IMP: Integrative Multi-species Prediction

Drosophila melanogaster

107 known processes

Sema-1a (Dmel_CG18405)

CG18405 gene product from transcript CG18405-RD

(Aliases: BcDNA:RE36155,Fas-IV,d-semaI,sema1a,SemaI,D-Sema-I,CG18405,D-SemaI,FasIV,sema-1a,sema-I,Sema 1a,Sema1A,D-semaI,D-Sema I,D-Sema 1a,CT26404,d-sema I,Sema-I,Dmel\CG18405,Dsema-I,Dsema 1a,sema 1a,Sema1a,sema,l(2)k13702)

FLYBASE: FBgn0011259
Entrez: 34192
UniProtKB: Q24322
UniProtKB: M9MRI2
UniProtKB: M9PB77
UniProtKB: M9PCL7
UniProtKB: Q0E8S4
UniProtKB: M9PFA5

Process Predictions
Disease Predictions

Sema-1a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
axonogenesis	GO:0007409	290	1.000
neuron projection guidance	GO:0097485	241	1.000
axon development	GO:0061564	297	1.000
taxis	GO:0042330	304	1.000
motor neuron axon guidance	GO:0008045	58	1.000
axon guidance	GO:0007411	233	1.000
chemotaxis	GO:0006935	249	1.000
dendrite guidance	GO:0070983	21	0.999	Fly
photoreceptor cell axon guidance	GO:0072499	23	0.993
regulation of cell development	GO:0060284	215	0.978
positive regulation of nervous system development	GO:0051962	69	0.977	Mouse
regulation of photoreceptor cell axon guidance	GO:2000289	5	0.974
regulation of axon extension involved in axon guidance	GO:0048841	4	0.969
dendrite development	GO:0016358	204	0.969
regulation of cell differentiation	GO:0045595	302	0.969
retinal ganglion cell axon guidance	GO:0031290	12	0.967
olfactory bulb axon guidance	GO:0071678	3	0.966	Fly
central nervous system development	GO:0007417	201	0.957
dorsal ventral axon guidance	GO:0033563	2	0.933
regulation of nervous system development	GO:0051960	248	0.918
synapse assembly	GO:0007416	143	0.906
regulation of axon guidance	GO:1902667	10	0.900
dendrite morphogenesis	GO:0048813	199	0.889
regulation of cellular component biogenesis	GO:0044087	201	0.883
positive regulation of cell migration	GO:0030335	2	0.873	Mouse
regulation of multicellular organismal development	GO:2000026	414	0.864
regulation of behavior	GO:0050795	75	0.853
synaptic growth at neuromuscular junction	GO:0051124	119	0.843
axon midline choice point recognition	GO:0016199	26	0.835
positive regulation of axonogenesis	GO:0050772	2	0.827
regulation of neurogenesis	GO:0050767	158	0.815
negative regulation of cell communication	GO:0010648	223	0.809
axon extension involved in axon guidance	GO:0048846	10	0.800
appendage development	GO:0048736	401	0.793
axon target recognition	GO:0007412	16	0.789
regulation of localization	GO:0032879	275	0.783
cell migration	GO:0016477	238	0.756	Mouse
axon choice point recognition	GO:0016198	26	0.742
protein modification process	GO:0036211	438	0.739
positive regulation of transport	GO:0051050	92	0.727
embryonic morphogenesis	GO:0048598	206	0.724
establishment of localization in cell	GO:0051649	402	0.698
positive regulation of response to stimulus	GO:0048584	323	0.690
regulation of neuron differentiation	GO:0045664	103	0.683
organic substance catabolic process	GO:1901575	308	0.682
neuron recognition	GO:0008038	101	0.648
circulatory system development	GO:0072359	82	0.633
axonal defasciculation	GO:0007414	12	0.626
neuromuscular junction development	GO:0007528	149	0.625
stem cell differentiation	GO:0048863	117	0.623
positive regulation of neuron differentiation	GO:0045666	26	0.622
neuron projection extension	GO:1990138	32	0.621
growth	GO:0040007	359	0.618
synapse organization	GO:0050808	196	0.609
regulation of dendrite development	GO:0050773	37	0.604
hindbrain development	GO:0030902	2	0.581
developmental growth	GO:0048589	280	0.577
negative regulation of multicellular organismal process	GO:0051241	142	0.575
regulation of neuron projection development	GO:0010975	69	0.522
cellular protein modification process	GO:0006464	438	0.504
negative regulation of phosphorylation	GO:0042326	35	0.504
negative regulation of response to stimulus	GO:0048585	258	0.503
regulation of axonogenesis	GO:0050770	32	0.498
