IMP: Integrative Multi-species Prediction

Drosophila melanogaster

130 known processes

Nipped-A (Dmel_CG33554)

CG33554 gene product from transcript CG33554-RE

(Aliases: l(2)C123,Tra-1,l(2)EMS34-12,l(2)41Ah,Nipped[A],NipA,tra1,Dmel\CG33554,GroupV,Tra1,CG33554,Nip-A,dTRRAP,TRRAP,dTra1,CG2905,dmTRRAP,CG10549,41Ah)

FLYBASE: FBgn0053554
Entrez: 35483
UniProtKB: Q8I8U7
UniProtKB: Q2EZ47

Process Predictions
Disease Predictions

Nipped-A biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
chromosome organization	GO:0051276	360	0.867
dna templated transcription initiation	GO:0006352	25	0.769
chromatin organization	GO:0006325	207	0.750
nuclear division	GO:0000280	332	0.685
regulation of neurogenesis	GO:0050767	158	0.681
organelle fission	GO:0048285	340	0.676
cellular response to dna damage stimulus	GO:0006974	223	0.625	Yeast
embryo development ending in birth or egg hatching	GO:0009792	152	0.603	Worm
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.597
positive regulation of rna metabolic process	GO:0051254	271	0.574	Yeast
histone acetylation	GO:0016573	38	0.569
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.538	Yeast
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.523	Yeast
meiotic nuclear division	GO:0007126	151	0.517
protein acetylation	GO:0006473	39	0.502
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.460	Yeast
histone h4 acetylation	GO:0043967	13	0.454	Human
developmental growth	GO:0048589	280	0.438
transcription from rna polymerase ii promoter	GO:0006366	368	0.430	Yeast
regulation of organelle organization	GO:0033043	196	0.430
protein acylation	GO:0043543	42	0.427
axonogenesis	GO:0007409	290	0.390
transcription initiation from rna polymerase ii promoter	GO:0006367	25	0.363
positive regulation of rna biosynthetic process	GO:1902680	266	0.357	Yeast
positive regulation of transcription dna templated	GO:0045893	266	0.324	Yeast
axon development	GO:0061564	297	0.312
gene silencing by mirna	GO:0035195	22	0.311
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.308	Yeast
body morphogenesis	GO:0010171	2	0.301	Worm
innate immune response	GO:0045087	144	0.294
g2 dna damage checkpoint	GO:0031572	69	0.285
defense response	GO:0006952	300	0.271
regulation of dendrite development	GO:0050773	37	0.263
dendrite development	GO:0016358	204	0.260
single organism intracellular transport	GO:1902582	207	0.255
mitotic g2 m transition checkpoint	GO:0044818	70	0.249
neuron projection guidance	GO:0097485	241	0.245
reproductive system development	GO:0061458	74	0.245	Worm
eye development	GO:0001654	323	0.240
pigment metabolic process	GO:0042440	84	0.234
modification dependent macromolecule catabolic process	GO:0043632	79	0.222
positive regulation of cellular biosynthetic process	GO:0031328	316	0.213	Yeast
regulation of mitotic cell cycle	GO:0007346	190	0.207	Mouse
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.205	Yeast
histone modification	GO:0016570	106	0.203
imaginal disc derived wing vein specification	GO:0007474	48	0.195
pigment metabolic process involved in developmental pigmentation	GO:0043324	33	0.195
cellular catabolic process	GO:0044248	372	0.194
meiotic cell cycle process	GO:1903046	132	0.191
negative regulation of cell cycle process	GO:0010948	109	0.178	Mouse
salivary gland morphogenesis	GO:0007435	145	0.177
regulation of nervous system development	GO:0051960	248	0.169
regulation of multicellular organismal development	GO:2000026	414	0.167	Worm
mitotic nuclear division	GO:0007067	213	0.165
response to abiotic stimulus	GO:0009628	341	0.163
regulation of cellular component biogenesis	GO:0044087	201	0.162
regulation of neuron differentiation	GO:0045664	103	0.159
compound eye photoreceptor cell differentiation	GO:0001751	140	0.158
