IMP: Integrative Multi-species Prediction

Drosophila melanogaster

74 known processes

NT1 (Dmel_CG42576)

Neurotrophin 1

(Aliases: CG42576,DNT1,CG18318,CG32242,Dmel_CG32244,Dmel_CG32242,CG32244,CT30097,Spz2,Dmel\CG42576,spz2)

Entrez: 38558
FLYBASE: FBgn0261526
UniProtKB: Q8IRB0
UniProtKB: B7TB45
UniProtKB: Q9VZA9

Process Predictions
Disease Predictions

NT1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
motor neuron axon guidance	GO:0008045	58	0.976
taxis	GO:0042330	304	0.781
axonogenesis	GO:0007409	290	0.774
axon development	GO:0061564	297	0.609
neuron projection guidance	GO:0097485	241	0.503
central nervous system development	GO:0007417	201	0.492
chemotaxis	GO:0006935	249	0.473
axon guidance	GO:0007411	233	0.450
dendrite morphogenesis	GO:0048813	199	0.286
positive regulation of cell communication	GO:0010647	250	0.244
regulation of response to stress	GO:0080134	200	0.243
regulation of nervous system development	GO:0051960	248	0.226
death	GO:0016265	284	0.215
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.213
dendrite development	GO:0016358	204	0.207
programmed cell death	GO:0012501	257	0.172
gliogenesis	GO:0042063	80	0.145
positive regulation of macromolecule metabolic process	GO:0010604	405	0.144
apoptotic process	GO:0006915	159	0.138
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.133
regulation of cellular catabolic process	GO:0031329	157	0.128
regulation of multicellular organismal development	GO:2000026	414	0.122
positive regulation of signal transduction	GO:0009967	223	0.121
imaginal disc derived appendage development	GO:0048737	399	0.110
regulation of response to external stimulus	GO:0032101	115	0.110
anatomical structure homeostasis	GO:0060249	97	0.109
negative regulation of multicellular organismal process	GO:0051241	142	0.108
regulation of neurogenesis	GO:0050767	158	0.106
response to nitrogen compound	GO:1901698	90	0.094
establishment of localization in cell	GO:0051649	402	0.094
cell death	GO:0008219	279	0.093
neuron recognition	GO:0008038	101	0.093
phosphorylation	GO:0016310	294	0.092
eye antennal disc development	GO:0035214	60	0.091
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.088
regulation of transport	GO:0051049	181	0.086
cellular response to dna damage stimulus	GO:0006974	223	0.084
positive regulation of response to stimulus	GO:0048584	323	0.079
antennal development	GO:0007469	25	0.077
negative regulation of developmental process	GO:0051093	201	0.077
regulation of dendrite morphogenesis	GO:0048814	28	0.076
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.075
regulation of cellular response to stress	GO:0080135	89	0.073
transcription from rna polymerase ii promoter	GO:0006366	368	0.072
regulation of autophagy	GO:0010506	62	0.071
apoptotic signaling pathway	GO:0097190	27	0.071
response to oxygen containing compound	GO:1901700	200	0.070
negative regulation of nervous system development	GO:0051961	92	0.069
immune response regulating signaling pathway	GO:0002764	2	0.068
positive regulation of cellular biosynthetic process	GO:0031328	316	0.067
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.066
regulation of growth	GO:0040008	233	0.066
response to abiotic stimulus	GO:0009628	341	0.063
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.063
response to organic substance	GO:0010033	284	0.062
regulation of cell shape	GO:0008360	113	0.060
negative regulation of neurogenesis	GO:0050768	53	0.059
positive regulation of catabolic process	GO:0009896	105	0.059
positive regulation of autophagy	GO:0010508	21	0.059
brain development	GO:0007420	120	0.058
imaginal disc derived leg morphogenesis	GO:0007480	80	0.058
lateral inhibition	GO:0046331	206	0.058
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.058
positive regulation of cellular catabolic process	GO:0031331	95	0.057
autophagy	GO:0006914	108	0.057
single organism catabolic process	GO:0044712	228	0.057
determination of adult lifespan	GO:0008340	137	0.057
regulation of catabolic process	GO:0009894	170	0.057