protein phosphorylation	GO:0006468	169	0.483
regulation of synapse organization	GO:0050807	110	0.473
axon extension	GO:0048675	32	0.470
localization of cell	GO:0051674	257	0.464	Mouse
gastrulation	GO:0007369	70	0.462
head development	GO:0060322	135	0.460
heart development	GO:0007507	82	0.457
regulation of chemotaxis	GO:0050920	12	0.448
regulation of synapse structure and activity	GO:0050803	128	0.445
anterior commissure morphogenesis	GO:0021960	2	0.436
phosphorylation	GO:0016310	294	0.433
regulation of cellular component movement	GO:0051270	42	0.428
muscle structure development	GO:0061061	224	0.428
positive regulation of neurogenesis	GO:0050769	41	0.416	Mouse
regulation of phosphorylation	GO:0042325	147	0.412
regulation of dendrite morphogenesis	GO:0048814	28	0.411
regulation of transport	GO:0051049	181	0.407
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.407
positive regulation of axon guidance	GO:1902669	1	0.399
camera type eye development	GO:0043010	4	0.392
brain development	GO:0007420	120	0.388
regulation of response to external stimulus	GO:0032101	115	0.386
eye morphogenesis	GO:0048592	260	0.368
regulation of developmental growth	GO:0048638	174	0.367
cell death	GO:0008219	279	0.359
gliogenesis	GO:0042063	80	0.351
locomotory behavior	GO:0007626	176	0.348
regulation of phosphorus metabolic process	GO:0051174	210	0.344
cardiovascular system development	GO:0072358	82	0.343
ventral cord development	GO:0007419	16	0.338
regulation of cell motility	GO:2000145	23	0.335	Mouse
sensory organ morphogenesis	GO:0090596	260	0.327
regulation of cellular localization	GO:0060341	136	0.324
positive regulation of cell communication	GO:0010647	250	0.324
stem cell development	GO:0048864	79	0.322
circulatory system process	GO:0003013	37	0.318
regulation of epithelial cell migration open tracheal system	GO:2000274	11	0.318
positive regulation of behavior	GO:0048520	19	0.315
positive regulation of cellular component biogenesis	GO:0044089	80	0.310
forebrain development	GO:0030900	2	0.306
positive regulation of multicellular organismal process	GO:0051240	143	0.304	Mouse
negative regulation of developmental process	GO:0051093	201	0.302
telencephalon development	GO:0021537	2	0.299
cell projection assembly	GO:0030031	94	0.296
synaptic transmission	GO:0007268	288	0.291
mapk cascade	GO:0000165	107	0.288
spinal cord development	GO:0021510	1	0.287
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.284
regulation of cell projection organization	GO:0031344	92	0.284
regulation of molecular function	GO:0065009	217	0.281
regulation of synapse assembly	GO:0051963	94	0.278
positive regulation of cell development	GO:0010720	61	0.276	Mouse
multi multicellular organism process	GO:0044706	123	0.274
cell motility	GO:0048870	251	0.264	Mouse
regulation of vesicle mediated transport	GO:0060627	59	0.263
transcription from rna polymerase ii promoter	GO:0006366	368	0.262
tube development	GO:0035295	244	0.260
regulation of system process	GO:0044057	36	0.257
regulation of growth	GO:0040008	233	0.246
positive regulation of signal transduction	GO:0009967	223	0.243
multi organism behavior	GO:0051705	175	0.236
single organism catabolic process	GO:0044712	228	0.235
regulation of secretion	GO:0051046	44	0.231
epithelial cell development	GO:0002064	274	0.230
gland development	GO:0048732	191	0.229	Fly
filopodium assembly	GO:0046847	33	0.228
positive regulation of developmental process	GO:0051094	143	0.228	Mouse
glial cell differentiation	GO:0010001	35	0.228
regulation of mapk cascade	GO:0043408	92	0.227
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.226
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.225
regulation of anatomical structure size	GO:0090066	163	0.215
morphogenesis of a branching structure	GO:0001763	45	0.215
eye photoreceptor cell differentiation	GO:0001754	145	0.212
positive regulation of transcription dna templated	GO:0045893	266	0.212
