IMP: Integrative Multi-species Prediction

Drosophila melanogaster

245 known processes

InR (Dmel_CG18402)

Insulin-like receptor

(Aliases: DIHR,Dir-b,Dir-a,inr,insulin/insulin-like growth factor receptor,InsR,dInR,l(3)93Dj,DIR,DILR,CG18402,l(3)05545,DIRbeta,Inr-alpha,INR,dInr,18402,dIRH,dIR,DInR,er10,dInsR,IR,DInr,DIRH,Inr-beta,l(3)er10,Dmel\CG18402,Inr,dINR,dir,dinr)

FLYBASE: FBgn0013984
Entrez: 42549
UniProtKB: P09208

Process Predictions
Disease Predictions

InR biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
growth	GO:0040007	359	0.999
learning or memory	GO:0007611	141	0.998	Fly
regulation of cell proliferation	GO:0042127	163	0.997
regulation of growth	GO:0040008	233	0.997
positive regulation of gene expression	GO:0010628	290	0.996
axon guidance	GO:0007411	233	0.995
cell proliferation	GO:0008283	299	0.994
negative regulation of cellular metabolic process	GO:0031324	382	0.992
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.991
circadian rhythm	GO:0007623	105	0.990
regulation of cell differentiation	GO:0045595	302	0.990	Fly
positive regulation of growth	GO:0045927	75	0.989
regulation of cell growth	GO:0001558	43	0.989
negative regulation of cell communication	GO:0010648	223	0.988	Human Mouse Fly
negative regulation of cellular biosynthetic process	GO:0031327	277	0.988
positive regulation of biosynthetic process	GO:0009891	316	0.988	Human Mouse Rat
taxis	GO:0042330	304	0.986
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.982	Human Rat
positive regulation of cellular biosynthetic process	GO:0031328	316	0.982	Human Mouse Rat
myotube differentiation	GO:0014902	46	0.979
positive regulation of cell migration	GO:0030335	2	0.977	Human
embryonic morphogenesis	GO:0048598	206	0.976
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.975
germ line stem cell division	GO:0042078	25	0.974
response to organic substance	GO:0010033	284	0.974
positive regulation of macromolecule metabolic process	GO:0010604	405	0.973	Human Mouse Rat Fly
positive regulation of rna biosynthetic process	GO:1902680	266	0.971
positive regulation of rna metabolic process	GO:0051254	271	0.969
negative regulation of signal transduction	GO:0009968	206	0.969	Human Mouse
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.968	Human Rat
positive regulation of developmental growth	GO:0048639	62	0.966
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.966
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.965
regulation of immune system process	GO:0002682	176	0.963	Fly
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.963
response to oxygen containing compound	GO:1901700	200	0.963
positive regulation of cellular response to insulin stimulus	GO:1900078	4	0.962
regulation of cellular localization	GO:0060341	136	0.961	Worm
positive regulation of response to stimulus	GO:0048584	323	0.957	Human Mouse Fly
cellular response to chemical stimulus	GO:0070887	199	0.956
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.953
photoreceptor cell differentiation	GO:0046530	170	0.949	Fly
developmental growth	GO:0048589	280	0.944
establishment of localization in cell	GO:0051649	402	0.942	Worm
aging	GO:0007568	143	0.939
feeding behavior	GO:0007631	50	0.935
single organism behavior	GO:0044708	391	0.935
positive regulation of transcription dna templated	GO:0045893	266	0.933
negative regulation of response to stimulus	GO:0048585	258	0.930
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.928
regulation of protein metabolic process	GO:0051246	256	0.924	Human Zebrafish Rat Fly
negative regulation of signaling	GO:0023057	219	0.924	Human Mouse Fly
cell death	GO:0008219	279	0.919	Human Zebrafish Rat