histone h3 acetylation	GO:0043966	11	0.158
nucleosome mobilization	GO:0042766	9	0.154
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.152	Mouse
peptidyl lysine acetylation	GO:0018394	39	0.152
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	20	0.143
mitotic dna damage checkpoint	GO:0044773	74	0.142
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.142	Yeast
protein complex biogenesis	GO:0070271	201	0.142
melanin metabolic process	GO:0006582	47	0.137
cell cycle phase transition	GO:0044770	140	0.137	Mouse
dendrite morphogenesis	GO:0048813	199	0.137
chromatin assembly	GO:0031497	48	0.133
cellular protein catabolic process	GO:0044257	83	0.131
immune response	GO:0006955	246	0.130
cellular macromolecule catabolic process	GO:0044265	136	0.130
eye pigment metabolic process	GO:0042441	33	0.127
development of primary sexual characteristics	GO:0045137	50	0.127	Worm
negative regulation of neurogenesis	GO:0050768	53	0.124
regulation of neuron projection development	GO:0010975	69	0.122
establishment or maintenance of cell polarity	GO:0007163	167	0.121
apoptotic process	GO:0006915	159	0.120
protein modification process	GO:0036211	438	0.120
peptidyl lysine modification	GO:0018205	57	0.116
histone h4 k16 acetylation	GO:0043984	4	0.112
regulation of intracellular signal transduction	GO:1902531	236	0.108
mitotic g2 dna damage checkpoint	GO:0007095	69	0.106
regulation of phosphate metabolic process	GO:0019220	210	0.105
regulation of molecular function	GO:0065009	217	0.103
taxis	GO:0042330	304	0.103
regulation of developmental growth	GO:0048638	174	0.102
protein dna complex subunit organization	GO:0071824	86	0.102
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.100	Mouse
meiotic cell cycle	GO:0051321	171	0.099
macromolecular complex assembly	GO:0065003	256	0.099
growth	GO:0040007	359	0.098	Worm
covalent chromatin modification	GO:0016569	106	0.096
mitotic dna integrity checkpoint	GO:0044774	75	0.096
negative regulation of cellular biosynthetic process	GO:0031327	277	0.094
proteasomal protein catabolic process	GO:0010498	59	0.093
developmental maturation	GO:0021700	172	0.091
internal protein amino acid acetylation	GO:0006475	38	0.090
pigment metabolic process involved in pigmentation	GO:0043474	33	0.090
positive regulation of gene expression	GO:0010628	290	0.089	Yeast
positive regulation of response to stimulus	GO:0048584	323	0.089
dna integrity checkpoint	GO:0031570	81	0.089
catabolic process	GO:0009056	409	0.088
chromatin remodeling	GO:0006338	72	0.088
gliogenesis	GO:0042063	80	0.088
dna metabolic process	GO:0006259	227	0.087	Yeast
establishment of organelle localization	GO:0051656	122	0.086
intracellular transport	GO:0046907	228	0.085
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.085
regulation of chromosome organization	GO:0033044	64	0.084
melanotic encapsulation of foreign target	GO:0035011	30	0.083
regulation of mitosis	GO:0007088	56	0.081
regulation of cell division	GO:0051302	72	0.081
mitotic cytokinesis	GO:0000281	50	0.080
immune system process	GO:0002376	347	0.080
phosphorylation	GO:0016310	294	0.079
negative regulation of cell cycle	GO:0045786	116	0.078	Mouse
chromatin modification	GO:0016568	147	0.078
ribose phosphate metabolic process	GO:0019693	145	0.078
positive regulation of signal transduction	GO:0009967	223	0.077
sex differentiation	GO:0007548	81	0.076	Worm
axis specification	GO:0009798	167	0.075
photoreceptor cell differentiation	GO:0046530	170	0.075
positive regulation of signaling	GO:0023056	243	0.075
ommochrome biosynthetic process	GO:0006727	19	0.074
appendage development	GO:0048736	401	0.073
dna damage checkpoint	GO:0000077	78	0.072
cellular protein modification process	GO:0006464	438	0.072
organic substance transport	GO:0071702	257	0.070