positive regulation of secretion	GO:0051047	22	0.209
regulation of synaptic transmission	GO:0050804	69	0.209
negative regulation of phosphorus metabolic process	GO:0010563	45	0.206
positive regulation of cell motility	GO:2000147	3	0.206	Mouse
retrograde axon cargo transport	GO:0008090	9	0.203
cellular macromolecular complex assembly	GO:0034622	153	0.202
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.198
positive regulation of axon extension	GO:0045773	2	0.190
regulation of phosphate metabolic process	GO:0019220	210	0.184
regulation of cell migration	GO:0030334	22	0.182	Mouse
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	26	0.181
photoreceptor cell differentiation	GO:0046530	170	0.179
regulation of neuronal synaptic plasticity	GO:0048168	8	0.178
substrate dependent cell migration	GO:0006929	3	0.178
regulation of protein phosphorylation	GO:0001932	64	0.175
cell maturation	GO:0048469	144	0.174
negative regulation of rna metabolic process	GO:0051253	251	0.170
positive regulation of signaling	GO:0023056	243	0.169
striated muscle cell development	GO:0055002	50	0.168
regulation of cellular response to stress	GO:0080135	89	0.167
negative regulation of synapse assembly	GO:0051964	39	0.164
positive regulation of jun kinase activity	GO:0043507	4	0.162
negative regulation of programmed cell death	GO:0043069	72	0.161
developmental growth involved in morphogenesis	GO:0060560	65	0.158
negative regulation of phosphate metabolic process	GO:0045936	45	0.157
detection of external stimulus	GO:0009581	66	0.157
neuron migration	GO:0001764	5	0.157	Mouse
positive regulation of phosphate metabolic process	GO:0045937	139	0.155
immune system development	GO:0002520	57	0.153
secretion	GO:0046903	109	0.151
positive regulation of synapse assembly	GO:0051965	29	0.151
negative regulation of protein phosphorylation	GO:0001933	17	0.150
developmental maturation	GO:0021700	172	0.147
photoreceptor cell development	GO:0042461	96	0.147
regulation of response to stress	GO:0080134	200	0.145
single organism cellular localization	GO:1902580	180	0.142
multicellular organismal reproductive behavior	GO:0033057	110	0.141
death	GO:0016265	284	0.140
regulation of cell death	GO:0010941	173	0.140
compound eye photoreceptor development	GO:0042051	78	0.138
regulation of immune system process	GO:0002682	176	0.138
regulation of anatomical structure morphogenesis	GO:0022603	242	0.137
adult locomotory behavior	GO:0008344	76	0.137	Fly
negative regulation of gene expression	GO:0010629	387	0.136
positive regulation of response to external stimulus	GO:0032103	44	0.136
digestive system development	GO:0055123	149	0.136
positive regulation of protein complex assembly	GO:0031334	22	0.134
positive regulation of cellular biosynthetic process	GO:0031328	316	0.132
extracellular matrix organization	GO:0030198	32	0.131
positive regulation of rna biosynthetic process	GO:1902680	266	0.131
regulation of intracellular signal transduction	GO:1902531	236	0.131
regulation of ion transport	GO:0043269	39	0.129
negative regulation of cell differentiation	GO:0045596	143	0.128
cell activation	GO:0001775	9	0.128
compound eye photoreceptor cell differentiation	GO:0001751	140	0.127
organonitrogen compound metabolic process	GO:1901564	318	0.127
catabolic process	GO:0009056	409	0.126
single organism intracellular transport	GO:1902582	207	0.125
signal release	GO:0023061	49	0.125
glial cell migration	GO:0008347	31	0.125
signal transduction by phosphorylation	GO:0023014	107	0.124
renal system development	GO:0072001	72	0.123
digestive tract development	GO:0048565	149	0.123
intracellular signal transduction	GO:0035556	300	0.123
regulation of cell proliferation	GO:0042127	163	0.123
vesicle mediated transport	GO:0016192	381	0.122
eye development	GO:0001654	323	0.122
regulation of locomotion	GO:0040012	42	0.121
oxoacid metabolic process	GO:0043436	103	0.121