transcription from rna polymerase ii promoter	GO:0006366	368	0.918
cellular catabolic process	GO:0044248	372	0.918
dna metabolic process	GO:0006259	227	0.913	Human Rat
regulation of cell development	GO:0060284	215	0.908	Fly
multicellular organismal aging	GO:0010259	140	0.907
regulation of developmental growth	GO:0048638	174	0.906
immune response	GO:0006955	246	0.903	Human
chemotaxis	GO:0006935	249	0.903
rhythmic process	GO:0048511	106	0.900
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.900
brain development	GO:0007420	120	0.898	Mouse
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.897
regulation of catabolic process	GO:0009894	170	0.893
regulation of cellular catabolic process	GO:0031329	157	0.891
regulation of cell migration	GO:0030334	22	0.878	Human
positive regulation of lipid catabolic process	GO:0050996	1	0.875
negative regulation of cell proliferation	GO:0008285	69	0.873
single organism biosynthetic process	GO:0044711	206	0.870	Human Mouse Rat
regulation of apoptotic process	GO:0042981	130	0.866	Human Zebrafish Rat
imaginal disc derived appendage development	GO:0048737	399	0.864
central nervous system development	GO:0007417	201	0.864	Zebrafish Mouse
phosphorylation	GO:0016310	294	0.860
ameboidal type cell migration	GO:0001667	151	0.852
organic acid metabolic process	GO:0006082	103	0.848	Human
cell growth	GO:0016049	108	0.845
regulation of multicellular organism growth	GO:0040014	40	0.838
dendrite morphogenesis	GO:0048813	199	0.838
regulation of organelle organization	GO:0033043	196	0.836	Human Mouse Worm
skeletal muscle organ development	GO:0060538	48	0.826
organelle fission	GO:0048285	340	0.825	Human Mouse
response to oxidative stress	GO:0006979	86	0.825
multi organism reproductive behavior	GO:0044705	121	0.822
negative regulation of rna metabolic process	GO:0051253	251	0.822
imaginal disc derived wing morphogenesis	GO:0007476	337	0.816
regulation of phosphate metabolic process	GO:0019220	210	0.814	Human Mouse Rat Fly
response to peptide	GO:1901652	29	0.813
cardiac cell fate commitment	GO:0060911	17	0.812
cellular response to oxygen containing compound	GO:1901701	79	0.808
cellular response to peptide	GO:1901653	28	0.804
negative regulation of transcription dna templated	GO:0045892	237	0.802
death	GO:0016265	284	0.798	Human Zebrafish Rat
r7 cell differentiation	GO:0045466	43	0.793	Fly
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.784	Human Mouse Rat
appendage morphogenesis	GO:0035107	397	0.779
response to nitrogen compound	GO:1901698	90	0.771
positive regulation of developmental process	GO:0051094	143	0.765
regulation of cellular response to insulin stimulus	GO:1900076	17	0.740
cell motility	GO:0048870	251	0.738	Human Zebrafish
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.732
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.731
germ line stem cell maintenance	GO:0030718	50	0.723
negative regulation of rna biosynthetic process	GO:1902679	240	0.718
regulation of protein kinase activity	GO:0045859	51	0.713	Human Fly
appendage development	GO:0048736	401	0.711
regulation of cell cycle	GO:0051726	291	0.710	Human Mouse Rat
generation of precursor metabolites and energy	GO:0006091	42	0.704	Human Mouse
mitochondrion organization	GO:0007005	65	0.703
chromosome organization	GO:0051276	360	0.700
stem cell development	GO:0048864	79	0.694
positive regulation of cell differentiation	GO:0045597	64	0.689	Fly
axonogenesis	GO:0007409	290	0.671
response to organonitrogen compound	GO:0010243	75	0.670
positive regulation of cell motility	GO:2000147	3	0.661	Human
positive regulation of lipid metabolic process	GO:0045834	4	0.649	Rat
