell proliferationGO:00421271630.030
nucleoside triphosphate catabolic processGO:00091431080.030
heterochromatin organizationGO:0070828250.030
heterocycle catabolic processGO:00467001660.030
somatic muscle developmentGO:0007525660.030
response to abiotic stimulusGO:00096283410.030
Human
regulation of phosphorus metabolic processGO:00511742100.030
cellular homeostasisGO:0019725800.030
negative regulation of rna metabolic processGO:00512532510.029
negative regulation of cellular component organizationGO:00511291080.029
single organism intracellular transportGO:19025822070.029
ribose phosphate metabolic processGO:00196931450.029
regulation of defense responseGO:00313471020.029
nucleoside phosphate catabolic processGO:19012921100.029
gene silencingGO:00164581380.028
biological adhesionGO:00226101380.028
positive regulation of multicellular organism growthGO:0040018210.028
rubidium ion transportGO:003582610.028
negative regulation of protein tyrosine kinase activityGO:006109950.028
regulation of mitotic cell cycleGO:00073461900.028
spindle organizationGO:00070512530.028
compound eye photoreceptor developmentGO:0042051780.028
negative regulation of growthGO:0045926840.028
negative regulation of phosphatidylinositol 3 kinase signalingGO:001406740.027
phosphatidylinositol mediated signalingGO:004801540.027
erk1 and erk2 cascadeGO:0070371390.027
chromatin remodelingGO:0006338720.027
neuromuscular junction developmentGO:00075281490.026
organonitrogen compound metabolic processGO:19015643180.026
positive regulation of protein metabolic processGO:00512471280.026
Human
developmental cell growthGO:0048588520.025
organonitrogen compound catabolic processGO:19015651280.025
multi multicellular organism processGO:00447061230.025
translationGO:0006412690.025
regulation of response to nutrient levelsGO:0032107180.025
cellular protein catabolic processGO:0044257830.025
negative regulation of cell deathGO:0060548810.025
cell cycle checkpointGO:0000075950.025
regulation of phosphatase activityGO:001092130.025
multi organism reproductive behaviorGO:00447051210.024
establishment of organelle localizationGO:00516561220.024
Mouse
regulation of gene silencingGO:0060968630.024
triglyceride biosynthetic processGO:001943220.024
negative regulation of protein metabolic processGO:0051248850.024
organophosphate catabolic processGO:00464341120.024
rac protein signal transductionGO:001660130.024
organ growthGO:0035265560.024
protein modification by small protein conjugation or removalGO:00706471060.024
regulation of purine nucleotide catabolic processGO:0033121480.023
positive regulation of lipid catabolic processGO:005099610.023
macromolecular complex assemblyGO:00650032560.023
regulation of rac protein signal transductionGO:003502030.023
histolysisGO:00075591020.023
regulation of hydrolase activityGO:0051336970.023
positive regulation of rna biosynthetic processGO:19026802660.023
mitotic sister chromatid separationGO:0051306300.023
regulation of phosphate metabolic processGO:00192202100.023
cellular macromolecule catabolic processGO:00442651360.022
regulation of catalytic activityGO:00507901850.022
Human
response to endogenous stimulusGO:00097191190.022
regulation of cell divisionGO:0051302720.022
locomotory behaviorGO:00076261760.022
regulation of cytoplasmic transportGO:1903649470.022
head developmentGO:00603221350.022
purine nucleoside triphosphate catabolic processGO:00091461080.022
salivary gland cell autophagic cell deathGO:0035071830.022
single organism behaviorGO:00447083910.022
regulation of immune responseGO:00507761180.022
axon cargo transportGO:0008088290.022
regulation of cell sizeGO:0008361630.022
entry into diapauseGO:005511510.022
epidermal growth factor receptor signaling pathwayGO:0007173580.022
nucleoside metabolic processGO:00091161270.022
response to growth factorGO:0070848310.022
ribonucleoside catabolic processGO:00424541120.021
purine ribonucleoside catabolic processGO:00461301120.021
negative regulation of transferase activityGO:0051348180.021
positive regulation of cellular component organizationGO:00511301560.021
nucleotide catabolic processGO:00091661090.021
salivary gland histolysisGO:0035070880.021
positive regulation of molecular functionGO:00440931360.020
Human
regulation of vesicle mediated transportGO:0060627590.020
positive regulation of cellular protein metabolic processGO:00322701180.020
Human
regulation of localizationGO:00328792750.020