regulation of apoptotic process	GO:0042981	130	0.069
establishment of protein localization	GO:0045184	163	0.068
positive regulation of phosphate metabolic process	GO:0045937	139	0.068
positive regulation of cell communication	GO:0010647	250	0.067
intracellular signal transduction	GO:0035556	300	0.065
regulation of cell cycle process	GO:0010564	181	0.065	Mouse
death	GO:0016265	284	0.063
nucleotide catabolic process	GO:0009166	109	0.062
single organism cellular localization	GO:1902580	180	0.062
single organism catabolic process	GO:0044712	228	0.061
macromolecule catabolic process	GO:0009057	161	0.061
salivary gland development	GO:0007431	162	0.058
regulation of cell death	GO:0010941	173	0.058
regulation of cell development	GO:0060284	215	0.057
cell death	GO:0008219	279	0.055
mitotic cell cycle checkpoint	GO:0007093	88	0.054	Mouse
muscle cell development	GO:0055001	50	0.053
embryonic development via the syncytial blastoderm	GO:0001700	148	0.053
male gamete generation	GO:0048232	201	0.052
protein complex assembly	GO:0006461	200	0.052
positive regulation of transcription factor import into nucleus	GO:0042993	19	0.051
positive regulation of catabolic process	GO:0009896	105	0.051
negative regulation of mitotic cell cycle	GO:0045930	109	0.050	Mouse
positive regulation of notch signaling pathway	GO:0045747	34	0.050
negative regulation of cell cycle phase transition	GO:1901988	103	0.050	Mouse
ras protein signal transduction	GO:0007265	88	0.050
intracellular receptor signaling pathway	GO:0030522	19	0.050
gland morphogenesis	GO:0022612	145	0.049
positive regulation of neurogenesis	GO:0050769	41	0.049
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.049
chromatin assembly or disassembly	GO:0006333	52	0.048
heterocycle catabolic process	GO:0046700	166	0.047
secondary metabolic process	GO:0019748	75	0.047
purine ribonucleotide metabolic process	GO:0009150	145	0.047
actin filament based process	GO:0030029	220	0.047
developmental pigmentation	GO:0048066	68	0.046
meiotic chromosome segregation	GO:0045132	59	0.046
regulation of cell projection organization	GO:0031344	92	0.046
chromosome segregation	GO:0007059	157	0.045
phenol containing compound metabolic process	GO:0018958	57	0.045
vesicle mediated transport	GO:0016192	381	0.045
glycosyl compound catabolic process	GO:1901658	112	0.044
positive regulation of macromolecule metabolic process	GO:0010604	405	0.044	Yeast
gene silencing	GO:0016458	138	0.044
dna templated transcriptional preinitiation complex assembly	GO:0070897	20	0.043
regulation of ras protein signal transduction	GO:0046578	93	0.043
posttranscriptional gene silencing by rna	GO:0035194	45	0.043
golgi to plasma membrane transport	GO:0006893	8	0.043
larval development	GO:0002164	104	0.043	Worm
defense response to other organism	GO:0098542	225	0.042
internal peptidyl lysine acetylation	GO:0018393	38	0.042
carboxylic acid metabolic process	GO:0019752	92	0.042
encapsulation of foreign target	GO:0035010	38	0.042
negative regulation of rna biosynthetic process	GO:1902679	240	0.041
small gtpase mediated signal transduction	GO:0007264	88	0.040
glial cell migration	GO:0008347	31	0.040
stem cell differentiation	GO:0048863	117	0.040
cellular component assembly involved in morphogenesis	GO:0010927	151	0.040
central nervous system development	GO:0007417	201	0.040
programmed cell death	GO:0012501	257	0.039
positive regulation of r7 cell differentiation	GO:0045678	7	0.039
axon guidance	GO:0007411	233	0.039
negative regulation of cellular metabolic process	GO:0031324	382	0.038
histone h2a acetylation	GO:0043968	1	0.038	Human
negative regulation of developmental process	GO:0051093	201	0.038	Worm
sensory organ morphogenesis	GO:0090596	260	0.038
nucleobase containing compound catabolic process	GO:0034655	165	0.037
