IMP: Integrative Multi-species Prediction

Drosophila melanogaster

88 known processes

topi (Dmel_CG8484)

matotopetli

(Aliases: CG8484,Topi,Dmel\CG8484)

Entrez: 41199
FLYBASE: FBgn0037751
UniProtKB: T2FFH5
UniProtKB: Q9VH70

Process Predictions
Disease Predictions

topi biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
spermatid differentiation	GO:0048515	114	0.529
spermatogenesis	GO:0007283	200	0.188
male gamete generation	GO:0048232	201	0.172
small molecule metabolic process	GO:0044281	305	0.143
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.115
positive regulation of macromolecule metabolic process	GO:0010604	405	0.106
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.105
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.105
death	GO:0016265	284	0.105
nuclear division	GO:0000280	332	0.088
spermatid development	GO:0007286	98	0.086
positive regulation of biosynthetic process	GO:0009891	316	0.086
cell division	GO:0051301	248	0.082
positive regulation of cellular biosynthetic process	GO:0031328	316	0.077
positive regulation of rna metabolic process	GO:0051254	271	0.065
regulation of endopeptidase activity	GO:0052548	36	0.065
programmed cell death	GO:0012501	257	0.064
positive regulation of hydrolase activity	GO:0051345	78	0.061
positive regulation of rna biosynthetic process	GO:1902680	266	0.061
cell death	GO:0008219	279	0.061
organophosphate metabolic process	GO:0019637	195	0.058
carbohydrate derivative metabolic process	GO:1901135	217	0.054
transcription from rna polymerase ii promoter	GO:0006366	368	0.052
apoptotic process	GO:0006915	159	0.052
ion transmembrane transport	GO:0034220	122	0.051
positive regulation of gene expression	GO:0010628	290	0.051
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.051
meiotic nuclear division	GO:0007126	151	0.049
organonitrogen compound metabolic process	GO:1901564	318	0.046
cytokinesis	GO:0000910	90	0.046
nucleoside metabolic process	GO:0009116	127	0.045
sister chromatid segregation	GO:0000819	92	0.045
regulation of hydrolase activity	GO:0051336	97	0.045
chromosome organization	GO:0051276	360	0.044
cilium assembly	GO:0042384	38	0.044
regulation of proteolysis	GO:0030162	87	0.042
negative regulation of gene expression	GO:0010629	387	0.040
regulation of programmed cell death	GO:0043067	152	0.040
transmembrane transport	GO:0055085	139	0.038
single organism catabolic process	GO:0044712	228	0.038
positive regulation of endopeptidase activity	GO:0010950	26	0.038
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.038
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.038
organic substance catabolic process	GO:1901575	308	0.037
negative regulation of signal transduction	GO:0009968	206	0.037
organelle fusion	GO:0048284	46	0.037
positive regulation of transcription dna templated	GO:0045893	266	0.036
cation transmembrane transport	GO:0098655	88	0.036
carboxylic acid metabolic process	GO:0019752	92	0.035
regulation of cell cycle process	GO:0010564	181	0.035
negative regulation of cell communication	GO:0010648	223	0.035
sperm individualization	GO:0007291	48	0.034
single organism membrane fusion	GO:0044801	42	0.034
organelle fission	GO:0048285	340	0.034
negative regulation of cellular metabolic process	GO:0031324	382	0.034
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.034
positive regulation of cell communication	GO:0010647	250	0.034
regulation of catalytic activity	GO:0050790	185	0.033
positive regulation of molecular function	GO:0044093	136	0.033
regulation of cell death	GO:0010941	173	0.033
purine nucleoside metabolic process	GO:0042278	127	0.032
cellularization	GO:0007349	90	0.032
regulation of apoptotic process	GO:0042981	130	0.032
protein modification process	GO:0036211	438	0.032
positive regulation of catalytic activity	GO:0043085	118	0.031
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.031
cell proliferation	GO:0008283	299	0.031
cation transport	GO:0006812	110	0.031
appendage development	GO:0048736	401	0.031
proteolysis	GO:0006508	192	0.030
ribonucleoside metabolic process	GO:0009119	127	0.030
cellular protein modification process	GO:0006464	438	0.030
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.029
purine containing compound metabolic process	GO:0072521	155	0.029
organic acid metabolic process	GO:0006082	103	0.029
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.029
regulation of organelle organization	GO:0033043	196	0.029
