Drosophila melanogaster

48 known processes

MCPH1 (Dmel_CG42572)

Microcephalin

(Aliases: mcph1,CG13184,CG42572,awol,CG8981,CG30038,Dmel_CG8981,Dmel_CG30038,Dmel\CG42572,Dmcph1)

MCPH1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
female meiotic divisionGO:0007143700.467
mitotic cell cycle phase transitionGO:00447721380.339
organelle fissionGO:00482853400.337
negative regulation of g2 m transition of mitotic cell cycleGO:001097280.276
nuclear divisionGO:00002803320.244
dna metabolic processGO:00062592270.222
regulation of organelle organizationGO:00330431960.210
regulation of cell cycleGO:00517262910.209
regulation of protein metabolic processGO:00512462560.192
cell maturationGO:00484691440.188
cell deathGO:00082192790.176
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.173
negative regulation of cellular biosynthetic processGO:00313272770.167
single fertilizationGO:0007338240.156
embryo development ending in birth or egg hatchingGO:00097921520.147
deathGO:00162652840.145
protein localizationGO:00081042840.142
regulation of mitotic cell cycleGO:00073461900.141
regulation of cell cycle processGO:00105641810.138
regulation of cellular protein metabolic processGO:00322682430.131
growthGO:00400073590.129
regulation of mitosisGO:0007088560.123
regulation of cell cycle phase transitionGO:19019871300.120
organelle localizationGO:00516401480.119
chromosome organizationGO:00512763600.118
cell motilityGO:00488702510.114
negative regulation of cellular metabolic processGO:00313243820.113
establishment of organelle localizationGO:00516561220.111
g2 m transition of mitotic cell cycleGO:0000086190.109
localization of cellGO:00516742570.106
negative regulation of biosynthetic processGO:00098902770.104
negative regulation of cell cycle processGO:00109481090.103
cellular protein modification processGO:00064644380.102
response to radiationGO:00093141550.102
developmental growthGO:00485892800.099
response to abiotic stimulusGO:00096283410.098
negative regulation of nucleobase containing compound metabolic processGO:00459342610.097
cellular response to dna damage stimulusGO:00069742230.094
chromosome segregationGO:00070591570.092
central nervous system developmentGO:00074172010.091
oocyte developmentGO:00485991240.089
cell cycle phase transitionGO:00447701400.089
oocyte differentiationGO:00099941450.087
developmental maturationGO:00217001720.086
establishment of cell polarityGO:0030010400.084
regulation of mitotic cell cycle phase transitionGO:19019901300.081
negative regulation of macromolecule biosynthetic processGO:00105582700.079
regulation of oocyte developmentGO:0060281270.077
macromolecular complex assemblyGO:00650032560.075
fertilizationGO:0009566260.075
cell divisionGO:00513012480.072
regulation of cellular component biogenesisGO:00440872010.071
negative regulation of cell cycleGO:00457861160.071
cellularizationGO:0007349900.071
programmed cell deathGO:00125012570.070
regulation of localizationGO:00328792750.064
oocyte constructionGO:00073081120.061
rho protein signal transductionGO:0007266140.060
transcription from rna polymerase ii promoterGO:00063663680.059
protein complex biogenesisGO:00702712010.059
regulation of multicellular organismal developmentGO:20000264140.059
double strand break repair via nonhomologous end joiningGO:000630350.058
negative regulation of mitotic cell cycleGO:00459301090.058
response to organic substanceGO:00100332840.056
cellular catabolic processGO:00442483720.054
developmental programmed cell deathGO:00106231380.054
cell migrationGO:00164772380.054
sister chromatid segregationGO:0000819920.053
negative regulation of gene expressionGO:00106293870.052
response to uvGO:0009411240.052
response to oxygen containing compoundGO:19017002000.050
nucleus organizationGO:0006997450.050
small gtpase mediated signal transductionGO:0007264880.050
cellular macromolecule localizationGO:00707272200.049
positive regulation of cellular protein metabolic processGO:00322701180.049
determination of adult lifespanGO:00083401370.048
appendage morphogenesisGO:00351073970.047
regulation of nuclear divisionGO:0051783580.047
enzyme linked receptor protein signaling pathwayGO:00071671790.047
taxisGO:00423303040.047
negative regulation of cell cycle phase transitionGO:19019881030.045