positive regulation of signaling	GO:0023056	243	0.056
compound eye photoreceptor cell differentiation	GO:0001751	140	0.056
cell recognition	GO:0008037	102	0.055
regulation of intracellular signal transduction	GO:1902531	236	0.054
activation of innate immune response	GO:0002218	4	0.054
forebrain development	GO:0030900	2	0.054
telencephalon development	GO:0021537	2	0.053
regulation of axon extension involved in axon guidance	GO:0048841	4	0.052
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.052
positive regulation of transcription dna templated	GO:0045893	266	0.051
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.051
regulation of axonogenesis	GO:0050770	32	0.050
regulation of protein metabolic process	GO:0051246	256	0.050
developmental programmed cell death	GO:0010623	138	0.050
immune response activating signal transduction	GO:0002757	2	0.048
negative regulation of cellular metabolic process	GO:0031324	382	0.048
cell proliferation	GO:0008283	299	0.047
response to external biotic stimulus	GO:0043207	293	0.047
signal transduction by phosphorylation	GO:0023014	107	0.047
regulation of cell development	GO:0060284	215	0.047
positive regulation of gene expression	GO:0010628	290	0.046
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.046
regulation of catalytic activity	GO:0050790	185	0.045
positive regulation of transport	GO:0051050	92	0.045
regulation of chemotaxis	GO:0050920	12	0.045
regulation of cell morphogenesis	GO:0022604	163	0.044
intracellular transport	GO:0046907	228	0.044
regulation of cell death	GO:0010941	173	0.044
antennal morphogenesis	GO:0048800	14	0.044
negative regulation of developmental growth	GO:0048640	64	0.044
regulation of phosphorus metabolic process	GO:0051174	210	0.043
response to endogenous stimulus	GO:0009719	119	0.043
eye morphogenesis	GO:0048592	260	0.043
protein modification process	GO:0036211	438	0.043
regulation of localization	GO:0032879	275	0.042
positive regulation of hydrolase activity	GO:0051345	78	0.042
positive regulation of rna metabolic process	GO:0051254	271	0.041
regulation of molecular function	GO:0065009	217	0.041
intracellular signal transduction	GO:0035556	300	0.040
defense response	GO:0006952	300	0.039
multicellular organismal aging	GO:0010259	140	0.039
embryo development ending in birth or egg hatching	GO:0009792	152	0.039
cell migration	GO:0016477	238	0.039
post embryonic appendage morphogenesis	GO:0035120	385	0.039
regulation of anatomical structure morphogenesis	GO:0022603	242	0.038
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.038
positive regulation of rna biosynthetic process	GO:1902680	266	0.038
regulation of programmed cell death	GO:0043067	152	0.037
small molecule metabolic process	GO:0044281	305	0.037
regulation of protein transport	GO:0051223	57	0.036
cellular response to external stimulus	GO:0071496	66	0.036
glial cell differentiation	GO:0010001	35	0.036
response to organic cyclic compound	GO:0014070	89	0.035
negative regulation of biosynthetic process	GO:0009890	277	0.035
appendage morphogenesis	GO:0035107	397	0.035
regulation of immune response	GO:0050776	118	0.035
positive regulation of protein metabolic process	GO:0051247	128	0.035
regulation of cell cycle	GO:0051726	291	0.034
synaptic transmission	GO:0007268	288	0.034
response to radiation	GO:0009314	155	0.034
positive regulation of molecular function	GO:0044093	136	0.033
extrinsic apoptotic signaling pathway	GO:0097191	1	0.033
pattern recognition receptor signaling pathway	GO:0002221	2	0.033
eye development	GO:0001654	323	0.033
regulation of response to dna damage stimulus	GO:2001020	23	0.033
cellular protein modification process	GO:0006464	438	0.032
negative regulation of cell death	GO:0060548	81	0.032
regulation of mapk cascade	GO:0043408	92	0.032
negative regulation of response to stimulus	GO:0048585	258	0.032
regulation of neuron projection development	GO:0010975	69	0.031
nucleoside phosphate metabolic process	GO:0006753	162	0.031
regulation of cellular localization	GO:0060341	136	0.031