negative regulation of cellular biosynthetic processGO:00313272770.020
regulation of catabolic processGO:00098941700.020
regulation of peptidyl tyrosine phosphorylationGO:0050730100.020
response to starvationGO:0042594970.020
regulation of cell cycle phase transitionGO:19019871300.019
regulation of synapse assemblyGO:0051963940.019
regulation of insulin receptor signaling pathwayGO:0046626170.019
modification dependent macromolecule catabolic processGO:0043632790.019
regulation of notch signaling pathwayGO:00085931000.019
peptidyl threonine modificationGO:001821030.019
chromosome segregationGO:00070591570.019
positive regulation of cell deathGO:0010942690.019
regulation of imaginal disc derived wing sizeGO:0044719200.019
negative regulation of transcription dna templatedGO:00458922370.019
ribonucleotide catabolic processGO:00092611090.019
regulation of gtp catabolic processGO:0033124440.018
negative regulation of photoreceptor cell differentiationGO:004653380.018
tissue homeostasisGO:0001894360.018
regulation of translationGO:0006417560.018
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.018
regulation of cell differentiationGO:00455953020.018
regulation of ras protein signal transductionGO:0046578930.018
negative regulation of erbb signaling pathwayGO:1901185290.018
synaptic growth at neuromuscular junctionGO:00511241190.018
regulation of mapk cascadeGO:0043408920.018
negative regulation of macromolecule biosynthetic processGO:00105582700.018
cellular response to endogenous stimulusGO:0071495800.017
nuclear divisionGO:00002803320.017
wnt signaling pathwayGO:0016055980.017
striated muscle tissue developmentGO:0014706270.017
autophagic cell deathGO:0048102830.017
response to bacteriumGO:00096171980.017
body morphogenesisGO:001017120.017
macromolecule catabolic processGO:00090571610.017
regulation of protein modification processGO:00313991120.017
Human
protein catabolic processGO:00301631010.017
agingGO:00075681430.017
proteolysis involved in cellular protein catabolic processGO:0051603830.017
proteolysisGO:00065081920.017
tube developmentGO:00352952440.017
positive regulation of synaptic growth at neuromuscular junctionGO:0045887260.016
nuclear transcribed mrna catabolic processGO:0000956240.016
regulation of synaptic growth at neuromuscular junctionGO:0008582890.016
torc1 signalingGO:0038202120.016
activation of innate immune responseGO:000221840.016
negative regulation of biosynthetic processGO:00098902770.016
positive regulation of organ growthGO:0046622120.016
positive regulation of hydrolase activityGO:0051345780.016
positive regulation of biosynthetic processGO:00098913160.016
cell adhesionGO:00071551360.016
response to oxygen containing compoundGO:19017002000.016
negative regulation of peptidyl tyrosine phosphorylationGO:005073260.016
regulation of cell cycle processGO:00105641810.016
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178650.015
positive regulation of nucleobase containing compound metabolic processGO:00459353320.015
carbohydrate derivative catabolic processGO:19011361180.015
tissue deathGO:00162711020.015
transcription from rna polymerase ii promoterGO:00063663680.015
nucleobase containing small molecule metabolic processGO:00550861740.015
gastrulationGO:0007369700.015
response to oxidative stressGO:0006979860.015
er nucleus signaling pathwayGO:000698490.015
nucleoside phosphate metabolic processGO:00067531620.015
metal ion transportGO:0030001740.015
positive regulation of immune responseGO:0050778630.015
jak stat cascadeGO:0007259490.015
purine ribonucleotide catabolic processGO:00091541090.015
inositol lipid mediated signalingGO:004801740.014
posttranscriptional regulation of gene expressionGO:00106081450.014
anatomical structure homeostasisGO:0060249970.014
pattern recognition receptor signaling pathwayGO:000222120.014
negative regulation of erk1 and erk2 cascadeGO:007037330.014
developmental programmed cell deathGO:00106231380.014
negative regulation of multicellular organismal processGO:00512411420.014
regulation of cellular response to insulin stimulusGO:1900076170.014
synaptic vesicle localizationGO:0097479530.014
inorganic ion transmembrane transportGO:0098660730.014
larval developmentGO:00021641040.014
negative regulation of cellular protein metabolic processGO:0032269850.014
protein maturationGO:0051604710.014
transmembrane transportGO:00550851390.013
instar larval developmentGO:0002168550.013