regulation of catalytic activity	GO:0050790	185	0.120
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.118
dna recombination	GO:0006310	32	0.117
activation of jun kinase activity	GO:0007257	3	0.117
central nervous system projection neuron axonogenesis	GO:0021952	6	0.113
protein localization	GO:0008104	284	0.113
cell junction assembly	GO:0034329	42	0.112
positive regulation of phosphorylation	GO:0042327	87	0.111
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.110
learning or memory	GO:0007611	141	0.110
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.109
positive regulation of biosynthetic process	GO:0009891	316	0.108
erbb signaling pathway	GO:0038127	58	0.108
blood circulation	GO:0008015	26	0.103
establishment of protein localization	GO:0045184	163	0.103
regulation of cytoskeleton organization	GO:0051493	89	0.101
secretion by cell	GO:0032940	101	0.100
positive regulation of neuron projection development	GO:0010976	14	0.099
protein modification by small protein conjugation or removal	GO:0070647	106	0.099
negative regulation of growth	GO:0045926	84	0.099
regulation of programmed cell death	GO:0043067	152	0.098
reproductive behavior	GO:0019098	122	0.097
urogenital system development	GO:0001655	72	0.096
glial cell development	GO:0021782	27	0.096
positive regulation of macromolecule metabolic process	GO:0010604	405	0.096
oocyte differentiation	GO:0009994	145	0.095
regulation of axon extension	GO:0030516	8	0.094
ras protein signal transduction	GO:0007265	88	0.094
morphogenesis of an epithelium	GO:0002009	276	0.093
cellular catabolic process	GO:0044248	372	0.092
eye photoreceptor cell development	GO:0042462	81	0.092
stem cell division	GO:0017145	69	0.092
negative regulation of developmental growth	GO:0048640	64	0.090
embryonic organ development	GO:0048568	50	0.089
regulation of secretion by cell	GO:1903530	39	0.088
membrane organization	GO:0061024	112	0.088
positive regulation of secretion by cell	GO:1903532	20	0.088
positive regulation of phosphorus metabolic process	GO:0010562	139	0.088
response to wounding	GO:0009611	94	0.087
regionalization	GO:0003002	416	0.087
striated muscle cell differentiation	GO:0051146	90	0.086
apoptotic process	GO:0006915	159	0.085
immune response	GO:0006955	246	0.085
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.084
dephosphorylation	GO:0016311	51	0.084
neuron fate commitment	GO:0048663	50	0.083
single organism carbohydrate metabolic process	GO:0044723	72	0.083
organic acid metabolic process	GO:0006082	103	0.081
cellular response to extracellular stimulus	GO:0031668	64	0.080
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.079
negative regulation of cellular metabolic process	GO:0031324	382	0.079
negative regulation of catalytic activity	GO:0043086	42	0.079
tube morphogenesis	GO:0035239	191	0.079
positive regulation of cell differentiation	GO:0045597	64	0.078	Mouse
positive regulation of growth	GO:0045927	75	0.077
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.075
negative regulation of epithelial cell proliferation	GO:0050680	4	0.074
organic substance transport	GO:0071702	257	0.074
r7 cell differentiation	GO:0045466	43	0.074
protein complex biogenesis	GO:0070271	201	0.074
regulation of apoptotic process	GO:0042981	130	0.073
oviposition	GO:0018991	19	0.073
cellular amino acid metabolic process	GO:0006520	61	0.072
single organism membrane organization	GO:0044802	93	0.072
collateral sprouting	GO:0048668	3	0.072
kidney development	GO:0001822	3	0.072
synaptic target recognition	GO:0008039	45	0.071
immune system process	GO:0002376	347	0.071
negative regulation of signaling	GO:0023057	219	0.070
regulation of stress activated mapk cascade	GO:0032872	41	0.070
macromolecule catabolic process	GO:0009057	161	0.070
regulation of protein metabolic process	GO:0051246	256	0.068
regulation of transferase activity	GO:0051338	58	0.068
positive regulation of molecular function	GO:0044093	136	0.068