regulation of transcription from rna polymerase ii promoterGO:00063573780.045
histone mrna metabolic processGO:000833480.045
ubiquitin dependent protein catabolic processGO:0006511780.045
protein modification processGO:00362114380.045
organelle assemblyGO:00709251980.044
regulation of cell divisionGO:0051302720.044
cellular protein localizationGO:00346131600.043
regulation of pole plasm oskar mrna localizationGO:0007317270.043
catabolic processGO:00090564090.042
negative regulation of response to stimulusGO:00485852580.042
positive regulation of response to stimulusGO:00485843230.042
actin filament based processGO:00300292200.042
mitotic sister chromatid segregationGO:0000070870.041
male pronucleus assemblyGO:003503960.041
germ cell migrationGO:0008354430.041
dna conformation changeGO:00711031050.040
regulation of catabolic processGO:00098941700.040
negative regulation of nitrogen compound metabolic processGO:00511722650.040
chemotaxisGO:00069352490.040
response to light stimulusGO:00094161240.039
negative regulation of signal transductionGO:00099682060.039
regulation of embryonic pattern specificationGO:1902875270.039
dna repairGO:0006281540.039
male gamete generationGO:00482322010.039
anterior posterior pattern specificationGO:00099521360.038
regulation of catalytic activityGO:00507901850.038
maternal determination of anterior posterior axis embryoGO:0008358740.038
regulation of chromosome segregationGO:0051983320.038
chromatin organizationGO:00063252070.038
neuron projection guidanceGO:00974852410.038
organic substance catabolic processGO:19015753080.037
digestive tract developmentGO:00485651490.037
embryonic morphogenesisGO:00485982060.037
tube morphogenesisGO:00352391910.037
regulation of cell developmentGO:00602842150.037
nuclear importGO:0051170510.037
regulation of small gtpase mediated signal transductionGO:0051056930.036
regulation of chromosome organizationGO:0033044640.036
meiotic nuclear divisionGO:00071261510.036
vesicle mediated transportGO:00161923810.036
ribonucleoside triphosphate catabolic processGO:00092031080.036
purine ribonucleotide catabolic processGO:00091541090.035
regulation of cell maturationGO:1903429270.035
spermatogenesisGO:00072832000.035
regulation of cytoskeleton organizationGO:0051493890.035
positive regulation of macromolecule metabolic processGO:00106044050.034
negative regulation of transcription dna templatedGO:00458922370.034
small molecule metabolic processGO:00442813050.034
establishment of localization in cellGO:00516494020.034
actin mediated cell contractionGO:0070252210.034
pole cell developmentGO:0007277260.033
maintenance of locationGO:0051235730.033
pole cell formationGO:0007279190.033
axis specificationGO:00097981670.033
rna processingGO:00063961470.033
ribonucleoside triphosphate metabolic processGO:00091991190.032
stem cell proliferationGO:0072089880.032
nucleotide metabolic processGO:00091171610.032
regulation of dna metabolic processGO:0051052340.032
anterior posterior axis specificationGO:00099481090.032
positive regulation of catabolic processGO:00098961050.032
positive regulation of purine nucleotide catabolic processGO:0033123460.031
single organism cellular localizationGO:19025801800.031
response to ionizing radiationGO:0010212320.031
positive regulation of hydrolase activityGO:0051345780.031
appendage developmentGO:00487364010.030
body morphogenesisGO:001017120.030
actin cytoskeleton organizationGO:00300362060.030
positive regulation of cellular component organizationGO:00511301560.030
axon developmentGO:00615642970.029
nucleoside phosphate catabolic processGO:19012921100.029
intracellular signal transductionGO:00355563000.029
tube developmentGO:00352952440.029
ribose phosphate metabolic processGO:00196931450.029
regulation of molecular functionGO:00650092170.029
regulation of ras protein signal transductionGO:0046578930.029
mrna metabolic processGO:00160711240.029
cellular response to organic substanceGO:00713101320.029
ribonucleotide metabolic processGO:00092591450.029
establishment of nucleus localizationGO:0040023260.029
cellular nitrogen compound catabolic processGO:00442701650.028
positive regulation of developmental processGO:00510941430.028
dna packagingGO:0006323910.028
regulation of g2 m transition of mitotic cell cycleGO:0010389150.028
gastrulationGO:0007369700.028
sensory organ morphogenesisGO:00905962600.028