ribonucleoside metabolic processGO:00091191270.013
negative regulation of notch signaling pathwayGO:0045746410.013
cytokinesisGO:0000910900.013
regulation of cell projection organizationGO:0031344920.013
regulation of neuron projection developmentGO:0010975690.013
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.013
cytoskeleton dependent intracellular transportGO:0030705440.013
regulation of mitotic sister chromatid segregationGO:0033047280.013
regulation of autophagyGO:0010506620.013
negative regulation of mapk cascadeGO:0043409230.013
response to copper ionGO:004668840.013
ion homeostasisGO:0050801550.013
secretion by cellGO:00329401010.013
secretionGO:00469031090.013
r8 cell fate specificationGO:004546450.013
regulation of protein metabolic processGO:00512462560.013
Human
negative regulation of phosphorus metabolic processGO:0010563450.013
limb developmentGO:006017310.013
cellular response to extracellular stimulusGO:0031668640.013
cell motilityGO:00488702510.013
decapentaplegic signaling pathwayGO:0008101190.012
multicellular organismal homeostasisGO:0048871410.012
negative regulation of epithelial cell proliferationGO:005068040.012
cell divisionGO:00513012480.012
limb morphogenesisGO:003510810.012
histone modificationGO:00165701060.012
circadian behaviorGO:0048512760.012
negative regulation of receptor activityGO:200027230.012
positive regulation of transportGO:0051050920.012
negative regulation of catalytic activityGO:0043086420.012
cellular response to molecule of bacterial originGO:007121930.012
negative regulation of cellular response to oxidative stressGO:190040810.012
regulation of response to external stimulusGO:00321011150.012
regulation of protein import into nucleusGO:0042306280.012
ubiquitin dependent protein catabolic processGO:0006511780.012
positive regulation of proteasomal protein catabolic processGO:1901800200.012
protein modification by small protein removalGO:0070646280.012
positive regulation of phosphorus metabolic processGO:00105621390.011
necrotic cell deathGO:007026510.011
eye developmentGO:00016543230.011
negative regulation of organelle organizationGO:0010639560.011
regulation of endocytosisGO:0030100370.011
tube morphogenesisGO:00352391910.011
lateral inhibitionGO:00463312060.011
positive regulation of cellular component biogenesisGO:0044089800.011
forebrain developmentGO:003090020.011
negative regulation of protein phosphorylationGO:0001933170.011
negative regulation of nucleobase containing compound metabolic processGO:00459342610.011
nucleotide metabolic processGO:00091171610.011
regulation of cellular response to oxidative stressGO:190040740.011
negative regulation of immune responseGO:0050777390.011
regulation of innate immune responseGO:0045088710.011
regulation of response to oxidative stressGO:190288240.011
localization of cellGO:00516742570.011
phosphatidylinositol 3 kinase signalingGO:001406540.011
meiotic nuclear divisionGO:00071261510.011
rhythmic behaviorGO:0007622760.011
positive regulation of insulin receptor signaling pathwayGO:004662830.011
proteasomal protein catabolic processGO:0010498590.011
positive regulation of protein modification processGO:0031401580.011
Human
regulation of hippo signalingGO:0035330140.011
imaginal disc pattern formationGO:0007447910.011
compound eye developmentGO:00487493070.011
negative regulation of cell differentiationGO:00455961430.011
negative regulation of cell proliferationGO:0008285690.011
hormone metabolic processGO:0042445330.011
sterol homeostasisGO:005509240.011
cellular response to biotic stimulusGO:007121640.010
regulation of nucleotide metabolic processGO:0006140620.010
endomembrane system organizationGO:00102561190.010
regulation of synaptic transmissionGO:0050804690.010
muscle structure developmentGO:00610612240.010
protein localizationGO:00081042840.010
purine containing compound metabolic processGO:00725211550.010
maintenance of locationGO:0051235730.010
regulation of decapentaplegic signaling pathwayGO:009009780.010
regulation of mitosisGO:0007088560.010
developmental pigmentationGO:0048066680.010

hppy disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.020
disease of cellular proliferationDOID:1456600.020
organ system cancerDOID:005068600.018
disease of anatomical entityDOID:700.018
cardiovascular system diseaseDOID:128700.013
disease of metabolismDOID:001466700.010
acquired metabolic diseaseDOID:006015800.010