photoreceptor cell axon guidance	GO:0072499	23	0.031
regulation of cell size	GO:0008361	63	0.031
organonitrogen compound metabolic process	GO:1901564	318	0.030
compound eye development	GO:0048749	307	0.030
positive regulation of developmental process	GO:0051094	143	0.030
regulation of developmental growth	GO:0048638	174	0.030
proteolysis	GO:0006508	192	0.030
single organism behavior	GO:0044708	391	0.030
integrin mediated signaling pathway	GO:0007229	3	0.029
regulation of neuron differentiation	GO:0045664	103	0.029
positive regulation of multicellular organismal process	GO:0051240	143	0.029
neuron fate commitment	GO:0048663	50	0.029
gland morphogenesis	GO:0022612	145	0.029
positive regulation of phosphate metabolic process	GO:0045937	139	0.028
positive regulation of biosynthetic process	GO:0009891	316	0.028
cellular catabolic process	GO:0044248	372	0.028
organic substance catabolic process	GO:1901575	308	0.028
catabolic process	GO:0009056	409	0.027
nucleobase containing small molecule metabolic process	GO:0055086	174	0.027
tissue migration	GO:0090130	155	0.027
regulation of endopeptidase activity	GO:0052548	36	0.027
cellular response to chemical stimulus	GO:0070887	199	0.026
mapk cascade	GO:0000165	107	0.026
positive regulation of peptidase activity	GO:0010952	29	0.026
exocrine system development	GO:0035272	162	0.025
head development	GO:0060322	135	0.025
regulation of establishment of protein localization	GO:0070201	61	0.025
biological adhesion	GO:0022610	138	0.025
regulation of rho protein signal transduction	GO:0035023	20	0.024
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.024
regulation of axon guidance	GO:1902667	10	0.024
negative regulation of cell size	GO:0045792	19	0.024
regulation of ras protein signal transduction	GO:0046578	93	0.024
regulation of intracellular transport	GO:0032386	64	0.024
regulation of cellular protein metabolic process	GO:0032268	243	0.024
positive regulation of endopeptidase activity	GO:0010950	26	0.024
protein phosphorylation	GO:0006468	169	0.023
multicellular organismal reproductive behavior	GO:0033057	110	0.023
negative regulation of programmed cell death	GO:0043069	72	0.023
regulation of synaptic transmission	GO:0050804	69	0.023
immune response	GO:0006955	246	0.023
positive regulation of nervous system development	GO:0051962	69	0.023
innate immune response activating signal transduction	GO:0002758	2	0.023
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.023
segmentation	GO:0035282	207	0.023
ras protein signal transduction	GO:0007265	88	0.022
defense response to other organism	GO:0098542	225	0.022
cell adhesion	GO:0007155	136	0.022
positive regulation of protein transport	GO:0051222	37	0.022
appendage development	GO:0048736	401	0.022
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.022
single organism intracellular transport	GO:1902582	207	0.021
actin cytoskeleton organization	GO:0030036	206	0.021
establishment of planar polarity	GO:0001736	87	0.021
positive regulation of cell motility	GO:2000147	3	0.021
positive regulation of catalytic activity	GO:0043085	118	0.021
negative regulation of growth	GO:0045926	84	0.021
response to ionizing radiation	GO:0010212	32	0.020
sensory organ morphogenesis	GO:0090596	260	0.020
nucleoside metabolic process	GO:0009116	127	0.020
regulation of multicellular organism growth	GO:0040014	40	0.020
epithelium migration	GO:0090132	148	0.020
positive regulation of phosphorylation	GO:0042327	87	0.020
negative regulation of cellular biosynthetic process	GO:0031327	277	0.020
homeostatic process	GO:0042592	199	0.020
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.020
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.020
positive regulation of apoptotic process	GO:0043065	47	0.020
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.020
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.020
positive regulation of cell migration	GO:0030335	2	0.020
regulation of synaptic plasticity	GO:0048167	14	0.020
guanosine containing compound metabolic process	GO:1901068	74	0.020