regulation of map kinase activity	GO:0043405	17	0.068
cell fate specification	GO:0001708	71	0.068
mesenchymal cell development	GO:0014031	1	0.067
muscle cell development	GO:0055001	50	0.067
cell junction organization	GO:0034330	57	0.067
extrinsic apoptotic signaling pathway	GO:0097191	1	0.066
regulation of kinase activity	GO:0043549	53	0.066
imaginal disc derived appendage development	GO:0048737	399	0.064
tor signaling	GO:0031929	32	0.064
programmed cell death	GO:0012501	257	0.064
positive regulation of developmental growth	GO:0048639	62	0.063
negative regulation of axon extension	GO:0030517	3	0.063
positive regulation of exocytosis	GO:0045921	4	0.063
inositol lipid mediated signaling	GO:0048017	4	0.063
macromolecular complex assembly	GO:0065003	256	0.062
protein complex assembly	GO:0006461	200	0.060
regulation of bmp signaling pathway	GO:0030510	23	0.060
regulation of multi organism process	GO:0043900	131	0.060
semaphorin plexin signaling pathway	GO:0071526	4	0.060
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.059
homophilic cell adhesion via plasma membrane adhesion molecules	GO:0007156	18	0.059
stress activated mapk cascade	GO:0051403	52	0.059
cell cell adhesion	GO:0098609	26	0.058
regulation of protein kinase activity	GO:0045859	51	0.058
cell proliferation	GO:0008283	299	0.058
appendage morphogenesis	GO:0035107	397	0.058
intracellular transport	GO:0046907	228	0.058
single organism behavior	GO:0044708	391	0.058	Fly
neuromuscular synaptic transmission	GO:0007274	67	0.058
protein catabolic process	GO:0030163	101	0.057
jnk cascade	GO:0007254	50	0.057
regulation of epithelial cell migration	GO:0010632	12	0.056
regulation of cell size	GO:0008361	63	0.056
stress activated protein kinase signaling cascade	GO:0031098	55	0.056
negative regulation of signal transduction	GO:0009968	206	0.055
neuron death	GO:0070997	27	0.055
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.054
establishment of organelle localization	GO:0051656	122	0.054
central complex development	GO:0048036	9	0.054
mitotic cell cycle phase transition	GO:0044772	138	0.054
cell adhesion	GO:0007155	136	0.053
negative regulation of protein metabolic process	GO:0051248	85	0.053
response to peptide hormone	GO:0043434	29	0.053
central nervous system neuron differentiation	GO:0021953	8	0.052
negative regulation of biosynthetic process	GO:0009890	277	0.051
phenol containing compound metabolic process	GO:0018958	57	0.051
regulation of cellular protein metabolic process	GO:0032268	243	0.051
carboxylic acid metabolic process	GO:0019752	92	0.051
regulation of sequestering of calcium ion	GO:0051282	3	0.051
regulation of protein modification process	GO:0031399	112	0.051
negative regulation of cellular biosynthetic process	GO:0031327	277	0.050
regulation of blood circulation	GO:1903522	21	0.050
developmental cell growth	GO:0048588	52	0.050
epithelial cell migration	GO:0010631	148	0.050
regulation of protein transport	GO:0051223	57	0.050
neuron projection extension involved in neuron projection guidance	GO:1902284	10	0.049
regulation of protein complex assembly	GO:0043254	42	0.049
rho protein signal transduction	GO:0007266	14	0.049
regulation of immune response	GO:0050776	118	0.049
regulation of intracellular transport	GO:0032386	64	0.049
regulation of actin filament based process	GO:0032970	42	0.048
response to abiotic stimulus	GO:0009628	341	0.048	Fly
regulation of r7 cell differentiation	GO:0045676	15	0.048
erk1 and erk2 cascade	GO:0070371	39	0.047
positive regulation of bmp signaling pathway	GO:0030513	5	0.047
protein transport	GO:0015031	155	0.047
cellular macromolecule localization	GO:0070727	220	0.047
meiotic nuclear division	GO:0007126	151	0.047
epithelial cell differentiation	GO:0030855	322	0.047
negative regulation of mapk cascade	GO:0043409	23	0.047
negative regulation of cellular protein metabolic process	GO:0032269	85	0.047