cellular response to hormone stimulus	GO:0032870	44	0.644
tube morphogenesis	GO:0035239	191	0.643	Zebrafish
regulation of stem cell proliferation	GO:0072091	40	0.640
cell division	GO:0051301	248	0.633
regulation of cellular protein metabolic process	GO:0032268	243	0.627	Human Zebrafish Rat Fly
stem cell proliferation	GO:0072089	88	0.622
epithelial cell migration	GO:0010631	148	0.621
regulation of nervous system development	GO:0051960	248	0.620	Fly
syncytium formation	GO:0006949	43	0.617
single organism cellular localization	GO:1902580	180	0.612	Worm
oocyte development	GO:0048599	124	0.609
meiotic cell cycle	GO:0051321	171	0.608
stem cell division	GO:0017145	69	0.605
immune system process	GO:0002376	347	0.604	Human Fly
compound eye photoreceptor cell differentiation	GO:0001751	140	0.604	Fly
small molecule metabolic process	GO:0044281	305	0.603	Human
response to ketone	GO:1901654	34	0.599	Rat
regulation of cell size	GO:0008361	63	0.597
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.597
organ growth	GO:0035265	56	0.596
cognition	GO:0050890	141	0.585	Fly
regulation of r7 cell differentiation	GO:0045676	15	0.585	Fly
neuron projection guidance	GO:0097485	241	0.584
negative regulation of molecular function	GO:0044092	51	0.577	Human Zebrafish Mouse Rat
cellular carbohydrate metabolic process	GO:0044262	22	0.577	Human Mouse
heart development	GO:0007507	82	0.572	Human Zebrafish
forebrain development	GO:0030900	2	0.571
response to wounding	GO:0009611	94	0.569	Zebrafish
dendrite development	GO:0016358	204	0.566
regulation of neurogenesis	GO:0050767	158	0.564	Fly
organic substance catabolic process	GO:1901575	308	0.563	Human
negative regulation of biosynthetic process	GO:0009890	277	0.558
axon development	GO:0061564	297	0.555
response to light stimulus	GO:0009416	124	0.551
regulation of localization	GO:0032879	275	0.546	Human Rat Worm
positive regulation of cell communication	GO:0010647	250	0.546	Human Mouse Fly
positive regulation of phosphorus metabolic process	GO:0010562	139	0.545	Human Mouse Rat Fly
negative regulation of cell fate specification	GO:0009996	15	0.543
positive regulation of lipid biosynthetic process	GO:0046889	3	0.542	Rat
regulation of phosphorus metabolic process	GO:0051174	210	0.540	Human Mouse Rat Fly
regulation of kinase activity	GO:0043549	53	0.538	Human Fly
imaginal disc growth	GO:0007446	37	0.537
positive regulation of cell growth	GO:0030307	19	0.532
negative regulation of growth	GO:0045926	84	0.529
multi organism behavior	GO:0051705	175	0.528
response to abiotic stimulus	GO:0009628	341	0.526
oxoacid metabolic process	GO:0043436	103	0.526	Human
ribose phosphate metabolic process	GO:0019693	145	0.520
negative regulation of catalytic activity	GO:0043086	42	0.517	Human Zebrafish
regulation of lipid biosynthetic process	GO:0046890	6	0.513	Rat
positive regulation of signaling	GO:0023056	243	0.510	Human Mouse Fly
neuroblast proliferation	GO:0007405	74	0.509
regulation of phosphorylation	GO:0042325	147	0.509	Human Mouse Rat Fly
positive regulation of signal transduction	GO:0009967	223	0.508	Human Mouse Fly
olfactory behavior	GO:0042048	97	0.507	Fly
regulation of cell death	GO:0010941	173	0.503	Human Zebrafish Rat
cell fate specification	GO:0001708	71	0.502	Fly
chemical homeostasis	GO:0048878	92	0.500	Human Rat
response to external biotic stimulus	GO:0043207	293	0.498
establishment or maintenance of cell polarity	GO:0007163	167	0.496	Rat Fly
determination of adult lifespan	GO:0008340	137	0.492
eye photoreceptor cell differentiation	GO:0001754	145	0.492	Fly
protein phosphorylation	GO:0006468	169	0.489
positive regulation of cell proliferation	GO:0008284	47	0.486