gene silencing by rna	GO:0031047	57	0.037
pronuclear migration	GO:0035046	4	0.037
microtubule organizing center organization	GO:0031023	168	0.036
cellular protein complex assembly	GO:0043623	71	0.036
oocyte axis specification	GO:0007309	108	0.036
digestive system development	GO:0055123	149	0.035
meiosis i	GO:0007127	59	0.035
rrna processing	GO:0006364	3	0.035
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.035
nuclear transport	GO:0051169	72	0.034
imaginal disc derived appendage development	GO:0048737	399	0.034
positive regulation of molecular function	GO:0044093	136	0.034
telomere capping	GO:0016233	11	0.034
negative regulation of cell differentiation	GO:0045596	143	0.034
actin cytoskeleton organization	GO:0030036	206	0.033
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.033
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.033
spindle organization	GO:0007051	253	0.033
protein targeting	GO:0006605	64	0.033
regulation of synapse structure and activity	GO:0050803	128	0.033
hemocyte differentiation	GO:0042386	38	0.033
positive regulation of biosynthetic process	GO:0009891	316	0.033	Yeast
metaphase anaphase transition of cell cycle	GO:0044784	28	0.033
protein catabolic process	GO:0030163	101	0.033
exocrine system development	GO:0035272	162	0.033
compound eye morphogenesis	GO:0001745	249	0.032
positive regulation of transport	GO:0051050	92	0.032
cuticle development	GO:0042335	86	0.032
cell projection assembly	GO:0030031	94	0.032
regulation of meiosis	GO:0040020	3	0.031
positive regulation of intracellular signal transduction	GO:1902533	116	0.031
response to organic cyclic compound	GO:0014070	89	0.031
notch signaling pathway	GO:0007219	120	0.031
genitalia development	GO:0048806	26	0.031	Worm
autophagy	GO:0006914	108	0.031
negative regulation of signaling	GO:0023057	219	0.030
ocellus pigment metabolic process	GO:0046158	19	0.030
eye photoreceptor cell differentiation	GO:0001754	145	0.030
negative regulation of biosynthetic process	GO:0009890	277	0.030
compound eye development	GO:0048749	307	0.030
gonad development	GO:0008406	50	0.029	Worm
cell growth	GO:0016049	108	0.029
regulation of cell differentiation	GO:0045595	302	0.029
regulation of cell morphogenesis	GO:0022604	163	0.029
regulation of cell cycle phase transition	GO:1901987	130	0.028	Mouse
response to endogenous stimulus	GO:0009719	119	0.028
regulation of cell proliferation	GO:0042127	163	0.028
striated muscle myosin thick filament assembly	GO:0071688	3	0.028
negative regulation of programmed cell death	GO:0043069	72	0.028
regulation of catabolic process	GO:0009894	170	0.028
nephron epithelium morphogenesis	GO:0072088	3	0.028
regulation of glial cell proliferation	GO:0060251	11	0.028
reproductive structure development	GO:0048608	74	0.028	Worm
ion transport	GO:0006811	145	0.028
negative regulation of neuroblast proliferation	GO:0007406	27	0.027
organelle localization	GO:0051640	148	0.027
atp dependent chromatin remodeling	GO:0043044	22	0.027
cellular ketone metabolic process	GO:0042180	24	0.027
regionalization	GO:0003002	416	0.027
cytoplasmic transport	GO:0016482	130	0.027
negative regulation of gene expression	GO:0010629	387	0.027
defense response to bacterium	GO:0042742	178	0.026
positive regulation of metaphase anaphase transition of cell cycle	GO:1902101	10	0.026
establishment of protein localization to organelle	GO:0072594	62	0.026
cell proliferation	GO:0008283	299	0.026
positive regulation of cellular component organization	GO:0051130	156	0.026
mitotic sister chromatid separation	GO:0051306	30	0.026
dna repair	GO:0006281	54	0.026	Yeast
jak stat cascade	GO:0007259	49	0.025
neuron projection extension	GO:1990138	32	0.025
regulation of programmed cell death	GO:0043067	152	0.025