positive regulation of proteolysis	GO:0045862	52	0.019
stress activated mapk cascade	GO:0051403	52	0.019
nuclear transport	GO:0051169	72	0.019
negative regulation of apoptotic process	GO:0043066	63	0.019
epithelial structure maintenance	GO:0010669	17	0.019
axonal defasciculation	GO:0007414	12	0.019
positive regulation of phosphorus metabolic process	GO:0010562	139	0.019
protein processing	GO:0016485	68	0.018
regulation of response to wounding	GO:1903034	19	0.018
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.018
glycosyl compound metabolic process	GO:1901657	127	0.018
eye photoreceptor cell fate commitment	GO:0042706	37	0.018
regulation of protein localization	GO:0032880	76	0.018
regulation of defense response	GO:0031347	102	0.018
regulation of cellular component size	GO:0032535	98	0.018
nucleoside phosphate catabolic process	GO:1901292	110	0.018
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.018
purine nucleoside catabolic process	GO:0006152	112	0.017
single organism cellular localization	GO:1902580	180	0.017
regulation of phosphorylation	GO:0042325	147	0.017
regulation of multi organism process	GO:0043900	131	0.017
ribonucleoside metabolic process	GO:0009119	127	0.017
development of primary sexual characteristics	GO:0045137	50	0.017
male gamete generation	GO:0048232	201	0.017
cellular response to organic substance	GO:0071310	132	0.017
larval development	GO:0002164	104	0.017
eye photoreceptor cell differentiation	GO:0001754	145	0.017
nitrogen compound transport	GO:0071705	85	0.016
organic substance transport	GO:0071702	257	0.016
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.016
cell fate specification	GO:0001708	71	0.016
eye antennal disc morphogenesis	GO:0007455	34	0.016
regulation of cellular ketone metabolic process	GO:0010565	3	0.016
negative regulation of cellular protein metabolic process	GO:0032269	85	0.016
positive regulation of intracellular signal transduction	GO:1902533	116	0.016
mitochondrion organization	GO:0007005	65	0.016
purine nucleotide metabolic process	GO:0006163	146	0.016
establishment of protein localization	GO:0045184	163	0.016
axon target recognition	GO:0007412	16	0.015
ribonucleotide catabolic process	GO:0009261	109	0.015
cytoplasmic transport	GO:0016482	130	0.015
dna metabolic process	GO:0006259	227	0.015
ribose phosphate metabolic process	GO:0019693	145	0.015
positive regulation of neurogenesis	GO:0050769	41	0.015
regulation of hydrolase activity	GO:0051336	97	0.015
protein modification by small protein conjugation	GO:0032446	79	0.015
regulation of defense response to virus	GO:0050688	14	0.015
defense response to virus	GO:0051607	23	0.015
nucleoside catabolic process	GO:0009164	112	0.015
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.015
chaeta development	GO:0022416	97	0.015
purine nucleoside metabolic process	GO:0042278	127	0.015
aging	GO:0007568	143	0.015
purine nucleotide catabolic process	GO:0006195	109	0.015
negative regulation of cell development	GO:0010721	62	0.015
ribonucleotide metabolic process	GO:0009259	145	0.014
nucleoside triphosphate metabolic process	GO:0009141	120	0.014
protein transport	GO:0015031	155	0.014
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.014
negative regulation of axon extension	GO:0030517	3	0.014
cellular response to oxygen containing compound	GO:1901701	79	0.014
cell division	GO:0051301	248	0.014
cation transport	GO:0006812	110	0.014
nucleotide metabolic process	GO:0009117	161	0.014
positive regulation of cellular amine metabolic process	GO:0033240	0	0.014
epithelial cell differentiation	GO:0030855	322	0.014
response to organophosphorus	GO:0046683	2	0.014
positive regulation of growth	GO:0045927	75	0.014
glycosyl compound catabolic process	GO:1901658	112	0.013
response to organonitrogen compound	GO:0010243	75	0.013
regulation of cellular amine metabolic process	GO:0033238	3	0.013
salivary gland development	GO:0007431	162	0.013
localization of cell	GO:0051674	257	0.013
compound eye photoreceptor fate commitment	GO:0001752	36	0.013