muscle structure development	GO:0061061	224	0.483
stem cell differentiation	GO:0048863	117	0.481
regulation of multicellular organismal development	GO:2000026	414	0.481	Human Fly
response to alcohol	GO:0097305	95	0.473	Rat
mitotic cell cycle phase transition	GO:0044772	138	0.471
negative regulation of intracellular signal transduction	GO:1902532	57	0.470	Human Mouse
oocyte differentiation	GO:0009994	145	0.469
actin filament based process	GO:0030029	220	0.466	Human
positive regulation of organelle organization	GO:0010638	65	0.460	Human Mouse
positive regulation of multicellular organismal process	GO:0051240	143	0.459
cellular response to nitrogen compound	GO:1901699	51	0.457
positive regulation of neurogenesis	GO:0050769	41	0.456	Fly
entry into diapause	GO:0055115	1	0.451	Worm
tor signaling	GO:0031929	32	0.450
dorsal ventral pattern formation	GO:0009953	133	0.449
regulation of protein phosphorylation	GO:0001932	64	0.447	Human Rat Fly
neurological system process	GO:0050877	358	0.446	Fly
regulation of photoreceptor cell differentiation	GO:0046532	34	0.445	Fly
negative regulation of cell cycle	GO:0045786	116	0.442
cyclic nucleotide metabolic process	GO:0009187	28	0.442
negative regulation of phosphorylation	GO:0042326	35	0.432	Human Mouse Rat
developmental maturation	GO:0021700	172	0.431
compound eye photoreceptor development	GO:0042051	78	0.428	Fly
response to peptide hormone	GO:0043434	29	0.414
lipid metabolic process	GO:0006629	121	0.412
maintenance of location	GO:0051235	73	0.410	Worm
negative regulation of gene expression	GO:0010629	387	0.410	Zebrafish Rat
myoblast fusion	GO:0007520	43	0.403
synaptic growth at neuromuscular junction	GO:0051124	119	0.398
tissue migration	GO:0090130	155	0.394
regulation of neuron differentiation	GO:0045664	103	0.391	Fly
cellular response to dna damage stimulus	GO:0006974	223	0.389
regulation of epithelial cell proliferation	GO:0050678	4	0.384
cell maturation	GO:0048469	144	0.382
positive regulation of protein metabolic process	GO:0051247	128	0.379	Human Rat Fly
regulation of anatomical structure size	GO:0090066	163	0.378
negative regulation of cell differentiation	GO:0045596	143	0.377
protein catabolic process	GO:0030163	101	0.374
cellular response to endogenous stimulus	GO:0071495	80	0.373
lipid homeostasis	GO:0055088	33	0.365
regulation of lipid metabolic process	GO:0019216	15	0.359	Rat
malpighian tubule morphogenesis	GO:0007443	44	0.357
regulation of protein modification process	GO:0031399	112	0.357	Human Rat Fly
regulation of dna metabolic process	GO:0051052	34	0.356	Human Rat
rhythmic behavior	GO:0007622	76	0.355
cellular response to organic substance	GO:0071310	132	0.353
autophagy	GO:0006914	108	0.352
insulin receptor signaling pathway	GO:0008286	25	0.346
regulation of programmed cell death	GO:0043067	152	0.345	Human Zebrafish Rat
mesoderm development	GO:0007498	78	0.344	Fly
regulation of dendrite morphogenesis	GO:0048814	28	0.340
epithelial cell development	GO:0002064	274	0.339
semaphorin plexin signaling pathway	GO:0071526	4	0.335
regulation of cellular ketone metabolic process	GO:0010565	3	0.333
negative regulation of kinase activity	GO:0033673	16	0.333	Human
response to lipopolysaccharide	GO:0032496	4	0.332
cell fate determination	GO:0001709	91	0.332
energy derivation by oxidation of organic compounds	GO:0015980	32	0.330	Human Mouse
catabolic process	GO:0009056	409	0.328
negative regulation of cell cycle process	GO:0010948	109	0.328
eye photoreceptor cell development	GO:0042462	81	0.327	Fly
cellular amino acid metabolic process	GO:0006520	61	0.327
negative regulation of multicellular organismal process	GO:0051241	142	0.326