positive regulation of cell cycle	GO:0045787	43	0.025
regulation of chromatin organization	GO:1902275	32	0.025
epidermal cell differentiation	GO:0009913	51	0.025
histone h2a ubiquitination	GO:0033522	2	0.025
oocyte construction	GO:0007308	112	0.025
regulation of gene expression epigenetic	GO:0040029	128	0.025
dendrite guidance	GO:0070983	21	0.024
regulation of nuclear division	GO:0051783	58	0.024
negative regulation of apoptotic process	GO:0043066	63	0.024
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.024
nephron tubule morphogenesis	GO:0072078	3	0.024
positive regulation of phosphorylation	GO:0042327	87	0.023
nucleosome positioning	GO:0016584	3	0.023
nucleoside metabolic process	GO:0009116	127	0.023
organic hydroxy compound metabolic process	GO:1901615	83	0.023
regulation of protein complex assembly	GO:0043254	42	0.023
proteolysis	GO:0006508	192	0.023
axon extension	GO:0048675	32	0.023
protein targeting to nucleus	GO:0044744	51	0.022
nucleocytoplasmic transport	GO:0006913	72	0.022
plasma membrane organization	GO:0007009	26	0.022
brain development	GO:0007420	120	0.022
aromatic compound catabolic process	GO:0019439	166	0.022
purine nucleotide metabolic process	GO:0006163	146	0.022
neuroblast proliferation	GO:0007405	74	0.022
protein localization to organelle	GO:0033365	82	0.022
positive regulation of phosphorus metabolic process	GO:0010562	139	0.022
establishment of planar polarity	GO:0001736	87	0.021
regulation of phosphorus metabolic process	GO:0051174	210	0.021
regulation of purine nucleotide catabolic process	GO:0033121	48	0.021
posttranscriptional regulation of gene expression	GO:0010608	145	0.021
nucleus localization	GO:0051647	34	0.021
mrna catabolic process	GO:0006402	33	0.021
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.021
nitrogen compound transport	GO:0071705	85	0.021
nephron morphogenesis	GO:0072028	3	0.021
positive regulation of gtp catabolic process	GO:0033126	43	0.021
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.021
organelle assembly	GO:0070925	198	0.021
glial cell differentiation	GO:0010001	35	0.021
nuclear transcribed mrna catabolic process	GO:0000956	24	0.021
posttranscriptional gene silencing	GO:0016441	46	0.021
small molecule metabolic process	GO:0044281	305	0.020
positive regulation of immune response	GO:0050778	63	0.020
dorsal closure	GO:0007391	79	0.020
mrna splice site selection	GO:0006376	1	0.020
amine metabolic process	GO:0009308	12	0.020
response to heat	GO:0009408	63	0.020
response to organic substance	GO:0010033	284	0.020
branching morphogenesis of an epithelial tube	GO:0048754	45	0.020
cell division	GO:0051301	248	0.019
cellular response to organic substance	GO:0071310	132	0.019
dna conformation change	GO:0071103	105	0.019
regulation of growth	GO:0040008	233	0.019	Worm
negative regulation of rna metabolic process	GO:0051253	251	0.019
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.019
synapse organization	GO:0050808	196	0.019
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.019
response to temperature stimulus	GO:0009266	106	0.019
regulation of cellular ketone metabolic process	GO:0010565	3	0.019
mitotic cell cycle phase transition	GO:0044772	138	0.019	Mouse
eye photoreceptor cell development	GO:0042462	81	0.019
post embryonic appendage morphogenesis	GO:0035120	385	0.019
establishment of spindle orientation	GO:0051294	18	0.019
positive regulation of proteolysis	GO:0045862	52	0.019
chitin based cuticle development	GO:0040003	49	0.018
positive regulation of defense response	GO:0031349	59	0.018
pigmentation	GO:0043473	75	0.018
carbohydrate metabolic process	GO:0005975	82	0.018
regulation of phosphorylation	GO:0042325	147	0.018
intracellular protein transport	GO:0006886	104	0.018