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.028
regulation of anatomical structure morphogenesis	GO:0022603	242	0.028
cytoskeleton dependent cytokinesis	GO:0061640	81	0.028
activation of cysteine type endopeptidase activity	GO:0097202	17	0.028
positive regulation of signal transduction	GO:0009967	223	0.028
regulation of cell cycle phase transition	GO:1901987	130	0.028
oxoacid metabolic process	GO:0043436	103	0.028
regulation of intracellular signal transduction	GO:1902531	236	0.027
vesicle mediated transport	GO:0016192	381	0.027
organelle assembly	GO:0070925	198	0.027
regulation of cellular protein metabolic process	GO:0032268	243	0.027
spindle organization	GO:0007051	253	0.027
glycosyl compound metabolic process	GO:1901657	127	0.027
meiotic cell cycle	GO:0051321	171	0.027
phagocytosis	GO:0006909	215	0.027
positive regulation of proteolysis	GO:0045862	52	0.026
atp metabolic process	GO:0046034	49	0.026
purine ribonucleoside metabolic process	GO:0046128	127	0.025
nucleobase containing compound catabolic process	GO:0034655	165	0.025
single organism biosynthetic process	GO:0044711	206	0.025
regulation of localization	GO:0032879	275	0.025
nucleobase containing small molecule metabolic process	GO:0055086	174	0.025
protein maturation	GO:0051604	71	0.025
protein modification by small protein conjugation	GO:0032446	79	0.024
negative regulation of wnt signaling pathway	GO:0030178	28	0.024
negative regulation of mitotic cell cycle	GO:0045930	109	0.024
ribonucleotide metabolic process	GO:0009259	145	0.024
negative regulation of signaling	GO:0023057	219	0.024
protein localization	GO:0008104	284	0.024
cellular catabolic process	GO:0044248	372	0.024
protein processing	GO:0016485	68	0.024
regulation of molecular function	GO:0065009	217	0.023
regulation of protein metabolic process	GO:0051246	256	0.023
cellular response to dna damage stimulus	GO:0006974	223	0.023
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.023
organic substance transport	GO:0071702	257	0.023
regulation of catabolic process	GO:0009894	170	0.023
positive regulation of programmed cell death	GO:0043068	62	0.022
catabolic process	GO:0009056	409	0.022
body morphogenesis	GO:0010171	2	0.022
purine containing compound catabolic process	GO:0072523	112	0.022
regulation of response to stress	GO:0080134	200	0.021
nucleoside phosphate metabolic process	GO:0006753	162	0.021
purine nucleotide metabolic process	GO:0006163	146	0.021
developmental programmed cell death	GO:0010623	138	0.021
proteasomal protein catabolic process	GO:0010498	59	0.021
regulation of cellular catabolic process	GO:0031329	157	0.020
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.020
somatic muscle development	GO:0007525	66	0.020
positive regulation of cellular catabolic process	GO:0031331	95	0.020
eye development	GO:0001654	323	0.020
amine metabolic process	GO:0009308	12	0.020
multi multicellular organism process	GO:0044706	123	0.019
inorganic cation transmembrane transport	GO:0098662	61	0.019
cellular amine metabolic process	GO:0044106	12	0.019
purine ribonucleotide metabolic process	GO:0009150	145	0.019
heterocycle catabolic process	GO:0046700	166	0.019
negative regulation of cellular component organization	GO:0051129	108	0.019
ubiquitin dependent protein catabolic process	GO:0006511	78	0.019
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.019
nucleoside triphosphate metabolic process	GO:0009141	120	0.019
posttranscriptional regulation of gene expression	GO:0010608	145	0.019
cell cycle checkpoint	GO:0000075	95	0.019
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.019
regulation of cell cycle	GO:0051726	291	0.019
ribose phosphate metabolic process	GO:0019693	145	0.018
negative regulation of rna metabolic process	GO:0051253	251	0.018
nucleotide metabolic process	GO:0009117	161	0.018
compound eye development	GO:0048749	307	0.018
carbohydrate derivative catabolic process	GO:1901136	118	0.018
intracellular signal transduction	GO:0035556	300	0.018
regulation of cellular amine metabolic process	GO:0033238	3	0.018
modification dependent protein catabolic process	GO:0019941	78	0.018
cellular macromolecule catabolic process	GO:0044265	136	0.018
cellular protein localization	GO:0034613	160	0.018
aromatic compound catabolic process	GO:0019439	166	0.018
macromolecule catabolic process	GO:0009057	161	0.018
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.018
protein modification by small protein conjugation or removal	GO:0070647	106	0.018