morphogenesis of a branching epithelium	GO:0061138	45	0.323
cell migration	GO:0016477	238	0.323	Human Zebrafish
meiotic nuclear division	GO:0007126	151	0.322
response to endogenous stimulus	GO:0009719	119	0.317
open tracheal system development	GO:0007424	204	0.317
positive regulation of glycogen biosynthetic process	GO:0045725	1	0.312	Human Mouse
regulation of neuroblast proliferation	GO:1902692	34	0.310
regulation of immune response	GO:0050776	118	0.308
regulation of response to stress	GO:0080134	200	0.308	Human Worm
purine ribonucleotide biosynthetic process	GO:0009152	28	0.308
positive regulation of cell death	GO:0010942	69	0.308
pigment metabolic process	GO:0042440	84	0.306
striated muscle cell differentiation	GO:0051146	90	0.301
localization of cell	GO:0051674	257	0.299	Human Zebrafish
humoral immune response	GO:0006959	117	0.292
regulation of muscle organ development	GO:0048634	13	0.284
stem cell maintenance	GO:0019827	67	0.283
dormancy process	GO:0022611	2	0.283	Worm
regulation of neural precursor cell proliferation	GO:2000177	35	0.283
asymmetric stem cell division	GO:0098722	49	0.282
regulation of insulin receptor signaling pathway	GO:0046626	17	0.277
positive regulation of phosphorylation	GO:0042327	87	0.277	Human Mouse Rat Fly
sensory organ morphogenesis	GO:0090596	260	0.275	Zebrafish Fly
response to biotic stimulus	GO:0009607	294	0.270
regulation of catalytic activity	GO:0050790	185	0.269	Human Zebrafish Fly
positive regulation of programmed cell death	GO:0043068	62	0.267
programmed cell death	GO:0012501	257	0.266	Human Zebrafish Rat
signal transduction by phosphorylation	GO:0023014	107	0.266	Human Mouse Fly
organonitrogen compound metabolic process	GO:1901564	318	0.265
regulation of response to external stimulus	GO:0032101	115	0.259	Worm
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.258
digestive system development	GO:0055123	149	0.258	Mouse Fly
regionalization	GO:0003002	416	0.256	Zebrafish
regulation of striated muscle tissue development	GO:0016202	5	0.252
cellular amine metabolic process	GO:0044106	12	0.250
macromolecule catabolic process	GO:0009057	161	0.248
positive regulation of catabolic process	GO:0009896	105	0.248	Human
regulation of embryonic development	GO:0045995	68	0.247	Human
regulation of cell cycle phase transition	GO:1901987	130	0.246
response to insulin	GO:0032868	29	0.245
regulation of organ growth	GO:0046620	42	0.245
response to organic cyclic compound	GO:0014070	89	0.244
eye morphogenesis	GO:0048592	260	0.243	Fly
cellular response to insulin stimulus	GO:0032869	28	0.242
response to monosaccharide	GO:0034284	4	0.239	Rat
peptidyl threonine phosphorylation	GO:0018107	2	0.236
response to hexose	GO:0009746	3	0.236	Rat
regulation of protein localization	GO:0032880	76	0.234	Worm
regulation of behavior	GO:0050795	75	0.233
response to hormone	GO:0009725	45	0.231
syncytium formation by plasma membrane fusion	GO:0000768	43	0.229
regulation of hormone levels	GO:0010817	40	0.227	Rat
apoptotic process	GO:0006915	159	0.226	Human Zebrafish Rat
positive regulation of cell development	GO:0010720	61	0.223	Fly
embryonic development via the syncytial blastoderm	GO:0001700	148	0.219
negative regulation of protein metabolic process	GO:0051248	85	0.216	Human Zebrafish Rat
neuron fate commitment	GO:0048663	50	0.212	Fly
wing disc morphogenesis	GO:0007472	344	0.212
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.211
regulation of imaginal disc growth	GO:0045570	26	0.208
head development	GO:0060322	135	0.208	Mouse
cardioblast differentiation	GO:0010002	20	0.207
regulation of protein transport	GO:0051223	57	0.204	Worm