purine nucleoside triphosphate catabolic processGO:00091461080.027
axon guidanceGO:00074112330.027
organophosphate catabolic processGO:00464341120.026
regulation of programmed cell deathGO:00430671520.026
nucleus localizationGO:0051647340.026
compound eye morphogenesisGO:00017452490.026
response to woundingGO:0009611940.026
positive regulation of cellular catabolic processGO:0031331950.026
pole plasm assemblyGO:0007315610.026
kidney developmentGO:000182230.026
actin filament based movementGO:0030048260.026
oocyte axis specificationGO:00073091080.026
cellular component assembly involved in morphogenesisGO:00109271510.025
negative regulation of nucleic acid templated transcriptionGO:19035072400.025
cytoplasm organizationGO:0007028640.025
positive regulation of gtpase activityGO:0043547430.025
phagocytosisGO:00069092150.025
reproductive structure developmentGO:0048608740.025
positive regulation of multicellular organismal processGO:00512401430.024
dna dependent dna replicationGO:0006261170.024
imaginal disc derived appendage developmentGO:00487373990.024
compound eye developmentGO:00487493070.024
regulation of cell proliferationGO:00421271630.024
regulation of cell differentiationGO:00455953020.024
protein modification by small protein conjugation or removalGO:00706471060.024
negative regulation of protein metabolic processGO:0051248850.023
meiotic cell cycleGO:00513211710.023
regulation of cellular localizationGO:00603411360.023
proteolysisGO:00065081920.023
regulation of protein modification processGO:00313991120.023
purine ribonucleoside triphosphate metabolic processGO:00092051190.023
head developmentGO:00603221350.023
reproductive system developmentGO:0061458740.023
positive regulation of organelle organizationGO:0010638650.023
nucleoside triphosphate catabolic processGO:00091431080.022
embryonic pattern specificationGO:00098801740.022
positive regulation of ras gtpase activityGO:0032320360.022
mitotic nuclear divisionGO:00070672130.022
multicellular organismal agingGO:00102591400.022
embryonic development via the syncytial blastodermGO:00017001480.022
purine ribonucleotide metabolic processGO:00091501450.022
nucleoside metabolic processGO:00091161270.022
non recombinational repairGO:000072670.022
brain developmentGO:00074201200.022
purine nucleotide catabolic processGO:00061951090.022
chromatin assembly or disassemblyGO:0006333520.022
negative regulation of mitotic cell cycle phase transitionGO:19019911030.021
positive regulation of cellular component biogenesisGO:0044089800.021
post embryonic appendage morphogenesisGO:00351203850.021
cellular protein complex assemblyGO:0043623710.021
ribonucleoside catabolic processGO:00424541120.021
ribonucleoside metabolic processGO:00091191270.021
purine ribonucleoside triphosphate catabolic processGO:00092071080.021
negative regulation of signalingGO:00230572190.021
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.021
protein catabolic processGO:00301631010.021
atp dependent chromatin remodelingGO:0043044220.021
cell cycle g2 m phase transitionGO:0044839220.020
regulation of protein catabolic processGO:0042176550.020
gland morphogenesisGO:00226121450.020
regulation of embryonic developmentGO:0045995680.020
nucleotide catabolic processGO:00091661090.020
organophosphate metabolic processGO:00196371950.020
negative regulation of cell cycle g2 m phase transitionGO:190275080.019
compound eye photoreceptor cell differentiationGO:00017511400.019
positive regulation of catalytic activityGO:00430851180.019
wing disc morphogenesisGO:00074723440.019
mitotic g2 m transition checkpointGO:0044818700.019
purine nucleotide metabolic processGO:00061631460.019
negative regulation of rna biosynthetic processGO:19026792400.019
positive regulation of molecular functionGO:00440931360.019
embryonic axis specificationGO:00005781070.019
regulation of cellular catabolic processGO:00313291570.019
oocyte anterior posterior axis specificationGO:0007314720.018
aromatic compound catabolic processGO:00194391660.018
chromosome separationGO:0051304420.018
cellular response to chemical stimulusGO:00708871990.018
purine ribonucleoside metabolic processGO:00461281270.018
dna replicationGO:0006260480.018
centrosome organizationGO:00512971630.018
metaphase anaphase transition of cell cycleGO:0044784280.018
