IMP: Integrative Multi-species Prediction

Drosophila melanogaster

29 known processes

aru (Dmel_CG4276)

arouser

(Aliases: CG4276,Dmel\CG4276)

Entrez: 33268
FLYBASE: FBgn0029095
UniProtKB: Q9VPU7
UniProtKB: Q8IPW1

Process Predictions
Disease Predictions

aru biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
olfactory behavior	GO:0042048	97	0.506
organic acid metabolic process	GO:0006082	103	0.315
learning or memory	GO:0007611	141	0.303
establishment of localization in cell	GO:0051649	402	0.267
protein complex assembly	GO:0006461	200	0.237
regulation of phosphate metabolic process	GO:0019220	210	0.228	Human
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.204	Human
phosphorylation	GO:0016310	294	0.201
chemosensory behavior	GO:0007635	106	0.179
single organism behavior	GO:0044708	391	0.177
associative learning	GO:0008306	65	0.162
protein localization	GO:0008104	284	0.133
actin cytoskeleton organization	GO:0030036	206	0.127
intracellular transport	GO:0046907	228	0.121
wing disc morphogenesis	GO:0007472	344	0.117
protein modification process	GO:0036211	438	0.111
neurological system process	GO:0050877	358	0.106
carboxylic acid metabolic process	GO:0019752	92	0.100
protein complex biogenesis	GO:0070271	201	0.097
appendage development	GO:0048736	401	0.094
macromolecular complex assembly	GO:0065003	256	0.092
response to ethanol	GO:0045471	59	0.079
regulation of molecular function	GO:0065009	217	0.077	Human
regulation of phosphorylation	GO:0042325	147	0.072
vesicle mediated transport	GO:0016192	381	0.072
protein ubiquitination	GO:0016567	70	0.070
cognition	GO:0050890	141	0.068
post embryonic appendage morphogenesis	GO:0035120	385	0.067
regulation of localization	GO:0032879	275	0.066
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.065	Human
imaginal disc derived appendage development	GO:0048737	399	0.063
positive regulation of phosphorus metabolic process	GO:0010562	139	0.061	Human
positive regulation of macromolecule metabolic process	GO:0010604	405	0.060
regulation of cellular protein metabolic process	GO:0032268	243	0.059
oxoacid metabolic process	GO:0043436	103	0.059
protein transport	GO:0015031	155	0.059
protein modification by small protein conjugation or removal	GO:0070647	106	0.058
proteolysis	GO:0006508	192	0.056
regulation of transferase activity	GO:0051338	58	0.055
cellular protein modification process	GO:0006464	438	0.054
nucleocytoplasmic transport	GO:0006913	72	0.054
death	GO:0016265	284	0.053
tube development	GO:0035295	244	0.052
digestive tract morphogenesis	GO:0048546	127	0.051
long term memory	GO:0007616	62	0.051
histolysis	GO:0007559	102	0.050
single organism cellular localization	GO:1902580	180	0.049
photoreceptor cell differentiation	GO:0046530	170	0.048
single organism intracellular transport	GO:1902582	207	0.046
regulation of cellular catabolic process	GO:0031329	157	0.046	Human
protein modification by small protein conjugation	GO:0032446	79	0.046
epithelial cell migration	GO:0010631	148	0.046
imaginal disc derived wing morphogenesis	GO:0007476	337	0.045
digestive system development	GO:0055123	149	0.044
appendage morphogenesis	GO:0035107	397	0.044
organic substance transport	GO:0071702	257	0.042
posttranscriptional regulation of gene expression	GO:0010608	145	0.041
regulation of protein metabolic process	GO:0051246	256	0.039
establishment or maintenance of cell polarity	GO:0007163	167	0.037
positive regulation of rna metabolic process	GO:0051254	271	0.037
regulation of cell differentiation	GO:0045595	302	0.037
head development	GO:0060322	135	0.036
regulation of hydrolase activity	GO:0051336	97	0.036	Human
developmental programmed cell death	GO:0010623	138	0.036
cellular macromolecular complex assembly	GO:0034622	153	0.036
cellular macromolecule localization	GO:0070727	220	0.035
protein phosphorylation	GO:0006468	169	0.034