negative regulation of programmed cell death	GO:0043069	72	0.202	Human Zebrafish Rat
regulation of ras protein signal transduction	GO:0046578	93	0.201
mating	GO:0007618	120	0.201
ras protein signal transduction	GO:0007265	88	0.198
response to bacterium	GO:0009617	198	0.197
protein targeting to nucleus	GO:0044744	51	0.197	Worm
associative learning	GO:0008306	65	0.196	Fly
adult chitin containing cuticle pigmentation	GO:0048085	16	0.196
translation	GO:0006412	69	0.193
embryonic hemopoiesis	GO:0035162	26	0.193
skeletal muscle tissue development	GO:0007519	13	0.193
regulation of malpighian tubule diameter	GO:0035297	3	0.192
negative regulation of insulin secretion	GO:0046676	1	0.192
genital disc development	GO:0035215	44	0.190
lipid biosynthetic process	GO:0008610	46	0.189	Rat
exocrine system development	GO:0035272	162	0.188	Mouse
single organismal cell cell adhesion	GO:0016337	45	0.187
skeletal muscle fiber development	GO:0048741	3	0.185
intracellular transport	GO:0046907	228	0.184	Worm
hemopoiesis	GO:0030097	46	0.182
regulation of locomotion	GO:0040012	42	0.181	Human
response to radiation	GO:0009314	155	0.178
biological adhesion	GO:0022610	138	0.177
learning	GO:0007612	75	0.175	Fly
response to glucose	GO:0009749	2	0.173	Rat
regulation of cell motility	GO:2000145	23	0.173	Human
positive regulation of cellular protein metabolic process	GO:0032270	118	0.173	Human Fly
positive regulation of protein phosphorylation	GO:0001934	34	0.171	Human Fly
post embryonic appendage morphogenesis	GO:0035120	385	0.171
intracellular signal transduction	GO:0035556	300	0.171	Human Mouse Fly
circulatory system development	GO:0072359	82	0.170	Human Zebrafish
male gamete generation	GO:0048232	201	0.170
chemosensory behavior	GO:0007635	106	0.169	Fly
circulatory system process	GO:0003013	37	0.168
cell cycle phase transition	GO:0044770	140	0.167
myotube cell development	GO:0014904	3	0.167
regulation of epithelial cell migration	GO:0010632	12	0.166
negative regulation of photoreceptor cell differentiation	GO:0046533	8	0.166
malpighian tubule development	GO:0072002	64	0.164
chromatin organization	GO:0006325	207	0.163
cellular protein modification process	GO:0006464	438	0.162
positive regulation of muscle organ development	GO:0048636	6	0.160
carboxylic acid metabolic process	GO:0019752	92	0.160	Human
oocyte axis specification	GO:0007309	108	0.160
homeostatic process	GO:0042592	199	0.159
regulation of mitotic cell cycle	GO:0007346	190	0.154	Human Mouse
synapse assembly	GO:0007416	143	0.151
photoreceptor cell development	GO:0042461	96	0.150	Fly
cytoplasmic transport	GO:0016482	130	0.149	Worm
g protein coupled receptor signaling pathway	GO:0007186	136	0.149	Human
regulation of cell fate commitment	GO:0010453	29	0.148
anterior posterior pattern specification	GO:0009952	136	0.147	Zebrafish
organophosphate biosynthetic process	GO:0090407	46	0.146
response to other organism	GO:0051707	293	0.146
regulation of response to nutrient levels	GO:0032107	18	0.145	Worm
cellular response to organonitrogen compound	GO:0071417	36	0.144
regulation of chemotaxis	GO:0050920	12	0.142
regulation of establishment of protein localization	GO:0070201	61	0.142	Worm
positive regulation of cellular component organization	GO:0051130	156	0.141	Human Mouse
regulation of protein serine threonine kinase activity	GO:0071900	25	0.141	Human Fly
regulation of intracellular protein transport	GO:0033157	46	0.139	Worm
regulation of cellular component movement	GO:0051270	42	0.138	Human
positive regulation of apoptotic process	GO:0043065	47	0.137
negative regulation of apoptotic process	GO:0043066	63	0.137	Human Zebrafish Rat