nucleobase containing small molecule metabolic processGO:00550861740.018
negative regulation of developmental processGO:00510932010.018
pole plasm mrna localizationGO:0019094490.018
positive regulation of nucleobase containing compound metabolic processGO:00459353320.018
epithelial cell developmentGO:00020642740.018
pole plasm rna localizationGO:0007316520.018
macromolecule catabolic processGO:00090571610.017
carbohydrate derivative metabolic processGO:19011352170.017
mitotic sister chromatid separationGO:0051306300.017
nucleoside phosphate metabolic processGO:00067531620.017
nucleoside catabolic processGO:00091641120.017
homeostatic processGO:00425921990.017
regulation of cell sizeGO:0008361630.017
retina development in camera type eyeGO:006004140.017
protein complex assemblyGO:00064612000.017
regulation of protein localizationGO:0032880760.017
blastoderm segmentationGO:00073501590.017
pole plasm protein localizationGO:0007318100.017
positive regulation of protein metabolic processGO:00512471280.017
positive regulation of transcription dna templatedGO:00458932660.016
regionalizationGO:00030024160.016
carbohydrate derivative catabolic processGO:19011361180.016
cellular macromolecular complex assemblyGO:00346221530.016
regulation of reproductive processGO:2000241540.016
glycosyl compound metabolic processGO:19016571270.016
single organism biosynthetic processGO:00447112060.016
positive regulation of purine nucleotide metabolic processGO:1900544550.016
wnt signaling pathwayGO:0016055980.016
regulation of sister chromatid segregationGO:0033045280.016
purine nucleoside triphosphate metabolic processGO:00091441190.016
meiotic cell cycle processGO:19030461320.016
regulation of mitotic metaphase anaphase transitionGO:0030071260.015
positive regulation of rna metabolic processGO:00512542710.015
positive regulation of cellular amino acid metabolic processGO:004576400.015
positive regulation of nucleic acid templated transcriptionGO:19035082660.015
sex differentiationGO:0007548810.015
circulatory system developmentGO:0072359820.015
eye morphogenesisGO:00485922600.015
regulation of actin filament based processGO:0032970420.015
pole plasm oskar mrna localizationGO:0045451460.015
cuticle developmentGO:0042335860.015
spindle assemblyGO:0051225800.015
nephron developmentGO:007200630.015
single organism catabolic processGO:00447122280.015
protein transportGO:00150311550.015
regulation of actin cytoskeleton organizationGO:0032956420.015
chromatin modificationGO:00165681470.015
regulation of intracellular signal transductionGO:19025312360.015
regulation of cellular ketone metabolic processGO:001056530.015
negative regulation of translationGO:0017148280.015
ribonucleotide catabolic processGO:00092611090.015
intracellular protein transportGO:00068861040.015
regulation of proteolysisGO:0030162870.015
tripartite regional subdivisionGO:00073511030.015
positive regulation of growthGO:0045927750.014
positive regulation of phosphate metabolic processGO:00459371390.014
regulation of transportGO:00510491810.014
glycosyl compound catabolic processGO:19016581120.014
chromatin remodelingGO:0006338720.014
histone modificationGO:00165701060.014
regulation of transferase activityGO:0051338580.014
male meiosis cytokinesisGO:0007112260.014
eye photoreceptor cell differentiationGO:00017541450.014
mrna processingGO:00063971040.014
axonogenesisGO:00074092900.014
organonitrogen compound metabolic processGO:19015643180.014
positive regulation of rna biosynthetic processGO:19026802660.014
positive regulation of cell motilityGO:200014730.014
negative regulation of rna metabolic processGO:00512532510.014
establishment of protein localizationGO:00451841630.014
pronuclear fusionGO:000734440.014
agingGO:00075681430.014
oocyte microtubule cytoskeleton organizationGO:0016325350.013
camera type eye morphogenesisGO:004859320.013
gtp catabolic processGO:0006184720.013
regulation of phosphate metabolic processGO:00192202100.013
regulation of translationGO:0006417560.013
maintenance of protein location in cellGO:0032507260.013
eye developmentGO:00016543230.013
forebrain developmentGO:003090020.013
open tracheal system developmentGO:00074242040.013
protein phosphorylationGO:00064681690.013
nuclear migrationGO:0007097200.013
regulation of metaphase anaphase transition of cell cycleGO:1902099260.013