morphogenesis of an epithelium	GO:0002009	276	0.034
endomembrane system organization	GO:0010256	119	0.034
nuclear transport	GO:0051169	72	0.033
establishment of protein localization to organelle	GO:0072594	62	0.033
mitotic spindle elongation	GO:0000022	81	0.032
establishment of protein localization	GO:0045184	163	0.031
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.031
hematopoietic or lymphoid organ development	GO:0048534	57	0.031
regulation of establishment of protein localization	GO:0070201	61	0.031
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.030
regulation of catalytic activity	GO:0050790	185	0.030	Human
negative regulation of phosphorus metabolic process	GO:0010563	45	0.030
tube morphogenesis	GO:0035239	191	0.030
defense response	GO:0006952	300	0.030
nuclear export	GO:0051168	24	0.030
regulation of protein localization	GO:0032880	76	0.030
memory	GO:0007613	94	0.029
positive regulation of catabolic process	GO:0009896	105	0.029	Human
positive regulation of cellular catabolic process	GO:0031331	95	0.029	Human
negative regulation of multicellular organismal process	GO:0051241	142	0.028
immune response	GO:0006955	246	0.027
regulation of multicellular organismal development	GO:2000026	414	0.026
actin filament organization	GO:0007015	126	0.026
regulation of mapk cascade	GO:0043408	92	0.026
developmental growth	GO:0048589	280	0.026
tissue morphogenesis	GO:0048729	297	0.026
protein localization to organelle	GO:0033365	82	0.025
developmental maturation	GO:0021700	172	0.025
organonitrogen compound metabolic process	GO:1901564	318	0.025	Human
ras protein signal transduction	GO:0007265	88	0.025	Human
actin filament based process	GO:0030029	220	0.024
salivary gland cell autophagic cell death	GO:0035071	83	0.024
negative regulation of growth	GO:0045926	84	0.023
lipid metabolic process	GO:0006629	121	0.023
positive regulation of cell communication	GO:0010647	250	0.023
gland morphogenesis	GO:0022612	145	0.023
positive regulation of signal transduction	GO:0009967	223	0.022
small molecule metabolic process	GO:0044281	305	0.022	Human
positive regulation of protein metabolic process	GO:0051247	128	0.021
organelle localization	GO:0051640	148	0.021
regulation of phosphorus metabolic process	GO:0051174	210	0.021	Human
single organism biosynthetic process	GO:0044711	206	0.021
small gtpase mediated signal transduction	GO:0007264	88	0.021	Human
nuclear division	GO:0000280	332	0.020
gtp catabolic process	GO:0006184	72	0.020	Human
regulation of growth	GO:0040008	233	0.020
secretion	GO:0046903	109	0.019
learning	GO:0007612	75	0.019
transcription from rna polymerase ii promoter	GO:0006366	368	0.019
regionalization	GO:0003002	416	0.019
tissue death	GO:0016271	102	0.019
salivary gland histolysis	GO:0035070	88	0.019
spindle elongation	GO:0051231	83	0.019
negative regulation of cellular component organization	GO:0051129	108	0.018
positive regulation of cell death	GO:0010942	69	0.018
ameboidal type cell migration	GO:0001667	151	0.018
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.018
regulation of protein kinase activity	GO:0045859	51	0.018
positive regulation of response to stimulus	GO:0048584	323	0.018
positive regulation of gene expression	GO:0010628	290	0.018
adult behavior	GO:0030534	137	0.018
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.018
membrane organization	GO:0061024	112	0.018
organic substance catabolic process	GO:1901575	308	0.017	Human
mapk cascade	GO:0000165	107	0.017
regulation of ras protein signal transduction	GO:0046578	93	0.017	Human
regulation of cellular component biogenesis	GO:0044087	201	0.017	Human
synapse organization	GO:0050808	196	0.017
negative regulation of kinase activity	GO:0033673	16	0.017
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.017	Human
secretion by cell	GO:0032940	101	0.017