regulation of response to biotic stimulus	GO:0002831	63	0.013
immune effector process	GO:0002252	98	0.013
negative regulation of cell differentiation	GO:0045596	143	0.013
photoreceptor cell differentiation	GO:0046530	170	0.013
positive regulation of mapk cascade	GO:0043410	63	0.013
regulation of peptidase activity	GO:0052547	39	0.013
camera type eye development	GO:0043010	4	0.013
response to starvation	GO:0042594	97	0.013
amine metabolic process	GO:0009308	12	0.013
spinal cord development	GO:0021510	1	0.013
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.013
g protein coupled receptor signaling pathway	GO:0007186	136	0.012
regulation of nucleocytoplasmic transport	GO:0046822	35	0.012
cellular homeostasis	GO:0019725	80	0.012
regulation of cell projection organization	GO:0031344	92	0.012
regulation of dendrite development	GO:0050773	37	0.012
peripheral nervous system development	GO:0007422	52	0.012
gtp catabolic process	GO:0006184	72	0.012
synaptic target recognition	GO:0008039	45	0.012
carboxylic acid metabolic process	GO:0019752	92	0.012
embryonic development via the syncytial blastoderm	GO:0001700	148	0.012
neuron fate specification	GO:0048665	12	0.012
reproductive system development	GO:0061458	74	0.012
leg disc morphogenesis	GO:0007478	80	0.012
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.012
negative regulation of rna metabolic process	GO:0051253	251	0.012
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.012
regulation of phosphate metabolic process	GO:0019220	210	0.012
small gtpase mediated signal transduction	GO:0007264	88	0.012
cellular response to endogenous stimulus	GO:0071495	80	0.012
stress activated protein kinase signaling cascade	GO:0031098	55	0.012
positive regulation of cell death	GO:0010942	69	0.012
response to biotic stimulus	GO:0009607	294	0.012
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.012
positive regulation of cell differentiation	GO:0045597	64	0.012
organic cyclic compound catabolic process	GO:1901361	168	0.011
purine ribonucleotide catabolic process	GO:0009154	109	0.011
regulation of mitotic cell cycle	GO:0007346	190	0.011
rho protein signal transduction	GO:0007266	14	0.011
heterocycle catabolic process	GO:0046700	166	0.011
organophosphate metabolic process	GO:0019637	195	0.011
innate immune response	GO:0045087	144	0.011
purine containing compound catabolic process	GO:0072523	112	0.011
purine ribonucleoside catabolic process	GO:0046130	112	0.011
regulation of vesicle mediated transport	GO:0060627	59	0.011
regulation of cell differentiation	GO:0045595	302	0.011
circulatory system development	GO:0072359	82	0.011
positive regulation of immune system process	GO:0002684	68	0.011
germ band extension	GO:0007377	11	0.011
gland development	GO:0048732	191	0.011
organonitrogen compound catabolic process	GO:1901565	128	0.011
erbb signaling pathway	GO:0038127	58	0.011
positive regulation of programmed cell death	GO:0043068	62	0.011
single organism cell adhesion	GO:0098602	47	0.011
regulation of apoptotic process	GO:0042981	130	0.011
mesenchymal cell development	GO:0014031	1	0.011
mesenchymal cell differentiation	GO:0048762	1	0.011
positive regulation of intracellular transport	GO:0032388	42	0.010
carbohydrate derivative catabolic process	GO:1901136	118	0.010
regionalization	GO:0003002	416	0.010
ribonucleoside catabolic process	GO:0042454	112	0.010
muscle structure development	GO:0061061	224	0.010
developmental growth	GO:0048589	280	0.010
cell fate determination	GO:0001709	91	0.010
nucleotide catabolic process	GO:0009166	109	0.010
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.010
positive regulation of notch signaling pathway	GO:0045747	34	0.010
regulation of immune system process	GO:0002682	176	0.010
positive regulation of immune response	GO:0050778	63	0.010
photoreceptor cell fate commitment	GO:0046552	41	0.010
protein complex localization	GO:0031503	4	0.010

NT1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.018

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