nephron epithelium developmentGO:007200930.013
negative regulation of cell communicationGO:00106482230.013
protein polymerizationGO:0051258420.013
ribonucleoside monophosphate catabolic processGO:0009158390.013
cuticle pattern formationGO:0035017270.013
purine nucleoside catabolic processGO:00061521120.013
regulation of epithelial cell differentiationGO:003085640.013
cellular protein catabolic processGO:0044257830.013
positive regulation of phosphorus metabolic processGO:00105621390.013
microtubule organizing center organizationGO:00310231680.013
organic acid metabolic processGO:00060821030.013
regulation of cellular protein catabolic processGO:1903362440.013
mitotic cell cycle embryonicGO:0045448380.012
positive regulation of proteolysisGO:0045862520.012
imaginal disc derived wing morphogenesisGO:00074763370.012
positive regulation of gene expressionGO:00106282900.012
covalent chromatin modificationGO:00165691060.012
karyogamyGO:000074140.012
regulation of cellular amino acid metabolic processGO:000652100.012
purine containing compound catabolic processGO:00725231120.012
cilium morphogenesisGO:0060271390.012
positive regulation of cell communicationGO:00106472500.012
positive regulation of signalingGO:00230562430.012
peptidyl amino acid modificationGO:00181931050.012
apoptotic processGO:00069151590.012
mrna 3 end processingGO:0031124280.012
negative regulation of synapse assemblyGO:0051964390.012
protein targetingGO:0006605640.012
regulation of cellular component sizeGO:0032535980.012
carboxylic acid metabolic processGO:0019752920.012
anterior posterior axis specification embryoGO:00085951030.012
cellular macromolecule catabolic processGO:00442651360.012
endocytosisGO:00068973100.012
microtubule polymerization or depolymerizationGO:0031109390.012
notch signaling pathwayGO:00072191200.012
organic cyclic compound catabolic processGO:19013611680.012
gonad developmentGO:0008406500.012
negative regulation of cell differentiationGO:00455961430.012
ras protein signal transductionGO:0007265880.011
response to organic cyclic compoundGO:0014070890.011
regulation of proteasomal protein catabolic processGO:0061136390.011
positive regulation of transportGO:0051050920.011
modification dependent macromolecule catabolic processGO:0043632790.011
cellular amino acid metabolic processGO:0006520610.011
positive regulation of developmental growthGO:0048639620.011
cell proliferationGO:00082832990.011
photoreceptor cell differentiationGO:00465301700.011
regulation of response to stressGO:00801342000.011
intracellular mrna localization involved in anterior posterior axis specificationGO:0060811530.011
maintenance of location in cellGO:0051651280.011
positive regulation of nitrogen compound metabolic processGO:00511733540.011
actin filament organizationGO:00070151260.011
cellular response to abiotic stimulusGO:0071214580.011
establishment or maintenance of cytoskeleton polarityGO:0030952440.011
regulation of apoptotic processGO:00429811300.011
regulation of cellular response to stressGO:0080135890.011
centrosome duplicationGO:00512981210.011
negative regulation of cell developmentGO:0010721620.011
negative regulation of nervous system developmentGO:0051961920.011
regulation of establishment of protein localizationGO:0070201610.011
positive regulation of phosphorylationGO:0042327870.011
kidney epithelium developmentGO:007207330.011
gtp metabolic processGO:0046039720.011
positive regulation of cytoskeleton organizationGO:0051495210.011
hindbrain developmentGO:003090220.010
cellular ketone metabolic processGO:0042180240.010
protein deubiquitinationGO:0016579170.010
gland developmentGO:00487321910.010
positive regulation of signal transductionGO:00099672230.010
regulation of nervous system developmentGO:00519602480.010
telencephalon developmentGO:002153720.010
histolysisGO:00075591020.010
development of primary sexual characteristicsGO:0045137500.010
kidney morphogenesisGO:006099330.010
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101180.010
heterocycle catabolic processGO:00467001660.010
spindle organizationGO:00070512530.010

MCPH1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.027
organ system cancerDOID:005068600.027
disease of cellular proliferationDOID:1456600.027
disease of anatomical entityDOID:700.014