positive regulation of lipid metabolic process	GO:0045834	4	0.046
positive regulation of cellular component organization	GO:0051130	156	0.046
chemical homeostasis	GO:0048878	92	0.046
response to oxygen containing compound	GO:1901700	200	0.046
negative regulation of epithelial cell migration	GO:0010633	1	0.046
negative regulation of neurogenesis	GO:0050768	53	0.046
r7 cell development	GO:0045467	14	0.046
endocytosis	GO:0006897	310	0.045
kidney epithelium development	GO:0072073	3	0.045
small molecule metabolic process	GO:0044281	305	0.045
small gtpase mediated signal transduction	GO:0007264	88	0.045
imaginal disc derived wing morphogenesis	GO:0007476	337	0.045
cellular response to chemical stimulus	GO:0070887	199	0.045
regulation of membrane potential	GO:0042391	35	0.045
regulation of cell growth	GO:0001558	43	0.044
bmp signaling pathway	GO:0030509	27	0.044
cell division	GO:0051301	248	0.044
oocyte axis specification	GO:0007309	108	0.044
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.044
digestive tract morphogenesis	GO:0048546	127	0.043
cell growth	GO:0016049	108	0.043
embryo development ending in birth or egg hatching	GO:0009792	152	0.042	Fly
negative regulation of neuron differentiation	GO:0045665	16	0.042
microtubule based transport	GO:0010970	42	0.042
embryonic development via the syncytial blastoderm	GO:0001700	148	0.041	Fly
oocyte fate determination	GO:0030716	27	0.041
negative regulation of neuromuscular synaptic transmission	GO:1900074	7	0.041
cellular homeostasis	GO:0019725	80	0.041
regulation of neuron apoptotic process	GO:0043523	16	0.040
g protein coupled receptor signaling pathway	GO:0007186	136	0.040
cardiocyte differentiation	GO:0035051	29	0.040
negative regulation of kinase activity	GO:0033673	16	0.040
learning	GO:0007612	75	0.040
muscle organ development	GO:0007517	127	0.040
positive regulation of immune response	GO:0050778	63	0.039
neurological system process	GO:0050877	358	0.039
cellular protein complex disassembly	GO:0043624	35	0.039
regulation of hydrolase activity	GO:0051336	97	0.038
regulation of jnk cascade	GO:0046328	40	0.037
dorsal ventral pattern formation	GO:0009953	133	0.037
regulation of synaptic plasticity	GO:0048167	14	0.037
regulation of production of molecular mediator of immune response	GO:0002700	44	0.037
dorsal ventral axis specification	GO:0009950	66	0.037
response to radiation	GO:0009314	155	0.037	Fly
positive regulation of nucleoside metabolic process	GO:0045979	47	0.037
carbohydrate derivative metabolic process	GO:1901135	217	0.036
peptidyl amino acid modification	GO:0018193	105	0.036
glycoprotein metabolic process	GO:0009100	41	0.036
germ cell migration	GO:0008354	43	0.036
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.035
negative regulation of cellular component organization	GO:0051129	108	0.035
adult chitin containing cuticle pigmentation	GO:0048085	16	0.035
response to alcohol	GO:0097305	95	0.035
peptidyl threonine phosphorylation	GO:0018107	2	0.035
maintenance of presynaptic active zone structure	GO:0048790	8	0.035
positive regulation of catalytic activity	GO:0043085	118	0.034
microtubule based movement	GO:0007018	51	0.034
neuron fate specification	GO:0048665	12	0.034
epithelial cell morphogenesis involved in gastrulation	GO:0003381	7	0.033
cell chemotaxis	GO:0060326	6	0.033
intracellular protein transport	GO:0006886	104	0.033
response to organic substance	GO:0010033	284	0.032
homeostatic process	GO:0042592	199	0.032
hemopoiesis	GO:0030097	46	0.032
regulation of protein secretion	GO:0050708	13	0.032
response to nitrogen compound	GO:1901698	90	0.032
cellular protein complex assembly	GO:0043623	71	0.032
actin filament organization	GO:0007015	126	0.032
amine metabolic process	GO:0009308	12	0.031
metal ion transport	GO:0030001	74	0.031
respiratory system development	GO:0060541	213	0.031
extracellular structure organization	GO:0043062	46	0.031
nephron epithelium development	GO:0072009	3	0.031