meiosis ii	GO:0007135	23	0.017
purine nucleoside catabolic process	GO:0006152	112	0.017
regulation of cellular amino acid metabolic process	GO:0006521	0	0.017
response to organic substance	GO:0010033	284	0.017
organic cyclic compound catabolic process	GO:1901361	168	0.017
membrane organization	GO:0061024	112	0.017
glycosyl compound catabolic process	GO:1901658	112	0.017
organic acid transport	GO:0015849	18	0.017
modification dependent macromolecule catabolic process	GO:0043632	79	0.017
microtubule organizing center organization	GO:0031023	168	0.017
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.016
mitotic cell cycle checkpoint	GO:0007093	88	0.016
positive regulation of response to stimulus	GO:0048584	323	0.016
negative regulation of cellular catabolic process	GO:0031330	34	0.016
negative regulation of cellular biosynthetic process	GO:0031327	277	0.016
regulation of protein catabolic process	GO:0042176	55	0.016
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.016
response to external biotic stimulus	GO:0043207	293	0.016
regulation of cell division	GO:0051302	72	0.016
segment polarity determination	GO:0007367	25	0.016
positive regulation of intracellular signal transduction	GO:1902533	116	0.016
intracellular transport	GO:0046907	228	0.016
eye morphogenesis	GO:0048592	260	0.016
response to biotic stimulus	GO:0009607	294	0.016
histolysis	GO:0007559	102	0.016
homeostatic process	GO:0042592	199	0.016
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.016
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.016
regulation of mitosis	GO:0007088	56	0.016
positive regulation of signaling	GO:0023056	243	0.016
ribonucleoside catabolic process	GO:0042454	112	0.016
meiotic cell cycle process	GO:1903046	132	0.016
regulation of cellular response to stress	GO:0080135	89	0.015
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	16	0.015
chromosome separation	GO:0051304	42	0.015
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.015
male meiosis	GO:0007140	52	0.015
carbohydrate metabolic process	GO:0005975	82	0.015
ion transport	GO:0006811	145	0.015
growth	GO:0040007	359	0.015
response to abiotic stimulus	GO:0009628	341	0.015
negative regulation of biosynthetic process	GO:0009890	277	0.015
regionalization	GO:0003002	416	0.015
salivary gland cell autophagic cell death	GO:0035071	83	0.015
blastoderm segmentation	GO:0007350	159	0.015
mitotic sister chromatid segregation	GO:0000070	87	0.015
regulation of transport	GO:0051049	181	0.015
embryonic pattern specification	GO:0009880	174	0.015
single organism intracellular transport	GO:1902582	207	0.015
cellular component assembly involved in morphogenesis	GO:0010927	151	0.015
gland development	GO:0048732	191	0.015
ethanolamine containing compound metabolic process	GO:0042439	4	0.015
negative regulation of protein metabolic process	GO:0051248	85	0.015
camera type eye development	GO:0043010	4	0.014
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.014
response to bacterium	GO:0009617	198	0.014
protein ubiquitination	GO:0016567	70	0.014
compound eye morphogenesis	GO:0001745	249	0.014
regulation of phosphate metabolic process	GO:0019220	210	0.014
nucleoside monophosphate metabolic process	GO:0009123	52	0.014
response to lipopolysaccharide	GO:0032496	4	0.014
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.014
mitotic cell cycle phase transition	GO:0044772	138	0.014
positive regulation of peptidase activity	GO:0010952	29	0.014
response to alcohol	GO:0097305	95	0.014
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.014
nucleoside phosphate catabolic process	GO:1901292	110	0.014
regulation of peptidase activity	GO:0052547	39	0.014
nucleoside catabolic process	GO:0009164	112	0.014
monocarboxylic acid transport	GO:0015718	3	0.014
imaginal disc derived wing morphogenesis	GO:0007476	337	0.014
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.014
embryo development ending in birth or egg hatching	GO:0009792	152	0.014
regulation of multicellular organismal development	GO:2000026	414	0.014
spindle assembly	GO:0051225	80	0.014
l amino acid import	GO:0043092	2	0.014
wing disc morphogenesis	GO:0007472	344	0.014
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.014
defense response to bacterium	GO:0042742	178	0.014
antimicrobial humoral response	GO:0019730	99	0.014
cellular nitrogen compound catabolic process	GO:0044270	165	0.014
cellular protein catabolic process	GO:0044257	83	0.014