immune system process	GO:0002376	347	0.017
cytoplasmic transport	GO:0016482	130	0.017
muscle structure development	GO:0061061	224	0.017
positive regulation of catalytic activity	GO:0043085	118	0.016	Human
negative regulation of developmental process	GO:0051093	201	0.016
axis specification	GO:0009798	167	0.016
negative regulation of cellular metabolic process	GO:0031324	382	0.016
positive regulation of cellular biosynthetic process	GO:0031328	316	0.016
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.016
regulation of intracellular transport	GO:0032386	64	0.015
regulation of protein modification process	GO:0031399	112	0.015
dendrite morphogenesis	GO:0048813	199	0.015
regulation of protein modification by small protein conjugation or removal	GO:1903320	25	0.015
dna metabolic process	GO:0006259	227	0.015
regulation of cellular component size	GO:0032535	98	0.015
negative regulation of mitotic cell cycle	GO:0045930	109	0.015
jak stat cascade	GO:0007259	49	0.015
response to organic cyclic compound	GO:0014070	89	0.014
response to alcohol	GO:0097305	95	0.014
brain development	GO:0007420	120	0.014
single organism membrane organization	GO:0044802	93	0.014
regulation of cellular amine metabolic process	GO:0033238	3	0.014
mitotic cell cycle phase transition	GO:0044772	138	0.014
anatomical structure homeostasis	GO:0060249	97	0.014
negative regulation of gene expression	GO:0010629	387	0.014
regulation of cell cycle	GO:0051726	291	0.014
regulation of kinase activity	GO:0043549	53	0.014
positive regulation of signaling	GO:0023056	243	0.014
regulation of catabolic process	GO:0009894	170	0.014	Human
response to other organism	GO:0051707	293	0.014
regulation of developmental growth	GO:0048638	174	0.014
cytoplasmic translation	GO:0002181	0	0.014
negative regulation of nervous system development	GO:0051961	92	0.014
cellular response to chemical stimulus	GO:0070887	199	0.014
digestive tract development	GO:0048565	149	0.014
regulation of intracellular signal transduction	GO:1902531	236	0.013	Human
cell migration	GO:0016477	238	0.013
epithelium migration	GO:0090132	148	0.013
homeostatic process	GO:0042592	199	0.013
cell death	GO:0008219	279	0.013
phagocytosis	GO:0006909	215	0.012
autophagic cell death	GO:0048102	83	0.012
embryonic development via the syncytial blastoderm	GO:0001700	148	0.012
photoreceptor cell development	GO:0042461	96	0.012
regulation of protein transport	GO:0051223	57	0.012
positive regulation of intracellular signal transduction	GO:1902533	116	0.012
wnt signaling pathway	GO:0016055	98	0.012
microtubule organizing center organization	GO:0031023	168	0.012
molting cycle	GO:0042303	56	0.012
negative regulation of response to stimulus	GO:0048585	258	0.012
single organism cell adhesion	GO:0098602	47	0.012
cellular protein localization	GO:0034613	160	0.011
response to external biotic stimulus	GO:0043207	293	0.011
regulation of nucleocytoplasmic transport	GO:0046822	35	0.011
protein dna complex subunit organization	GO:0071824	86	0.011
endocytosis	GO:0006897	310	0.011
positive regulation of gtpase activity	GO:0043547	43	0.011	Human
sensory organ morphogenesis	GO:0090596	260	0.011
apoptotic process	GO:0006915	159	0.011
protein secretion	GO:0009306	45	0.011
salivary gland development	GO:0007431	162	0.011
olfactory learning	GO:0008355	56	0.011
cellular response to organic substance	GO:0071310	132	0.011
translation	GO:0006412	69	0.010
compound eye photoreceptor cell differentiation	GO:0001751	140	0.010
neuromuscular process	GO:0050905	21	0.010
regulation of cellular amino acid metabolic process	GO:0006521	0	0.010
anterior posterior axis specification	GO:0009948	109	0.010
protein import	GO:0017038	55	0.010
male gamete generation	GO:0048232	201	0.010

aru disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.016

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