adult behavior	GO:0030534	137	0.031	Fly
renal filtration cell differentiation	GO:0061318	12	0.031
epithelial tube morphogenesis	GO:0060562	88	0.031
cytoplasmic transport	GO:0016482	130	0.031
open tracheal system development	GO:0007424	204	0.030
polysaccharide metabolic process	GO:0005976	11	0.030
protein modification by small protein conjugation	GO:0032446	79	0.030
regulation of embryonic pattern specification	GO:1902875	27	0.030
response to organonitrogen compound	GO:0010243	75	0.030
positive regulation of cellular component movement	GO:0051272	11	0.030	Mouse
cognition	GO:0050890	141	0.030
cell recognition	GO:0008037	102	0.029
cell cell junction assembly	GO:0007043	38	0.029
response to endogenous stimulus	GO:0009719	119	0.029
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.029
negative regulation of protein modification process	GO:0031400	29	0.029
axonal fasciculation	GO:0007413	12	0.029
actin polymerization or depolymerization	GO:0008154	31	0.029
positive regulation of rna metabolic process	GO:0051254	271	0.029
positive regulation of cellular amine metabolic process	GO:0033240	0	0.029
oocyte construction	GO:0007308	112	0.029
signal transduction in response to dna damage	GO:0042770	3	0.029
hematopoietic or lymphoid organ development	GO:0048534	57	0.028
endomembrane system organization	GO:0010256	119	0.028
actin filament based process	GO:0030029	220	0.028
negative regulation of molecular function	GO:0044092	51	0.028
response to insulin	GO:0032868	29	0.028
regulation of cellular ketone metabolic process	GO:0010565	3	0.028
organonitrogen compound biosynthetic process	GO:1901566	117	0.028
protein complex disassembly	GO:0043241	36	0.028
regulation of oocyte development	GO:0060281	27	0.027
cellular protein localization	GO:0034613	160	0.027
regulation of organelle organization	GO:0033043	196	0.027
negative regulation of apoptotic process	GO:0043066	63	0.027
determination of bilateral symmetry	GO:0009855	13	0.027
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	9	0.027
neuron remodeling	GO:0016322	29	0.027
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.027
proteolysis	GO:0006508	192	0.027
detection of stimulus	GO:0051606	156	0.027
myotube differentiation	GO:0014902	46	0.027
cellular response to dna damage stimulus	GO:0006974	223	0.027
protein maturation	GO:0051604	71	0.027
negative regulation of transferase activity	GO:0051348	18	0.027
larval development	GO:0002164	104	0.026
negative regulation of cell death	GO:0060548	81	0.026
oocyte development	GO:0048599	124	0.026
protein kinase b signaling	GO:0043491	1	0.026
compound eye morphogenesis	GO:0001745	249	0.026
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.026
phosphatidylinositol mediated signaling	GO:0048015	4	0.026
somatic muscle development	GO:0007525	66	0.026
cytosolic calcium ion transport	GO:0060401	2	0.026
regulation of actin cytoskeleton organization	GO:0032956	42	0.026
regulation of cellular catabolic process	GO:0031329	157	0.025
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.025
actomyosin structure organization	GO:0031032	56	0.025
negative regulation of erbb signaling pathway	GO:1901185	29	0.025
hematopoietic progenitor cell differentiation	GO:0002244	1	0.025
wnt signaling pathway	GO:0016055	98	0.025
carbohydrate metabolic process	GO:0005975	82	0.025
regulation of epithelial cell proliferation	GO:0050678	4	0.025
negative chemotaxis	GO:0050919	15	0.025	Zebrafish Fly
positive regulation of cellular protein metabolic process	GO:0032270	118	0.025
positive regulation of cell projection organization	GO:0031346	29	0.025
nitrogen compound transport	GO:0071705	85	0.025

Sema-1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.303
disease of cellular proliferation	DOID:14566	0.187
cancer	DOID:162	0.187
organ system cancer	DOID:0050686	0.187
nervous system disease	DOID:863	0.096

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