regulation of cell differentiation	GO:0045595	302	0.013
protein catabolic process	GO:0030163	101	0.013
negative regulation of rna biosynthetic process	GO:1902679	240	0.013
chromatin remodeling	GO:0006338	72	0.013
nucleoside triphosphate catabolic process	GO:0009143	108	0.013
regulation of phosphorus metabolic process	GO:0051174	210	0.013
regulation of microtubule based process	GO:0032886	49	0.013
synapse organization	GO:0050808	196	0.013
imaginal disc derived appendage development	GO:0048737	399	0.013
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.013
negative regulation of organelle organization	GO:0010639	56	0.013
cell cycle phase transition	GO:0044770	140	0.013
purine ribonucleoside catabolic process	GO:0046130	112	0.013
regulation of cellular ketone metabolic process	GO:0010565	3	0.013
cytoplasmic transport	GO:0016482	130	0.013
endocytosis	GO:0006897	310	0.013
nucleotide catabolic process	GO:0009166	109	0.013
positive regulation of cell death	GO:0010942	69	0.013
purine ribonucleotide catabolic process	GO:0009154	109	0.013
regulation of epithelial cell differentiation	GO:0030856	4	0.012
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.012
negative regulation of cell cycle process	GO:0010948	109	0.012
positive regulation of cellular protein metabolic process	GO:0032270	118	0.012
establishment of localization in cell	GO:0051649	402	0.012
cellular amino acid metabolic process	GO:0006520	61	0.012
negative regulation of cell cycle phase transition	GO:1901988	103	0.012
maintenance of location	GO:0051235	73	0.012
embryonic development via the syncytial blastoderm	GO:0001700	148	0.012
gland morphogenesis	GO:0022612	145	0.012
single organism membrane organization	GO:0044802	93	0.012
positive regulation of protein metabolic process	GO:0051247	128	0.012
exocrine system development	GO:0035272	162	0.012
positive regulation of phosphate metabolic process	GO:0045937	139	0.012
mitotic spindle organization	GO:0007052	220	0.012
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.012
regulation of cell projection organization	GO:0031344	92	0.011
metal ion transport	GO:0030001	74	0.011
positive regulation of transport	GO:0051050	92	0.011
cellular lipid metabolic process	GO:0044255	83	0.011
purine nucleotide catabolic process	GO:0006195	109	0.011
positive regulation of phosphorus metabolic process	GO:0010562	139	0.011
cellular homeostasis	GO:0019725	80	0.011
regulation of synapse organization	GO:0050807	110	0.011
organonitrogen compound biosynthetic process	GO:1901566	117	0.011
positive regulation of nucleoside metabolic process	GO:0045979	47	0.011
forebrain development	GO:0030900	2	0.011
response to other organism	GO:0051707	293	0.011
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.011
negative regulation of proteolysis	GO:0045861	31	0.011
inorganic ion transmembrane transport	GO:0098660	73	0.011
salivary gland development	GO:0007431	162	0.011
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.011
positive regulation of apoptotic process	GO:0043065	47	0.011
response to nutrient levels	GO:0031667	114	0.011
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.011
cell migration	GO:0016477	238	0.011
salivary gland morphogenesis	GO:0007435	145	0.011
regulation of cell development	GO:0060284	215	0.011
organonitrogen compound catabolic process	GO:1901565	128	0.011
segmentation	GO:0035282	207	0.011
appendage morphogenesis	GO:0035107	397	0.011
axonogenesis	GO:0007409	290	0.011
response to oxygen containing compound	GO:1901700	200	0.011
larval development	GO:0002164	104	0.010
positive regulation of cell motility	GO:2000147	3	0.010
telencephalon development	GO:0021537	2	0.010
positive regulation of catabolic process	GO:0009896	105	0.010
phosphorylation	GO:0016310	294	0.010
immune response	GO:0006955	246	0.010
post embryonic appendage morphogenesis	GO:0035120	385	0.010
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.010
intrinsic apoptotic signaling pathway	GO:0097193	16	0.010
nitrogen compound transport	GO:0071705	85	0.010
single organism carbohydrate metabolic process	GO:0044723	72	0.010
kidney development	GO:0001822	3	0.010
negative regulation of apoptotic process	GO:0043066	63	0.010

topi disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.026
nervous system disease	DOID:863	0.019
sensory system disease	DOID:0050155	0.012
eye and adnexa disease	DOID:1492	0.010

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