sensory organ precursor cell division	GO:0045035	10	0.018
neuron recognition	GO:0008038	101	0.018
ubiquitin dependent protein catabolic process	GO:0006511	78	0.018
regulation of cell growth	GO:0001558	43	0.018
digestive tract development	GO:0048565	149	0.018
regulation of cellular response to stress	GO:0080135	89	0.018
regulation of cell cycle	GO:0051726	291	0.018	Mouse
purine nucleoside catabolic process	GO:0006152	112	0.018
mitotic spindle organization	GO:0007052	220	0.017
regulation of protein modification process	GO:0031399	112	0.017
negative regulation of cell communication	GO:0010648	223	0.017
organic acid metabolic process	GO:0006082	103	0.017
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.017
response to wounding	GO:0009611	94	0.017
positive regulation of mitotic cell cycle phase transition	GO:1901992	20	0.017
organic substance catabolic process	GO:1901575	308	0.017
purine containing compound metabolic process	GO:0072521	155	0.017
ribonucleotide catabolic process	GO:0009261	109	0.017
modification dependent protein catabolic process	GO:0019941	78	0.017
myofibril assembly	GO:0030239	36	0.017
cellular response to chemical stimulus	GO:0070887	199	0.016
telencephalon development	GO:0021537	2	0.016
stem cell development	GO:0048864	79	0.016
histone h3 k9 acetylation	GO:0043970	3	0.016
oxoacid metabolic process	GO:0043436	103	0.016
muscle structure development	GO:0061061	224	0.016
nuclear import	GO:0051170	51	0.016
positive regulation of organelle organization	GO:0010638	65	0.016
positive regulation of histone acetylation	GO:0035066	3	0.016
synaptic growth at neuromuscular junction	GO:0051124	119	0.016
regulation of compound eye cone cell fate specification	GO:0042682	4	0.016
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.016
digestive tract morphogenesis	GO:0048546	127	0.016
positive regulation of cellular protein catabolic process	GO:1903364	24	0.016
spermatid development	GO:0007286	98	0.016
nephron tubule development	GO:0072080	3	0.015
branch fusion open tracheal system	GO:0035147	17	0.015
forebrain development	GO:0030900	2	0.015
mitotic sister chromatid segregation	GO:0000070	87	0.015
regulation of cellular catabolic process	GO:0031329	157	0.015
cell maturation	GO:0048469	144	0.015
rhythmic process	GO:0048511	106	0.015
protein phosphorylation	GO:0006468	169	0.015
single organism nuclear import	GO:1902593	51	0.015
protein transport	GO:0015031	155	0.015
response to external biotic stimulus	GO:0043207	293	0.015
female meiosis chromosome segregation	GO:0016321	33	0.015
cellular response to nutrient levels	GO:0031669	62	0.014
regulation of protein catabolic process	GO:0042176	55	0.014
antennal development	GO:0007469	25	0.014
regulation of proteasomal protein catabolic process	GO:0061136	39	0.014
positive regulation of glial cell proliferation	GO:0060252	5	0.014
positive regulation of mitotic sister chromatid separation	GO:1901970	10	0.014
positive regulation of protein complex assembly	GO:0031334	22	0.014
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.014
ribonucleoside metabolic process	GO:0009119	127	0.014
dorsal trunk growth open tracheal system	GO:0035001	7	0.014
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.014
cellular nitrogen compound catabolic process	GO:0044270	165	0.014
establishment of ommatidial planar polarity	GO:0042067	49	0.014
protein modification by small protein conjugation or removal	GO:0070647	106	0.014	Human
regulation of purine nucleotide metabolic process	GO:1900542	62	0.013
chromatin mediated maintenance of transcription	GO:0048096	7	0.013
dna packaging	GO:0006323	91	0.013
negative regulation of nervous system development	GO:0051961	92	0.013
negative regulation of cellular component organization	GO:0051129	108	0.013