locomotor rhythm	GO:0045475	56	0.135
immune system development	GO:0002520	57	0.135
digestive tract development	GO:0048565	149	0.135	Fly
protein localization to organelle	GO:0033365	82	0.134	Worm
response to ethanol	GO:0045471	59	0.134	Rat
positive regulation of molecular function	GO:0044093	136	0.134	Human Fly
response to uv	GO:0009411	24	0.134
pigmentation	GO:0043473	75	0.132
positive regulation of nervous system development	GO:0051962	69	0.130	Fly
response to oxygen levels	GO:0070482	59	0.129
cellular glucan metabolic process	GO:0006073	6	0.128	Human Mouse
spermatogenesis	GO:0007283	200	0.127
tripartite regional subdivision	GO:0007351	103	0.126
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.126
neuron death	GO:0070997	27	0.125
mesoderm morphogenesis	GO:0048332	22	0.124
cell type specific apoptotic process	GO:0097285	38	0.124	Rat
positive regulation of pathway restricted smad protein phosphorylation	GO:0010862	1	0.124
negative regulation of neuroblast proliferation	GO:0007406	27	0.122
regulation of tor signaling	GO:0032006	21	0.121
small gtpase mediated signal transduction	GO:0007264	88	0.121
regulation of transport	GO:0051049	181	0.120	Human Rat Worm
lipid localization	GO:0010876	54	0.120	Worm
locomotory behavior	GO:0007626	176	0.120
positive regulation of protein modification process	GO:0031401	58	0.120	Human Fly
regulation of glucan biosynthetic process	GO:0010962	1	0.119	Human Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.119
cell projection assembly	GO:0030031	94	0.118
establishment of protein localization to organelle	GO:0072594	62	0.118	Worm
negative regulation of mitotic cell cycle	GO:0045930	109	0.117
negative regulation of insulin receptor signaling pathway	GO:0046627	11	0.117
activation of protein kinase activity	GO:0032147	12	0.117	Human Fly
regulation of cell cycle process	GO:0010564	181	0.116	Human Mouse Rat
gastrulation	GO:0007369	70	0.116
negative regulation of cell migration	GO:0030336	5	0.115
developmental pigmentation	GO:0048066	68	0.113
chorion containing eggshell formation	GO:0007304	105	0.113
cellular response to lipopolysaccharide	GO:0071222	3	0.112
regulation of transferase activity	GO:0051338	58	0.111	Human Fly
regulation of pathway restricted smad protein phosphorylation	GO:0060393	1	0.111
regulation of heart contraction	GO:0008016	21	0.111
epithelial cell migration open tracheal system	GO:0007427	32	0.111
regulation of cellular component size	GO:0032535	98	0.111
response to extracellular stimulus	GO:0009991	116	0.110	Rat Worm
regulation of autophagy	GO:0010506	62	0.110
epithelium migration	GO:0090132	148	0.110
regulation of sequence specific dna binding transcription factor activity	GO:0051090	12	0.107	Mouse
nucleobase containing small molecule metabolic process	GO:0055086	174	0.107
positive regulation of cellular catabolic process	GO:0031331	95	0.107	Human
regulation of map kinase activity	GO:0043405	17	0.106	Human Fly
positive regulation of cell size	GO:0045793	21	0.106
memory	GO:0007613	94	0.105
positive regulation of behavior	GO:0048520	19	0.104
defense response	GO:0006952	300	0.103
positive regulation of phosphate metabolic process	GO:0045937	139	0.103	Human Mouse Rat Fly
regulation of cellular amino acid metabolic process	GO:0006521	0	0.102
blood circulation	GO:0008015	26	0.102
cytoplasm organization	GO:0007028	64	0.101
regulation of cell division	GO:0051302	72	0.100	Human Mouse Rat
cellular response to peptide hormone stimulus	GO:0071375	28	0.100
negative regulation of cell death	GO:0060548	81	0.100	Human Zebrafish Rat
regulation of nuclear division	GO:0051783	58	0.099	Human Mouse