centrosome organization	GO:0051297	163	0.013
postreplication repair	GO:0006301	2	0.013
response to bacterium	GO:0009617	198	0.013
response to extracellular stimulus	GO:0009991	116	0.013
non sensory hair organization	GO:0035316	47	0.013
protein import	GO:0017038	55	0.013
negative regulation of response to stimulus	GO:0048585	258	0.013
morphogenesis of a polarized epithelium	GO:0001738	93	0.013
regulation of transport	GO:0051049	181	0.013
nucleus organization	GO:0006997	45	0.013
limb development	GO:0060173	1	0.013
positive regulation of protein transport	GO:0051222	37	0.012
regulation of catalytic activity	GO:0050790	185	0.012
regulation of intracellular transport	GO:0032386	64	0.012
negative regulation of lamellocyte differentiation	GO:0035204	5	0.012
regulation of protein metabolic process	GO:0051246	256	0.012
hematopoietic or lymphoid organ development	GO:0048534	57	0.012
establishment of protein localization to plasma membrane	GO:0090002	9	0.012
regulation of response to stress	GO:0080134	200	0.012
regulation of chromosome segregation	GO:0051983	32	0.012
regulation of response to external stimulus	GO:0032101	115	0.012
morphogenesis of embryonic epithelium	GO:0016331	94	0.012
tissue death	GO:0016271	102	0.012
regulation of cellular localization	GO:0060341	136	0.012
regulation of photoreceptor cell differentiation	GO:0046532	34	0.012
compound eye photoreceptor development	GO:0042051	78	0.012
eye pigment biosynthetic process	GO:0006726	32	0.012
establishment of spindle localization	GO:0051293	22	0.012
protein localization	GO:0008104	284	0.012
extrinsic apoptotic signaling pathway	GO:0097191	1	0.012
cellular amine metabolic process	GO:0044106	12	0.011
hematopoietic progenitor cell differentiation	GO:0002244	1	0.011
axon target recognition	GO:0007412	16	0.011
negative regulation of cell death	GO:0060548	81	0.011
eye photoreceptor cell fate commitment	GO:0042706	37	0.011
regulation of response to dna damage stimulus	GO:2001020	23	0.011
synapse maturation	GO:0060074	7	0.011
nucleoside triphosphate catabolic process	GO:0009143	108	0.011
photoreceptor cell maintenance	GO:0045494	11	0.011
regulation of organ formation	GO:0003156	3	0.011
negative regulation of cell development	GO:0010721	62	0.011
actomyosin structure organization	GO:0031032	56	0.011
positive regulation of cellular amine metabolic process	GO:0033240	0	0.011
oxidation reduction process	GO:0055114	123	0.011
dna biosynthetic process	GO:0071897	24	0.011
peptidyl amino acid modification	GO:0018193	105	0.011
induction of programmed cell death by hormones	GO:0035081	12	0.011
cranial nerve development	GO:0021545	1	0.011
positive regulation of cellular component biogenesis	GO:0044089	80	0.011
establishment of localization in cell	GO:0051649	402	0.011
protein import into nucleus	GO:0006606	51	0.011
neural retina development	GO:0003407	4	0.011
spermatogenesis	GO:0007283	200	0.010
negative regulation of cell proliferation	GO:0008285	69	0.010
carbohydrate derivative metabolic process	GO:1901135	217	0.010
positive regulation of nucleotide catabolic process	GO:0030813	46	0.010
organic cyclic compound catabolic process	GO:1901361	168	0.010
photoreceptor cell development	GO:0042461	96	0.010
regulation of gliogenesis	GO:0014013	11	0.010
purine containing compound catabolic process	GO:0072523	112	0.010
regulation of r7 cell differentiation	GO:0045676	15	0.010

Nipped-A disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.032
nervous system disease	DOID:863	0.016
autosomal dominant nonsyndromic deafness	DOID:0050564	0.013
auditory system disease	DOID:2742	0.013
sensory system disease	DOID:0050155	0.013
nonsyndromic deafness	DOID:0050563	0.013

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network