somatic muscle development	GO:0007525	66	0.099
cell activation	GO:0001775	9	0.099
organophosphate metabolic process	GO:0019637	195	0.098
response to lipid	GO:0033993	38	0.097	Rat
muscle organ development	GO:0007517	127	0.097	Fly
telencephalon development	GO:0021537	2	0.096
neural precursor cell proliferation	GO:0061351	75	0.096
axis specification	GO:0009798	167	0.096
regulation of cellular amine metabolic process	GO:0033238	3	0.095
blastoderm segmentation	GO:0007350	159	0.095
response to hypoxia	GO:0001666	53	0.095
negative regulation of developmental growth	GO:0048640	64	0.094
ribonucleotide metabolic process	GO:0009259	145	0.094
protein complex biogenesis	GO:0070271	201	0.094	Human Rat
protein import into nucleus	GO:0006606	51	0.094	Worm
extrinsic apoptotic signaling pathway	GO:0097191	1	0.092
cellular ketone metabolic process	GO:0042180	24	0.092
cellular response to organic cyclic compound	GO:0071407	32	0.091
embryonic axis specification	GO:0000578	107	0.090
lateral inhibition	GO:0046331	206	0.089
regulation of intracellular transport	GO:0032386	64	0.088	Worm
negative regulation of epithelial cell migration	GO:0010633	1	0.088
carbohydrate metabolic process	GO:0005975	82	0.087
carbohydrate derivative metabolic process	GO:1901135	217	0.086	Rat
negative regulation of autophagy	GO:0010507	16	0.085
border follicle cell migration	GO:0007298	113	0.085
single organism catabolic process	GO:0044712	228	0.085	Human Worm
nuclear transport	GO:0051169	72	0.084	Worm
regulation of carbohydrate metabolic process	GO:0006109	10	0.083	Human Mouse
negative regulation of epithelial cell proliferation	GO:0050680	4	0.083
regulation of synapse structure and activity	GO:0050803	128	0.082
cell cycle g1 s phase transition	GO:0044843	31	0.082
germ band shortening	GO:0007390	19	0.081
regulation of chromosome organization	GO:0033044	64	0.081
heart contraction	GO:0060047	26	0.081
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.080
positive regulation of immune system process	GO:0002684	68	0.080
regulation of cellular component biogenesis	GO:0044087	201	0.080	Worm
proteolysis	GO:0006508	192	0.080	Zebrafish
axon midline choice point recognition	GO:0016199	26	0.080
cellular response to lipid	GO:0071396	20	0.079
regulation of multi organism process	GO:0043900	131	0.079
heart process	GO:0003015	37	0.079
gland development	GO:0048732	191	0.079	Mouse
negative regulation of cellular component organization	GO:0051129	108	0.077
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.076
antimicrobial humoral response	GO:0019730	99	0.075
negative regulation of developmental process	GO:0051093	201	0.073
regulation of molecular function	GO:0065009	217	0.073	Human Zebrafish Mouse Rat Fly
eye pigmentation	GO:0048069	43	0.072
regulation of dendrite development	GO:0050773	37	0.072
hindgut morphogenesis	GO:0007442	58	0.071
negative regulation of gene expression epigenetic	GO:0045814	77	0.071
activin receptor signaling pathway	GO:0032924	6	0.071
positive regulation of nitric oxide biosynthetic process	GO:0045429	1	0.071	Human
anterior posterior axis specification	GO:0009948	109	0.071
hematopoietic or lymphoid organ development	GO:0048534	57	0.070
negative regulation of stem cell proliferation	GO:2000647	30	0.070
positive regulation of mitotic cell cycle	GO:0045931	34	0.069	Human Mouse
organic hydroxy compound metabolic process	GO:1901615	83	0.069
reactive oxygen species metabolic process	GO:0072593	22	0.068

InR disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	acquired metabolic disease	DOID:0060158	0	0.091
	disease of metabolism	DOID:0014667	0	0.091	Human

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